FOXO3

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FOXO3 belongs to the O subclass of the forkhead family of transcription factorswhich are characterized by a distinct fork head DNA-binding domain. There are three other FoxO family members in humans, FOXO1, FOXO4 and FOXO6. These transcription factors share the ability to be inhibited and translocated out of the nucleus on phosphorylation by proteins such as Akt/PKB in the PI3Ksignaling pathway (aside from FOXO6, which may be constitutively nuclear).[6]Other post-translational modifications including acetylation and methylation are seen and can result in increased or altered FOXO3a activity.

This protein likely functions as a trigger for apoptosis through upregulation of genes necessary for cell death, such as Bim and PUMA,[7] or downregulation of anti-apoptotic proteins such as FLIP.[8]

Gopinath et al.(2014)[9] demonstrate a functional requirement for FOXO3 as a regulator of Notch signaling pathway (an essential regulator of quiescence in adult stem cells) in the self-renewal of stem cells during muscle regeneration.

It is thought that FOXO3a is also involved in protection from oxidative stress by upregulating antioxidants such as catalase and MnSOD. Ron DePinho‘s group generated Foxo3 knockout mice, and showed that female exhibit a dramatic age-dependent infertility, due to premature ovarian failure.

Clinical significance

Deregulation of FOXO3a is involved in tumorigenesis,[10] for example translocation of this gene with the MLLgene is associated with secondary acute leukemia. Downregulation of FOXO3a activity is often seen in cancer (e.g. by increase in Akt activity resulting from loss of PTEN). FOXO3 is known as a tumour suppressor.

Alternatively spliced transcript variants encoding the same protein have been observed.[11]

Association with longevity

A variant of FOXO3 has been shown to be associated with longevity in humans. It is found in most centenarians across a variety of ethnic groups around the world.[12][13] The homologous genes daf-16 in the nematode C. elegans and dFOXO in the fruit fly are also associated with longevity in those organisms.

  1. FoxO3 Controls Autophagy in Skeletal Muscle In Vivo
  2. FoxO3 Regulates Neural Stem Cell Homeostasis
  3. FoxO3 Coordinately Activates Protein Degradation by the Autophagic/Lysosomal and Proteasomal Pathways in Atrophying Muscle Cells
  4. PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription
  5. The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor
  6. Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor
  7. Foxo3 is required for the regulation of oxidative stress in erythropoiesis
  8. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2
  9. Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle
  10. Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation
  11. Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth
  12. SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage
  13. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
  14. Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis
  15. GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy
  16. The Transcription of FOXO Genes Is Stimulated by FOXO3 and Repressed by Growth Factors
  17. Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses
  18. Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells
  19. Mitochondria and FOXO3: breath or die
  20. Glioma‐Initiating Cell Elimination by Metformin Activation of FOXO3 via AMPK
  21. Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway
  22. Foxo3 Is Essential for the Regulation of Ataxia Telangiectasia Mutated and Oxidative Stress-mediated Homeostasis of Hematopoietic Stem Cells
  23. Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity
  24. FOXO3: A Major Gene for Human Longevity – A Mini-Review
  25. Posttranslational modifications control FoxO3 activity during denervation
  26. Activation of the AMPK–FOXO3 Pathway Reduces Fatty Acid–Induced Increase in Intracellular Reactive Oxygen Species by Upregulating Thioredoxin
  27. FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer
  28. FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3
  29. Hepatic Suppression of Foxo1 and Foxo3 Causes Hypoglycemia and Hyperlipidemia in Mice
  30. A FOXO3–IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses
  31. Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK–FOXO3 pathway
  32. Akt Phosphorylates MstI and Prevents Its Proteolytic Activation, Blocking FOXO3 Phosphorylation and Nuclear Translocation
  33. The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration
  34. Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses
  35. Akt Phosphorylates MstI and Prevents Its Proteolytic Activation, Blocking FOXO3 Phosphorylation and Nuclear Translocation
  36. GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal–induced apoptosis
  37. FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway
  38. Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6
  39. FOXO3 Promotes Quiescence in Adult Muscle Stem Cells during the Process of Self-Renewal
  40. Specificity of the requirement for Foxo3 in primordial follicle activation
  41. Oxidative Stress Modulates Complement Factor H Expression in Retinal Pigmented Epithelial Cells by Acetylation of FOXO3*
  42. Oxidative Stress Modulates Complement Factor H Expression in Retinal Pigmented Epithelial Cells by Acetylation of FOXO3
  43. FOXO3 Shares Common Targets with ASCL1 Genome-wide and Inhibits ASCL1-Dependent Neurogenesis
  44. ROS‐mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3−/− mice
  45. Bimodal regulation of FoxO3 by AKT and 14-3-3
  46. Lysine methylation of FOXO3 regulates oxidative stress‐induced neuronal cell death
  47. Genome‐wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling
  48. The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor
  49. Methylation by Set9 modulates FoxO3 stability and transcriptional activity
  50. SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth
  51. FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells
  52. FoxO3 induces reversible cardiac atrophy and autophagy in a transgenic mouse model
  53. Mechanical Unloading Activates FoxO3 to Trigger Bnip3‐Dependent Cardiomyocyte Atrophy
  54. SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism
  55. FOXO3 Regulates CD8 T Cell Memory by T Cell-Intrinsic Mechanisms
  56. FOXO3 Deficiency Leads to Increased Susceptibility to Cigarette Smoke-Induced Inflammation, Airspace Enlargement, and Chronic Obstructive Pulmonary Disease
  57. FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage
  58. Wnt/β-Catenin Signaling Protects Mouse Liver against Oxidative Stress-induced Apoptosis through the Inhibition of Forkhead Transcription Factor FoxO3
  59. Autophagy protects chondrocytes from glucocorticoids-induced apoptosis via ROS/Akt/FOXO3 signaling
  60. Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice
  61. Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity
  62. Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3
  63. miR-182 attenuates atrophy-related gene expression by targeting FoxO3 in skeletal muscle
  64. Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice
  65. Repression of BIRC5/Survivin by FOXO3/FKHRL1 Sensitizes Human Neuroblastoma Cells to DNA Damage-induced Apoptosis
  66. FoxO3 Controls Dangerous Proteolytic Liaisons
  67. FoxO3 Mediates Antagonistic Effects of Glucocorticoids and Interleukin-2 on Glucocorticoid-Induced Leucine Zipper Expression
  68. Tumor suppressor FOXO3 participates in the regulation of intestinal inflammation
  69. Shorter Men Live Longer: Association of Height with Longevity and FOXO3 Genotype in American Men of Japanese Ancestry
  70. Resveratrol Prevents Oxidative Stress-Induced Senescence and Proliferative Dysfunction by Activating the AMPK–FOXO3 Cascade in Cultured Primary Human Keratinocytes
  71. Mst1/Mst2 Regulate Development and Function of Regulatory T Cells through Modulation of Foxo1/Foxo3 Stability in Autoimmune Disease
  72. Insulin-FOXO3 Signaling Modulates Circadian Rhythms via Regulation of Clock Transcription
  73. FOXO3 Gene Variants and Human Aging: Coding Variants May Not Be Key Players
  74. FOXO3 expression during colorectal cancer progression: biomarker potential reflects a tumour suppressor role
  75. FLT3 ligand regulates apoptosis through AKT-dependent inactivation of transcription factor FoxO3
