PGC 1Α

1. The biology of PGC-1α and its therapeutic potential
2. PGC-1α: a key regulator of energy metabolism
3. PGC-1α-mediated adaptations in skeletal muscle
4. PGC-1α and PGC-1β regulate mitochondrial density in neurons
5. Bioenergetic analysis of peroxisome proliferator-activated receptor γ coactivators 1α and 1β (PGC-1α and PGC-1β) in muscle cells
6. Multiple environmental and genetic factors influence skeletal muscle PGC-1α and PGC-1β gene expression in twins
7. … PGC-1α) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-α and-γ: identification of novel leucine-rich interaction motif within PGC …
8. Role of PGC‐1α signaling in skeletal muscle health and disease
9. Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway
10. PGC-1α: turbocharging mitochondria
11. Impaired PGC-1α function in muscle in Huntington’s disease
12. PGC-1α, a new therapeutic target in Huntington’s disease?
13. PGC-1α in aging and anti-aging interventions
14. PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity
15. Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α): transcriptional coactivator and metabolic regulator
16. PGC-1α supports glutamine metabolism in breast cancer
17. FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway
18. Transcriptional coactivators PGC-1α and PGC-lβ control overlapping programs required for perinatal maturation of the heart
19. Transcriptional control of mitochondrial biogenesis: the central role of PGC-1α
20. … transcription of the peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) gene in skeletal muscle through the PGC-1α autoregulatory loop and …
21. Activation of nuclear receptor coactivator PGC-1α by arginine methylation
22. Regulation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and mitochondrial function by MEF2 and HDAC5
23. Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
24. PGC-1α, mitochondrial dysfunction, and Huntington’s disease
25. Metabolic adaptations through the PGC-1α and SIRT1 pathways
26. A fundamental system of cellular energy homeostasis regulated by PGC-1α
27. PGC-1α regulates the mitochondrial antioxidant defense system in vascular endothelial cells
28. Sirtuin 3, a new target of PGC-1α, plays an important role in the suppression of ROS and mitochondrial biogenesis
29. SUMOylation attenuates the function of PGC-1α
30. A role for the transcriptional coactivator PGC-1α in muscle refueling
31. Development of insulin resistance in mice lacking PGC-1α in adipose tissues
32. The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis
33. Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis
34. Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
35. Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor α (ERRα) ligand
36. PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson’s disease
37. Endothelial PGC-1α mediates vascular dysfunction in diabetes
38. IRF4 is a key thermogenic transcriptional partner of PGC-1α
39. PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy
40. Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway
41. PGC-1α expression decreases in the Alzheimer disease brain as a function of dementia
42. The many roles of PGC-1α in muscle—recent developments
43. The role of PGC-1α in the pathogenesis of neurodegenerative disorders
44. The role of PGC-1α on mitochondrial function and apoptotic susceptibility in muscle
45. Metformin induces PGC‐1α expression and selectively affects hepatic PGC‐1α functions
46. PGC-1α is coupled to HIF-1α-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells
47. Re-evaluating the FOXO1–PGC-1α connection
48. PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice
49. Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR
50. Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1α expression
51. Exercise and adrenaline increase PGC‐1α mRNA expression in rat adipose tissue
52. Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism
53. PGC-1α at the crossroads of type 2 diabetes
54. Decreased mRNA Expression of PGC-1α and PGC-1α-Regulated Factors in the SOD1G93A ALS Mouse Model and in Human Sporadic ALS
55. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
56. Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines
57. The transcriptional coactivator PGC-1α mediates exercise-induced angiogenesis in skeletal muscle
58. PGC-1α and PGC-1β have both similar and distinct effects on myofiber switching toward an oxidative phenotype
59. A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy
60. Regulation of hypoxia-inducible genes by PGC-1α
61. Exercise induces transient transcriptional activation of the PGC‐1α gene in human skeletal muscle
62. Regulation of mitochondrial biogenesis and PGC-1α under cellular stress
63. Suppression of β cell energy metabolism and insulin release by PGC-1α
64. Mutual dependence of Foxo3a and PGC-1α in the induction of oxidative stress genes
65. Isoform-specific increases in murine skeletal muscle peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) mRNA in response to β2-adrenergic …
66. Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging
67. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
68. Mitochondria and PGC-1α in aging and age-associated diseases
69. Transcriptional repression of PGC-1α by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
70. Exercise stimulates PGC-1α transcription in skeletal muscle through activation of the p38 MAPK pathway
71. PPARγ co-activator-1α (PGC-1α) reduces amyloid-β generation through a PPARγ-dependent mechanism
72. PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
73. The truncated splice variants, NT‐PGC‐1α and PGC‐1α4, increase with both endurance and resistance exercise in human skeletal muscle
74. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
75. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1α null mice
76. Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1α
77. PGC-1α regulates a HIF2α-dependent switch in skeletal muscle fiber types
78. PGC-1α mediates exercise-induced skeletal muscle VEGF expression in mice
79. Hypothalamic PGC-1α protects against high-fat diet exposure by regulating ERα
80. Peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial …
81. Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
82. Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle
83. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α: modulation by p38 MAPK
84. An increase in murine skeletal muscle peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) mRNA in response to exercise is mediated by β …
85. GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1α
86. Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1α in rats
87. AMP-activated protein kinase-regulated activation of the PGC-1α promoter in skeletal muscle cells
88. PGC-1α rescues Huntington’s disease proteotoxicity by preventing oxidative stress and promoting TFEB function
89. SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α
90. PGC-1α: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes
91. Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of …
92. Interactions between ROS and AMP kinase activity in the regulation of PGC-1α transcription in skeletal muscle cells
93. Rapid exercise-induced changes in PGC-1α mRNA and protein in human skeletal muscle
94. Separation of the gluconeogenic and mitochondrial functions of PGC-1α through S6 kinase
95. PGC-1α activates CYP7A1 and bile acid biosynthesis
96. PGC-1α deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis
97. Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
98. PGC-1α regulates normal and pathological angiogenesis in the retina
99. PGC-1α controls hepatitis B virus through nutritional signals
100. A functional interaction between RIP140 and PGC-1α regulates the expression of the lipid droplet protein CIDEA
101. Targeting PGC-1α to control energy homeostasis
102. The gene coding for PGC-1α modifies age at onset in Huntington’s Disease
103. Non-CpG methylation of the PGC-1α promoter through DNMT3B controls mitochondrial density
104. Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
105. Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1
106. PGC‐1α activation as a therapeutic approach in mitochondrial disease
107. SCFCdc4 acts antagonistically to the PGC-1α transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis
108. In vivo correction of COX deficiency by activation of the AMPK/PGC-1α axis
109. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex
110. Acute endurance exercise increases the nuclear abundance of PGC-1α in trained human skeletal muscle
111. mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex
112. PGC-1α mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle
113. SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex
114. Mitochondrial biogenesis and peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α) deacetylation by physical activity: intact adipocytokine signaling is …
115. Exercise-induced PGC-1α transcriptional factors in skeletal muscle
116. Nitric oxide and AMPK cooperatively regulate PGC‐1α in skeletal muscle cells
117. PGC-1α, a key modulator of p53, promotes cell survival upon metabolic stress
118. PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
119. Roles of oxidative stress, apoptosis, PGC-1α and mitochondrial biogenesis in cerebral ischemia
120. PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner
121. The importance of PGC-1α in contractile activity-induced mitochondrial adaptations
122. Effects of resveratrol and SIRT1 on PGC-1α activity and mitochondrial biogenesis: a reevaluation
123. PGC-1α buffers ROS-mediated removal of mitochondria during myogenesis
124. PGC-1α is dispensable for exercise-induced mitochondrial biogenesis in skeletal muscle
125. PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription
126. Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1α
127. PGC-1α-mediated branched-chain amino acid metabolism in the skeletal muscle
128. PGC-1α coactivates PDK4 gene expression via the orphan nuclear receptor ERRα: a mechanism for transcriptional control of muscle glucose metabolism
129. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
130. Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
131. PGC-1α-induced improvements in skeletal muscle metabolism and insulin sensitivity
132. Dynamic regulation of PGC‐1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response
133. PGC-1α is not mandatory for exercise-and training-induced adaptive gene responses in mouse skeletal muscle
134. … rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1α gene transcription: an autoregulatory loop controls PGC-1α expression in adipocytes …
135. Modular evolution of PGC-1α in vertebrates
136. PGC-1α and ERRα target gene downregulation is a signature of the failing human heart
137. Thermoregulatory and metabolic defects in Huntington’s disease transgenic mice implicate PGC-1α in Huntington’s disease neurodegeneration
138. Effects of acute bouts of running and swimming exercise on PGC-1α protein expression in rat epitrochlearis and soleus muscle
139. Effects of Wnt signaling on brown adipocyte differentiation and metabolism mediated by PGC-1α
140. Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1α
141. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1α transcription coactivator
142. … activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) deacetylation following endurance …
143. Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease
144. FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
145. Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) …
146. Diammonium Glycyrrhizinate Upregulates PGC-1α and Protects against Aβ1–42-Induced Neurotoxicity
147. PGC-1α induces apoptosis in human epithelial ovarian cancer cells through a PPARγ-dependent pathway
148. Parvalbumin deficiency and GABAergic dysfunction in mice lacking PGC-1α
149. Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1α transcription and mitochondrial biogenesis in muscle cells
150. PPARδ, but not PPARα, activates PGC-1α gene transcription in muscle
151. Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism
152. PGC-1α and exercise in the control of body weight
153. The role of nNOS and PGC-1α in skeletal muscle cells
154. Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk
155. The effects of acute and chronic exercise on PGC‐1α, irisin and browning of subcutaneous adipose tissue in humans
156. Skeletal muscle-specific expression of PGC-1α-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake
157. Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function
158. PGC-1α over-expression promotes recovery from mitochondrial dysfunction and cell injury
159. Nitric oxide regulates mitochondrial oxidative stress protection via the transcriptional coactivator PGC‐1α
160. FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
161. Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals
162. A PGC-1α-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose
163. Exercise increases mitochondrial PGC-1α content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis
164. Partnership of PGC-1α and HNF4α in the regulation of lipoprotein metabolism
165. Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1α
166. PGC-1α is required for exercise-and exercise training-induced UCP1 up-regulation in mouse white adipose tissue
167. Transcriptional coactivator PGC-1α regulates chondrogenesis via association with Sox9
168. Identification and characterization of an alternative promoter of the human PGC-1α gene
169. Novel Small-Molecule PGC-1α Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice
170. The orphan nuclear receptor SHP regulates PGC-1α expression and energy production in brown adipocytes
171. Genome-wide coactivation analysis of PGC-1α identifies BAF60a as a regulator of hepatic lipid metabolism
172. PGC-1α integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle
173. Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1α to exercise training
174. Exercise training attenuates aging-associated mitochondrial dysfunction in rat skeletal muscle: role of PGC-1α
175. PGC-1α regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload
176. Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis
177. Peroxisome proliferator‐activated receptor‐γ co‐activator‐1α (PGC‐1α) gene polymorphisms and their relationship to Type 2 diabetes in Asian Indians
178. PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis
179. Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1α: regulation by SUMOylation and oxidation
180. Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch
181. O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability
182. Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1α
183. Modest PGC-1α overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar …
184. PGC-1α regulation of mitochondrial degeneration in experimental diabetic neuropathy
185. PGC-1α-mediated regulation of gene expression and metabolism: implications for nutrition and exercise prescriptions
186. TRPV1 activation improves exercise endurance and energy metabolism through PGC-1α upregulation in mice
187. Effects of high‐intensity intermittent swimming on PGC‐1α protein expression in rat skeletal muscle
188. Exercise Prevents Maternal High-Fat Diet–Induced Hypermethylation of the PGC-1α Gene and Age-Dependent Metabolic Dysfunction in the Offspring
189. PGC-1α and myokines in the aging muscle–a mini-review
190. PGC-1α at the intersection of bioenergetics regulation and neuron function: from Huntington’s disease to Parkinson’s disease and beyond
191. Rescue of dystrophic skeletal muscle by PGC-1α involves a fast to slow fiber type shift in the mdx mouse
192. Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1α expression in experimental stroke
193. Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the …
194. PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity
195. Alterations in the mitochondrial regulatory pathways constituted by the nuclear co-factors PGC-1α or PGC-1β and mitofusin 2 in skeletal muscle in type 2 …
196. Dissociation of increases in PGC-1α and its regulators from exercise intensity and muscle activation following acute exercise
197. PGC-1α is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis
198. The p38–PGC-1α–irisin–betatrophin axis: Exploring new pathways in insulin resistance
199. PGC-1α: a master gene that is hard to master
200. Identification of a specific molecular repressor of the peroxisome proliferator-activated receptor γ coactivator-1 α (PGC-1α)
201. The transcriptional coactivator PGC-1α is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis
202. Peroxisomal proliferator-activated receptor-γ coactivator-1α (PGC-1α) enhances the thyroid hormone induction of carnitine palmitoyltransferase I (CPT-Iα)
203. PGC-1α plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle
204. Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle
205. The microRNA miR-696 regulates PGC-1α in mouse skeletal muscle in response to physical activity
206. The protein level of PGC-1α, a key metabolic regulator, is controlled by NADH-NQO1
207. Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1α mRNA: a role of β2-adrenergic receptor activation
208. Whole body overexpression of PGC-1α has opposite effects on hepatic and muscle insulin sensitivity
209. Mitochondrial defect and PGC-1α dysfunction in parkin-associated familial Parkinson’s disease
210. Transcriptional coactivator PGC-1α promotes peroxisomal remodeling and biogenesis
211. The p65 subunit of NF-κB binds to PGC-1α, linking inflammation and metabolic disturbances in cardiac cells
212. Localization of the transcriptional coactivator PGC‐1α to GABAergic neurons during maturation of the rat brain
213. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1α …
214. p53 orchestrates the PGC-1α-mediated antioxidant response upon mild redox and metabolic imbalance
215. Neuronal inactivation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) protects mice from diet-induced obesity and leads to …
216. HIF-1α and HIF-2α are critically involved in hypoxia-induced lipid accumulation in hepatocytes through reducing PGC-1α-mediated fatty acid β-oxidation
217. Role of PGC-1α in exercise and fasting-induced adaptations in mouse liver
218. Exercise and PGC-1α-independent synchronization of type I muscle metabolism and vasculature by ERRγ
219. An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle
220. Twist-1 is a PPARδ-inducible, negative-feedback regulator of PGC-1α in brown fat metabolism
221. TNF‐α‐mediated reduction in PGC‐1α may impair skeletal muscle function after cigarette smoke exposure
222. The homeobox protein Prox1 is a negative modulator of ERRα/PGC-1α bioenergetic functions
223. Complex haplotypes of the PGC-1α gene are associated with carbohydrate metabolism and type 2 diabetes
224. Role of PGC-1α in muscle function and aging
225. The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1α
226. Decorin induces mitophagy in breast carcinoma cells via peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and mitostatin
227. Expression of the thermogenic nuclear hormone receptor coactivator PGC-1α is reduced in the adipose tissue of morbidly obese subjects
228. Exercise, PGC-1α, and metabolic adaptation in skeletal muscle
229. RETRACTED: Activation of the PPAR/PGC-1α Pathway Prevents a Bioenergetic Deficit and Effectively Improves a Mitochondrial Myopathy Phenotype
230. Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1α
231. Endurance training increases skeletal muscle LKB1 and PGC-1α protein abundance: effects of time and intensity
232. Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1α) expression in the murine brain
233. Human skeletal muscle fibre type variations correlate with PPARα, PPARδ and PGC‐1α mRNA
234. Alternative splice variant PGC-1α-b is strongly induced by exercise in human skeletal muscle
235. PCAF improves glucose homeostasis by suppressing the gluconeogenic activity of PGC-1α
236. Hypoxia induces PGC-1α expression and mitochondrial biogenesis in the myocardium of TOF patients
237. Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS
238. SIRT5 is under the control of PGC‐1α and AMPK and is involved in regulation of mitochondrial energy metabolism
239. Exercise with low glycogen increases PGC-1α gene expression in human skeletal muscle
240. PGC-1α increases skeletal muscle lactate uptake by increasing the expression of MCT1 but not MCT2 or MCT4
241. Selenoprotein P expression is controlled through interaction of the coactivator PGC‐1α with FoxO1a and hepatocyte nuclear factor 4α transcription factors
242. PGC-1α overexpression results in increased hepatic fatty acid oxidation with reduced triacylglycerol accumulation and secretion
243. Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1α and oxidative phosphorylation
244. PGC‐1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model
245. PGC-1α‘s relationship with skeletal muscle palmitate oxidation is not present with obesity despite maintained PGC-1α and PGC-1β protein
246. Regulatory circuitry of TWEAK-Fn14 system and PGC-1α in skeletal muscle atrophy program
247. Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1α
248. Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1α/LRP130 complex
249. Metformin increases the PGC-1α protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo
250. Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex
251. Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic …
252. T3-mediated expression of PGC-1α via a far upstream located thyroid hormone response element
253. AMPK inhibits myoblast differentiation through a PGC-1α-dependent mechanism
254. PGC-1α is required for AICAR-induced expression of GLUT4 and mitochondrial proteins in mouse skeletal muscle
255. PGC-1α Promotes the Growth of ErbB2/Neu–Induced Mammary Tumors by Regulating Nutrient SupplyImpact of PGC-1α on Cancer Metabolism
256. PGC-1α determines light damage susceptibility of the murine retina
257. The relationship between muscle fiber type-specific PGC-1α content and mitochondrial content varies between rodent models and humans
258. Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction
259. Effects of PGC-1α on TNF-α–induced MCP-1 and VCAM-1 expression and NF-κB activation in human aortic smooth muscle and endothelial cells
260. The PGC-1α-dependent pathway of mitochondrial biogenesis is upregulated in type I endometrial cancer
261. Effect of exercise intensity on isoform-specific expressions of NT-PGC-1α mRNA in mouse skeletal muscle
262. PPARδ agonism activates fatty acid oxidation via PGC-1α but does not increase mitochondrial gene expression and function
263. PGC-1α induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle
264. WldS and PGC-1α regulate mitochondrial transport and oxidation state after axonal injury
265. Loss of PGC-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation
266. Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A
267. … induced increase in gene expression of peroxisome proliferator-activated receptor (PPAR)-γ coactivator 1α (PGC-1α), mitochondrial uncoupling protein 3 …
268. PGC-1α mediates differentiation of mesenchymal stem cells to brown adipose cells
269. Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1α: functional implications in hepatic …
270. Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-α/PGC-1α gene regulatory pathway
271. PGC-1α is required for training-induced prevention of age-associated decline in mitochondrial enzymes in mouse skeletal muscle
272. Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1α/mitofusin-2 regulatory pathway in response to physical activity
273. Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice
274. Structural and biochemical basis for the binding selectivity of peroxisome proliferator-activated receptor γ to PGC-1α
275. PGC-1α/β induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders
276. Endoplasmic reticulum stress links hepatitis C virus RNA replication to wild-type PGC-1α/liver-specific PGC-1α upregulation
277. PGC-1α induction in pulmonary arterial hypertension
278. Selective activation of AMPK‐PGC‐1α or PKB‐TSC2‐mTOR signaling can explain specific adaptive responses to endurance or resistance training‐like electrical …
279. Fetal PGC-1α overexpression programs adult pancreatic β-cell dysfunction
280. PGC-1α and exercise: important partners in combating insulin resistance
281. Regulation of NT-PGC-1α subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1
282. Characterization of novel peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) isoform in human liver
283. The corepressor NCoR1 antagonizes PGC-1α and estrogen-related receptor α in the regulation of skeletal muscle function and oxidative metabolism
284. Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia–reperfusion injury
285. PGC-1α and reactive oxygen species regulate human embryonic stem cell-derived cardiomyocyte function
286. Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing to increased vulnerability in diabetic heart
287. Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease
288. Post-natal induction of PGC-1α protects against severe muscle dystrophy independently of utrophin
289. The Drosophila PGC-1α Homolog spargel Modulates the Physiological Effects of Endurance Exercise
290. Common polymorphisms of the PPAR-γ2 (Pro12Ala) and PGC-1α (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance …
291. Tumor necrosis factor and interleukin 1 decrease RXRα, PPARα, PPARγ, LXRα, and the coactivators SRC-1, PGC-1α, and PGC-1β in liver cells
292. Increased levels of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1α) improve lipid utilisation, insulin signalling and glucose …
293. Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1α and PPARβ/δ gene expression upon rosiglitazone treatment in obese patients with type …
294. Remodeling of calcium handling in skeletal muscle through PGC-1α: impact on force, fatigability, and fiber type
295. Ubiquitin proteasome-dependent degradation of the transcriptional coactivator PGC-1α via the N-terminal pathway
296. NT-PGC-1α protein is sufficient to link β3-adrenergic receptor activation to transcriptional and physiological components of adaptive thermogenesis
297. Identification of novel targets for PGC-1α and histone deacetylase inhibitors in neuroblastoma cells
298. Energy sensing factors PGC-1α and SIRT1 modulate PXR expression and function
299. Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity
300. Parkin’control: regulation of PGC-1α through PARIS in Parkinson’s disease
301. Nicotinamide improves motor deficits and upregulates PGC-1α and BDNF gene expression in a mouse model of Huntington’s disease
302. Mitochondrial biogenesis and PGC-1α deacetylation by chronic treadmill exercise: differential response in cardiac and skeletal muscle
303. Cloning and expression of PPARγ and PGC-1α from the hibernating ground squirrel, Spermophilus tridecemlineatus
304. Cardioprotection by acetylcholine: a novel mechanism via mitochondrial biogenesis and function involving the PGC‐1α pathway
305. … of vascular endothelial growth factor (VEGF) and angiogenesis in muscle by truncated peroxisome proliferator-activated receptor γ coactivator (PGC)-1α
306. Impaired coactivator activity of the Gly482 variant of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) on mitochondrial transcription factor A (Tfam) …
307. Inactivation of Foxo3a and subsequent downregulation of PGC-1α mediate nitric oxide-induced endothelial cell migration
308. Treadmill training increases SIRT-1 and PGC-1α protein levels and AMPK phosphorylation in quadriceps of middle-aged rats in an intensity-dependent …
309. CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis
310. Protection against dexamethasone-induced muscle atrophy is related to modulation by testosterone of FOXO1 and PGC-1α
311. PGC-1α is a key regulator of glucose-induced proliferation and migration in vascular smooth muscle cells
312. Gene expression of PPARγ and PGC-1α in human omental and subcutaneous adipose tissues is related to insulin resistance markers and mediates beneficial …
313. Leptin Administration Favors Muscle Mass Accretion by Decreasing FoxO3a and Increasing PGC-1α in ob/ob Mice
314. Punctum on two different transcription factors regulated by PGC-1α: Nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2
315. PGC-1α promotes nitric oxide antioxidant defenses and inhibits FOXO signaling against cardiac cachexia in mice
316. IL-15 overexpression promotes endurance, oxidative energy metabolism, and muscle PPARδ, SIRT1, PGC-1α, and PGC-1β expression in male mice
317. The astaxanthin-induced improvement in lipid metabolism during exercise is mediated by a PGC-1α increase in skeletal muscle
318. PGC-1α: important for exercise performance?
319. Baicalin increases VEGF expression and angiogenesis by activating the ERRα/PGC-1α pathway
320. MicroRNA-149 inhibits PARP-2 and promotes mitochondrial biogenesis via SIRT-1/PGC-1α network in skeletal muscle
321. Overexpression of PGC-1α increases fatty acid oxidative capacity of human skeletal muscle cells
322. Matched work high-intensity interval and continuous running induce similar increases in PGC-1α mRNA, AMPK, p38, and p53 phosphorylation in human skeletal …
323. Calcineurin signaling and PGC-1α expression are suppressed during muscle atrophy due to diabetes
324. Role of PGC-1α in exercise training-and resveratrol-induced prevention of age-associated inflammation
325. Energizer: PGC-1α keeps the heart going
326. Multiple signaling pathways regulate contractile activity‐mediated PGC‐1α gene expression and activity in skeletal muscle cells
327. Muscle immobilization and remobilization downregulates PGC-1α signaling and the mitochondrial biogenesis pathway
328. Peroxisome proliferator activated receptor α (PPARα) and PPAR gamma coactivator (PGC-1α) induce carnitine palmitoyltransferase IA (CPT-1A) via independent …
329. Dynamic interactions and cooperative functions of PGC-1α and MED1 in TRα-mediated activation of the brown-fat-specific UCP-1 gene
330. Analysis of PGC-1α variants Gly482Ser and Thr612Met concerning their PPARγ2-coactivation function
331. Muscle type‐specific response of PGC‐1α and oxidative enzymes during voluntary wheel running in mouse skeletal muscle
332. Developmental alterations in motor coordination and medium spiny neuron markers in mice lacking PGC-1α
333. PGC-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf
334. Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1α, drives utrophin gene expression at the neuromuscular junction
335. PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons
336. Thioredoxin-interacting protein mediates hepatic lipogenesis and inflammation via PRMT1 and PGC-1α regulation in vitro and in vivo
337. PGC-1α is associated with C2C12 myoblast differentiation
338. Free fatty acids increase PGC-1α expression in isolated rat islets
339. Extranuclear localization of SIRT1 and PGC-1α: an insight into possible roles in diseases associated with mitochondrial dysfunction
340. Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: interference of AMPK/PGC-1α pathway
341. Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC‐1α by PRMT1 and SIRT1
342. Resveratrol exerts pharmacological preconditioning by activating PGC-1α
343. The metabolic regulator PGC-1α directly controls the expression of the hypothalamic neuropeptide oxytocin
344. Acute exercise modulates the Foxo1/PGC‐1α pathway in the liver of diet‐induced obesity rats
345. Regulation of Ca2+ signalling and Ca2+-mediated cell death by the transcriptional coactivator PGC-1α
346. Effects of post-exercise recovery in a cold environment on muscle glycogen, PGC-1α, and downstream transcription factors
347. Inhibition of cardiac PGC‐1α expression abolishes ERβ agonist‐mediated cardioprotection following trauma‐hemorrhage
348. PPARγ/PGC-1α pathway in E-cadherin expression and motility of HepG2 cells
349. Metformin induces microRNA-34a to downregulate the Sirt1/PGC-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress …
350. Impact of PGC-1α on the topology and rate of superoxide production by the mitochondrial electron transport chain
351. PGC-1α serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin II drive catalase down-regulation and vascular hypertrophy
352. Methyl donor deficiency impairs fatty acid oxidation through PGC-1α hypomethylation and decreased ER-α, ERR-α, and HNF-4α in the rat liver
353. Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex
354. Skeletal muscle fibres synthesis in heart failure: role of PGC-1α, calcineurin and GH
355. Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1
356. Cold-induced PGC-1α expression modulates muscle glucose uptake through an insulin receptor/Akt-independent, AMPK-dependent pathway
357. Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway
358. Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice; impact of PGC-1α
359. Defining the action spectrum of potential PGC-1α activators on a mitochondrial and cellular level in vivo
360. p53-PGC-1α pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left …
361. The nuclear bile acid receptor FXR is activated by PGC-1α in a ligand-dependent manner
362. The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading …
363. PGC-1α signaling coordinates susceptibility to metabolic and oxidative injury in the inner retina
364. IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1α
365. Aluminium induced oxidative stress results in decreased mitochondrial biogenesis via modulation of PGC-1α expression
366. PGC-1α Thr394Thr and Gly482Ser variants are significantly associated with T2DM in two North Indian populations: a replicate case-control study
367. Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1/PGC-1α signaling pathway
368. Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): requirement for hepatocyte nuclear factor 4α in gluconeogenesis
369. PGC-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of Alzheimer’s disease
370. Skeletal muscle PGC-1α is required for maintaining an acute LPS-induced TNFα response
371. Caloric restriction ameliorates kidney ischaemia/reperfusion injury through PGC‐1α–eNOS pathway and enhanced autophagy
372. Alpha-lipoic acid upregulates SIRT1-dependent PGC-1α expression and protects mouse brain against focal ischemia
373. The transcriptional coactivators, PGC-1α and β, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance
374. Tumour necrosis factor‐α promotes liver ischaemia‐reperfusion injury through the PGC‐1α/Mfn2 pathway
375. The Gly482Ser missense mutation of the peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) gene associates with reduced insulin sensitivity …
376. Potential roles of PINK1 for increased PGC-1α-mediated mitochondrial fatty acid oxidation and their associations with Alzheimer disease and diabetes
377. Dysfunction of the PGC-1α-mitochondria axis confers adriamycin-induced podocyte injury
378. Upregulation of PGC‐1α expression by A lzheimer’s disease‐associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP
379. Studies of the Gly482Ser polymorphism of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) gene in Danish subjects with the metabolic …
380. PGC-1α transcriptional response and mitochondrial adaptation to acute exercise is maintained in skeletal muscle of sedentary elderly males
381. Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by thyroid hormone: role of the peroxisome proliferator-activated receptor γ coactivator (PGC-1α)
382. FoxO6 and PGC-1α form a regulatory loop in myogenic cells
383. Na, K-ATPase activity in mouse muscle is regulated by AMPK and PGC-1α
384. Mechanism of cardiomyocyte PGC-1α gene regulation by ERRα
385. Identification of ERRα as a specific partner of PGC‐1α for the activation of PDK4 gene expression in muscle
386. Reduced hepatic mitochondrial respiration following acute high-fat diet is prevented by PGC-1α overexpression
387. Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signaling
388. The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway
389. Calcium signalling in the regulation of PGC-1α, PDK4 and HKII mRNA expression
390. High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPARα–FoxO3a–PGC-1α …
391. Maternal protein restriction in rats leads to reduced PGC-1α expression via altered DNA methylation in skeletal muscle
