INSULIN & MTOR

/ DISEASE & DISORDERS, SCIENCE / By
  1. mTor‐dependent stimulation of the association of eIF4G and eIF3 by insulin
  2. insulin signalling to mTor mediated by the Akt/PKB substrate PRAS40
  3. The role of mammalian target of rapamycin (mTor) in insulin signaling
  4. Amino acid and insulin signaling via the mTor/p70 S6 kinase pathway: a negative feedback mechanism leading to insulin resistance in skeletal muscle cells
  5. The cardioprotection of the insulin-mediated PI3K/Akt/mTor signaling pathway
  6. Down‐regulation of placental mTor, insulin/IGF‐I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon
  7. Judicious toggling of mTor activity to combat insulin resistance and cancer: current evidence and perspectives
  8. Akt/mTor role in human foetoplacental vascular insulin resistance in diseases of pregnancy
  9. Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTor in isolated rat hepatocytes
  10. Activation of mammalian target of rapamycin (mTor) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTor complex 1
  11. Stimulation of the insulin/mTor pathway delays cone death in a mouse model of retinitis pigmentosa
  12. insulin activation of Rheb, a mediator of mTor/S6K/4E-BP signaling, is inhibited by TSC1 and 2
  13. MAP kinases and mTor mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632
  14. insulin and amino-acid regulation of mTor signaling and kinase activity through the Rheb GTPase
  15. Glycerolipid signals alter mTor complex 2 (mTorC2) to diminish insulin signaling
  16. Acute mTor inhibition induces insulin resistance and alters substrate utilization in vivo
  17. IKKβ suppression of TSC1 function links the mTor pathway with insulin resistance
  18. Chronic mTor inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats
  19. insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTor-NFκB-Opa-1 signaling pathway
  20. insulin-and leptin-mediated control of aquaglyceroporins in human adipocytes and hepatocytes is mediated via the PI3K/Akt/mTor signaling cascade
  21. Long‐chain omega‐3 fatty acids regulate bovine whole‐body protein metabolism by promoting muscle insulin signalling to the Akt–mTor–S6K1 pathway and insulin …
  22. Inappropriate activation of the TSC/Rheb/mTor/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
  23. Distinct signaling events downstream of mTor cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins
  24. insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTor and Rac1 signaling pathways
  25. Glucose phosphorylation is required for insulin-dependent mTor signalling in the heart
  26. Quantification of the effect of amino acids on an integrated mTor and insulin signaling pathway
  27. … 3-kinase/Akt/mTor pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
  28. Adipocyte-specific deletion of mTor inhibits adipose tissue development and causes insulin resistance in mice
  29. Mammalian target of rapamycin (mTor) is involved in the neuronal differentiation of neural progenitors induced by insulin
  30. mTorC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTor
  31. Activation of mTor/p70S6 kinase by ANG II inhibits insulin-stimulated endothelial nitric oxide synthase and vasodilation
  32. Protein ingestion induces muscle insulin resistance independent of leucine-mediated mTor activation
  33. Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTor/S6K1 and AMPK pathways
  34. The PI3K/Akt/mTor signaling pathway mediates insulin-like growth factor 1-induced E-cadherin down-regulation and cell proliferation in ovarian cancer cells
  35. Longevity pathways (mTor, SIRT, insulin/IGF-1) as key modulatory targets on aging and neurodegeneration
  36. The TSC-mTor pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor-or rictor-independent manner
  37. Amino acids are necessary for the insulin-induced activation of mTor/S6K1 signaling and protein synthesis in healthy and insulin resistant human skeletal muscle
  38. Genetically reducing mTor signaling rescues central insulin dysregulation in a mouse model of Alzheimer’s disease
  39. The insulin-like growth factor-I–mTor signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth
  40. mTor complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8