  76. FOXO3 Selectively Amplifies Enhancer Activity to Establish Target Gene Regulation
  77. Neuronal Death by Oxidative Stress Involves Activation of FOXO3 through a Two-Arm Pathway That Activates Stress Kinases and Attenuates Insulin-like Growth Factor I Signaling
  78. Auranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53
  79. Regulation of FOXO3 by phosphorylation and methylation in hepatitis C virus infection and alcohol exposure
  80. FoxO3 Transcription Factor and Sirt6 Deacetylase Regulate Low Density Lipoprotein (LDL)-cholesterol Homeostasis via Control of the Proprotein Convertase Subtilisin/Kexin Type 9 (Pcsk9) Gene Expression
  81. Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate
  82. The MicroRNA-132 and MicroRNA-212 Cluster Regulates Hematopoietic Stem Cell Maintenance and Survival with Age by Buffering FOXO3 Expression
  83. SIRT3 interactions with FOXO3 acetylation, phosphorylation and ubiquitinylation mediate endothelial cell responses to hypoxia
  84. Inactivation of the forkhead transcription factor FoxO3 is essential for PKB-mediated survival of hematopoietic progenitor cells by kit ligand
  85. FOXO3 Regulates the CD8 T Cell Response to a Chronic Viral Infection
  86. FOXO3‐mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis
  87. Expression of microRNA-96 and its potential functions by targeting FOXO3 in non-small cell lung cancer
  88. The FoxO3 gene and cause‐specific mortality
  89. FOXO3 Modulates Endothelial Gene Expression and Function by Classical and Alternative Mechanisms
  90. Sequence variation at the human FOXO3 locus: a study of premature ovarian failure and primary amenorrhea
  91. Analysis of FOXO3 mutation in 114 Chinese women with premature ovarian failure
  92. The tumour suppressor FOXO3 is a key regulator of mantle cell lymphoma proliferation and survival
  93. Reactive oxygen species and age-related genes p66Shc, sirtuin, FoxO3 and klotho in senescence
  94. Antiaging Properties of a Grape-Derived Antioxidant Are Regulated by Mitochondrial Balance of Fusion and Fission Leading to Mitophagy Triggered by a Signaling Network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN
  95. Runx1 Is a Co-activator with FOXO3 to Mediate Transforming Growth Factor β (TGFβ)-induced Bim Transcription in Hepatic Cells
  96. MiR-498 regulated FOXO3 expression and inhibited the proliferation of human ovarian cancer cells
  97. FOXO3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra
  98. Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts
  99. Mitochondrial Dysfunction Launches Dexamethasone-Induced Skeletal Muscle Atrophy via AMPK/FOXO3 Signaling
  100. FOXO3 Growth Inhibition of Colonic Cells Is Dependent on Intraepithelial Lipid Droplet Density
  101. Glucocorticoid-induced Leucine Zipper (GILZ) Promotes the Nuclear Exclusion of FOXO3 in a Crm1-dependent Manner
  102. FOXO3 Is a Glucocorticoid Receptor Target and Regulates LKB1 and Its Own Expression Based on Cellular AMP Levels via a Positive Autoregulatory Loop
  103. FOXO3-mediated up-regulation of Bim contributes to rhein-induced cancer cell apoptosis
  104. Gonadal Expression of Foxo1, but Not Foxo3, Is Conserved in Diverse Mammalian Species
  105. The anti-inflammatory and antioxidative effects of nicotinamide, a vitamin B3 derivative, are elicited by FoxO3 in human gestational tissues: implications for preterm birth
  106. Cdk5–Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer’s disease models
  107. Roles of the circular RNA circ-Foxo3 in breast cancer progression
  108. Activation of autophagy by FOXO3 regulates redox homeostasis during osteogenic differentiation
  109. Prolactin Signaling through the Short Form of Its Receptor Represses Forkhead Transcription Factor FOXO3 and Its Target Gene Galt Causing a Severe Ovarian Defect
  110. FOXO3
  111. Bcr–Abl activates the AKT/FoxO3 signalling pathway to restrict transforming growth factor‐β‐mediated cytostatic signals
  112. A Cross‐Talk Between Stromal Cell‐Derived Factor‐1 and Transforming Growth Factor‐β Controls the Quiescence/Cycling Switch of CD34+ Progenitors Through FoxO3 and Mammalian Target of Rapamycin
  113. FOXO3 Encodes a Carcinogen-Activated Transcription Factor Frequently Deleted in Early-Stage Lung Adenocarcinoma
  114. Mutation of Foxo3 Causes Adult Onset Auditory Neuropathy and Alters Cochlear Synapse Architecture in Mice
  115. Cell-Penetrating TAT-FOXO3 Fusion Proteins Induce Apoptotic Cell Death in Leukemic Cells
  116. miR-155 is upregulated in patients with active tuberculosis and inhibits apoptosis of monocytes by targeting FOXO3
  117. Lacritin Rescues Stressed Epithelia via Rapid Forkhead Box O3 (FOXO3)-associated Autophagy That Restores Metabolism
  118. SMAD3 augments FoxO3-induced MuRF-1 promoter activity in a DNA-binding-dependent manner
  119. A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis
  120. Expression and Function of Apoptosis Initiator FOXO3 in Granulosa Cells During Follicular Atresia in Pig Ovaries
  121. Regulation of cell cycle progression by forkhead transcription factor FOXO3 through its binding partner DNA replication factor Cdt1
  122. Foxo3−/− mice demonstrate reduced numbers of pre-B and recirculating B cells but normal splenic B cell sub-population distribution
  123. miR-451 regulates FoxO3 nuclear accumulation through Ywhaz in human colorectal cancer
  124. FoxO3 inactivation promotes human cholangiocarcinoma tumorigenesis and chemoresistance through Keap1‐Nrf2 signaling
  125. APRIL Binding to BCMA Activates a JNK2–FOXO3–GADD45 Pathway and Induces a G2/M Cell Growth Arrest in Liver Cells
  126. FOXO3 is essential for CD44 expression in pancreatic cancer cells
  127. Inhibition of FOXO3 Tumor Suppressor Function by βTrCP1 through Ubiquitin-Mediated Degradation in a Tumor Mouse Model
  128. Expression and Localisation of FoxO3 and FoxO4 in Human Placenta and Fetal Membranes
  129. Protective effects of icariin‑mediated SIRT1/FOXO3 signaling pathway on intestinal ischemia/reperfusion‑induced acute lung injury
  130. MiR-592 represses FOXO3 expression and promotes the proliferation of prostate cancer cells
  131. Serine 574 phosphorylation alters transcriptional programming of FOXO3 by selectively enhancing apoptotic gene expression
  132. Downregulation of Foxo3 and TRIM31 by miR-551b in side population promotes cell proliferation, invasion, and drug resistance of ovarian cancer
  133. PS341 inhibits hepatocellular and colorectal cancer cells through the FOXO3/CTNNB1 signaling pathway
  134. Ergosterol peroxide activates Foxo3-mediated cell death signaling by inhibiting AKT and c-Myc in human hepatocellular carcinoma cells
  135. Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa
  136. Tumor suppressor FOXO3 regulates ribonucleotide reductase subunit RRM2B and impacts on survival of cancer patients
  137. Reprogramming ovarian and breast cancer cells into non-cancerous cells by low-dose metformin or SN-38 through FOXO3 activation
  138. Hepatitis C and Alcohol Exacerbate Liver Injury by Suppression of FOXO3
  139. The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance
  140. Tumor suppressor FOXO3 mediates signals from the EGF receptor to regulate proliferation of colonic cells
  141. Knockdown of FOXO3 induces primordial oocyteactivation in pigs
  142. Pachastrissamine from Pachastrissa sp. Inhibits Melanoma Cell Growth by Dual Inhibition of Cdk2 and ERK‐mediated FOXO3 Downregulation
  143. Apelin regulates FoxO3 translocation to mediate cardioprotective responses to myocardial injury and obesity
  144. FOXO3/FKHRL1 is activated by 5-aza-2-deoxycytidine and induces silenced caspase-8 in neuroblastoma
  145. C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma
  146. Epigenetic control of type 2 and 3 deiodinases in myogenesis: role of Lysine-specific Demethylase enzyme and FoxO3
  147. A Novel Role for FOXO3 in Human Labor: Increased Expression in Laboring Myometrium, and Regulation of Proinflammatory and Prolabor Mediators in Pregnant Human Myometrial Cells
  148. FOXO3 and Related Transcription Factors in Development, Aging, and Exceptional Longevity
  149. Different roles of Foxo1 and Foxo3 in the control of endothelial cell morphology
  150. Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways
  151. IKK-β mediates chemoresistance by sequestering FOXO3; A critical factor for cell survival and death