392. The metabolic regulator PGC-1α links hepatitis C virus infection to hepatic insulin resistance
393. Molecular mechanisms underlying the development of endothermy in birds (Gallus gallus): a new role of PGC-1α?
394. Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1α axis
395. The transcriptional coactivator PGC-1α is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling
396. Combinatorial transcription factor regulation of the cyclic AMP-response element on the PGC-1α promoter in white 3T3-L1 and brown HIB-1B preadipocytes
397. PGC-1α and PGC-1β increase CrT expression and creatine uptake in myotubes via ERRα
398. The transcriptional co-activator PGC-1α up regulates apelin in human and mouse adipocytes
399. Transient upregulation of PGC-1α diminishes cardiac ischemia tolerance via upregulation of ANT1
400. Clking on PGC-1α to inhibit gluconeogenesis
401. The effect of continuous and interval exercise on PGC‐1α and PDK4 mRNA in type I and type II fibres of human skeletal muscle
402. PGC-1α inhibits oleic acid induced proliferation and migration of rat vascular smooth muscle cells
403. Regulation of mitochondrial proliferation by PGC-1α induces cellular apoptosis in musculoskeletal malignancies
404. Ethanol Suppresses PGC-1α Expression by Interfering with the cAMP-CREB Pathway in Neuronal Cells
405. PGC‐1α gene expression is down‐regulated by Akt‐mediated phosphorylation and nuclear exclusion of FoxO1 in insulin‐stimulated skeletal muscle
406. Burn plus lipopolysaccharide augments endoplasmic reticulum stress and NLRP3 inflammasome activation and reduces PGC-1α in liver
407. SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1α
408. PGC-1α/β upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations
409. PGC-1α Gly482Ser polymorphism associates with hypertension among Danish whites
410. Suppression of PGC-1α by ethanol: implications of its role in alcohol induced liver injury
411. Fiber type conversion by PGC-1α activates lysosomal and autophagosomal biogenesis in both unaffected and Pompe skeletal muscle
412. Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: role of PGC-1α
413. PGC-1α induces mitochondrial and myokine transcriptional programs and lipid droplet and glycogen accumulation in cultured human skeletal muscle cells
414. Lipoic acid restores age‐associated impairment of brain energy metabolism through the modulation of A kt/JNK signaling and PGC 1α transcriptional pathway
415. Effects of the Peroxisome Proliferator Activated Receptor‐γ Coactivator‐1α (PGC‐1α) Thr394Thr and Gly482Ser Polymorphisms on Rosiglitazone Response in …
416. Transcriptional control of the PGC-1α gene in skeletal muscle in vivo
417. Lithium increases PGC‐1α expression and mitochondrial biogenesis in primary bovine aortic endothelial cells
418. RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1α and modulates brown fat cell metabolism
419. The asymmetric binding of PGC-1α to the ERRα and ERRγ nuclear receptor homodimers involves a similar recognition mechanism
420. Rescue of dystrophic skeletal muscle by PGC-1α involves restored expression of dystrophin-associated protein complex components and satellite cell signaling
421. Cardioprotection against doxorubicin by metallothionein Is associated with preservation of mitochondrial biogenesis involving PGC-1α pathway
422. Maintaining PGC‐1α expression following pressure overload‐induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function
423. Fasting-induced hepatic production of DHEA is regulated by PGC-1α, ERRα, and HNF4α
424. Positive correlation between PPARγ/PGC-1α and γ-GCS in lungs of rats and patients with chronic obstructive pulmonary disease
425. Transcriptional activity of PGC-1α and NT-PGC-1α is differentially regulated by twist-1 in Brown fat metabolism
426. The control of UCP1 is dissociated from that of PGC-1α or of mitochondriogenesis as revealed by a study using β-less mouse brown adipocytes in culture
427. Oxidative status of muscle is determined by p107 regulation of PGC-1α
428. Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α
429. The PGC-1α-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes
430. Icariin promotes expression of PGC‐1α, PPARα, and NRF‐1 during cardiomyocyte differentiation of murine embryonic stem cells in vitro1
431. PGC‐1α encoded by the PPARGC1A gene regulates oxidative energy metabolism in equine skeletal muscle during exercise
432. Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1α signaling
433. Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) stimulates VLDL assembly through activation of cell death-inducing DFFA-like effector B …
434. Roles of transcriptional corepressor RIP140 and coactivator PGC-1α in energy state of chronically infarcted rat hearts and mitochondrial function of cardiomyocytes
435. Elevated FGF21 secretion, PGC-1α and ketogenic enzyme expression are hallmarks of iron–sulfur cluster depletion in human skeletal muscle
436. PGC-1α regulates translocated in liposarcoma activity: role in oxidative stress gene expression
437. Acetylcholine promotes ROS detoxification against hypoxia/reoxygenation-induced oxidative stress through FoxO3a/PGC-1α dependent superoxide dismutase
438. ApoE−/− PGC-1α−/− mice display reduced IL-18 levels and do not develop enhanced atherosclerosis
439. Peroxisome proliferator activated receptor-alpha (PPARα) and PPAR gamma coactivator-1alpha (PGC-1α) regulation of cardiac metabolism in diabetes
440. MicroRNA-23a mediates mitochondrial compromise in estrogen deficiency-induced concentric remodeling via targeting PGC-1α
441. Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1α and AMPK activation
442. Transcriptional network analysis in muscle reveals AP-1 as a partner of PGC-1α in the regulation of the hypoxic gene program
443. Mice lacking the transcriptional coactivator PGC-1α exhibit alterations in inhibitory synaptic transmission in the motor cortex
444. A single nucleotide polymorphism in the coding region of PGC-1α is a male-specific modifier of Huntington disease age-at-onset in a large European cohort
445. Making muscle or mitochondria by selective splicing of PGC-1α
446. Communication between the ERRα homodimer interface and the PGC-1α binding surface via the helix 8–9 loop
447. Co-ingestion of carbohydrate and whey protein isolates enhance PGC-1α mRNA expression: a randomised, single blind, cross over study
448. Multiple binding modes between HNF4α and the LXXLL motifs of PGC-1α lead to full activation
449. ERK and p38 inhibitors attenuate memory deficits and increase CREB phosphorylation and PGC-1α levels in Aβ-injected rats
450. NT-PGC-1α activation attenuates high-fat diet–induced obesity by enhancing brown fat thermogenesis and adipose tissue oxidative metabolism
451. NMDA receptor dependent PGC-1α up-regulation protects the cortical neuron against oxygen-glucose deprivation/reperfusion injury
452. Short term exercise induces PGC-1α, ameliorates inflammation and increases mitochondrial membrane proteins but fails to increase respiratory enzymes in …
453. Gene program-specific regulation of PGC-1α activity
454. PGC-1α increases PDH content but does not change acute PDH regulation in mouse skeletal muscle
455. Energy dysfunction in Huntington’s disease: insights from PGC-1α, AMPK, and CKB
456. Inverse relationship between PGC-1α protein expression and triacylglycerol accumulation in rodent skeletal muscle
457. Acetyl-l-Carnitine Activates the Peroxisome Proliferator-Activated Receptor-γ Coactivators PGC-1α/PGC-1β–Dependent Signaling Cascade of Mitochondrial …
458. PGC-1α Gly482Ser polymorphism is associated with the plasma adiponectin level in type 2 diabetic men
459. The effect of overexpression of PGC-1α on the mtDNA4834 common deletion in a rat cochlear marginal cell senescence model
460. Promoting PGC-1α-driven mitochondrial biogenesis is detrimental in pressure-overloaded mouse hearts
461. Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus
462. Peroxisomal proliferator activated receptor gamma coactivator (PGC-1α) stimulates carnitine palmitoyltransferase I (CPT-Iα) through the first intron
463. The nuclear receptor coactivator PGC-1α exhibits modes of interaction with the estrogen receptor distinct from those of SRC-1
464. Activating mitochondrial regulator PGC-1α expression by astrocytic NGF is a therapeutic strategy for Huntington’s disease
465. PGC-1α is induced by parathyroid hormone and coactivates Nurr1-mediated promoter activity in osteoblasts
466. Roles of histone deacetylation and AMP kinase in regulation of cardiomyocyte PGC-1α gene expression in hypoxia
467. cAMP-mediated regulation of HNF-4α depends on the level of coactivator PGC-1α
468. Lithium chloride inhibits vascular smooth muscle cell proliferation and migration and alleviates injury-induced neointimal hyperplasia via induction of PGC-1α
469. PGC-1α attenuates neointimal formation via inhibition of vascular smooth muscle cell migration in the injured rat carotid artery
470. The effects of running exercise on oxidative capacity and PGC-1α mRNA levels in the soleus muscle of rats with metabolic syndrome
471. Fine-tuned regulation of the PGC-1α gene transcription by different intracellular signaling pathways
472. … due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) …
473. Glucocorticoid receptor mediated repression of human insulin gene expression is regulated by PGC-1α
474. A PGC-1α-and muscle fibre type-related decrease in markers of mitochondrial oxidative metabolism in skeletal muscle of humans with inherited insulin resistance
475. Dynamic mobilization of PGC-1α mediates mitochondrial biogenesis for the protection of RGC-5 cells by resveratrol during serum deprivation
476. Striated muscle activator of Rho signalling (STARS) is a PGC‐1α/oestrogen‐related receptor‐α target gene and is upregulated in human skeletal muscle after …
477. Population stratification may bias analysis of PGC-1α as a modifier of age at Huntington disease motor onset
478. Differential expression of PGC-1α and metabolic sensors suggest age-dependent induction of mitochondrial biogenesis in Friedreich ataxia fibroblasts
479. Enhanced lipid—but not carbohydrate—supported mitochondrial respiration in skeletal muscle of PGC‐1α overexpressing mice
480. Impaired exercise-induced mitochondrial biogenesis in the obese Zucker rat, despite PGC-1α induction, is due to compromised mitochondrial translation elongation
481. T3-mediated gene expression is independent of PGC-1α
482. Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression …
483. Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity
484. Hyperhomocysteinemia attenuates angiogenesis through reduction of HIF-1α and PGC-1α levels in muscle fibers during hindlimb ischemia
485. Aspirin may promote mitochondrial biogenesis via the production of hydrogen peroxide and the induction of Sirtuin1/PGC-1α genes
486. Coactivator PGC-1α regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes
487. β-Adrenergic stimulation does not activate p38 MAP kinase or induce PGC-1α in skeletal muscle
488. Effects of PPARα/PGC-1α on the myocardial energy metabolism during heart failure in the doxorubicin induced dilated cardiomyopathy in mice
489. Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation injury through AMPK/eNOS/PGC-1α signaling pathway
490. PPARGC1A/PGC-1α, TFEB and enhanced proteostasis in Huntington disease: Defining regulatory linkages between energy production and protein–organelle quality …
491. Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1α in rat muscle
492. CMZ reversed chronic ethanol-induced disturbance of PPAR-α possibly by suppressing oxidative stress and PGC-1α acetylation, and activating the MAPK …
493. PGC-1α mRNA level and oxidative capacity of the plantaris muscle in rats with metabolic syndrome, hypertension, and type 2 diabetes
494. Calcineurin A and CaMKIV transactivate PGC-1α promoter, but differentially regulate cytochrome c promoter in rat skeletal muscle
495. Hepatitis C virus dysregulates glucose homeostasis by a dual mechanism involving induction of PGC1α and dephosphorylation of FoxO1
496. Scavenger receptor CD36 mediates inhibition of cholesterol synthesis via activation of the PPARγ/PGC‐1α pathway and Insig1/2 expression in hepatocytes
497. Sequential signaling cascade of IL-6 and PGC-1α is involved in high glucose-induced podocyte loss and growth arrest
498. PGC-1α mediated muscle aerobic adaptations to exercise, heat and cold exposure
499. PGC-1α coactivates estrogen-related receptor-α to induce the expression of glucokinase
500. RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1α-mediated mitochondrial oxidative phosphorylation and glycolysis
501. PGC-1α integrates glucose metabolism and angiogenesis in multiple myeloma cells by regulating VEGF and GLUT-4
502. The inhibitory effect of dexamethasone on platelet-derived growth factor-induced vascular smooth muscle cell migration through up-regulating PGC-1α expression
503. Threshold levels of hepatocyte nuclear factor 6 (HNF-6) acting in synergy with HNF-4 and PGC-1α are required for time-specific gene expression during liver …
504. Transcriptional regulation by nuclear corepressors and PGC-1α: implications for mitochondrial quality control and insulin sensitivity
505. Evaluation of lovastatin effects on expression of anti-apoptotic Nrf2 and PGC-1α genes in neural stem cells treated with hydrogen peroxide
506. Peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α) enhances engraftment and angiogenesis of mesenchymal stem cells in diabetic hindlimb …
507. Neuropathology of partial PGC-1α deficiency recapitulates features of mitochondrial encephalopathies but not of neurodegenerative diseases
508. Transcriptional co-activator PGC-1α gene is associated with chicken skeletal muscle fiber types
509. Sphingosine 1-phosphate (S1P) promotes mitochondrial biogenesis in Hep G2 cells by activating peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α)
510. Regulation of PGC-1α and PGC-1α-responsive genes with forskolin-induced Schwann cell differentiation
511. Induction of PGC-1α expression can be detected in blood samples of patients with ST-segment elevation acute myocardial infarction
512. PGC-1α gene and physical activity in type 2 diabetes mellitus
513. DNA damage induces down-regulation of PEPCK and G6P gene expression through degradation of PGC-1α
514. … factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1α
515. Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1α
516. Epinephrine and AICAR-induced PGC-1α mRNA expression is intact in skeletal muscle from rats fed a high-fat diet
517. Exercise early in life in rats born small does not normalize reductions in skeletal muscle PGC-1α in adulthood
518. Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals
519. Differential regulation of PGC-1α expression in rat liver and skeletal muscle in response to voluntary running
520. 17β-Estradiol inhibits oleic acid-induced rat VSMC Proliferation and migration by restoring PGC-1α expression
521. Role of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in denervation-induced atrophy in aged muscle: facts and hypotheses
522. The mitochondrial SIRT1–PGC-1α axis in podocyte injury
523. The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells
524. Cdc2-like kinase 2 suppresses hepatic fatty acid oxidation and ketogenesis through disruption of the PGC-1α and MED1 complex
525. Regulation of transcriptional coactivator PGC-1α
526. PGC‐1α‐Induced Mitochondrial Alterations in 3T3 Fibroblast Cells
527. Effects of electroacupuncture on PGC-1α expression in brown adipose tissue
528. Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases
529. Effect of Opuntia humifusa Supplementation and Acute Exercise on Insulin Sensitivity and Associations with PPAR-γ and PGC-1α Protein Expression in Skeletal …
530. PGC-1α: looking behind the sweet treat for porphyria
531. Fasting induces the expression of PGC-1α and ERR isoforms in the outer stripe of the outer medulla (OSOM) of the mouse kidney
532. Myocardial ischaemic and diazoxide preconditioning both increase PGC-1α and reduce mitochondrial damage
533. Up-regulation of the Sirtuin 1 (Sirt1) and peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) genes in white adipose tissue of Id1 protein …
534. PGC-1α expression is increased in leukocytes in experimental acute pancreatitis
535. Control of endothelial function and angiogenesis by PGC-1α relies on ROS control of vascular stability
536. Oxidants and Ca+ 2 induce PGC-1α degradation through calpain
537. Quantitative immuno-electron microscopic analysis of depolarization-induced expression of PGC-1α in cultured rat visual cortical neurons
538. Circadian metabolic regulation through crosstalk between casein kinase 1δ and transcriptional coactivator PGC-1α
539. Expression of Adenine Nucleotide Translocase (ANT) Isoform Genes Is Controlled by PGC‐1α Through Different Transcription Factors
540. Cilostazol promotes mitochondrial biogenesis in human umbilical vein endothelial cells through activating the expression of PGC-1α
541. Dynamic partnership between TFIIH, PGC-1α and SIRT1 is impaired in trichothiodystrophy
542. A novel PGC-1α isoform in brain localizes to mitochondria and associates with PINK1 and VDAC
543. Targeting EP4 by curcumin through cross talks of AMP-dependent kinase alpha and p38 mitogen-activated protein kinase signaling: the role of PGC-1α and Sp1
544. Enhanced short-term improvement of insulin response to a low-caloric diet in obese carriers the Gly482Ser variant of the PGC-1α gene
545. Chronic caloric restriction attenuates a loss of sulfatide content in PGC-1α mouse cortex: a potential lipidomic role of PGC-1α in neurodegeneration
546. The key role of PGC-1α in mitochondrial biogenesis and the proliferation of pulmonary artery vascular smooth muscle cells at an early stage of hypoxic exposure
547. … roles of myostatin and PGC-1α in the increase of skeletal muscle and transformation of fiber type in cold-exposed chicks: Expression of myostatin and PGC-1α in …
548. Combined whole-body vibration, resistance exercise, and sustained vascular occlusion increases PGC-1α and VEGF mRNA abundances
549. Time-dependent effects of systemic lipopolysaccharide injection on regulators of antioxidant defence Nrf2 and PGC-1α in the neonatal rat brain
550. Increased renal methylglyoxal formation with down-regulation of PGC-1α-FBPase pathway in cystathionine γ-lyase knockout mice
551. Altering the redox state of skeletal muscle by glutathione depletion increases the exercise‐activation of PGC‐1α
552. Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver
553. PGC-1α accelerates cytosolic Ca2+ clearance without disturbing Ca2+ homeostasis in cardiac myocytes
554. PGC-1α prevents apoptosis in adipose-derived stem cells by reducing reactive oxygen species production in a diabetic microenvironment
555. Sterol-independent repression of low density lipoprotein receptor promoter by peroxisome proliferator activated receptor γ coactivator-1α (PGC-1α)
556. Enhanced differentiation of three-gene-reprogrammed induced pluripotent stem cells into adipocytes via adenoviral-mediated PGC-1α overexpression
557. Lack of Genetic Associations of PPAR-γ and PGC-1α with Alzheimer’s Disease and Parkinson’s Disease with Dementia
558. A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis
559. Regulatory role of PGC-1α/PPAR signaling in skeletal muscle metabolic recruitment during cold acclimation
560. The effects of PGC-1α on control of microvascular Po2 kinetics following onset of muscle contractions
561. Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) upregulated E-cadherin expression in HepG2 cells
562. PGC-1α regulates hepatic hepcidin expression and iron homeostasis in response to inflammation
563. PPARγ activation attenuates cold-induced upregulation of thyroid status and brown adipose tissue PGC-1α and D2
564. Distinct ligand-dependent and independent modes of thyroid hormone receptor (TR)/PGC-1α interaction
565. Ndrg2 is a PGC-1α/ERRα target gene that controls protein synthesis and expression of contractile-type genes in C2C12 myotubes
566. New insights in the regulation of skeletal muscle PGC-1α by exercise and metabolic diseases
567. The metabolic regulator PGC‐1α links anti‐cancer cytotoxic chemotherapy to reactivation of hepatitis B virus
568. The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet
569. New gene targets of PGC-1α and ERRα co-regulation in C2C12 myotubes
570. Inverse Regulation of the Cytosolic Ca2+ Buffer Parvalbumin and Mitochondrial Volume in Muscle Cells via SIRT1/PGC-1α Axis
571. Adenosine prevents TNFα-induced decrease in endothelial mitochondrial mass via activation of eNOS-PGC-1α regulatory axis
572. Localization and regulation of the N terminal splice variant of PGC-1α in adult skeletal muscle fibers
573. Atorvastatin Attenuates TNF-α–induced Increase of Glucose Oxidation Through PGC-1α Upregulation in Cardiomyocytes
574. The peroxisome proliferator-activated receptor gamma coactivator-1 alpha gene (PGC-1α) is not associated with type 2 diabetes mellitus or body mass index among …
575. Muscling in on PGC-1α for improved quality of life in ALS
576. Epigenetic modulation of PGC-1α activity by GCN5 inhibitors: WO2010007085: Novartis Institutes for BioMedical Research, Inc.
577. High circulating levels of RBP4 and mRNA levels of aP2, PGC‐1α and UCP‐2 predict improvement in insulin sensitivity following pioglitazone treatment of drug‐naïve …
578. Dissociation between PGC-1α and GLUT-4 expression in skeletal muscle of rats fed a high-fat diet
579. Effectiveness of sub-maximal intermittent exercise on muscle glycogen depletion, PGC-1α and PDK-4 gene expression
580. Targeting PGC-1α to overcome the harmful effects of glucocorticoids in porcine neonatal pancreas cell clusters
581. PGC-1α induces dynamic protein interactions on the ERRα gene multi-hormone response element nucleosome in kidney cells
582. Change in PGC-1α expression in rat skeletal muscle after low-intensity prolonged swimming exercise
583. Mitochondrial and sarcoplasmic protein changes in hearts from copper-deficient rats: up-regulation of PGC-1α transcript and protein as a cause for mitochondrial …
584. The effect of SIRT1 protein knock down on PGC-1α acetylation during skeletal muscle contraction
585. Impact of angiotensin II on skeletal muscle metabolism and function in mice: contribution of IGF-1, Sirtuin-1 and PGC-1α
586. Nifedipine increases energy expenditure by increasing PGC-1α expression in skeletal muscle
587. Expression pattern of PGC-1α and Mfn2 in insulin resistance and recovery in rat
588. Impaired ubiquitin‐proteasome‐mediated PGC‐1α protein turnover and induced mitochondrial biogenesis secondary to complex‐I deficiency
589. Photobiomodulation on bax and Bcl-2 proteins and SIRT1/PGC-1α axis mRNA expression levels of aging rat skeletal muscle
590. Downregulation of Pgc‐1α expression by tea leaves and their by‐products
591. Alpha-lipoic acid increases energy expenditure by enhancing AMPK-PGC-1α signalling in the skeletal muscle of aged mice
592. Neuronal activity controls the antagonistic balance between PGC-1α and SMRT in regulating antioxidant defences
593. Improvement of myocardial lipid accumulation and prevention of PGC-1α induction by fenofibrate
594. Association of PGC-1α gene with intramuscular fat content and muscle fiber traits and gene expression in Tibetan pigs.
595. Gene expression of calpain 3 and PGC-1α is correlated with meat tenderness in the longissimus dorsi muscle of Sutai pigs
596. PGC-1α: The Missing Ingredient for Mesenchymal Stem Cell–Mediated Angiogenesis
597. The role of PGC-1α in regulation of skeletal muscle metabolism
598. Identification of a novel human glucagon receptor promoter: Regulation by cAMP and PGC-1α
599. The region of CQQQKPQRRP of PGC-1α interacts with the DNA-binding complex of FXR/RXRα
600. PGC-1α controls the transcription of the SIRT3 gene, an essential component of the thermogenic brown adipocyte phenotype
601. Down‐expression of PGC‐1α partially mediated by JNK/c‐Jun through binding to CRE site during apoptotic procedure in cerebellar granule neurons
602. PPARβ/δ Activation prevents hypertriglyceridemia caused by a high fat diet. Involvement of AMPK and PGC-1α-Lipin1-PPARα pathway
603. Full-length PGC-1α salvages the phenotype of a mouse model of human neuropathy through mitochondrial proliferation
604. PGC‐1α plays a protective role against oxidative stress in skeletal muscle
605. Effect of PGC-1α on proliferation, migration, and transdifferentiation of rat vascular smooth muscle cells induced by high glucose
606. PGC-1α and metabolic control in skeletal and cardiac muscle
607. Interleukin enhancer-binding factor 3 functions as a liver receptor homologue-1 co-activator in synergy with the nuclear receptor co-activators PRMT1 and PGC-1α
608. Construction and characterization of peroxisome proliferator-activated receptor-gamma co-activator 1 alpha (PGC-1α over-expressing cell line derived from …
609. Cloning, expression and polymorphism analyses of PGC-1α gene of Schizothorax prenanti.
610. Suppression of retinal neovascularization by small interfering RNA targeting PGC-1α
611. TNF and IL-1 decrease RXRα, PPARα, PPARγ, LXRα, and the coactivators SRC-1, PGC-1α, and PGC-1β in liver cells
612. The role of PGC-1α in the regulation of skeletal muscle metabolism
613. AMPK-SIRT1-PGC-1α signaling regulates mitochondrial function in human articular chondrocytes
614. PGC‐1α protects dopaminergic neurons in the MPTP mouse model of Parkinson’s disease
615. Effects of Exercise Intensity on PGC-1α, PPAR-γ, and Insulin Resistance in Skeletal Muscle of High Fat Diet-fed Sprague-Dawley Rats
616. Association of PGC-1α gene polymorphism with type 2 diabetes mellitus
617. PGC-1α gene expression and the influence of dietary n-3 HUFAs in grass carp (Ctenopharyngodon idellus).
618. Erratum to “Curcumin inhibits hepatitis B virus via down‐regulation of the metabolic coactivator PGC‐1α”[FEBS Lett. 584 (2010) 2485–2490]
619. Exercise‐induced PGC‐1α mRNA increase is independent on calcineurin activation in skeletal muscle of rats
620. Similar increases of PGC-1α gene expression in the soleus muscle of healthy male rats following high intensity interval and aerobic training
621. Analyzing phosphorylation-dependent regulation of subcellular localization and transcriptional activity of transcriptional coactivator NT-PGC-1α
622. Truncated PGC—1α and angiogenesis in skeletal muscle
623. Comment on Laker et al. Exercise Prevents Maternal High-Fat Diet–Induced Hypermethylation of the PGC-1α Gene and Age-Dependent Metabolic Dysfunction in the …
624. Role of PGC-1α and PGC-1β in inflammatory processes
625. PGC-1α Gly482Ser polymorphism increases the susceptibility to NAFLD in type 2 diabetic patients
626. Response to Comment on Laker et al. Exercise Prevents Maternal High-Fat Diet–Induced Hypermethylation of the PGC-1α Gene and Age-Dependent Metabolic …
627. Regulation of hepatic metabolism through PGC-1α-mediated pathways
628. Effect of aerobic exercise on leptin and PGC-1α gene expression in a unique cohort of morbidly obese Polynesians with type 2 diabetes
629. Association of PGC-1α Gene Polymorphism with Type 2 Diabetes Mellitus.
630. Effect of Resistance Exercise Intensity on the mRNA Expression of PGC-1α Isoforms in Human Skeletal Muscle
631. Correction: Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice
632. AMP‐activated protein kinase‐regulated activation of the PGC‐1α promoter in skeletal muscle cells
633. PGC‐1α regulates both the constitutive and drug‐inducible expression of human CYP2C9
634. Differentiation of PGC-1α gene expression in skeletal muscles of two chicken breeds.
635. Role of coactivator PGC-1α in energy balance: Importance in the production of beef cattle
636. Voluntary wheel running is necessary for hepatic PGC‐1α adenovirus overexpression to increase hepatic mitochondria in LCR rats (LB741)
637. PGC-1α overexpression increases lipid oxidation in myocytes from extremely obese individuals
638. PGC‐1α deletion accelerates angiotensin II induced endothelial dysfunction by increasing mitochondrial oxidative stress and vascular aging
639. Effects of PGC-1α on endothelial function and apoptosis
640. IDENTIFICATION OF HUMAN PGC-1α-b ISOFORMS USING A NOVEL PGC-1α-b SPECIFIC ANTIBODY
641. The role of PGC-1α and PGC-1β in myotube protein synthesis
642. One more trick in the regulation of PGC-1α
643. Effect of high glucose peritoneal dialysis solution on PGC-1α expression and mitochondria related oxidative injury in human peritoneal mesothelial cells
644. Negative regulation of PGC-1α by NF-κB
645. T3-mediated gene expression is independent of PGC-1α
646. P0221 The negative regulatory role of PGC-1α in pathogenesis of hepatocellular carcinoma
647. INVERSE RELATIONSHIP BETWEEN PGC-1α PROTEIN EXPRESSION
648. Roles of PGC-1α/PPARs pathway in regulating insulin sensitivity in mouse skeletal muscle cells under prolonged hypoxia
649. Exercise Induced PGC-1α Transcriptional Factors in
650. PGC-1α pathway as a potential target for cancer treatment.
651. The role of the coactivators PGC-1α and PGC-1β in retina and skeletal muscle
652. Evolutionary and functional variation of PGC‐1α in vertebrates
653. The role of PGC-1α and PGC-1β during inflammatory processes in skeletal muscle
654. The protective role of PGC‐1α in the recovery of muscle disuse atrophy
655. Photoreceptor sensitivity to oxidative stress can by regulated by non-redundant roles of PGC-1α and PGC-1β
656. Effect of kidney-tonifying, spleen-strengthening, and blood stasis removing recipe on the expression ERRα and PGC-1α mRNA in the bone marrow of the femurs in …
657. Effects of acute bouts of running and swimming exercise on PGC-1α
658. The PGC-II Polymorphism of the Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Gene in Korean Subjects with the Metabolic Syndrome
659. Analysis of neuronal transcripts of PGC-1α transgenic mice
660. Phosphodiesterase inhibition increases PGC‐1α in muscle cells (1102.32)
661. Regulation of PGC‐1α expression in skeletal muscle: Comparison of the effects of calcineurin and PKA/cAMP signaling on PGC‐1α transcription
662. PGC-1α over-expression is related to increased cell proliferation and tumorigenesis
663. Transcriptional regulation of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promoter
664. PGC‐1α‐mediated branched‐chain amino acid metabolism in the skeletal muscle (820.1)
665. Fiber type specific PGC‐1α content and its relation to capillarization and mitochondrial content
666. Understanding the function of PGC-1α Isoforms in ß-cell survival and diabetes
667. PGC-1α and PGC-1β have both similar and distinct effects upon myofiber switching towards an oxidative phenotype.
668. Upstream activators of PGC‐1α transcription with acute contractile activity (1164.4)
669. Activation of the Nuclear Receptor Coactivator PGC-1α Mediates an Atheroprotective Effect
670. Mitochondrial function and protein expression profile in skeletal muscle from PGC‐1α null mice
671. PGC‐1α over‐expression rescues dystrophin‐deficient skeletal muscle
672. Mst1 Inhibits PGC-1α via Inhibition of CREB
673. Relationship of PGC-1α Gene Polymorphism With Insulin Resistance Syndrome in Korean Children
674. Calcineurin-mediated Activation of the Human PPARγ Coactivator-1α (PGC-1α) Gene promoter is Influenced by Haplotype
675. A Mechanistic look at the Regulatory Functions of Peroxisome Proliferator-Activated Receptor γ (PPARγ) Coactivator 1α (PGC-1α) and Estrogen Related Receptor …
676. PPARβ/δ is not required by PGC‐1α to enhance skeletal muscle oxidative metabolism (1164.3)
677. PROTEIN EXPRESSON OF MITOCHONDRIAL MRNA TRANSLATION FACTORS IS DRIVEN BY PGC-1α
678. Eating competence is related to PPARβ/δ and PGC‐1α genotypes
679. Neuroprotection from the huntingtin-repressed transcriptional coactivator PGC-1α
680. Whole-Body Overexpression of PGC-1α Has Opposite Effects on Hepatic and Muscle Insulin Sensitivity.
681. Glucocorticoid receptor mediated repression of human insulin gene expression is regulated by PGC-1α
682. Postnatal PGC‐1α over‐expression improves muscle function in a mouse model of Duchenne muscular dystrophy
683. Revisiting the observation of anxiety-like behavior and assessing phenotypic progression in PGC-1α-deficient mice
684. PGC-1α modulates skeletal muscle regeneration by affecting immune response and satellite cell behavior
685. Influence of contractile activity‐induced intracellular signaling on PGC‐1α activity in muscle cells
686. PGC‐1α gene transfer rescues dystrophic muscle from advanced disease progression (884.18)
687. Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1α to exercise training
688. Acute high‐intensity exercise increases the nuclear abundance of PGC‐1α in equine skeletal muscle
689. Intensity, muscle activation, and PGC‐1α expression are dissociated following supramaximal interval exercise
690. The relationship between rs2970847 polymorphism of PGC-1α gene and susceptibility to type 2 diabetes: a systematic review and meta-analysis
691. Regulation of skeletal muscle plasticity by the transcriptional coregulators PGC-1α and NCoR1
692. Postnatal PGC‐1α gene transfer attenuates acute injury in mdx mice
693. Thioredoxin1 Upregulates PGC-1α and NRF1 and Enhances Mitochondrial Functions
694. Involvement of PGC-1α Signaling in Retinal Astrocyte Activation and Ganglion Cell Damage
695. The Protective Role of AMPK/SIRT1/PGC-1α Signalling in Retinal Astrocytes
696. A PGC‐1α: O‐GlcNAc Transferase Complex Regulates Foxo1a Activation in Response to Glucose
697. ERRα rescues histone deacetylation‐mediated down‐regulation of PGC‐1α expression in hypoxia
698. Uncoordinate regulation of PGC-1α and respiratory chain gene expression in the development of heart failure in rats
699. Abstract LB-278: Metabolic regulator PGC-1α promotes angiogenesis and metastasis in nutrient deprivation selected tumor cells.
700. PGC-1α: A Multifunctional Transcriptional Coactivator Involved in Human Metabolic Disorders
701. C07 Localisation of sequence variations in PGC-1α influence their modifying effect in Huntington’s disease
702. Peptide Therapeutics for the Prevention of Cancers and Cardiovascular Diseases: The Special Value of the PGC-1α Pathway
703. A new SNP of PGC-1α gene associated with abdominal fat in chickens.
704. The effects of PGC‐1α on control of microvascular PO2 kinetics following onset of muscle contractions
705. Suppression of calcineurin signaling reduces PGC‐1α expression in a chronic model of muscle atrophy
706. Conditional knock‐down of the transcriptional coactivator PGC‐1α in mice using Cre‐LoxP induced RNA interference
707. PGC‐1α is required for exercise‐induced mitochondrial biogenesis, but not fiber type transformation, in skeletal muscle
708. Possible control of mitochondrial populations by PGC-1α in the 13-lined ground squirrel retina
709. PEROXYSOME PROLIFERATOR-ACTIVATED RECEPTORS AND THEIR COACTIVATOR—PGC-1α—IN PHYSIOLOGY AND PATHOLOGY OF MYOCARDIUM
710. PGC− 1α Methylation: Molecular Links between Fat Metabolism, Mitochondrial Regulation and Parkinson’s Disease (P05. 060)
711. Glucocorticoids attenuate calcineurin signaling and PGC‐1α expression in muscle during diabetes and kidney disease
712. The molecular dissection of the regulation of PGC-1α and the genome-wide activity of its transcriptional network in skeletal muscle cells
713. PGC-1α and IGFBP-5 expression in skeletal muscle of HF patients
714. Neuronal activity controls the antagonistic between PGC-1α and SMRT in regulating antioxidant defences
715. Combined Effect of Flow‐Mediated Shear Stress and Resveratrol on Sirt1/PGC‐1α Pathway in Vascular Endothelial Cells.
