JNK PREVENTS PREMATURE SENESCENCE

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Prevention of premature senescence requires JNK activation

Premature senescence is considered as a cellular defense mechanism to prevent tumorigenesis. Although recent evidences show that c-Jun N-terminal kinase (JNK) is involved in the senescence process, the mechanism for this regulation is not fully understood. Here, we examined the role of JNK in premature senescence of tumor cells. Treatment of cells with the JNK-specific inhibitor SP600125 caused phenotypical changes of senescence and triggered a rapid increase in mitochondrial reactive oxygen species (ROS) production and DNA-damage response (DDR) in MCF7 breast carcinoma cells. ROS generation was attributed to the suppression of B-cell lymphoma-2 (Bcl-2) phosphorylation, and resulted in DNA damage and p53 activation. Bax did not change their localization to the mitochondria, which is required for apoptosis. The essential roles of JNK and phosphorylated Bcl-2 in preventing premature senescence were confirmed using RNA interference and ectopic expression of mutants of Bcl-2, including phosphomimetic and nonphosphorylatable forms. These findings were evidenced in H460 lung carcinoma cells and primary human embryonic fibroblasts. Altogether, our results showed that loss of JNK activity triggers a Bcl-2/ROS/DDR signaling cascade that ultimately leads to premature senescence, indicating that basal JNK activity is essential in preventing premature senescence.

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  4. A Dipeptidyl Peptidase-Iv Inhibitor Improves Hepatic Steatosis And Insulin Resistance By Ampk-Dependent And JNK-Dependent Inhibition Of Lect2 Expression
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  8. A Phospholipase D2 Inhibitor, Cay10594, Ameliorates Acetaminophen-Induced Acute Liver Injury By Regulating The Phosphorylated-Gsk-3Β/JNK Axis
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  19. Activation Of C-Jun Nh2-Terminal Kinase (JNK) Pathway During Islet Transplantation And Prevention Of Islet Graft Loss By Intraportal Injection Of JNK Inhibitor
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  30. Anti-Inflammatory Effect Of Sulforaphane On Lps-Activated Microglia Potentially Through JNK/Ap-1/Nf-Κb Inhibition And Nrf2/Ho-1 Activation
  31. Anti-Inflammatory Effects Of Ang-(1–7) Via Tlr4-Mediated Inhibition Of The JNK/Foxo1 Pathway In Lipopolysaccharide-Stimulated Raw264. 7 Cells
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  33. Antiproliferative And Proapoptotic Effect Of The Mlk/JNK Inhibitor Cep-1347 In Hepatocellular Carcinoma
  34. Apamin Attenuated Cerulein-Induced Acute Pancreatitis By Inhibition Of JNK Pathway In Mice
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  36. Arsenic Inhibits Neurofilament Transport And Induces Perikaryal Accumulation Of Phosphorylated Neurofilaments: Roles Of JNK And Gsk-3Β
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  39. As601245, An Anti-Inflammatory JNK Inhibitor, Strengthens The Effects Of Clofibrate And Affects Gene Expression Profile, In Caco-2 Colon Cancer Cells
  40. At-101, A Small Molecule Inhibitor Of Anti-Apoptotic Bcl-2 Family Members, Activates The Sapk/JNK Pathway And Enhances Radiation-Induced Apoptosis
  41. Attenuation Of Astrocyte Activation By Tat-Mediated Delivery Of A Peptide JNK Inhibitor
  42. Autophagy Attenuates The Catabolic Effect During Inflammatory Conditions In Nucleus Pulposus Cells, As Sustained By Nf-Κb And JNK Inhibition
  43. Baicalein Protects Cardiomyocytes Against Mitochondrial Oxidant Injury Associated With JNK Inhibition And Mitochondrial Akt Activation
  44. Bcl2 Inhibitor Abt-199 And JNK Inhibitor Sp600125 Exhibit Synergistic Cytotoxicity Against Imatinib-Resistant Ph+ All Cells
  45. Bentamapimod (JNK Inhibitor As602801) Induces Regression Of Endometriotic Lesions In Animal Models
  46. Block-Copolymer Micelles As Carriers Of Cell Signaling Modulators For The Inhibition Of JNK In Human Islets Of Langerhans
  47. Braf Inhibitors Suppress Apoptosis Through Off-Target Inhibition Of JNK Signaling
  48. Butylphthalide Suppresses Neuronal Cells Apoptosis And Inhibits JNK–Caspase3 Signaling Pathway After Brain Ischemia/Reperfusion In Rats
  49. C29 Protectors Of The Lung: Innate Immune Responses In Acute Lung Injury: Lipoteichoic Acid Upregulates Plasminogen Activator Inhibitor-1 …
  50. C38 Understanding Therapeutics In Ipf: Cc-90001, A Second Generation Jun N-Terminal Kinase (JNK) Inhibitor For The Treatment Of Idiopathic Pulmonary …
  51. Cardiac Macrophage Migration Inhibitory Factor Inhibits JNK Pathway Activation And Injury During Ischemia/Reperfusion
  52. Cardioprotective 3′, 4′-Dihydroxyflavonol Attenuation Of JNK And P38Mapk Signalling Involves Camkii Inhibition
  53. Cc-90001, A Second Generation Jun N-Terminal Kinase (JNK) Inhibitor For The Treatment Of Idiopathic Pulmonary Fibrosis
  54. Cell Biology – Immunology – Pathology Activation Of Erk Or Inhibition Of JNK Ameliorates H2O2 Cytotoxicity In Mouse Renal Proximal Tubule Cells.
