INFLAMMAGING

’Inflammaging’ refers to the chronic, low-grade inflammation that characterizes aging. Inflammaging is macrophage centered, involves several tissues and organs, including the gut microbiota, and is characterized by a complex balance between pro- and anti-inflammatory responses. Based on literature data, we argue that the major source of inflammatory stimuli is represented by endogenous/self, misplaced, or altered molecules resulting from damaged and/or dead cells and organelles (cell debris), recognized by receptors of the innate immune system. While their production is physiological and increases with age, their disposal by the proteasome via autophagy and/or mitophagy progressively declines. This ‘autoreactive/autoimmune’ process fuels the onset or progression of chronic diseases that can accelerate and propagate the aging process locally and systemically. Consequently, inflammaging can be considered a major target for antiaging strategies.

1. … Bone Marrow Progenitors Have a Proliferative Advantage in the Presence of TNF-Alpha and IFN-Gamma: Implications for Clonal Dominance in inflammaging and …
2. … enrichment modified epigenetic mechanisms in SAMP8 mouse hippocampus by reducing oxidative stress and inflammaging and achieving neuroprotection
3. “inflammaging” and Estradiol among Older US Women: A Nationally Representative Longitudinal Study
4. “inflammaging” AND ITS MANAGEMENT IN PRESBYCUSIS
5. “inflammaging” as a druggable target: a senescence-associated secretory phenotype—centered view of type 2 diabetes
6. 029 inflammaging and Bone Health in Later Life: The Hertfordshire Cohort Study
7. 115.“inflammaging” and psychosocial stress in a murine orthotopic prostate cancer model
8. 2036–inflammaging AND T-ALL: ONCOGENE-CYTOKINE INTERACTIONS AND THEIR ROLE IN LEUKEMOGENESIS
9. 25-Hydroxyvitamin D3 positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice
10. A robust characterization of inflammaging and other immune processes through multivariate analysis of cytokines from longitudinal studies
11. Absence of CCR2 results in an inflammaging environment in young mice with age‐independent impairments in muscle regeneration
12. Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging
13. Age-related Thymic Involution Perturbs Negative Selection Leading to Autoreactive T Cells That Induce Chronic Inflammation (inflammaging)
14. Age-related thymic involution perturbs negative selection leading to autoreactive T Cells that induce chronic inflammation (inflammaging)(BA11P. 141)
15. Aged gut microbiota contributes to systemical inflammaging after transfer to germ-free mice
16. Aging and Parkinson’s Disease: inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis
17. Aging-related frailty and sarcopenia. The relationship between” inflammaging” and frailty/sarcopenia.
18. An Efficient Means to Mitigate Skin inflammaging by Inhibition of the NLRP3 Inflammasome and Nfκb Pathways: A Novel Epigenetic Mechanism
19. Anti-inflammaging and antiglycation activity of a novel botanical ingredient from African biodiversity (Centevita™)
20. Anti-inflammaging effect of human alpha 1 antitrypsin
21. Anti-inflammaging effects of Lactobacillus brevis OW38 in aged mice
22. Anti‐inflammaging effects of human alpha‐1 antitrypsin
23. Are There Reliable Biomarkers for Immunosenescence and inflammaging?
24. Arterial “inflammaging” drives vascular calcification in children on dialysis
25. Association of inflammaging (inflammation+ aging) with higher prevalence of OAB in elderly population
26. Budesonide, aclidinium and formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke
27. Cachexia, sarcopenia, inflammaging and outcomes in hospitalised older people (the CaSIO study): Study protocol and preliminary results
28. Can latent synergism of intestinal pathogens be responsible for inflammaging process causing Reiter’s syndrome in a young patient HLA-B27 infected by atypical …
29. Cellular senescence and inflammaging in age-related diseases
30. Cellular Senescence and inflammaging in Age-Related Diseases
31. Characterization of blood surrogate immune-methylation biomarkers for immune cell infiltration in chronic inflammaging disorders
32. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases
33. Chronic inflammation–inflammaging–in the ageing cochlea: a novel target for future presbycusis therapy
34. Citrus fruits and inflammaging: a systematic review
35. Combating inflammaging through a Mediterranean whole diet approach: the NU-AGE project’s conceptual framework and design
36. Combined Antioxidant, Anti-inflammaging and Mesenchymal Stem Cell Treatment: A Possible Therapeutic Direction in Elderly Patients with Chronic …
37. Contribution of intestinal barrier damage, microbial translocation and HIV-1 infection status to an inflammaging signature
38. Contribution of the inflammasome to inflammaging
39. Contributions of Age-Related Thymic Involution to Immunosenescence and inflammaging
40. Corrigendum to “Mitochondrial (Dys) Function in inflammaging: Do MitomiRs Influence the Energetic, Oxidative, and Inflammatory Status of Senescent Cells?”