  152. A class I histone deacetylase inhibitor, entinostat, enhances lapatinib efficacy in HER2-overexpressing breast cancer cells through FOXO3-mediated Bim1 expression
  153. FOXO3–NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function
  154. miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways
  155. Glutathione Suppresses Cerebral Infarct Volume and Cell Death after Ischemic Injury: Involvement of FOXO3 Inactivation and Bcl2 Expression
  156. Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes
  157. Expression of constitutively active FoxO3 in murine forebrain leads to a loss of neural progenitors
  158. MicroRNA-184 promotes proliferation ability of glioma cells by regulating FOXO3
  159. A Genome-Wide mRNA Screen and Functional Analysis Reveal FOXO3 as a Candidate Gene for Chicken Growth
  160. MicroRNA-223 Is Upregulated in Active Tuberculosis Patients and Inhibits Apoptosis of Macrophages by Targeting FOXO3
  161. C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy
  162. Identification and characterization of two functional variants in the human longevity gene FOXO3
  163. Foxo1 and Foxo3 help Foxp3
  164. FOXO3 Transcription Factor Is Essential for Protecting Hematopoietic Stem and Progenitor Cells from Oxidative DNA Damage
  165. RNA interference-mediated silencing of Foxo3 in antigen-presenting cells as a strategy for the enhancement of DNA vaccine potency
  166. FOXO3 Is Inhibited by Oncogenic PI3K/Akt Signaling but Can Be Reactivated by the NSAID Sulindac Sulfide
  167. Autophagy in Muscle of Glucose-Infusion Hyperglycemia Rats and Streptozotocin-Induced Hyperglycemia Rats via Selective Activation of m-TOR or FoxO3
  168. A novel AMPK activator from Chinese herb medicine and ischemia phosphorylate the cardiac transcription factor FOXO3
  169. Tolerogenic pDCs: spotlight on Foxo3
  170. LncRNA UCA1 impacts cell proliferation, invasion, and migration of pancreatic cancer through regulating miR‐96/FOXO3
  171. Evidence for AKT-independent regulation of FOXO1 and FOXO3 in haematopoietic stem and progenitor cells
  172. FoxO3 is a negative regulator of primary CD8+ T‐cell expansion but not of memory formation
  173. Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism
  174. Reversal of Muscle Atrophy by Zhimu-Huangbai Herb-Pair via Akt/mTOR/FoxO3 Signal Pathway in Streptozotocin-Induced Diabetic Mice
  175. Restraining FOXO3-dependent transcriptional BMF activation underpins tumour growth and metastasis of E-cadherin-negative breast cancer
  176. FoxO3 increases miR-34a to cause palmitate-induced cholangiocyte lipoapoptosis
  177. Regulation of the Tumor Suppressor FOXO3 by the Thromboxane-A2 Receptors in Urothelial Cancer
  178. MicroRNA-34a Suppresses Autophagy in Alveolar Type II Epithelial Cells in Acute Lung Injury by Inhibiting FoxO3 Expression
  179. FoxO3 suppresses Myc-driven lymphomagenesis
  180. MicroRNA-223 Promotes Type I Interferon Production in Antiviral Innate Immunity by Targeting Forkhead Box Protein O3 (FOXO3)
  181. FOXO3 variants are beneficial for longevity in Southern Chinese living in the Red River Basin: A case-control study and meta-analysis
  182. Supplementation of Magnolol Attenuates Skeletal Muscle Atrophy in Bladder Cancer-Bearing Mice Undergoing Chemotherapy via Suppression of FoxO3 Activation and Induction of IGF-1
  183. PLK1 is a binding partner and a negative regulator of FOXO3 tumor suppressor
  184. A Peroxidase Peroxiredoxin 1-Specific Redox Regulation of the Novel FOXO3 microRNA Target let-7
  185. Altered FoxO3 expression and apoptosis in granulosa cells of women with polycystic ovary syndrome
  186. FOXO1, FOXO3, AND FOXO4 are differently expressed during mouse oocyte maturation and preimplantation embryo development
  187. Grape polyphenols affect mRNA expression of PGHS-2, TIS11b and FOXO3 in endometrium of heifers under ACTH-induced stress
  188. The interaction between acetylation and serine-574 phosphorylation regulates the apoptotic function of FOXO3
  189. Threonine 32 (Thr32) of FoxO3 is critical for TGF-β-induced apoptosis via Bim in hepatocarcinoma cells
  190. Pro-apoptotic BIM is an essential initiator of physiological endothelial cell death independent of regulation by FOXO3
  191. LKB1 downregulation may be independent of promoter methylation or FOXO3 expression in head and neck cancer
  192. Association Study to Evaluate FoxO1 and FoxO3 Gene in CHD in Han Chinese
  193. Measles virus nucleocapsid protein, a key contributor to Paget’s disease, increases IL-6 expression via down-regulation of FoxO3/Sirt1 signaling
  194. Association Analysis of FOXO3 Longevity Variants With Blood Pressure and Essential Hypertension
  195. Multifaceted functions of the forkhead box transcription factors FoxO1 and FoxO3 in skin
  196. Computational Identification and Modeling of Crosstalk between Phosphorylation, O-β-glycosylation and Methylation of FoxO3 and Implications for Cancer Therapeutics
  197. Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo
  198. Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress
  199. Longevity-Associated FOXO3 Genotype and its Impact on Coronary Artery Disease Mortality in Japanese, Whites, and Blacks: A Prospective Study of Three American Populations
  200. BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer
  201. Identification of the tumor‑suppressive function of circular RNA FOXO3 in non‑small cell lung cancer through sponging miR‑155
  202. CDK6 protects epithelial ovarian cancer from platinum‐induced death via FOXO3 regulation
  203. FOXO3 Knockdown Accelerates Development of Bovine Primordial Follicles
  204. FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice
  205. MyoD- and FoxO3-mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation
  206. The role of FOXO3 in DNA damage response in thyrocytes
  207. Association Between Genetic Variation in FOXO3 and Reductions in Inflammation and Disease Activity in Inflammatory Polyarthritis
  208. Transcriptional factor FOXO3 negatively regulates the expression of nm23‐H1 in non‐small cell lung cancer
  209. Nuclear FOXO3 predicts adverse clinical outcome and promotes tumor angiogenesis in neuroblastoma
  210. FoxO transcription factors and endurance training: a role for FoxO1 and FoxO3 in exercise-induced angiogenesis
  211. The poly(ADP-ribosyl)ation of FoxO3 mediated by PARP1 participates in isoproterenol-induced cardiac hypertrophy
  212. Association analysis of common variants in FOXO3 with type 2 diabetes in a South Indian Dravidian population
  213. Mitochondria and FOXO3 in stem cell homeostasis, a window into hematopoietic stem cell fate determination
  214. Houttuynia cordata Thunb Promotes Activation of HIF-1A–FOXO3 and MEF2A Pathways to Induce Apoptosis in Human HepG2 Hepatocellular Carcinoma Cells
  215. MiR-629 promotes human pancreatic cancer progression by targeting FOXO3
  216. The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer
  217. FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis
  218. FOXO3 rs12212067: T > G Association with Active Tuberculosis in Han Chinese Population
  219. Geminin facilitates FoxO3 deacetylation to promote breast cancer cell metastasis
  220. Metformin Induces FOXO3-Dependent Fetal Hemoglobin Production in Primary Erythroid Cells
  221. Knockdown of transcription factor forkhead box O3 (FOXO3) suppresses erythroid differentiation in human cells and zebrafish
  222. Senescence of human skin-derived precursors regulated by Akt-FOXO3-p27KIP1/p15INK4b signaling
  223. Aberrant miR-182 expression promotes melanomametastasis by repressing FOXO3 andmicrophthalmia-associated transcription factor
  224. Physical inactivity induces the atrophy of skeletal muscle of rats through activating AMPK/FoxO3 signal pathway
  225. Regulation of FOXO3 subcellular localization by Kit ligand in the neonatal mouse ovary
  226. Paeonol protects against TNF-α-induced proliferation and cytokine release of rheumatoid arthritis fibroblast-like synoviocytes by upregulating FOXO3 through inhibition of miR-155 expression
  227. Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6
  228. Foxo3 gene expression and oxidative status in beta-thalassemia minor subjects
  229. MicroRNA-30c-5p inhibits NLRP3 inflammasome-mediated endothelial cell pyroptosis through FOXO3 down-regulation in atherosclerosis