  55. Cell Permeable Peptide Of JNK Inhibitor Prevents Islet Apoptosis Immediately After Isolation And Improves Islet Graft Function
  56. Cep-1347 Inhibits Caerulein-Induced Rat Pancreatic JNK Activation And Ameliorates Caerulein Pancreatitis
  57. Chaetocin-Induced Ros-Mediated Apoptosis Involves Atm–Yap1 Axis And JNK-Dependent Inhibition Of Glucose Metabolism
  58. Chaetoglobosin K, A Dual Akt And JNK Inhibitor, Modulates Akt Phosphorylation In An Mtorc2 Independent Manner
  59. Cisplatin Induces Autophagy To Enhance Hepatitis B Virus Replication Via Activation Of Ros/JNK And Inhibition Of The Akt/Mtor Pathway
  60. C-Jun N-Terminal Kinase (JNK) Inhibitor, Sp600125, Blocks Interleukin (Il)–6-Induced Vascular Endothelial Growth Factor (Vegf) Production: Cyclosporine A Partially …
  61. C-Jun N-Terminal Kinase (JNK) Mediated Inhibition Of Pyruvate Dehydrogenase (Pdh) Activity And Its Effect On Mitochondrial Metabolism During Brain Aging
  62. Co-Inhibition Of Nf-Κb And JNK Is Synergistic In Tnf-Expressing Human Aml
  63. Combination Of Hyperbaric Oxygenation And Selective JNK-Inhibition By D-JNK-I-1 As A Potent Neuroprotective Strategy In A Focal Ischaemia/Reperfusion Injury Model In …
  64. Combinatorial Effect Of Statins And JNK Inhibitor On Proinflammatory Signaling In Human Abdominal Aortic Aneurysm Tissue
  65. Conflicting Evidence For The Role Of JNK As A Target In Breast Cancer Cell Proliferation: Comparisons Between Pharmacological Inhibition And Selective Shrna …
  66. Cordyceps Militaris Extract Inhibits The Nf-Κb Pathway And Induces Apoptosis Through Mkk7-JNK Signaling Activation In Tk-10 Human Renal Cell Carcinoma
  67. Cox‐2 Inhibitor Ns‐398 Suppresses Doxorubicin‐Induced P53 Accumulation Through Inhibition Of Ros‐Mediated JNK Activation
  68. Cpg Protects Human Monocytic Cells Against Hiv-Vpr–Induced Apoptosis By Cellular Inhibitor Of Apoptosis-2 Through The Calcium-Activated JNK Pathway In A Tlr9 …
  69. Cross-Inhibition Of JNK By P38 Visualized By Multiplexed Fluorescence Imaging
  70. Curcumin Inhibits Lps-Induced Ccl2 Expression Via JNK Pathway In C6 Rat Astrocytoma Cells
  71. Curcumin, A Potential Inhibitor Of Up-Regulation Of Tnf-Alpha And Il-6 Induced By Palmitate In 3T3-L1 Adipocytes Through Nf-Kappab And JNK Pathway
  72. Cyclic Amp Inhibits JNK Activation By Creb-Mediated Induction Of C-Flipl And Mkp-1, Thereby Antagonizing Uv-Induced Apoptosis
  73. Cyclic Amp-Guanine Exchange Factor Activation Inhibits JNK-Dependent Lipopolysaccharide-Induced Apoptosis In Rat Hepatocytes
  74. Cyclin-Dependent Kinase Inhibitor P1446A Induces Apoptosis In A JNK/P38 Mapk-Dependent Manner In Chronic Lymphocytic Leukemia B-Cells
  75. D2/D3 Receptor Agonist Ropinirole Protects Dopaminergic Cell Line Against Rotenone‐Induced Apoptosis Through Inhibition Of Caspase‐And JNK‐Dependent Pathways
  76. Dab2 Inhibits The Cholesterol-Dependent Activation Of JNK By Tgf-Β
  77. Deprenyl, A Therapeutic Agent For Parkinson’S Disease, Inhibits Arsenic Toxicity Potentiated By Gsh Depletion Via Inhibition Of JNK Activation
  78. Design And Characterization Of A Potent And Selective Dual Atp-And Substrate-Competitive Subnanomolar Bidentate C-Jun N-Terminal Kinase (JNK) Inhibitor
  79. Design And Synthesis Of A Novel, Orally Active, Brain Penetrant, Tri-Substituted Thiophene Based JNK Inhibitor
  80. Determination Of Tissue Levels Of A Neuroprotectant Drug: The Cell Permeable JNK Inhibitor Peptide
  81. Dha Selectively Protects Samp-8-Associated Cognitive Deficits Through Inhibition Of JNK
  82. Diphlorethohydroxycarmalol Suppresses Ultraviolet B-Induced Matrix Metalloproteinases Via Inhibition Of JNK And Erk Signaling In Human Keratinocytes
  83. Discovery Of Cc-930, An Orally Active Anti-Fibrotic JNK Inhibitor
  84. Distinct Contributions Of JNK And P38 To Chromium Cytotoxicity And Inhibition Of Murine Embryonic Stem Cell Differentiation
  85. Divergent JNK Phosphorylation Of Hdac3 In Triple-Negative Breast Cancer Cells Determines Hdac Inhibitor Binding And Selectivity
  86. Dose-Dependent Neuroprotective Effect Of The JNK Inhibitor Brimapitide In 5Xfad Transgenic Mice
  87. Downregulation Of Ras C-Terminal Processing By JNK Inhibition
  88. Edaravone Inhibits JNK-C-Jun Pathway And Restores Anti-Oxidative Defense After Ischemia-Reperfusion Injury In Aged Rats
  89. Effect Of C-Jun Nh2-Terminal Kinase (JNK) Inhibitor Sp600125 On Experimental Silicosis In Mice
  90. Effect Of Donor JNK Signal Transduction Inhibition On Transplant Outcome In Brain Dead Rat Model
  91. Effect Of JNK Inhibitor During Islet Isolation And Transplantation
  92. Effect Of JNK Inhibitor In A Rat Model Of Renal Ischemia-Reperfusion Injury
  93. Effect Of JNK Inhibitor Sp600125 On Hair Cell Regeneration In Zebrafish (Danio Rerio) Larvae
  94. Effects Of JNK Inhibitor On Inflammation And Fibrosis In The Ovary Tissue Of A Rat Model Of Polycystic Ovary Syndrome
  95. Effects Of JNK Inhibitor On Puromycin Aminonucleoside-Induced Nephropathy In Rats