  41. insulin-like growth factor II targets the mTor pathway to reverse autism-like phenotypes in mice
  42. mTor inhibition with rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes
  43. Hepatitis C virus activates the mTor/S6K1 signaling pathway in inhibiting IRS-1 function for insulin resistance
  44. Activation of placental insulin and mTor signaling in a mouse model of maternal obesity associated with fetal overgrowth
  45. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTor-mediated insulin receptor substrate 1 phosphorylation
  46. mTor and neuronal cell cycle reentry: how impaired brain insulin signaling promotes Alzheimer’s disease
  47. Zinc stimulates the activity of the insulin-and nutrient-regulated protein kinase mTor
  48. insulin growth factor-receptor (IGF-1R) antibody cixutumumab combined with the mTor inhibitor temsirolimus in patients with refractory Ewing’s sarcoma family …
  49. Exercise training reduces insulin resistance and upregulates the mTor/p70S6k pathway in cardiac muscle of diet‐induced obesity rats
  50. insulin-and lipopolysaccharide-mediated signaling in adipose tissue macrophages regulates postprandial glycemia through akt-mTor activation
  51. Maternal protein restriction in the rat inhibits placental insulin, mTor, and STAT3 signaling and down-regulates placental amino acid transporters
  52. Glucose induces mouse β-cell proliferation via IRS2, mTor, and cyclin D2 but not the insulin receptor
  53. hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTor signaling
  54. Effects of insulin and pathway inhibitors on the PI3K-Akt-mTor phosphorylation profile in acute myeloid leukemia cells
  55. Statins activate the NLRP3 inflammasome and impair insulin signaling via p38 and mTor
  56. Enhanced skeletal muscle insulin sensitivity after acute resistance-type exercise is upregulated by rapamycin-sensitive mTor complex 1 inhibition
  57. Excitotoxic glutamate causes neuronal insulin resistance by inhibiting insulin receptor/Akt/mTor pathway
  58. Overexpression of kinase-dead mTor impairs glucose homeostasis by regulating insulin secretion and not β-cell mass
  59. Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTor/p70 S6K pathway
  60. insulin growth factor receptor (IGF-1R) antibody cixutumumab combined with the mTor inhibitor temsirolimus in patients with metastatic adrenocortical …
  61. Role of the PI3-kinase/mTor pathway in the regulation of the stearoyl CoA desaturase (SCD1) gene expression by insulin in liver
  62. Inhibition of the mTor/p70S6K pathway is not involved in the insulin-sensitizing effect of AMPK on cardiac glucose uptake
  63. insulin-like growth factor I-mediated skeletal muscle hypertrophy is characterized by increased mTor-p70S6K signaling without increased Akt phosphorylation
  64. Mammalian target of rapamycin (mTor) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute …
  65. A novel voluntary weightlifting model in mice promotes muscle adaptation and insulin sensitivity with simultaneous enhancement of autophagy and mTor pathway
  66. Mechanistic target of rapamycin (mTor): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer …
  67. insulin promotes glucose consumption via regulation of miR-99a/mTor/PKM2 pathway
  68. Salmonella enterica Typhimurium infection causes metabolic changes in chicken muscle involving AMPK, fatty acid and insulin/mTor signaling
  69. Systematic Screen for Drosophila Transcriptional Regulators Phosphorylated in Response to insulin/mTor Pathway
  70. insulin and mTor pathway regulate HDAC3-mediated deacetylation and activation of PGK1
  71. The role of AMPK/mTor/S6K1 signaling axis in mediating the physiological process of exercise-induced insulin sensitization in skeletal muscle of C57BL/6 …
  72. The regulation of lipid deposition by insulin in goose liver cells is mediated by the PI3K-AKT-mTor signaling pathway
  73. Amino acids and leucine allow insulin activation of the PKB/mTor pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice
  74. Anthocyanin-rich mulberry fruit improves insulin resistance and protects hepatocytes against oxidative stress during hyperglycemia by regulating AMPK/ACC/mTor …
  75. Both Wnt and mTor signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells
  76. Palmitate induced insulin resistance by PKCtheta-dependent activation of mTor/S6K pathway in C2C12 myotubes
  77. insulin-like peptides and the mTor-TFEB pathway protect Caenorhabditis elegans hermaphrodites from mating-induced death
  78. PKCζ is essential for pancreatic β-cell replication during insulin resistance by regulating mTor and cyclin-D2
  79. Akt/mTor Counteract the Antitumor Activities of Cixutumumab, an Anti-insulin–like Growth Factor I Receptor Monoclonal Antibody
  80. insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K …
  81. mTor-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1
  82. Leucine activates pancreatic translational machinery in rats and mice through mTor independently of CCK and insulin
  83. insulin regulates titin pre-mRNA splicing through the PI3K-Akt-mTor kinase axis in a RBM20-dependent manner
  84. insulin fails to enhance mTor phosphorylation, mitochondrial protein synthesis, and ATP production in human skeletal muscle without amino acid replacement
  85. insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTor)-induced negative feedback down-regulates …
  86. Exercise and dietary change ameliorate high fat diet induced obesity and insulin resistance via mTor signaling pathway
  87. insulin-induced de novo lipid synthesis occurs mainly via mTor-dependent regulation of proteostasis of SREBP-1c
  88. Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTor and rictor
  89. … a model describing regulation of casein synthesis by the mammalian target of rapamycin (mTor) signaling pathway in response to insulin, amino acids, and …
  90. … hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTor) and c-Jun N-terminal kinase/insulin receptor substrate 1 …
  91. Antiproliferation of cardamonin is involved in mTor on aortic smooth muscle cells in high fructose-induced insulin resistance rats
  92. THE ROLE OF AMPK AND mTor IN THE DEVELOPMENTOF insulin RESISTANCE AND TYPE 2 DIABETES. THE MECHANISM OF METFORMIN ACTION …
  93. Nanocurcumin alleviates insulin resistance and pancreatic deficits in polycystic ovary syndrome rats: Insights on PI3K/AkT/mTor and TNF-α modulations
  94. insulin stimulates goose liver cell growth by activating PI3K-AKT-mTor signal pathway
  95. insulin-like growth factor 1 receptor-mediated cell survival in hypoxia depends on the promotion of autophagy via suppression of the PI3K/Akt/mTor signaling …
  96. Zinc stimulates glucose consumption by modulating the insulin signaling pathway in L6 myotubes: essential roles of Akt–GLUT4, GSK3β and mTor–S6K1
  97. Leucine stimulates insulin secretion via down-regulation of surface expression of adrenergic α2A receptor through the mTor (mammalian target of rapamycin …
  98. Activation of the PI3K/Akt/mTor/p70S6K1 signaling cascade in the mononuclear cells of peripheral blood: association with insulin and insulin-like growth factor levels …
  99. Effective amelioration of hepatic inflammation and insulin response in high fat diet-fed rats via regulating AKT/mTor signaling: Role of Lepidium sativum seed extracts
  100. 17β-estradiol regulates glucose metabolism and insulin secretion in rat islet β cells through GPER and Akt/mTor/GLUT2 pathway
  101. Therapeutic effects of organic zinc on reproductive hormones, insulin resistance and mTor expression, as a novel component, in a rat model of Polycystic …
  102. Cardamonin ameliorates insulin resistance induced by high insulin and high glucose through the mTor and signal pathway
  103. Inhibiting insulin and mTor signaling by afatinib and crizotinib combination fosters broad cytotoxic effects in cutaneous malignant melanoma
  104. Implication of RICTOR in the mTor inhibitor-mediated induction of insulin-like growth factor-I receptor (IGF-IR) and human epidermal growth factor receptor-2 …
  105. Humanin attenuates palmitate-induced hepatic lipid accumulation and insulin resistance via AMPK-mediated suppression of the mTor pathway
  106. … of insulin-like growth factor 1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction but not hypertrophy: roles of Akt, mTor, GSK3β, and PTEN
  107. insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTor: studies on the function of Ser675 and Ser907