716. Regulation of the metabolic coactivator PGC-1α by p160 myb binding protein and by the anaphase promoting complex
717. Effect of PGC-1α on TNF-α-Induced MCP-1 and VCAM-1 Expression and NF-κB Activation in Human Aortic Smooth Muscle and Endothelial Cells
718. The endothelial function under various blood glucose levels and the protective effect of PGC-1α on macrovasculature in patients with diabetes mellitus
719. ERRα Agonists Regulate PGC-1α/ERRα Pathways in Mouse Myotubes Resulting in Enhanced Oxygen Consumption Rates.
720. Exercise during pregnancy attenuates prenatal high‐fat diet‐induced hypermethylation of Pgc‐1α in skeletal muscle
721. Estrogen‐Related Receptor α (ERRα) represses PGC‐1α‐activated PEPCK gene transcription
722. Overexpression of PGC-1α in rat cardiomyocytes protects against nucleoside reverse transcriptase inhibitor (NRTI)-induced mitochondrial toxicity.
723. Intense Physiological Light Upregulates VEGF and Promotes Choroidal Neovascularization via PGC-1α/ERR-α Pathway
724. GW25-e0854 Atorvastatin Attenuates TNF-α-induced Increase of Glucose Oxidation Through PGC-1α Upregulation in cardiomyocytes
725. Errα and Gabpa/b specify PGC-1α-dependent OXPHOS gene expression that is altered in diabetic muscle
726. Protective Effect of Photoreceptor Outer Segments Phagocytosis for Retinal Pigment Epithelial Cells by PGC-1α/SIRT1
727. PGC‐1α transfection restores early mitochondrial functional abnormalities in mdx skeletal muscle
728. Reduced PGC-1α expression is associated with reduced respiratory capacity and substrate switching in unloaded rat heart
729. Endurance exercise training protects skeletal muscle against doxorubicin‐induced damage via PGC‐1α‐mediated adaptations
730. Identification of putative gene targets of PGC-1α in the brain: Insights into inhibitory neuron maturation, physiology, and behavior
731. The endothelial function under various blood glucose levels and the protective effect of PGC-1α on macrovasculature in patients with diabetes mellitus
732. PGC-1α synergizes ERRα to regulate transcription of mouse SHP in human hepatoma cells
733. Mechanisms activating PGC-1α and consequential transcriptional mechanisms following exercise: A mini
734. Effects of dietary flavonoids added to pharmacological antihypertensive therapy on PPARγ and PGC-1α gene expression.
735. Erratum to ”Overexpression of PGC-1𝛼 Increases Fatty Acid Oxidative Capacity of Human Skeletal Muscle Cells”
736. Amplification of PRDM16, BMP7, PPARα, COX II and PGC-1α Genes Tupaia belangeri
737. Changes of PGC-1α and SIRT1 expression in hippocampus of type 2 diabetes mellitus rats and its significance
738. Transcriptional peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1α) regulates transformation of muscle fiber type in Schizothorax prenanti
739. Maternal low protein diet induces muscle mitochondrial respiration impairment, catch‐up growth and PGC‐1α expression (271.6)
740. Investigating the Epigenetic Regulation of the BDNF, PGC-1α, Myogenin and MHC-IIb Genes
741. Identification of cofactor network, including SIRT1 and SRC-3, which converges on energy expenditure through PGC-1α
742. Redox imbalance activates PGC-1α-mediated mitochondrial antioxidant response during metabolic stress
743. PGC-1α Mediates Anti-Remodeling Impact of cGMP-PDE5 Inhibitor in Failing Hearts
744. Reduced Hepatic Mitochondrial Respiration following acute High-fat Diet is Prevented by PGC-1α Overexpression 2
745. Increased PDK4 expression via PGC‐1α/ERRα–dependent mechanism in mouse skeletal muscle after high fat feeding
746. Remodeling of calcium handling in skeletal muscle through the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α): Impact on force, fatigability …
747. Cardiomyocyte Hypertrophy Induces O-linked-β-N-acetylglucosamine Modification of PGC-1α and Augments its Transcriptional Activity
748. FGF21 deficiency exacerbates chronic alcohol induced fatty liver disease via a p38MAPK and PGC‐1α mediated pathway (653.13)
749. Protective effects of liraglutide on main artery and expression of PGC-1α of liver in rats fed with promoting atherosclerosis diet.
750. Partnership of HNF4α with the transcriptional coactivator PGC-1α in the regulation of hepatic glucose and lipid homeostasis
751. Mitofusin 2 Gene Therapy Increases PGC-1α Expression in Pulmonary Artery Smooth Muscle Cells but Does Not Alter Mitochondrial Oxygen Consumption
752. Quercetin can increase mRNA expression of PGC-1α and SIRT1, and mtDNA and cytochrome c in both skeletal muscle and brain.
753. Adenosine prevents TNFα‐induced decrease in endothelial mitochondrial mass via activation of eNOS‐PGC‐1α regulatory axis (664.5)
754. Omija Fruit Extract Improves Endurance and Energy Metabolism by Upregulating PGC-1α Expression in the Skeletal Muscle of Exercised Rats
755. Opuntia humifusa Supplementation Reduces Fat Weight by Increasing PPAR-γ and PGC-1α Protein Expression in the Skeletal Muscle of Rats
756. Mechanisms activating PGC-1α and consequential transcriptional mechanisms following exercise: A mini review (Early View)
757. Effects of pretreatment with different doses of curcumin on expression of p-CREB and PGC-1α in hippocampus after global cerebral ischemia-reperfusion injury in rats
758. A comparison of PGC-1α mRNA and protein expression in response to one week endurance training on alternate days or consecutive four days
759. Co-ingestion of carbohydrate and whey protein isolates enhance PGC-1α mRNA expression: a randomised, single blind, cross over study
760. CITED2 links hormonal signaling to PGC-1α acetylation in regulation of gluconeogenesis
761. HIF‐1 independent COX‐2 and PGC‐1α pathways maintain brain angiogenic adptational change in aging mouse brain during chronic hypoxia
762. … intensity-dependent regulation of mitochondrial respiration in human skeletal muscle: an effect modulated by the transcription factors PGC-1α, p53 and PHF20
763. Mouse NTCP is directly transactivated via a conserved HNF-4α element in the proximal promoter region, with further co-activation by PGC-1α
764. … ) inhibits chondrocyte catabolic response to pro-inflammatory cytokines and up-regulates anti-oxidant genes via PPARγ coactivator 1α (PGC-1α) and forkhead box O …
765. Lipin 2 is a Liver‐enriched Coactivator of Peroxisome Proliferator‐activated Receptor γ (PPARγ) Coactivator‐1α (PGC‐1α) and Regulates Fatty Acid Metabolism in …
766. Effects of core temperature on exercise-induced mitochondrial biogenesis: Potential role of PGC-1α, AMPK eNOS, SIRT1, and SIRT3
767. The Corepressor NCoR1 Antagonizes PGC-1α and ERRα in the Regulation of Skeletal Muscle Function and Oxidative Metabolism.
768. Suppression of gluconeogenesis in hepatocellular carcinoma by miR-23 directed downregulation of key gluconeogenic enzymes and the transcription factor PGC-1α
769. Exercise-induced PGC-1α Expression does not Lower mtDNA Point Mutation Levels but Downregulates Tyrosine hydroxylase Expression in the Striatum
770. Matched work high-intensity interval and continuous running induce similar 2 increases in PGC-1α mRNA, AMPK, p38 and p53 phosphorylation in human 3 skeletal …
771. Metformin increases the PGC-1α protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo
772. Mitochondrial Function/Dysfunction in Health and Disease: The PGC-1α-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 …
773. PGC-1α Overexpression Results in Increased Hepatic Fatty Acid Oxidation with Reduced Triacylglycerol Accumulation and Secretion 2
774. Impact of Dicer on the Embryonic Stem Cell Epigenome and Androgen Mediated AMPK-PGC-1α Signaling in Prostate Cancer
775. Changes in mRNA Expression of Peroxisome Proliferator-activated Receptor-γ Co-activator 1 (PGC-1α) in Different Tissues of OLETF Rats
776. 3 MANUSCRIPT-2: ERRα as the major effector of gene program regulation by PGC-1α operates in presence and absence of PGC-1α to induce gene …
777. PPARGC1A (PGC-1α) variation associated with DNA damage, diabetes and cardiovascular diseases: the Boston Puerto Rican Health Study
778. Exercise during pregnancy attenuates prenatal high‐fat diet‐induced hypermethylation of the Pgc‐1α gene and protects against age‐induced glucose intolerance in …
779. Genome-wide analysis of the transcriptional network controlled by PGC-1α and ERRα in skeletal muscle from microarray and next generation sequencing data
780. PGC-1α increases skeletal muscle lactate uptake by increasing the expression of MCT1 but not MCT2 or MCT4
781. 4 MANUSCRIPT-3: Inhibition of cyclic nucleotide phosphodiesterase families does not enhance PGC-1α expression in mouse skeletal muscle
782. Correction: Ethanol Suppresses PGC-1α Expression by Interfering with the cAMP-CREB Pathway in Neuronal Cells
783. Hypoadiponectinemia-Induced Ampk-PGC-1α Signaling Impairment and Mitochondrial Biogenesis Dysfunction as a Novel Mechanism Responsible for Enhanced …
784. … Ablation of Bach1 Plays an Important Role in Angiogenesis in A Mouse Hindlimb Ischemia Model through Increases in Expression of PGC-1α and Angiopoietin 1
785. TP 37 Changes in muscle expression of PGC-1α and related signalling molecules in the mdx mouse: Possible impact on adaptive fiber phenotype transition and …
786. Fibroblast Growth Factor-21 (FGF-21) enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons.
787. High Volume Resistance Exercise Enhances PPARδ and PGC-1α Protein Expression, but not Mitochondrial Protein Synthesis in the Obese Zucker Rat.
788. Fibroblast Growth Factor-21 (FGF-21) enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons.
789. Description: PGC-1α (205–216), Proliferator-activated Receptor Coactivator-1 α (205–216)(AA: Ac-Arg-Pro-Cys-Ser-Glu-Leu-Leu-Lys-Tyr-Leu-Thr-Thr-NH2)(MW …
790. An acute bout of high-intensity interval training increases the nuclear abundance 1 of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle 2 3 …
791. Correction: Adenosine Prevents TNFα-Induced Decrease in Endothelial Mitochondrial Mass via Activation of eNOS-PGC-1α Regulatory Axis
792. The association between PGC-1α and Alzheimer’s disease
793. PGC-1α, glucose metabolism and type 2 diabetes mellitus
794. PGC-1α as a pivotal factor in lipid and metabolic regulation
795. PGC− 1α promoter methylation in Parkinson’s disease
796. The hitchhiker’s guide to PGC-1α isoform structure and biological functions
797. The metabolic modulator PGC-1α in cancer
798. PPARγ and PGC-1α as therapeutic targets in Parkinson’s
799. Metabolic roles of PGC-1α and its implications for type 2 diabetes
800. The role of PGC-1α in the development of insulin resistance in skeletal muscle-revisited
801. The role of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) in kidney disease
802. Suppression of PGC-1α is critical for reprogramming oxidative metabolism in renal cell carcinoma
803. PGC-1α and exercise intensity dependent adaptations in mouse skeletal muscle
804. Melatonin prevents D rp1‐mediated mitochondrial fission in diabetic hearts through SIRT 1‐PGC 1α pathway
805. Role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle
806. Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise
807. PGC-1α modulates denervation-induced mitophagy in skeletal muscle
808. Role of PGC-1α in vascular regulation: implications for atherosclerosis
809. A map of the PGC-1α-and NT-PGC-1α-regulated transcriptional network in brown adipose tissue
810. Selective chemical inhibition of PGC-1α gluconeogenic activity ameliorates type 2 diabetes
811. Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 …
812. Adult conditional knockout of PGC-1α leads to loss of dopamine neurons
813. Metabolomic analysis of the skeletal muscle of mice overexpressing PGC-1α
814. Effect of exercise training on skeletal muscle SIRT1 and PGC-1α expression levels in rats of different age
815. PGC‐1α, a potential therapeutic target against kidney aging
816. Sirtuin 1 activation enhances the PGC-1α/mitochondrial antioxidant system pathway in status epilepticus
817. Regulation of mitochondrial biogenesis as a way for active longevity: interaction between the Nrf2 and PGC-1α signaling pathways
818. PGC-1α promotes breast cancer metastasis and confers bioenergetic flexibility against metabolic drugs
819. PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein
820. PGC-1α sparks the fire of neuroprotection against neurodegenerative disorders
821. Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function
822. PGC-1α induces human RPE oxidative metabolism and antioxidant capacity
823. Impact of β-adrenergic signaling in PGC-1α-mediated adaptations in mouse skeletal muscle
824. PGC‐1α deficiency causes spontaneous kidney inflammation and increases the severity of nephrotoxic AKI
825. The inflammatory cytokine TWEAK decreases PGC-1α expression and mitochondrial function in acute kidney injury
826. MYC/PGC-1α balance determines the metabolic phenotype and plasticity of pancreatic cancer stem cells
827. Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α
828. PGC-1α protects from notch-induced kidney fibrosis development
829. EglN2 associates with the NRF 1‐PGC 1α complex and controls mitochondrial function in breast cancer
830. KDM3A senses oxygen availability to regulate PGC-1α-mediated mitochondrial biogenesis
831. Resveratrol regulates microglia M1/M2 polarization via PGC-1α in conditions of neuroinflammatory injury
832. Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
833. Posttranslational regulation of PGC‐1α and its implication in cancer metabolism
834. Coordination of mitochondrial biogenesis by PGC-1α in human skeletal muscle: A re-evaluation
835. Resveratrol alleviates diabetic cardiomyopathy in rats by improving mitochondrial function through PGC-1α deacetylation
836. ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1α/PPAR-α signaling
837. Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α‘
838. Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α
839. Exercise induces TFEB expression and activity in skeletal muscle in a PGC-1α-dependent manner
840. PGC-1α dictates endothelial function through regulation of eNOS expression
841. The role of alterations in mitochondrial dynamics and PGC‐1α over‐expression in fast muscle atrophy following hindlimb unloading
842. Anti-fatigue effect of anwulignan via the NRF2 and PGC-1α signaling pathway in mice
843. Protective role of PGC-1α in diabetic nephropathy is associated with the inhibition of ROS through mitochondrial dynamic remodeling
844. Mitochondrial quality control, promoted by PGC‐1α, is dysregulated by Western diet‐induced obesity and partially restored by moderate physical activity in mice
845. Cisplatin resistance involves a metabolic reprogramming through ROS and PGC-1α in NSCLC which can be overcome by OXPHOS inhibition
846. Role of SIRT1/PGC-1α in mitochondrial oxidative stress in autistic spectrum disorder
847. Role of PGC-1α in sarcopenia: etiology and potential intervention-a mini-review
848. PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis
849. PGC-1α modulates telomere function and DNA damage in protecting against aging-related chronic diseases
850. Regulation of PGC-1α isoform expression in skeletal muscles
851. Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1α/AMPK/Sirt1/PGC-1α/UCP2 pathway in a rat model of neonatal HIE
852. Micro RNA‐455 regulates brown adipogenesis via a novel HIF 1an‐AMPK‐PGC 1α signaling network
853. PGC‐1α promotes exercise‐induced autophagy in mouse skeletal muscle
854. Effect of thyme extract supplementation on lipid peroxidation, antioxidant capacity, PGC-1α content and endurance exercise performance in rats
855. Role of PGC-1α in mitochondrial quality control in neurodegenerative diseases
856. PGC-1α and PGC-1β increase protein synthesis via ERRα in C2C12 myotubes
857. Dietary melatonin attenuates chromium-induced lung injury via activating the Sirt1/PGC-1α/Nrf2 pathway
858. Chia (Salvia hispanica L.) enhances HSP, PGC-1α expressions and improves glucose tolerance in diet-induced obese rats
859. Training intensity modulates changes in PGC‐1α and p53 protein content and mitochondrial respiration, but not markers of mitochondrial content in human skeletal …
860. Mitochondrial dysfunction in Huntington’s disease; interplay between HSF1, p53 and PGC-1α transcription factors
861. The role of PGC-1α/UCP2 signaling in the beneficial effects of physical exercise on the brain
862. Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle
863. The interaction of mitochondrial biogenesis and fission/fusion mediated by PGC-1α regulates rotenone-induced dopaminergic neurotoxicity
864. Chlorpyrifos activates cell pyroptosis and increases susceptibility on oxidative stress‐induced toxicity by miR‐181/SIRT1/PGC‐1α/Nrf2 signaling pathway in human …
865. Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα
866. PGC-1α-mediated changes in phospholipid profiles of exercise-trained skeletal muscle
867. Salidroside stimulates the Sirt1/PGC-1α axis and ameliorates diabetic nephropathy in mice
868. Exercise training protects against aging-induced mitochondrial fragmentation in mouse skeletal muscle in a PGC-1α dependent manner
869. PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity
870. Deposition of 5-methylcytosine on enhancer RNAs enables the coactivator function of PGC-1α
871. MPC1 is essential for PGC-1α-induced mitochondrial respiration and biogenesis
872. Pro-renin receptor suppresses mitochondrial biogenesis and function via AMPK/SIRT-1/PGC-1α pathway in diabetic kidney
873. Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1–PGC-1α axis
874. SIRT3 protects cells from hypoxia via PGC-1α-and MnSOD-dependent pathways
875. PGC-1α overexpression via local transfection attenuates mitophagy pathway in muscle disuse atrophy
876. Epigenetic modifications of the PGC-1α promoter during exercise induced expression in mice
877. FTO is required for myogenesis by positively regulating mTOR-PGC-1α pathway-mediated mitochondria biogenesis
878. Effect of 12-weeks high-intensity interval training on SIRT1, PGC-1α and ERRα protein expression in aged rats
879. The role of TLR4 on PGC-1α-mediated oxidative stress in tubular cell in diabetic kidney disease
880. Isoform‐Specific SCFFbw7 Ubiquitination Mediates Differential Regulation of PGC‐1α
881. SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during …
882. Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons
883. Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway
884. PGC‐1α overexpression by in vivo transfection attenuates mitochondrial deterioration of skeletal muscle caused by immobilization
885. SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis
886. Overexpression of PGC-1α influences mitochondrial signal transduction of dopaminergic neurons
887. AMPK maintains energy homeostasis and survival in cancer cells via regulating p38/PGC-1α-mediated mitochondrial biogenesis
888. PGC-1α controls skeletal stem cell fate and bone-fat balance in osteoporosis and skeletal aging by inducing TAZ
889. Exercise prevents cardiac injury and improves mitochondrial biogenesis in advanced diabetic cardiomyopathy with PGC-1α and Akt activation
890. C1q/TNF-related protein-9 ameliorates Ox-LDL-induced endothelial dysfunction via PGC-1α/AMPK-mediated antioxidant enzyme induction
891. Fenofibrate inhibits atrial metabolic remodelling in atrial fibrillation through PPAR‐α/sirtuin 1/PGC‐1α pathway
892. Effects of exercise in a cold environment on transcriptional control of PGC-1α
893. Cerebellar transcriptional alterations with Purkinje cell dysfunction and loss in mice lacking PGC-1α
894. Calycosin-7-O-β-D-glucoside Attenuates OGD/R-Induced Damage by Preventing Oxidative Stress and Neuronal Apoptosis via the SIRT1/FOXO1/PGC-1α …
895. Irisin reverses insulin resistance in C2C12 cells via the p38-MAPK-PGC-1α pathway
896. Deciphering the dichotomous effects of PGC-1α on tumorigenesis and metastasis
897. PGC-1α/ERRα-Sirt3 pathway regulates DAergic neuronal death by directly deacetylating SOD2 and ATP synthase β
898. Overexpression of PGC‐1α in aging muscle enhances a subset of young‐like molecular patterns
899. PGC-1α ameliorates kidney fibrosis in mice with diabetic kidney disease through an antioxidative mechanism
900. Role of mitochondria in diabetic peripheral neuropathy: Influencing the NAD+-dependent SIRT1–PGC-1α–TFAM pathway
901. Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosis
902. Anti-inflammatory action of β-hydroxybutyrate via modulation of PGC-1α and FoxO1, mimicking calorie restriction
903. Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism
904. Direct link between metabolic regulation and the heat-shock response through the transcriptional regulator PGC-1α
905. Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway
906. Salvianolic acid B improves mitochondrial function in 3T3-L1 adipocytes through a pathway involving PPARγ coactivator-1α (PGC-1α)
907. The PGC-1α/ERRα axis represses one-carbon metabolism and promotes sensitivity to anti-folate therapy in breast cancer
908. Role of microRNA-130b in placental PGC-1α/TFAM mitochondrial biogenesis pathway
909. PPARβ is essential for maintaining normal levels of PGC-1α and mitochondria and for the increase in muscle mitochondria induced by exercise
910. SIRT1/PGC-1α signaling promotes mitochondrial functional recovery and reduces apoptosis after intracerebral hemorrhage in rats
911. Effect of contractile activity on PGC-1α transcription in young and aged skeletal muscle
912. HDAC4 controls muscle homeostasis through deacetylation of myosin heavy chain, PGC-1α, and Hsc70
913. … oxidative stress and apoptosis in podocytes via Sir2-related enzymes, sirtuins1 (SIRT1)/peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) …
914. PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism
915. Overexpression of PGC-1α increases peroxisomal activity and mitochondrial fatty acid oxidation in human primary myotubes
916. The implication of PGC-1α on fatty acid transport across plasma and mitochondrial membranes in the insulin sensitive tissues
917. Passive and post-exercise cold-water immersion augments PGC-1α and VEGF expression in human skeletal muscle
918. Omega-3 fatty acids-enriched fish oil activates AMPK/PGC-1α signaling and prevents obesity-related skeletal muscle wasting
919. Skeletal muscle-specific PGC-1α overexpression suppresses atherosclerosis in apolipoprotein E-knockout mice
920. Swimming intervention mitigates HFD-induced obesity of rats through PGC-1α-irisin pathway.
921. Dihydromyricetin improves skeletal muscle insulin sensitivity by inducing autophagy via the AMPK-PGC-1α-Sirt3 signaling pathway
922. Cortical PGC-1α-dependent transcripts are reduced in postmortem tissue from patients with schizophrenia
923. PGC-1α attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 in HK-2 Cells
924. Peroxisome Proliferator-Activated Receptor γ and PGC-1α in Cancer: Dual Actions as Tumor Promoter and Suppressor
925. The neuroprotective effect of tetramethylpyrazine against contusive spinal cord injury by activating PGC-1α in rats
926. ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues
927. Attenuated PGC-1α isoforms following endurance exercise with blood flow restriction
928. High-fat diet inhibits PGC-1α suppressive effect on NFκB signaling in hepatocytes
929. Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration
930. The protective effects of salidroside from exhaustive exercise-induced heart injury by enhancing the PGC-1α–NRF1/NRF2 pathway and mitochondrial …
931. Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1/PGC‐1α mediated attenuation of mitochondrial oxidative stress
932. Skeletal muscle-specific overexpression of PGC-1α induces fiber-type conversion through enhanced mitochondrial respiration and fatty acid oxidation in mice …
933. Dihydromyricetin stimulates irisin secretion partially via the PGC-1α pathway
934. Isovitexin-mediated regulation of microglial polarization in lipopolysaccharide-induced neuroinflammation via activation of the CaMKKβ/AMPK-PGC-1α …
935. Metformin‐induced autophagy and irisin improves INS‐1 cell function and survival in high‐glucose environment via AMPK/SIRT1/PGC‐1α signal pathway
936. Sestrin2 silencing exacerbates cerebral ischemia/reperfusion injury by decreasing mitochondrial biogenesis through the AMPK/PGC-1α pathway in rats
937. Lactate administration increases mRNA expression of PGC-1α and UCP3 in mouse skeletal muscle
938. PGC-1α protects RPE cells of the aging retina against oxidative stress-induced degeneration through the regulation of senescence and mitochondrial quality …
939. Baicalin ameliorates hepatic insulin resistance and gluconeogenic activity through inhibition of p38 MAPK/PGC-1α pathway
940. Obesity-associated miR-199a/214 cluster inhibits adipose browning via PRDM16–PGC-1α transcriptional network
941. Epoxyeicosatrienoic acids regulate adipocyte differentiation of mouse 3T3 cells, via PGC-1α activation, which is required for HO-1 expression and increased …
942. Apolipoprotein E regulates mitochondrial function through the PGC-1α-sirtuin 3 pathway
943. Sprint-interval but not continuous exercise increases PGC-1α protein content and p53 phosphorylation in nuclear fractions of human skeletal muscle
944. PGC‐1α affects aging‐related changes in muscle and motor function by modulating specific exercise‐mediated changes in old mice
945. Carbon Monoxide Potentiation of L-Type Ca2+ Channel Activity Increases HIF-1α-Independent VEGF Expression via an AMPKα/SIRT1-Mediated PGC-1α/ERRα …
946. Quercetin ameliorates hypobaric hypoxia-induced memory impairment through mitochondrial and neuron function adaptation via the PGC-1α pathway
947. MiR-485-3p and miR-485-5p suppress breast cancer cell metastasis by inhibiting PGC-1α expression
948. N6‐methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO‐PGC‐1α signalling axis
949. PGC-1α repression and high-fat diet induce age-related macular degeneration-like phenotypes in mice
950. TFEB drives PGC-1α expression in adipocytes to protect against diet-induced metabolic dysfunction
951. Time-dependent changes in increased levels of plasma irisin and muscle PGC-1α and FNDC5 after exercise in mice
952. Time since menopause and skeletal muscle estrogen receptors, PGC-1α, and AMPK
953. Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α
954. The AMPK-PGC-1α signaling axis regulates the astrocyte glutathione system to protect against oxidative and metabolic injury
955. Endoplasmic reticulum stress-induced CHOP inhibits PGC-1α and causes mitochondrial dysfunction in diabetic embryopathy
956. Resveratrol regulates skeletal muscle fibers switching through the AdipoR1-AMPK-PGC-1α pathway
957. PGC‐1α and fasting‐induced PDH regulation in mouse skeletal muscle
958. Scutellarin ameliorates nonalcoholic fatty liver disease through the PPARγ/PGC-1α-Nrf2 pathway
959. Oxidative stress induces loss of pericyte coverage and vascular instability in PGC-1α-deficient mice
960. Pathological remodeling of the myocardium in chronic heart failure: role of PGC-1α
961. BPA-induced DNA hypermethylation of the master mitochondrial gene PGC-1α contributes to cardiomyopathy in male rats
962. Effect of PGC-1α overexpression or silencing on mitochondrial apoptosis of goat luteinized granulosa cells
963. Postinfarction exercise training alleviates cardiac dysfunction and adverse remodeling via mitochondrial biogenesis and SIRT1/PGC‐1α/PI3K/Akt signaling
964. GLP-1 contributes to increases in PGC-1α expression by downregulating miR-23a to reduce apoptosis
965. Activation of FoxO1/PGC-1α prevents mitochondrial dysfunction and ameliorates mesangial cell injury in diabetic rats
966. PGC-1α regulates the cell cycle through ATP and ROS in CH1 cells
967. Astragaloside IV protects against isoproterenol-induced cardiac hypertrophy by regulating NF-κB/PGC-1α signaling mediated energy biosynthesis
968. Glucocorticoids alter CRTC-CREB signaling in muscle cells: impact on PGC-1α expression and atrophy markers
969. Adaptation of skeletal muscles to contractile activity of varying duration and intensity: the role of PGC-1α
970. An emerging role for epigenetic regulation of PGC-1α expression in environmentally stimulated brown adipose thermogenesis
971. Effects of PPARα/PGC-1α on the energy metabolism remodeling and apoptosis in the doxorubicin induced mice cardiomyocytes in vitro
972. Upregulation of skeletal muscle PGC-1α through the elevation of cyclic AMP levels by Cyanidin-3-glucoside enhances exercise performance
973. MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α
974. Skeletal muscle PGC-1α modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice
975. Cerebrolysin Ameliorates Focal Cerebral Ischemia Injury Through Neuroinflammatory Inhibition via CREB/PGC-1α Pathway
976. Dexmedetomidine reduces oxidative stress and provides neuroprotection in a model of traumatic brain injury via the PGC-1α signaling pathway
977. Dihydromyricetin attenuates dexamethasone-induced muscle atrophy by improving mitochondrial function via the PGC-1α pathway
978. Mitochondria in peroxisome-deficient hepatocytes exhibit impaired respiration, depleted DNA, and PGC-1α independent proliferation
979. Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration
980. Suppression of endothelial PGC-1α is associated with hypoxia-induced endothelial dysfunction and provides a new therapeutic target in pulmonary arterial …
981. PGC-1α coordinates mitochondrial respiratory capacity and muscular fatty acid uptake via regulation of VEGF-B
982. Obesity causes PGC‐1α deficiency in the pancreas leading to marked IL‐6 upregulation via NF‐κB in acute pancreatitis
983. PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle
984. Increased FXYD1 and PGC‐1α mRNA after blood flow‐restricted running is related to fibre type‐specific AMPK signalling and oxidative stress in human muscle
985. Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1–40/42 and Phospho-Tau May Abet …
986. Quercetin protects against aluminium induced oxidative stress and promotes mitochondrial biogenesis via activation of the PGC-1α signaling pathway