  96. Effects Of The JNK Inhibitor Anthra[1,9-Cd]Pyrazol-6(2H)-One (Sp-600125) On Soluble Guanylyl Cyclase Α1 Gene Regulation And Cgmp Synthesis
  97. Effects Of Uva On Tnf‐Α, Il‐1Β, And Il‐10 Expression Levels In Human Keratinocytes And Intervention Studies With An Antioxidant And A JNK Inhibitor
  98. Eliminating Acute Myeloid Leukemia Stem Cells By Targetingthe Niche Microenviromnent: Co-Inhibition Of Tnf/Il1-JNK And Nf-Κb
  99. Encephalopathy And Mechanisms Of Their Development
  100. Er Stress And Ask1-JNK Activation Contribute To Oridonin-Induced Apoptosis And Growth Inhibition In Cultured Human Hepatoblastoma Huh-6 Cells
  101. Erythromycin Restores Corticosteroid Sensitivity Induced By Cse Through Inhibition Of JNK/C-Jun Pathway
  102. Erythromycin Reverses Cigarette Smoke Extract-Induced Corticosteroid Insensitivity By Inhibition Of The JNK/C-Jun Pathway
  103. Estradiol Protects The Cochlea Against Gentamicin Ototoxicity Through Inhibition Of The JNK Pathway
  104. Estrogen Inhibits Starvation‐Induced Apoptosis In Osteocytes By A Redox‐Independent Process Involving Association Of JNK And Glutathione S‐Transferase P1‐1
  105. Evaluation Of Insl3 In Diabetic Testicular Tissue By Admministered JNK Inhibition
  106. Evpp Inhibits Neutrophils Recruitment Via JNK-Caspy Inflammasome Signaling In Vivo
  107. Excitotoxicity‐Induced Endocytosis Mediates Neuroprotection By Tat‐Peptide‐Linked JNK Inhibitor
  108. Exposure To The JNK Inhibitor Sp600125 (Anthrapyrazolone) During Early Zebrafish Development Results In Morphological Defects
  109. Fluid Shear Stress Inhibits Tnf-Α Activation Of JNK But Not Erk1/2 Or P38 In Human Umbilical Vein Endothelial Cells: Inhibitory Crosstalk Among Mapk Family Members
  110. From In-Silico Screening To Anti-Cancer Activity: The Discovery Of A Potent Inhibitor Targeting The JNK-Jip Interaction
  111. Functional P38 Mapk Identified By Biomarker Profiling Of Pancreatic Cancer Restrains Growth Through JNK Inhibition And Correlates With Improved Survival
  112. Gadd45A And Gadd45B Protect Hematopoietic Cells From Uv-Induced Apoptosis Via Distinct Signaling Pathways, Including P38 Activation And JNK Inhibition
  113. G‐Csf‐Mediated Inhibition Of JNK Is A Key Mechanism For Lactobacillus Rhamnosus‐Induced Suppression Of Tnf Production In Macrophages
  114. Genetic And Pharmacological Inhibition Of JNK Ameliorates Hypoxia-Induced Retinopathy Through Interference With Vegf Expression
  115. Ginkgo Biloba Extract Individually Inhibits JNK Activation And Induces C-Jun Degradation In Human Chondrocytes: Potential Therapeutics For Osteoarthritis
  116. Ginsenoside Compound K Protects Human Umbilical Vein Endothelial Cells Against Oxidized Low-Density Lipoprotein-Induced Injury Via Inhibition Of Nuclear …
  117. Ginsenoside Rg1, A Potential JNK Inhibitor, Protects Against Ischemia/Reperfusion-Induced Liver Damage
  118. Gi-Protein-Dependent Inhibition Of Il-12 Production Is Mediated By Activation Of The Phosphatidylinositol 3-Kinase-Protein 3 Kinase B/Akt Pathway And JNK
  119. Glucocorticoid Receptor–JNK Interaction Mediates Inhibition Of The JNK Pathway By Glucocorticoids
  120. Glutaredoxin 1 Overexpression Inhibits JNK Activity And Ameliorates Myocyte Apoptosis And Progression To Heart Failure In Galphaq Overexpressing Transgenic Mice
  121. Glycyrrhetinic Acid Inhibits Icam-1 Expression Via Blocking JNK And Nf-Κb Pathways In Tnf-Α-Activated Endothelial Cells
  122. Gαi3-Dependent Inhibition Of JNK Activity On Intracellular Membranes
  123. Hdac Inhibitor, Scriptaid, Induces Glioma Cell Apoptosis Through JNK Activation And Inhibits Telomerase Activity
  124. Histone Deacetylase Inhibitor Lmk-235-Mediated Ho-1 Expression Induces Apoptosis In Multiple Myeloma Cells Via The JNK/Ap-1 Signaling Pathway
  125. Hiv-1 Nef Inhibits Lipopolysaccharide-Induced Il-12P40 Expression By Inhibiting JNK-Activated Nfκb In Human Monocytic Cells
  126. Hsp90 Inhibitor Snx-2112 Enhances Trail-Induced Apoptosis Of Human Cervical Cancer Cells Via The Ros-Mediated JNK-P53-Autophagy-Dr5 Pathway
  127. Human Jik, A Novel Member Of The Ste20 Kinase Family That Inhibits JNK And Is Negatively Regulated By Epidermal Growth Factor
  128. Identification Of A New JNK Inhibitor Targeting The JNK-Jip Interaction Site
  129. Identification Of An Adamantyl Azaquinolone JNK Selective Inhibitor
  130. Identification Of The Critical Features Of A Small Peptide Inhibitor Of JNK Activity
  131. Impact Of JNK Inhibitor Xg-102 In A Diet-Induced Rat Model Of Non-Alcoholic Steatohepatitis
  132. In Vitro Metabolism Of A Novel JNK Inhibitor Tanzisertib: Interspecies Differences In Oxido-Reduction And Characterization Of Enzymes Involved In Metabolism
  133. Induction Of Apoptosis And Cell Cycle Arrest By A Specific C-Jun Nh2-Terminal Kinase (JNK) Inhibitor, Sp-600125, In Gastrointestinal Cancers
  134. Induction Of Endoreduplication By A JNK Inhibitor Sp600125 In Human Lung Carcinoma A 549 Cells
  135. Influence Of Intense Pulsed Light On The Secretion Of Tgf-Beta1 In Cultured Human Fibroblasts And Intervention Of JNK Inhibitor.