  230. Tanshinol suppresses inflammatory factors in a rat model of vascular dementia and protects LPS-treated neurons via the MST1-FOXO3 signaling pathway
  231. Lineage-specific growth inhibition of NK cell lines by FOXO3 in association with Akt activation status
  232. Systems Genetic Analyses Highlight a TGFβ-FOXO3 Dependent Striatal Astrocyte Network Conserved across Species and Associated with Stress, Sleep, and Huntington’s Disease
  233. Overexpression of FOXO3, MYD88, and GAPDH Identified by Suppression Subtractive Hybridization in Esophageal Cancer Is Associated with Autophagy
  234. Severe hearing loss and outer hair cell death in homozygous Foxo3 knockout mice after moderate noise exposure
  235. Association study of polymorphisms in FOXO3, AKT1 and IGF-2R genes with human longevity in a Han Chinese population
  236. Forkhead Box O3A (FOXO3) and the Mitochondrial Disulfide Relay Carrier (CHCHD4) Regulate p53 Protein Nuclear Activity in Response to Exercise
  237. Intestinal inflammation requires FOXO3 and prostaglandin E2-dependent lipogenesis and elevated lipid droplets
  238. SIRT1/FoxO3 axis alteration leads to aberrant immune responses in bronchial epithelial cells
  239. Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies
  240. FOXO3, estrogen receptor alpha, and androgen receptor impact tumor growth rate and infiltration of dendritic cell subsets differentially between male and female mice
  241. FOXO3 Inhibits Human Gastric Adenocarcinoma (AGS) Cell Growth by Promoting Autophagy in an Acidic Microenvironment
  242. Decreased FOXO3 within advanced human colon cancer: implications of tumour suppressor function
  243. Food Intolerance: Associations with the rs12212067 Polymorphism of FOXO3 in Crohn’s Disease Patients in New Zealand
  244. Tumor-suppressive activity of 1,25-dihydroxyvitamin D3 against kidney cancer cells via up-regulation of FOXO3
  245. The FOXO3/PGC-1β signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma
  246. Gossypol Acetic Acid Prevents Oxidative Stress-Induced Retinal Pigment Epithelial Necrosis by Regulating the FoxO3/Sestrin2 Pathway
  247. REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival
  248. PTEN/FOXO3/AKT pathway regulates cell death and mediates morphogenetic differentiation of Colorectal Cancer Cells under Simulated Microgravity
  249. miR-487a-3p upregulated in type 1 diabetes targets CTLA4 and FOXO3
  250. Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells
  251. FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration
  252. Correlations of Foxo3 and Foxo4 expressions with clinicopathological features and prognosis of bladder cancer
  253. The Role of Foxo3 in Leydig Cells
  254. FOXO3-mediated chemo-protection in high-stage neuroblastoma depends on wild-type TP53 and SESN3
  255. A TLR/AKT/FoxO3 immune tolerance–like pathway disrupts the repair capacity of oligodendrocyte progenitors
  256. Dietary miR-451 protects erythroid cells from oxidative stress via increasing the activity of Foxo3 pathway
  257. AMP-activated protein kinase stabilizes FOXO3 in primary myotubes
  258. Chapter Eight – FOXO3 and Exceptional Longevity: Insights From Hydra to Humans
  259. Carbocysteine counteracts the effects of cigarette smoke on cell growth and on the SIRT1/FoxO3 axis in bronchial epithelial cells
  260. Investigation of FoxO3 dynamics during erythroblast development in β-thalassemia major
  261. Lower FOXO3 mRNA expression in granulosa cells is involved in unexplained infertility
  262. Transcriptional regulation of FoxO3 gene by glucocorticoids in murine myotubes
  263. Forkhead box O3 (FoxO3) regulates kidney tubular autophagy following urinary tract obstruction
  264. MicroRNA-223-3p regulates cell chemo-sensitivity by targeting FOXO3 in prostatic cancer
  265. FoxO3 hastens autophagy and shrinks the heart but does not curtail pathological hypertrophy in adult mice
  266. Unravelling the role of fatty acid metabolism in cancer through the FOXO3-FOXM1 axis
  267. The forkhead transcription factor Foxo3 negatively regulates natural killer cell function and viral clearance in myocarditis
  268. Chromosome 6q deletion correlates with poor prognosis and low relative expression of FOXO3 in chronic lymphocytic leukemia patients.
  269. The tubulin inhibitor MG-2477 induces autophagy-regulated cell death, ROS accumulation and activation of FOXO3 in neuroblastoma
  270. An intronic single-nucleotide polymorphism (rs13217795) in FOXO3 is associated with asthma and allergic rhinitis: a case–case–control study
  271. MiR-155-5p promotes fibroblast cell proliferation and inhibits FOXO signaling pathway in vulvar lichen sclerosis by targeting FOXO3 and CDKN1B
  272. Pharmacological Induction of FOXO3 Is a Potential Treatment for Sickle Cell Disease
  273. Recent advances in understanding the role of FOXO3
  274. O-GlcNAcylation mediates metastasis of cholangiocarcinoma through FOXO3 and MAN1A1
  275. miR-9 upregulation leads to inhibition of erythropoiesis by repressing FoxO3
  276. Spontaneous presence of FOXO3-specific T cells in cancer patients
  277. The role of AKT and FOXO3 in preventing ovarian toxicity induced by cyclophosphamide
  278. O-GlcNAcylation of the Tumor Suppressor FOXO3 Triggers Aberrant Cancer Cell Growth
  279. Prolyl isomerase Pin1 regulates doxorubicin-inducible P-glycoprotein level by reducing Foxo3 stability
  280. Characterization of Genetic Variation in the Forkhead Box Class O3 Gene (FOXO3) in Sheep
  281. The Effect of Black Seed (Nigella sativa) Extract on FOXO3 Expression in HepG2 Cells
  282. FOXO3-dependent apoptosis limits alcohol-induced liver inflammation by promoting infiltrating macrophage differentiation
  283. Ovine forkhead box class O 3 (FOXO3) gene variation and its association with lifespan
  284. Hepatic insulin-like growth factor receptor is upregulated by activation of the GSK3B-FOXO3 pathway after partial hepatectomy.
  285. FOXO3 promoted mitophagy via nuclear retention induced by manganese chloride in SH-SY5Y cells
  286. Regulation of glucose uptake and inflammation markers by FOXO1 and FOXO3 in skeletal muscle
  287. AMBRA1 Controls Regulatory T-Cell Differentiation and Homeostasis Upstream of the FOXO3-FOXP3 Axis
  288. Dormant Pluripotent Cells Emerge during Neural Differentiation of Embryonic Stem Cells in a FoxO3-Dependent Manner
  289. CD38 Deficiency Protects Heart from High Fat Diet-Induced Oxidative Stress Via Activating Sirt3/FOXO3 Pathway
  290. Thymosin-β4 Mediates Hepatic Stellate Cell Activation by Interfering with CircRNA-0067835/miR-155/FoxO3 Signaling Pathway
  291. Association of genetic variations in FOXO3 gene with susceptibility to noise induced hearing loss in a Chinese population
  292. MicroRNA-132 Negatively Regulates Palmitate-Induced NLRP3 Inflammasome Activation through FOXO3 Down-Regulation in THP-1 Cells
  293. Amelioration of streptozotocin‑induced pancreatic β cell damage by morin: Involvement of the AMPK‑FOXO3‑catalase signaling pathway
  294. MicroRNA-182 inhibits HCMV replication through activation of type I IFN response by targeting FOXO3 in neural cells
  295. Genetic Variation in FOXO3 is Associated with Self-Rated Health in a Population-Based Sample of Older Individuals
  296. FOXO3 links autophagy to apoptosis
  297. Out FoxO’d by microRNA. Focus on “miR-182 attenuates atrophy-related gene expression by targeting FoxO3 in skeletal muscle”
  298. TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia
  299. Encoding Growth Factor Identity in the Temporal Dynamics of FOXO3 under the Combinatorial Control of ERK and AKT Kinases
  300. Loss of Murine FOXO3 in Cells of the Myeloid Lineage Enhances Myelopoiesis but Protects from K/BxN-Serum Transfer-Induced Arthritis
  301. Effect of oral isotretinoin on the nucleo‐cytoplasmic distribution of FoxO1 and FoxO3 proteins in sebaceous glands of patients with acne vulgaris
  302. Minimal Shortening of Leukocyte Telomere Length Across Age Groups in a Cross-Sectional Study for Carriers of a Longevity-Associated FOXO3 Allele
  303. Preventive effect of genistein on AOM/DSS-induced colonic neoplasm by modulating the PI3K/AKT/FOXO3 signaling pathway in mice fed a high-fat diet
  304. Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF-κB pathway by targeting FOXO3
  305. FOXO3 Expression and Function in the Pig Oocyte and Embryo
  306. [Preparation and characterization of mouse polyclonal antibody against conserved region of human FOXO3].