  108. Pectic bee pollen polysaccharide from Rosa rugosa alleviates diet-induced hepatic steatosis and insulin resistance via induction of AMPK/mTor-mediated autophagy
  109. Evodiamine inhibits insulin-stimulated mTor-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese …
  110. … improves vascular endothelial dysfunction by inducing autophagy via AMPK/mTor signaling activation in a rat model of type 2 diabetes mellitus with insulin …
  111. The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTor) complex 1 and its contribution to mTor complex 1 …
  112. … a low-protein diet in utero demonstrate changes in mTor signaling in pancreatic islets of langerhans, associated with altered glucagon and insulin expression and a …
  113. insulin-induced stimulation of JNK and the PI 3-kinase/mTor pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes
  114. insulin‐like growth factor‐1 (IGF‐1) and leucine activate pig myogenic satellite cells through mammalian target of rapamycin (mTor) pathway
  115. Galangin and pinocembrin from propolis ameliorate insulin resistance in HepG2 cells via regulating Akt/mTor signaling
  116. insulin Potentiates Ca2+ Signaling and Phosphatidylinositol 4,5-Bisphosphate Hydrolysis Induced by Gq Protein-Coupled Receptor Agonists through an mTor …
  117. Hexanoic, octanoic and decanoic acids promote basal and insulin-induced phosphorylation of the Akt-mTor axis and a balanced lipid metabolism in the HepG2 …
  118. … lychee fruit extract alleviates diet‐induced insulin resistance via suppressing mTor/SREBP‐1 mediated lipogenesis in liver and restoring insulin signaling in skeletal …
  119. insulin-like growth factor-I inhibits dexamethasone-induced proteolysis in cultured L6 myotubes through PI3K/Akt/GSK-3β and PI3K/Akt/mTor-dependent …
  120. Amino acid-and insulin-induced activation of mTorC1 in neonatal piglet skeletal muscle involves Sestrin2-GATOR2, Rag A/C-mTor, and RHEB-mTor complex …
  121. The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTor inhibitor-mediated antitumor efficacy in hepatocellular carcinoma
  122. insulin-like growth factor 1-receptor signaling stimulates GRP78 expression through the PI3K/AKT/mTor/ATF4 axis
  123. Tissue-specific responses of IGF-1/insulin and mTor signaling in calorie restricted rats
  124. Improved insulin sensitivity by rapamycin is associated with reduction of mTor and S6K1 activities in L6 myotubes
  125. Scutellarin, a modulator of mTor, attenuates hepatic insulin resistance by regulating hepatocyte lipid metabolism via SREBP‐1c suppression
  126. Rumen-Protected Glucose Stimulates the insulin-Like Growth Factor System and mTor/AKT Pathway in the Endometrium of Early Postpartum Dairy Cows
  127. Knockdown of insulin receptor substrate 1 reduces proliferation and downregulates Akt/mTor and MAPK pathways in K562 cells
  128. Intranasal insulin increases synaptic protein expression and prevents anesthesia-induced cognitive deficits through mTor-eEF2 pathway
  129. insulin increases sestrin 2 content by reducing Its degradation through the PI3K/mTor signaling pathway
  130. … acid stimulates energy metabolism and inhibits insulin/PI3K/AKT signaling in differentiated human neuroblastoma cells: The role of mTor activation and mitochondrial …
  131. Rosemary Extract Activates AMPK, Inhibits mTor and Attenuates the High Glucose and High insulin-Induced Muscle Cell insulin Resistance
  132. … Protein Kinase IV (CaMKIV) limits ER stress and improves insulin sensitivity through inhibition of autophagy via the mTor/CREB signaling pathway
  133. Adipocyte-specific DKO of Lkb1 and mTor protects mice against HFD-induced obesity, but results in insulin resistance
  134. Impaired overload-induced hypertrophy is associated with diminished mTor signaling in insulin-resistant skeletal muscle of the obese Zucker rat
  135. The inhibition of insulin-stimulated proliferation of vascular smooth muscle cells by rosiglitazone is mediated by the Akt-mTor-P70S6K pathway
  136. … the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTor
  137. insulin increases cholesterol uptake, lipid droplet content, and apolipoprotein B secretion in CaCo‐2 cells by upregulating SR‐BI via a PI3K, AKT, and mTor …
  138. mTor partly mediates insulin resistance by phosphorylation of insulin receptor substrate-1 on serine307 residues after burn