  136. Inhibition Of Astrocyte Fak–JNK Signaling Promotes Subventricular Zone Neurogenesis Through Cntf
  137. Inhibition Of Basal Activity Of C-Jun-Nh2-Terminal Kinase (JNK) Represses The Expression Of Presenilin-1 By A P53-Dependent Mechanism
  138. Inhibition Of Basal P38 Or JNK Activity Enhances Epithelial Barrier Function Through Differential Modulation Of Claudin Expression
  139. Inhibition Of Casein Kinase 2 Protects Oligodendrocytes From Excitotoxicity By Attenuating JNK/P53 Signaling Cascade
  140. Inhibition Of Cell Proliferation And Cell Cycle Progression By Specific Inhibition Of Basal JNK Activity Evidence That Mitotic Bcl-2 Phosphorylation Is JNK …
  141. Inhibition Of C-Jun N Terminal Kinase (JNK) Improves Functional Beta Cell Mass In Human Islets And Leads To Akt And Glycogen Synthase Kinase-3 (Gsk-3) …
  142. Inhibition Of Cytokine-Mediated JNK Signalling By Purinergic P2Y11 Receptors, A Novel Protective Mechanism In Endothelial Cells
  143. Inhibition Of Endocytosis Exacerbates Tnf-Α-Induced Endothelial Dysfunction Via Enhanced JNK And P38 Activation
  144. Inhibition Of Erk And JNK Decreases Both Osmosensitive Taurine Release And Cell Proliferation In Glioma Cells
  145. Inhibition Of Hepatic Mitochondrial Aldehyde Dehydrogenase By Carbon Tetrachloride Through JNK-Mediated Phosphorylation
  146. Inhibition Of JNK Activation Prolongs Survival After Smoke Inhalation From Fires
  147. Inhibition Of JNK Activation Through Nf-Κb Target Genes
  148. Inhibition Of JNK Aggravates The Recovery Of Rat Hearts After Global Ischemia: The Role Of Mitochondrial JNK
  149. Inhibition Of JNK Along With Activation Of Erk1/2 Mapk Pathways Improve Steatohepatitis Among The Rats
  150. Inhibition Of JNK Ameliorates Depressive-Like Behaviors And Reduces The Activation Of Pro-Inflammatory Cytokines And The Phosphorylation Of Glucocorticoid Receptors …
  151. Inhibition Of JNK And P38 Mapk Phosphorylation By 5-(Acetylamino)-4-Oxo-6-Phenyl-2-Hexenoic Acid Methyl Ester And 4-Phenyl-Butenoic Acid Decreases Substance P …
  152. Inhibition Of JNK And Prothymosin-Alpha Sensitizes Hepatocellular Carcinoma Cells To Cisplatin
  153. Inhibition Of JNK By Compound C66 Prevents Pathological Changes Of The Aorta In Stz‐Induced Diabetes
  154. Inhibition Of JNK By Novel Curcumin Analog C66 Prevents Diabetic Cardiomyopathy With A Preservation Of Cardiac Metallothionein Expression
  155. Inhibition Of JNK By Overexpression Of The JNK Binding Domain Of Jip-1 Prevents Apoptosis In Sympathetic Neurons
  156. Inhibition Of JNK Enhances Tgf-Β1-Activated Smad2 Signaling In Mouse Embryonic Lung
  157. Inhibition Of JNK In Hacat Cells Induced Tight Junction Formation With Decreased Expression Of Cytokeratin 5, Cytokeratin 17 And Desmoglein 3
  158. Inhibition Of JNK In Mice Expressing A Desensitization-Resistant Form Of Cb1 Prevents The Development Of Tolerance To The Analgesic Effects Of Δ9-Thc
  159. Inhibition Of JNK Increases Survival Of Transplanted Dopamine Neurons In Parkinsonian Rats
  160. Inhibition Of JNK Mitochondrial Localization And Signaling Is Protective Against Ischemia/Reperfusion Injury In Rats
  161. Inhibition Of JNK Phosphorylation By A Novel Curcumin Analog Prevents High Glucose–Induced Inflammation And Apoptosis In Cardiomyocytes And The Development Of …
  162. Inhibition Of JNK Phosphorylation Reverses Memory Deficit Induced By Β-Amyloid (1–42) Associated With Decrease Of Apoptotic Factors
  163. Inhibition Of JNK Potentiates Temozolomide-Induced Cytotoxicity In U87Mg Glioblastoma Cells Via Suppression Of Akt Phosphorylation
  164. Inhibition Of JNK Promotes Differentiation Of Epidermal Keratinocytes
  165. Inhibition Of JNK Reduces G2/M Transit Independent Of P53, Leading To Endoreduplication, Decreased Proliferation, And Apoptosis In Breast Cancer Cells
  166. Inhibition Of JNK Sensitizes Hypoxic Colon Cancer Cells To Dna-Damaging Agents
  167. Inhibition Of JNK Signaling In The Asian Malaria Vector Anopheles Stephensi Extends Mosquito Longevity And Improves Resistance To Plasmodium Falciparum …
  168. Inhibition Of JNK Signalling Mediates Pparα‐Dependent Protection Against Intrahepatic Cholestasis By Fenofibrate
  169. Inhibition Of JNK Suppresses Autophagy And Attenuates Insulin Resistance In A Rat Model Of Nonalcoholic Fatty Liver Disease
  170. Inhibition Of JNK2 And JNK3 By JNK Inhibitor Ix Induces Prometaphase Arrest-Dependent Apoptotic Cell Death In Human Jurkat T Cells
  171. Inhibition Of Jun N-Terminal Kinase (JNK) Enhances Glucocorticoid Receptor-Mediated Function In Mouse Hippocampal Ht22 Cells
  172. Inhibition Of Pde4 Attenuates Tnf-Α-Triggered Cell Death Through Suppressing Nf-Κb And JNK Activation In Ht-22 Neuronal Cells
  173. Inhibition Of Phosphorylation Of JNK Suppresses Aβ-Induced Er Stress And Upregulates Prosurvival Mitochondrial Proteins In Rat Hippocampus
  174. Inhibition Of Pi3-Kinase Sensitises Hl60 Human Leukaemia Cells To Both Chemotherapeutic Drug-And Fas-Induced Apoptosis By A JNK Independent Pathway
  175. Inhibition Of Spinal C-Jun-Nh2-Terminal Kinase (JNK) Improves Locomotor Activity Of Spinal Cord Injured Rats
  176. Inhibition Of The C-Jun N-Terminal Kinase (JNK) Signaling Pathway By Curcumin
  177. Inhibition Of The JNK Signaling Pathway Increases Sensitivity Of Hepatocellular Carcinoma Cells To Cisplatin By Down-Regulating Expression Of P-Glycoprotein
  178. Inhibition Of The JNK Signalling Pathway Enhances Proteasome Inhibitor‐Induced Apoptosis Of Kidney Cancer Cells By Suppression Of Bag3 Expression
  179. Inhibition Of The JNK/Ap-1 Pathway Reduces Neuronal Death And Improves Behavioral Outcome After Neonatal Hypoxic–Ischemic Brain Injury
  180. Inhibition Of The JNK/Bim Pathway By Hsp70 Prevents Bax Activation In Uv‐Induced Apoptosis
  181. Inhibitor Of Nicotinamide Phosphoribosyltransferase Sensitizes Glioblastoma Cells To Temozolomide Via Activating Ros/JNK Signaling Pathway
  182. Intraperitoneal Injection Of JNK-Specific Inhibitor Sp600125 Inhibits The Expression Of Presenilin-1 And Notch Signaling In Mouse Brain Without Induction Of Apoptosis
  183. Investigating Tnf Inhibition Of Igf-1 Signalling Via JNK In Cell Culture Models Of Skeletal Muscle Atrophy
  184. Investigation Of Hdac Inhibition On Bovine Mammary Cell Inflammation Via Phosphate-Dependent Regulation Of JNK Signaling
  185. Isoliquiritigenin Inhibits JNK/Ap-1 Signaling In Du145 Human Prostate Cancer Cells
  186. Isoliquiritigenin Inhibits Migration And Invasion Of Prostate Cancer Cells: Possible Mediation By Decreased JNK/Ap-1 Signaling
  187. JNK Inactivation Suppresses Osteogenic Differentiation, But Robustly Induces Osteopontin Expression In Osteoblasts Through The Induction Of Inhibitor Of Dna Binding 4 …