  307. In Silico Cloning and Preliminary Analysis of FoxO3 Gene of Gallus gallus
  308. An association study of FOXO3 variant and longevity
  309. Metabolic Cross Talk Between Foxo3 and mTOR Is Essential for Hematopoietic Stem Cell Function
  310. FoxO3 activation in hypoxic tubules prevents chronic kidney disease
  311. Analysis of association of FOXO3 gene with Trypanosoma cruzi infection and chronic Chagasic cardiomyopathy
  312. Metformin Alleviates Radiation-Induced Skin Fibrosis via the Downregulation of FOXO3
  313. Erratum: A novel AMPK activator from Chinese herb medicine and ischemia phosphorylate the cardiac transcription factor FOXO3.
  314. FOXO3 is differentially required for CD8+ T‐cell death during tolerance versus immunity
  315. The mechanism of miR-23a in regulating myocardial cell apoptosis through targeting FoxO3
  316. Functional analysis of hepatic FOXO3signalling in glucose and lipid metabolism
  317. Experimental evidences for miR-30b as a negative regulator of FOXO3 upregulated by kynurenine
  318. The mechanisms involved in miR-9 regulated apoptosis in cervical cancer by targeting FOXO3
  319. Age-Based Differences in the Genetic Determinants of Glycemic Control: A Case of FOXO3 Variations
  320. Genetic Association Analysis of Common Variants in FOXO3 Related to Longevity in a Chinese Population
  321. Imatinib Induced Re-Activation of FoxO3 Transcription Factor in CML Is Responsible for the Induction of a Quiescent Status of CD34 Leukaemic Progenitor Cells.
  322. Oxidative Stress-Mediated Activation of AKT/mTOR Signaling Pathway Leads to Myeloproliferative Syndrome in FoxO3 Null Mice: A Role for Lnk Adaptor Protein
  323. Generation of Foxo3‐targeted Mice by Injection of mRNAs Encoding Transcription Activator‐like Effector Nucleases (TALENs) into Zygotes
  324. High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway
  325. The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation
  326. FOXO3, IRF4, and xIAP Are Correlated with Immune Activation in HIV-1-Infected Men Who Have Sex with Men During Early HIV Infection
  327. Systematic transcriptome-wide analysis of mRNA–miRNA interactions reveals the involvement of miR-142-5p and its target (FOXO3) in skeletal muscle growth in chickens
  328. FOXO3 cell resilience gene neighborhood
  329. Methylation of FoxO3 regulates neuronal cell death
  330. Deficiency Of FoxO3 Augments Lung Inflammation In Response To Cigarette Smoke In Mice
  331. Highlights on FOXO3 and tumor-associated dendritic cells in prostate cancer
  332. Foxo3 negatively regulates the activation of mouse primordial oocytes
  333. FOXO3 induces ubiquitylation of AKT through MUL1 regulation
  334. FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer
  335. Loss of Foxo3 Reduces Erythroblast Apoptosis and Enhances RBC Production in Beta-Thalassemic Mice
  336. [Protective effect of ginsenoside Rg1 again PC-12 cells in OGD injury through mTOR/Akt/FoxO3 signaling pathway].
  337. FOXO3 Variants Are Associated With Lower Fetal Hemoglobin Levels In Children With Sickle Cell Disease
  338. Abstract 19547: FOXO3 Genotype Strongly Impacts Coronary Heart Disease Mortality in Three Populations
  339. Foxo3 Modulation of ATM and Oxidative Stress Mediates Distinct Functions in the Regulation of Hematopoietic Stem and Progenitor Cell Fate.
  340. Loss Of p53 Rescues The Defective Function Of Foxo3-/- Hematopoietic Stem Cells But Enhances Their Predisposition To Malignancy
  341. RNA-binding protein YTHDF3 suppresses interferon-dependent antiviral responses by promoting FOXO3 translation
  342. Molecular cloning, characterisation and functional analysis of the duck Forkhead box O3 (FOXO3) gene
  343. MiR-29a regulated FOXO3 expression and promoted the cell proliferation of human cervical cancer
  344. Correction: Shorter Men Live Longer: Association ofHeight with Longevity andFOXO3Men of Japanese Ancestry
  345. Smoking, aging, and expression of proteins related to the FOXO3 signaling pathway in lung tissues
  346. Histone deacetylase SIRT6 regulates chemosensitivity in liver cancer cells via modulation of FOXO3 activity
  347. Identification andcharacterization of two functional variants in thehuman longevity gene FOXO3
  348. KCNQ1OT1 promotes autophagy by regulating miR‐200a/FOXO3/ATG7 pathway in cerebral ischemic stroke
  349. Peroxiredoxin 1 silencing inhibited the growth and promoted apoptosis of pancreatic cancer cells via targeting FOXO3 gene
  350. Colonic PDGFRα Overexpression Accompanied Forkhead Transcription Factor FOXO3 Up-Regulation in STZ-Induced Diabetic Mice
  351. Regulation and expression of FOXO1 and FOXO3in endometrial tissue during the menstrualcycle of human and mouse
  352. VARIATION IN THE FORKHEAD BOX CLASS O3 (FOXO3) GENE AND ITS ASSOCIATION WITH LIFESPAN TRAITS IN BARKI EWES
  353. miR-132 controls pancreatic beta cell proliferation and survival in mouse model through the Pten/Akt/Foxo3 signaling
  354. Regulation of muscle atrophy-related genes by the opposing transcriptional activities of ZEB1/CtBP and FOXO3
  355. Attenuation of MUC4 potentiates the anticancer activity of auranofin via regulation of the Her2/Akt/FOXO3 pathway in ovarian cancer cells
  356. Promoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC)
  357. HH1-1, a novel Galectin-3 inhibitor, exerts anti-pancreatic cancer activity by blocking Galectin-3/EGFR/AKT/FOXO3 signaling pathway
  358. IGF-1 and FoxO3 expression profiles and developmental differences of breast and leg muscle in pekin ducks (Anas platyrhynchos domestica) during postnatal stages.
  359. Erratum: FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage
  360. Lipid Droplet Accumulation Promotes Proliferation of Colon Cancer Cells via Loss of Tumor Suppressor FoxO3
  361. FoxO3 Regulates Neural Stem Cell Homeostasis
  362. Comparison of the expression and localization of FoxO3 in normal term and gestational diabetic placentas
  363. 普通牛FoxO1、FoxO3、FoxO4基因的克隆、表达及其对肉质性状的遗传效应分析
    王玲
  364. Tu1980 Low Mitochondrial Activity in Colon Cancer Cells via Loss of FOXO3 Elevates Intracellular Lipid Droplets (LDs) to Accelerate Proliferation
  365. FOXO3 Expression in the Human Ovary [6OP]
  366. SNPing at FOXO3 to limit inflammation
  367. Forkhead box O3 (FOXO3; FOXO3A)
  368. FOXO3 IS ACTIVATED IN HIGH-RISK NEUROBLASTOMAAND CONTRIBUTES TO CHEMOTHERAPY-RESISTANCEAND ANGIOGENESIS
  369. PI3K Signaling via Foxo3 in Primordial Follicle Activation.
  370. The Role of Foxo3 in B Cell Tolerance
  371. MicroRNA-182 targets FoxO3 and attenuates glucocorticoidinduced atrophic signaling
  372. FOXO3, a Molecular Search for the Fountain of Youth
  373. SIRT3 Deacetylates FOXO3 to Mediate Mitochondrial Biogenesis during Hypoxia
  374. FoxO3 Involvement in Retinal Progenitor Cells During Vertebrate Eye Development
  375. Foxo3 controls CD4 T cells differentiation and severity to neuroinflammation (IRM15P.604)
  376. FOXO3 expression in lung tissue and lung cancer stem cells and its implication
  377. Foxo3 Transcription Factor Regulates Oxidative Stress in In Vivo Erythropoiesis.
  378. Role of HSF1 and FoxO3 in proteotoxic stress induced Macroautophagy
  379. FOXO3 regulates tumor-associated DC tolerogenicity by binding and sequestering NF-kB. (P2037)
  380. A Systems Approach Identifies Essential FOXO3 Functions in Erythroblast Enucleation Process
  381. Role of Foxo3 transcription factor in the susceptibility to central nervous system autoimmunity (P1127)
  382. Expression of p-FOXO3/FOXO3 in bladder cancer and its correlation with clinicopathology and tumor recurrence
  383. The role of Foxo3 in neutrophil homeostasis
  384. ROLES FOR FOXO1 AND FOXO3 IN REGULATION OF CANCER AND LIFESPAN IN DIETARY-RESTRICTED MICE
  385. Going from acute to chronic kidney injury with FoxO3
  386. LOWER ANKLE-BRACHIAL INDEX (ABI) AS A PREDICTOR OF FUTURE COGNITIVE DECLINE AMONG COMMUNITY-DWELLING OCTOGENARIANS: THE KOCOA PROJECT.