987. PGC-1α activation: a therapeutic target for type 2 diabetes?
988. Genetic or pharmacological activation of the Drosophila PGC-1α ortholog spargel rescues the disease phenotypes of genetic models of Parkinson’s disease
989. Modulation of apoptosis by sulforaphane is associated with PGC-1α stimulation and decreased oxidative stress in cardiac myoblasts
990. Up‐regulation of PGC‐1α in neurons protects against experimental autoimmune encephalomyelitis
991. A comparative study on the effects of high-fat diet and endurance training on the PGC-1α-FNDC5/irisin pathway in obese and nonobese male C57BL/6 mice
992. Resveratrol prevents ROS-induced apoptosis in high glucose-treated retinal capillary endothelial cells via the activation of AMPK/Sirt1/PGC-1α pathway
993. SIRT1/PGC-1α signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids
994. PGC-1α as a Biomarker of Physical Activity-Protective Effect on Colorectal CancerPGC-1α in the Physical Activity–Protective Effect on CRC
995. A novel danshensu-tetramethylpyrazine conjugate DT-010 provides cardioprotection through the PGC-1α/Nrf2/HO-1 pathway
996. … ameliorates amyloid-β-induced learning and memory impairment, possibly via increasing AMPK activity and up-regulation of the PGC-1α/FNDC5/BDNF pathway
997. Downregulation of PGC-1α prevents the beneficial effect of EET-heme oxygenase-1 on mitochondrial integrity and associated metabolic function in obese …
998. Glycyrrhizic acid prevents diabetic nephropathy by activating AMPK/SIRT1/PGC-1α signaling in db/db mice
999. Exploring the role of PGC‐1α in defining nuclear organisation in skeletal muscle fibres
1000. Telomere dysfunction disturbs macrophage mitochondrial metabolism and the NLRP3 inflammasome through the PGC-1α/TNFAIP3 axis
1001. Grape seed procyanidin B2 protects podocytes from high glucose-induced mitochondrial dysfunction and apoptosis via the AMPK-SIRT1-PGC-1α axis in vitro
1002. Exercise training protects against aging-induced cognitive dysfunction via activation of the hippocampal PGC-1α/FNDC5/BDNF pathway
1003. Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K/AKT-PGC-1α signaling pathway
1004. PGC-1α regulates alanine metabolism in muscle cells
1005. Lentivirus-mediated PGC-1α overexpression protects against traumatic spinal cord injury in rats
1006. Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/-mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of …
1007. Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection
1008. Poly (ADP-ribose) polymerase-1 inhibits mitochondrial respiration by suppressing PGC-1α activity in neurons
1009. Electroacupuncture upregulates SIRT1-dependent PGC-1α expression in SAMP8 mice
1010. Impact of adrenaline and metabolic stress on exercise‐induced intracellular signaling and PGC‐1α mRNA response in human skeletal muscle
1011. Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1α pathway in high-fat-diet-induced rats and insulin resistant …
1012. Pyrroloquinoline Quinone, a Redox-Active o-Quinone, Stimulates Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α Signaling Pathway
1013. PGC-1α controls mitochondrial biogenesis in drug-resistant colorectal cancer cells by regulating endoplasmic reticulum stress
1014. Rapidly elevated levels of PGC-1α-b protein in human skeletal muscle after exercise: exploring regulatory factors in a randomized controlled trial
1015. Curcumin attenuates skeletal muscle mitochondrial impairment in COPD rats: PGC-1α/SIRT3 pathway involved
1016. SIRT1 prevents hyperuricemia via the PGC-1α/PPARγ-ABCG2 pathway
1017. Quercetin improve ischemia/reperfusion‐induced cardiomyocyte apoptosis in vitro and in vivo study via SIRT1/PGC‐1α signaling
1018. Sodium bicarbonate ingestion augments the increase in PGC-1α mRNA expression during recovery from intense interval exercise in human skeletal muscle
1019. Hypoxia-induced PGC-1α regulates mitochondrial function and tumorigenesis of colorectal cancer cells
1020. Muscle PGC-1α modulates satellite cell number and proliferation by remodeling the stem cell niche
1021. Altered expression of PGC-1α and PDX1 and their methylation status are associated with fetal glucose metabolism in gestational diabetes mellitus
1022. Adult expression of PGC-1α and-1β in skeletal muscle is not required for endurance exercise-induced enhancement of exercise capacity
1023. Neuroprotection by quercetin via mitochondrial function adaptation in traumatic brain injury: PGC‐1α pathway as a potential mechanism
1024. Moderate modulation of cardiac PGC-1α expression partially affects age-associated transcriptional remodeling of the heart
1025. Inactivation of EWS reduces PGC-1α protein stability and mitochondrial homeostasis
1026. Interaction of CREB and PGC-1α induces fibronectin type III domain-containing protein 5 expression in C2C12 myotubes
1027. Globular CTRP3 promotes mitochondrial biogenesis in cardiomyocytes through AMPK/PGC-1α pathway
1028. PGC-1α acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy
1029. PPARγ coactivator-1α (PGC-1α) protects neuroblastoma cells against amyloid-beta (Aβ) induced cell death and neuroinflammation via NF-κB pathway
1030. Cisplatin enhances hepatitis B virus replication and PGC-1α expression through endoplasmic reticulum stress
1031. Peroxisome proliferator-activated receptor-γ (PPARγ) agonist is neuroprotective and stimulates PGC-1α expression and CREB phosphorylation in human …
1032. Butyrate promotes slow-twitch myofiber formation and mitochondrial biogenesis in finishing pigs via inducing specific microRNAs and PGC-1α expression
1033. Pharmaceutical Induction of PGC-1α Promotes Retinal Pigment Epithelial Cell Metabolism and Protects against Oxidative Damage
1034. Essential role of the PGC‐1α/PPARβ axis in Ucp3 gene induction
1035. l‐Citrulline Supplementation‐Increased Skeletal Muscle PGC‐1α Expression Is Associated with Exercise Performance and Increased Skeletal Muscle Weight
1036. Muscle-specific overexpression of PGC-1α does not augment metabolic improvements in response to exercise and caloric restriction
1037. Heart specific PGC-1α deletion identifies metabolome of cardiac restricted metabolic heart failure
1038. How epigenetic modifications drive the expression and mediate the action of PGC-1α in the regulation of metabolism
1039. PGC-1α overexpression partially rescues impaired oxidative and contractile pathophysiology following volumetric muscle loss injury
1040. PGC-1α may associated with the anti-obesity effect of taurine on rats induced by arcuate nucleus lesion
1041. Gly482Ser PGC-1α gene polymorphism and exercise-related oxidative stress in amyotrophic lateral sclerosis patients
1042. Hepatic oleate regulates liver stress response partially through PGC-1α during high-carbohydrate feeding
1043. Paracrine cross-talk between skeletal muscle and macrophages in exercise by PGC-1α-controlled BNP
1044. Improved skeletal muscle Ca2+ regulation in vivo following contractions in mice overexpressing PGC-1α
1045. … against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1α …
1046. Mitochondrial aldehyde dehydrogenase obliterates insulin resistance-induced cardiac dysfunction through deacetylation of PGC-1α
1047. Acute upregulation of PGC-1α mRNA correlates with training-induced increases in SDH activity in human skeletal muscle
1048. Super-enhancers define a proliferative PGC-1α-expressing melanoma subgroup sensitive to BET inhibition
1049. CTRP9 induces mitochondrial biogenesis and protects high glucose-induced endothelial oxidative damage via AdipoR1-SIRT1-PGC-1α activation
1050. Resistance exercise with low glycogen increases p53 phosphorylation and PGC-1α mRNA in skeletal muscle
1051. The PGC-1α activator ZLN005 ameliorates ischemia-induced neuronal injury in vitro and in vivo
1052. Astragalus polysaccharide attenuates isoproterenol-induced cardiac hypertrophy by regulating TNF-α/PGC-1α signaling mediated energy biosynthesis
1053. Transcriptional control, but not subcellular location, of PGC-1α is altered following exercise in a hot environment
1054. Regulation of endothelial dynamics by PGC-1α relies on ROS control of VEGF-A signaling
1055. Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2ˉ· production in cancer cells
1056. ZL006 protects spinal cord neurons against ischemia-induced oxidative stress through AMPK-PGC-1α-Sirt3 pathway
1057. The protective effect of FGF21 on diabetes-induced male germ cell apoptosis is associated with up-regulated testicular AKT and AMPK/Sirt1/PGC-1α signaling
1058. Aerobic exercise recovers disuse-induced atrophy through the stimulus of the LRP130/PGC-1α complex in aged rats
1059. The PPARGC1A locus and CNS-specific PGC-1α isoforms are associated with Parkinson’s Disease
1060. Enhancement of glucose metabolism via PGC-1α participates in the cardioprotection of chronic intermittent hypobaric hypoxia
1061. Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the Sirt1/AMPK/PGC-1α pathway
1062. PGC-1α, sirtuins and PARPs in Huntington’s disease and other neurodegenerative conditions: NAD+ to rule them all
1063. Mutual antagonism of PINK1/Parkin and PGC-1α contributes to maintenance of mitochondrial homeostasis in rotenone-induced neurotoxicity
1064. Hepatic stearoyl CoA desaturase 1 deficiency increases glucose uptake in adipose tissue partially through the PGC-1α–FGF21 axis in mice
1065. Carbon monoxide stimulates astrocytic mitochondrial biogenesis via L-type Ca2+ channel-mediated PGC-1α/ERRα activation
1066. Inhibition of miR-23a attenuates doxorubicin-induced mitochondria-dependent cardiomyocyte apoptosis by targeting the PGC-1α/Drp1 pathway
1067. Sodium azide induces mitochondria‑mediated apoptosis in PC12 cells through PGC-1α‑associated signaling pathway
1068. Hepatic Stearoyl-CoA desaturase-1 deficiency-mediated activation of mTORC1-PGC-1α axis regulates ER stress during high-carbohydrate feeding
1069. Postexercise cold water immersion modulates skeletal muscle PGC-1α mRNA expression in immersed and nonimmersed limbs: evidence of systemic regulation
1070. Resveratrol rescues cadmium-induced mitochondrial injury by enhancing transcriptional regulation of PGC-1α and SOD2 via the Sirt3/FoxO3a pathway in TCMK-1 …
1071. The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1α signaling axis mediated anti …
1072. PGC-1α downregulation in steatotic liver enhances ischemia-reperfusion injury and impairs ischemic preconditioning
1073. miR-29b overexpression induces cochlear hair cell apoptosis through the regulation of SIRT1/PGC-1α signaling: Implications for age-related hearing loss …
1074. PGC-1α overexpression protects against aldosterone-induced podocyte depletion: role of mitochondria
1075. MALAT1 up-regulator polydatin protects brain microvascular integrity and ameliorates stroke through C/EBPβ/MALAT1/CREB/PGC-1α/PPARγ pathway
1076. Lixisenatide enhances mitochondrial biogenesis and function through regulating the CREB/PGC-1α pathway
1077. Conjugated linoleic acid (CLA) stimulates mitochondrial biogenesis signaling by the upregulation of PPARγ coactivator 1α (PGC-1α) in C2C12 cells
1078. Resveratrol enhances HBV replication through activating Sirt1-PGC-1α-PPARα pathway
1079. Glia maturation factor dependent inhibition of mitochondrial PGC-1α triggers oxidative stress-mediated apoptosis in N27 rat dopaminergic neuronal cells
1080. PGC-1α over-expression suppresses the skeletal muscle atrophy and myofiber-type composition during hindlimb unloading
1081. Balasubramide derivative 3C modulates microglia activation via CaMKKβ-dependent AMPK/PGC-1α pathway in neuroinflammatory conditions
1082. The effect of acute and chronic sprint‐interval training on LRP130, SIRT3, and PGC‐1α expression in human skeletal muscle
1083. Treatment with celastrol protects against obesity through suppression of galanin-induced fat intake and activation of PGC-1α/GLUT4 axis-mediated glucose …
1084. miR449a/SIRT1/PGC-1α is necessary for mitochondrial biogenesis induced by T-2 toxin
1085. PGC-1α (peroxisome proliferator–activated receptor γ coactivator 1-α) overexpression in coronary artery disease recruits NO and hydrogen peroxide during flow …
1086. Protective effects of PGC-1α against lead-induced oxidative stress and energy metabolism dysfunction in testis Sertoli cells
1087. Regulation of brown and white adipocyte transcriptome by the transcriptional coactivator NT-PGC-1α
1088. Formononetin ameliorates cognitive disorder via PGC-1α pathway in neuroinflammation conditions in high-fat diet-induced mice
1089. Resistin destroys mitochondrial biogenesis by inhibiting the PGC-1α/NRF1/TFAM signaling pathway
1090. Pathophysiological mechanism of bone loss in type 2 diabetes involves inverse regulation of osteoblast function by PGC-1α and skeletal muscle atrogenes: AdipoR1 …
1091. PGC‐1α mediates a rapid, exercise‐induced downregulation of glycogenolysis in rat skeletal muscle
1092. … biogenesis and protects against seizure-induced neuronal cell damage in the hippocampus following status epilepticus by activation of the PGC-1α signaling …
1093. PGC-1α driven mitochondrial biogenesis in stromal cells underpins mitochondrial trafficking to leukemic blasts
1094. αvβ5 integrin/FAK/PGC-1α pathway confers protective effects on retinal pigment epithelium
1095. PGC-1α participates in the protective effect of chronic intermittent hypobaric hypoxia on cardiomyocytes
1096. Effect of MPTP on mRNA expression of PGC-1α in mouse brain
1097. Resveratrol ameliorates contrast induced nephropathy through the activation of SIRT1-PGC-1α-Foxo1 signaling in mice
1098. Aerobic training increases expression levels of SIRT3 and PGC-1α in skeletal muscle of overweight adolescents without change in caloric intake
1099. Oxidative and energetic stresses mediate beta-cell dysfunction induced by PGC-1α
1100. PGC-1α promotes ureagenesis in mouse periportal hepatocytes through SIRT3 and SIRT5 in response to glucagon
1101. Combined speed endurance and endurance exercise amplify the exercise‐induced PGC‐1α and PDK4 mRNA response in trained human muscle
1102. Beneficial effects of PGC-1α in the substantia nigra of a mouse model of MPTP-induced dopaminergic neurotoxicity
1103. Vinegar decreases blood pressure by down-regulating AT1R expression via the AMPK/PGC-1α/PPARγ pathway in spontaneously hypertensive rats
1104. Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1α, p53, and DNA damage. A hypothesis
1105. The methionine transamination pathway controls hepatic glucose metabolism through regulation of the GCN5 acetyltransferase and the PGC-1α …
1106. Constitutive PGC-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis
1107. Exercise training‐induced improvement in skeletal muscle PGC‐1α‐mediated fat metabolism is independent of dietary glycemic index
1108. Mutual exacerbation of PGC-1α deregulation and α-synuclein oligomerization
1109. Exercise duration-matched interval and continuous sprint cycling induce similar increases in AMPK phosphorylation, PGC-1α and VEGF mRNA expression in …
1110. Activating the PGC-1α/TERT pathway by catalpol ameliorates atherosclerosis via modulating ROS production, DNA damage, and telomere function …
1111. … effects of compatibility of Aconiti Lateralis Radix Praeparata and Zingiberis Rhizoma on rats with heart failure by enhancing mitochondrial biogenesis via Sirt1/PGC-1α …
1112. Resistin regulates fatty acid Β oxidation by suppressing expression of peroxisome proliferator activator receptor gamma-coactivator 1α (PGC-1α)
1113. The Gly482Ser polymorphism of the peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is associated with type 2 diabetes in Tunisian population
1114. PGC-1α or FNDC5 Is Involved in Modulating the Effects of Aβ1−42 Oligomers on Suppressing the Expression of BDNF, a Beneficial Factor for Inhibiting …
1115. Amelioration of Huntington’s disease phenotypes by Beta-Lapachone is associated with increases in Sirt1 expression, CREB phosphorylation and PGC-1α …
1116. Cell-specific deletion of PGC-1α from medium spiny neurons causes transcriptional alterations and age-related motor impairment
1117. Protective effects of PGC-1α via the mitochondrial pathway in rat brains after intracerebral hemorrhage
1118. Ampelopsin attenuates the atrophy of skeletal muscle from d-gal-induced aging rats through activating AMPK/SIRT1/PGC-1α signaling cascade
1119. TWEAK/Fn14 promotes oxidative stress through AMPK/PGC-1α/MnSOD signaling pathway in endothelial cells
1120. PGC-1α–FNDC5–BDNF signaling pathway in skeletal muscle confers resilience to stress in mice subjected to chronic social defeat
1121. The effects of high-intensity interval training vs. moderate-intensity continuous training on serum irisin and expression of skeletal muscle PGC-1α gene in male rats
1122. Pyrroloquinoline quinone resists denervation-induced skeletal muscle atrophy by activating PGC-1α and integrating mitochondrial electron transport chain …
1123. Bhlhe40 represses PGC-1α activity on metabolic gene promoters in myogenic cells
1124. BPDE and B [a] P induce mitochondrial compromise by ROS-mediated suppression of the SIRT1/TERT/PGC-1α pathway in spermatogenic cells both in vitro and in …
1125. PGC-1α in aging and lifelong exercise training-mediated regulation of UPR in mouse liver
1126. Gpbar1 agonism promotes a PGC-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice
1127. High-intensity high-volume swimming induces more robust signaling through PGC-1α and AMPK activation than sprint interval swimming in m. triceps brachii
1128. spargel, the PGC-1α homologue, in models of Parkinson disease in Drosophila melanogaster
1129. PGC-1α limits angiotensin II-induced rat vascular smooth muscle cells proliferation via attenuating NOX1-mediated generation of reactive oxygen species
1130. … and Glycolipid Metabolism of Blunt Snout Bream Megalobrama amblycephala Fed High-Carbohydrate Diets by Activating the AMPK–SIRT1–PGC-1α …
1131. … in metabolic organs and modulate systemic parameters independently of skeletal muscle peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α …
1132. Sestrin2 facilitates glutamine‐dependent transcription of PGC‐1α and survival of liver cancer cells under glucose limitation
1133. Reversal of defective mitochondrial biogenesis in limb-girdle muscular dystrophy 2D by independent modulation of histone and PGC-1α acetylation
1134. δ-Tocopherol promotes thermogenic gene expression via PGC-1α upregulation in 3T3-L1 cells
1135. Deciphering the molecular mechanism during doxorubicin-mediated oxidative stress, apoptosis through Nrf2 and PGC-1α in a rat testicular milieu
1136. Metabolic regulation by the PGC-1α and PGC-1β coactivators in larval zebrafish (Danio rerio)
1137. Green Tea (−)-Epigallotocatechin-3-Gallate induces PGC-1α gene expression in HepG2 cells and 3T3-L1 adipocytes
1138. A PGC-1α-mediated transcriptional network maintains mitochondrial redox and bioenergetic homeostasis against doxorubicin-induced toxicity in human …
1139. Glucose restriction promotes osteocyte specification by activating a PGC-1α-dependent transcriptional program
1140. Kavain reduces Porphyromonas gingivalis–induced adipocyte inflammation: Role of PGC-1α signaling
1141. Thymoquinone inhibits angiotensin II-induced proliferation and migration of vascular smooth muscle cells through the AMPK/PPARγ/PGC-1α pathway
1142. Adipose triglyceride lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARα-PGC-1α antioxidant response
1143. PGC-1α-dependent mitochondrial adaptation is necessary to sustain IL-2-induced activities in human NK cells
1144. Overexpression of PGC-1α enhances cell proliferation and tumorigenesis of HEK293 cells through the upregulation of Sp1 and Acyl-CoA binding protein
1145. Ropivacaine impairs mitochondrial biogenesis by reducing PGC-1α
1146. Effects of eicosapentaenoic acid and docosahexaenoic acid on mitochondrial DNA replication and PGC-1α gene expression in C2C12 muscle cells
1147. PGC-1α-mediated mitochondrial biogenesis is involved in cannabinoid receptor 2 agonist AM1241-induced microglial phenotype amelioration
1148. Tetrahydroxystilbene glucoside delayed senile symptoms in old mice via regulation of the AMPK/SIRT1/PGC-1α signaling cascade
1149. PGC-1α and Nr4a1 are target genes of circadian melatonin and dopamine release in murine retina
1150. Antifibrotic role of PGC-1α-siRNA against TGF-β1-induced renal interstitial fibrosis
1151. Muscle type-specific RNA polymerase II recruitment during PGC-1α gene transcription after acute exercise in adult rats
1152. … with endoplasmic reticulum stress alleviated heart ischemia/reperfusion injury via modulating IRE1/ATF6/RACK1/PERK and PGC-1α in diabetes mellitus
1153. Quercetin induces mitochondrial biogenesis in experimental traumatic brain injury via the PGC-1α signaling pathway
1154. Yiqihuoxue decoction protects against post-myocardial infarction injury via activation of cardiomyocytes PGC-1α expression
1155. The single nucleotide polymorphism Gly482Ser in the PGC-1α gene impairs exercise-induced slow-twitch muscle fibre transformation in humans
1156. PPARγ/PGC-1α-Fndc5 pathway up-regulation in gastrocnemius and heart muscle of exercised, branched chain amino acid diet fed mice
1157. Atorvastatin attenuates myocardial hypertrophy in spontaneously hypertensive rats via the C/EBPβ/PGC-1α/UCP3 pathway
1158. Effect of electroacupuncture combined with treadmill exercise on body weight and expression of PGC-1α, Irisin and AMPK in skeletal muscle of diet-induced obesity …
1159. Dehydroepiandrosterone activates AMP kinase and regulates GLUT4 and PGC-1α expression in C2C12 myotubes
1160. PGC-1α in exercise and fasting-induced regulation of hepatic UPR in mice
1161. Protective effects of exogenous NaHS against sepsis-induced myocardial mitochondrial injury by enhancing the PGC-1α/NRF2 pathway and mitochondrial …
1162. Coordinated regulation of hepatic FoxO1, PGC-1α and SREBP-1c facilitates insulin action and resistance
1163. Sitagliptin promotes mitochondrial biogenesis in human SH‐SY5Y cells by increasing the expression of PGC‐1α/NRF1/TFAM
1164. A peptide isolated from Hippocampus abdominalis improves exercise performance and exerts anti-fatigue effects via AMPK/PGC-1α pathway in mice
1165. Effect of resistance exercise intensity on the expression of PGC-1α isoforms and the anabolic and catabolic signaling mediators, IGF-1 and myostatin, in human …
1166. Chikusetsu saponin V attenuates H2O2-induced oxidative stress in human neuroblastoma SH-SY5Y cells through Sirt1/PGC-1α/Mn-SOD signaling pathways
1167. Mild aerobic training with blood flow restriction increases the hypertrophy index and MuSK in both slow and fast muscles of old rats: Role of PGC-1α
1168. Prep1 regulates angiogenesis through a PGC‐1α‐mediated mechanism
1169. PGC‐1α inhibits polyamine metabolism in Cyclin E1‐driven ovarian cancer
1170. PGC-1α protects against oxidized low-density lipoprotein and luteinizing hormone-induced granulosa cells injury through ROS-p38 pathway
1171. Epigallocatechin gallate reduces slow-twitch muscle fiber formation and mitochondrial biosynthesis in C2C12 cells by repressing AMPK activity and PGC-1α …
1172. MicroRNA-19b/221/222 induces endothelial cell dysfunction via suppression of PGC-1α in the progression of atherosclerosis
1173. Loss of renal tubular PGC-1α exacerbates diet-induced renal steatosis and age-related urinary sodium excretion in mice
1174. Liquiritigenin protects rats from carbon tetrachloride induced hepatic injury through PGC-1α pathway
1175. HS218 as an FXR antagonist suppresses gluconeogenesis by inhibiting FXR binding to PGC-1α promoter
1176. The genomic context and corecruitment of SP1 affect ERRα coactivation by PGC-1α in muscle cells
1177. Disruption of peroxisome proliferator–activated receptor γ coactivator (PGC)-1α reverts key features of the neoplastic phenotype of glioma cells
1178. Expression of fatty acid synthase is regulated by PGC-1α and contributes to increased cell proliferation
1179. Triptolide improves cognitive dysfunction in rats with vascular dementia by activating the SIRT1/PGC-1α signaling pathway
1180. CTRP9 ameliorates cellular senescence via PGC-1α/AMPK signaling in mesenchymal stem cells
1181. Response of BAX, Bcl-2 proteins, and SIRT1/PGC-1α mRNA expression to 8-week treadmill running in the aging rat skeletal muscle
1182. Transcriptional coactivator NT‐PGC‐1α promotes gluconeogenic gene expression and enhances hepatic gluconeogenesis
1183. Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1α Promoter Activity
1184. CTRP3 promotes energy production by inducing mitochondrial ROS and up-expression of PGC-1α in vascular smooth muscle cells
1185. Interleukin 6 modulates PPARα and PGC-1α and is involved in high-fat diet induced cardiac lipotoxicity in mouse
1186. AMPK activation of PGC-1α/NRF-1-dependent SELENOT gene transcription promotes PACAP-induced neuroendocrine cell differentiation through tolerance to …
1187. A single bout of whole‐leg, peristaltic pulse external pneumatic compression upregulates PGC‐1α mRNA and endothelial nitric oxide sythase protein in human …
1188. Endurance exercise resistance to lipotoxic cardiomyopathy is associated with cardiac NAD+/dSIR2/PGC-1α pathway activation in old Drosophila
1189. PGC-1α Suppresses the Activation of TGF-β/Smad Signaling via Targeting TGFβRI Downregulation by let-7b/c Upregulation
1190. Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1α/PPARα-FGF21 signaling pathway in male Sprague Dawley rats …
1191. Arsenic-induced mitochondrial oxidative damage is mediated by decreased PGC-1α expression and its downstream targets in rat brain
1192. … and bilirubin by chlorogenic acid against hepatotoxicity and cholestasis in bile duct ligation rats: involvement of SIRT1‐mediated deacetylation of FXR and PGC‐1α
1193. Traditional Chinese medicine Qiliqiangxin attenuates phenylephrine-induced cardiac hypertrophy via upregulating PPARγ and PGC-1α
1194. Gluconeogenesis, lipogenesis, and HBV replication are commonly regulated by PGC-1α-dependent pathway
1195. Montelukast promotes mitochondrial biogenesis via CREB/PGC-1α in human bronchial epithelial cells
1196. PGC-1α expression in murine AgRP neurons regulates food intake and energy balance
1197. Systematic meta-analysis revealed an association of PGC-1α rs8192678 polymorphism in type 2 diabetes mellitus
1198. The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1-and PGC-1α-mediated regulation of Glut2
1199. d-Fagomine Attenuates High Glucose-Induced Endothelial Cell Oxidative Damage by Upregulating the Expression of PGC-1α
1200. PGC‐1α in Melanoma: A Key Factor for Antioxidant Response and Mitochondrial Function
1201. … Accumulation, Mitochondrial Dysfunction, and Insulin Resistance in Skeletal Muscle of Ageing Rats: Dual Stimulation of the AMPK/PGC‐1α Signaling Pathway via …
1202. KLF5 overexpression attenuates cardiomyocyte inflammation induced by oxygen-glucose deprivation/reperfusion through the PPARγ/PGC-1α/TNF-α signaling …
1203. Metformin increases cardiac rupture after myocardial infarction via the AMPK-MTOR/PGC-1α signaling pathway in rats with acute myocardial infarction
1204. More than mitochondrial biogenesis: alternative roles of PGC-1α in exercise adaptation
1205. Relationship of PGC-1α gene polymorphism with insulin resistance syndrome in Korean children
1206. High glucose and free fatty acids induce endothelial progenitor cell senescence via PGC‐1α/SIRT1 signaling pathway
1207. An unexpected role for the transcriptional coactivator isoform NT-PGC-1α in the regulation of mitochondrial respiration in brown adipocytes
1208. PGC-1α is responsible for survival of multiple myeloma cells under hyperglycemia and chemotherapy
1209. Deletion of the transcription factor PGC-1α in mice negatively regulates bone mass
1210. PGC-1α silencing compounds the perturbation of mitochondrial function caused by mutant SOD1 in skeletal muscle of ALS mouse model
1211. PGC‐1α/SNAI1 axis regulates tumor growth and metastasis by targeting miR‐128b in gastric cancer
1212. Expression of the gene coading for PGC-1α in peripheral blood leukocytes and related gene variants in patients with Parkinson’s disease
1213. Eccentric resistance training and β-hydroxy-β-methylbutyrate free acid affects muscle PGC-1α expression and serum irisin, nesfatin-1 and resistin in rats
1214. mRNA expression levels of PGC-1α in a transgenic and a toxin model of Huntington’s disease
1215. The role of PGC-1α and MRP1 in lead-induced mitochondrial toxicity in testicular Sertoli cells
1216. Muscle PGC-1α is required for long-term systemic and local adaptations to a ketogenic diet in mice
1217. Quercetin and quercetin-rich red onion extract alter PGC-1α promoter methylation and splice variant expression
1218. Transcriptional coactivator PGC-1α contains a novel CBP80-binding motif that orchestrates efficient target gene expression
1219. Overexpression of NAD (P) H: quinone oxidoreductase 1 inhibits hepatocellular carcinoma cell proliferation and induced apoptosis by activating AMPK/PGC-1α …
1220. … and memory in scopolamine-treated mice by reducing acetylcholinesterase activity and attenuating oxidative damage through SIRT1-PGC-1α-Tau signaling pathway
1221. NT-PGC-1α deficiency decreases mitochondrial FA oxidation in brown adipose tissue and alters substrate utilization in vivo
1222. Bouchardatine suppresses rectal cancer in mice by disrupting its metabolic pathways via activating the SIRT1-PGC-1α-UCP2 axis
1223. Cardiomyocytes are protected from antiretroviral nucleoside analog-induced mitochondrial toxicity by overexpression of PGC-1α
1224. Supplementation with an insoluble fiber obtained from carob pod (Ceratonia siliqua L.) rich in polyphenols prevents dyslipidemia in rabbits through SIRT1/PGC-1α …
1225. Interaction effect of PGC-1α rs10517030 variants and energy intake in the risk of type 2 diabetes in middle-aged adults
1226. Alteration of muscle fiber characteristics and the AMPK-SIRT1-PGC-1α axis in skeletal muscle of growing pigs fed low-protein diets with varying branched …
1227. The effects of PGC-1α on the proliferation and energy metabolism of malignant endometrial cancer cells
1228. Lutein upregulates the PGC‐1α, NRF1, and TFAM expression by AMPK activation and downregulates ROS to maintain mtDNA integrity and mitochondrial biogenesis …
1229. RETRACTED ARTICLE: MiR-138-5p exacerbates hypoxia/reperfusion-induced heart injury through the inactivation of SIRT1-PGC-1α
1230. Low-intensity exercise in the acute phase of lipopolysaccharide-induced sepsis improves lipid metabolism and survival in mice by stimulating PGC-1α expression
1231. Association of combined genetic variations in PPARγ, PGC-1α, and LXRα with coronary artery disease and severity in Thai population
1232. Mice Lacking the Transcriptional Coactivator PGC-1α Exhibit Hyperactivity
1233. trans-Cinnamaldehyde stimulates mitochondrial biogenesis through PGC-1α and PPARβ/δ leading to enhanced GLUT4 expression
1234. Inter-tissue expression patterns of the key metabolic biomarker PGC-1α in severely obese individuals: implication in obesity-induced disease
1235. miR-696 plays a role in hepatic gluconeogenesis in ob/ob mice by targeting PGC-1α
1236. Gastric bypass surgery improves the skeletal muscle ceramide/S1P ratio and upregulates the AMPK/SIRT1/PGC-1α pathway in Zucker diabetic fatty rats
1237. Nitrosporeusine A attenuates sepsis-associated acute kidney injury through the downregulation of IL-6/sIL-6R axis activation-mediated PGC-1α suppression
1238. PGC-1α overexpression suppresses blood pressure elevation in DOCA-salt hypertensive mice
1239. Thyroid hormone induces PGC-1α during dendritic outgrowth in mouse cerebellar Purkinje cells
1240. Effects of diet and arginine treatment during the luteal phase on ovarian NO/PGC-1α signaling in ewes
1241. Cardiac differentiation of mouse embryonic stem cells is influenced by a PPAR γ/PGC-1α—FNDC5 pathway during the stage of cardiac precursor cell formation
1242. BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic …
1243. Browning of pig white preadipocytes by co-overexpressing pig PGC-1α and mice UCP1
1244. Improved endogenous epoxyeicosatrienoic acid production mends heart function via increased PGC 1α-mitochondrial functions in metabolic syndrome
1245. … acid oxidation and gluconeogenesis and on peroxisome proliferator-activated receptor gamma coactivator-1α,(PGC-1α), peroxisome proliferator-activated …
1246. PGC-1α ameliorates AngiotensinII-induced eNOS dysfunction in human aortic endothelial cells
1247. PGC-1α plays a major role in the anti-apoptotic effect of 15-HETE in pulmonary artery endothelial cells
1248. Impact of liver PGC‐1α on exercise and exercise training‐induced regulation of hepatic autophagy and mitophagy in mice on HFF
1249. The effect of 8 weeks of high intensity interval training on the expression of PGC-1α and VEGF genes in myocardial muscle of male healthy rats
1250. A CRM1 inhibitor alleviates cardiac hypertrophy and increases the nuclear distribution of NT-PGC-1α in NRVMs
1251. Fucoidan suppresses mitochondrial dysfunction and cell death against 1-methyl-4-phenylpyridinum-induced neuronal cytotoxicity via regulation of PGC-1α expression
1252. Fat and bone: PGC-1α regulates mesenchymal cell fate during aging and osteoporosis
1253. HuoXue QianYang QuTan Recipe attenuates left ventricular hypertrophy in obese hypertensive rats by improving mitochondrial function through SIRT1/PGC-1α …
1254. PGC‐1α gene transfer improves muscle function in dystrophic muscle following prolonged disease progress
1255. Recruitment of RNA polymerase II to metabolic gene promoters is inhibited in the failing heart possibly through PGC-1α (Peroxisome Proliferator-Activated Receptor-γ …
1256. RIP140/PGC-1α axis involved in vitamin A-induced neural differentiation by increasing mitochondrial function
1257. The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of PGC-1α and Pink1
1258. Rs1894720 polymorphism in MIAT increased susceptibility to age‐related hearing loss by modulating the activation of miR‐29b/SIRT1/PGC‐1α signaling
1259. Human muscle precursor cells overexpressing PGC-1α enhance early skeletal muscle tissue formation
1260. The effects of interval training intensity on skeletal muscle PGC-1α in type2 diabetic male rats
1261. Salicylates promote mitochondrial biogenesis by regulating the expression of PGC-1α in murine 3T3-L1 pre-adipocytes
1262. Acute simulated soccer-specific training increases PGC-1α mRNA expression in human skeletal muscle
1263. Lack of age-related clinical progression in PGC-1α-deficient mice–implications for mitochondrial encephalopathies
1264. Inhibition of PGC-1α after chemotherapy-mediated insult confines multiple myeloma cell survival by affecting ROS accumulation
1265. Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast CancerShcA Signaling Controls Breast Tumor Metabolism
1266. Inhibitory effects of SRT1720 on the apoptosis of rabbit chondrocytes by activating SIRT1 via p53/bax and NF-κB/PGC-1α pathways
1267. Dexamethasone mediated downregulation of PGC-1α and visfatin regulates testosterone synthesis and antioxidant system in mouse testis
1268. mRNA PGC-1α levels in blood samples reliably correlates with its myocardial expression: study in patients undergoing cardiac surgery
1269. Muscle PGC‐1α in exercise and fasting‐induced regulation of hepatic UPR in mice
1270. Identification of PGC-1α activating constituents in Zingiberaceous crude drugs
1271. Peroxisome proliferator-activated receptor-γ–coactivator 1α (PGC-1α) gene expression in chronic kidney disease patients on hemodialysis: relation to hemodialysis …
1272. Histopathological comparison of Kearns-Sayre syndrome and PGC-1α-deficient mice suggests a novel concept for vacuole formation in mitochondrial encephalopathy
1273. Interleukin-6 affects aging-related changes of the pparα-PGC-1α axis in the myocardium
1274. Adiponectin partially rescues high glucose/high fat-induced impairment of mitochondrial biogenesis and function in a PGC-1α dependent manner.
