SENESCENT CELLS, SASP & SENOLYTICS

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SHIPPING APRIL 15TH!!!

Interstellar Blend Senolytic Zombie Senescent Cell Killer

ZOMBIE CELL KILLER

 

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SCIENTIFIC STUDIES:

  1. The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
  2. The Clinical Potential of senolytic Drugs
  3. Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
  4. Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
  5. Clinical strategies and animal models for developing senolytic agents
  6. senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo
  7. Discovery of piperlongumine as a potential novel lead for the development of senolytic agents
  8. Pleiotropic Effects of Tocotrienols and Quercetin on Cellular senescence: Introducing the Perspective of senolytic Effects of Phytochemicals
  9. A Novel Indication for Panobinostat as a senolytic Drug in NSCLC and HNSCC
  10. Oxidation resistance 1 is a novel senolytic target
  11. Effects of senolytic drugs on human mesenchymal stromal cells
  12. senolytic activity of piperlongumine analogues: Synthesis and biological evaluation
  13. Hsp90 inhibitors as senolytic drugs to extend healthy aging
  14. The curcumin analog EF24 is a novel senolytic agent
  15. senolytic drugs in respiratory medicine: is it an appropriate therapeutic approach?
  16. senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model
  17. Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts
  18. Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin
  19. senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of senescence-Inducing Chemotherapy in Liver Cancer
  20. Emerging senolytic agents derived from natural products
  21. senolytic treatments applied to osteoarthritis: a step towards the end of orthopedic surgery?
  22. Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy
  23. Curcumin and o-Vanillin Exhibit Evidence of senolytic Activity in Human IVD Cells In Vitro
  24. senolytic helpers
  25. senolytic therapies for healthy longevity
  26. Removing Aging Cells With a New Class of senolytic Drug
  27. Quercetin in Idiopathic Pulmonary Fibrosis: Another Brick in the senolytic Wall
  28. SAT0053 Identification of novel drugs with senolytic activity as osteoarthritis therapeutics
  29. Abstract 11299: A Novel senolytic Drug for Aging and Age-Related Cardiometabolic Disorders
  30. Novel Classification Perspective of Geroprotective and senolytic Drugs as an Antiaging Strategy
  31. LSC – 2017 – senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo
  32. senolytic treatment targets aberrant p21-expression to restore liver regeneration in adult mice
  33. Augmented Inflammatory Responses in Aging are Driven by Circulating mtDNA and Ameliorated by senolytic Treatment
  34. senescence Signature in Skin Biopsies From Systemic Sclerosis Patients Treated With senolytic Therapy: Potential Predictor of Clinical Response?
  35. Fenofibrate, a peroxisome proliferator-activated receptor alpha, is a novel molecule with senolytic and autophagy activity for cartilage degeneration and osteoarthritis
  36. senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and cartilage regeneration in osteoarthritis
  37. Treatment of parkinson’s disease and other conditions caused or mediated by senescent astrocytes using small molecule senolytic agents
  38. Application of ex-vivo spheroid model system for the analysis of senescence and senolytic phenotypes in uterine leiomyoma
  39. AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts
  40. Mitochondrial DNA-Mediated Inflammatory Injury in Old Donors Is Improved by senolytic Treatment
  41. The biology of senescence.
  42. Leaf senescence
  43. Cellular senescence in Aging Primates
  44. senescence in premalignant tumours
  45. senescence mechanisms
  46. Cancer, aging and cellular senescence.
  47. The essence of senescence
  48. Four faces of cellular senescence
  49. Microarray analysis of replicative senescence
  50. Aging, Cellular senescence, and Cancer
  51. Molecular aspects of leaf senescence
  52. Cellular senescence in Cancer and Aging
  53. Making Sense of senescence (Molecular Genetic Regulation and Manipulation of Leaf senescence).
  54. Pleiotropy, Natural Selection, and the Evolution of senescence
  55. Cellular senescence as a tumor-suppressor mechanism
  56. Ageing. The biology of senescence.
  57. CHLOROPHYLL DEGRADATION DURING senescence*
  58. The moulding of senescence by natural selection
  59. The molecular biology of leaf senescence
  60. Gene expression during leaf senescence
  61. A new murine model of accelerated senescence
  62. The biology of replicative senescence
  63. The senescence of leaves.
  64. A DNA damage checkpoint response in telomere-initiated senescence
  65. Cellular senescence: from physiology to pathology
  66. Putting the stress on senescence
  67. Rapamycin decelerates cellular senescence
  68. Inhibition of Leaf senescence by Autoregulated Production of Cytokinin
  69. senescence and Postharvest Physiology
  70. Free radicals and senescence
  71. Cellular senescence: when bad things happen to good cells
  72. Bmi1, stem cells, and senescence regulation
  73. The signals and pathways activating cellular senescence
  74. senescence-accelerated mouse (SAM): A novel murine model of senescence
  75. Testosterone Secretion and Metabolism in Male senescence
  76. senescence in Plant Development
  77. Catalase, Peroxidase, and Polyphenoloxidase Activities during Rice Leaf senescence
  78. Replicative senescence: An Old Lives’ Tale?
  79. Transcriptome of Arabidopsis leaf senescence
  80. Nitrogen metabolism and remobilization during senescence
  81. Tumor Cell senescence in Cancer Treatment
  82. senescence Induced by Altered Telomere State, Not Telomere Loss
  83. senescence of Activated Stellate Cells Limits Liver Fibrosis
  84. Telomeres, telomerase and senescence
  85. LABORATORY EVOLUTION OF POSTPONED senescence IN DROSOPHILA MELANOGASTER
  86. Defining senescence and death
  87. Chemokine Signaling via the CXCR2 Receptor Reinforces senescence
  88. FUNGAL senescence
  89. Telomeres, stem cells, senescence, and cancer
  90. Replicative senescence: the human fibroblast comes of age
  91. Evolution of senescence: late survival sacrificed for reproduction
  92. Cellular senescence
  93. SELECTION FOR DELAYED senescence IN DROSOPHILA MELANOGASTER
  94. senescence in tumours: evidence from mice and humans
  95. Fat tissue, aging, and cellular senescence
  96. Inflammatory networks during cellular senescence: causes and consequences
  97. senescence
  98. Role of Ceramide in Cellular senescence
  99. senescence of human fibroblasts induced by oncogenic Raf
  100. Ethylene and flower senescence
  101. Cell senescence and cancer
  102. Therapy-Induced senescence in Cancer
  103. Genes involved in senescence and immortalization
  104. BRAFE600-associated senescence-like cell cycle arrest of human naevi
  105. Vascular Cell senescence
  106. Reversible inhibition of tomato fruit senescence by antisense RNA
  107. A senescent cell bystander effect: senescence‐induced senescence
  108. Molecular regulation of leaf senescence
  109. senescence in a Bacterium with Asymmetric Division
  110. senescence-messaging secretome: SMS-ing cellular stress
  111. Leaf senescence
  112. senescence, Apoptosis or Autophagy?
  113. senescence and immortalization: role of telomeres and telomerase
  114. senescence‐Accelerated Mouse (SAM): A Novel Murine Model of Accelerated senescence
  115. Regulation of cellular senescence by p53
  116. If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells
  117. senescence.7.aspx”>Oxidation and erythrocyte senescence
  118. Formation of MacroH2A-Containing senescence-Associated Heterochromatin Foci and senescence Driven by ASF1a and HIRA
  119. Oncogene-induced senescence as an initial barrier in lymphoma development
  120. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
  121. Tumor suppressors and oncogenes in cellular senescence
  122. senescence in human intervertebral discs
  123. Oncogene-Induced senescence Relayed by an Interleukin-Dependent Inflammatory Network
  124. Cellular senescence and its effector programs
  125. 15 – Whole Plant senescence
  126. Cellular senescence and organismal aging
  127. senescence-Associated Gene Expression during Ozone-Induced Leaf senescence in Arabidopsis
  128. Human senescence
  129. senescence impairs successful reprogramming to pluripotent stem cells
  130. Oncogenic ras Provokes Premature Cell senescence Associated with Accumulation of p53 and p16INK4a
  131. Programmed Cell senescence during Mammalian Embryonic Development
  132. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
  133. The case for negative senescence
  134. Methods to Detect Biomarkers of Cellular senescence
  135. senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
  136. senescence‐associated β‐galactosidase is lysosomal β‐galactosidase
  137. Akt Determines Replicative senescence and Oxidative or Oncogenic Premature senescence and Sensitizes Cells to Oxidative Apoptosis
  138. Deferral of Leaf senescence with Calcium
  139. Experimental Modification of Plant senescence.
  140. The Activated Oxygen Role of Peroxisomes in senescence
  141. Aging, articular cartilage chondrocyte senescence and osteoarthritis
  142. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
  143. Pro-senescence therapy for cancer treatment
  144. senescence comes of age
  145. The senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
  146. Oxidative DNA damage and senescence of human diploid fibroblast cells
  147. senescence surveillance of pre-malignant hepatocytes limits liver cancer development
  148. Extreme heat effects on wheat senescence in India
  149. Cellular senescence: putting the paradoxes in perspective
  150. Cellular senescence and cancer treatment
  151. Calcium in plant senescence and fruit ripening
  152. An alternative pathway for yeast telomere maintenance rescues est1− senescence
  153. THE TWO-STAGE MECHANISM CONTROLLING CELLULAR senescence AND IMMORTALIZATION
  154. Ethylene, Plant senescence and Abscission
  155. The molecular genetic analysis of leaf senescence
  156. Hallmarks of senescence in carcinogenesis and cancer therapy
  157. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
  158. Homocysteine accelerates endothelial cell senescence
  159. The molecular analysis of leaf senescence – a genomics approach
  160. A Cellular Timetable of Autumn senescence
  161. MicroRNA-34a regulation of endothelial senescence
  162. Involvement of Hydrogen Peroxide in the Regulation of senescence in Pear
  163. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
  164. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
  165. Deconstructing PML-induced premature senescence
  166. Mortality Patterns Suggest Lack of senescence in Hydra
  167. Plant senescence processes and free radicals
  168. Role of oxidative carbonylation in protein quality control and senescence
  169. Measuring Wheat senescence with a Digital Camera
  170. Brain acetylcholine synthesis declines with senescence
  171. Human cell senescence as a DNA damage response
  172. Molecular genetics of leaf senescence in Arabidopsis
  173. Development and senescence of the Postnatal Bovine Ovary
  174. Leaf senescence in Brassica napus: cloning of senescence related genes by subtractive hybridisation
  175. Alveolar Cell senescence in Patients with Pulmonary Emphysema
  176. Functional senescence in Drosophila melanogaster
  177. Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity
  178. The evolutionary ecology of senescence
  179. Replicative senescence: Implications for in Vivo Aging and Tumor Suppression
  180. SASP reflects senescence
  181. Ethylene regulates the timing of leaf senescence in Arabidopsis
  182. Cellular senescence, cancer and aging: the telomere connection
  183. Control of Jasmonate Biosynthesis and senescence by miR319 Targets
  184. Replicative senescence of Mesenchymal Stem Cells: A Continuous and Organized Process
  185. T-helper-1-cell cytokines drive cancer into senescence
  186. Cellular senescence and tumor suppressor gene p16
  187. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
  188. Telomeres and senescence: Ending the Debate
  189. Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular senescence
  190. The aging brain: morphomolecular senescence of cortical circuits
  191. Reversal of human cellular senescence: roles of the p53 and p16 pathways
  192. Molecular analysis of natural leaf senescence in Arabidopsis thaliana
  193. A transcriptional timetable of autumn senescence
  194. Cellular senescence and cancer
  195. Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence
  196. Telomere dysfunction and tumour suppression: the senescence connection
  197. Many roads lead to oncogene-induced senescence
  198. A negative feedback signaling network underlies oncogene-induced senescence
  199. The anemia of senescence
  200. Plant senescence and crop productivity
  201. Replicative senescence: a critical review
  202. senescence in Health and Disease
  203. A NAC Gene Regulating senescence Improves Grain Protein, Zinc, and Iron Content in Wheat
  204. Last exit: senescence, abscission, and meristem arrest in Arabidopsis.
  205. Memory loss in senescence.
  206. Cigarette Smoke Induces Cellular senescence
  207. Rethinking Chronic Allograft Nephropathy
    The Concept of Accelerated senescence
  208. The sound of senescence
  209. Oncogenic Braf Induces Melanocyte senescence and Melanoma in Mice
  210. What has senescence got to do with cancer?
  211. Targets of AtWRKY6 regulation during plant senescence and pathogen defense
  212. Telomerase, senescence and ageing
  213. Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.
  214. PML is induced by oncogenic ras and promotes premature senescence
  215. The senescence-Induced Staygreen Protein Regulates Chlorophyll Degradation
  216. Bypass of senescence After Disruption of p21CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts
  217. Differential expression of senescence-associated mRNAs during leaf senescence induced by different senescence-inducing factors in Arabidopsis
  218. Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts.
  219. An attempt to prevent senescence: A mitochondrial approach
  220. Delayed leaf senescence induces extreme drought tolerance in a flowering plant
  221. senescence and Rejuvenation
  222. Forging a signature of in vivo senescence
  223. Evolutionary and Nonevolutionary Theories of senescence
  224. Cellular senescence revisited: a review
  225. Living on a break: cellular senescence as a DNA-damage response
  226. senescence in the whole plant.
  227. Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for senescence?
  228. Geriatric muscle stem cells switch reversible quiescence into senescence
  229. Physiology and molecular biology of petal senescence
  230. Endothelial Cell senescence in Human Atherosclerosis
  231. Telomere positional effects and the regulation of cellular senescence
  232. Role of Ethylene in senescence of Petals—Morphological and Taxonomical Relationships
  233. Paradoxical suppression of cellular senescence by p53
  234. Evidence Supporting a Role of Jasmonic Acid in Arabidopsis Leaf senescence
  235. Prohibitin: Potential role in senescence, development, and tumor suppression
  236. senescence and aging: the critical roles of p53
  237. senescence as a mode of tumor suppression.
  238. Large‐scale identification of leaf senescence‐associated genes
  239. NK and NK/T cells in human senescence
  240. Vascular endothelial senescence: from mechanisms to pathophysiology
  241. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence.
  242. When cells get stressed: an integrative view of cellular senescence
  243. A mutant with a defect in telomere elongation leads to senescence in yeast
  244. Selenium – an antioxidative protectant in soybean during senescence
  245. Oncogene-Induced senescence: Putting the Brakes on Tumor Development
  246. The power and the promise of oncogene-induced senescence markers
  247. The role of chondrocyte senescence in osteoarthritis
  248. OSTEOPOROSIS : DISEASE OR senescence ?
  249. The pathobiology of Parkinson’s disease: biochemical aspects of dopamine neuron senescence.
  250. A complex secretory program orchestrated by the inflammasome controls paracrine senescence
  251. Growth, Maturation, and senescence in Fruits
  252. ORE9, an F-Box Protein That Regulates Leaf senescence in Arabidopsis
  253. Cell senescence and hypermitogenic arrest
  254. Cellular senescence mediates fibrotic pulmonary disease
  255. Accelerated immune senescence and HIV-1 infection
  256. senescence of leafy vegetables
  257. Mitotic and postmitotic senescence in plants.
  258. NaCl-induced senescence in Leaves of Rice (Oryza sativaL.) Cultivars Differing in Salinity Resistance
  259. Erosion of the telomeric single-strand overhang at replicative senescence