  387. FOXO3 and AP1 Expression in Pre-Pubertal Pig Ovaries During Follicle Development.
  388. Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes
  389. Abstract 4822: Lack of expression of FOXO3 correlates with poor prognosis on uterine sarcomas
  390. Abstract 2868: Mechanisms of transcriptional regulation of FOXO3 by cofactors upon PI3K/AKT/mTOR inhibition
  391. Regulation of foxo3 subcellular localization by kit ligand in the neonatal mouse ovary
  392. Analysis of FOXO3 Gene Polymorphisms Associated with Human Longevity
  393. Endometriosis triggers excessive activation of primordial follicles via PI3K-PTEN-Akt-Foxo3 pathway.
  394. Circular RNA circ-FoxO3 Inhibits Myoblast Cells Differentiation
  395. FOXO3 Expression and Localization During Pig Oocyte Meiosis Maturation and Embryo Early Development.
  396. Lipid droplet accumulation promotes proliferation in colon cells via loss of FOXO3-dependent cell cycle arrest
  397. Role of FOXO3 in classical Hodgkin lymphoma
  398. Computation of Effect of Nano FOXO3 Gene with Thalassemia Major
  399. FOXO3 Loss Drives Inflammation-Associated CRC: The Consequences of Being (Knock)Out-FOX’d
  400. Are FoxP2, Otx1 and FoxO3 candidates for deep homology in weakly electric fish?
  401. SIRT1 Deacetylase Is Essential for Hematopoietic Stem Cell Activity Via Regulation of Foxo3.
  402. FoxO3 transcription factor promotes autophagy after transient cerebral ischemia/reperfusion
  403. Foxo3-Mediated Redox Regulation Is Required for DNA Damage Response in Hematopoietic Stem Cells.
  404. Angiotensin-(1-7) Prevents Thyroid Hormone-induced Cardiomyocyte Hypertrophy by FOXO3 Signaling Pathway
  405. O-090 Foxo3 Is Activated In High-risk Neuroblastoma And Contributes To Chemotherapy-resistance And Angiogenesis
  406. Tongluo Xingnao Effervescent Tablets ameliorates cognitive function of SAMP8 mice via Nampt/SIRT1/FOXO3 pathway
  407. [Correlation between FOXO3 gene polymorphisms and susceptibility to occupational noise-induced deafness].
  408. Acetylation Is Critical for Foxo3 Protein Stability and Activity in Hematopoietic Stem and Progenitor Cells
  409. Investigating the Role of Nuclear FOXO3 in PTEN-Null Glioblastomas
  410. FoxO3 Gene Expression in Neural Stem Cells Isolated From Mice
  411. Functional Analysis of the FOXO3 Gene on the Induction of Fetal Hemoglobin in K562 Cells
  412. β-Catenin Signaling Protects Hepatocytes Against Stress-induced Apoptosis Through The Inhibition of FoxO3
  413. Abstract 661: Foxo3 Genotype Increases Lifespan By A Major Effect On Cardiovascular Mortality
  414. Sirtuins, the anti-ageing molecules, regulate anti-oxidant capacity via FoxO3 activity in monocytic cell line
  415. BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer
  416. TIME PERSPECTIVE AND QUALITY OF LIFE IN INDIVIDUALS WITH MULTIPLE CHRONIC CONDITIONS
  417. 04.13 The transcription factor foxo3 differentially regulates the expression of proinflammatory genes in rheumatoid fibroblast-like synoviocytes
  418. Role of the FOXO3-FOXM1 Axis in Pulmonary Hypertension
  419. Abstract B13: BLM, FOXO3, FOXK2, FOXM1, FOXR1 genes as therapeutic targets to neuroblastoma
  420. A novel AMPK activator from Chinese herb medicine and ischemia phosphorylate the cardiac transcription factor FOXO3
  421. 164. Gonadal Expression of Foxo1, but Not Foxo3, Is Conserved in Diverse Mammalian Species.
  422. Correction: Shorter Men Live Longer: Association of Height with Longevity and FOXO3 Genotype in American Men of Japanese Ancestry
  423. Theaflavins prevent cartilage degeneration via AKT/FOXO3 signaling in vitro
  424. Correction:TheroleofAKTandFOXO3inpreventingovariantoxicityinducedbycyclophosphamide
  425. A PRDX1-FOXO3 signaling pathway acts as a redox sensor controlling FOXO3 subcellular localization and target gene transactivation
  426. RNA Sequencing Of Adult Bone Marrow Erythroid Populations Reveals Significant Transcriptional Deregulation In Foxo3-/- Mutant Cells
  427. Abstract 16008: FoxO3 Triggers Robust Cardiac Atrophy via BNIP3-dependent Myocyte Autophagy
  428. FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer.
  429. Hypoxia induces the dormant state in oocytes through expression of Foxo3
  430. FOXO3 RS4946936 AND ANGPLT6 RS8112063 AREPROGNOSTIC FACTORS OF SURVIVAL IN HEMODIALYSISPATIENTS
  431. OXO3 inhibits human gastric adenocarcinoma (AGS) cell growth bypromoting autophagy in an acidic microenvironment
  432. SGK1/FOXO3 Signaling in Hypothalamic POMC Neurons Mediates Glucocorticoid-Increased Adiposity
  433. Regulation of Erythroid Cell Maturation Is Mediated by a Foxo3–mTOR Cross Talk: Outcome for Beta-Thalassemic Erythropoiesis
  434. The Role of Forkhead Transcription Factors FoxO1, FoxO3 and FoxO4 in Hematopoiesis and Leukemogenesis.
  435. Abstract 5382: LKB1 downregulation in head and neck cancer is independent of promoter methylation or FOXO3 expression.
  436. TGF-β1 enhances FOXO3 expression in human synovial fibroblasts by inhibiting miR-92a through AMPK and p38 pathways
  437. Effects of AMPK Activation on the Expression of FoxO3 mRNA in the Skeletal Muscle Protein Degradation in Rat
  438. Cellular function of chicken FOXO3 and its associations with chicken growth
  439. Erratum: A novel AMPK activator from Chinese herb medicine and ischemia phosphorylate the cardiac transcription factor FOXO3.
  440. MiR‐629 regulates hypoxic pulmonary vascular remodelling by targeting FOXO3 and PERP
  441. LINC01355 suppresses breast cancer growth through FOXO3-mediated transcriptional repression of CCND1
  442. Chromosome 6q deletioncorrelates with poor prognosisand low relative expression ofFOXO3in chronic lymphocyticleukemia patients
  443. Abstract LB-322: Synergistic effects of FOXO3 and AR to increase tolerogenicity of tumor associated dendritic cells.
  444. Characterization of FoxO3 in ROS and DNA damage-induced hepatocellular carcinoma
  445. FOXO3 on the Road to Longevity: Lessons From SNPs and Chromatin Hubs
  446. CD11b activation protects against lupus nephritis by suppressing TLR-dependent IFN responses via AKT-FOXO3-IRF7
  447. Abstract 3392: Thromboxane-A2 receptor β-isoform regulates the activity of the tumor suppressor FOXO3 via phosphorylation by ERK in urothelial cancer
  448. CDK6 protects Epithelial Ovarian Cancer from platinum-induced death via FOXO3 regulation
  449. The role of FOXO3 polymorphisms in susceptibility to tuberculosis in a Chinese population
  450. Abstract 602: FoxO3 Mediates Urotensin-II-induced MMP2 Expression In Pulmonary Artery Smooth Muscle Cells
  451. Foxo3 Regulation of Stem Cell Markers OCT4 and SOX2 in PTEN-null Glioblastomas
  452. EGF-induced intestinal cell proliferation is dependent on loss of FOXO3 activity and increased lipid droplet density (906.1)
  453. Abstract 4661: Loss of LKB1 in NSCLC confers sensitivity to MEK inhibition by regulating activation of AKT-FOXO3 pathway
  454. B19 RNAseq and chipseq analysis of FOXO3 targets in an huntington’s disease human neural stem cell model
  455. Mitoxantrone induces apoptosis in osteosarcoma cells through regulation of the Akt/FOXO3 pathway
  456. Mediation of FOXO3 Gene on Momism of Quercetin against Isoproterenol Induced Cardiotoxicity in H9C2 Cardiomyoblasts.