  188. JNK Inhibition And Inflammation After Cerebral Ischemia
  189. JNK Inhibition Arrests Cotranslational Degradation
  190. JNK Inhibition As A Potential Strategy In Treating Parkinson’S Disease.
  191. JNK Inhibition Blocks Piperlongumine-Induced Cell Death And Transcriptional Activation Of Heme Oxygenase-1 In Pancreatic Cancer Cells
  192. JNK Inhibition By Glucocorticoids Prevents The Maturation Of Dendritic Cells Induced By Toll-Like Receptor 7 And Toll-Like Receptor 8
  193. JNK Inhibition By Sp600125 Attenuates Trans-10, Cis-12 Conjugated Linoleic Acid-Mediated Regulation Of Inflammatory And Lipogenic Gene Expression
  194. JNK Inhibition By Transforming Growth Factor-Β Type I Receptor (Tgf-Β Ri) In T Cells
  195. JNK Inhibition Improves Obesity-Induced Endothelial Dysfunction And Oxidative Stress Mimicking The Beneficial Effects Of Roux-En …
  196. JNK Inhibition Inhibits Lateral Line Neuromast Hair Cell Development
  197. JNK Inhibition Mimics The Beneficial Effect Of Roux-En-Y Gastric Bypass Surgery On Obesity-Induced Endothelial Dysfunction
  198. JNK Inhibition Of Vmat2 Contributes To Rotenone-Induced Oxidative Stress And Dopamine Neuron Death
  199. JNK Inhibition Protects Dopamine Neurons And Provides Behavioral Improvement In A Rat 6-Hydroxydopamine Model Of Parkinson’S Disease
  200. JNK Inhibition Reduced Retinal Ganglion Cell Death After Ischemia/Reperfusion In Vivo And After Hypoxia In Vitro
  201. JNK Inhibition Reduces Apoptosis And Neovascularization In A Murine Model Of Age-Related Macular Degeneration
  202. JNK Inhibition Reduces Lung Remodeling And Pulmonary Fibrotic Systemic Markers
  203. JNK Inhibition Restores Endothelial Function In Type 2 Diabetes Mellitus
  204. JNK Inhibition Sensitises Hepatocellular Carcinoma Cells But Not Normal Hepatocytes To The Tnf-Related Apoptosis-Inducing Ligand
  205. JNK Inhibition Sensitizes Tumor Cells To Radiation-Induced Premature Senescence Via Bcl-2/Ros/Ddr Signaling Pathway
  206. JNK Inhibitor Alleviates Apoptosis Of Fetal Neural Stem Cells Induced By Emulsified Isoflurane
  207. JNK Inhibitor Cc-930 Reduces Fibrosis In A Murine Model Of Nf1-Deficient Fracture Repair
  208. JNK Inhibitor D-JNKi Promotes Myelination In A Rat Model Of Diffuse White Matter Injury
  209. JNK Inhibitor Protects Dopaminergic Neurons By Reducing Cox-2 Expression In The Mptp Mouse Model Of Subacute Parkinson’S Disease
  210. JNK Inhibitor Sp600125 Attenuates Paraquat-Induced Acute Lung Injury: An In Vivo And In Vitro Study
  211. JNK Inhibitor Sp600125 Attenuates Trans-10, Cis-12 (10, 12) Conjugated Linoleic Acid (Cla)-Mediated Inflammation And Suppression Of Adipogenic And Lipogenic …
  212. JNK Inhibitor Sp600125 Decreased Lipid Peroxidation In Isolated Hepatocytes
  213. JNK Inhibitor Sp600125 Enhances Tgf‑Β‑Induced Apoptosis Of Rbe Human Cholangiocarcinoma Cells In A Smad‑Dependent Manner
  214. JNK Inhibitor Sp600125 Is A Partial Agonist Of Human Aryl Hydrocarbon Receptor And Induces Cyp1A1 And Cyp1A2 Genes In Primary Human Hepatocytes
  215. JNK Inhibitor Sp600125 Promotes The Formation Of Polymerized Tubulin, Leading To G2/M Phase Arrest, Endoreduplication, And Delayed Apoptosis
  216. JNK Inhibitor Sp600125 Protects Against Lipopolysaccharide‑Induced Acute Lung Injury Via Upregulation Of Claudin‑4
  217. JNK Inhibitor Sp600125 Reduces Cox-2 Expression By Attenuating Mrna In Activated Murine J774 Macrophages
  218. JNK Is Constitutively Active In Mantle Cell Lymphoma: Cell Cycle Deregulation And Polyploidy By JNK Inhibitor Sp600125
  219. JNK Pathway Inhibition Enhances Chemotherapeutic Sensitivity To Adriamycin In Nasopharyngeal Carcinoma Cells
  220. JNK Pathway Inhibition Selectively Primes Pancreatic Cancer Stem Cells To Trail-Induced Apoptosis Without Affecting The Physiology Of Normal Tissue Resident …
  221. JNK-In-8, A C-Jun N-Terminal Kinase Inhibitor, Improves Functional Recovery Through Suppressing Neuroinflammation In Ischemic Stroke
  222. JNK‐In‐8, Ac‐Jun N‐Terminal Kinase Inhibitor, Improves Functional Recovery Through Suppressing Neuroinflammation In Ischemic Stroke
  223. Joint Inhibition Of Tor And JNK Pathways Interacts To Extend The Lifespan Of Brachionus Manjavacas (Rotifera)
  224. Late Breaking Abstract-Evaluation Of The JNK Inhibitor, Cc-90001, In A Phase 1B Pulmonary Fibrosis Trial