  260. Mechanisms of cellular senescence in human and mouse cells
  261. Loss of ‘Complexity’ and AgingPotential Applications of Fractals and Chaos Theory to senescence
  262. Id proteins in cell cycle control and cellular senescence
  263. A role for both RB and p53 in the regulation of human cellular senescence
  264. Physiological significance of anthocyanins during autumnal leaf senescence
  265. Lamin B1 loss is a senescence-associated biomarker
  266. Isolation and Identification of a senescence-promoting Substance from Wormwood (Artemisia absinthium L.)
  267. Oxidative stress and antioxidant activity as the basis of senescence in maize leaves
  268. Nutrients mobilized from leaves of Arabidopsis thaliana during leaf senescence
  269. Ethylene in Plant Growth, Development, and senescence
  270. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
  271. Ras Proteins Induce senescence by Altering the Intracellular Levels of Reactive Oxygen Species
  272. Flower senescence in daylily (Hemerocallis)
  273. Role of Oxidative Stress in Telomere Length Regulation and Replicative senescence
  274. Leaf senescence: Correlated with Increased Levels of Membrane Permeability and Lipid Peroxidation, and Decreased Levels of Superoxide Dismutase and Catalase
  275. Deletion of Ku86 causes early onset of senescence in mice
  276. senescence, apoptosis and therapy — cutting the lifelines of cancer
  277. Cellular senescence: A Translational Perspective
  278. senescence-accelerated mouse (SAM): a biogerontological resource in aging research
  279. The timing of maize leaf senescence and characterisation of senescence‐related cDNAs
  280. Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
  281. Human melanocyte senescence and melanoma susceptibility genes
  282. UV-C treatment delays postharvest senescence in broccoli florets
  283. Processes and control of plant senescence.
  284. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
  285. Pollination-induced flower senescence: a review
  286. Structure elucidation of a senescence cross-link from human extracellular matrix. Implication of pentoses in the aging process.
  287. Oncogene-Induced Cell senescence — Halting on the Road to Cancer
  288. Mitochondrial Dysfunction Contributes to Oncogene-Induced senescence
  289. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
  290. Cell cycle arrest is not senescence
  291. Proteolytic activity during senescence of plants
  292. senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
  293. senescence IN NATURAL POPULATIONS OF MAMMALS: A COMPARATIVE STUDY
  294. Grading score system: A method for evaluation of the degree of senescence in senescence Accelerated Mouse (SAM)
  295. Oncogenic ras and p53 Cooperate To Induce Cellular senescence
  296. senescence, Abscission and Cellulase Activity in Phaseolus vulgaris
  297. Oncogenic BRAF Induces senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7
  298. Early Immune senescence in HIV Disease
  299. The role of senescence and immortalization in carcinogenesis
  300. Leaf senescence: Signals, Execution, and Regulation
  301. Cellular senescence and chromatin structure
  302. Cellular senescence in vivo: a barrier to tumorigenesis
  303. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells,
  304. The shaping of senescence in the wild
  305. Molecular Dissection of Formation of senescence-Associated Heterochromatin Foci
  306. Short Telomeres Limit Tumor Progression In Vivo by Inducing senescence
  307. Zeb1 links epithelial-mesenchymal transition and cellular senescence
  308. Cellular senescence controls fibrosis in wound healing
  309. Jasmonates: Hormonal regulators or stress factors in leaf senescence?
  310. Effect of extrinsic mortality on the evolution of senescence in guppies
  311. Replicative senescence and Oxidant‐Induced Premature senescence: Beyond the Control of Cell Cycle Checkpoints
  312. Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent senescence
  313. Immunologic Deficiencies in senescence
  314. Telomeres and senescence: The history, the experiment, the future
  315. A senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy
  316. senescence As an Anticancer Mechanism
  317. Changes in antioxidative enzymes in cucumber cotyledons during natural senescence: comparison with those during dark‐induced senescence
  318. senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells
  319. MicroRNA 217 Modulates Endothelial Cell senescence via Silent Information Regulator 1
  320. The Role of Cellular senescence in Skin Aging
  321. Identification of three genetic loci controlling leaf senescence in Arabidopsis thaliana
  322. Pathobiology of the senescence-accelerated mouse (SAM)
  323. Biochemistry of senescence
  324. Optimization of edible coating composition to retard strawberry fruit senescence
  325. Population cycles in microtines: The senescence hypothesis
  326. Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?
  327. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
  328. Mitochondria: are they the seat of senescence?
  329. senescence of red blood cells: progress and problems
  330. Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis.
  331. T cell senescence.
  332. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
  333. Escape from senescence in human diploid fibroblasts induced directly by mutant p53.
  334. senescence, ageing and death of the whole plant
  335. Reactive Oxygen Species as Mediators of Cellular senescence
  336. TAp63 induces senescence and suppresses tumorigenesis in vivo
  337. p53, ROS and senescence in the control of aging
  338. Cellular senescence in aging and age-related disease: from mechanisms to therapy
  339. Cellular senescence: hot or what?
  340. Microglial senescence: does the brain’s immune system have an expiration date?
  341. A genetic analysis of senescence in Drosophila
  342. Non‐destructive optical detection of pigment changes during leaf senescence and fruit ripening
  343. Role of CMV in immune senescence
  344. JunD Protects Cells from p53-Dependent senescence and Apoptosis
  345. MORPHOLOGIC CHANGES ACCOMPANYING senescence OF CULTURED HUMAN DIPLOID CELLS
  346. Quantitative assessment of markers for cell senescence
  347. Caspase inhibition switches doxorubicin-induced apoptosis to senescence
  348. Replicative senescence of human fibroblast-like cells in culture
  349. Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis
  350. A senescence-associated gene of Arabidopsis thaliana is distinctively regulated during natural and artificially induced leaf senescence
  351. Impact of cellular senescence signature on ageing research
  352. DNA damage response and cellular senescence in tissues of aging mice
  353. Lack of Replicative senescence in Normal Rodent Glia
  354. Peroxisome senescence in Human Fibroblasts
  355. Effects of estrogen on growth plate senescence and epiphyseal fusion
  356. DNA damage, cellular senescence and organismal ageing: causal or correlative?
  357. Lack of Replicative senescence in Cultured Rat Oligodendrocyte Precursor Cells
  358. Human Platelet senescence
  359. Feedback between p21 and reactive oxygen production is necessary for cell senescence
  360. Oncogene-Induced senescence Pathways Weave an Intricate Tapestry
  361. A Role for Diacylglycerol Acyltransferase during Leaf senescence
  362. senescence-induced RNases in tomato
  363. Identification of a transcription factor specifically expressed at the onset of leaf senescence
  364. PRAK Is Essential for ras-Induced senescence and Tumor Suppression
  365. Relation between leaf senescence and stomatal closure: senescence in light
  366. Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I—effects of proliferative senescence
  367. Total body irradiation selectively induces murine hematopoietic stem cell senescence
  368. Is Petal senescence Due to Sugar Starvation?
  369. senescence and apoptosis: dueling or complementary cell fates?
  370. Cellular senescence as a tumor-protection mechanism: the essential role of counting
  371. AtNAP, a NAC family transcription factor, has an important role in leaf senescence
  372. Metabolism of Oat Leaves during senescence
    V. senescence in Light
  373. Leaf senescence in rice plants: cloning and characterization of senescence up‐regulated genes
  374. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
  375. Memory T cell homeostasis and senescence during aging
  376. Natal dispersal and senescence
  377. Cell wall metabolism during maturation, ripening and senescence of peach fruit
  378. senescence, sleep, and circadian rhythms
  379. Neurologic Signs in senescence
  380. Genetic regulation of embryo death and senescence
  381. Lysosome-mediated processing of chromatin in senescence
  382. The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
  383. senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
  384. Inside and out: the activities of senescence in cancer
  385. p16Ink4a in Melanocyte senescence and Differentiation
  386. Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis
  387. Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas
  388. Autophagy facilitates oncogene-induced senescence
  389. Cellular senescence: A link between cancer and age-related degenerative disease?
  390. senescence‐associated intrinsic mechanisms of osteoblast dysfunctions
  391. Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
  392. Secretion of Vascular Endothelial Growth Factor by Primary Human Fibroblasts at senescence
  393. Transcription factors regulating leaf senescence in Arabidopsis thaliana
  394. Expression of senescence‐enhanced genes in response to oxidative stress
  395. A Phylogenetic Evaluation of Whether Endophytes Become Saprotrophs at Host senescence
  396. Mitochondria, telomeres and cell senescence
  397. Mechanisms, Functional Consequences, and Potential Therapeutics for Cellular senescence
  398. Evidence for programmed cell death during leaf senescence in plants [1998]
  399. senescence: a new weapon for cancer therapy
  400. Ethylene Production During senescence of Flowers
  401. Die and let live: leaf senescence contributes to plant survival under drought stress
  402. Astrocyte senescence as a Component of Alzheimer’s Disease
  403. Alcohols and Carnation senescence
  404. AGE‐SPECIFIC SURVIVAL IN FIVE POPULATIONS OF UNGULATES: EVIDENCE OF senescence
  405. Fibroblast senescence in pressure ulcers
  406. Mental efficiency in senescence.
  407. Chloroplasts regulate leaf senescence: delayed senescence in transgenic ndhF-defective tobacco
  408. Retarded senescence in an insular population of Virginia opossums (Didelphis virginiana)
  409. Ink4a/Arf links senescence and aging
  410. Retardation of radish leaf senescence by polyamines
  411. Salicylic acid has a role in regulating gene expression during leaf senescence
  412. DNA Damage Is Able to Induce senescence in Tumor Cells in Vitro and in Vivo
  413. Hormone receptor changes during adulthood and senescence: significance for aging research.
  414. Vascular smooth muscle cell senescence in atherosclerosis
  415. How might replicative senescence contribute to human ageing?
  416. Age-related changes in learning and memory in the senescence-accelerated mouse (SAM)
  417. Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress
  418. INDIVIDUAL DIFFERENCES, LONGEVITY, AND REPRODUCTIVE senescence IN BIGHORN EWES
  419. DNA damage checkpoint kinase Chk2 triggers replicative senescence
  420. Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and senescence
  421. Targets of the WRKY53 transcription factor and its role during leaf senescence in Arabidopsis
  422. Reversal of senescence in Mouse Fibroblasts through Lentiviral Suppression of p53
  423. senescence‐associated proteases in plants
  424. Cigarette Smoke Induces senescence in Alveolar Epithelial Cells
  425. senescence-Associated Exosome Release from Human Prostate Cancer Cells
  426. Aging and Cancer: The Double‐Edged Sword of Replicative senescence
  427. The evolution of premature reproductive senescence and menopause in human females
  428. senescence of an Antibody-forming Cell Clone
  429. miR-22 represses cancer progression by inducing cellular senescence
  430. Telomerase Inhibition, Telomere Shortening, and senescence of Cancer Cells by Tea Catechins
  431. cGAS is essential for cellular senescence
  432. Effect of Kinetin on Protein & Nucleic Acid Metabolism in Xanthium Leaves During senescence
  433. A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
  434. Retardation of the senescence of Cultured Human Diploid Fibroblasts by Carnosine
  435. Plant senescence
  436. Immune Activation and CD8+ T-Cell Differentiation towards senescence in HIV-1 Infection
  437. Telomere Shortening Triggers senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a
  438. Mitogen‐activated protein kinase p38 defines the common senescence‐signalling pathway
  439. Werner syndrome protein limits MYC-induced cellular senescence
  440. Identification of senescence-associated genes from daylily petals
  441. Cellular senescence in naevi and immortalisation in melanoma: a role for p16?
  442. Leaf senescence and nutrient remobilisation in barley and wheat
  443. Stay-green regulates chlorophyll and chlorophyll-binding protein degradation during senescence
  444. Overcoming cellular senescence in human cancer pathogenesis
  445. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
  446. PHOTOCONTROL OF LEAF senescence
  447. Hallmarks of Cellular senescence
  448. Inhibition of p21‐mediated ROS accumulation can rescue p21‐induced senescence
  449. Vascular cell senescence and vascular aging
  450. The p16INK4a-RB pathway : molecular link between cellular senescence and tumor suppression
  451. T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
  452. Loss of linker histone H1 in cellular senescence
  453. Fibroblasts cultured from venous ulcers display cellular characteristics of senescence
  454. senescence and programmed cell death: substance or semantics?
  455. Rapid induction of senescence in human cervical carcinoma cells
  456. Networking senescence-Regulating Pathways by Using Arabidopsis Enhancer Trap Lines
  457. Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
  458. DOES INCREASED MORTALITY FAVOR THE EVOLUTION OF MORE RAPID senescence?
  459. Relation between senescence and stomatal opening: senescence in darkness
  460. Measuring senescence in wild animal populations: towards a longitudinal approach
  461. Cell senescence in the Aging Kidney
  462. p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC
  463. Replicative senescence and Cell Immortality: The Role of Telomeres and Telomerase
  464. Cellular senescence, ageing and disease
  465. Effect of sugar-induced senescence on gene expression and implications for the regulation of senescence in Arabidopsis
  466. Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
  467. Victorin Induction of an Apoptotic/senescence–like Response in Oats
  468. The oxidative hypothesis of senescence
  469. Accumulation of Short Telomeres in Human Fibroblasts Prior to Replicative senescence
  470. Stress-induced Premature senescence (SIPS)
  471. Significant Role for p16INK4a in p53-Independent Telomere-Directed senescence
  472. Is β-Galactosidase Staining a Marker of senescence in Vitro and in Vivo?
  473. Role of polyamines and ethylene as modulators of plant senescence
  474. Aging and Immortality: Quasi-Programmed senescence and Its Pharmacologic Inhibition
  475. Ovarian Dynamics in Heliconiine Butterflies: Programmed senescence versus Eternal Youth
  476. Inflammatory signaling and cellular senescence
  477. PROTEIN SYNTHESIS AND DEGRADATION DURING AGING AND senescence
  478. Extracellular Invertase Is an Essential Component of Cytokinin-Mediated Delay of senescence
  479. Physical activity and immune senescence in men.
  480. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
  481. Mitochondrial Dysfunction Induces senescence with a Distinct Secretory Phenotype
  482. Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast
  483. Regulation of mitochondrial respiration in senescence
  484. Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature senescence
  485. Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced senescence
  486. Role of Cytokinins in Carnation Flower senescence
  487. Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes
  488. The roles of senescence and telomere shortening in cardiovascular disease
  489. Vertical saccades in senescence.
  490. Variations in senescence and Longevity Include the Possibility of Negligible senescence
  491. Lipid turnover during senescence
  492. Mechanisms of endothelial senescence
  493. Natural senescence of Pea Leaves (An Activated Oxygen-Mediated Function for Peroxisomes)
  494. Water Stress during Seed Filling and Leaf senescence in Soybean
  495. Stress-induced premature senescence and tissue ageing
  496. Increase of deleted mitochondrial DNA in the striatum in Parkinson’s disease and senescence
  497. Defining cellular senescence in IMR-90 cells: a flow cytometric analysis