  457. Regulation of PERK expression by FOXO3: a vulnerability of drug-resistant cancer cells
  458. Daidzein Has Anti-Oxidant Activity in Normal Human Kidney Tubular HK-2 Cells via FOXO3/SOD2 Pathway
  459. The Role of FOXO3 in Mechanisms of Doxorubicin Resistance in Hepatocellular Carcinoma
  460. Resveratrol Induces Erythroid Maturation by Activating FOXO3 and Improves in Vivo Erythropoiesis in Normal and Beta -Thalassemic Mice
  461. New insights into the roles of the FOXO3 and P27Kip1 genes in signaling pathways
  462. Abstract 3520: Solidago virga-aurea extract induced apoptosis of breast cancer cells through FOXO3 mediated bim expression
  463. Erratum to: Minimal shortening of leukocyte telomere length across age groups in a cross-sectional study for carriers of a longevity-associated FOXO3 allele
  464. Abstract 296: Cd38 Deficiency Protects Heart From Lipid Overload-induced Oxidative Stress via Activating Sirt3/foxo3 Pathway
  465. Chasing the FOXO3: Insights into Its New Mitochondrial Lair in Colorectal Cancer Landscape
  466. CARM1 contributes to skeletal muscle wasting by mediating FoxO3 activity and promoting myofiber autophagy
  467. 1 Functional consequences of a novel IL-10 receptor alpha mutation on innate and adaptive immunity in early-onset inflammatory bowel disease
  468. 332-LB: Mir-132 Controls Pancreatic Beta-Cell Proliferation and Survival through the Pten/Akt/Foxo3 Signaling
  469. Metabolic Dysregulation: An Investigation of the Role of FOXO3 in Gluconeogensis in PTEN-Null Glioblastomas
  470. FOXO3 is involved in the tumor necrosis factor-driven inflammatory response in fibroblast-like synoviocytes
  471. FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells
  472. Knockdown of circular RNA FSCN1 impairs dendritic cell immune function through regulating the NFKB and Foxo3 signaling pathways
  473. FOXO3 Regulates Mitochondrial Content In Maturing Red Blood Cells via Autophagy-Dependent and Independent Pathways
  474. Circular RNA hsa_circ_0001368 suppresses the progression of gastric cancer by regulating miR-6506–5p/FOXO3 axis
  475. Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3
  476. Overexpression of miR‑148a inhibits viability and invasion of ovarian cancer OVCAR3 cells by targeting FOXO3
  477. Functional Analysis of Forkhead Box O3 (FOXO3) During the Myogenic Differentiation in Chicken Myoblast Cells
  478. Role of FOXO3 Activated by HIV-1 Tat in HIV-Associated Neurocognitive Disorder Neuronal Apoptosis
  479. Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis
  480. Genetic variation in FOXO3 is associated with reductionsin inflammation and disease activity in inflammatory polyarthritis
  481. Up-regulation of miR-498 inhibits cell proliferation, invasion and migration of hepatocellular carcinoma by targeting FOXO3
  482. FOXO3 Is Expressed in Ovarian Tissues and Acts as an Apoptosis Initiator in Granulosa Cells of Chickens
  483. High-glucose treatment regulates biological functions of human umbilical vein endothelial cells via Sirt1/FOXO3 pathway
  484. D96 WHY SO STRESSED? ENDOPLASMIC RETICULUM, PROTEIN FOLDING, AND OXIDATION IN LUNG DISEASE: Sirt1 Protects Against Cigarette Smoke-Induced Lung Oxidative Stress Via Foxo3-Dependent Mechanism
  485. Interleukin‐8 enhances myocilin expression, Akt‐FoxO3 signaling and myogenic differentiation in rat skeletal muscle cells
  486. 441 INTRAUTERINE GROWTH RETARDATION MODULATES SIRT1 DEACETYLASE, FOXO3 TRANSCRIPTION FACTOR, AND SUPEROXIDE DISMUTASE 2 EXPRESSION IN THE POSTNATAL CEREBRAL CORTEX.
  487. FOXO3/FKHRL1 is activated by 5-Aza-2-deoxycytidine (5-azadC) and induces silenced Caspase-8 in neuroblastoma
  488. Angelica Sinensis Polysaccharide Suppresses Epithelial-Mesenchymal Transition and Pulmonary Fibrosis via a DANCR/AUF-1/FOXO3 Regulatory Axis
  489. Probing the effect of IKK on FOXO3: a regulatory mechanism of apoptosis and autophagy in chemoresistance
  490. Down-regulation of lncRNA GAS5 attenuates neuronal cell injury through regulating miR-9/FOXO3 axis in cerebral ischemic stroke
  491. P2.03b-069 LKB1 Loss is a Novel Determinant of MEK Sensitivity Due to Alterations in AKT/FOXO3 Signaling
  492. P318 FGF10 regulates regional proliferation in the fetal heart through a FOXO3/p27kip1 pathway and promotes cell cycle reentry of adult cardiomyocytes.
  493. A Targeted Functional Clone Tracking Assay for the Identification of Tumour Suppressor Genes in BCP- ALL Implicates the Transcription Factors FOXO3 and PRDM1
  494. miR-590-3p Targets Cyclin G2 and FOXO3 to Promote Ovarian Cancer Cell Proliferation, Invasion, and Spheroid Formation
  495. Foxo3 Promotes Apoptosis of B Cell Receptor–Stimulated Immature B Cells, Thus Limiting the Window for Receptor Editing
  496. GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin 2 withdrawal-induced apoptosis
  497. Longevity-Associated Forkhead Box O3 (FOXO3) Single Nucleotide Polymorphisms are Associated with Type 2 Diabetes Mellitus in Chinese Elderly Women
  498. Abstract P531: FOXO3, a Cardiovascular Protector, is at the Hub of a 46-gene Cell Resilience “Gene Factory” on Human Chromosome 6
  499. Abstract P293: Endogenous Lats2 Plays an Important Role in Mediating Myocardial Injury Caused by Ischemia/Reperfusion Through Inhibition of FoxO3
  500. The Role of the Transcription Factor Foxo3 in Hearing Maintenance: Informed Speculation on a New Player in the Cochlea
  501. Pivotal Role of FoxO3 and mTORC1 in the Opposite Effects of SDF-1 and TGF-β on Cell Cycle Progression in CD34+ Stem/Progenitor Cells
  502. Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells
  503. D27 I WANNA BE YOUR … NOVEL MECHANISTIC INSIGHT INTO PULMONARY VASCULAR DISEASE: Role Of The Foxo3-Foxm1 Axis In Pulmonary Hypertension
  504. FoxO3 transcription factor and Sirt6 deacetylase regulate LDL-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression
  505. Abstract 13522: Annexin-A1 Bioactive Peptide Ameliorates Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) in Rats by Upregulating the Sirtuin6/FoxO3 Pathway
  506. Role of Transcription Factors FoxO3 and Myogenin in Regulation of E3 Ligases MuRF-1 and MAFbx Expression in Rat Soleus at an Early Stage of Disuse Atrophy
  507. Loss of KMT2D induces prostate cancer ROS-mediated DNA damage by suppressing the enhancer activity and DNA binding of antioxidant transcription factor FOXO3
  508. A positive feed-forward loop between LncRNA-URRCC and EGFL7/P-AKT/FOXO3 signaling promotes proliferation and metastasis of clear cell renal cell carcinoma
  509. LKB1 LOSSINDUCESCHARACTERISTICPATHWAYACTIVATIONINHUMANTUMORSANDCONFERSSENSITIVITYTOMEK INHIBITIONASSOCIATED WITHATTENUATED PI3K-AKT-FOXO3 SIGNALING
  510. Abstract P6-14-01: A class I histone deacetylase inhibitor, entinostat, enhances lapatinib efficacy in both HER2-overexpressing inflammatory and non-inflammatory breast cancer cells through FOXO3-mediated Bim1 expression
  511. FOXO3 variants are beneficial for longevity in Southern Chinese living in the Red River Basin: A case-control study and meta-analysis