41. Could inflammaging and Its Sequelae Be Prevented or Mitigated?
42. Deficiency of myeloid-related proteins 8 and 14 (Mrp8/Mrp14) does not block inflammaging but prevents steatosis
43. Diabetic gut microbiota dysbiosis as an inflammaging and immunosenescence condition that fosters progression of retinopathy and nephropathy
44. Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges
45. Does physical activity attenuate inflammaging?
46. Editorial (Thematic Issue: Skin Inflammation and inflammaging)
47. Effect of inflammaging on periodontitis
48. Emerging roles of frailty and inflammaging in risk assessment of age-related chronic diseases in older adults: the intersection between aging biology and …
49. Endothelial cell senescence and inflammaging: microRNAs as biomarkers and innovative therapeutic tools
50. Erectile Dysfunction in inflammaging
51. Exercise Training for the Elderly: inflammaging and the Central Role for HSP70
52. Exploiting immune cell metabolic machinery for functional HIV cure and the prevention of inflammaging
53. EXTRACELLULAR MITOCHONDRIAL DNA PLASMA LEVELS INCREASE DURING AGING AND LONGEVITY: IMPLICATIONS FOR” inflammaging“
54. Extracellular vesicles extracted from young donor serum attenuate inflammaging via partially rejuvenating aged T-cell immunotolerance
55. Folliculo-stellate cells–Potential mediators of the inflammaging-induced hyperactivity of the hypothalamic–pituitary–adrenal axis in healthy elderly individuals
56. FP062 Complement activation mediates accelerated tubular and glomerular inflammaging in Adriamycin (Adr)-Induced FSGS
57. FP069 Extracellular Vesicles can mediate tubular inflammaging in Antibody-Mediated Rejection via Cyclin-Dependent Kinase Inhibitors
58. FP283 Continuous Hemodiafiltration with PMMA Hemofilter modulated Complement activation and Tubular inflammaging in LPS-induced Acute Kidney Injury (AKI)
59. From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?
60. From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?
61. Generation of sRAGEhigh transgenic mice to study inflammaging
62. Gut dysbiosis: a potential link between increased cancer risk in ageing and inflammaging
63. Habitual dietary intake and mediators of the inflammaging process in Brazilian older women
64. HORTICULTURAL THERAPY DELAYS IMMUNOSENESCENCE AND inflammaging IN OLDER ADULTS
65. How dietary patterns are related to inflammaging and mortality in community-dwelling older Chinese adults in Hong Kong—a prospective analysis
66. Human B cell response to the influenza vaccine is predicted by AID and decreased by inflammaging
67. Human inflammaging
68. Icariin intervenes in cardiac inflammaging through upregulation of SIRT6 enzyme activity and inhibition of the NF-kappa B pathway
69. Immunesenescence and inflammaging: a contributory factor in the poor outcome of the geriatric trauma patient
70. Immunobiography and the heterogeneity of immune responses in the elderly: a focus on inflammaging and trained immunity
71. Immunological Methods and the Concept of inflammaging in the Study of Human Aging
72. IMMUNOSENESCENCE AND inflammaging: AN INTRICATE CONNECTION
73. Immunosenescence, inflammaging, and Their Implications for Cancer and Anemia
74. Impact of clinical factors on inflammaging and Toll-like receptors responses in old age
75. Inducible thymic epithelial cell-based rejuvenation in thymic aging-associated inflammaging (Supported by NIH/NIAID R01AI121147)