  498. Cellular senescence mechanisms in chronic wound healing
  499. Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation
  500. The role of CD8+ T‐cell replicative senescence in human aging
  501. Telomere Erosion and senescence in Human Articular Cartilage Chondrocytes
  502. Cellular senescence and DNA synthesis: Thymidine incorporation as a measure of population age in human diploid cells
  503. A Novel Role for High-Mobility Group A Proteins in Cellular senescence and Heterochromatin Formation
  504. Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular senescence
  505. Signal transduction in leaf senescence
  506. senescence in seeds.
  507. Growth stimulation leads to cellular senescence when the cell cycle is blocked
  508. Epidermal differentiation, apoptosis, and senescence: common pathways?
  509. Cellular senescence in the glaucomatous outflow pathway
  510. Leaf senescence Is Delayed in Tobacco Plants Expressing the Maize Homeobox Gene knotted1 under the Control of a senescence-Activated Promoter
  511. Induction of cellular senescence in immortalized cells by human chromosome 1
  512. senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells
  513. Stabilization of Oat Leaf Protoplasts through Polyamine-mediated Inhibition of senescence
  514. Androgens in male senescence
  515. Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a
  516. Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence
  517. Programmed Cell Death during Pollination-Induced Petal senescence in Petunia
  518. Developmental and age-related processes that influence the longevity and senescence of photosynthetic tissues in arabidopsis.
  519. Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?
  520. Reactive oxygen species and oxidative burst: Roles in stress, senescence and signal transducation in plants
  521. Molecular and Biochemical Characterization of Postharvest senescence in Broccoli
  522. TWIN STUDIES ON senescence
  523. senescence of the Human Immune System
  524. Longevity and senescence in plants
  525. senescence‐specific regulation of catalases in Arabidopsis thaliana (L.) Heynh
  526. Extended culture of mouse embryo cells without senescence: inhibition by serum
  527. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes
  528. Desiccation, Flight, Glycogen, and Postponed senescence in Drosophila metanogaster
  529. Klotho as a regulator of oxidative stress and senescence
  530. Twisted epithelial–mesenchymal transition blocks senescence
  531. BENZYLADENINE EFFFCTS ON BEAN LEAF GROWTH AND senescence
  532. The Strategy of senescence
  533. Differences in gene expression between natural and artificially induced leaf senescence
  534. Aging and Replicative senescence Have Related Effects on Human Stem and Progenitor Cells
  535. Requirement for p27KIP1 in Retinoblastoma Protein-Mediated senescence
  536. Replicative senescence in Human Uroepithelial Cells
  537. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
  538. Superoxide Dismutase 1 Knock-down Induces senescence in Human Fibroblasts
  539. Cellular senescence in vivo: Its relevance in ageing and cardiovascular disease
  540. Evolutionary Perspectives on Human senescence
  541. T Cell Replicative senescence in Human Aging
  542. Possible Mechanisms of Adaptive Leaf senescence
  543. Sorghum stay-green QTL individually reduce post-flowering drought-induced leaf senescence
  544. senescence Mutants of Saccharomyces cerevisiae With a Defect in Telomere Replication Identify Three Additional EST Genes
  545. senescence AND REPRODUCTIVE VALUE IN SPARROWHAWKS
  546. Understanding insect life histories and senescence through a resource allocation lens
  547. Klotho suppresses RIG-I-mediated senescence-associated inflammation
  548. Cardiac Muscle Changes in senescence
  549. Ethylene as a Regulator of senescence in Tobacco Leaf Discs
  550. Aspirin reduces endothelial cell senescence
  551. senescence IN NATURAL POPULATIONS OF MAMMALS: A REANALYSIS
  552. Growth and senescence of antibody‐forming cells
  553. Regulation of a senescence Checkpoint Response by the E2F1 Transcription Factor and p14ARF Tumor Suppressor
  554. INK4a-de®cient human diploid ®broblasts areresistant to RAS-induced senescence
  555. Response of a primary human fibroblast cell line to H2O2: senescence-like growth arrest or apoptosis?
  556. A senescence-like Phenotype Distinguishes Tumor Cells That Undergo Terminal Proliferation Arrest after Exposure to Anticancer Agents
  557. Cdk2 suppresses cellular senescence induced by the c-myc oncogene
  558. Identification of a promoter region responsible for the senescence-specific expression of SAG12
  559. Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix
  560. ANTAGONISTIC PLEIOTROPY, MORTALITY SOURCE INTERACTIONS, AND THE EVOLUTIONARY THEORY OF senescence
  561. Wound chronicity and fibroblast senescence – implications for treatment
  562. Insect thermal tolerance: what is the role of ontogeny, ageing and senescence?
  563. THE CORRELATION BETWEEN OXIDATIVE STRESS AND LEAF senescence DURING PLANT DEVELOPMENT #
  564. p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype
  565. Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells
  566. Effect of Pod Removal on Leaf senescence in Soybeans
  567. On the senescence of ovules in cherries
  568. OsNAP connects abscisic acid and leaf senescence by fine-tuning abscisic acid biosynthesis and directly targeting senescence-associated genes in rice
  569. Acceleration of senescence in the collared flycatcher Ficedula albicollis by reproductive costs
  570. Rapid and costly ageing in wild male flies
  571. Transcription Analysis of Arabidopsis Membrane Transporters and Hormone Pathways during Developmental and Induced Leaf senescence
  572. Role of p14ARF in Replicative and Induced senescence of Human Fibroblasts
  573. Leaf senescence and Starvation-Induced Chlorosis Are Accelerated by the Disruption of an Arabidopsis Autophagy Gene
  574. The Role of Protein Synthesis in the senescence of Leaves
  575. Emergence, Elongation, and senescence of Maize Silks
  576. Hemangioblastic Derivatives from Human Induced Pluripotent Stem Cells Exhibit Limited Expansion and Early senescence
  577. Immune senescence
  578. Glucose-Induced Replicative senescence in Mesenchymal Stem Cells
  579. p63 deficiency activates a program of cellular senescence and leads to accelerated aging
  580. Weak p53 permits senescence during cell cycle arrest
  581. Aging and sensory senescence.
  582. Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer
  583. Tumour suppression by p53: the importance of apoptosis and cellular senescence
  584. Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells
  585. Does a Sentinel or a Subset of Short Telomeres Determine Replicative senescence?
  586. Markers for hypersensitive response and senescence show distinct patterns of expression
  587. The role of nuclear lamin B1 in cell proliferation and senescence
  588. Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis
  589. Post‐traumatic osteoarthritis: The role of accelerated chondrocyte senescence
  590. senescence and the healing rates of venous ulcers
  591. The senescence‐Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells
  592. senescence and Receptivity of Maize Silks
  593. Molecular signature of oncogenic ras-induced senescence
  594. senescence and Embedded-Figure Performance in Vision and Touch
  595. Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells
  596. Role of calcium in ripening and senescence
  597. Pheophytin Pheophorbide Hydrolase (Pheophytinase) Is Involved in Chlorophyll Breakdown during Leaf senescence in Arabidopsis
  598. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
  599. Id-1 Delays senescence but Does Not Immortalize Keratinocytes
  600. Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular senescence
  601. Cellular aging and senescence
  602. Mitochondrial production of pro-oxidants and cellular senescence
  603. p16INK4a can initiate an autonomous senescence program
  604. Genetic analysis of cellular senescence
  605. A comparison of the expression patterns of several senescence-associated genes in response to stress and hormone treatment
  606. Replicative senescence Revisited
  607. Evolution of accelerated senescence in laboratory populations of Drosophila
  608. Cytoplasmic chromatin triggers inflammation in senescence and cancer
  609. Hormone-directed Transport of Metabolites and its possible Role in Plant senescence
  610. The evolution of senescence in fish
  611. senescence‐associated lncRNAs: senescence‐associated long noncoding RNAs
  612. Regulation of Leaf senescence by Cytokinin, Sugars, and Light
  613. Cellular senescence in the pathogenesis of benign prostatic hyperplasia
  614. A causal link between respiration and senescence in Podospora anserina
  615. Early Compositional Changes during Postharvest senescence of Broccoli
  616. HDA6 is required for jasmonate response, senescence and flowering in Arabidopsis
  617. Arabidopsis Cytokinin Receptor Mutants Reveal Functions in Shoot Growth, Leaf senescence, Seed Size, Germination, Root Development, and Cytokinin Metabolism
  618. Leaf senescence and activities of the antioxidant enzymes
  619. Cellular senescence drives age-dependent hepatic steatosis
  620. Cloning and characterization of tomato leaf senescence-related cDNAs
  621. Role of Telomerase in Cell senescence and Oncogenesis
  622. Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands
  623. senescence in fishes
  624. Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways
  625. CD28 extinction in human T cells: altered functions and the program of T‐cell senescence
  626. Mitochondrial Dysfunction in the senescence Accelerated Mouse (SAM)
  627. Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts
  628. Adriamycin-induced senescence in Breast Tumor Cells Involves Functional p53 and Telomere Dysfunction
  629. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8
  630. senescence in natural populations of animals: Widespread evidence and its implications for bio-gerontology
  631. Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence.
  632. The Control of Autumn senescence in European Aspen
  633. Genetic regulation of primitive hematopoietic stem cell senescence
  634. DNA fragmentation is regulated by ethylene during carpel senescence in Pisum sativum
  635. AUXIN RESPONSE FACTOR1 and AUXIN RESPONSE FACTOR2 regulate senescence and floral organ abscission in Arabidopsis thaliana
  636. p63–microRNA feedback in keratinocyte senescence
  637. Role of the Ascorbate-Glutathione Cycle of Mitochondria and Peroxisomes in the senescence of Pea Leaves
  638. Effects of PSAG12-IPT Gene Expression on Development and senescence in Transgenic Lettuce
  639. Involvement of free radicals in ageing: a consequence or cause of senescence
  640. The Remobilization of Nitrogen Related to Leaf Growth and senescence in Rice Plants (Oryza sativa L.)
  641. NF-κB inhibition delays DNA damage–induced senescence and aging in mice
  642. Decreased beta-adrenergic responsiveness during senescence.
  643. Membrane phospholipid catabolism and Ca2+ activity in control of senescence
  644. Mechanism of Monocarpic senescence in Rice
  645. Oxidative stress occurs during soybean nodule senescence
  646. Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.
  647. Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence
  648. High levels of antioxidant enzymes correlate with delayed senescence in nonnetted muskmelon fruits
  649. Relationship between Photosynthesis and Chlorophyll Content during Leaf senescence of Rice Seedlings
  650. The Role of Ethylene in the senescence of Oat Leaves
  651. Splicing into senescence: The Curious Case of p16 and p19ARF
  652. The Gene Expression Program of Prostate Fibroblast senescence Modulates Neoplastic Epithelial Cell Proliferation through Paracrine Mechanisms
  653. Cellular senescence and chromatin organisation
  654. Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53
  655. Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence
  656. DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?
  657. Ageing, telomeres, senescence, and liver injury
  658. Evidence That Aging And Amyloid Promote Microglial Cell senescence
  659. Cellular senescence and DNA repair
  660. Rethinking the evolutionary theory of aging: Transfers, not births, shape senescence in social species
  661. Vascular Smooth Muscle Cells Undergo Telomere-Based senescence in Human Atherosclerosis
  662. Assessing Cell and Organ senescence Biomarkers
  663. Molecular Regulation of Melanocyte senescence
  664. Premature senescence of endothelial cells: Methusaleh’s dilemma
  665. Resistance to Environmental Stress in Drosophila melanogaster Selected for Postponed senescence
  666. Oxidative stress induces senescence in chondrocytes
  667. p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
  668. HIF1α delays premature senescence through the activation of MIF
  669. Retardation of leaf senescence by benzyladenine in intact bean plants
  670. Cellular senescence and the aging brain
  671. Carnosine as a Potential Anti-senescence Drug
  672. The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15Ink4b
  673. Cellular aging–clonal senescence. A review (Part I)
  674. Is Accelerated senescence a Cost of Reproduction?
  675. Astrocytes in the aging brain express characteristics of senescence‐associated secretory phenotype
  676. MicroRNAs linking inflamm-aging, cellular senescence and cancer
  677. senescence-associated inflammatory responses: aging and cancer perspectives
  678. Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53‐dependent cellular senescence
  679. Altered fruit ripening and leaf senescence in tomatoes expressing an antisense ethylene‐forming enzyme transgene
  680. Antioxidants Inhibit Nuclear Export of Telomerase Reverse Transcriptase and Delay Replicative senescence of Endothelial Cells
  681. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
  682. Evidence that exposure of the telomere 3′ overhang sequence induces senescence
  683. Physiological compensation for loss of afferent synapses in rat hippocampal granule cells during senescence.
  684. Ribulose Bisphosphate Carboxylase and Proteolytic Activity in Wheat Leaves from Anthesis through senescence
  685. Spontaneous age-associated amyloidosis in senescence-accelerated mouse (SAM)
  686. Cellular senescence: Molecular Mechanisms, In Vivo Significance, and Redox Considerations
  687. Overexpression of Arabidopsis Hexokinase in Tomato Plants Inhibits Growth, Reduces Photosynthesis, and Induces Rapid senescence
  688. senescence induction; a possible cancer therapy
  689. Cell senescence and Its Implications for Nephrology
  690. Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation
  691. Central Role of the Proteasome in senescence and Survival of Human Fibroblasts
    INDUCTION OF A senescence-LIKE PHENOTYPE UPON ITS INHIBITION AND RESISTANCE TO STRESS UPON ITS ACTIVATION
  692. Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of senescence and Differentiation in Human Fibroblasts
  693. senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts.
  694. Characteristics of age-related behavioral changes in senescence-accelerated mouse SAMP8 and SAMP10
  695. Mammalian Prohibitin Proteins Respond to Mitochondrial Stress and Decrease during Cellular senescence
  696. Antisense suppression of phospholipase D alpha retards abscisic acid- and ethylene-promoted senescence of postharvest Arabidopsis leaves.
  697. Autophagy, senescence and tumor dormancy in cancer therapy
  698. senescence of immune defence in Bombus workers
  699. senescence-Induced Serotonin Biosynthesis and Its Role in Delaying senescence in Rice Leaves
  700. Role of T lymphocyte replicative senescence in vaccine efficacy
  701. Dental senescence in a long-lived primate links infant survival to rainfall
  702. The influence of sward condition on rates of herbage growth and senescence in mixed swards under continuous stocking management
  703. Cytokinin Activity in Rose Petals and Its Relation to senescence
  704. Evidence for Multiple Pathways to Cellular senescence
  705. Arabidopsis Nitric Oxide Synthase1 Is Targeted to Mitochondria and Protects against Oxidative Damage and Dark-Induced senescence
  706. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and senescence in Neuroblastoma
  707. Cellular senescence in cancer treatment: friend or foe?
  708. Human chondrocyte senescence and osteoarthritis
  709. Spectral Reflectance Changes Associated with Autumn senescence of Aesculus hippocastanum L. and Acer platanoides L. Leaves. Spectral Features and Relation to Chlorophyll Estimation
  710. BULB-TYPE FLOWER senescence
  711. Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms
  712. Protein oxidation and degradation during postmitotic senescence
  713. Doubling potential, calendar time, and senescence of human diploid cells in culture