  139. mTor inhibition: reduced insulin secretion and sensitivity in a rat model of metabolic syndrome
  140. insulin-like growth factor I suppresses bone morphogenetic protein signaling in prostate cancer cells by activating mTor signaling
  141. Effect of electrical stimulation combined with diet therapy on insulin resistance via mTor signaling
  142. insulin-stimulated mTor activation in peripheral blood mononuclear cells associated with early treatment response to lithium augmentation in rodent model of …
  143. … of Free Fatty Acid (FFA)-Induced Skeletal Muscle Cell insulin Resistance by Resveratrol is Linked to Activation of AMPK and Inhibition of mTor and p70 S6K
  144. 4-PBA reverses autophagic dysfunction and improves insulin sensitivity in adipose tissue of obese mice via Akt/mTor signaling
  145. PRAS40 deregulates apoptosis in Ewing sarcoma family tumors by enhancing the insulin receptor/Akt and mTor signaling pathways
  146. … , methionine, threonine, and other amino acids on insulin and glucagon concentrations, mammalian target of rapamycin (mTor) signaling, and lactational …
  147. Anti-inflammatory action of insulin via induction of Gadd45-β transcription by the mTor signaling pathway
  148. Effects of dietary oxidized tyrosine products on insulin secretion via the thyroid hormone T3-regulated TRβ1–Akt–mTor pathway in the pancreas
  149. insulin inhibition of apolipoprotein B mRNA translation is mediated via the PI-3 kinase/mTor signaling cascade but does not involve internal ribosomal entry site …
  150. Exercise improves skeletal muscle insulin resistance without reduced basal mTor/S6K1 signaling in rats fed a high-fat diet
  151. Essential amino acids improve insulin activation of AKT/mTor signaling in soleus muscle of aged rats
  152. Reduction of insulin signalling pathway IRS‐1/IRS‐2/AKT/mTor and decrease of epithelial cell proliferation in the prostate of glucocorticoid‐treated rats
  153. Regulation of skeletal muscle insulin-stimulated signaling through the MEK-REDD1-mTor axis
  154. Attenuation of insulin resistance in rats by agmatine: role of SREBP-1c, mTor and GLUT-2
  155. insulin-Like Growth Factor Binding Protein-Related Protein 1 Activates Primary Hepatic Stellate Cells via Autophagy Regulated by the PI3K/Akt/mTor …
  156. Medium-chain triacylglycerol suppresses the decrease of plasma albumin level through the insulin-Akt-mTor pathway in the livers of malnourished rats
  157. Amino acid-sensing mTor signaling is involved in modulation of lipolysis by chronic insulin treatment in adipocytes
  158. insulin stimulates IGFBP-2 expression in 3T3-L1 adipocytes through the PI3K/mTor pathway
  159. Melanocortin-4 receptor activation promotes insulin-stimulated mTor signaling
  160. insulin activation of vacuolar protein sorting 34 mediates localized phosphatidylinositol 3-phosphate production at lamellipodia and activation of mTor/S6K1
  161. … and autophagy of articular chondrocytes via modulating the phosphoinositide 3‐kinase/protein kinase B‐mTor pathway by targeting insulin‐like growth factor‐1
  162. Crosstalk with insulin and dependence on PI3K/Akt/mTor rather than MAPK pathways in upregulation of basal growth following long-term oestrogen …
  163. Effects of resveratrol, lovastatin and the mTor-inhibitor RAD-001 on insulin-induced genomic damage in vitro
  164. Eicosapentaenoic acid abolishes inhibition of insulin-induced mTor phosphorylation by LPS via PTP1B downregulation in skeletal muscle
  165. insulin regulation of hepatic insulin-like growth factor-binding protein-1 (IGFBP-1) gene expression and mammalian target of rapamycin (mTor) signalling is impaired …
  166. The effects of amino acids on glucose metabolism of isolated rat skeletal muscle are independent of insulin and the mTor/S6K pathway
  167. Combination of the mammalian target of rapamycin (mTor) inhibitor everolimus (E) with the insulin like growth factor-1-receptor (IGF-1-R) inhibitor NVP-AEW-541: A …
  168. miR-155-5p alleviates ethanol-induced myocardial insulin resistance in H9C2 cells via regulating the mTor signalling pathway
  169. Transcription factor-7–like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTor signaling, β cell growth, and insulin secretion