76. Infectious diseases, inflammaging and antibiotic use in elderly; critical appraisal of real-life practice
77. Inflamma-miRs, Mito-miRs, and SA-miRs: Are They at the Crossroads of inflammaging?
78. inflammaging
79. inflammaging
80. inflammaging Aging inflammatory origin
81. inflammaging and ‘Garb-aging‘
82. inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
83. inflammaging and anti-inflammaging: the role of cytokines in extreme longevity
84. inflammaging and cancer: a challenge for the Mediterranean diet
85. inflammaging and cardiovascular disease: Management by medicinal plants
86. inflammaging and frailty status do not result in an increased extracellular vesicle concentration in circulation
87. inflammaging and human longevity in the omics era
88. inflammaging and Its Role in Ageing and Age-Related Diseases
89. inflammaging and oxidative stress in human diseases: from molecular mechanisms to novel treatments
90. inflammaging and Presbycusis
91. inflammaging and proteases in abdominal aortic aneurysm
92. inflammaging and skeletal muscle: can protein intake make a difference?
93. inflammaging and the Lung
94. inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis
95. inflammaging as a major characteristic of old people: can it be prevented or cured?
96. inflammaging as a prodrome to Alzheimer’s disease
97. inflammaging at Ocular Surface: Clinical and Biomolecular Analyses in Healthy Volunteers
98. inflammaging decreases adaptive and innate immune responses in mice and humans
99. inflammaging decreases the human B cell response to the influenza vaccine (P4524)
100. inflammaging determines health and disease in lumbar discs—evidence from differing proteomic signatures of healthy, aging, and degenerating discs
101. inflammaging does not contribute to age-related changes in cardiac electrical activity
102. inflammaging impairs peripheral nerve maintenance and regeneration
103. inflammaging in cervical and lumbar degenerated intervertebral discs: analysis of proinflammatory cytokine and TRP channel expression
104. inflammaging in skin and other tissues-the roles of complement system and macrophage
105. inflammaging in the intervertebral disc
106. inflammaging increases susceptibility to cigarette smoke-induced COPD
107. inflammaging is associated with shifted macrophage ontogeny and polarization in the aging mouse ovary
108. inflammaging phenotype in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161 …
109. inflammaging Signaling in Health Span and Life Span Regulation: Next Generation Targets for Longevity
110. inflammaging-associated metabolic alterations foster development of the MDS genotype
111. inflammaging, metabolic syndrome and melatonin: a call for treatment studies
112. inflammaging: A Concept Analysis
113. inflammaging: a new immune–metabolic viewpoint for age-related diseases
114. inflammaging: age and systemic, cellular, and nuclear inflammatory biology in older adults
115. inflammaging: disturbed interplay between autophagy and inflammasomes
116. inflammaging: should this term be suitable for age related macular degeneration too?
117. inflammaging: the driving force in osteoporosis?
118. inflammaging.
119. Is inflammaging an auto [innate] immunity subclinical syndrome?
120. Is RAGE the receptor for inflammaging?
121. Lactobacillus pentosus var. plantarum C29 ameliorates memory impairment and inflammaging in a D-galactose-induced accelerated aging mouse model
122. Lifelong aerobic exercise protects against inflammaging and cancer
123. LINE-1 derepression in senescent cells triggers interferon and inflammaging
124. lncRNA-Triggered Macrophage inflammaging Deteriorates Age-Related Diseases
125. Matrix Metalloproteinases and Skin inflammaging
126. Mediterranean diet and inflammaging in the elderly: the European project NU-AGE. Preface.
127. Mediterranean diet and inflammaging within the hormesis paradigm
128. Melatonin and brain inflammaging
129. Metabolic alterations in aging macrophages: ingredients for inflammaging?
130. Microbiota and Xenobiotics Reveal Links between Myopathy, inflammaging and Glycolytic Metabolism
131. MicroRNA-34a: a new player in arterial inflammaging
132. MicroRNA-570 is a novel regulator of cellular senescence and inflammaging
133. MicroRNAs in Tfh cells: micromanaging inflammaging
134. MicroRNAs, T follicular helper cells and inflammaging
135. Microvasculature remodeling in the mouse lower gut during inflammaging
136. Mitochondrial (dys) function in inflammaging: do mitomiRs influence the energetic, oxidative, and inflammatory status of senescent cells?