  714. Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1/Yit strain
  715. Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis
  716. mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
  717. senescence Is Induced in Individually Darkened Arabidopsis Leaves, but Inhibited in Whole Darkened Plants
  718. Hypoxia suppresses conversion from proliferative arrest to cellular senescence
  719. RNS2: a senescence-associated RNase of Arabidopsis that diverged from the S-RNases before speciation
  720. Interleukin‐22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice
  721. Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts
  722. Evolutionary Biology of senescence
  723. Eating to exit: autophagy-enabled senescence revealed
  724. Loss of CD28 expression on T lymphocytes: A marker of replicative senescence
  725. senescence‐associated vacuoles with intense proteolytic activity develop in leaves of Arabidopsis and soybean
  726. senescence-associated beta-galactosidase histochemistry for the primate eye.
  727. Cytokine loops driving senescence
  728. MicroRegulators come of age in senescence
  729. DNA end joining becomes less efficient and more error-prone during cellular senescence
  730. Conditional senescence in bacteria: death of the immortals
  731. senescence and Death of Primitive Cells and Myocytes Lead to Premature Cardiac Aging and Heart Failure
  732. Isolation and analysis of cDNAs encoding tomato cysteine proteases expressed during leaf senescence
  733. Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species
  734. Mate Choice, Sexual Conflict, and Evolution of senescence
  735. Markers of cellular senescence. Telomere shortening as a marker of cellular senescence
  736. Stress-Induced Legume Root Nodule senescence. Physiological, Biochemical, and Structural Alterations
  737. Chlorophyll b reduction during senescence of barley seedlings
  738. Categories of Petal senescence and Abscission: A Re-evaluation
  739. Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a senescence-like Arrest Mediated by p27Kip1
  740. Relation between Nitrogen and Ribulose-1,5-bisphosphate Carboxylase in Rice Leaves from Emergence through senescence
  741. ETHYLENE-INSENSITIVE3 Is a senescence-Associated Gene That Accelerates Age-Dependent Leaf senescence by Directly Repressing miR164 Transcription in Arabidopsis
  742. TP53 and MTOR crosstalk to regulate cellular senescence
  743. senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans
  744. Physiological and pathological consequences of cellular senescence
  745. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
  746. senescence from G2 arrest, revisited
  747. ORS1, an H2O2-Responsive NAC Transcription Factor, Controls senescence in Arabidopsis thaliana
  748. THE KINETICS OF senescence
  749. Arbuscular mycorrhizal symbiosis can alleviate drought‐induced nodule senescence in soybean plants
  750. High-Resolution Temporal Profiling of Transcripts during Arabidopsis Leaf senescence Reveals a Distinct Chronology of Processes and Regulation
  751. The evolution of senescence from a comparative perspective
  752. Relationship between Ethylene Evolution and senescence in Morning-Glory Flower Tissue
  753. WRKY22 transcription factor mediates dark-induced leaf senescence in Arabidopsis
  754. senescence of nickel-transformed cells by an X chromosome: possible epigenetic control
  755. Hydrogen sulfide acts as a regulator of flower senescence in plants
  756. Gene expression during anthesis and senescence in Iris flowers
  757. Induced senescence of Intact Wheat Seedlings and Its Reversibility
  758. Oncogene-induced senescence: the bright and dark side of the response
  759. miR-29 and miR-30 regulate B-Myb expression during cellular senescence
  760. Negligible senescence during Reproductive Dormancy in Drosophila melanogaster
  761. Delayed Leaf senescence in Tobacco Plants Transformed with tmr, a Gene for Cytokinin Production in Agrobacterium.
  762. Monitoring Tumorigenesis and senescence In Vivo with a p16INK4a-Luciferase Model
  763. Endothelial Cell senescence
  764. Hormonal changes during salinity-induced leaf senescence in tomato (Solanum lycopersicum L.)
  765. Short Periods of Water Stress during Seed Filling, Leaf senescence, and Yield of Soybean
  766. senescence, nutrient remobilization, and yield in wheat and barley
  767. senescence and the Genetic-Correlation Hang-Up
  768. REVIEW ARTICLE. p53: GUARDIAN OF CELLULAR senescence
  769. Phospholipase D in cellular senescence
  770. Rice NON-YELLOW COLORING1 Is Involved in Light-Harvesting Complex II and Grana Degradation during Leaf senescence
  771. Delayed leaf senescence in ethylene‐deficient ACC‐oxidase antisense tomato plants: molecular and physiological analysis
  772. Source : sink ratio and leaf senescence in maize:: I. Dry matter accumulation and partitioning during grain filling
  773. Carotenoid catabolism during leaf senescence and its control by light
  774. senescence: does it all happen at the ends?
  775. Oxidative stress induces senescence in human mesenchymal stem cells
  776. DNA damage, vascular senescence and atherosclerosis
  777. Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
  778. DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion
  779. Role of p21 in Apoptosis and senescence of Human Colon Cancer Cells Treated with Camptothecin
  780. Oxygen free radicals in cell senescence: Are they signal transducers?
  781. Genetics of cellular senescence
  782. Regulation of E2Fs and senescence by PML nuclear bodies
  783. Cellular senescence and cancer chemotherapy resistance
  784. RNA Interference of Human Papillomavirus Type 18 E6 and E7 Induces senescence in HeLa Cells
  785. senescence and immortality in hepatocellular carcinoma
  786. senescence Processes in Leaf Abscission
  787. Acceleration of Membrane senescence in Cut Carnation Flowers by Treatment with Ethylene
  788. Oncogenic functions of tumour suppressor p21Waf1/Cip1/Sdi1: association with cell senescence and tumour-promoting activities of stromal fibroblasts
  789. WRKY54 and WRKY70 co-operate as negative regulators of leaf senescence in Arabidopsis thaliana
  790. Calcium regulation of senescence in rose petals
  791. Leaf senescence in Brassica napus: expression of genes encoding pathogenesis-related proteins
  792. Leaf senescence in maize hybrids: plant population, row spacing and kernel set effects
  793. The Effects of Ear Removal on senescence and Metabolism of Maize
  794. Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?
  795. Asexual metazoans undergo senescence.
  796. The biochemistry and regulation of senescence in chloroplasts
  797. Catalase and Peroxidase in Primary Bean Leavesduring Development and senescence
  798. Correlation of Xylem Sap Cytokinin Levels with Monocarpic senescence in Soybean
  799. Induction of senescence by oncogenic ras
  800. Mechanisms of polyamine action during senescence responses induced by osmotic stress
  801. Papillomavirus E2 induces senescence in HPV‐positive cells via pRB‐ and p21CIP‐dependent pathways
  802. Role of Ethylene in the senescence of Detached Rice Leaves
  803. senescence, Stress, and Reactive Oxygen Species
  804. A Role for Glutamine Synthetase in the Remobilization of Leaf Nitrogen during Natural senescence in Rice Leaves
  805. Predatory senescence in ageing wolves
  806. Hydrogen Sulfide Protects Against Cellular senescence via S-Sulfhydration of Keap1 and Activation of Nrf2
  807. Estrogen reduces endothelial progenitor cell senescence through augmentation of telomerase activity
  808. ABA receptor PYL9 promotes drought resistance and leaf senescence
  809. senescence-associated reprogramming promotes cancer stemness
  810. Arabidopsis AtNAP regulates fruit senescence
  811. Reversible senescence in Human CD4+CD45RA+CD27− Memory
  812. T Cell Activation and senescence Predict Subclinical Carotid Artery Disease in HIV-Infected Women
  813. Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition
  814. Evolutionary mechanisms of senescence
  815. Changes in Capsaicinoids during Development, Maturation, and senescence of Chile Peppers and Relation with Peroxidase Activity
  816. The Vacuole and Cell senescence
  817. The role of ubiquitin in plant senescence and stress responses
  818. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly
  819. Induction of senescence in human malignant glioma cells by p16INK4A
  820. Leaf peroxisomes are directly transformed to glyoxysomes during senescence of pumpkin cotyledons
  821. Convergence and divergence in gene expression profiles induced by leaf senescence and 27 senescence‐promoting hormonal, pathological and environmental stress treatments
  822. senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs
  823. Transcriptional regulation of cellular senescence
  824. Molecular and Cell Biology of Replicative senescence
  825. Ethylene-regulated expression of a carnation cysteine proteinase during flower petal senescence
  826. senescence and death of plant organs: Nutrient recycling and developmental regulation
  827. p16Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors
  828. Chemokines Acting via CXCR2 and CXCR4 Control the Release of Neutrophils from the Bone Marrow and Their Return following senescence
  829. The senescence of the Immune System
  830. Telomere-driven replicative senescence is a stress response
  831. Methyl Jasmonate, Calcium, and Leaf senescence in Rice
  832. Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras
  833. Smurf2 up-regulation activates telomere-dependent senescence
  834. Autophagy and senescence
  835. Critical pathways in cellular senescence and immortalization revealed by gene expression profiling
  836. The evolutionary ecology of pre- and post-meiotic sperm senescence
  837. Inhibition of phospholipase D by lysophosphatidylethanolamine, a lipid-derived senescence retardant
  838. Chlorophyll-a degradation during cellular senescence and death
  839. Integrated Signaling in Flower senescence
  840. Mechanisms of Disease: role of chondrocytes in the pathogenesis of osteoarthritis—structure, chaos and senescence
  841. Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
  842. PML interaction with p53 and its role in apoptosis and replicative senescence
  843. Thidiazuron—a potent inhibitor of leaf senescence in Alstroemeria
  844. The disparity between human cell senescence in vitro and lifelong replication in vivo
  845. Ethylene receptor expression is regulated during fruit ripening, flower senescence and abscission
  846. T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection
  847. Expression of Caveolin-1 Induces Premature Cellular senescence in Primary Cultures of Murine Fibroblasts
  848. A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to senescence Suppression in Cancer Cells
  849. Stress-induced premature senescence and replicative senescence are different phenotypes, proteomic evidence
  850. Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)
  851. Endogenous Human Papillomavirus E6 and E7 Proteins Differentially Regulate Proliferation, senescence, and Apoptosis in HeLa Cervical Carcinoma Cells
  852. Transcriptome analysis of senescence in the flag leaf of wheat (Triticum aestivum L.)
  853. Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-κB
  854. The Relation of Autoǵamy to senescence and Rejuvenescence in Paramecium aurelia
  855. senescence and Genetic Load: Evidence from Tribolium
  856. senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
  857. Leaf senescence – not just a ‘wear and tear’ phenomenon
  858. Immune senescence: Mechanisms and Clinical Implications
  859. Involvement of the INK4a/Arf gene locus in senescence
  860. Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-α-phenylnitrone
  861. ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
  862. Errors in Protein Synthesis and Clonal senescence in Fungi
  863. The E3 SUMO Ligase PIASy Is a Regulator of Cellular senescence and Apoptosis
  864. miRNA-205 Suppresses Melanoma Cell Proliferation and Induces senescence via Regulation of E2F1 Protein
  865. Hidden costs of infection: Chronic malaria accelerates telomere degradation and senescence in wild birds
  866. Replicative senescence of CD8 T cells: effect on human ageing
  867. Studies on Soybean Nodule senescence
  868. Cellular senescence: Its role in tumor suppression and aging
  869. Evidence for the function of the free radical gas — nitric oxide (NO•) — as an endogenous maturation and senescence regulating factor in higher plants
  870. AtATG18a is required for the formation of autophagosomes during nutrient stress and senescence in Arabidopsis thaliana
  871. Propagation and senescence of human marrow stromal cells in culture: a simple colony‐forming assay identifies samples with the greatest potential to propagate and differentiate
  872. senescence Regulation by the p53 Protein Family
  873. Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
  874. mTOR Inhibition Prevents Epithelial Stem Cell senescence and Protects from Radiation-Induced Mucositis
  875. Cellular lifespan and senescence signaling in embryonic stem cells
  876. Lung fibroblasts from patients with emphysema show markers of senescence in vitro
  877. Future atmospheric CO2 leads to delayed autumnal senescence
  878. Sugars, senescence, and ageing in plants and heterotrophic organisms
  879. Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation
  880. Mutation and senescence: where genetics and demography meet
  881. miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition
  882. ATR signaling can drive cells into senescence in the absence of DNA breaks
  883. OPTIMALITY THEORY, GOMPERTZ’ LAW, AND THE DISPOSABLE SOMA THEORY OF senescence
  884. Inhibition of ethylene synthesis and senescence in carnation by ethanol.
  885. In vitro simulation of senescence-related membrane damage by ozone-induced lipid peroxidation
  886. Telomere-dependent senescence
  887. Stress-induced senescence in human and rodent astrocytes
  888. The evolutionary basis of leaf senescence: Method to the madness?
  889. Leaf Proteolytic Activities and senescence during Grain Development of Field-grown Corn (Zea mays L.)
  890. Hypoxia, MTOR and autophagy
    Converging on senescence or quiescence
  891. Long‐term exogenous application of melatonin delays drought‐induced leaf senescence in apple
  892. Integration of soybean pod development and monocarpic senescence
  893. Tissue damage and senescence provide critical signals for cellular reprogramming in vivo
  894. Unexpected Pieces to the senescence Puzzle
  895. Cell senescence: Role in Aging and Age-Related Diseases
  896. Disposable-soma senescence mediated by sexual selection in an ungulate
  897. Reactive oxygen species and hematopoietic stem cell senescence
  898. Biochemical changes related to aging in the senescence-accelerated mouse
  899. Programmed senescence of plant organs
  900. SOCS1 Links Cytokine Signaling to p53 and senescence
  901. The role of ascorbic acid in the control of flowering time and the onset of senescence
  902. Autophagy and senescence in Cancer Therapy
  903. Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer
  904. Aging in Legume Symbiosis. A Molecular View on Nodule senescence in Medicago truncatula
  905. A gene regulatory network controlled by the NAC transcription factor ANAC092/AtNAC2/ORE1 during salt‐promoted senescence
  906. DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
  907. Evidence of cell loss from the rat retina during senescence
  908. Evidence for a senescence-Associated Gene Induced by Darkness
  909. Ascorbic acid, a familiar small molecule intertwined in the response of plants to ozone, pathogens, and the onset of senescence
  910. Targeting cellular senescence prevents age-related bone loss in mice
  911. Executing Cell senescence
  912. Aging and senescence in plant developent.
  913. Cortical bone senescence and mineral bone density of the humerus
  914. Control of cellular senescence by CPEB
  915. Morphological and contractile characteristics of rat cardiac myocytes from maturation to senescence
  916. p16/pRb Pathway Alterations Are Required for Bypassing senescence in Human Prostate Epithelial Cells
  917. Vemurafenib Induces senescence Features in Melanoma Cells
  918. Role of growth regulators in the senescence of Arabidopsis thaliana leaves
  919. Pigment dynamics and autumn leaf senescence in a New England deciduous forest, eastern USA
  920. Suppression of tumor growth by senescence in virally transformed human fibroblasts
  921. Factors that accelerate or retard red blood cell senescence.
  922. IndependentInductionofsenescencebyp16INK4
  923. Multiple pathways to cellular senescence: Role of telomerase repressors
  924. Octopus senescence: The Beginning of the End
  925. A new member of the Arabidopsis WRKY transcription factor family, AtWRKY6, is associated with both senescence‐ and defence‐related processes
  926. Demographic Perspectives on Human senescence
  927. Molecular mechanisms of replicative senescence in endothelial cells