  225. Leflunomide Or A77 1726 Protect From Acetaminophen-Induced Cell Injury Through Inhibition Of JNK-Mediated Mitochondrial Permeability Transition In Immortalized …
  226. Leishmania Mexicana Promastigotes Down Regulate JNK And P-38 Mapk Activation: Role In The Inhibition Of Camptothecin-Induced Apoptosis Of Monocyte-Derived …
  227. Leukotriene B4 Receptor Inhibitor Ly293111 Induces Cell Cycle Arrest And Apoptosis In Human Anaplastic Large-Cell Lymphoma Cells Via JNK Phosphorylation
  228. Lipoteichoic Acid Upregulates Plasminogen Activator Inhibitor-1 Expression In Human Pleural Mesothelial Cells Via Tlr2/JNK/Ap-1 Pathway
  229. Local Inhibition Of Prc2 Activity By H3. 3K27M Drives Dna Replication Defects Through Misregulation Of The JNK Pathway
  230. Low-Power Laser Irradiation Inhibits Apoptosis Induced By Abeta Via Preventing Ask-1/JNK Pathway
  231. Lycium Barbarum (Wolfberry) Reduces Secondary Degeneration And Oxidative Stress, And Inhibits JNK Pathway In Retina After Partial Optic Nerve Transection
  232. Map Kinase Phosphatase 1 (Mkp-1/Dusp1) Is Neuroprotective In Huntington’S Disease Via Additive Effects Of JNK And P38 Inhibition
  233. Mapk Inhibitors, Particularly The JNK Inhibitor, Increase Cell Death Effects In H2O2-Treated Lung Cancer Cells Via Increased Superoxide Anion And Glutathione …
  234. Mcl-1 Degradation Mediated By JNK Activation Via Mekk1/Tak1-Mkk4 Contributes To Anticancer Activity Of New Tubulin Inhibitor Mt189
  235. Mechanistic Studies Of The Dual Akt And JNK Inhibitor Chaetoglobosin K: Effect On Downstream Pathways And Ap-1 Proteins In Tumorigenic Cells
  236. Metabolism And Disposition Of A Potent And Selective JNK Inhibitor [14C]Tanzisertib Following Oral Administration To Rats, Dogs And Humans
  237. Metformin Protects Against Intestinal Barrier Dysfunction Via Ampkα1‐Dependent Inhibition Of JNK Signalling Activation
  238. Metformin Protects H9C2 Cardiomyocytes From High-Glucose And Hypoxia/Reoxygenation Injury Via Inhibition Of Reactive Oxygen Species Generation And Inflammatory …
  239. Mitochondrial Protection By The JNK Inhibitor Leflunomide Rescues Mice From Acetaminophen‐Induced Liver Injury
  240. Mkp2 Inhibits Tgf-Β1-Induced Epithelial-To-Mesenchymal Transition In Renal Tubular Epithelial Cells Through A JNK-Dependent Pathway
  241. Mkp2 Suppresses Tgf-Β1-Induced Epithelial-To-Mesenchymal Transition Through JNK Inhibition
  242. Modulation Of Amyloid-Β Peptide-Induced Toxicity Through Inhibition Of JNK Nuclear Localization And Caspase-2 Activation
  243. Mtorc1 But Not JNK Inhibition Augments Glucocorticosteroid Efficacy In Multiple Sclerosis (S55. 004)
  244. Murf1 Inhibits JNK Signaling In Cardiac Ischemia Reperfusion Injury By Degrading Phosphorylated Cjun
  245. Myc Inhibits JNK-Mediated Cell Death In Vivo
  246. Neuroprotection Against Ischemic Brain Injury By A Small Peptide Inhibitor Of C-Jun N-Terminal Kinase (JNK) Via Nuclear And Non-Nuclear Pathways
  247. New Microtubulin Inhibitor Mt189 Suppresses Angiogenesis Via The JNK-Vegf/Vegfr2 Signaling Axis
  248. Nicotinamide Mononucleotide Inhibits JNK Activation To Reverse Alzheimer Disease
  249. Nmt1 Inhibition Modulates Breast Cancer Progression Through Stress-Triggered JNK Pathway
  250. Nuclear Hormone Receptor Antagonism With Ap-1 By Inhibition Of The JNK Pathway
  251. Oxidative Stress Resistance Through Blocking Hsp60 Translocation Followed By Sapk/JNK Inhibition In Aged Human Diploid Fibroblasts
  252. P38 Mapk Activation, JNK Inhibition, Neoplastic Growth Inhibition, And Increased Gap Junction Communication In Human Lung Carcinoma And Ras‐Transformed Cells By …
  253. P38Α Mapk Inhibits JNK Activation And Collaborates With Iκb Kinase 2 To Prevent Endotoxin‐Induced Liver Failure
  254. P38Α Mapk Inhibits Stretch-Induced JNK Activation In Cardiac Myocytes Through Mkp-1
  255. Paeoniflorin Inhibits Tributyltin Chloride-Induced Apoptosis In Hypothalamic Neurons Via Inhibition Of Mkk4-JNK Signaling Pathway
  256. Pd08-03: Inhibition Of Mek/Erk-And JNK-Dependent Expression Of Interleukin-6 And Interleukin-8 Targets Basal-Like Breast Cancer Stem Cells.
  257. Pharmacological C-Jun Nh2-Terminal Kinase (JNK) Pathway Inhibition Reduces Severity Of Spinal Muscular Atrophy Disease In Mice.
