FASTING AND CARDIO-PROTECTION
HORMESIS
What’s that? To understand dry fasting (deliberate dehydration and starvation) is to understand hormesis.
“That which doesn’t kill you makes you stronger.” — Nietzsche
“All things are poison and nothing is without poison; only the dose makes a thing not a poison.” —Paracelsus
Even water and oxygen in excess can be deadly; as can their absence.
What we are doing is deliberately stressing the body— to make it more resilient.
“Hormesis is a biological phenomenon whereby a beneficial effect (improved health, stress tolerance, growth or longevity) results from exposure to low doses of an agent that is otherwise toxic or lethal when given at higher doses.”
Too much dry fasting can kill just as over eating or over drinking can kill.
We are in a sense flexing our cells “muscles”; making them extremely adaptable and tough.
“No water? No food? No problem. Wake me up when we got a real crisis on our hands.”
All about hormesis HERE
***INSULIN BLOCKS SIRT1***
SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (S. cerevisiae) is Sir2. SIRT1 is an enzyme that deacetylates proteins that contribute to cellular regulation (reaction to stressors, longevity).
A major cause of aging is thought to result from the cumulative effects of cell loss over time. In yeast, caloric restriction (CR) delays aging by activating the Sir2 deacetylase. Here we show that expression of mammalian Sir2 (SIRT1) is induced in CR rats as well as in human cells that are treated with serum from these animals. Insulin and insulin-like growth factor 1 (IGF-1) attenuated this response. SIRT1 deacetylates the DNA repair factor Ku70, causing it to sequester the proapoptotic factor Bax away from mitochondria, thereby inhibiting stress-induced apoptotic cell death. Thus, CR could extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells.
SOURCE: HERE
(CONTINUED IN THE NEXT BLOG TITLED “FASTING AND STEM CELL REGENERATION”)