  928. Does Maintaining Green Leaf Area in Sorghum Improve Yield under Drought? I. Leaf Growth and senescence
  929. Functional Aging and Gradual senescence in Zebrafish
  930. A reassessment of the telomere hypothesis of senescence
  931. Interrelationships of Ethylene and Abscisic Acid in the Control of Rose Petal senescence
  932. Promotive Effect of Methyl Jasmonate on Oat Leaf senescence in the Light
  933. senescence in podospora anserina: Amplification of a mitochondrial DNA sequence
  934. Evolution of senescence in iteroparous perennial plants
  935. Comparison of replicative senescence and stress‐induced premature senescence combining differential display and low‐density DNA arrays
  936. POLLINATION-INDUCED COROLLA senescence
  937. The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A–ARF locus in response to oncogene- and stress-induced senescence
  938. Legume nodule senescence: roles for redox and hormone signalling in the orchestration of the natural aging process
  939. Mitochondrial-Targeted Plastoquinone Derivatives. Effect on senescence and Acute Age-Related Pathologies
  940. Dark‐inducible genes from Arabidopsisthaliana are associated with leaf senescence and repressed by sugars
  941. Nitric oxide counteracts the senescence of rice leaves induced by abscisic acid
  942. Cellular senescence in Type 2 Diabetes: A Therapeutic Opportunity
  943. senescence of the retinal pigment epithelium
  944. senescence-related serine protease in parsley
  945. The Metabolism of Oat Leaves during senescence
  946. Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence.
  947. Markers of senescence?
  948. Repair of telomeric DNA prior to replicative senescence
  949. Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney
  950. Regulation of detached coriander leaf senescence by 1-methylcyclopropene and ethylene
  951. Stress-Activated MAP Kinase Cascades in Cellular senescence
  952. Cellular senescence in Vitro
  953. Inhibition of ethylene‐induced cellular senescence symptoms by 1‐methylcyclopropene, a new inhibitor of ethylene action
  954. The Complex Regulation of senescence
  955. Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence
  956. Delayed senescence of apple leaves by exogenous melatonin treatment: toward regulating the ascorbate–glutathione cycle
  957. High Levels of Brain Dolichols in Neuronal Ceroid‐Lipofuscinosis and senescence
  958. An anti-aging drug today: from senescence-promoting genes to anti-aging pill
  959. Homocysteine accelerates senescence and reduces proliferation of endothelial progenitor cells
  960. Posttranslational Modifications of p53 in Replicative senescence Overlapping but Distinct from Those Induced by DNA Damage
  961. Aging, life span, and senescence
  962. The Role of Arabidopsis Rubisco Activase in Jasmonate-Induced Leaf senescence
  963. Connecting autophagy to senescence in pathophysiology
  964. Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts
  965. miR-335 and miR-34a Promote Renal senescence by Suppressing Mitochondrial Antioxidative Enzymes
  966. senescence-Accelerated Mouse (SAM) with Special References to Neurodegeneration Models, SAMP8 and SAMP10 Mice
  967. Glycated Collagen I Induces Premature senescence-Like Phenotypic Changes in Endothelial Cells
  968. Image analysis of GFA-positive astrocytes from adolescence to senescence
  969. Escape from Therapy-Induced Accelerated Cellular senescence in p53-Null Lung Cancer Cells and in Human Lung Cancers
  970. Cloning of senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen
  971. Localization of senescent cell antigen on band 3
  972. A senescent cell bystander effect: senescence‐induced senescence
  973. senescent cell antigen is immunologically related to band 3
  974. Measurement of DNA content and cell volume in senescent human fibroblasts utilizing flow multiparameter single cell analysis
  975. A New LIM Protein Containing an Autoepitope Homologous to “senescent Cell Antigen”
  976. Generation of senescent cell antigen on old cells initiates IgG binding to a neoantigen.
  977. Mimetics of senescent cell derived inhibitors of DNA synthesis
  978. senescent Keratinocytes Die by Autophagic Programmed Cell Death
  979. Rapid disappearance of statin, a nonproliferating and senescent cell-specific protein, upon reentering the process
  980. Molecular Mechanisms for the senescent Cell Cycle Arrest
  981. Membrane Fragmentation and Ca++-Membrane Interaction : Potential Mechanisms of Shape Change in the senescent Red Cell
  982. Long-Term in vitro Growth of Human T Cell Clones: Can Postmitotic ‘senescent’ Cell Populations Be Defined?
  983. senescent cell derived inhibitors of DNA synthesis
  984. Antigenicity, storage, and aging: physiologic autoantibodies to cell membrane and serum proteins and the senescent cell antigen
  985. Aging of Cell Membrane Molecules Leads to Appearance of an Aging Antigen and Removal of senescent cells
  986. Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice
  987. Inhibition of intimal hyperplasia after vein grafting by in vivo transfer of human senescent cell-derived inhibitor-1 gene
  988. Identification of senescent cell surface targetable protein DPP4
  989. Synthetic senescent cell antigen
  990. senescent vs. non-senescent cells in the human annulus in vivo: Cell harvest with laser capture microdissection and gene expression studies with microarray analysis
  991. senescent cell derived inhibitors of DNA synthesis
  992. Glucose transport protein is structurally and immunologically related to band 3 and senescent cell antigen
  993. senescent Human Fibroblasts Resist Programmed Cell Death, and Failure to Suppress bcl2 Is Involved
  994. Duration of senescent cell survival in vitro as a characteristic of organism longevity, an additional to the proliferative potential of fibroblasts
  995. Antibodies to senescent cell-derived inhibiters of DNA synthesis
  996. Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts
  997. Induction of senescent cell-derived inhibitor of DNA synthesis gene, SDI1, in hepatoblastoma (HepG2) cells arrested in the G2-phase of the cell cycle by 9-nitrocamptothecin.
  998. Relationship between cell replication and volume in senescent human diploid fibroblasts
  999. p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling
  1000. Cell-Cell Affinity of senescent Human Erythrocytes
  1001. The Ability to Generate senescent Progeny as a Mechanism Underlying Breast Cancer Cell Heterogeneity
  1002. senescent and quiescent cell inhibitors of DNA synthesis: Membrane-associated proteins
  1003. Pseudomonas aeruginosa Transmigrates at Epithelial Cell-Cell Junctions, Exploiting Sites of Cell Division and senescent Cell Extrusion
  1004. senescent cell antigen, band 3, and band 3 mutations in cellular aging.
  1005. SCAMP4 enhances the senescent cell secretome
  1006. senescent cell differentiation antigen.
  1007. Reinitiation of DNA Synthesis and Cell Division in senescent Human Fibroblasts by Microinjection of Anti-p53 Antibodies
  1008. Aging of cell membrane molecules: Band 3 and senescent cell antigen in neural tissue
  1009. Impaired Cell Shortening and Relengthening with Increased Pacing Frequency are Intrinsic to the senescent Mouse Cardiomyocyte
  1010. Dynamics of senescent Cell Formation and Retention Revealed by p14ARF Induction in the Epidermis
  1011. Entry into S phase is inhibited in two immortal cell lines fused to senescent human diploid cells
  1012. senescent cell death brings hopes to life
  1013. Common senescent cell‐specific antibody epitopes on fibronectin in species and cells of varied origin
  1014. senescent cell derived inhibitors of DNA synthesis
  1015. Restoration of the responsiveness to growth factors in senescent cells by an embryonic cell extract
  1016. MnSOD Upregulation Induces Autophagic Programmed Cell Death in senescent Keratinocytes
  1017. Spontaneous cell transformation: Karyoplasts derived from multinucleated cells produce new cell growth in senescent human epithelial cell cultures
  1018. senescent cell antigen: a terminal differentiation antigen.
  1019. Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2
  1020. Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death
  1021. Molecular Mapping of the Active Site of an Aging Antigen: senescent Cell Antigen Requires Lysine(s) for Antigenicity and Is Located on an Anion-Binding Segment of Band 3 Membrane Transport Protein
  1022. Human platelet lysate stimulates high-passage and senescent human multipotent mesenchymal stromal cell growth and rejuvenation in vitro
  1023. Gerontology and drug development: The challenge of the senescent cell
  1024. Chlorophyll Degradation in senescent Tobacco Cell Culture (Nicotiana tabacum var. «Samsun»)
  1025. Down-regulation of Akt/PKB in senescent cardiac fibroblasts impairs PDGF-induced cell proliferation
  1026. Type 1 interferons contribute to the clearance of senescent cell
  1027. Robust nuclear lamina-based cell classification of aging and senescent cells
  1028. Simvastatin suppresses breast cancer cell proliferation induced by senescent cells
  1029. Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype
  1030. Appearance of the terminal senescent cell population in human diploid fibroblasts analyzed by flow cytometry
  1031. Some chemotherapeutics-treated colon cancer cells display a specific phenotype being a combination of stem-like and senescent cell features
  1032. mRNA levels of the differentiation-associated linker histone variant H1 zero in mitotically active and postmitotic senescent human diploid fibroblast cell populations
  1033. Method To Purify and Analyze Heterogeneous senescent Cell Populations Using a Microfluidic Filter with Uniform Fluidic Profile
  1034. Mapping of senescent cell antigen on brain anion exchanger protein (AE) isoforms using HPLC and fast atom bombardment ionization mass spectrometry (FAB‐MS)
  1035. Evaluation of a near‐senescent human dermal fibroblast cell line and effect of amelogenin
  1036. Level of macroautophagy drives senescent keratinocytes into cell death or neoplastic evasion
  1037. Genes and ageing: beyond good and evil in the senescent cell
  1038. Method of optimizing conditions for selectively removing a plurality of senescent cells from a tissue or a mixed cell population
  1039. Complementation between senescent human diploid cells and a thymidine kinase-deficient murine cell line
  1040. Targeting senescent cholangiocytes and activated fibroblasts with B‐cell lymphoma‐extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/−) mice
  1041. Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice
  1042. Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells
  1043. senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway
  1044. Density-gradient centrifugation enables the purification of cultured corneal endothelial cells for cell therapy by eliminating senescent cells
  1045. senescent cell clearance by the immune system: Emerging therapeutic opportunities
  1046. Life and Death of Neurons: The Role of senescent Cell Antigen
  1047. Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability
  1048. Retroviral vectors carrying senescent cell derived inhibitors 1 (SDI-1)or antisense SDI-1 nucleotide sequences
  1049. In Vitro Expansion of Human Nasoseptal Chondrocytes Reveals Distinct Expression Profiles of G1 Cell Cycle Inhibitors for Replicative, Quiescent, and senescent Culture Stages
  1050. Drug-Induced senescent Multiple Myeloma Cells Elicit NK Cell Proliferation by Direct or Exosome-Mediated IL15 Trans-Presentation
  1051. Radiation-Induced Reprogramming of Pre-senescent Mammary Epithelial Cells Enriches Putative CD44+/CD24−/low Stem Cell Phenotype
  1052. Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation of Bax/Bcl-2 pathway
  1053. The senescent cell epigenome
  1054. CHAPTER 24 – senescent cell antigen and band 3 in aging and disease
  1055. The mTORC1-autophagy pathway is a target for senescent cell elimination
  1056. HPV-16 virions can remain infectious for 2 weeks on senescent cells but require cell cycle re-activation to allow virus entry
  1057. Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth
  1058. Proteomics Analysis of Normal and senescent NG108-15 Cells: GRP78 Plays a Negative Role in Cisplatin-Induced senescence in the NG108-15 Cell Line
  1059. Cell surface oligosaccharide modulation during differentiation: VI. The effect of biomodulation on the senescent and neoplastic cell phenotype
  1060. Induction of Neointimal Formation by Local Gene Transfer of the Antisense senescent Cell-derived Inhibitor 1 (SDI) Delivered With the Needle Injection Catheter
  1061. Antibody Dependent Cell Mediated Cytotoxicity and Phagocytosis of senescent Erythrocytes by Autologous Peripheral Blood Mononuclear Cells
  1062. Phase-space description of the cell cycle: Application to noncycling, senescent, and transformed cells
  1063. Effect of Overproduction of Mitochondrial Uncoupling Protein 2 on Cos7 Cells: Induction of senescent-like Morphology and Oncotic Cell Death
  1064. senescent dermal fibroblasts enhance stem cell migration through CCL2/CCR2 axis
  1065. Red cell aging: senescent cell antigen, band 3, and band 3 mutations associated with cellular dysfunction.
  1066. Rock Inhibition Reduces senescent Cell Size
  1067. The senescent Cell, SC
  1068. senescent Cell Biomarkers
  1069. THE senescent CELL POPULATION WITHIN NEW BONE PRODUCED BY DISTRACTION OSTEOGENESIS
  1070. Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques
  1071. Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion
  1072. [Establishment of senescent cell model in primary rat aortic endothelial cells].
  1073. THE ROLE OF THE RETINOBLASTOMA PROTEIN IN senescent CELL CYCLE EXIT, SURVIVAL, AND MORPHOLOGICAL ALTERATION
  1074. Abstract 453: senescent Cell Depletion via Abt263 Augments Experimental Aortic Aneurysm Progression
  1075. Aging and cancer: Cell non-autonomous effects of senescent fibroblasts on tissue microenvironment
  1076. The senescent cell induced bystander effect
  1077. [senescent cell antigens in the clearance of senescent cells].
  1078. Material-induced senescence (MIS): Fluidity Induces senescent Type Cell Death of Lung Cancer Cells via Insulin-Like Growth Factor Binding Protein 5
  1079. Abstract 361: Effects of Chronic, Intermittent senescent Cell Clearance in Combination with Lipid Lowering on Inflammation in Perivascular Adipose Tissue
  1080. Active, Dormant, or on the Path to Elimination: What Does a senescent Cell Do?
  1081. The connection between the cardiac glycoside‐induced senescent cell morphology and Rho/Rho kinase pathway
  1082. Cloning of animals from senescent cell nuclei–what are the implications for aging research?
  1083. Cell Cycle Traverse and Growth Arrest Control in senescent Human Fibroblasts
  1084. senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
  1085. Aging and cancer: Cell non-autonomous effects of senescent fibroblasts on tissue microenvironment
  1086. Klotho‐mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments
  1087. Hydroxyurea‐induced senescent peripheral blood mesenchymal stromal cells inhibit bystander cell proliferation of JAK2V617F‐positive human erythroleukemia cells
  1088. Aging and cancer: Cell non-autonomous effects of senescent fibroblasts on tissue microenvironment
  1089. Antibodies to senescent Antigen and C3 Are Not Required for Normal Red Blood Cell Lifespan in a Murine Model
  1090. Removing senescent cells from a mixed cell population or tissue using a phosphoinositide 3-kinase (pi3k) inhibitor
  1091. Differential Regulation of Methylation-Regulating Enzymes by senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs
  1092. senescent Pulmonary-Artery Smooth Muscle Cell (PA-SMC)-Derived Osteopontin Promotes PA-SMC Proliferation in Chronic Obstructive Pulmonary Disease
  1093. 303: A role for senescent cell-derived IL6 in HER2+ breast cancer progression
  1094. A New LIM Protein Containing an Autoepitope Homologous to ‘senescent Cell Antigen,’
  1095. Aging and the senescent cell
  1096. Differences between cytotoxicity of chemicals determined in vitro on young and old cells of a senescent cell line
  1097. Modulation of Phenotype and Induction of Apoptosis in Vascular Smooth Muscle Cells (VSMC) by Transfer of Human senescent Cell-Derived Inhibitor-1 Gene: 190
  1098. Adventitial gene transfer of the antisense to senescent cell-derived inhibitor 1 results in increased neointima
  1099. senescent CELL DERIVED INHIBITORS OF DNA SYNTHESIS
  1100. Cell cycle and apoptosis: death of a senescent cell
  1101. MIMETICS OF senescent CELL DERIVED INHIBITORS OF DNA SYNTHESIS
  1102. senescent cell distribution in human skeletal muscle : Role of exercise and protein availability
  1103. A new LIM protein containing an autoepitope homologous to’senescent cell antigen’ (vol 201, pg 1127, 1994)
  1104. Chemotherapeutics-treated cancer cells display stem-like and senescent cell features
  1105. Fisetin is a senotherapeutic that extends health and lifespan