1275. Concerted action of histone methyltransferases G9a and PRMT-1 regulates PGC-1α-RIG-I axis in IFNγ treated glioma cells
1276. Regulation on SIRT1-PGC-1α/Nrf2 pathway together with selective inhibition of aldose reductase makes compound hr5F a potential agent for the treatment of diabetic …
1277. Modulation of cardiac vascular endothelial growth factor and PGC-1α with regular postexercise cold-water immersion of rats
1278. Phosphorylation of 4EBP by oral leucine administration was suppressed in the skeletal muscle of PGC-1α knockout mice
1279. Non-motor Behavioral Alterations of PGC-1α-Deficient Mice–A Peculiar Phenotype With Slight Male Preponderance and No Apparent Progression
1280. Lack of PGC-1α exacerbates high glucose-induced apoptosis in human umbilical vein endothelial cells through activation of VADC1
1281. Bofutsushosan ameliorates obesity in mice through modulating PGC-1α expression in brown adipose tissues and inhibiting inflammation in white adipose tissues
1282. The influence of ethnicity in the association of WC, WHR, hypertension and PGC-1α (Gly482Ser), UCP2− 866 G/A and SIRT1− 1400 T/C polymorphisms with T2D in …
1283. … selenium intake from enriched milk casein impairs hepatic insulin sensitivity via attenuated IRS/PI3K/AKT signaling and decreased PGC-1α expression in male …
1284. Effect of eight weeks aerobic and combined training on serum levels of sirtuin 1 and PGC-1α in coronary artery bypass graft patients
1285. PGC‐1α in hepatic UPR during high‐fat high‐fructose diet and exercise training in mice
1286. The effect of aerobic exercise and caloric restriction on mice’s brain tissue PGC-1α levels and their memory abilities
1287. A20 deubiquitinase controls PGC-1α expression in the adipose tissue
1288. Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts
1289. Lifelong parental voluntary wheel running increases offspring hippocampal PGC-1α mRNA expression but not mitochondrial content or Bdnf expression
1290. GCN-5/PGC-1α signaling is activated and associated with metabolism in cyclin E1-driven ovarian cancer
1291. PGC-1α induced browning promotes involution and inhibits lactation in mammary glands
1292. Rosiglitazone, but not epigallocatechin-3-gallate, attenuates the decrease in PGC-1α protein levels in palmitate-induced insulin-resistant C2C12 cells
1293. The potential use of PGC-1α and PGC-1β to protect the retina by stimulating mitochondrial repair
1294. Exercise and PGC-1α in inflammation and chronic disease
1295. NGF promotes mitochondrial function by activating PGC‐1α in TM 4 Sertoli cells
1296. β1-and β2-adrenergic receptor stimulation differ in their effects on PGC-1α and atrogin-1/MAFbx gene expression in chick skeletal muscle
1297. … -1α (PGC-1α) regulates the expression of B-cell lymphoma/leukemia-2 (Bcl-2) and promotes the survival of mesenchymal stem cells (MSCs) via PGC-1α …
1298. PGC‐1α regulates the expression and activity of IRF‐1
1299. Mitochondrial biogenesis and PGC‐1α gene expression in male broilers from ascites‐susceptible and‐resistant lines
1300. … ‐thyroid hormone combined protocol as a novel approach to metabolic stress disorders: Relation to mitochondrial adaptation via liver PGC‐1α and sirtuin1 activation
1301. Opposing action of NCoR1 and PGC-1α in mitochondrial redox homeostasis
1302. A Novel Danshensu-tetramethylpyrazine conjugate DT-018 provides cardioprotection by preserving mitochondrial function through the MEF2D/PGC-1α pathway
1303. Constitutive PGC-1α Overexpression in Skeletal Muscle Does Not Improve Morphological Outcome in Mouse Models of Brain Irradiation or Cortical Stroke
1304. Cytotoxicity of Malondialdehyde and Cytoprotective Effects of Taurine via Oxidative Stress and PGC-1α Signal Pathway in C2C12 Cells
1305. Association of PGC-1α gene with type 2 diabetes in three unrelated endogamous groups of North-West India (Punjab): a case-control and meta-analysis study
1306. Improvement of the physical performance is associated with activation of NO/PGC-1α/mtTFA signaling pathway and increased protein expressions of electron …
1307. Comparisons of different myosin heavy chain types, AMPK, and PGC-1α gene expression in the longissimus dorsi muscles in Bama Xiang and Landrace pigs
1308. The transcriptional modulator Ifrd1 controls PGC‐1α expression under short‐term adrenergic stimulation in brown adipocytes
1309. Decreased PGC-1α post-cardiopulmonary bypass leads to impaired oxidative stress in diabetic patients
1310. Phytol promotes the formation of slow-twitch muscle fibers through PGC-1α/mirna but not mitochondria oxidation
1311. A key role of PGC‐1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA‐Cl in cultured human fibroblasts
1312. Thyroid hormone-stimulated increases in PGC-1α and UCP2 promote life history-specific endocrine changes and maintain a lipid-based metabolism
1313. Low pre‐exercise muscle glycogen availability offsets the effect of post‐exercise cold water immersion in augmenting PGC‐1α gene expression
1314. Delayed puberty by ziram is associated with down regulation of testicular phosphorylated AKT1 and SIRT1/PGC-1α signaling
1315. Blood PGC-1α concentration predicts myocardial salvage and ventricular remodeling after ST-segment elevation acute myocardial infarction
1316. The effect of endurance training on gene expression of PGC-1α, BDNF and learning disorders in the hippocampus of aging rats
1317. Mineral-enriched deep-sea water modulates lactate metabolism via PGC-1α-mediated metabolic reprogramming
1318. Sustained elevation of NF-κB activity sensitizes offspring of maternal inflammation to hypertension via impairing PGC-1α recovery
1319. The effect of aerobic training with Citrus aurantium L. on SIRT1 and PGC-1α gene expression levels in the liver tissue of elderly rats
1320. Changes in the PGC-1α and mtDNA copy number may play a role in the development of pelvic organ prolapse in pre-menopausal patients
1321. Enhanced therapeutic potential of the secretome released from adipose-derived stem cells by PGC-1α-driven upregulation of mitochondrial proliferation
1322. Synergism between PGC-1α and estrogen in the survival of endometrial cancer cells via the mitochondrial pathway
1323. Hepatic MicroRNA Expression by PGC-1α and PGC-1β in the Mouse
1324. Small interfering RNA targeting PGC-1α inhibits VEGF expression and tube formation in human retinal vascular endothelial cells
1325. Yiqi Yangyin and Huatan Quyu granule can improve skeletal muscle energy metabolism in a type 2 diabetic rat model by promoting the AMPK/SIRT/PGC-1α …
1326. The Effect Of PGC-1α On Acute Lung Injury
1327. Inhibition of adhesion molecule gene expression and cell adhesion by the metabolic regulator PGC-1α
1328. Dose‐and time‐dependent alterations in lipid metabolism after pharmacological PGC‐1α activation in L6 myotubes
1329. The effect of eight weeks of water training on Sirt1, PGC-1α and body fat percentage in obese men
1330. PGC-1α concentration in skeletal muscle by exercise is controlled by PPARβ/δ through post-transcriptional mechanism: the effects of PPARβ/δ silence on PGC-1α …
1331. PGC-1α coordinates with Bcl-2 to control the cell cycle in U251 cells through reducing ROS
1332. Effects of 4 week endurance training on PGC-1α expression in adipose tissue, ANGPTL8 serum concentrations and beta cells function of STZ diabetic rats
1333. Orchestrating Metabolic Flexibility: PGC-1α and Clinical Heart Failure
1334. Transcriptional coactivator PGC-1α binding to newly synthesized RNA via CBP80: a nexus for co-and posttranscriptional gene regulation
1335. … gene enhances aerobic metabolism of themselves and mitochondrial respiration of mammal cells to bring about improving metabolic syndrome through the PGC‐1α …
1336. New wine into old wineskins: PGC‐1α and NF‐κB in obesity and acute pancreatitis
1337. Injected Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Functional Muscle Regeneration after Trauma
1338. Gene and Protein Expression Profile of Selected Molecular Targets Mediating Electrophysiological Function in PGC-1α Deficient Murine Atria
1339. Control of secreted protein gene expression and the mammalian secretome by the metabolic regulator PGC-1α
1340. … for three days reduces whole body glucose uptake, impairs muscle mitochondrial function and initiates opposing effects on PGC-1α promoter methylation in …
1341. Easily performed interval exercise induces to increase in skeletal muscle PGC-1α gene expression
1342. A feed-forward circuit of endogenous PGC-1α and estrogen related receptor α regulates the neuronal electron transport chain
1343. THE EFFECT OF 8 WEEKS AEROBIC TRAINING ON CARDIAC PGC-1α AND PLASMA IRISIN IN STZ-INDUCED DIABETICS’RATS
1344. Erratum: PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity
1345. Retraction Notice to: Activation of the PPAR/PGC-1α Pathway Prevents a Bioenergetic Deficit and Effectively Improves a Mitochondrial Myopathy Phenotype
1346. Regulation of Hepatic Gluconeogenesis by NT‐PGC‐1α, the short isoform of PGC‐1α
1347. PPARβ/δOverexpression Increase PGC-1αProtein through the Decreased PGC-1α Ubiquitination in Mouse Skeletal Muscle.
1348. Examining the Impact of Different Exercise Protocols on PGC‐1α and FNDC5 mRNA Expression in Human Skeletal Muscle
1349. Correction to: Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α‘
1350. GW27-e0632 NR reduced myocardial ischemia-reperfusion injury by improving mitochondrial biogenesis and reducing excessive autophagy via Sirt3-PGC-1α/P53 …
1351. The effects of PDK4 inhibition on AMPK protein levels and PGC-1α gene expression following endurance training in skeletal muscle of Wistar rats
1352. Saponins from Rhizoma Panacis Majoris attenuate myocardial ischemia/reperfusion injury via the activation of the Sirt1/Foxo1/PGC-1α and Nrf2/antioxidant defense …
1353. Exploring the Regulation of PGC-1α-Investigating the Gly482Ser Polymorphism of PGC-1a and the PGC-1α4 Isoform
1354. dl-3n-butylphthalide reduces oxygen-glucose deprivation-induced endothelial cell damage by increasing PGC-1α
1355. Acute Exercise‐Induced Mitophagy is Mediated in Part by PGC‐1α
1356. The Effect of Four Weeks of High-intensity Interval Training on PGC-1α and VEGF Protein Contents in Skeletal Muscle of Active Men
1357. The cancer drug dasatinib increases PGC-1α in adipose tissue but has adverse effects on glucose tolerance in obese mice
1358. Effects of myostatin deficiency on PGC-1α and FNDC5 expression in three different murine muscle types
1359. The effect of high intensity interval training and moderate intensity continuous training on mitochondrial content and PGC-1α of subcutaneous adipose tissue in male …
1360. Investigating Methylated Arginine Residues in PGC‐1α
1361. Effects of cadmium chloride on mitochondrial function and PGC-1α expression in HK-2 cells
1362. The Role and Regulation of PGC-1α and PGC-1β in Skeletal Muscle Adaptation
1363. The Combination of Aerobic and Resistance Exercise Induces Weight Loss via the PGC-1α/Irisin/UCP-1 Pathway
1364. Astaxanthin Attenuates Hepatic Damages and Mitochondrial Dysfunction in Nonalcoholic Fatty Liver Disease by Regulating the FGF21/PGC-1α Pathway
1365. Effect of electroacupuncture on the expression of PGC-1α and UCP-1 in the brown adipose tissue of obese rats
1366. PGC-1α overexpression via local in vivo transfection in mouse skeletal muscle
1367. Overexpression of PGC‐1α Increases Peroxisomal Biogenesis and Mitochondrial Lipid Oxidation in Human Primary Myotubes
1368. … Houtt, and Gardenia jasminoides Ellis fruit attenuates the exacerbation of energy, lipid, and glucose by increasing hepatic PGC-1α expression in estrogen …
1369. PGC-1α is associated with Schizothorax prenanti myoblast differentiation
1370. PGC-1α overexpression promotes mitochondrial biogenesis to protect auditory cells against cisplatin-induced cytotoxicity
1371. Erratum: PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity
1372. The comparison of the influence of 12-week high-intensity interval training and continuous moderate intensity training on PGC-1α and Tfam mitochondrial proteins …
1373. Effects of aerobic exercise on PGC-1α, AMPK and SOD expression of skeletal muscle in 2type diabetic rats
1374. Arginine induces skeletal muscle fiber type conversion by upregulating Akirin2 and AMPK/PGC-1α in mice
1375. PGC-1α-Derived Peptide Influences Energy in Normal Human Dermal Fibroblasts
1376. Effect of Salicornia herbacea L. supplementation on tissue triglyceride concentrations and PGC-1α & PPAR-γ expression of skeletal muscle of rats fed a high-fat diet
1377. Measuring PGC-1α and Its Acetylation Status in Mouse Primary Myotubes
1378. Nuclear factor‐erythroid 2‐related factor‐2 (Nrf2) and peroxisome proliferator‐activated receptor γ coactivator‐1α (PGC‐1α) regulates proteolysis in cornea
1379. An Optimized Immunoblotting Protocol for Accurate Detection of Endogenous PGC-1α Isoforms in Various Rodent Tissues
1380. Endurance exercise increases the protein levels of PGC-1α and respiratory chain complexes in mouse skeletal muscle during atorvastatin administration
1381. Over-expression of PGC-1α reverses mitochondrial function reduction and apoptosis in OGD/R-induced neurons
1382. Erratum. Pathophysiological Mechanism of Bone Loss in Type 2 Diabetes Involves Inverse Regulation of Osteoblast Function by PGC-1α and Skeletal Muscle …
1383. Effect of eight weeks high intensity interval training on gene expression of PGC-1α, in male healthy rats fast-slow twitch muscles
1384. Cloning of PGC-1α from Grass Carp and Its Response to Cadmium-Induced Stress
1385. … of vascular endothelial growth factor (VEGF) and angiogenesis in muscle by N terminus peroxisome proliferator-associated receptor gamma coactivator (NT-PGC)-1α.
1386. Erratum to: The Potential Use of PGC-1α and PGC-1β to Protect the Retina by Stimulating Mitochondrial Repair
1387. A comparison of PGC-1α mRNA and protein expression in response to 1-week endurance training on alternate days or 4 consecutive days
1388. Effects of PGC‐1α Overexpression on Glucocorticoid‐induced Atrophy Signaling in C2C12 Muscle Cells
1389. The effect of aerobic exercise with and without blood flow restriction on lactate, cortisol and PGC-1α response in human skeletal muscle
1390. The Effect of Short Endurance Training on PGC-1α/FNDC5/BDNF Signalling Pathway In 6-OHDA-Induced Parkinson’s Rats
1391. PGC-1α Mediated Peripheral Nerve Protection of Tongxinluo in STZ-Induced Diabetic Rats
1392. Differential expression profile of PGC-1α gene in two phenotypically distinct muscles between two chicken (Gallus gallus) breeds.
1393. S-540 PGC-1α Protects Against Notch1-Induced Kidney Injury
1394. Ibrutinib in combination with venetoclax decreases mitochondrial bioenergetics through the Impaired BTK, AKT and AMPK/SIRT/PGC-1α signaling pathway in …
1395. Neuropathological characterization of FL-PGC-1α-deficient mice–implications for mitochondrial encephalopathy
1396. A comparison of the effect of eight weeks of high intensity interval training on PGC-1α gene expression levels in the slow twitch (ST) and fast twitch (FT) muscles …
1397. The role of NADPH oxidase 2 in regulating IL-15 and PGC-1α gene expressions following a period of high intensity interval training
1398. Effect of Electroacupuncture at Tinggong and Yifeng on D-galactose-induced Aging of Auditory Cortex through SIRT1/PGC-1α Pathway in Guinea Pigs
1399. The role of mitochondrial metabolism and PGC-1α on breast cancer bioenergetics and metastasis
1400. Effects of six-week high-intensity interval training (HIIT) on PGC-1α methylation in gastrocnemius muscle of obese rats
1401. PGC-1α is a critical activator of HO-1 that protects against cardiomyopathy in diabetic mice through recruitment of mitochondrial fusion proteins and function
1402. The role of NADPH oxidase 2 in regulating IL-15 and PGC-1α gene expressions following a period of high intensity interval training.
1403. Isorhamnetin activates Sirt1/PGC-1α signaling pathway to inhibit MPP+-induced SH-SY5Y cell injury
1404. OR-005 Effects of HIITand MICT for 10 weeks on myocardial AMPK and PGC-1α in rats: There is no full paper associated with this abstract
1405. NRF‐2 and PGC‐1α signaling regulate epithelial‐mesenchymal transition in mouse model
1406. Acute influence of mild hyperbaric oxygen at 1.25 atmospheres absolute with normal air on mitochondrial enzymes and PGC-1α mRNA levels in rat skeletal …
1407. Retracted: Treadmill Training Increases SIRT-1 and PGC-1α Protein Levels and AMPK Phosphorylation in Quadriceps of Middle-Aged Rats in an Intensity-Dependent …
1408. Advances in relationship between PGC-1α and tumor metabolism
1409. Correction: Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration
1410. The effect of 3 weeks ergometer cycling training with and without vascular occlusion on Plasma concentration of Irisin and PGC-1α in healthy men
1411. Astragaloside IV attenuates pressure overload-induced cardiac hypertrophy by regulating PGC-1α signaling mediated energy biosynthesis
1412. PGC‐1α, a Novel Substrate for Protein Arginine Methyltransferase 7?
1413. PGC-1α in neurodegeneration and ageing
1414. Expression patterns of PPARγ2, PGC-1α, and MEF2C and their association with intramuscular fat content and skeletal muscle tenderness of crossbred Simmental …
1415. The effect of 14 weeks aerobic exercise on resveratrol supplementation on protein UCP-1, SIRT1, PGC-1α in liver tissue, subcutaneous and visceral fat tissue in male …
1416. Comparison of the Effects of Endurance Training on Alternate Days and on Consecutive 4 Days Each Week for 8 Weeks on the Abundance of PGC-1α, CaMKII, NRF-1 …
1417. GW26-e4506 Losartan cannot weaken the change of PGC-1α/NT-PGC-1α altered by Metformin in myocardial cells
1418. NRF-2/PGC-1α deficiency induces retinal degeneration in mice
1419. Correlation between PGC-1α gene polymorphism and metabolic diseases
1420. Local skeletal muscle heating and cooling impacts PGC-1β, but not PGC-1α expression after resistance exercise
1421. The Correlation Between Tfeb and PGC‐1α in Skeletal Muscle
1422. Relationship between hepatitis C virus and the transcription coactivator PGC-1α–A review
1423. Oxidative Phosphorylation Regulated By PGC-1α Promotes Multiple Myeloma Progression
1424. Generation of GABAergic interneuron-specific PGC-1α knockout mice
1425. CRTC2 Contributes to PGC‐1α Expression in Skeletal Muscle Cells
1426. The activation of PGC-1α protects the liver from IR damage
1427. Effect of hibiscus sabdariffa linn methanolic extract on heart hypertrophy index and PGC-1α in overtrained rat
1428. PL-020 Establishment of skeletal muscle-specific PGC-1α overexpression model via in vivo local transfection: There is no full paper associated with this abstract
1429. The effect of endurance training in air pollution on the expression of brain cortex PGC-1α and Atf2 genes in Wistar male rats
1430. Neuroprotective effects of PGC-1α activators in dopaminergic neurons
1431. PGC-1α is required to maintain RPE metabolism, integrity and function.
1432. PO-015 Meta-analysis on the relationship between PGC-1α-482 genetic polymorphism and exercise intervention in insulin resistance: There is no full text article …
1433. Control of human RPE differentiation and metabolism by PGC-1α: implications for AMD
1434. The expression of PGC-1α in carotid atherosclerotic plaque induced by cytomegalovirus
1435. PGC-1α Promoter Histone Acetylation is Life Saving in Fibrotic Hepatectomy
1436. Transcriptional Activation of PGC‐1α in Skeletal Muscle: Influence of Aging and Exercise
1437. Effect of exogenous PGC-1α on VEGF expression in human retinal vascular endothelial cells
1438. Pharmaceutical induction of PGC-1α protects retinal pigment epithelium from oxidative stress
1439. Relationship Between The Expression of PGC-1α and Muscle Fatigue In ApcMin/+ Mice.
1440. Associations of PPARG and PGC-1α gene polymorphisms with body structure
1441. The Aging Muscle Milieu and Transcription of PGC‐1α: a Role for Contractile Activity?
1442. Oscillatory Gene Promoter Regulation by PGC-1α and Sirt1 in Cardiac Energy Metabolism
1443. PGC-1α is important for maintaining the balance of muscle mass and myofiber types in unloaded muscle atrophy
1444. Sirt1 Maintains PGC-1α Function Through Periodic Promoter Release
1445. Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts
1446. Effect of PGC-1α knockdown on zebrafish cells under cold stress.
1447. Regulating Transcriptional Co-Activator PGC-1α for the Treatment of Sickle Cell Disease
1448. Regulation of retinal neovascularization in mice treated by recombinant PGC-1α protein
1449. PGC‐1α‐mediated Changes in Phospholipid Profiles of Exercise‐trained Skeletal Muscle
1450. Transcriptional regulation of kidney and skeletal muscle metabolism by the coactivator PGC-1α
1451. Total or endothelium specific PGC-1α deficiency is associated with alterations in vascular function in mice
1452. PGC-1α Determines the Formation of Neuronal Respiratory Chain Supercomplexes That Regulate Mitochondrial Function
1453. Expression of cytoglobin and PGC-1α is high during tail tissue regeneration of the house gecko (Hemidactylus platyurus)
1454. The Effect of Aerobic Exercise on PGC-1α and FNDC5 Gene Expression in Diabetic Male Rats
1455. Polymorphisms analysis of PGC-1α in 646 Locus of Guangxi Nandan-Yao chicken.
1456. Acute Expression of PGC‐1α Isoforms in Skeletal Muscle of Postmenopausal Women following Resistance Exercise
1457. AMP Deaminase 3 overexpression regulates cellular energetics and signaling for PGC-1α activation.
1458. The Effect of Endurance Training in Air Pollution on the Expression of Muscle Tissue Mitochondria PGC-1α and MEF2C Genes in Wistar Male Rats
1459. Nrf2‐ and PGC‐1α‐deficient mice: A novel animal model for impaired autophagy in AMD?
1460. AMP Deaminase 3 Overexpression Reduces Mitochondrial Content in C2C12 Myotubes by Decreasing PGC‐1α Promotor Activation
1461. Effect of Vitamin E on the Expression of SIRT1 and PGC-1α in Mice with Nonalcoholic Fatty Liver Disease
1462. Neuronal control of energy balance and modulation of muscle aging by the transcriptional coactivator PGC-1α
1463. Stimulation of PGC-1α to attenuate Duchenne muscular dystrophy disease pathology and activate autophagy
1464. Analysis of tissue specific regulatory targets of co-factor PGC-1α using bioinformatics methods
1465. Gluconeogenesis, lipogenesis, and HBV replication are commonly regulated by PGC-1α-dependent pathway
1466. The Molecular Basis of Increased Diabetes Susceptibility in Carriers of the PGC-1α (482Ser) Risk Allele
1467. The alterations of PGC-1α expression and epigenetic modifications in the retina of streptozotocin-induced diabetic rats
1468. PGC‐1α–Dependent TFEB Expression and Activation with Exercise
1469. Anti-inflammatory action of β-hydroxybutyrate via modulation of PGC-1α and FoxO1, mimicking calorie restriction
1470. The Effect of High-Intensity Interval Training in Obese Female Rats before Pregnancy on Fatigue Time, Methylation of PGC-1α and Sarcolipin Genes in the …
1471. Mitochondrial Regulation Downstream of the Transcriptional Coactivator PGC-1α Is Required for NK Cell Function During an Immune Response
1472. Role of Inflammation on Metabolic Transcription Factors: PPARγ and PGC-1α
1473. Loss of PGC-1α function in RPE induces EMT and promotes retinal degeneration
1474. Decreased PGC‐1α‐SIRT1 Signaling Leads to Impaired Angiogenesis in Persistent Pulmonary Hypertension of the Newborn (PPHN)
1475. THE DEFICIENCY OF THE TRANSCRIPTIONAL COACTIVATOR PGC-1α INCREASES RENAL INJURY IN ACUTE KIDNEY INJURY (AKI)
1476. Role of SIRT1 in renal ischemia-reperfusion injury and its effect on NF-κBp65-PGC-1α signal pathway in mice
1477. The Effect of Consumption of Quercetin Supplement on Gene Expression of PGC-1α during Sedentary Period in Active Rats after a HIIT Course
1478. PGC‐1α Upregulates Mitochondrial Sirtuins and Reduces Protein Acetylation in Skeletal Muscle of Old Mice.
1479. PGC-1α regulates mitochondrial calcium homeostasis, SR stress and cell death to mitigate skeletal muscle aging
1480. GW27-e1023 Atorvastain Attenuates TNF-α-induced Increase of Glucose Oxidation Through PGC-1α Upregulation in cardiomyocytes
1481. SAT-120 RESTORATION OF PGC-1α ACTIVITY BY DELETION OF SMAD3 PROTECTS AGAINST KIDNEY INJURY IN CRP TG MICE WITH UNILATERAL URETERAL …
1482. PO-014 The effects of HIIT on ROS-AMPK-PGC-1α pathway in skeletal muscle and VO2max of ageing Wistar rats.: There is no full text article associated with this …
1483. Role of mitochondria in diabetic peripheral Influencing neuropathy: the NAD+-dependent SIRT1–PGC-1α–TFAM pathway
1484. PGC-1α Mediates Differentiation Arrest of Murine Bone Marrow-derived Endothelial Progenitor Cells in Diabetes
1485. Physiological cardiac hypertrophy activates PPARγ/PGC‐1α axis and up‐regulates perilipin family
1486. … PGC-1α, Restores Mitochondrial Function, LV Function, and Ameliorates Development of Cardiovascular Disease in Db Mice That is Reversed by Lentiviral-PGC-1α …
1487. Investigating the effects of rosiglitazone and epigallocatechin-3-gallate on PGC-1α protein expression in palmitate-induced insulin resistant C2C12 skeletal muscle …
1488. Calcium deficiency affects serum glucose and lipids by inhibiting PGC-1α expression in skeletal muscle of rats
1489. PGC-1α regulates mitochondrial-sarcoplasmic reticulum (SR)-mediated calcium exchange, SR stress and cell death to mitigate skeletal muscle aging
1490. Abstract P233: Diabetic Cardiomyopathy is Reversed by Increased Mitochondrial Bioenergetics Due to PGC-1α Activation by EET Treatment of Obese Mice
1491. PGC‐1α Activation Confers Plasticity in the Mediator of Dilation in Healthy and Diseased Human Arterioles
1492. Low-intensity exercise in the acute phase of lipopolysaccharide-induced sepsisimproves lipid metabolism and survival in mice by stimulating PGC-1α …
1493. … Therapy Improves Age-related Collateral Development With Ischemia Through p53 and Peroxisome Proliferator-activated Receptor γ Coactivator-1α (PGC-1α)
1494. Effect Of Eight Weeks Of High Intensity Interval Training On Ampk And PGC-1α Gene Expression Levels In The Soleus Muscles In Rats With Myocardial Infarction
1495. GW27-e0440 Increased nuclear NT-PGC-1α via inhibition of CRM1 can enhance fatty acid oxidation in NRCM
1496. Impact of β-adrenergic signaling in PGC-1α-mediated adaptations in mouse skeletal muscle 2
1497. The Effect of Different Weeks of High Intensity Interval Training and Moderate-intensity Aerobic Exercise on Skeletal Muscle’s AMPK and PGC-1α of Rats
1498. Passive and post-exercise cold-water immersion augments PGC-1α and VEGF expression in human skeletal muscle.
1499. Regulation of endothelial function and angiogenesis by PGC-1α relies on ROS control of vascular stability
1500. Peroxisome Proliferator‐Activated γ Coactivator‐1α (PGC‐1α) mRNA Expression Correlates Highly with mRNA Expression of Myosin Heavy Chain (MHC) Isoforms in …
1501. OR-003 Time-sequential Changes of Myocardial AMPK and PGC-1α Expression during Detraining between High-intensity Interval Training and Moderate-intensity …
1502. Long‐term Quercetin Treatment is Unable to Sustain Elevated PGC‐1α Pathway Activity in the mdx Diaphragm
1503. Lactate administration increases mRNA expression of PGC-1α and UCP3 in mouse skeletal muscle
1504. PGC-1α-mediated Muscle/brain Crosstalk and Antidepressant Effects of Exercise—Reflaction and Prospect from Integrative Biology
1505. THE EFFECTS OF A HIGH-FAT DIET AND EXERCISE ON THE PGC-1α-FNDC5/IRISIN PATHWAY IN C57BL/6 MICE
1506. Enhancing PGC-1α Activity Improves Heart Function Through Activating Mitochondrial Biogenesis in Chagas Disease
1507. The Protumor Role of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha (PGC-1α) In Neuroblastoma
1508. Regulation of SIRT1, sirt3, PGC-1α, and LRP130 in response to energetic stress in human skeletal muscle
1509. Does The Polymorphism Of PGC-1α Influence The Pwv Of The Long-Lived Person Born In The 1940S Who Experienced A Rough Meal In Early Childhood?
1510. Transcription Dysregulation of the PGC-1α Pathway in Huntington’s Disease Pathogenesis: From Metabolic Derangement to Neurodegeneration
1511. Temporal examination of DNA methylation profile reprogramming in the promoter region of PGC-1α during the progression of insulin resistance and type 2 diabetes …
1512. Effects of phlegm-resolving and stasis-removing herbal drugs on PGC-1α mRNA expressions and insulin resistance in NAFLD rats
1513. Mechanistic Control of the Cold-Induced Augmentation of the Transcriptional Co-Activator PGC-1α
1514. The Impact of PGC-1α on Engineered Muscle Tissue and the Use of PET-Scan for Cell Tracking and Functional Analyses
1515. Clear cytoplasm of renal cell carcinoma is more than a morphologic phenotype: relation to drug sensitivity, AMPK/PGC-1α pathway, and mitochondria
1516. Corrigendum: PGC-1α silencing compounds the perturbation of mitochondrial function caused by mutant SOD1 in skeletal muscle of ALS mouse model
1517. Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential
1518. The knockout of aldose reductase accelerates liver regeneration through AMPK/SIRT1/PGC-1α network
1519. Nrf2‐ and PGC‐1α‐deficient mice: A novel animal model for disturbed proteostasis and RPE degeneration
1520. The Nrf2 and PGC-1α deficient murine retina reveals retinal pigment epithelium damage that coincides with autophagy decline and damaged mitochondria.