  512. MEK Inhibition Induces Canonical WNT Signaling through YAP in KRAS Mutated HCT-15 Cells, and a Cancer Preventive FOXO3/FOXM1 Ratio in Combination with TNKS Inhibition
  513. A Cross-Talk Between Stromal Cell-Derived Factor-1 andTransforming Growth Factor-Controls the Quiescence/CyclingSwitch of CD34Progenitors Through FoxO3 and MammalianTarget of Rapamycin
  514. Sepsis and AMPK Activation by AICAR Differentially Regulate FoxO-1, -3 and -4
    mRNA in Striated Muscle
  515. Mo1804 A Novel Interdependent Regulation of Prostaglandin E2 (PGE2), Lipid Droplet (LD) Density, and Transcription Factor FOXO3 in Inflamed Intestinal Epithelia
  516. Tu1827 Low Mitochondrial Activity Within Intestinal Inflammation Increases Lipid Droplets (LDs) via Loss of FOXO3 to Facilitate Inflammatory Mediators
  517. Sa1460 Lipid Droplet (LD) and FoxO3 Regulatory Network Critical in Growth of Colonic Cells is Comprised of Phosphatidylinositol 3-Kinases (PI3K) and Sirtuins 6 (SIRT6)
  518. M1944 Tumor Suppressor FOXO3 Regulates Proliferation of Intestinal Epithelial Cells
  519. Mo1596 Sustained Activity of Tumor Suppressor FoxO3 Mediated by Selective Inhibitors of Nuclear Export (SINE) Crm1 Antagonists Suppresses Growth of Colon Cancer Cells
  520. M1174 Synergy of Genistein and FOXO3: Effective Inhibition of Proliferation of Colon Cancer Cells
  521. FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer
  522. 955 FOXO3 IS A NEW TARGET GENE FOR TUMOR SUPPRESSORS P53 AND P73 IN REGENERATING LIVER
  523. Upregulation of miR-34c driven by JNK and FOXO3 in livers expressing mutant Z alpha1-antitrypsin
  524. Translational Highlights from The Journal of Clinical Endocrinology & Metabolism
  525. 414 ACTIVATION OF FOXO3 IN THE LIVER INDUCES HYPOGLYCAEMIA AND METABOLIC DYSFUNCTION
  526. OC.01.2: Rorgamma-T-Expressing Regulatory T Cells Sustain Colorectal Cancer Growth Through a Foxo3-Dependent Suppression of Dendritic Cell-Derived IL-6 Production
  527. Sa1686 Age-related Change in FoxO3 Signaling Reduces Suppressive Behavior of Muscularis Macrophages and Leads to Inflammation-mediated Enteric Neuronal Loss
  528. Mo1818 Increased Lipid Droplet (LD) Density Dependent on Transcriptional Factor FOXO3 Promotes Cytokines in Inflamed Intestinal Epithelia
  529. Metformin, an AMPK Activator, Inhibits Radiation-Induced Skin Damage Via the FOXO3
  530. Mining the mouse phenome database (MPD) to find candidate modifier genes: oles revealed for serum IGF-1 levels and FOXO3 inactivation in nmd mice
  531. GSE21089: Expression of constitutively active FOXO3 in murine forebrain leads to a loss of neural progenitors
  532. FoxO3 Deficiency Augments Lung Inflammation by Downregulating Antioxidant Genes Leading to Pulmonary Emphysema by Cigarette Smoke in Mice
  533. SODIUM BUTYRATE INDUCES FOXO3 DOWNSTREAM SIGNAL PATHWAYS BY PTEN MODULATION IN GASTRIC CANCER CELL: Abstract no.: P02.08
  534. SIRT3 Deacetylates FOXO3 to Promote Mitochondrial Homeostasis in Endothelial Cells under Hypoxia
  535. FOXO3 expression and cell viability increased by inducing SIRT1 in human fibroblasts: P220
  536. Doxorubicin Resistance in Hepatocellular Carcinoma is Associated with Altered FOXO3 and SIRT6 Expression: 352
  537. The function of FoxO3-Noxa pathway in the brain of the animal model for depression
  538. Foxo3 transcription factor regulates oxidative stress in in vivo erythropoiesis
  539. Ethanol-induced expression of FOXO3 and associated tolerance is amplified in female derived dendritic cells
  540. 63 – Loss of Colonic FOXO3 Transcription Function Promotes Inflammation Mediated Cancer Progression: A Next Generation Sequencing and Bioinformatics Approach for Identification of the Immune Cell Landscape and Novel Regulators
  541. Erratum to: Minimal shortening of leukocyte telomere length across age groups in a cross-sectional study for carriers of a longevity-associated FOXO3 allele.
  542. Studium interakcí nízkomolekulárních látek s DNA-vazebnou doménou forkhead transkripčního faktoru FOXO3
  543. FOXO3在结直肠癌组织中的表达及临床意义
  544. Berberine exerts pro-apoptotic effects on PC-9 cells via activation of JNK/FOXO3 signaling
  545. Redox regulation of FOXO3 a transcription factor
  546. mTOR／Akt／FoxO3信号通路在人参皂苷Rg1抗PC-12细胞OGD损伤的作用
  547. 猪FOXO3基因的多态性和生长性状关联分析
  548. FOXO3 a基因联合干细胞修复化疗对卵巢早衰的作用及分子机制
  549. JNK/FOXO3信号通路介导黄连素促人肺腺癌PC-9细胞凋亡的研究
  550. 静脉输注过氧化氢溶液上调小鼠脾脏和外周血CD4~＋Foxo3~＋调节性T细胞
  551. FOXO3在红细胞分化过程的功能研究
  552. Das FoxO3-induzierte Transkriptom in primären humanen Endothelzellen
  553. 牛FoxO3基因的cDNA克隆及生物信息学分析
  554. t(6;11)(q21;q23) KMT2A/FOXO3
  555. 肺癌组织及其肺癌干细胞中FOXO3的表达及意义
  556. 小鼠抗人FOXO3保守区多克隆抗体的制备和鉴定
  557. Effect of mmu-miR-30b on mouse FoxO3 mRNA expression
  558. GClnc1通过SIRT3/FOXO3/SOD2信号通路促进胃癌细胞SGC7901的增殖和迁移
  559. Analyse von postnataler Neurogenese in transgenen Mäusen mit einer Vorderhirn-spezifischen, konstitutiv aktiven FoxO3 Mutante
  560. Effect of mmu-miR-30b on mouse FoxO3 mRNA expression
  561. FOXO3基因与肿瘤的研究进展
  562. AMPK/FOXO3信号通路调控鸭成肌细胞凋亡与分化的机制研究
  563. Příprava DNA-vazebné domény Forkhead transkripčního faktoru FOXO3
  564. Análise citogenética e molecular do gene FOXO3 em síndrome mielodisplásica
  565. Studium interakcí DNA-vazebné domény proteinu FOXO3 s nízkomolekulárními látkami
  566. Régulation et conséquences fonctionnelles de l’expression de GILZ (Glucocorticoid-Induced Leucine Zipper) dans les lymphocytes T. Rôle du facteur de transcription FoxO3
  567. Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice
  568. Ruolo della regolazione post-traduzionale del fattore di trascrizione FoxO3 nel muscolo scheletrico durante l’atrofia muscolare.
  569. Rôle du facteur de transcription Foxo3 dans la différenciation des LT CD4+ et la susceptibilité à l’auto-immunité
  570. FOXO3 TRANSCRIPTION FACTOR IS DELOCALIZED AND INACTIVATED IN CML PATIENTS BY BCR-ABL ONCOGENIC
  571. Suppression of autophagy through TLR4/PI3K/FoxO3 signaling impairs phagocytic degradation of microgli
  572. Polimorfismos de los genes FER Y FoxO3
  573. Michieletto, Michael. Rôles des facteurs de transcription Foxo3 et Eomes dans la différenciation et les fonctions des lymphocytes T CD4
  574. Rôle de FOXO3 dans la régulation des phases précoces de la maladie de Huntington lors de la différenciation neuronale
  575. Polimorfismos de los genes “FER Y FoxO3“: papel en la susceptibilidad, gravedad y pronóstico de la neumonía adquirida en la comunidad
  576. Análise de Alterações Cromossômicas, Mutações no Éxon 1 e do Padrão de Metilação da Região Promotora do Gene FOXO3 em Síndrome Mielodisplásica
  577. FOXO3 TRANSCRIPTION FACTOR IS DELOCALIZED AND INACTIVATED IN ACUTE MYELOID LEUKEMIA PATIENTS
  578. BLM, FOXO3, FOXK2, FOXM1, FOXR1 genes as therapeutic targets to neuroblastoma
  579. FoxO3 regulation of retinal progenitor cells in vertebrate eye development
  580. The Peroxidase PRDX1 Is Regulating FOXO3 Signaling in a Redox Dependent Manner

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