  258. Pi3K P110Β Isoform Synergizes With JNK In The Regulation Of Glioblastoma Cell Proliferation And Migration Through Akt And Fak Inhibition
  259. Pinch-1 Promotes Bcl-2-Dependent Survival Signalling And Inhibits JNK-Mediated Apoptosis In The Primitive Endoderm
  260. Plasminogen Activator Inhibitor-1 Potentiates Lps-Induced Neutrophil Activation Through A JNK–Mediated Pathway
  261. Posttranslational Modification Of Vesicular Stomatitis Virus Glycoprotein, But Not JNK Inhibition, Is The Antiviral Mechanism Of Sp600125
  262. Potentiation Of Oxaliplatin In Colon Cancer By JNK Inhibition
  263. Primary Resistance To Egfr Inhibition In Glioblastoma Is Mediated By A Tnf-JNK-Axl-Erk Signaling Axis
  264. Prolactin Protects Against Cytokine-Induced Beta-Cell Death By Nfκb And JNK Inhibition
  265. Proteasome Inhibitor Ps‐341 Induces Growth Arrest And Apoptosis Of Non‐Small Cell Lung Cancer Cells Via The JNK/C‐Jun/Ap‐1 Signaling
  266. Proteasome Inhibitors Potentiate Leukemic Cell Apoptosis Induced By The Cyclin-Dependent Kinase Inhibitor Flavopiridol Through A Sapk/JNK– And Nf-Κb …
  267. Protection From Diclofenac-Induced Small Intestinal Injury By The JNK Inhibitor Sp600125 In A Mouse Model Of Nsaid-Associated Enteropathy
  268. Protective Effect Of A JNK Inhibitor Against Retinal Ganglion Cell Loss Induced By Acute Moderate Ocular Hypertension
  269. Protective Effects Of JNK Inhibition In Retinal Ganglion Cells And In Retinal Ischemia/Reperfusion Injury
  270. Protective Effects Of JNK Inhibitor On Cultured Adult Rat Retinal Ganglion Cells
  271. Protective Role Of JNK Inhibitor Sp600125 In Sepsis-Induced Acute Lung Injury
  272. Protective Role Of Taurine Against Arsenic-Induced Mitochondria-Dependent Hepatic Apoptosis Via The Inhibition Of Pkcδ-JNK Pathway
  273. Proteinase-Activated Receptor-2 Mediated Inhibition Of Tnfα-Stimulated JNK Activation—A Novel Paradigm For Gq/11 Linked Gpcrs
  274. Quantitative Proteomic Analysis Reveals Maturation As A Mechanism Underlying Glucocorticoid Resistance In B Lineage All And Re‐Sensitization By JNK Inhibition
  275. Rapamycin Potentiates Dexamethasone-Induced Apoptosis And Inhibits JNK Activity In Lymphoblastoid Cells
  276. Recovery Of Articular Cartilage Metabolism Following Thermal Stress Is Facilitated By Igf-1 And JNK Inhibitor
  277. Reduction Of Autophagy Markers Mediated Protective Effects Of JNK Inhibitor And Bucladesine On Memory Deficit Induced By Aβ In Rats
  278. Regulation Of Gene Expression By The Amyloid Precursor Protein: Inhibition Of The JNK/C-Jun Pathway
  279. Regulation Of Lipopolysaccharide-Induced Lung Inflammation By Plasminogen Activator Inhibitor-1 Through A JNK-Mediated Pathway
  280. Regulation Of Trehalase Expression Inhibits Apoptosis In Diapause Cardioprotective 3′, 4′-Dihydroxyflavonol Attenuation Of JNK And P38Mapk Signalling Involves …
  281. Rescuing Melanoma Epitope-Specific Cytolytic T Lymphocytes From Activation-Induced Cell Death, By Sp600125, An Inhibitor Of JNK: Implications In Cancer …
  282. Resveratrol Confers Cardioprotection Against Ischemia/Reperfusion Injury By Inhibition Of JNK Via Ampk
  283. Role Of JNK Translocation To Mitochondria Leading To Inhibition Of Mitochondria Bioenergetics In Acetaminophen-Induced Liver Injury
  284. Role Of JNK/Atf-2 Pathway In Inhibition Of Thrombospondin-1 (Tsp-1) Expression And Apoptosis Mediated By Doxorubicin And Camptothecin In Ftc-133 Cells
  285. Ros-Dependent Activation Of JNK Converts P53 Into An Efficient Inhibitor Of Oncogenes Leading To Robust Apoptosis
  286. Rosiglitazone Reduces Tau Phosphorylation Via JNK Inhibition In The Hippocampus Of Rats With Type 2 Diabetes And Tau Transfected Sh-Sy5Y Cells
  287. Rubus Coreanus Inhibits Oxidized-Ldl Uptake By Macrophages Through Regulation Of JNK Activation
  288. Sb203580, A Pharmacological Inhibitor Of P38 Map Kinase Transduction Pathway Activates Erk And JNK Map Kinases In Primary Cultures Of Human Hepatocytes
  289. Selective Inhibition Of JNK With A Peptide Inhibitor Attenuates Pain Hypersensitivity And Tumor Growth In A Mouse Skin Cancer Pain Model
  290. Selective Inhibition Of Mitochondrial JNK Signaling Achieved Using Peptide Mimicry Of The Sab Kinase Interacting Motif-1 (Kim1)
  291. Selenite Inhibits The C-Jun N-Terminal Kinase/Stress-Activated Protein Kinase (JNK/Sapk) Through A Thiol Redox Mechanism
  292. Sesquiterpene Dimer (Dsf-52) From Artemisia Argyi Inhibits Microglia-Mediated Neuroinflammation Via Suppression Of Nf-Κb, JNK/P38 Mapks And Jak2/Stat3 …
  293. Shear Stress Inhibition Of H2O2 Induced P66Shc Phosphorylation By Ask1–JNK Inactivation In Endothelium
  294. Silencing Glycogen Synthase Kinase-3Β Inhibits Acetaminophen Hepatotoxicity And Attenuates JNK Activation And Loss Of Glutamate Cysteine Ligase And Myeloid Cell …
  295. Silencing Sox2 Expression By Rna Interference Inhibits Proliferation, Invasion And Metastasis, And Induces Apoptosis Through Map4K4/JNK Signaling Pathway In …
  296. Sirtuin 3 Inhibition Induces Mitochondrial Stress In Tongue Cancer By Targeting Mitochondrial Fission And The JNK-Fis1 Biological Axis
  297. Smad4 Inhibits Cell Migration Via Suppression Of JNK Activity In Human Pancreatic Carcinoma Panc‑1 Cells
  298. Small Peptide Inhibitor Of JNKs Protects Against Mptp-Induced Nigral Dopaminergic Injury Via Inhibiting The JNK-Signaling Pathway