1521. Effect of Resveratrol Supplementation and Aerobic Exercise on the Protein SIRT1 and PGC-1α Skeletal Muscle and Subcutaneous Fat Tissue’s UCP-1 Levels in …
1522. Abstract P608: Obesity Induced Hypertension Exacerbated Through Upregulation Of Renal Naci Cotransporter, Reversed By Increasing PGC-1α-ho-1 Gene …
1523. Exercise and Regulation of Metabolic Function in Human Skeletal Muscle: with Special Reference to PGC-1α and the Mitochondria
1524. The Effect of 8 Weeks of Aerobic Exercise on the Expression of PGC-1α and VEGF Genes in Healthy Male Rats’ Myocardial Muscle
1525. Nuclear factor-erythroid 2-related factor-2 (Nrf2) and peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) deficient mice: Dissecting the …
1526. … Altered long non-coding RNA expression profile in rabbit atria with atrial fibrillation: TCONS_00016478 modulates atrial energy metabolic remodeling through PGC-1α …
1527. PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity.(Erratum) Aging, 2015; 7 (9): 629‐647.
1528. Protective effects of crocin on myocardial ischemia and hypoxia induced by ischemia and hypoxia through C/EBP-β/PGC-1α/UCP3 in rats
1529. Overexpression of PGC-1α Increases Peroxisomal Activity and Mitochondrial Fatty Acid Oxidation in Human Primary Myotubes 2
1530. Empagliflozin Directly Stimulates PGC-1α-Dependent Mitochondrial Biogenesis in Cardiac Cells; A Potential Mechanism Associated With Its Cardiovascular Benefits
1531. Restoration of PGC-1α activity by deletion of Smad3 protects against kidney injury in CRP TG mice with unilateral ureteral obstruction (UUO)
1532. Gain-of-function mutant p53 enhances mitochondrial ROS through the inhibition of PGC-1α/UCP2 axis in cancer cells
1533. GW26-e4408 The protective effects of salidroside from exhaustive exercise-induced heart injury by enhancing the PGC-1α–NRF1–NRF2 pathway and mitochondrial …
1534. Abstract B27: RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1α-mediated mitochondrial oxidative phosphorylation and glycolysis
1535. Post-exercise cold-water immersion modulates skeletal muscle PGC-1α mRNA expression in immersed and non-immersed limbs: evidence of 2 systemic regulation 3
1536. A Key Role of PGC-1α Co-transcription Factor, but not HIF1α Transcription Factor, in Production of Vascular Endothelial Growth Factor (VEGF) by a Novel Angiogenic …
1537. A single bout of whole-leg, peristaltic pulse external pneumatic compression upregulates PGC-1α mRNA and eNOS protein in human skeletal muscle tissue
1538. Activation of cAMP/CREB/PGC-1α Pathway Plays a Key Role for a Novel Adenosine-like Angiogenic Agent COA-Cl to Induce Production of Vascular Endothelial …
1539. Signalling Through the PGC-1α Pathway Mediates an Inducible Stress Response in Retinal Astrocytes to Resist Oxidative and Metabolic Insults
1540. Obesity, Diabetes and Energy Homeostasis: Thyroid hormone-stimulated increases in PGC-1α and UCP2 promote life history-specific endocrine changes and …
1541. Transcriptional control, but not sub-cellular location, of PGC-1α is altered following 1 exercise in a hot environment 2 3 Heesch, Matthew W1, Shute, Robert J2 …
1542. … OF PHYSICAL PERFORMANCE IN 5/6 NEPHRECTOMIZED CKD MODEL MICE THROUGH EPIGENETIC MODULATION OF PGC-1α EXPRESSION BY A GASTRIC …
1543. Epigenetic modifications of the PGC-1α promoter in Limb Girdle Muscular Dystrophy 2D account for impaired mitochondrial biogenesis: new perspective in HDAC …
1544. Mitochondrial metabolism is inhibited by the HIF 1α‐MYC‐PGC‐1β axis in BRAF V600E thyroid cancer
1545. PGC-1α, inflammation, and oxidative stress: an integrative view in metabolism
1546. PGC-1α-mediated regulation of mitochondrial function and physiological implications
1547. Natural products, PGC-1α, and Duchenne muscular dystrophy
1548. SnapShot: Regulation and biology of PGC-1α
1549. The role of PGC-1α and mitochondrial biogenesis in kidney diseases
1550. Microglial PGC-1α protects against ischemic brain injury by suppressing neuroinflammation
1551. Multiple levels of PGC-1α dysregulation in heart failure
1552. Upregulation of neuronal PGC-1α ameliorates cognitive impairment induced by chronic cerebral hypoperfusion
1553. PGC-1α in disease: recent renal insights into a versatile metabolic regulator
1554. Covering the Role of PGC-1α in the Nervous System
1555. A new perspective on ameliorating depression-like behaviors: suppressing neuroinflammation by upregulating PGC-1α
1556. LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling
1557. Metabolic cross-talk between skeletal muscle and adipose tissue in high-intensity interval training vs. moderate-intensity continuous training by regulation of PGC-1α
1558. Hexavalent chromium induces mitochondrial dynamics disorder in rat liver by inhibiting AMPK/PGC-1α signaling pathway
1559. Effect of High-intensity Interval Training and Accumulated Exercise on PGC-1α and SIRT3 Levels in the Skeletal Muscle of Rats and Bioinformatics Analysis
1560. … 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in rats
1561. Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity
1562. Mitophagy receptor FUNDC1 is regulated by PGC‐1α/NRF1 to fine tune mitochondrial homeostasis
1563. PGC-1α-targeted therapeutic approaches to enhance muscle recovery in aging
1564. PGC-1α affects skeletal muscle and adipose tissue development by regulating mitochondrial biogenesis
1565. Dysregulation of PGC-1α-dependent transcriptional programs in neurological and developmental disorders: therapeutic challenges and opportunities
1566. Regulation of PGC-1α expression by a GSK-3β-TFEB signaling axis in skeletal muscle
1567. Berberine protects against diabetic kidney disease via promoting PGC‐1α‐regulated mitochondrial energy homeostasis
1568. … Cognitive Impairment in an APP/PS1 transgenic mouse model of Alzheimer’s disease by relieving oxidative stress through activating the SIRT1/PGC-1α …
1569. Role of PGC-1α in the Mitochondrial NAD+ Pool in Metabolic Diseases
1570. Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1α pathway in skeletal muscle
1571. Korean Red Ginseng Improves Astrocytic Mitochondrial Function by Upregulating HO-1-Mediated AMPKα–PGC-1α–ERRα Circuit after Traumatic Brain Injury
1572. Contribution of PGC-1α to obesity-and caloric restriction-related physiological changes in white adipose tissue
1573. Activation of PGC-1α and mitochondrial biogenesis protects against prenatal hypoxic–ischemic brain injury
1574. … promotes cell survival and mitochondrial quality of bone marrow mesenchymal stem cells, and accelerates cutaneous wound healing via PGC-1α/SIRT3/HIF-1α …
1575. PI3K/AKT phosphorylation activates ERRα by upregulating PGC-1α and PGC‑1β in gallbladder cancer
1576. SIRT1 protects dopaminergic neurons in parkinson’s disease models via PGC-1α-mediated mitochondrial biogenesis
1577. The m6A methyltransferase METTL3 modifies PGC-1α mRNA promoting mitochondrial dysfunction and oxLDL-induced inflammation in monocytes
1578. Activation of GPR39 with TC-G 1008 attenuates neuroinflammation via SIRT1/PGC-1α/Nrf2 pathway post-neonatal hypoxic–ischemic injury in rats
1579. Resveratrol regulates muscle fiber type conversion via miR-22-3p and AMPK/SIRT1/PGC-1α pathway
1580. Imbalance in mitochondrial dynamics induced by low PGC-1α expression contributes to hepatocyte EMT and liver fibrosis
1581. … lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1α-dependent acyloxyacyl hydrolase …
1582. The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-PGC-1α signalling pathway
1583. Polystyrene microplastics-induced cardiotoxicity in chickens via the ROS-driven NF-κB-NLRP3-GSDMD and AMPK-PGC-1α axes
1584. PGC-1α activator ZLN005 promotes maturation of cardiomyocytes derived from human embryonic stem cells
1585. Resveratrol improves mitochondrial biogenesis function and activates PGC-1α pathway in a preclinical model of early brain injury following subarachnoid …
1586. PGC‐1α regulates myonuclear accretion after moderate endurance training
1587. MOTS-c interacts synergistically with exercise intervention to regulate PGC-1α expression, attenuate insulin resistance and enhance glucose metabolism in …
1588. Galangin Reverses H2O2-Induced Dermal Fibroblast Senescence via SIRT1-PGC-1α/Nrf2 Signaling
1589. Hengshun Aromatic Vinegar Improves Glycolipid Metabolism in Type 2 Diabetes Mellitus via Regulating PGC-1α/PGC-1β Pathway
1590. Curcumin Relieves Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior through the PGC-1α/FNDC5/BDNF Pathway
1591. Rhein Relieves Oxidative Stress in an Aβ1-42 Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis
1592. Neohesperidin enhances PGC-1α-mediated mitochondrial biogenesis and alleviates hepatic steatosis in high fat diet fed mice
1593. … sensitivity and mitochondrial respiration in skeletal muscle of type-2 diabetic mice through insulin signaling pathway and AMPK/SIRT1/PGC-1α/PPAR-γ activation
1594. PGC-1α mediates a metabolic host defense response in human airway epithelium during rhinovirus infections
1595. Atractylenolide III improves mitochondrial function and protects against ulcerative colitis by activating AMPK/SIRT1/PGC-1α
1596. Effect of endurance training and PGC-1α overexpression on calculated lactate production volume during exercise based on blood lactate concentration
1597. Pharmacologic induction of PGC‐1α stimulates fetal haemoglobin gene expression
1598. Medioresinol as a novel PGC-1α activator prevents pyroptosis of endothelial cells in ischemic stroke through PPARα-GOT1 axis
1599. The effects of different training modalities on monocarboxylate transporters MCT1 and MCT4, hypoxia inducible factor-1α (HIF-1α), and PGC-1α gene expression in rat …
1600. Looking beyond PGC-1α: emerging regulators of exercise-induced skeletal muscle mitochondrial biogenesis and their activation by dietary compounds
1601. Mitochondrial transfer from mesenchymal stem cells to macrophages restricts inflammation and alleviates kidney injury in diabetic nephropathy mice via PGC-1α …
1602. The role of PGC-1α-mediated mitochondrial biogenesis in neurons
1603. Dihydromyricetin improves mitochondrial outcomes in the liver of alcohol-fed mice via the AMPK/Sirt-1/PGC-1α signaling axis
1604. Irisin acts via the PGC-1α and BDNF pathway to improve depression-like behavior
1605. Danqi Pill Protects Against Heart Failure Post-Acute Myocardial Infarction via HIF-1α/PGC-1α Mediated Glucose Metabolism Pathway
1606. Lactate promotes metastasis of normoxic colorectal cancer stem cells through PGC-1α-mediated oxidative phosphorylation
1607. Exercise- and Cold-Induced Human PGC-1α mRNA Isoform Specific Responses
1608. Omega-3 fatty acids upregulate SIRT1/3, activate PGC-1α via deacetylation, and induce Nrf1 production in 5/6 nephrectomy rat model
1609. … neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α …
1610. Hippocampal PGC-1α-mediated positive effects on parvalbumin interneurons are required for the antidepressant effects of running exercise
1611. PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments
1612. Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1α/SIRT3 Pathway
1613. Quercetin Attenuates Diabetic Peripheral Neuropathy by Correcting Mitochondrial Abnormality via Activation of AMPK/PGC-1α Pathway in vivo and in vitro
1614. Estrogen-related receptor alpha (ERRα) is required for PGC-1α-dependent gene expression in the mouse brain
1615. Transcriptome-wide analysis of PGC-1α–binding RNAs identifies genes linked to glucagon metabolic action
1616. Roflupram exerts neuroprotection via activation of CREB/PGC‐1α signalling in experimental models of Parkinson’s disease
1617. Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease
1618. Sestrin2 overexpression attenuates osteoarthritis pain via induction of AMPK/PGC-1α-mediated mitochondrial biogenesis and suppression of neuroinflammation
1619. SIRT1/PGC-1α/PPAR-γ correlate with hypoxia-induced chemoresistance in non-small cell lung cancer
1620. … inhibits diabetes-induced atrial mitochondrial oxidative stress and improves mitochondrial biogenesis, dynamics, and function through the PPAR-γ/PGC-1α …
1621. PGC-1α inhibits the NLRP3 inflammasome via preserving mitochondrial viability to protect kidney fibrosis
1622. SIRT3-mediated SOD2 and PGC-1α contribute to chemoresistance in colorectal cancer cells
1623. Suppression of PGC-1α drives metabolic dysfunction in tgfβ2-induced emt of retinal pigment epithelial cells
1624. Acacetin ameliorates cardiac hypertrophy by activating Sirt1/AMPK/PGC-1α pathway
1625. Cardiac hypertrophy drives PGC-1α suppression associated with enhanced O-glycosylation
1626. PGC-1α senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII
1627. LncRNA HOXA-AS2 regulates microglial polarization via recruitment of PRC2 and epigenetic modification of PGC-1α expression
1628. Effect of DEHP and DnOP on mitochondrial damage and related pathways of Nrf2 and SIRT1/PGC-1α in HepG2 cells
1629. Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice
1630. Deciphering the role of PGC-1α in neurological disorders: from mitochondrial dysfunction to synaptic failure
1631. N1‑methylnicotinamide ameliorates insulin resistance in skeletal muscle of type 2 diabetic mice by activating the SIRT1/PGC-1α signaling pathway
1632. NF-κB p65 Attenuates Cardiomyocyte PGC-1α Expression in Hypoxia
1633. Glycometabolic reprogramming-mediated proangiogenic phenotype enhancement of cancer-associated fibroblasts in oral squamous cell carcinoma: role of PGC-1α …
1634. … HETE synthesis inhibition attenuates traumatic brain injury–induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC‐1α pathway: A translational …
1635. Changes in PGC‐1α/SIRT1 signaling impact on mitochondrial homeostasis in amyloid-beta peptide toxicity model
1636. CTRP3 activates the AMPK/SIRT1-PGC-1α pathway to protect mitochondrial biogenesis and functions in cerebral ischemic stroke
1637. Liraglutide Regulates Mitochondrial Quality Control System through PGC-1α in a Mouse Model of Parkinson’s Disease
1638. Novel PGC-1α/ATF5 Axis Partly Activates UPRmt and Mediates Cardioprotective Role of Tetrahydrocurcumin in Pathological Cardiac Hypertrophy
1639. PGC-1α alleviates mitochondrial dysfunction via TFEB-mediated autophagy in cisplatin-induced acute kidney injury
1640. Tannic acid provides neuroprotective effects against traumatic brain injury through the PGC-1α/Nrf2/HO-1 pathway
1641. Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model
1642. Flavonoids modulate AMPK/PGC-1α and interconnected pathways toward potential neuroprotective activities
1643. PGC-1α protects against hepatic ischemia reperfusion injury by Activating PPARα and PPARγ and regulating ROS production
1644. Comprehensive amelioration of high-fat diet-induced metabolic dysfunctions through activation of the PGC-1α pathway by probiotics treatment in mice
1645. Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non‐alcoholic fatty liver disease by up‐regulating the FGF21/PGC‐1α pathway
1646. Impairment of PGC-1α-mediated mitochondrial biogenesis precedes mitochondrial dysfunction and Alzheimer’s pathology in the 3xTg mouse model of Alzheimer’s …
1647. Ferruginol restores SIRT1-PGC-1α-mediated mitochondrial biogenesis and fatty acid oxidation for the treatment of dox-induced cardiotoxicity
1648. Hyperbaric oxygen therapy improves Parkinson’s disease by promoting mitochondrial biogenesis via the SIRT-1/PGC-1α pathway
1649. LncRNA GAS5 inhibits miR-579-3p to activate SIRT1/PGC-1α/Nrf2 signaling pathway to reduce cell pyroptosis in sepsis-associated renal injury
1650. Zearalenone promotes follicle development through activating the SIRT1/PGC-1α signaling pathway in the ovaries of weaned gilts
1651. Urolithin a protects dopaminergic neurons in experimental models of Parkinson’s disease by promoting mitochondrial biogenesis through the SIRT1/PGC-1α signaling …
1652. … insulin resistance in mice by regulating the expression of the mitochondrial-derived peptide MOTS-c and its response to exercise via APPL1–SIRT1–PGC-1α
1653. PGC‐1α protects from myocardial ischaemia‐reperfusion injury by regulating mitonuclear communication
1654. Dihydromyricetin Protects Against Gentamicin-Induced Ototoxicity via PGC-1α/SIRT3 Signaling in vitro
1655. Apelin-13 Improves Cognitive Impairment and Repairs Hippocampal Neuronal Damage by Activating PGC-1α/PPARγ Signaling
1656. DMEP induces mitochondrial damage regulated by inhibiting Nrf2 and SIRT1/PGC-1α signaling pathways in HepG2 cells
1657. PGC-1α induced mitochondrial biogenesis in stromal cells underpins mitochondrial transfer to melanoma
1658. LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/Sirt1 pathway
1659. Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1α mRNA
1660. Arginine Methylation of the PGC-1α C-Terminus Is Temperature-Dependent
1661. Ecklonia cava extracts decrease hypertension-related vascular calcification by modulating PGC-1α and SOD2
1662. MiR-22 inhibition alleviates cardiac dysfunction in doxorubicin-induced cardiomyopathy by targeting the sirt1/PGC-1α pathway
1663. PGC-1α reduces Amyloid-β deposition in Alzheimer’s disease: Effect of increased VDR expression
1664. PGC-1α participates in tumor chemoresistance by regulating glucose metabolism and mitochondrial function
1665. Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1α signaling
1666. Upregulation of PGC-1α attenuates oxygen-glucose deprivation-induced hippocampal neuronal injury
1667. Overexpression of PGC-1α influences the mitochondrial unfolded protein response (mtUPR) induced by MPP+ in human SH-SY5Y neuroblastoma cells
1668. Lactobacillus rhamnosus GG Colonization in Early Life Ameliorates Inflammaging of Offspring by Activating SIRT1/AMPK/PGC-1α Pathway
1669. Activation of PGC‐1α‐dependent mitochondrial biogenesis supports therapeutic effects of silibinin against type I diabetic periodontitis
1670. Stemness of Normal and Cancer Cells: The Influence of Methionine Needs and SIRT1/PGC-1α/PPAR-α Players
1671. Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1α/Sirt3
1672. Emerging Protective Actions of PGC-1α in Diabetic Nephropathy
1673. Hypermethylation of the gene coding for PGC-1α in peripheral blood leukocytes of patients with Parkinson’s disease
1674. Exercise training-induced PPARβ increases PGC-1α protein stability and improves insulin-induced glucose uptake in rodent muscles
1675. Salvianolic acid B protects against sepsis‑induced liver injury via activation of SIRT1/PGC-1α signaling
1676. A role for PGC-1α in transcription and excitability of neocortical and hippocampal excitatory neurons
1677. Lifelong aerobic exercise alleviates sarcopenia by activating autophagy and inhibiting protein degradation via the AMPK/PGC-1α signaling pathway
1678. PARP-1 and SIRT-1 are interacted in diabetic nephropathy by activating AMPK/PGC-1α signaling pathway
1679. PGC-1α in osteoarthritic chondrocytes: From mechanism to target of action
1680. … response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ pathway
1681. Eight weeks of high-intensity interval static strength training improves skeletal muscle atrophy and motor function in aged rats via the PGC-1α/FNDC5/UCP1 pathway
1682. PGC-1α regulates autophagy to promote fibroblast activation and tissue fibrosis
1683. Urolithin a alleviates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells through SIRT1/PGC-1α pathway
1684. Activation of LRP6 with HLY78 attenuates oxidative stress and neuronal apoptosis via GSK3β/Sirt1/PGC-1α pathway after ICH
1685. Codonopsis lanceolata and its active component Tangshenoside I ameliorate skeletal muscle atrophy via regulating the PI3K/Akt and SIRT1/PGC-1α pathways
1686. Telomeric injury by KML001 in human T cells induces mitochondrial dysfunction through the p53-PGC-1α pathway
1687. SIRT1/PGC-1α signaling activation by mangiferin attenuates cerebral hypoxia/reoxygenation injury in neuroblastoma cells
1688. Effects of Epigenetic Modification of PGC-1α by a Chemical Chaperon on Mitochondria Biogenesis and Visual Function in Retinitis Pigmentosa
1689. BMAL1 regulates mitochondrial homeostasis in renal ischaemia‐reperfusion injury by mediating the SIRT1/PGC‐1α axis
1690. Obesity caused by a high-fat diet regulates the Sirt1/PGC-1α/FNDC5/BDNF pathway to exacerbate isoflurane-induced postoperative cognitive dysfunction in older …
1691. Impacts of aerobic exercise on depression-like behaviors in chronic unpredictable mild stress mice and related factors in the AMPK/PGC-1α pathway
1692. Nrf2 Activation Attenuates Chronic Constriction Injury-Induced Neuropathic Pain via Induction of PGC-1α-Mediated Mitochondrial Biogenesis in the Spinal …
1693. Tetramethylpyrazine nitrone improves motor dysfunction and pathological manifestations by activating the PGC-1α/Nrf2/HO-1 pathway in ALS mice
1694. Trpv4 regulates Nlrp3 inflammasome via SIRT1/PGC-1α pathway in a cuprizone-induced mouse model of demyelination
1695. GATA3 induces the upregulation of UCP-1 by directly binding to PGC-1α during adipose tissue browning
1696. Melatonin elicits protective effects on OGD/R‑insulted H9c2 cells by activating PGC-1α/Nrf2 signaling
1697. … effectiveness of continuous and interval exercise preconditioning against chronic unpredictable stress: Involvement of hippocampal PGC-1α/FNDC5/BDNF pathway
1698. Perindopril improves cardiac function by enhancing the expression of SIRT3 and PGC-1α in a rat model of isoproterenol-induced cardiomyopathy
1699. Linagliptin ameliorates acetic acid-induced colitis via modulating AMPK/SIRT1/PGC-1α and JAK2/STAT3 signaling pathway in rats
1700. Ginsenoside Rd ameliorates auditory cortex injury associated with military aviation noise-induced hearing loss by activating SIRT1/PGC-1α signaling pathway
1701. PGC-1α regulates airway epithelial barrier dysfunction induced by house dust mite
1702. Sirtuin 1 alleviates microglia-induced inflammation by modulating the PGC-1α/Nrf2 pathway after traumatic brain injury in male rats
1703. Molecular basis of ventricular arrhythmogenicity in a PGC-1α deficient murine model
1704. Arsenic causes mitochondrial biogenesis obstacles by inhibiting the AMPK/PGC-1α signaling pathway and also induces apoptosis and dysregulated …
1705. Effects of bacteriophage supplement on the growth performance, microbial population, and PGC-1α and TLR4 gene expressions of broiler chickens
1706. Therapeutic potential of PGC-1α in age-related macular degeneration (AMD)–the involvement of mitochondrial quality control, autophagy, and antioxidant response
1707. IL-6 Deficiency Attenuates Skeletal Muscle Atrophy by Inhibiting Mitochondrial ROS Production through the Upregulation of PGC-1α in Septic Mice
1708. … on Neurodegeneration and Inflammation in d-Galactose-Induced Aging Mice with the Potential Mechanism Relying on AMPK/SIRT1/PGC-1α Pathway and Gut …
1709. Sulforaphane inhibits blue light–induced inflammation and apoptosis by upregulating the SIRT1/PGC-1α/Nrf2 pathway and autophagy in retinal pigment epithelial …
1710. Resveratrol increase the proportion of oxidative muscle fiber through the AdipoR1-AMPK-PGC-1α pathway in pigs
1711. Eplerenone reduces renal ischaemia/reperfusion injury by modulating Klotho, NF-κB and SIRT1/SIRT3/PGC-1α signalling pathways
1712. Alpha-Lipoic Acid Attenuates MPTP/MPP+-Induced Neurotoxicity: Roles of SIRT1-Dependent PGC-1α Signaling Pathways
1713. Melatonin improves mitochondrial function by preventing mitochondrial fission in cadmium-induced rat proximal tubular cell injury via SIRT1–PGC-1α pathway …
1714. Energy deprivation-induced AMPK activation inhibits milk synthesis by targeting PrlR and PGC-1α
1715. … of 5-heptadecylresorcinol against obesity-associated skeletal muscle dysfunction by modulating mitochondrial biogenesis via the activation of SIRT3/PGC-1α …
1716. Aspirin improves nonalcoholic fatty liver disease and atherosclerosis through regulation of the PPARδ-AMPK-PGC-1α pathway in dyslipidemic conditions
1717. Isosteviol sodium protects the cardiomyocyte response associated with the SIRT1/PGC‐1α pathway
1718. Resveratrol protects mitochondrial quantity by activating SIRT1/PGC‐1α expression during ovarian hypoxia
1719. The Acute Effects of Swimming Exercise on PGC-1α-FNDC5/Irisin-UCP1 Expression in Male C57BL/6J Mice
1720. Aldehyde dehydrogenase 2 alleviates mitochondrial dysfunction by promoting PGC-1α-mediated biogenesis in acute kidney injury
1721. PGC-1α activator–induced fatty acid oxidation in tumor-infiltrating CTLs enhances effects of PD-1 blockade therapy in lung cancer
1722. Melatonin relieves 2, 2, 4, 4-tetrabromodiphenyl ether (BDE-47)-induced apoptosis and mitochondrial dysfunction through the AMPK-Sirt1-PGC-1α axis in fish …
1723. MCU-dependent mROS generation regulates cell metabolism and cell death modulated by the AMPK/PGC-1α/SIRT3 signaling pathway
1724. PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats
1725. PGC-1α activates SIRT3 to modulate cell proliferation and glycolytic metabolism in breast cancer.
1726. Rational design, synthesis, and in vitro neuroprotective evaluation of novel glitazones for PGC-1α activation via PPAR-γ: a new therapeutic strategy for …
1727. BaZiBuShen alleviates cognitive deficits and regulates Sirt6/NRF2/HO-1 and Sirt6/P53-PGC-1α-TERT signaling pathways in aging mice
1728. Down-regulation of betatrophin enhances insulin sensitivity in type 2 diabetes mellitus through activation of the GSK-3β/PGC-1α signaling pathway
1729. Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice
1730. Potential of Telomerase in Age-Related Macular Degeneration—Involvement of Senescence, DNA Damage Response and Autophagy and a Key Role of PGC-1α
1731. Function of hesperidin alleviating inflammation and oxidative stress responses in COPD mice might be related to SIRT1/PGC-1α/NF-κB signaling axis
1732. Rosmarinic acid ameliorated cardiac dysfunction and mitochondrial injury in diabetic cardiomyopathy mice via activation of the SIRT1/PGC-1α pathway
1733. miR-373 suppresses cell proliferation and apoptosis via regulation of SIRT1/PGC-1α/NRF2 axis in pancreatic cancer
1734. Aspirin alleviates denervation-induced muscle atrophy via regulating the Sirt1/PGC-1α axis and STAT3 signaling
1735. Ferulic acid suppresses interleukin‐1β‐induced degeneration of chondrocytes isolated from patients with osteoarthritis through the SIRT1/AMPK/PGC‐1α signaling …
1736. Forty high-intensity interval training sessions blunt exercise-induced changes in the nuclear protein content of PGC-1α and p53 in human skeletal muscle
1737. Lnc RNA GUARDIN suppresses cellular senescence through a LRP 130‐PGC 1α‐FOXO 4‐p21‐dependent signaling axis
1738. Paeoniflorin ameliorates skeletal muscle atrophy in chronic kidney disease via AMPK/SIRT1/PGC-1α-mediated oxidative stress and mitochondrial dysfunction
1739. Naringin induces skeletal muscle fiber type transformation via AMPK/PGC-1α signaling pathway in mice and C2C12 myotubes
1740. miR-22-3p regulates muscle fiber-type conversion through inhibiting AMPK/SIRT1/PGC-1α pathway
1741. The mTOR/PGC-1α/SIRT3 pathway drives reductive glutamine metabolism to reduce oxidative stress caused by ISKNV in CPB cells
1742. Sirt6 opposes glycochenodeoxycholate-induced apoptosis of biliary epithelial cells through the AMPK/PGC-1α pathway
1743. Seed oil of Rosa roxburghii Tratt against non-alcoholic fatty liver disease in vivo and in vitro through PPARα/PGC-1α-mediated mitochondrial oxidative metabolism
1744. Mitigation of doxorubicin-induced cardiotoxicity by dichloroacetate: potential roles of restoration of PGC-1α/SIRT3 signaling and suppression of oxidative stress …
1745. Post‐translational regulation of PGC‐1α modulates fibrotic repair
1746. Photobiomodulation promotes repair following spinal cord injury by restoring neuronal mitochondrial bioenergetics via AMPK/PGC-1α/TFAM pathway
1747. Herba houttuyniae Extract Benefits Hyperlipidemic Mice via Activation of the AMPK/PGC-1α/Nrf2 Cascade
1748. Adult conditional knockout of PGC-1α in GABAergic neurons causes exaggerated startle reactivity, impaired short-term habituation and hyperactivity
1749. RNA-bound PGC-1α controls gene expression in liquid-like nuclear condensates
1750. PGC‐1α attenuates TNF‐α‐induced inflammatory responses in OCCM‐30 cells
1751. The effect of antecedent-conditioning high-intensity interval training on BDNF regulation through PGC-1α pathway following cerebral ischemia
1752. Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1α Signaling Pathways Mediated by the …
1753. Mitochondrial biogenesis factor PGC-1α suppresses spinal morphine tolerance by reducing mitochondrial superoxide
1754. Endoplasmic reticulum stress downregulates PGC-1α in skeletal muscle through ATF4 and an mTOR-mediated reduction of CRTC2
1755. Time-restricted feeding attenuates gluconeogenic activity through inhibition of PGC-1α expression and activity
1756. Heat‐induced changes in the expression and localisation of PGC‐1α in the mice testis
1757. … Huatan Decoction Ameliorates Myocardial Ischemia/Reperfusion Injury in Hyperlipidemic Rats via PGC-1α–PPARα and PGC-1α–NRF1–mtTFA Pathways
1758. Sea grapes extract improves blood glucose, total cholesterol, and PGC-1α in rats fed on cholesterol-and fat-enriched diet
1759. Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice
1760. Poncirin ameliorates cardiac ischemia-reperfusion injury by activating PI3K/AKT/PGC-1α signaling
1761. SIRT3 affects mitochondrial metabolic reprogramming via the AMPK–PGC‐1α axis in the development of benign prostatic hyperplasia
1762. Activation of SIRT1/PGC 1α/SIRT3 pathway by melatonin provides protection against mitochondrial dysfunction in isoproterenol induced myocardial injury
1763. Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ‐PPARγ/PGC‐1α signaling pathway
1764. Muscle PGC-1α modulates hepatic mitophagy regulation during aging
1765. Immunohistochemical analysis of PGC-1α and errα expression reveals their clinical significance in human ovarian cancer
1766. Ameliorative effect of betanin on experimental cisplatin‐induced liver injury; the novel impact of miRNA‐34a on the SIRT1/PGC‐1α signaling pathway
1767. Glucose-stimulated PGC-1α couples with CBP and Runx2 to mediate intervertebral disc degeneration through transactivation of ADAMTS4/5 in diet-induced obesity …
1768. Abdominal massage alleviates skeletal muscle insulin resistance by regulating the AMPK/SIRT1/PGC-1α signaling pathway
1769. … of Lycium barbarum Polysaccharide Combined with Aerobic Exercise Ameliorates High-Fat-Induced Nonalcoholic Steatohepatitis via AMPK/PPARα/PGC-1α …
1770. Long-term caloric restriction activates the myocardial SIRT1/AMPK/PGC-1α pathway in C57BL/6J male mice
1771. PGC-1α regulates cell proliferation and invasion via AKT/GSK-3β/β-catenin pathway in human colorectal cancer SW620 and SW480 cells
1772. Piceatannol promotes hepatic and renal AMPK/SIRT1/PGC-1α mitochondrial pathway in rats exposed to reserpine or gamma-radiation
1773. CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition
1774. Atractylenolide III from Atractylodes macrocephala Koidz promotes the activation of brown and white adipose tissue through SIRT1/PGC-1α signaling pathway
1775. Si-Miao-Yong-An decoction preserves cardiac function and regulates GLC/AMPK/NF-κB and GLC/PPARα/PGC-1α pathways in diabetic mice
1776. Sodium butyrate attenuates rotenone-induced toxicity by activation of autophagy through epigenetically regulating PGC-1α expression in PC12 cells
1777. PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis
1778. Protective effects of PGC-1α activators on ischemic stroke in a rat model of photochemically induced thrombosis
1779. The effects of Hemiscorpius lepturus induced-acute kidney injury on PGC-1α gene expression: From induction to suppression in mice
1780. Punicalagin Activates AMPK/PGC‐1α/Nrf2 Cascade in Mice: The Potential Protective Effect against Prenatal Stress
1781. ZLN005 Alleviates In Vivo and In Vitro Renal Fibrosis via PGC-1α-Mediated Mitochondrial Homeostasis
1782. The Anti-Aging Hormone Klotho Promotes Retinal Pigment Epithelium Cell Viability and Metabolism by Activating the AMPK/PGC-1α Pathway
1783. Isoliquiritigenin alleviates LPS/D-GalN-induced acute liver failure by activating the PGC-1α/Nrf2 pathway to reduce oxidative stress and inflammatory response
1784. Heat stress promotes lipid accumulation by inhibiting the AMPK-PGC-1α signaling pathway in 3T3-L1 preadipocytes
1785. PGC‐1α overexpression increases transcription factor EB nuclear localization and lysosome abundance in dystrophin‐deficient skeletal muscle
1786. PGC-1α-siRNA suppresses inflammation in substantia nigra of PD mice by inhibiting microglia
1787. Bisphenol-A mediated impaired DRP1-GFER axis and cognition restored by PGC-1α upregulation through nicotinamide in the rat brain hippocampus
1788. P2y2r deficiency ameliorates hepatic steatosis by reducing lipogenesis and enhancing fatty acid β-oxidation through ampk and PGC-1α induction in high-fat diet-fed …
1789. The PGC-1α/NRF1/miR-378a axis protects vascular smooth muscle cells from FFA-induced proliferation, migration and inflammation in atherosclerosis
1790. Dehydroepiandrosterone protects against hepatic glycolipid metabolic disorder and insulin resistance induced by high fat via activation of AMPK-PGC-1α-NRF-1 and …
1791. NRF2/PGC-1α-mediated mitochondrial biogenesis contributes to T-2 toxin-induced toxicity in human neuroblastoma SH-SY5Y cells
1792. Acute elevated resistin exacerbates mitochondrial damage and aggravates liver Steatosis through AMPK/PGC-1α signaling pathway in male NAFLD mice
1793. p53/PGC-1α‑mediated mitochondrial dysfunction promotes PC3 prostate cancer cell apoptosis
1794. PTEN regulates mitochondrial biogenesis via the AKT/GSK-3β/PGC-1α pathway in autism
1795. PGC-1α signaling increases GABA (A) receptor subunit α2 expression, GABAergic neurotransmission and anxiety-like behavior in mice
1796. … sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse …
1797. HPV E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis
1798. IL-10 ameliorates PM2. 5-induced lung injury by activating the AMPK/SIRT1/PGC-1α pathway
1799. … suppresses inflammation and blood‒brain barrier disruption in rats with vascular dementia possibly by activating the SIRT1/PGC-1α/PPARγ signaling pathway
1800. Protective effects of purple rice husk against diabetic nephropathy by modulating PGC-1α/sirt3/sod2 signaling and maintaining mitochondrial redox equilibrium in rats
1801. Depression of mitochondrial function in the rat skeletal muscle model of myofascial pain syndrome is through down-regulation of the AMPK-PGC-1α-SIRT3 axis
1802. … -selective HDAC inhibitor mocetinostat (MGCD0103) alleviates myocardial ischemia/reperfusion injury via mitochondrial protection through the HDACs/CREB/PGC-1α …