  170. Preoperative oral carbohydrate improved postoperative insulin resistance in Rats through the PI3K/AKT/mTor pathway
  171. insulin-induced mTor activity exhibits anti-hepatitis C virus activity
  172. In human endothelial cells amino acids inhibit insulin-induced Akt and ERK1/2 phosphorylation by an mTor-dependent mechanism
  173. miR‐483 is d ownregulated in pre‐eclampsia via targeting insulin‐like growth factor 1 (IGF1) and regulates the PI3K/Akt/mTor pathway of endothelial progenitor cells
  174. 1, 25 (OH) 2D3 protects trophoblasts against insulin resistance and inflammation via suppressing mTor signaling
  175. Inhibition of PI-3 kinase/Akt/mTor, but not calcineurin signaling, reverses insulin-like growth factor I-induced protection against glucose toxicity in …
  176. insulin-like growth factor binding protein-3 mediates interleukin-24-induced apoptosis through inhibition of the mTor pathway in prostate cancer
  177. Effect of AMPK/mTor/S6K1 pathways and the insulin-sensitizing effect for adiponectin in endometrial cancer cells
  178. Modeling the effects of insulin and amino acids on the phosphorylation of mTor, Akt, and 4EBP1 in mammary cells
  179. Correction: insulin and mTor pathway regulate HDAC3-mediated deacetylation and activation of PGK1
  180. Bromodomain-containing protein 2 induces insulin resistance via the mTor/Akt signaling pathway and an inflammatory response in adipose tissue
  181. Involvement of mTor in type 2 CRF receptor inhibition of insulin signaling in muscle cells
  182. … pathway leads to phosphorylation of IRS-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mTor insulin biosynthetic pathway in RIN …
  183. Anti-insulin-like growth factor-1 receptor (IGF-1R) monoclonal antibody cixutumumab (cix) plus mTor inhibitor temsirolimus (tem) in metastatic castration-resistant …
  184. Heparin-binding EGF-like growth factor (HB-EGF) mediates 5-HT-induced insulin resistance through activation of EGF receptor-ERK1/2-mTor pathway
  185. Branched-Chain α-Ketoacids Regulate insulin and mTor Signalling in Skeletal and Cardiac Muscle
  186. 2313-PUB: Alterations in Basal State of insulin and mTor-Dependent Signalings Closely Related to Impaired Incretin Profile and Type 2 Diabetes in Subcutaneous …
  187. SDC3 acts as a timekeeper of myogenic differentiation by regulating the insulin/AKT/mTor axis in muscle stem cell progeny
  188. insulin promotes the expression of the gluconeogenic rate-limiting enzymes phosphoenolpyruvate carboxykinase (Pepck) and glucose 6-phosphatase …
  189. Forskolin attenuates the action of insulin on the Akt–mTor pathway in human skeletal muscle
  190. Anti-insulin-like growth factor-1 receptor (IGF-IR) monoclonal antibody cixutumumab plus mammalian target of rapamycin (mTor) inhibitor temsirolimus in metastatic …
  191. The relationship between mTor/S6K1 signaling pathway and insulin resistance and the study of aerobic exercise on this pathway
  192. Bifurcation analysis of insulin regulated mTor signalling pathway in cancer cells
  193. Effects of insulin on Milk Fat Synthesis by Regulating the Expressions of SREBP1 and mTor in Bovine Mammary Epithelial Cells.
  194. … Holstein male calves accelerated by branched-chain volatile fatty acids addition with up-regulated hepatic mTor expression via insulin and insulin-like growth factor …
  195. … Acid-and insulin-Induced Activation of Mechanistic Target of Rapamycin Complex 1 in Neonatal Piglet Skeletal Muscle Involves Sestin2-GATOR2, Rag A/C-mTor …
  196. insulin Stimulation of Protein Synthesis and mTor Signaling in Chick Myotube Cultures
  197. Effects of dietary oxidized tyrosine products on insulin secretion via the thyroid hormone T3-regulated TRb1–Akt–mTor pathway in the pancreas
  198. Comment on Smith et al. Protein ingestion induces muscle insulin resistance independent of leucine-mediated mTor activation. Diabetes 2015; 64: 1555 …
  199. insulin Confers Neuroprotection Against Hyperglycemic Stress-Induced Apoptosis Through PI3K/Akt/mTor/Nrf2/GCL/Redox Signaling.
  200. Molecular mechanism of insulin resistance: role of mTor signaling pathways
  201. Activation of the PI3K/Akt/mTor Pathway by insulin Is Crucial for Amplification of FSH-Induced Differentiation, but Not Proliferation, of Ovarian Granulosa Cells.