  1106. The emerging field of senotherapeutic drugs
  1107. SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs.
  1108. Src Tyrosine Kinase Inhibitors: New Perspectives on Their Immune, Antiviral, and Senotherapeutic Potential
  1109. Senotherapy: growing old and staying young?
  1110. Senotherapy for attenuation of cellular senescence in aging and organ implantation
  1111. Targeting normal and cancer senescent cells as a strategy of senotherapy
  1112. Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)
  1113. SASP reflects senescence
  1114. SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells
  1115. Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses
  1116. Detection of the senescence-associated secretory phenotype (SASP)
  1117. Melatonin regulates PARP 1 to control the senescence‐associated secretory phenotype (SASP) in human fetal lung fibroblast cells
  1118. Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2
  1119. SASP: tumor suppressor or promoter? Yes!
  1120. The experimental demonstration of a SASP-based full software radio receiver
  1121. Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells
  1122. Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans
  1123. Evaluation of the mutagenicity of the anti-inflammatory drug salicylazosulfapyridine (SASP)
  1124. Whole Chromosome Instability induces senescence and promotes SASP
  1125. SASP gene delivery: a novel antibacterial approach
  1126. Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
  1127. The small acid soluble proteins (SASP α and SASP β) of Bacillus weihenstephanensis and Bacillus mycoides group 2 are the most distinct among the Bacillus cereus …
  1128. ATM, MacroH2A. 1, and SASP: the checks and balances of cellular senescence
  1129. … absorption of 5-aminosalicylic acid (5-ASA) after administration of a 5-ASA enema and salazosulfapyridine (SASP) after an SASP suppository in Japanese volunteers
  1130. SASP (Small, Acid-Soluble Spore Proteins) and Spore Properties in Bacillus thuringiensis israelensis and Bacillus sphaericus
  1131. Isolation and identification of Lom-SG-SASP, a salivation stimulating peptide from the salivary glands of Locusta migratoria
  1132. Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?
  1133. “Social Life” of Senescent Cells: What Is SASP and Why Study It?
  1134. Synthesis and characterization of a 29-amino acid residue DNA-binding peptide derived from α/β-type small, acid-soluble spore proteins (SASP) of bacteria
  1135. Effects of NAT2 polymorphism on SASP pharmacokinetics in Chinese population
  1136. Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay
  1137. Another classic of EU sports jurisprudence: Legal implications of Olympique Lyonnais SASP v Olivier Bernard and Newcastle UFC (C-325/08)
  1138. Clinical Observation on 30 Cases of Ulcerative Colitis of Damp Heat in the Large Intestine Stagnation Type Treated with Kuijieling Granules Combinated SASP [J]
  1139. SASP regulation by noncoding RNA
  1140. Scavenger effect of sulphasalazine (SASP), 5-aminosalicylic acid (5-ASA), and olsalazine (OAZ)
  1141. SASP, a Senescence-Associated Subtilisin Protease, is involved in reproductive development and determination of silique number in Arabidopsis
  1142. Symbol manipulation in FORTRAN: SASP I subroutines
  1143. Chronic resveratrol treatment inhibits MRC5 fibroblast SASP-related protumoral effects on melanoma cells
  1144. Pharmacokinetics of salazosulfapyridine (Sulfasalazine, SASP)(I): Plasma kinetics and plasma metabolites in the rat after a single intravenous or oral administration
  1145. Sirt1 and Parp1 as epigenome safeguards and microRNAs as SASP-associated signals, in cellular senescence and aging
  1146. SASP, a Production Planning and Control System for Shipbuilding on Individual Orders
  1147. TORn about SASP regulation
  1148. Case C-325/08, Olympique Lyonnais SASP v. Olivier Bernard and Newcastle United UFC, Judgment of the Court of Justice (Grand Chamber) of 16 March 2010
  1149. Beneficial effect of salazosulfapyridine (SASP) in a patient with secondary renal amyloidosis
  1150. Optical design and performance of the SASP spectrometer at TRIUMF
  1151. Detecting the senescence-associated secretory phenotype (SASP) by high content microscopy analysis
  1152. Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP)(V): Pharmacokinetics of SASP after a single intravenous or oral administration in the dog.
  1153. Comparison of SKP (semi-automated kinetic perimetry) and SASP (suprathreshold automated static perimetry) techniques in patients with advanced glaucoma
  1154. SIN3B, the SASP, and pancreatic cancer
  1155. Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP)(III) Metabolism and biliary excretion of SASP in the rat after a single intravenous or oral administration.
  1156. PAI-1 Regulation of TGF-β1-induced ATII Cell Senescence, SASP Secretion, and SASP-mediated Activation of Alveolar Macrophages
  1157. Maintenance treatment of ulcerative colitis (UC) with oral 5-aminosalicylic acid (5-ASA) in patients unable to take sulphasalazine (SASP)
  1158. Observation of curative effect of Sanguis Draxonis combined with SASP in the treatment of non-specific ulcerative colitis
  1159. Replica exchange molecular dynamics simulations of an α/β-type small acid soluble protein (SASP)
  1160. 98: Term fetal membranes and senescence associated secretory phenotype (SASP)-like gene expression: a signal for parturition?
  1161. COMPARATIVE STUDY OF THE EFFECT OF SULPHASALAZINE (SASP) AND 3 5 DIPS ON GLUTATHIONE (GSH) LEVEL IN RED CELLS OF HUMAN BLOOD IN …
  1162. Inhibition of neutral proteases from polymorphonuclear (PMN) neutrophils by salicylazosulfapyridine (SASP)
  1163. Senescence-associated secretory phenotype (SASP) involvement in the development of cancer, aging, and age related diseases
  1164. RNA-binding Protein Immunoprecipitation (RIP) to examine AUF1 binding to senescence-associated secretory phenotype (SASP) factor mRNA
  1165. Modified bacteriophage including an alpha/beta small acid-soluble spore protein (SASP) gene
  1166. Modified bacteriophage including an alpha/beta small acid-soluble spore protein (SASP) gene
  1167. Arabidopsis subtilase SASP is involved in the regulation of ABA signaling and drought tolerance by interacting with OPEN STOMATA 1
  1168. The first experimental demonstration of a SASP-based full Software Radio receiver
  1169. A low power digitally-enhanced SASP-based receiver architecture for mobile DVB-S applications in the Ku-band (10.7–12.75 GHz)
  1170. Senescence can be BETter without the SASP?
  1171. Cancer cell cannibalism and the SASP: Ripples in the murky waters of tumor dormancy
  1172. Methyl caffeate and some plant constituents inhibit age-related inflammation: effects on senescence-associated secretory phenotype (SASP) formation
  1173. Dissecting cellular senescence and SASP in Drosophila
  1174. 169: IL-19, a novel SASP factor, is upregulated during senescence and in response to DSBs
  1175. Growth arrest by sulfasalazine (SASP) of subrenal capsule prostate cancer xenografts in immuno-deficient mice is coupled to a decrease in the number of tumor …
  1176. COMPARISON OF THE EFFICACY OF 5 ASA AND SASP IN TREATMENT OF ULCERATIVE COLITIS
  1177. A La Recherche of Functions for the Spore Protein SASP-E from Bacillus subtilis
  1178. SASP: a symbolic algorithm for shortest paths
  1179. Molecules and Clusters in Motion: Looking Back and Looking Forward, SASP and Beyond
  1180. I no longer dread teaching physics, I now enjoy it!’Participant reflections from the SASP physics course
  1181. The salivary gland salivation stimulating peptide from Locusta migratoria (Lom-SG-SASP) is not a typical neuropeptide
  1182. Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP)(II) Tissue distribution and excretion of SASP in the rat after a single intravenous or oral administration.
  1183. Deciphering the mechanism for induction of senescence-associated secretory phenotype (SASP) and its role in ageing and cancer development
  1184. Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP)
  1185. Overexpression of Klotho Inhibits HELF Fibroblasts SASP-related Protumoral Effects on Non-small Cell Lung Cancer Cells
  1186. SASP-Dependent Interactions between Senescent Cells and Platelets Modulate Migration and Invasion of Cancer Cells
  1187. SKYNET Applications Software Package (SASP) Operators’ and Users’ Handbook, Version 2.
  1188. The rehabilitation village-Paper presented at SASP Congress 1993
  1189. Designing in uncertainty: The I-SASP model for tactical and innovative risk management in the hi-performing professional practice
  1190. Characterization of structural changes in alpha/beta-type small, acid-soluble spore proteins (SASP) upon binding to DNA.
  1191. SASP: The future of School Psychology
  1192. Regulation of the senescence-associated secretory phenotype (SASP)
  1193. Micromanaging fibroblast senescence: The role of small non-coding RNAs in senescence associated secretory phenotype (SASP)
  1194. Effect of sulfasalazine (SASP) on sodium flux in rat colon
  1195. Senescence utilises inflammatory caspases to drive SASP
  1196. Outcome of Patients with Ankylosing Spondyloarthritis Continuing Treated with Thalidomide and SASP after a Short Course of Etanercept Therapy [J]
  1197. Study on Effect of Regulation to Th1/Th2 in AUC Patients with Chinese Medicine Combined with SASP Enema under Guidance of Synchronous Treatment of Lung …
  1198. Effect of combine probiotics with SASP on inflammatory bowel disease
  1199. Changes of T regulatory cells in rats with experimental colitis after drug treatment with SASP and PSL
  1200. Clinical effects of 99Tc-2MDP combined with SASP for ankylosing spondylitis
  1201. Ex-SASP-erating cancer
  1202. ETDEWEB/Search Results/Proceedings of the DASS/SASP (Dual Arm Spectrometer System/Second Arm Spectrometer) workshop
  1203. Immunological Responses and Protection in Dairy Cows Vaccinated with Staphylococcus aureus Surface Proteins (SASP) and Staphylococcus chromogenes …
  1204. Studies on the Role of SASP in Heat and Radiation Resistance of Bacterial Spores and on Regulation of a SASP Specific Protease
  1205. Scavenger effect of sulphasalazine (SASP)
  1206. SASP: targeted delivery to Gram-negative pathogens
  1207. Slow-Release 5-Aminosalicylic Acid (Pentasa) versus Sulphasalazine (SASP) in the Maintenance Treatment of Ulcerative Colitis (82)
  1208. SKYNET Applications Software Package (SASP) Programmers’ Handbook, Version 2.
  1209. Signatures analysis systems prototype (SASP)
  1210. PAI-1-Stimulated AT2 Cell SASP Promotes Profibrotic Polarization of Alveolar Macrophages
  1211. … serum antibodies to bacterial antigens may be used as markers for the likelihood of response to SASP could have implications regarding the tailoring of SASP …
  1212. Advances in pain management and research presented at the 2015 Scientific Meeting of the Scandinavian Association for the Study of Pain (SASP)
  1213. SASP-A digital signal processor system for speech processing applications
  1214. Poster-abstracts from SASP–The Scandinavian Association for the Study of Pain scientific meeting, Oslo, Norway, April 7–9, 2014
  1215. The salivary gland salivation stimulating peptide from Locusta migratoria (Lom-SG-SASP) is not a neuropeptide
  1216. Poor attendance at the SASP annual meeting
  1217. … OF SOLUBLE TAU AGGREGATES IN BRAIN MICROVASCULAR ENDOTHELIAL CELLS PROMOTES CELLULAR SENESCENCE/SASP AND BLOCKS ENOS …
  1218. Senescence-Associated Secretory Pheno-type (SASP)
  1219. Provisional programme for SASP congress
  1220. THE MANIPULATIVE THERAPISTS’GROUP OF THE SASP
  1221. Algorithms for arithmetic operation in a systolic array of single-bit processor (SASP)
  1222. SASP Erwin Schrödinger Gold Medal 2010
  1223. Lipid metabolism is involved in mitotic slippage-induced SASP upon treatment with anti-mitotic drugs
  1224. The role of SASP in tumor microenvironment.
  1225. Effection of Tripterygium Wilfordii Unions SASP Moves to Rheumatoid Arthritis [J]
  1226. Prospects for (p, pi) physics in the Delta region using the SASP spectrometer
  1227. Scientific presentations at the 2017 annual meeting of the Scandinavian Association for the Study of Pain (SASP)
  1228. Assessing Functional Roles of the Senescence-Associated Secretory Phenotype (SASP)
  1229. Report of first AGM of obstetric group of SASP
  1230. Conceptual design study Science and Application Space Platform SASP. Volume 1: Executive summary
  1231. Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP)(IV): Pharmacokinetics of SASP in the rat following consecutive oral doses.
  1232. SASP/” target=”_blank” rel=”noopener” data-saferedirecturl=”https://www.google.com/url?q=https://transhumanist-party.org/tag/SASP/&source=gmail&ust=1579109268616000&usg=AFQjCNHXsxzxNxwQBGqCzklmOCoFKpYYsg”>Browsed by Tag: SASP
  1233. Treating 150 Cases with Active Ankylosing Spondylitis with Chinese Peashrub Root Powder Capsule combined with SASP
  1234. TOE MANIPULATIVE THERAPISTS’GROUP OF THE SASP
  1235. … of long term radionuclide data for lead-210 and beryllium-7 collected at Murdoch University for the Surface Air Sampling Program (SASP) of the Environmental …
  1236. Human SLE bone marrow mesenchymal stem cells (BMSCs) have a senescence-associated secretory phenotype (SASP) mediated by a MAVS-IFNβ …
  1237. Secondary amine selective Petasis (SASP) bioconjugation
  1238. The senescence-associated secretory phenotype (SASP) from mesenchymal stromal cells impairs growth of immortalized prostate cells but has no effect on …
  1239. Convergent validity of the Richmond Reversal Rating in relation to visual-spatial perception as measured by the SASP
  1240. In Search of Nutritional Anti-Aging Targets: TOR Inhibitors, SASP Modulators And BCL-2 Family Suppressors
  1241. Non-overlapping roles of the RP and p19Arf pathways in protecting oncogenic induced HCC and their roles to modulate SASP
  1242. XXth Symposium on Atomic, Cluster and Surface Physics 2016 (SASP 2016)
  1243. Hep:: HepNames:: Institutions:: Conferences:: Jobs:: Experiments:: Journals:: Help Home> Conferences> DASS/SASP (Dual Arm Spectrometer System …
  1244. 14 ANALYSIS OF SASP REFERENCES: INSIGHTS FOR EFFECTIVE CONTINUING MEDICAL EDUCATION FOR UROLOGISTS
  1245. Correction to: Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP)
  1246. Brief Overview of the ECJ Judgement in the Case of Olympique Lyonais SASP v. Olivier Bernard and Newcastle United Football Club
  1247. The Senescence-Associated Secretory Phenotype (SASP) and Redox-Dependent Invasion of Metastatic Cancer Cells
  1248. PO-112 The senescence associated secretory phenotype (SASP)-factor ccl2 fosters vascular dysfunction and endothelial cell loss in radiation-induced lung disease
  1249. Efficacy of artemisinin and SASP on chicken coccidiosis induced by Eimeria tenella.
  1250. AISA can control the inflammatory facet of SASP
  1251. Momentum Calibration for the SASP Spectrometer
  1252. … Article Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP)
  1253. Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase
  1254. SASP. Contributions to the 13. Symposium on atomic and surface physics and related topics
  1255. Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP)
  1256. SKYNET Applications Software Package (SASP) Operator’s and User’s Handbook.
  1257. Unmasking senescence: context-dependent effects of SASP in cancer
  1258. VOLUME II-TECHNICAL REPORT PART A SASP SPECIAL EMPHASIS TRADE STUDIES’k
  1259. Sexual Assault Services Program (SASP) and Sexual Offense Services (SOS)
  1260. Review of Best Practices for ICJI Program Areas: Sexual Assault Services Program (SASP) and Sexual Offense Services (SOS)
  1261. Chronic resveratrol treatment inhibits MRC5 fibroblast SASP-related pro-tumoral effects on melanoma cells
  1262. P10 CELL SURFACE INTERLEUKIN-1α, WHICH DRIVES THE SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP), IS TETHERED VIA IL …
  1263. The annual meeting of the Scandinavian Association for the Study of Pain (SASP) 18-20 April 2018− S1
  1264. Science and Applications Space Platform (SASP) End-to-End Data System Study
  1265. … Responses and Protection in Dairy Cows Vaccinated withStaphylococcus aureusSurface Proteins (SASP) andStaphylococcus chromogenes Surface Proteins …
  1266. … /REPERFUSION (I/R) INDUCED INFLAMMAGING BY INHIBITING SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) IN TUBULAR EPITHELIAL …
  1267. SASP-Symposium on atomic, cluster and surface physics’ 94
  1268. The Triumf Second Arm Spectrometer System (SASP)
  1269. Proceedings of the DASS/SASP (Dual Arm Spectrometer System/Second Arm Spectrometer) Workshop, Vancouver, March 17-18, 1986
  1270. The Abstracts of SASP 2001: The Seventh Annual Meeting of the Society of Australasian Social Psychologists
  1271. SASP’86: Symposium on atomic and surface physics
  1272. 1‐Amino‐2‐(Silyloxymethyl) Pyrrolidines (SASP)
  1273. Address at the opening Jubilee Congress of the SASP by the Minister of Health and Welfare
  1274. SASP. Symposium on atomic and surface physics’ 82. Contributions