1803. Glitazones Activate PGC-1α Signaling via PPAR-γ: A Promising Strategy for Antiparkinsonism Therapeutics.
1804. YY1 inactivated transcription co-regulator PGC-1α to promote mitochondrial dysfunction of early diabetic nephropathy-associated tubulointerstitial fibrosis
1805. Elucidation of SIRT-1/PGC-1α-associated mitochondrial dysfunction and autophagy in nonalcoholic fatty liver disease
1806. Baicalin ameliorates CUMS-induced depression-like behaviors through activating AMPK/PGC-1α pathway and enhancing NIX-mediated mitophagy in mice
1807. … the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK/SIRT1/PGC-1α …
1808. Arbutin Protects Retinal Pigment Epithelium Against Oxidative Stress by Modulating SIRT1/FOXO3a/PGC-1α/β Pathway
1809. … pentaphyllum extract and Gypenoside L enhance skeletal muscle differentiation and mitochondrial metabolism by activating the PGC-1α pathway in C2C12 …
1810. Metabolic consequences of PGC-1α dysregulation in adult zebrafish muscle
1811. Srebp-1c/Fgf21/PGC-1α Axis regulated by leptin signaling in adipocytes—possible mechanism of caloric restriction-associated metabolic remodeling of white adipose …
1812. Liraglutide ameliorates gentamicin-induced acute kidney injury in rats via PGC-1α-mediated mitochondrial biogenesis: Involvement of PKA/CREB and Notch/Hes-1 …
1813. The role of PGC‐1α and metabolic signaling pathway in kidney injury following chronic administration with 3‐MCPD as a food processing contaminant
1814. PGC-1α and ERRα in patients with endometrial cancer: a translational study for predicting myometrial invasion
1815. Morroniside promotes PGC-1α-mediated cholesterol efflux in sodium palmitate or high glucose-induced mouse renal tubular epithelial cells
1816. Astragaloside IV reverses simvastatin‐induced skeletal muscle injury by activating the AMPK‐PGC‐1α signalling pathway
1817. Norisoboldine attenuates sepsis-induced acute lung injury by modulating macrophage polarization via PKM2/HIF-1α/PGC-1α pathway
1818. Melatonin-Induced PGC-1α Improves Angiogenic Potential of Mesenchymal Stem Cells in Hindlimb Ischemia
1819. Iprodione and/or chlorpyrifos exposure induced testicular toxicity in adult rats by suppression of steroidogenic genes and SIRT1/TERT/PGC-1α pathway
1820. An Association Between FNDC5, PGC-1α Genetic Variants and Obesity in Chinese Children: A Case-Control Study
1821. AMPK/PGC-1α/GLUT4-mediated effect of icariin on hyperlipidemia-induced non-alcoholic fatty liver disease and lipid metabolism disorder in mice
1822. The neuroprotective role of SIRT1/PGC-1α signaling in limb postconditioning in cerebral ischemia/reperfusion injury
1823. Rutaecarpine Promotes Adipose Thermogenesis and Protects against HFD-Induced Obesity via AMPK/PGC-1α Pathway
1824. Regulation of metabolism during hibernation in brown bears (Ursus arctos): involvement of cortisol, PGC-1α and AMPK in adipose tissue and skeletal muscle
1825. Teaghrelin Protects SH-SY5Y Cells against MPP+-Induced Neurotoxicity through Activation of AMPK/SIRT1/PGC-1α and ERK1/2 Pathways
1826. Shen Shuai Ⅱ Recipe attenuates renal fibrosis in chronic kidney disease by improving hypoxia-induced the imbalance of mitochondrial dynamics via PGC-1α …
1827. Intranasal 15d-PGJ2 ameliorates brain glucose hypometabolism via PPARγ-dependent activation of PGC-1α/GLUT4 signalling in APP/PS1 transgenic mice
1828. Activation of PGC‐1α via isoliquiritigenin‐induced downregulation of miR‐138‐5p alleviates nonalcoholic fatty liver disease
1829. PGC-1α-mediated mitochondrial quality control: molecular mechanisms and implications for heart failure
1830. Qiangji Jianli decoction promotes mitochondrial biogenesis in skeletal muscle of myasthenia gravis rats via AMPK/PGC-1α signaling pathway
1831. Resveratrol Reestablishes Mitochondrial Quality Control in Myocardial Ischemia/Reperfusion Injury through Sirt1/Sirt3-Mfn2-Parkin-PGC-1α Pathway
1832. … improves insulin sensitivity and promotes adipose thermogenesis in diet-induced obese mice associated with activation of PGC-1α-FNDC5/irisin pathway
1833. Shen Qi Li Xin formula improves chronic heart failure through balancing mitochondrial fission and fusion via upregulation of PGC-1α
1834. Insulin injections inhibits PTZ-induced mitochondrial dysfunction, oxidative stress and neurological deficits via the SIRT1/PGC-1α/SIRT3 pathway
1835. PGC-1α controls epidermal stem cell fate and skin repair by sustaining NAD+ homeostasis during aging
1836. Graded reductions in pre‐exercise glycogen concentration do not augment exercise‐induced nuclear AMPK and PGC‐1α protein content in human muscle
1837. SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/PGC-1α positive feedback loop
1838. Metabolomic analysis on blood of transgenic mice overexpressing PGC-1α in skeletal muscle
1839. … phenolic extract confers protective effects against alcoholic liver disease in mice by alleviating mitochondrial dysfunction via the PGC-1α-TFAM pathway mediated by …
1840. Effect of selenium supplementation on expression of SIRT1 and PGC-1α genes in ulcerative colitis patients: a double blind randomized clinical trial
1841. … Antioxidative Capability and Promotes Mitochondrial Biogenesis in D-Galactose-Induced Aging Mice by Increasing Nrf2 and PGC-1α through the cAMP …
1842. PGC-1α regulate critical period plasticity via gene× environment interaction in the developmental trajectory to schizophrenia
1843. PGC-1α Is a Master Regulator of Mitochondrial Lifecycle and ROS Stress Response
1844. Deoxyarbutin attenuates severe acute pancreatitis via the HtrA2/PGC-1α pathway
1845. PGC-1α promotes mitochondrial respiration and biogenesis during the differentiation of hiPSCs into cardiomyocytes
1846. PGC-1α in mediating mitochondrial biogenesis and intestinal epithelial differentiation promoted by purple potato extract
1847. … protective effects of α-Mangostin attenuate sodium iodate-induced cytotoxicity and oxidative injury via mediating SIRT-3 inactivation via the PI3K/AKT/PGC-1α …
1848. Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia …
1849. Cross-talk between TRPC-1, mTOR, PGC-1α and PPARδ in the dystrophic muscle cells treated with tempol
1850. Effect of feeding regimen on meat quality, MyHC isoforms, AMPK, and PGC‐1α genes expression in the biceps femoris muscle of Mongolia sheep
1851. Dual Role of Phenyl Amides from Hempseed on BACE 1, PPARγ, and PGC-1α in N2a-APP Cells
1852. Jieduquyuziyin Prescription alleviates hepatic gluconeogenesis via PI3K/Akt/PGC-1α pathway in glucocorticoid-induced MRL/lpr mice
1853. The effect of Crocin on TFAM and PGC-1α expression and Catalase and Superoxide dismutase activities following cholestasis-induced neuroinflammation in the …
1854. Protective effect of Jiang Tang Xiao Ke Granules against skeletal muscle IR via activation of the AMPK/SIRT1/PGC-1α signaling pathway
1855. A novel gravity-induced blood flow restriction model augments ACC phosphorylation and PGC-1α mRNA in human skeletal muscle following aerobic exercise: a …
1856. Betulinic acid decreases lipid accumulation in adipogenesis-induced human mesenchymal stem cells with upregulation of PGC-1α and UCP-1 and post …
1857. … -survival properties of safinamide against methamphetamine-induced neurodegeneration: Hypothetic possible role of BDNF/TrkB/PGC-1α signaling pathway and …
1858. Glucagon Promotes Gluconeogenesis through the GCGR/PKA/CREB/PGC-1α Pathway in Hepatocytes of the Japanese Flounder Paralichthys olivaceus
1859. Association of Irisin/FNDC5 with ERRα and PGC-1α Expression in NSCLC
1860. Faster lipid β‐oxidation rate by acetyl‐CoA carboxylase 2 inhibition alleviates high‐glucose‐induced insulin resistance via SIRT1/PGC‐1α in human podocytes
1861. Constitutive PGC-1α overexpression in skeletal muscle does not contribute to exercise-induced neurogenesis
1862. Maternal zinc alleviates tert-butyl hydroperoxide-induced mitochondrial oxidative stress on embryonic development involving the activation of Nrf2/PGC-1α …
1863. Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury
1864. Reactive Oxygen Species Control Osteoblast Apoptosis through SIRT1/PGC-1α/P53Lys382 Signaling, Mediating the Onset of Cd-Induced Osteoporosis
1865. Epithelial SMYD5 Exaggerates IBD by Down-regulating Mitochondrial Functions via Post-Translational Control of PGC-1α Stability
1866. Rosmarinic acid protects against lipopolysaccharide‐induced cardiac dysfunction via activating Sirt1/PGC‐1α pathway to alleviate mitochondrial impairment
1867. Effect of cholestasis and NeuroAid treatment on the expression of Bax, Bcl-2, PGC-1α and Tfam genes involved in apoptosis and mitochondrial biogenesis in the …
1868. Cardiomyocyte-restricted high-mobility group box 1 (HMGB1) deletion leads to small heart and glycolipid metabolic disorder through GR/PGC-1α signalling
1869. Zinc is essential for the transcription function of the PGC-1α/Nrf2 signaling pathway in human primary endometrial stromal cells
1870. Sp1 Inhibits PGC-1α via HDAC2-Catalyzed Histone Deacetylation in Chronic Constriction Injury-Induced Neuropathic Pain
1871. Resveratrol attenuates hyperoxia lung injury in neonatal rats by activating SIRT1/PGC-1α signaling pathway
1872. Celastrol regulates bone marrow mesenchymal stem cell fate and bone-fat balance in osteoporosis and skeletal aging by inducing PGC-1α signaling
1873. Studies on the mechanism of energy metabolism via AMPK/PGC‐1α signaling pathway induced by compatibility of Ligusticum chuanxiong Hort and Gastrodia
1874. Role of Estrogen-Related Receptor γ and PGC-1α/SIRT3 Pathway in Early Brain Injury After Subarachnoid Hemorrhage
1875. Role of swimming on muscle PGC-1α, FNDC5 mRNA, and assessment of serum omentin, adropin, and irisin in high carbohydrate high fat (HCHF) diet …
1876. SESN2 prevents the slow-to-fast myofiber shift in denervated atrophy via AMPK/PGC-1α pathway
1877. The expression of liver metabolic enzymes ampkα1, ampkα2, and PGC-1α due to exercise in Type-2 diabetes mellitus rat model
1878. Bisphenol A exposure induces metastatic aggression in low metastatic MCF-7 cells via PGC-1α mediated mitochondrial biogenesis and epithelial-mesenchymal …
1879. Antifatigue effects of anshenyizhi compound in acute excise‐treated mouse via modulation of AMPK/PGC‐1α‐related energy metabolism and Nrf2/ARE‐mediated …
1880. Alzheimer’s and Parkinson’s brain tissues have reduced expression of genes for mtDNA OXPHOS Proteins, mitobiogenesis regulator PGC-1α protein and mtRNA …
1881. Dexmedetomidine Exerts Renal Protective Effect by Regulating the PGC-1α/STAT1/IRF-1 Axis
1882. Phosphocreatine promotes osteoblastic activities in H2O2-induced MC3T3-E1 cells by regulating SIRT1/FOXO1/PGC-1α signaling pathway
1883. PGC-1α Regulates Cell Proliferation, Migration, and Invasion by Modulating Leucyl-tRNA Synthetase 1 Expression in Human Colorectal Cancer Cells
1884. Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover
1885. Placental insulin/IGF-1 signaling, PGC-1α, and inflammatory pathways are associated with metabolic outcomes at 4–6 years of age: the ECHO healthy start cohort
1886. Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling
1887. The anti-fatigue effect of the Auxis thazard oligopeptide via modulation of the AMPK/PGC-1α pathway in mice
1888. Remote ischemic preconditioning protects against spinal cord ischemia–reperfusion injury in mice by activating NMDAR/AMPK/PGC-1α/SIRT3 signaling
1889. Translocator Protein (TSPO) Alleviates Neuropathic Pain by Activating Spinal Autophagy and Nuclear SIRT1/PGC-1α Signaling in a Rat L5 SNL Model
1890. Periplaneta americana extract ameliorates lipopolysaccharide‑induced liver injury by improving mitochondrial dysfunction via the AMPK/PGC-1α signaling …
1891. Promotion of mitochondrial biogenesis via the regulation of PARIS and PGC-1α by parkin as a mechanism of neuroprotection by carnosic acid
1892. Matrine counteracts obesity in mice via inducing adipose thermogenesis by activating HSF1/PGC-1α axis
1893. PGC-1α overexpression is not sufficient to mitigate cancer cachexia in either male or female mice
1894. Positive regulation of TFEB and mitophagy by PGC-1α to alleviate LPS-induced acute lung injury in rats
1895. The effect of high-intensity interval training on the expression levels of PGC-1α and SIRT3 proteins and aging index of slow-twitch and fast-twitch of healthy male rats
1896. Survival pathways of HIF-deficient tumour cells: TCA inhibition, peroxisomal fatty acid oxidation activation and an AMPK-PGC-1α hypoxia sensor
1897. von Hippel-Lindau-targeting microRNA-143–3p attenuates mitochondrial abnormality via AMPK/PGC-1α axis in Parkinson’s disease
1898. RORA alleviates LPS-induced apoptosis of renal epithelial cells by promoting PGC-1α transcription
1899. NT-PGC-1α deficiency attenuates high-fat diet-induced obesity by modulating food intake, fecal fat excretion and intestinal fat absorption
1900. Naringenin promoted spinal microglia M2 polarization in rat model of cancer-induced bone pain via regulating AMPK/PGC-1α signaling axis
1901. Citrus hassaku Extract Powder Increases Mitochondrial Content and Oxidative Muscle Fibers by Upregulation of PGC-1α in Skeletal Muscle
1902. Genetic Variants of VDR and PGC-1α Are Not Associated with the Risk of Endometriosis in Indian Women
1903. Nanoparticle endothelial delivery of PGC-1α attenuates hypoxia-induced pulmonary hypertension by attenuating EndoMT-caused vascular wall remodeling
1904. Hepatic Gadd45β promotes hyperglycemia and glucose intolerance through DNA demethylation of PGC-1α
1905. TLR4 knockout upregulates the expression of Mfn2 and PGC-1α in a high-fat diet and ischemia-reperfusion mice model of liver injury
1906. Effect of 12-wk Training in Ovariectomised Rats on PGC-1α, NRF-1 and Energy Substrates
1907. Luteolin increases slow muscle fibers via FLCN-AMPK-PGC-1α signaling pathway
1908. Hypoxia preconditioning improves structure and function of astrocytes mitochondria via PGC-1α/HIF signal
1909. … 4B activation exacerbates pulmonary hypertension induced by intermittent hypoxia by regulating mitochondrial injury and cAMP/PKA/p-CREB/PGC-1α …
1910. Melatonin attenuates bisphenol A-induced colon injury by dual targeting mitochondrial dynamics and Nrf2 antioxidant system via activation of SIRT1/PGC-1α signaling …
1911. AMPK Regulates DNA Methylation of PGC-1α and Myogenic Differentiation in Human Mesenchymal Stem Cells
1912. PGC-1α/NRF1-dependent cardiac mitochondrial biogenesis: A druggable pathway of calycosin against triptolide cardiotoxicity
1913. Exchange protein directly activated by cAMP (Epac) 1 plays an essential role in stress-induced exercise capacity by regulating PGC-1α and fatty acid metabolism in …
1914. Design and Development of Novel Glitazones for Activation of PGC-1α Signaling Via PPAR-γ Agonism: A Promising Therapeutic Approach against Parkinson’s …
1915. Activating PGC-1α-mediated signaling cascades in the aorta contributes to the amelioration of vascular senescence and atherosclerosis by 2, 3, 4′, 5 …
1916. Simvastatin Impairs Glucose Homeostasis in Mice Depending on PGC-1α Skeletal Muscle Expression
1917. N-acetylserotonin inhibits oxidized mitochondrial DNA-induced neuroinflammation by activating the AMPK/PGC-1α/TFAM pathway in neonatal hypoxic-ischemic brain …
1918. Training protocols differently affect AMPK–PGC-1α signaling pathway and redox state in trout muscle
1919. Effects of Simvastatin on Lipid Metabolism in Wild-Type Mice and Mice with Muscle PGC-1α Overexpression
1920. DT-010 Exerts Cardioprotective Effects by Regulating the Crosstalk between the AMPK/PGC-1α Pathway and ERp57
1921. PPARβ/δ Agonism with GW501516 Increases Myotube PGC-1α Content and Reduces BCAA Media Content Independent of Changes in BCAA Catabolic …
1922. PGC-1α haploinsufficiency promotes pain chronification after burn injury
1923. Phthalate induces mitochondrial injury in cerebellum through Sirt1-PGC-1α and PINK1/Parkin-mediated signal pathways
1924. Indirubin-3′-oxime (IDR3O) inhibits proliferation of osteosarcoma cells in vitro and tumor growth in vivo through AMPK-activation and PGC-1α/TFAM up-regulation
1925. Activation of CB1R-Dependent PGC-1α Is Involved in the Improved Mitochondrial Biogenesis Induced by Electroacupuncture Pretreatment
1926. Nr2f2 Overexpression Aggravates Ferroptosis and Mitochondrial Dysfunction by Regulating the PGC-1α Signaling in Diabetes-Induced Heart Failure Mice
1927. Gain-of-Function p53N236S Mutation Drives the Bypassing of HRasV12-Induced Cellular Senescence via PGC–1α
1928. Alpha‐Asarone modulates kynurenine disposal in muscle and mediates resilience to stress‐induced depression via PGC‐1α induction
1929. Hepatic PGC-1α has minor regulatory effect on the liver transcriptome and metabolome during high fat high fructose diet and exercise training
1930. Correction to: YY1 inactivated transcription co‐regulator PGC‐1α to promote mitochondrial dysfunction of early diabetic nephropathy‐associated tubulointerstitial …
1931. PGC-1α in the myofibers regulates the balance between myogenic and adipogenic progenitors affecting muscle regeneration
1932. Empagliflozin attenuates doxorubicin-induced cardiotoxicity by activating AMPK/SIRT-1/PGC-1α-mediated mitochondrial biogenesis
1933. PGC-1α and MEF2 Regulate the Transcription of the Carnitine Transporter OCTN2 Gene in C2C12 Cells and in Mouse Skeletal Muscle
1934. Magnolol alleviates IL-1β-induced dysfunction of chondrocytes through repression of SIRT1/AMPK/PGC-1α signaling pathway
1935. D-allulose ameliorates adiposity through the AMPK-SIRT1-PGC-1α pathway in HFD-induced SD rats
1936. PPAR-γ Activation Alleviates Osteoarthritis through Both the Nrf2/NLRP3 and PGC-1α/Δψm Pathways by Inhibiting Pyroptosis
1937. Quercetin Reprograms Immunometabolism of Macrophages via the SIRT1/PGC-1α Signaling Pathway to Ameliorate Lipopolysaccharide-Induced Oxidative …
1938. Aspirin alleviates cisplatin-induced acute kidney injury through the AMPK-PGC-1α signaling pathway
1939. Conditional deletion of PGC-1α results in energetic and functional defects in NK cells
1940. Resveratrol Improves Paclitaxel-Induced Cognitive Impairment in Mice by Activating SIRT1/PGC-1α Pathway to Regulate Neuronal State and Microglia Cell …
1941. Oridonin ameliorates acetaminophen‐induced acute liver injury through ATF4/PGC‐1α pathway
1942. Garcinol protects SH‐SY5Y cells against MPP+‐induced cell death by activating DJ‐1/SIRT1 and PGC‐1α mediated antioxidant pathway in sequential stimulation of p …
1943. PGC-1α gene transfer restores adhesion and reendothelialization of endothelial progenitor cells from patients with hypertension
1944. Inhibition of the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α)/sirtuin 3 (SIRT3) pathway aggravates oxidative stress after …
1945. Baoyuan Jiedu decoction alleviates cancer-induced myotube atrophy by regulating mitochondrial dynamics through p38 MAPK/PGC-1α signaling pathway
1946. PGC-1α deficiency reveals sex-specific links between cardiac energy metabolism and EC-coupling during development of heart failure in mice
1947. An original amino acid formula favours in vitro corneal epithelial wound healing by promoting Fn1, ITGB1, and PGC-1α expression
1948. Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) overexpression alleviates endoplasmic reticulum stress after acute kidney injury
1949. SIRT1/PGC-1α is involved in arsenic-induced male reproductive damage through mitochondrial dysfunction, which is blocked by the antioxidative effect of zinc
1950. QKI 6 ameliorates CIRI through promoting synthesis of triglyceride in neuron and inhibiting neuronal apoptosis associated with SIRT1‐PPARγ‐PGC‐1α axis
1951. The adverse effects of hypoxia on hiHep functions via HIF-1α/PGC-1α axis are alleviated by PFDC emulsion
1952. Dihydromyricetin ameliorates diet-induced obesity and promotes browning of white adipose tissue by upregulating IRF4/PGC-1α
1953. Anti-TWEAK antibody alleviates renal interstitial fibrosis by increasing PGC-1α expression in lupus nephritis
1954. Ameliorative effect of Lactobacillus rhamnosus GG on acetaminophen-induced hepatotoxicity via PKC/Nrf2/PGC-1α pathway
1955. Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
1956. SS31 Confers Cerebral Protection by Reversing Mitochondrial Dysfunction in Early Brain Injury Following Subarachnoid Hemorrhage, via the Nrf2-and PGC-1α …
1957. Diet Control and Swimming Exercise Ameliorate HFD-Induced Cognitive Impairment Related to the SIRT1-NF-κB/PGC-1α Pathways in ApoE-/- Mice
1958. Role of PGC-1α mediated synaptic plasticity, mitochondrial function, and neuroinflammation in the antidepressant effect of Zi-Shui-Qing-Gan-Yin
1959. Genetic ablation of aldehyde reductase (Akr1a) augments exercise endurance in mice via activation of the PGC-1α-involved pathway
1960. PPRC1, but not PGC-1α, levels directly correlate with expression of mitochondrial proteins in human dermal fibroblasts
1961. … /pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α …
1962. Knockdown of Sirt1 Gene in Mice Results in Lipid Accumulation in the Liver Mediated via PGC-1α-Induced Mitochondrial Dysfunction and Oxidative Stress
1963. Effects of Treadmill Exercise on the Expression Level of BAX, BAD, BCL-2, BCL-XL, TFAM, and PGC-1α in the Hippocampus of Thimerosal-Treated Rats
1964. Salvianolic acid A promotes mitochondrial biogenesis and function via regulating the AMPK/PGC-1α signaling pathway in HUVECs
1965. β1 adrenoceptor antibodies induce myocardial apoptosis via inhibiting PGC-1α-related pathway
1966. Oxidative stress and mitochondrial damage in dry age-related macular degeneration like NFE2L2/PGC-1α-/-mouse model evoke complement component C5a …
1967. Icariside II, a Naturally Occurring SIRT3 Agonist, Protects against Myocardial Infarction through the AMPK/PGC-1α/Apoptosis Signaling Pathway
1968. 17beta-estradiol alleviates contusion-induced skeletal muscle injury by decreasing oxidative stress via SIRT1/PGC-1α/Nrf2 pathway
1969. Lipoxin A4 attenuated dexamethasone-induced muscle atrophy via activation of PGC-1α/Nrf2/TFAM pathway
1970. Cordycepin exhibits anti-fatigue effect via activating TIGAR/SIRT1/PGC-1α signaling pathway
1971. SIRT3 ameliorates polycystic ovary syndrome through FOXO1/PGC-1α signaling pathway
1972. Basolateral amygdala SIRT1/PGC-1α mitochondrial biogenesis pathway mediates morphine withdrawal-associated anxiety in mice
1973. Pharmacological Activation of Rev-erbα Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1α Signaling Pathway
1974. The role of PGC-1α in digestive system malignant tumours
1975. Dietary L-arginine supplementation influences the muscle fiber characteristics and meat quality of Mongolian sheep through the NO/AMPK/PGC-1α pathway
1976. VGLL3 confers slow-twitch muscle differentiation via PGC-1α expression in C2C12 myocytes
1977. … Medicine Formula: Yinhuo Decoction Antagonizes the Damage of Corticosterone to PC12 Cells and Improves Depression by Regulating the SIRT1/PGC-1α …
1978. The effect of crocin on cholestasis-induced spatial memory impairment with respect to the expression level of TFAM and PGC-1α and activity of catalase and …
1979. Downregulation of miR-761 ameliorates radiation-induced pulmonary fibrosis by regulating PGC-1α
1980. Low-Nutrient Environment-Induced Changes in Inflammation, Cell Proliferation, and PGC-1α Expression in Stromal Cells with Ovarian Endometriosis
1981. San-Huang-Tang protects obesity/diabetes induced NAFLD by upregulating PGC-1α/PEPCK signaling in obese and galr1 knockout mice models
1982. … (the dried rhizome of Acorus tatarinowii Schott) prevents hydrogen peroxide-induced cell injury in PC12 cells: a signaling triggered by CREB/PGC-1α …
1983. ∆nFGF1 Protects β-Cells against High Glucose-Induced Apoptosis via the AMPK/SIRT1/PGC-1α Axis
1984. Cholecystokinin Octapeptide Promotes ANP Secretion through Activation of NOX4–PGC-1α–PPARα/PPARγ Signaling in Isolated Beating Rat Atria
1985. Changes in PGC-1α-Dependent Mitochondrial Biogenesis Are Associated with Inflexible Hepatic Energy Metabolism in the Offspring Born to Dexamethasone-Treated …
1986. Exposure to dipentyl phthalate in utero disrupts the adrenal cortex function of adult male rats by inhibiting SIRT1/PGC‐1α and inducing AMPK phosphorylation
1987. Role of PGC‐1α in fiber type conversion in the palatopharyngeus muscle of OSA patients
1988. Epigenetic control of mitochondrial fission enables hepatic stellate cells activation in liver fibrosis via PGC-1α-Drp1 pathway
1989. Beneficial effects of quercetin on vincristine‐induced liver injury in rats: Modulating the levels of Nrf2/HO‐1, NF‐kB/STAT3, and SIRT1/PGC‐1α
1990. Research progress of effect and mechanism of PGC-1α in cardiovascular diseases
1991. … a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and Silybum marianum (Silymarin) for Recovering Metabolic Homeostasis via PGC-1α, Il-6, and …
1992. Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential
1993. Activation of AMPK-PGC-1α pathway ameliorates peritoneal dialysis related peritoneal fibrosis in mice by enhancing mitochondrial biogenesis
1994. Mitochondrial energy metabolism is downregulated in repeated implantation failure patients related to alteration of PGC‐1α acetylation level
1995. Perilipin Isoforms and PGC-1α Are Regulated Differentially in Rat Heart during Pregnancy-Induced Physiological Cardiac Hypertrophy
1996. Effect of icariin on the H2O2-induced proliferation of mouse airway smooth muscle cells through miR-138-5p regulating SIRT1/AMPK/PGC-1α axis
1997. Nesfatin-1 alleviates hyperoxia-induced lung injury in newborn mice by inhibiting oxidative stress through regulating SIRT1/PGC-1α pathway
1998. Measuring PGC-1α and Its Acetylation Status in Mouse Primary Myotubes
1999. Hepatic PGC-1α is not essential for fasting-induced cytochrome p450 regulation in mouse liver
2000. SWI/SNF complex subunit BAF60a represses hepatic ureagenesis through a crosstalk between YB-1 and PGC-1α
2001. Effect of eight weeks of aerobic progressive training with capsaicin on changes in PGC-1α and UPC-1 expression in visceral adipose tissue of obese rats with …
2002. Chronic voluntary wheel running exercise ameliorates metabolic dysfunction via PGC-1α expression independently of FNDC5/irisin pathway in high fat diet …
2003. Changes in Serum Levels and Gene Expression of PGC-1α in The Cardiac Muscle of Diabetic Rats: The Effect of Dichloroacetate and Endurance Training
2004. Stiffer-Matrix-Induced PGC-1α Upregulation Enhanced Mitochondrial Biogenesis and Oxidative Stress Resistance in Non-small Cell Lung Cancer
2005. Effects of a yeast cell wall product on the performance of broiler chickens and PGC-1α, TLR4, IL-10 and PPARγ genes expression
2006. Salvianolic Acid B Alleviates Myocardial Ischemia Injury by Suppressing NLRP3 Inflammasome Activation via SIRT1-AMPK-PGC-1α Signaling Pathway
2007. β1-Adrenoceptor antibodies induce PPCM via inhibition of PGC-1α related pathway
2008. Hydrogen sulfide alleviates heart failure with preserved ejection fraction in mice by targeting mitochondrial abnormalities via PGC-1α
2009. Cumulative effect of cardiovascular risk factors on regulation of AMPK/SIRT1-PGC-1α-SIRT3 pathway in the human erectile tissue
2010. SUMOylation of SIRT1 activating PGC-1α/PPARα pathway mediates the protective effect of LncRNA-MHRT in cardiac hypertrophy
2011. High expressions of the cytoglobin and PGC-1α genes during the tissue regeneration of house gecko (Hemidactylus platyurus) tails
2012. Advanced Glycation End Products Induced Mitochondrial Dysfunction of Chondrocytes through Repression of AMPKα-SIRT1-PGC-1α Pathway
2013. PGC-1α Promotes Phosphorylation, Inflammation, and Apoptosis in H9c2 Cells During the Early Stage of Lipopolysaccharide Induction
2014. Effects of Hypoxic and Normoxic Training in Altitude on HIF-1α and PGC-1α Levels in Elite Endurance Runners
2015. The master energy homeostasis regulator PGC-1α couples transcriptional co-activation and mRNA nuclear export
2016. Nucleolin protects cardiomyocytes by upregulating PGC-1α and promoting mitochondrial biogenesis in LPS-induced myocardial injury
2017. Mitoprotective effect of mesenchymal stem cells-derived conditioned medium in myocardial reperfusion injury of aged rats: role of SIRT-1/PGC-1α/NRF-2 network
2018. Maternal nicotine exposure impairs brown adipose tissue via AMPK-SIRT1-PGC-1α signals in male offspring
2019. Bovine-derived MFG-E8 alleviating mitochondrial dysfunction via Akt/Sirt1/PGC-1α and MAPK/ERK signaling cascades
2020. Protein kinase C beta relieves autism‐like behavior in EN2 knockout mice via upregulation of the FTO/PGC‐1α/UCP1 axis
2021. Plin5 inhibits proliferation and migration of vascular smooth muscle cell through interacting with PGC-1α following vascular injury
2022. S-nitrosylated PARIS Leads to the Sequestration of PGC-1α into Insoluble Deposits in Parkinson’s Disease Model
2023. San-Huang-Chai-Zhu Formula Ameliorates Liver Injury in Intrahepatic Cholestasis through Suppressing SIRT1/PGC-1α-Regulated Mitochondrial Oxidative …
2024. NRG1/ErbB2 axis regulated mitochondrial function and antioxidant enzymes of neural stem cells in the cochlear nucleus partially through PGC-1α
2025. Methyltransferase SMYD5 Exaggerates IBD by Downregulating Mitochondrial Functions via Post-translational Control of PGC-1α Stability
2026. Adenosine receptor A1 enhanced mitochondrial biogenesis and exerted neuroprotection after cerebral ischemia through PGC-1α
2027. [Corrigendum] miR‑29b overexpression induces cochlear hair cell apoptosis through the regulation of SIRT1/PGC-1α signaling: Implications for age‑related hearing …
2028. Metabolic reprogramming via an engineered PGC-1α improves human chimeric antigen receptor T-cell therapy against solid tumors
2029. Characterization of Age-dependent Behavior Deficits in the PGC-1α Knockout Mouse, in Relevance to the Parkinson’s Disease Model
2030. Potential Role of Peroxisome Proliferator-activated Receptor Gamma Coactivator-1 Alpha (PGC-1α) Gene Polymorphism in Patients with Type 2 Diabetes Mellitus
2031. The β3 adrenergic receptor agonist CL316243 ameliorates the metabolic abnormalities of high-fat diet-fed rats by activating AMPK/PGC-1α signaling in skeletal …
2032. … thymol ester inhibits melanogenesis in normal human melanocytes and 3D human epidermal equivalents via the PGC-1α-independent PPARγ partial agonism
2033. Perampanel stimulates mitochondrial biogenesis in neuronal cells through activation of the SIRT1/PGC-1α signaling pathway
2034. Silent information regulator 1 ameliorates oxidative stress injury via PGC-1α/PPARγ-Nrf2 pathway after ischemic stroke in rat
2035. PV-specific loss of the transcriptional coactivator PGC-1α slows down the evolution of epileptic activity in an acute ictogenic model
2036. Insufficient sleep disrupts glucose metabolism during pregnancy by inhibiting PGC-1α
2037. Morinda officinalis polysaccharide attenuates osteoporosis in rats underwent bilateral ovariectomy by suppressing the PGC-1α/PPARγ pathway
2038. FGF19 improves sevoflurane-induced cognitive dysfunction in rats through the PGC-1α/BDNF/FNDC5 pathway
2039. PGC-1α differentially regulates the mRNA expression profiles of genes related to myofiber type specificity in chicken
2040. Protective effects of PGC-1α on the blood brain barrier after acute kidney injury
2041. Calorie Restriction Combined with High-Intensity Interval Training Promotes Browning of White Adipose Tissue by Activating the PPARγ/PGC-1α/UCP1 …
2042. Aerobic exercise ameliorates myocardial ischemia/reperfusion injury and thrombosis of diabetic rats via activation of AMPK/Sirt1/PGC-1α pathway.