  202. Analysis of Integrated insulin–mTor Signalling Network-Diabetes Perspective
  203. The ageing process: insulin signalling and mTor signalling
  204. Fish Oil and Cardiac Akt/mTor-Mediated insulin Resistance in Infants with Maternal Diabetes
  205. … carbohydrate and branched-chain amino acids on markers of skeletal muscle protein synthesis of the insulin-PI3K-mTor signal transduction pathways in …
  206. Effects of α-ketoglutarate on Plasma Concentrations of insulin and Amino Acids and mTor Signal Transduction in Gastrocnemius of Piglets Challenged by …
  207. The Effect of insulin-like Growth Factor 1 (IGF-1) and Exercise on the Protein Expression of Mammalian Target of Rapamycin (mTor) and Androgen Receptor (AR) in …
  208. Agpat1 Decreases insulin Signaling by Activating the mTor Pathway.
  209. The insulin/IGF-1, the sirtuin and the mTor pathway. How alterations of these pathways could affect age-related diseases and lifespan.
  210. … giant cell tumor with benign histologic features, treated with SCH 717–454, an insulin growth factor receptor inhibitor, in combination with everolimus, an mTor …
  211. insulin Stimulates mTor Phosphorylation via Protein Klnase B
  212. Evaluation of combined insulin-like growth factor type 1 (IGF1R) and mTor pathway blockade in sarcoma xenograft models
  213. Effect of combined treatment with insulin, metformin, and gliclazide on the expression and activity of Akt, mTor, and p70S6K protein kinases in lymphocytes of …
  214. Calcium/calmodulin-dependent Protein Kinase IV Limits ER stress and insulin Resistance through Inhibition of Autophagy in Adipocytes by mTor/CREB Signaling
  215. Research progress of inhibitors in mTor and insulin/IGF-1 signaling pathway and age-related diseases
  216. Retraction: insulin-Like Growth Factor I Suppresses Bone Morphogenetic Protein Signaling in Prostate Cancer Cells by Activating mTor Signaling
  217. mTor kinase activity is required by the myocardium for basal level and insulin‐induced mTor‐mediated signals
  218. Actions of insulin As a Survival and Growth Factor: Akt, mTor, and Regulation of Translation
  219. Hypothalamic mTor pathway mediates neuronal actions of insulin
  220. … -Protein Diet in Utero Demonstrate Changes in mTor Signaling in Pancreatic Islets of Langerhans, Associated with Altered Glucagon and insulin Expression and a …
  221. A high fat diet induces insulin resistance and insulin-independent activation of the mTor-S6 kinase pathway in mouse liver
  222. Insights into insulin-mediated regulation of CYP2E1: miR 132/212 targeting of CYP2E1 and role of PI3-K, Akt, mTor signaling in regulating miR132/212 and miR 122 …
  223. The effect of mTor/S6K1 signaling pathway on the development of high fat diet-induced mouse insulin resistance
  224. insulin-mediated regulation of the miR132/212 cluster and miR 122/181a expression through PI3K, Akt, mTor signaling in primary cultured rat hepatocytes.
  225. A Dual PI3K-mTor Inhibitor Induced Hyperglycemia and Increased insulin Signals in the Heart
  226. mTor Signaling Pathway Regulates insulin-Induced Redistribution and Degradation of IRS-1 in 3T3-L1 Adipocytes
  227. Targeting the insulin-like growth factor 1 (IGF1R) and insulin (IR) receptor with a dual IGF1R/IR inhibitor, OSI-906, to potentiate mTor inhibitor effects in experimental …
  228. insulin-Mediated Down-Regulation of the Anti-Angiogenic Protein PEDF is mTor Dependent.
  229. Hepatic Overexpression of Dominant Negative Form of mTor Enhances Akt Phosphorylation and Restores insulin Resistance in K/KAy Mice.