[HTML] Senolytics: A Translational Bridge Between Cellular Senescence and Organismal Aging

H Thoppil, K Riabowol – Frontiers in Cell and Developmental Biology, 2019
… Huang et al., 1999; Montero et al., 2011). These compounds form one of the first discovered members of the senolytic class of drugs that selectively induce apoptosis in senescent cells. Four years after their initial identification as …
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BIOMARKERS FOR CELLULAR SENESCENCE

M Demaria – US Patent App. 16/492,410, 2020
… 15. The drug conjugate according to claim 12, wherein the cytotoxic agent is a senolytic agent, a radioisotope, a toxin or a toxic peptide. 16 … The cytotoxic agent can be a radioisotope, a toxin, toxic peptide or a senolytic drug …
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[HTML] Potential Role of Cellular Senescence in Asthma

ZN Wang, RN Su, BY Yang, KX Yang, LF Yang, Y Yan… – Frontiers in Cell and …, 2020
… proteases expressed by senescent lung fibroblasts could result in low-level inflammation and fibrosis (Schafer et al., 2017; Álvarez et al., 2017). Clearance of these senescent fibroblasts by senolytic drugs would render the reso.
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The Heterogeneity of Senescent Cells

LITO Salon
… However, there is no single senolytic that has been shown to target all of our senescent cells … One example is Cleara Biotechnologies, whose founder, Dr. Peter De Keizer, has talked about senolytic “cocktails” and the problem …
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Perspectives of the potential implications of polyphenols in influencing the interrelationship between oxi-inflammatory stress, cellular senescence and …

R Sharma, Y Padwad – Trends in Food Science & Technology, 2020
JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. Skip to main content Skip to article …
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[PDF] Special issue on “Molecular genetics of aging and longevity”: a critical time in the field of geroscience

BA Benayoun, RA Veitia
… aging. From the perspective of precision medicine, it will be possible to identify individu- als at higher risk of developing single or multiple morbidi- ties for devising new preventive measures, such as specific senolytic treatments …
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Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson–Gilford progeria syndrome

S Saxena, S Kumar – GeroScience
… 2017). Senescent cells also upregulate the expression of anti-apoptotic proteins BCL-W and BCL-XL, the inhibition of which with siRNA or small molecules ABT-737 or ABT-263 (senolytic drugs) leads to apoptosis (Chang …

[PDF] Establishment of a Temperature-Sensitive Model of Oncogene-Induced Senescence in Angiosarcoma Cells

A Costa, MY Bonner, S Rao, L Gilbert, M Sasaki… – Cancers, 2020
… the nonpermissive temperature. This suggests that the maintenance of the senescent phenotype results in a low level of p38 signaling and that p38 activators might be effective in mediating senolytic therapies. Consistent with …
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Cancer as a disease of old age: changing mutational and microenvironmental landscapes

E Laconi, F Marongiu, J DeGregori – British Journal of Cancer, 2020
Why do we get cancer mostly when we are old? According to current paradigms, the answer is simple: mutations accumulate in our tissues throughout life, and some of these mutations contribute to cancers.

Preadipocyte secretory factors differentially modulate murine macrophage functions during aging which are reversed by the application of phytochemical EGCG

R Kumar, A Sharma, Y Padwad, R Sharma – Biogerontology
… Working on green tea EGCG, we have previously reported its anti- immunosenescence, anti-inflammatory, anti-senescence, senolytic and synbiotic attributes thereby suggesting its multi-faceted potency as an …

[PDF] Novel properties of mature adipocytes in obesity and hyperinsulinemia

Q Li – 2020
Page 1. From the Department of Cell and Molecular Biology Karolinska Institutet, Stockholm, Sweden Novel properties of mature adipocytes in obesity and hyperinsulinemia Qian Li 李 倩 Stockholm 2020 Page 2. Cover picture …

[PDF] Establishment of a Temperature-Sensitive Model of Oncogene-Induced Senescence in Angiosarcoma Cells

A Costa, MY Bonner, S Rao, L Gilbert, M Sasaki… – Cancers, 2020
… the nonpermissive temperature. This suggests that the maintenance of the senescent phenotype results in a low level of p38 signaling and that p38 activators might be effective in mediating senolytic therapies. Consistent with …
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Cancer as a disease of old age: changing mutational and microenvironmental landscapes

E Laconi, F Marongiu, J DeGregori – British Journal of Cancer, 2020
Why do we get cancer mostly when we are old? According to current paradigms, the answer is simple: mutations accumulate in our tissues throughout life, and some of these mutations contribute to cancers. Although …
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Preadipocyte secretory factors differentially modulate murine macrophage functions during aging which are reversed by the application of phytochemical EGCG

R Kumar, A Sharma, Y Padwad, R Sharma – Biogerontology
… Working on green tea EGCG, we have previously reported its anti- immunosenescence, anti-inflammatory, anti-senescence, senolytic and synbiotic attributes thereby suggesting its multi-faceted potency as an …
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[PDF] Novel properties of mature adipocytes in obesity and hyperinsulinemia

Q Li – 2020
Page 1. From the Department of Cell and Molecular Biology Karolinska Institutet, Stockholm, Sweden Novel properties of mature adipocytes in obesity and hyperinsulinemia Qian Li 李 倩 Stockholm 2020 Page 2. Cover picture …

Targeted reduction of senescent cell burden alleviates focal radiotherapy-related bone loss.