2043. PGC-1α attenuates the oxidative stress-induced impaired osteogenesis and angiogenesis regulation effects of mesenchymal stem cells in the presence of …
2044. Stimulating the sir2-PGC-1α axis rescues exercise capacity and mitochondrial respiration in Drosophila tafazzin mutants
2045. HypERlnc attenuates angiotensin II‐induced cardiomyocyte hypertrophy via promoting SIRT1 SUMOylation‐mediated activation of PGC‐1α/PPARα pathway in AC16 …
2046. PGC-1α is an exercise-responsive regulator of myosteatosis in older individuals
2047. Anti-oxidant effect of metformin through AMPK/SIRT1/PGC-1α/SIRT3–independent GPx1 expression in the heart of mice with endometriosis
2048. PGC 1α-Mediates Mitochondrial Damage in the Liver by Inhibiting the Mitochondrial Respiratory Chain as a Non-cholinergic Mechanism of Repeated Low …
2049. Metabolically flexible CAR T cells (mfCAR-T), with constitutive expression of PGC-1α resistant to post translational modifications, exhibit superior survival and …
2050. Effects of NRF-1 and PGC-1α cooperation on HIF-1α and rat cardiomyocyte apoptosis under hypoxia
2051. Protective effects of 6-Gingerol on cardiotoxicity induced by arsenic trioxide through AMPK/SIRT1/PGC-1α signaling pathway
2052. Edaravone prevents high glucose-induced injury in retinal Müller cells through thioredoxin1 and the PGC-1α/NRF1/TFAM pathway
2053. Effects of quercetin on hepatic fibroblast growth factor-21 (FGF-21) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) levels in rats …
2054. Tryptophan alleviates lipopolysaccharide-induced muscle fiber type transformation from type I to II and modulates Sirt1/AMPK/PGC-1α signaling pathway in pigs
2055. The effect of aerobic exercise training on hypoxia condition through PGC-1α angiogenesis signaling pathway in heart tissue of male westar rats
2056. The effect of neuroaid (MLC901) on cholestasis-induced spatial memory impairment with respect to the expression of BAX, BCL-2, BAD, PGC-1α and TFAM genes in …
2057. Curcumin relieves corticosterone‐induced behaviour deficits via PGC‐1α‐mediated mitochondrial biogenesis and mitophagy
2058. … : Isovitexin-Mediated Regulation of Microglial Polarization in Lipopolysaccharide-Induced Neuroinflammation via Activation of the CaMKKβ/AMPK-PGC-1α Signaling …
2059. Overexpression of PGC-1α reduces inflammation and protects against focal cerebral ischaemia/reperfusion injury
2060. Curcumin attenuates isoniazid‐induced hepatotoxicity by upregulating the SIRT1/PGC‐1α/NRF1 pathway
2061. Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1α -/- Mouse Model Evoke Complement Component C5a …
2062. Mechanism of Zexie Decoction in improvement of nonalcoholic fatty liver disease based on LKB1/AMPK/PGC-1α pathway
2063. Garcinol Promotes the Formation of Slow-Twitch Muscle Fibers by Inhibiting p300-Dependent Acetylation of PGC-1α
2064. Correction: Kavain Reduces Porphyromonas gingivalis–Induced Adipocyte Inflammation: Role of PGC-1α Signaling
2065. Bioactive Oligopeptides from Ginseng (Panax ginseng Meyer) Suppress Oxidative Stress-Induced Senescence in Fibroblasts via NAD+/SIRT1/PGC-1α …
2066. Effect of electroacupuncture invention on activities of PGC-1α/Irisin (FNDC5)/BDNF signaling in cerebral cortex, hippocampus and muscles in focal cerebral ischemic …
2067. Effect of Endurance Training and MitoQ on Expression of PGC-1α, ERR-α, MCAD, and CPT-1α Genes in Skeletal Muscle of Male Wistar Rats
2068. Inhibition of osteosarcoma cell proliferation in vitro and tumor growth in vivo in mice model by alstonine through AMPK-activation and PGC-1α/TFAM up-regulation
2069. Berberine Ameliorates Cognitive Disorder via GSK3β/PGC-1α Signaling in APP/PS1 Mice
2070. Relationship Between Myocardial Injury and Expression of PGC-1α and Its Coactivators in Chronic Keshan Disease
2071. miR‑382 inhibits breast cancer progression and metastasis by affecting the M2 polarization of tumor‑associated macrophages by targeting PGC-1α
2072. … effect of eight weeks of high-intensity interval training vs. continuous training on serum Irisin levels and expression of skeletal muscle PGC-1α gene in male …
2073. Human papilloma virus E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis
2074. The acute effects of high intensity interval training (HIIIT) on PGC-1α and FNDC5 genes expression in diabetic rats
2075. Down-regulation of SIRT1 and PGC-1α expression caused by hyperoxia induces mitochondrial dysfunction in human alveolar epithelial cells
2076. Angiotensin II-mediated improvement of renal mitochondrial function via the AMPK/PGC-1α/NRF-2 pathway is superior to norepinephrine in a rat model of …
2077. The effect of eight weeks of aerobic exercise with moderate and high intensities on serum irisin and PGC-1α protein levels in obese male Wistar rats
2078. Free fatty acid-induced miR-22 inhibits gluconeogenesis via SIRT-1-mediated PGC-1α expression in nonalcoholic fatty liver disease
2079. The effects of Formoterol in preventing adipogenesis and obesity are mediated by PPARγ/C/EBPα axis and AMPK/PGC-1α pathway
2080. PGC-1α: a target for neurodegenerative disorders
2081. Curcumin relieves CUMS-induced depressive-like behaviors through PGC-1α/FNDC5/BDNF pathway
2082. The effect of 8 weeks of interval and resistance training on expression PGC 1α, AMPK, TFAM Elderly rat heart cells
2083. Propofol ameliorates acute postoperative fatigue and promotes glucagon-regulated hepatic gluconeogenesis by activating CREB/PGC-1α and accelerating fatty acids …
2084. Dipeptidyl peptidase-4 involved in regulating mitochondria function in cardiomyocytes through Nrf2 and PGC-1α signaling
2085. Neuroscience of Disease: PV-specific loss of the transcriptional coactivator PGC-1α slows down the evolution of epileptic activity in an acute ictogenic model
2086. Agrimol B inhibits colon carcinoma progression by blocking mitochondrial function through the PGC-1α/NRF1/TFAM signaling pathway
2087. Cardiac Fibroblast-Specific Knockout of PGC-1α Accelerates AngII-Induced Cardiac Remodeling
2088. Twist1 downregulation of PGC-1α decreases fatty acid oxidation in tubular epithelial cells, leading to kidney fibrosis
2089. … of HIIT vs. CET exercise training on high-fat-high-fructose diet-induced hyperglycemia, hyperlipidemia, and histopathology of liver in rats: regulation of SIRT1/PGC-1α
2090. The Effect of Moderate and High Intensity Resistance Training on the Expression of PGC-1α, TFAM and AMPK of Cardiomyocytes in Elderly Rats
2091. Effect of lactate administration on exercise-induced PGC-1α mRNA expression in Thoroughbreds
2092. Maternal obesity inhibits placental angiogenesis by down-regulating the SIRT1/PGC-1α pathway
2093. Rhein Relieves Oxidative Stress in an Aβ Model 1-42 Oligomer-Burdened by Activating the SIRT1/Neuron PGC-1α-Regulated Mitochondrial Biogenesis
2094. Effect of post-exercise muscle cooling on PGC-1α and VEGF mRNA expression in Thoroughbreds
2095. Crocetin protects cardiomyocytes against hypoxia/reoxygenation injury by attenuating Drp1-mediated mitochondrial fission via PGC-1α
2096. Arsenic-Induced Mitochondria-Mediated Apoptosis is Associated with PGC-1α Decrease in Rat Brain
2097. Bioactives From Coffee By-Products Stimulate Liver Metabolism and Mitochondrial Bioenergetics via AMPK/PGC-1α/Nrf2 and IRS/AKT/GLUT2 Pathways In Vitro
2098. Investigating the impact of PGC-1α-coupled metabolic reprogramming on breast cancer metastasis
2099. Involvement of the SIRT1/PGC-1α signaling pathway in noise-induced hidden hearing loss
2100. Investigation of PGC-1α function in zebrafish
2101. Canagliflozin Promotes Mitochondrial Biogenesis in Glycerol-Induced Acute Kidney Injury by Activating the AMPK/SIRT1/FOXO-3a/PGC-1α and Nrf2/HO-1 …
2102. Canagliflozin Regulates Ferroptosis, Potentially via Activating AMPK/PGC-1α/Nrf2 Signaling in HFpEF Rats
2103. PGC-1α: a metabolic regulator
2104. Beta Caryophyllene in Combination with Dexmedetomidine Synergistically Inhibits Cell Proliferation in Ovarian Cancer: Involvement of AMPK and PGC-1α …
2105. PGC‐1α is downregulated in a mouse model of obstructive cholestasis but not in a model of liver fibrosis
2106. Shenqi Lixin Decoction improves cardiac function in rats with adriamycin-induced heart failure through modulation of PGC-1α and mitochondrial apoptosis …
2107. Importance of PGC-1α gene expression in Egyptian hemodialysis patients
2108. The neuroprotection of electro-acupuncture via the PGC-1α/TFAM pathway in transient focal cerebral ischemia rats
2109. Pioneering PGC-1α-Boosted Secretome: A Novel Approach to Combating Liver Fibrosis
2110. Pterostilbene induces browning of white adipocytes via AMPK/PGC-1α pathway
2111. Study on the relationship between relieving energy crisis in myofascial trigger points with An-Pressing manipulation and AMPK/PGC-1α pathway activation
2112. Metformin induced M2 polarization to improve peripheral nerve regeneration by regulating AMPK/PGC-1α/PPAR-γ pathway
2113. The impact of prolonged and intermittent fasting on PGC-1α, Oct-4 and CK-19 liver gene expression.
2114. Investigation the effect of high intensity interval training (HIIT) with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene …
2115. PGC-1α Interacts with MicroRNA-217 to Functionally Regulate Breast Cancer Cell Proliferation
2116. A41 THE ROLE OF PGC-1α IN MURINE BONE MARROW DENDRITIC CELLS
2117. Isovitexin restores sevoflurane‑induced cognitive dysfunction by mediating autophagy through activation of the PGC-1α/FNDC5 signaling pathway
2118. Effects of eight weeks of TRX training on serum levels of PGC-1α and citrate synthase in overweight women
2119. Correction to Phytol Promotes the Formation of Slow-Twitch Muscle Fibers through PGC-1α/miRNA but Not Mitochondria Oxidation
2120. Knockdown of 11β-hydroxysteroid dehydrogenase type 1 alleviates LPS-induced myocardial dysfunction through the AMPK/SIRT1/PGC-1α pathway
2121. Influence of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 Alpha (PGC-1α) in Type 2 Diabetes
2122. Elabela-APLNR inhibits cerebral ischemia/reperfusion injury through AMPK/SIRT3/PGC-1α and Akt/Nrf2 pathways
2123. Cardiac Fibroblast-Specific Knockout of PGC-1α Accelerates AngII-Induced Cardiac Remodeling
2124. METTL3 promotes PGC-1α transcription and alleviates mitochrondrial dysfunction of diabetic nephropathy by targeting lncRNA TUG1 m6A modification
2125. IL-4 Mediated Upregulation of AMPK/SIRT1/PGC-1α Signalling Pathway Is Bypassed By Mitochondrial Complex I Downregulation By NAMPT Inhibition in Venetoclax …
2126. Peroxisome Proliferator Activated Receptor γ Coactivator-1α (PGC-1α) Activation to Enhance Macrophage Immune Function in Nontuberculous Mycobacteria (NTM) …
2127. Explore the role of irisin in mitohormesis by PGC-1α
2128. Formononetin Attenuates Renal Tubular Injury and Mitochondrial Damage in Diabetic Nephropathy Partly via Regulating Sirt1/PGC-1α Pathway
2129. Impact of the PGC-1α Gly482Ser Polymorphism on Mouse Metabolism
2130. Pathways in uremic cardiomyopathy–the intracellular orchestrator PGC-1α in cell culture and in a mouse model of uremia
2131. The effect of short endurance training on the expression level of PINK-1, Parkin and PGC-1α in the heart of nicotine-sensitized rats
2132. EFFECT OF 6 WEEKS ENDURANCE TRAINING WITH QUERCETIN SUPPLEMENTATION ON THE EXPRESSION OF MITOCHONDRIAL PGC-1α AND ATF2 GENES …
2133. … ) and Eubacterium rectal Supplementation on Skeletal Muscle Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α) Expression in Diabetic …
2134. 5′-CMP and 5′-UMP promote myogenic differentiation and mitochondrial biogenesis by activating myogenin and PGC-1α in a mouse myoblast C2C12 cell …
2135. Association of Single Nucleotide Polymorphisms of ARL15 and PGC-1α Genes with Diabetic Kidney Disease
2136. Effect of Aerobic Exercise Combined With Thyme Extract Supplementation on the PGC-1α Gene Expression in Adult Male Rats
2137. The Effect Of Eight-Week High Intensity Interval Training (Hiit) And Caffeine Intake On The PGC-1α Expression In Soleus Muscle In Diabetic Rats Induced …
2138. Correlation analysis of serum CTRP3 and PGC-1α expression with traumatic fracture healing
2139. CircRNA_0000927 promotes inflammatory response to neuronal injury via miR-126a-5p/PGC-1α axis in acute ischemic stroke
2140. … associated lung cancer proliferation and tumor growth is prevented by β-caryophyllene: Role of AMPK activation and PGC-1α/TFAM over expression
2141. Atorvastatin Induces FXR and CYP7A1 Activation as a Result of the Sequential Action of PPARγ/PGC-1α/HNF-4α in Hep3B Cells
2142. Investigation the effect of high intensity interval training (HIIT) with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene …
2143. Identifying PGC-1α-dependent hepatokines in a non-alcoholic fatty liver disease murine model
2144. Effect of HIIT and Q10 supplementation on soleus muscle PGC-1α level citrate synthase activity in obese male rats
2145. PERM1 regulates energy metabolism in the heart via ERRα/PGC− 1α axis
2146. Hyperbaric Oxygen Therapy Improves Parkinson’s Disease by Promoting Mitochondrial Biogenesis via the SIRT-1/PGC-1α Pathway. Biomolecules 2022, 12 …
2147. PPARγ and PGC-1α activators protect against diabetic nephropathy by suppressing the inflammation and NF-κB activation
2148. PGC-1α Is Indispensable in Purple Potato Promoted Intestinal Epithelial Differentiation and Mitochondrial Biogenesis
2149. Nucleolin promotes autophagy through PGC-1α in LPS-induced myocardial injury.
2150. The alteration of PGC-1α expression in younger non-professional athletes with acute medium intensity exercise model
2151. New roles for PGC-1α in diet-associated liver cancer and hepatic inflammation
2152. The Gly482Ser Polymorphism Affects PGC-1α Stability in INS-1 β-Cells
2153. The effect of an aerobic exercise course on the genes expression of Sirt-1 and PGC-1α in the left ventricle of rats with type 2 diabetes
2154. PGC-1α As A Mechanistic Driver Of Exercise-Induced Regulation Of Intermuscular Adipose: In Silico Approach Of GSEA-Guided Network Propagation
2155. AB0172 PGC-1α REGULATES AUTOPHAGY TO PROMOTE FIBROBLAST ACTIVATION AND TISSUE FIBROSIS
2156. PGC-1α in human CD4+ T cell subsets
2157. Redox signaling in acute pancreatitis: roles of PGC-1α and sulfiredoxin
2158. The effect of high-intensity interval training (HIIT) on nesfatin, irisin and resistin and gene expression of PGC-1α in Wistar rats Mozhgan Ahmadi1
2159. Corrigendum to “Estrogen-related Receptor Alpha (ERRα) is Required for PGC-1α-dependent Gene Expression in the Mouse Brain”[Neuroscience 479 (2021) 70–90]
2160. The effect of a period of high-intensity interval training on the content of AMPK and PGC-1α proteins in the heart muscle tissue of rats with type 2 diabetes
2161. 75-The Gly482Ser Polymorphism Affects PGC-1α Stability and Function in INS-1 β-Cells
2162. Synergistic Effects of Four Weeks of Endurance Training with Probiotic Supplementation on the Expression of PGC-1α and Citrate Synthase Genes in Soleus Muscles …
2163. The preclinical study of the expression changes of PGC-1α and SIRT genes
2164. Establishment of Drug-Resistant Cell Lines of Acute Myeloid Leukemia and Correlation of Sirt1 and PGC-1α Expression Levels with Drug Resistance
2165. Endoplasmic reticulum stress reduces PGC-1α in skeletal muscle through ATF4 and the mTOR-CRTC2 axis
2166. … derivative) inhibits proliferation, suppresses cell migration and invasion and decreases tumor growth of osteosarcoma: role of PGC-1α/TFAM and AMPK …
2167. The Effects of Sodium Butyrate Supplementation on the Expression Levels of PGC-1α, PPARα, and UCP-1 Genes, Serum Level of GLP-1, Metabolic Parameters …
2168. The effect of high-intensity interval training (HIIT) on nesfatin, irisin and resistin and gene expression of PGC-1α in Wistar rats
2169. Correction to: Role of Estrogen-related Receptor γ and PGC-1α/SIRT3 Pathway in Early Brain Injury After Subarachnoid Hemorrhage
2170. Secretion Of PGC-1α By Modulating Physical Exercise To Protect Improving Obesity Prevalence
2171. Effect of Endurance Training and MitoQ on Expression of PGC-1α, ERR-α, MCAD, and CPT-1α Genes in Skeletal Muscle of Male Wistar Rats
2172. Differential role of PGC-1α isoforms in the modulation of astrocytes reactive phenotype
2173. The impact of aerobic training intensity on skeletal muscle PGC-1α, interferon regulatory factor 4, and atherogenic index in obese male Wistar rats.
2174. The effects of cold water immersion post repeated sprint activity on serum PGC-1α and irisin in young active men
2175. Effect of herbal cake-separated moxibustion on behavioral stress reactions and blood lactic acid level and muscular AMPK/PGC-1α signaling in rats with chronic …
2176. Cardioprotective effect of ivabradine via the AMPK/SIRT1/PGC-1α signaling pathway in myocardial ischemia/reperfusion injury induced in H9c2 cell
2177. PGC-1α deficiency causes spontaneous kidney inflammation and increases the severity of nephrotoxic AKI
2178. Hepatic PGC-1α has minor regulatory effect on the transcriptome and metabolome during high fat high fructose diet and exercise.
2179. … , Alone and in a Mixture, Impaired Male Fertility and Sexual Behavior in Adult Rats via Suppression of Steroidogenic Genes and SIRT1/TERT/PGC-1α Pathway
2180. The effect of 4 weeks aerobic swimming training and aqueous Urtica dioica extract on PGC-1α and UCP1 gene expression and serum concentrations of irisin and …
2181. Interaction effect of 4 weeks of endurance training and octopamine on gene expression of PGC-1α in brown adipose tissue of male rats fed with DFO
2182. Decreased kidney mitochondrial content and PGC-1α following repeated low-dose cisplatin-induced kidney injury.
2183. Effects of different types of exercise on contractile properties and expressions of MuRF1, PGC-1α/FNDC5 in soleus muscle of unloaded rats
2184. Effect of Sea grapes-Antioxidants Extract on Lipid Profile and PGC-1α Levels in Obese Men: 4 Weeks Randomized-Double Blind Controlled Trial
2185. Effect of Gualou Xiebai Banxiatang on Mitochondrial Dysfunction and AMPK/PGC-1α Signaling Pathway in Rats with Ischemic Myocardial Injury
2186. … on Protective Mechanism of Dracocephalum moldavica Total Flavonoids against Myocardial Ischemia-reperfusion Injury in Rats Based on AMPK/SIRT 1/PGC-1α …
2187. Withdrawal: Exercise increases mitochondrial PGC-1α content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis.
2188. PGC-1α protects a fibrotic liver from partial hepatectomy-induced advanced liver injury through regulating cell cycle arrest.
2189. Research Article Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts.
2190. Plagiarism_The Effect of Aerobic Exercise and Caloric Restriction on Mice’s Brain Tissue PGC-1α Levels and Their Memory Abilities
2191. Energy deprivation-induced AMPK activation inhibits milk synthesis via PrlR and PGC-1α
2192. PGC-1α Pathway Time Course Phosphorylation Following Endurance Exercise: A systematic
2193. 283 Quercetin Antagonizes Tall Fescue Toxicosis-Induced Cardiovascular Toxicity in Lamb (Ovis Aries) via Modulating PGC-1α Mediated Mitochondrial Biogenesis
2194. The effect of eight weeks of high intensity interval training and moderate continuous training on PGC-1α and ERRα gene expression in subcutaneous adipose …
2195. Oxidant-Mediated Transcription and Post-Translational Modification of PGC-1α Is Required for Fibrotic Repair
2196. Anti-angiogenic effects of a novel small molecular activator of PGC-1α
2197. RENAL DENERVATION REGULATES LIPID METABOLISM THROUGH AMPK/PGC-1α PATHWAY IN DIET-INDUCED OBESE RATS
2198. A histochemical double staining protocol for GABA-α2 and CAMKII in hippocampal neurons using PGC-1α transgenic mice as an example
2199. WCN23-1034 miR-1224 of circulating extracellular vesicles induce mitochondria-mediated podocyte injury by inhibiting CREB/PGC-1α pathway in metabolic …
2200. An AMP-activated protein kinase-PGC-1α axis mediates metabolic plasticity in glioblastoma
2201. PGC-1α inhibits the NLRP3 inflammasome via preserving mitochondrial viability to protect kidney fibrosis
2202. Erratum to” Melatonin-Induced PGC-1α Improves Angiogenic Potential of Mesenchymal Stem Cells in Hindlimb Ischemia”[Biomol. Ther. 28 (2020) 240-249]
2203. 2P-225: Antioxidative effect of PGC-1α-derived peptide material conjugated with gallic acid
2204. Retraction of “GPR40 Agonist GW9508 Ameliorates Oxidized LDL-Induced Endothelial Dysfunction via the AMPK/CREB/PGC-1α Pathway”
2205. Tetramethylpyrazine nitrone exerts neuroprotection via PGC-1α/Nrf2 activation and α-synuclein clearance in Parkinson’s disease models
2206. Improvement of liver damage by clove leaf extracts in rats with acute pancreatitis regulated by SIRT1/PGC-1α/NRF1 signaling pathway
2207. Study on the correlation between methylation level of PGC-1α gene and fetal distress in pregnant women with gestational diabetes mellitus
2208. Effect of muscle exercise on metabolic disturbance induced by ovariectomy alone or with diabetes mellitus in rats; targeting the role of PGC-1α and FNDC5 expression
2209. Alterations in PGC-1α and UCP1 gene expression in epicardial aadipose tissue and serum orexin-a following aerobic exercise in high-fat diet induced obesity of male …
2210. Abstract WP154: The Role of Ethylmethylhydroxypyridine Succinate in the Induction of PGC-1α in Experimental Ischemic Damage of the Prefrontal Cortex
2211. FGF21 restores hippocampual mitochondrial dysfunction via enhancing Nrf2/HO-1 and AMPK/SirT1/PGC-1α signaling pathways to alleviate chronic …
2212. … mitochondrial damage evoke complement component C5 activation independent of component C3 in dry age‐related macular degeneration like NFE2L2/PGC‐1α …
2213. Tongmai Yangxin Pills Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1α in a Rat Model of Isoproterenol-Induced Cardiomyopathy
2214. The Effect Of Eight Weeks Of Daily Normobaric Hypoxia (60 Minutes) On PGC-1α Content Of Soleus Muscle, Insulin Resistance, And Fasting Glucose In Type 2 …
2215. Solid-Phase Synthesis of Modified Peptides Based on PGC-1α Alpha, a Regulator of Cellular Metabolism
2216. Research Article Short Alkyl Chain-Length Resorcinol Olivetol Protects Against Obesity with Mitochondrial Activation by PGC-1α Deacetylation
2217. Evaluation of SIRT1 and PGC-1α, gene expression in testicular tissue of azoospermic rats treated with busulfan after a period of swimming training
2218. Effect of Organic Selenium during HS in Broiler Chicken: The Interplay of HSP-70 and PGC-1α
2219. PGC-1α activity and mitochondrial dysfunction in preterm infants
2220. Correction to: Shen Qi Li Xin formula improves chronic heart failure through balancing mitochondrial fission and fusion via upregulation of PGC-1α
2221. Predictive value of serum PGC-1α mRNA and irisin levels on hemorrhagic transformation in patients with acute ischemic stroke
2222. SGK2 Is Elevated by the βAR-cAMP-PGC-1α Axis but Dispensable for Brown/Beige Adipose Thermogenesis
2223. Hyperbaric Oxygen Up-Regulates the Expression of PGC-1α to Improve Osteoporosis and Enhances the Effect of Treadmill Exercise On Osteoporosis In …
2224. THE EFFECT OF SIX WEEKS OF REST-PAUSE RESISTANCE TRAINING ON PGC-1α EXPRESSION IN YOUNG NON-ATHLETE MEN
2225. Leucine as regulator of mitochondrial biogenesis via modulating PGC-1α-targeting microRNAs in C2C12 myotubes
2226. AMPK/SIRT1/PGC-1α/SIRT3 pathway-independent activation of GPx1 expression by metformin in the heart of a mouse model of endometriosis
2227. Da Chaihutang Protects Liver Mitochondrial Function of Nutritionally Obese Rats via CREB/PGC-1α Pathway
2228. Enhanced Liver Regeneration of the Secretome Released from ASCs by PGC-1α-Driven Upregulation of Mitochondrial Proliferation
2229. Protein Kinase SGK2 Is Induced by the β3 Adrenergic Receptor-cAMP-PKA-PGC-1α/NT-PGC-1α Axis but Dispensable for Brown/Beige Adipose Tissue …
2230. Tangshen formula improves cholesterol uptake and efflux of macrophages induced by high lipid via activating PGC-1α/LXR/ABCA1 pathway
2231. Human dental pulp stem cells conditioned medium protects genioglossus myoblast from cobalt chloride-induced hypoxia injury through AMPK/PGC-1α pathway
2232. Melatonin Potentiates Exercise-Induced Increases in Skeletal Muscle PGC-1α and Optimizes Glycogen Replenishment
2233. Mulberry Leaf Flavonoids Ameliorate Obesity and Promote Adipose Tissue Browning Through Regulating AMPK/SIRT1/PGC-1α Signaling Pathway
2234. Enhanced hippocampal neurogenesis mediated by PGC-1α-activated OXPHOS after neonatal low-dose Propofol exposure
2235. Twist1 downregulation of PGC-1α decreases fatty acid oxidation in tubular epithelial cells, leading to kidney fibrosis: Erratum
2236. Corrigendum to’Balasubramide derivative 3C modulates microglia activation via CaMKKβ-dependent AMPK/PGC-1α pathway in neuroinflammatory conditions'[Brain …
2237. … Glycolysis of HL-60 Cells by Modulating Sirtuin 1 (SIRT1)/Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α)/Hypoxia-Inducible Factor-2α …
2238. Retraction Note to: MiR-138-5p exacerbates hypoxia/reperfusion-induced heart injury through the inactivation of SIRT1-PGC-1α.
2239. Effects of quercetin on hepatic fibroblast growth factor-21 (FGF-21) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) levels in rats …
2240. … against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1α …
2241. … /δ preserves mitochondrial respiratory function after ischemia/reperfusion via stimulation of fatty acid oxidation-linked respiration and PGC-1α/NRF-1 signaling