  230. The regulation of skeletal muscle insulin‐stimulated signaling by the MEK‐REDD1‐mTor axis
  231. Abstract A56: A dual PI3K-mTor inhibitor induced cardiac hypertrophy in mice: Role of the insulin signaling
  232. The role of PRAS40 in insulin action: at the intersection of protein kinase B (PKB/Akt) and mamalian target of rapamyein (mTor)
  233. Human postprandial blood concentrations of leucine and insulin increase phosphorylation of mTor in C2C12 myoblasts
  234. insulin stimulates muscle protein synthesis in neonates during endotoxemia despite suppression of insulin-stimulated mTor-dependent translation initiation
  235. Role of PRAS40 in mammalian target of rapamycin (mTor) modulation in cancer and insulin resistance
  236. PI3K-mTor Axis is a Critical Node for Hypothalamic insulin Receptor Signaling and Sympathetic Activation Induced by insulin
  237. insulin Resistance Suppresses Cardiac Autophagy Through the AMPK/mTor Pathway in Type 2 Diabetes
  238. Towards a mechanistic explanation of insulin resistance, which incorporates mTor, autophagy, and mitochondrial dysfunction
  239. A study on the relationship of mTor/S6K1 signaling pathway and aerobic exercises attenuating insulin resistance induced by high fat diet in mice
  240. … of heavy resistance exercise in combination with orally administered branched-chain amino acids or leucine on insulin signaling and Akt/mTor pathway activity in …
  241. # 11 insulin-like growth factor-I promotes myogenesis via both mTor-dependent and-independent pathways
  242. … derived from hR1, a humanized anti-insulin-like growth factor receptor-I monoclonal antibody, are enhanced in renal cell carcinoma and synergistic with an mTor …
  243. Supplemental Data Inappropriate Activation of the TSC/Rheb/mTor/S6K Cassette Induces IRS1/2 Depletion, insulin Resistance, and Cell Survival Deficiencies
  244. Activity of insulin growth factor-receptor (IGF-1R) antibody cixutumumab combined with the mTor inhibitor temsirolimus in patients with metastatic refractory …
  245. Abstract P5-11-06: Combination of insulin-like growth factor 1 receptor and PI3K/mTor inhibition in triple-negative breast cancers
  246. PO-063 Exercise alleviates insulin resistance by regulating MG53 and IR/IRS/AKT/mTor signaling in db/db mice skeletal muscle
  247. … Michael McDaniel, Ph. D., professor of pathology and immunology, wants to use this ability to makes cells divide and maintain enough insulin-making beta cells …
  248. insulin-like Growth Factor-I Suppresses Bone Morphogenetic Protein Signaling through a Phosphatidylinositol 3-Kinase, Akt and mTor-Dependant Mechanism
  249. insulin-Like Growth Factor Binding Protein (IGFBP) 3 Suppresses HIF1a Expression in Cancer Cells through Reactivating mTor/Tln Pathway
  250. Fasting and refeeding regulate in different manner SNAT 2, SREBP‐1 and 2, mTor, serum insulin in animals fed different types of protein
  251. … tyrosine kinase inhibitor for focal adhesion kinase and insulin-like growth factor-I receptor (TAE226) leads to apoptosis in esophageal cancer by inhibiting AKT-mTor …
  252. Abstract LB-124: insulin growth factor-receptor (IGF-1R) antibody cixutumumab combined with the mTor inhibitor temsirolimus in patients with refractory Ewing’s …
  253. EFFECTS OF DISRUPTING insulin-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-1R) SIGNAL TRANSDUCTION PATHWAYS WITH INHIBITORS OF IGF-1R …
  254. Impact of obesity on MMTV-Wnt-1 mammary cancer: role of the insulin-like growth factor-1 (IGF-1)/Akt/mTor pathway
  255. PI 3-Kinase and mTor Are Required for insulin Induced Phosphorylation of Eukaryotic Initiation Factor 4E Binding Protein 1 (4E-BP1) in Proximal Tubular Epithelial …
  256. Correction: Transcription factor-7–like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTor signaling, β cell growth, and insulin secretion.
  257. Impact of Obesity on MMTV-Wnt-1 Mammary Cancer: Role of The insulin-Like Growth Factor-1 (IGF-1)/Akt/mTor Pathway
  258. … 3900: Resveratrol suppresses insulin-like growth factor-1 promoted colon cancer cell growth via activation of p53/AMPK/TSC-2 and suppression of IGF-1R/Akt/mTor …

Related Posts

Shopping Cart
Scroll to Top