A Chandra, AB Lagnado, JN Farr, DG Monroe, S Park… – Journal of bone and mineral …, 2020
… To test if senolytic drugs, which clear senescent cells, alleviate FRT-related bone damage, we administered the senolytic agents, Dasatinib (D), Quercetin (Q), Fisetin (F), and a cocktail of D and Q (D+Q). We found moderate …
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Treating cognitive decline and other neurodegenerative conditions by selectively removing senescent cells from neurological tissue

RM Laberge, J Campisi, M Demaria, N David… – US Patent App. 16/584,638, 2020
… US 20200030323 A1 US20200030323 A1 US 20200030323A1 US 201916584638 A US201916584638 A US 201916584638A US 2020030323 A1 US2020030323 A1 US 2020030323A1 Authority US United States Prior …
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[HTML] Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

T Montero-Melendez, A Nagano, C Chelala, A Filer… – Nature Communications, 2020
Rheumatoid arthritis affects individuals commonly during the most productive years of adulthood. Poor response rates and high costs associated with treatment mandate the search for new therapies. Here we show that targeting a specific …
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[HTML] SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms

CL Xu, B Sang, GZ Liu, JM Li, XD Zhang, LX Liu… – Nucleic Acids Research, 2020
… Moreover, SENEBLOC was shown to be involved in both oncogenic and replicative senes- cence, and from the perspective of senolytic agents we show that the antagonistic actions of rapamycin on senescence are dependent on SENEBLOC ex- pression …
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Repurposing cell penetrating peptides and their novel derivatives and iopromide and iodo-aryl carbonates for treatment of senescence-related diseases and disorders

SS Çinarouglu, E Timucin, GB Akcapinar, U Sezerman… – US Patent App. 16/526,997, 2020
… US2020031873A1 US 20200031873 A1 US20200031873 A1 US 20200031873A1 US 201916526997 A US201916526997 A US 201916526997A US 2020031873 A1 US2020031873 A1 US 2020031873A1 …
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[HTML] Implications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution

A Barbouti, PVS Vasileiou, K Evangelou, KG Vlasis… – Oxidative Medicine and …, 2020

The human thymus is a primary lymphoepithelial organ which supports the production of self-tolerant T cells with competent and regulatory functions. Paradoxically, despite the crucial role that it exerts in T cell-mediated immunity …

[HTML] Taking in consideration the bystander effects of articular senescence

JM Brondello, YM Pers – Annals of Translational Medicine, 2019
… harboring shorten telomeres, by accumulating cycle-dependent kinases inhibitors driving senescence such as p16 Ink4a , p21 Cdkn1A and p57 KIP2 , and finally by producing deleterious catabolic and inflammatory mediators …
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RNA Biology Provides New Therapeutic Targets for Human

LW Harries – Role of RNA Modification in Disease, 2020
… For example, strategies are emerging now which allow selective delivery of senolytic cargoes to senescent cells only using galactosaccharide nanoparticles, which harness the observation that senescent cells harbor …
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The ageing epigenome and its rejuvenation

W Zhang, J Qu, GH Liu, JCI Belmonte – Nature Reviews Molecular Cell Biology, 2020

Ageing is characterized by the functional decline of tissues and organs and the increased risk of ageing-associated disorders. Several ‘rejuvenating’ interventions have been proposed to delay ageing and the onset of …

[PDF] Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy

F Triana-Martínez, MI Loza, E Domínguez – Cells, 2020
… with the promise of future directions on innovative anticancer therapies. Keywords: cellular senescence; stemness; dormancy; quiescence; senolytic 1. Introduction Natural tumor evolution is a complex process, composed of …
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The Heterogeneity of Senescent Cells

NK September
… However, there is no single senolytic that has been shown to target all of our senescent cells … One example is Cleara Biotechnologies, whose founder, Dr. Peter De Keizer, has talked about senolytic “cocktails” and the problem …
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[PDF] Regorafenib Alteration of the BCL-xL/MCL-1 Ratio Provides a Therapeutic Opportunity for BH3-Mimetics in Hepatocellular Carcinoma Models

B Cucarull, A Tutusaus, M Subías, M Stefanovic… – Cancers, 2020
… A-1331852 has been proposed as an agent in cancer therapy [42,43] and, more recently, as a senolytic compound [44]. Interestingly, through a dual mechanism acting on senescent cholangiocytes and activated fibroblasts …
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Cellular Senescence and Tumor Promotion

M Demaria – Geriatric Oncology
… rejuvenation of aged-tissue stem cells (Childs et al. 2017; Soto- Gamez and Demaria 2017). Currently, a limited number of senolytic agents have been identified. 2-DG, a false substrate for the glycolytic metabolism, or bafilomycin A1, a
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[PDF] Henry Ford Health System Scholarly Common s

DE Citrin, PGS Prasanna, AJ Walker, ML Freeman…
… this setting. Although preventing premature senescence has shown promise in preventing RIF, there is increasing interest in agents that can clear prematurely senescent cells from tissues using “senolytic” drugs. Indeed, clearance …
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The role of adipose tissue senescence in obesity-and ageing-related metabolic disorders

Z Liu, KKL Wu, X Jiang, A Xu, KKY Cheng – Clinical Science, 2020

Skip to Main Content …

[PDF] Stress-induced Cellular Senescence Contributes to Chronic Inflammation and Cancer Progression

S KOBASHIGAWA, YM SAKAGUCHI, S MASUNAGA… – Thermal Medicine, 2019
… In addition, a recent study demonstrated the efficacy of senolytic drugs in the selective elimination of senescent cells123); a combined treatment of dasatinib and quercetin (D＋Q) was found to reduce the number of senescent …
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[PDF] Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

MJ Yousefzadeh, J Zhao, C Bukata, EA Wade… – Aging Cell
Abstract Senescent cells accumulate with age in vertebrates and promote aging largely through their senescence‐associated secretory phenotype (SASP). Many types of stress induce senescence, includi…
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Cardiac Glycosides as Senolytic Compounds

N Martin, O Soriani, D Bernard – Trends in Molecular Medicine, 2020
The identification of senolytics, compounds that eliminate senescent cells, is presently a key priority given their therapeutic promise in cancer and aging-associated diseases. Two recent papers by Triana-Martínez et al. and Guerrero et al …
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[HTML] Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype

AJ Barinda, K Ikeda, DB Nugroho, DA Wardhana… – Nature Communications, 2020
Vascular senescence is thought to play a crucial role in an ageing-associated decline of organ functions; however, whether vascular senescence is causally implicated in age-related disease remains unclear. Here we show that …
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[HTML] Urogenital Support

BI Blog, ADN Booster
… Current research has shown that certain plant polyphenols (ie quercetin and fisetin) are strong senolytic agents (molecules that stop senescence), and have exciting potential for reducing and preventing senescence, which …
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[PDF] Transplanting cells from old but not young donors causes physical dysfunction in older recipients

B Wang, Z Liu, VP Chen, L Wang, CL Inman, Y Zhou… – Aging Cell
… Our study potentially begins new avenues of research to discover whether pharmacological interventions, such as senolytic drugs (Tchkonia & Kirkland, 2018) or anti‐inflammatory drugs, can prevent or reverse dysfunction caused …
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[PDF] Preclinical Pharmacological Activities of Epigallocatechin-3-gallate in Signaling Pathways: An Update on Cancer

M Sharifi-Rad, R Pezzani, M Redaelli, M Zorzan… – Molecules, 2020
Page 1. Molecules 2020, 25, 467; doi:10.3390/molecules25030467 www.mdpi.com/ journal/molecules Review Preclinical Pharmacological Activities of Epigallocatechin- 3-gallate in Signaling Pathways: An Update on Cancer

Senolytic compositions and uses thereof

MA Gallop, J Klein, M Quarta – US Patent App. 16/508,477, 2020
UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound data: image/svg+xml; base64, PD94bWwgdmVyc2lvbj0nMS4wJyBlbm…/+ IDwvcmVjdD4KPHBhdGggY2xhc3M9J2…+Cjx0ZXh0IHg9JzIyOS45MjQnIHk9JzE1… PHRzcGFuPkg8L3RzcGFuPjwvdGV4d …
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Impaired Myofibroblast Dedifferentiation Contributes to Non-Resolving Fibrosis in Aging

K Kato, NJ Logsdon, YJ Shin, S Palumbo, A Knox… – American Journal of …, 2020
… One study demonstrated that the senolytic agent, quercetin, restored apoptosis susceptibility in IPF lung myofibroblasts, and inhibited fibrotic responses to lung injury in aged mice (62). Further, the first-in-human pilot study with a senolytic …
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[HTML] Browsed by Tag: Mitochondrial mutations

N Bagalà, S Hill
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[PDF] Cellular senescence contributes to age‐dependent changes in circulating extracellular vesicle cargo and function

FJ Alibhai, F Lim, A Yeganeh, PV DiStefano… – Aging Cell
… Instead, we show that cellular senescence contributes to changes in particle cargo and function. Notably, senolytictreatment of old mice shifted plasma particle cargo and function toward that of a younger phenotype.

Therapy-induced senescence—an induced synthetic lethality in liver cancer?

K Wolter, L Zender – Nature Reviews Gastroenterology & Hepatology, 2020
… cells. Therefore, the directed use of senolytic therapies in human cancers necessitates imaging modalities to non-invasively visualize TIS, thereby enabling image-guidedapplications of senolytic therapies. Full size image. Two …
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Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice.

MB Cavalcante, TD Saccon, ADC Nunes, JL Kirkland… – Aging, 2020
… Collagen deposition in the uterus is related to uterine aging. Senolytic therapies are an option for reducing health complications related to aging. We investigated effects of agingand the senolytic drug combination of dasatinib plus quercetin (D+Q) on uterine fibrosis …
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[HTML] CMV-independent increase in CD27− CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians

C Martin-Ruiz, J Hoffmann, E Shmeleva, T von Zglinicki… – npj Aging and Mechanisms …, 2020
… p < 0.001; **p < 0.01; *p < 0.05 using 1-way ANOVA. Full size image. Senolytic therapy … The gating scheme is depicted in Fig. 2a. Animals, procedures and senolytictreatment. C57BL/6 mice were analyzed at either …
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Dasatinib, a second-generation tyrosine kinase inhibitor, induces melanogenesis via ERK-CREB-MITF-tyrosinase signaling in normal human melanocytes

B Kang, Y Kim, TJ Park, HY Kang – Biochemical and Biophysical Research …, 2020
… allergic asthma. Br. J. Pharmacol., 173 (2016), pp. 1236-1247. Google Scholar. [8] JL Kirkland, T. Tchkonia, Y. Zhu, LJ Niedernhofer, PD RobbinsThe clinical potential of senolytic drugs. J. Am. Geriatr. Soc., 65 (2017), pp. 2297 …
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[PDF] The role of the microbiota in sedentary life style disorders and ageing: Lessons from the animal kingdom

PW O’Toole, PG Shiels – Journal of Internal Medicine, 2020
… Nrf2 regulates over 390 stress defence genes linked to longevity and health span. Moreover, alkyl catechols comprise a group of chemicals that include the senolytic agents fisetin and quercetin, which have proven efficacy in …
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[HTML] Browsed by Tag: cancer

G Stolyarov II, A Grases
… When I am 85, the senolytic DNA machinery will be far from the only addition to my cells … Inflammatory conditions of aging will be a shadow of what they once were, because of senolytic therapies presently under development …
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Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting …

A Yabluchanskiy, S Tarantini, P Balasubramanian… – GeroScience
… Data are expressed as mean ± SEM. Results. WBI induces astrocyte senescence: protective effects of senolytictreatments … 3d, e). WBI impairs eicosanoid gliotransmitter-mediated NVC responses: protective effects of senolytictreatments …
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[HTML] Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age

CM Willis, AM Nicaise, ER Bongarzone, M Givogri… – Scientific Reports, 2020
The aging brain is associated with significant changes in physiology that alter the tissue microenvironment of the central nervous system (CNS). In the aged CNS, increased demyelination has been associated with astrocyte hypertrophy …
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[HTML] TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency

H Chen, H Chen, J Liang, X Gu, J Zhou, C Xie, X Lv… – Experimental & Molecular …, 2020
To study whether TGF-β1/IL-11/MEK/ERK (TIME) signaling mediates senescence-associated pulmonary fibrosis (SAPF) in Bmi-1-deficient (Bmi-1−/−) mice and determines the major downstream mediator of Bmi-1 …

[HTML] Underlying Histopathology Determines Response to Oxidative Stress in Cultured Human Primary Proximal Tubular Epithelial Cells

MA Khan, X Wang, KTK Giuliani, P Nag, A Grivei… – International Journal of …, 2020
Proximal tubular epithelial cells (PTEC) are key players in the progression of kidney diseases. PTEC studies to date have primarily used mouse models and transformed human PTEC lines. However, the translatability of these …
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[HTML] Metabolic Syndrome Support

BI Blog, HIA You
… Current research has shown that certain plant polyphenols (ie quercetin and fisetin) are strong senolytic agents (molecules that stop senescence), and have exciting potential for reducing and preventing senescence, which …
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PDF] Senescent Colon and Breast Cancer Cells Induced by Doxorubicin Exhibit Enhanced Sensitivity to Curcumin, Caffeine, and Thymoquinone

AH El-Far, NHE Darwish, SA Mousa – Integrative Cancer Therapies, 2020
Cellular senescence is a process of physiological growth arrest that can be induced by intrinsic or extrinsic stress signals. Some cancer therapies are associated with senescence of cancer cells wi…
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Targeting defective pulmonary innate immunity–A new therapeutic option?

KBR Belchamber, LE Donnelly – Pharmacology & Therapeutics, 2020
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Targeting the progression of chronic kidney disease

M Ruiz-Ortega, S Rayego-Mateos, S Lamas, A Ortiz… – Nature Reviews Nephrology, 2020
Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well as ageing of the population. Regardless …
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Cellular senescence: from anti-cancer weapon to anti-aging target

L Yuan, PB Alexander, XF Wang – Science China Life Sciences, 2020
Cellular senescence (CS) is a state of stable cell cycle arrest characterized by the production and secretion of inflammatory molecules. Early studies desc.
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[PDF] Targeting Age-Related Pathways in Heart Failure

H Li, MH Hastings, J Rhee, LE Trager, JD Roh… – Circulation Research, 2020
During aging, deterioration in cardiac structure and function leads to increased susceptibility to heart failure. The need for interventions to combat this age-related cardiac decline is becoming i…
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[HTML] Autophagy Reprograms Alveolar Progenitor Cell Metabolism in Response to Lung Injury

X Li, J Wu, X Sun, Q Wu, Y Li, K Li, Q Zhang, Y Li… – Stem Cell Reports, 2020
JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. Skip to main content Skip to article …
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[HTML] A Newly Synthesized Rhamnoside Derivative Alleviates Alzheimer’s Amyloid-β-Induced Oxidative Stress, Mitochondrial Dysfunction, and Cell Senescence through …

Y Li, J Lu, X Cao, H Zhao, L Gao, P Xia, G Pei – Oxidative Medicine and Cellular …, 2020
Oxidative stress-induced mitochondrial dysfunction and cell senescence are considered critical contributors to Alzheimer’s disease (AD), and oxidant/antioxidant imbalance has been a therapeutic target in AD. SIRT3 …
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