137. Mitochondrial redox system, dynamics, and dysfunction in lung inflammaging and COPD
138. Molecular and cellular bases of immunosenescence, inflammation, and cardiovascular complications mimicking “inflammaging” in patients with systemic lupus …
139. Muscle inflammaging: The NLRP3 Inflammasome Contributes to Sarcopenia
140. Muscle wasting, dysfunction, and inflammaging
141. Myeloid-derived suppressor cells at the intersection of inflammaging and bone fragility
142. N-glycomic biomarkers of biological aging and longevity: a link with inflammaging
143. NAD+ DEPLETION AS A CAUSE OF inflammaging
144. NLRP3 inflammasome activation in inflammaging
145. Obesity, insulin resistance, and inflammaging
146. Oxidative stress, inflammaging, and immunosenescence
147. P3484 The acute inflammatory response in elderly STEMI patients leads to greater microvascular dysfunction? A new perspective on inflammaging
148. Particulate matter induces pro‐inflammatory cytokines via phosphorylation of p38 MAPK possibly leading to dermal inflammaging
149. Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence
150. Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice
151. Pyrroloquinoline quinone delays inflammaging induced by TNF‐α through the p16/p21 and Jagged1 signalling pathways
152. Rapamycin improves healthspan but not inflammaging in nfκb1−/− mice
153. Rcor2 underexpression in senescent mice: a target for inflammaging?
154. Re: Association of inflammaging (Inflammation+ Aging) with Higher Prevalence of OAB in Elderly Population
155. RECIPROCAL FUELLING OF GARBAGING/inflammaging AND CHRONIC AGE-RELATED DISEASES
156. Relationship between Circulating Protein p53 and High Sensitivity C-Reactive Protein in Central Obesity Men with inflammaging
157. Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation
158. RETINAL inflammaging: PATHOGENESIS AND PREVENTION
159. Ribosomal DNA instability: an evolutionary conserved fuel for inflammaging
160. Role of budesonide, formoterol fumarate and aclidinium bromide in the inflammaging of airway epithelial cells
161. Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD
162. Should we Try to Alleviate Immunosenescence and inflammaging-Why, How and to What Extent?
163. SIRT1 and inflammaging in Chronic Obstructive Pulmonary Disease
164. SIRT1 as a therapeutic target in inflammaging of the pulmonary disease
165. SO001 C1-INHIBITOR ABROGATED ISCHEMIA/REPERFUSION (I/R) INDUCED inflammaging BY INHIBITING SENESCENCE-ASSOCIATED SECRETORY …
166. Specific calpain inhibition protects kidney against inflammaging
167. Stress induced neuroendocrine-immune plasticity: A role for the spleen in peripheral inflammatory disease and inflammaging?
168. Stress related shift toward inflammaging in cosmonauts after long-duration space flight
169. Stress Response, inflammaging, and Cancer
170. Submandibular gland-specific inflammaging-induced hyposalivation in the male senescence-accelerated mouse prone-1 line (SAM-P1)
171. Systems medicine of inflammaging
172. T cell senescence and its correlation to inflammaging process of patients with systemic lupus erythematosus
173. Targeting vascular inflammaging with amlodipine for atherosclerosis prevention
174. The age‐related increase in low‐grade systemic inflammation (inflammaging) is not driven by cytomegalovirus infection
175. The association between inflammaging and age-related changes in the ruminal and fecal microbiota among lactating Holstein cows
176. The epigenetics of inflammaging: The contribution of age-related heterochromatin loss and locus-specific remodelling and the modulation by environmental …
177. The integration of inflammaging in age-related diseases
178. The link between inflammaging and degenerative joint diseases
179. THE NLRC4 INFLAMMASOME CONTRIBUTES TO BRAIN inflammaging
180. The potential role of necroptosis in inflammaging and aging
181. The pulmonary rehabilitation regimen: a treatment for frailty and ‘inflammaging‘?
182. The receptor for advanced glycation end-products (RAGE) is an important pattern recognition receptor (PRR) for inflammaging
183. The relation of inflammaging with skeletal muscle properties in elderly men
184. The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process
185. Tocotrienol‐rich fraction attenuates UV‐induced inflammaging: A bench to bedside study
186. Toll like receptor signaling in “inflammaging”: microRNA as new players
187. Tryptophan Metabolism in inflammaging: From Biomarker to Therapeutic Target
188. Understanding how we age: insights into inflammaging
189. Vitamin e-loaded membrane dialyzers reduce hemodialysis inflammaging
190. Young serum-derived exosomes potentially attenuate inflammaging via partially rejuvenating immuotolerance (Supported by NIH/NIAID R01AI121147 to DM. S.)