  299. Snp-Induced Apoptosis May Be Mediated With Caspase Inhibitor By JNK Signaling Pathways In Rabbit Articular Chondrocytes
  300. Sorafenib Suppresses JNK-Dependent Apoptosis Through Inhibition Of Zak
  301. Sp600125 Suppresses Cdk1 And Induces Endoreplication Directly From G2 Phase, Independent Of JNK Inhibition
  302. Sp600125, A Competitive Inhibitor Of JNK Attenuates Streptozotocin Induced Neurocognitive Deficit And Oxidative Stress In Rats
  303. Sp600125, A JNK Inhibitor, Suppresses Growth Of JNK-Inactive Glioblastoma Cells Through Cell-Cycle G2/M Phase Arrest
  304. Sp600125, A New JNK Inhibitor, Protects Dopaminergic Neurons In The Mptp Model Of Parkinson’S Disease
  305. Sp600125, A Selective JNK Inhibitor, Aggravates Hepatic Ischemia-Reperfusion Injury
  306. Sp600125, A Selective JNK Inhibitor, Protects Ischemic Renal Injury Via Suppressing The Extrinsic Pathways Of Apoptosis
  307. Specific Inhibition Of The JNK Pathway Promotes Locomotor Recovery And Neuroprotection After Mouse Spinal Cord Injury
  308. Specific JNK Inhibition By D-JNKi1 Protects Purkinje Cells From Cell Death In Lurcher Mutant Mouse
  309. Stimulation Of Insulin Signaling And Inhibition Of JNK-Ap1 Activation Protect Cells From Amyloid-Β-Induced Signaling Dysregulation And Inflammatory Response
  310. Stressor-Like Effects Of C-Jun N-Terminal Kinase (JNK) Inhibition
  311. Structural And Biological Evaluation Of Halogen Derivatives Of 1, 9-Pyrazoloanthrones Towards The Design Of A Specific Potent Inhibitor Of C-Jun-N-Terminal Kinase (JNK)
  312. Subconjunctival Injection Of Xg-102, A JNK Inhibitor Peptide, In Patients With Intraocular Inflammation: A Safety And Tolerability Study
  313. Sulfatase 2 Protects Hepatocellular Carcinoma Cells Against Apoptosis Induced By The Pi3K Inhibitor Ly294002 And Erk And JNK Kinase Inhibitors
  314. Suppression Of Hiv-1 Viral Replication And Cellular Pathogenesis By A Novel P38/JNK Kinase Inhibitor
  315. Suppression Of Stress Kinase JNK Is Involved In Hsp72-Mediated Protection Of Myogenic Cells From Transient Energy Deprivation Hsp72 Alleviates The Stress-Induced …
  316. Synergistic Effect Of Pi3Kδ Inhibitor Cal-101 And JNK Inhibitor Sp600125 On Glioblastoma Cell Proliferation
  317. Synergistic Inhibition Of Erk1/2 And JNK, Not P38, Phosphorylation Ameliorates Neuronal Damages After Traumatic Brain Injury
  318. Targeted Inhibition Of The Dual Specificity Phosphatases Dusp1 And Dusp6 Suppress Mpnst Growth Via JNK
  319. Targeting Ciks Expression Or Ciks/Il-17Ra Interaction Inhibits Il-17A-Induced Cardiomyocyte Death By Reversing JNK Activation And Dusp1/Mkp-1 Inhibition
  320. Targeting Muc 1 And JNK By Rna Interference And Inhibitor Inhibit The Development Of Hepatocellular Carcinoma
  321. Targeting The JNK Mapk Cascade For Inhibition: Basic Science And Therapeutic Potential
  322. Taz Inhibition Promotes Il-2-Induced Apoptosis Of Hepatocellular Carcinoma Cells By Activating The JNK/F-Actin/Mitochondrial Fission Pathway
  323. The Bradykinin-Cgmp-Pkg Pathway Augments Insulin Sensitivity Via Upregulation Of Mapk Phosphatase-5 And Inhibition Of JNK
  324. The C‐Jun N‐Terminal Kinase (JNK) Inhibitor Xg‐102 Enhances The Neuroprotection Of Hyperbaric Oxygen After Cerebral Ischaemia In Adult Rats
  325. The Combination Of Silencing Bag3 And Inhibition Of The JNK Pathway Enhances Hyperthermia Sensitivity In Human Oral Squamous Cell Carcinoma Cells
  326. The Covalent JNK Inhibitor, JNK-In-8, Synergizes With Lapatinib To Cause Cell Death In Basal-Like Breast Cancer Cell Lines
  327. The Critical Features And The Mechanism Of Inhibition Of A Kinase Interaction Motif-Based Peptide Inhibitor Of JNK
  328. The Effect Of The JNK Inhibitor, Jip Peptide, On Human T Lymphocyte Proliferation And Cytokine Production
  329. The Effects Of Short-Term JNK Inhibition On The Survival And Growth Of Aged Sympathetic Neurons
  330. The Ephb6 Receptor Inhibits JNK Activation In T Lymphocytes And Modulates T Cell Receptor-Mediated Responses
  331. The Impact Of JNK Inhibitor D-JNKi-1 In A Murine Model Of Chronic Colitis Induced By Dextran Sulfate Sodium
  332. The Influence Of JNK And P38 Mapk Inhibition On Il-12P40 And Il-23 Production Depending On Il12B Promoter Polymorphism
  333. The Influence Of JNK Inhibitor On Hemodynamics After Ischemia/Reperfusion Injury To The Heart In Rats
  334. The JNK Binding Domain Of Islet-Brain 1 Inhibits Il-1 Induced JNK Activity And Apoptosis But Not The Transcription Of Key Proapoptotic Or Protective Genes In Insulin …
  335. The JNK Inhibitor D-JNKi-1 Blocks Apoptotic JNK Signaling In Brain Mitochondria
  336. The JNK Inhibitor Sp600125 Enhances Dihydroartemisinin‐Induced Apoptosis By Accelerating Bax Translocation Into Mitochondria In Human Lung Adenocarcinoma …
  337. The JNK Inhibitor Sp600129 Enhances Apoptosis Of Hcc Cells Induced By The Tumor Suppressor Wwox
  338. The JNK Inhibitor Xg-102 Protects Against Tnbs-Induced Colitis
  339. The JNK Inhibitor Xg-102 Protects From Ischemic Damage With Delayed Intravenous Administration Also In The Presence Of Recombinant Tissue Plasminogen Activator
  340. The Mkk7 Inhibitor Peptide Gadd45Β-I Attenuates Er Stress-Induced Mitochondrial Dysfunction In Ht22 Cells: Involvement Of JNK-Wnt Pathway
  341. The N-Cor-Hdac3 Nuclear Receptor Corepressor Complex Inhibits The JNK Pathway Through The Integral Subunit Gps2
  342. The Nedd8-Activating Enzyme Inhibitor, Mln4924, Cooperates With Trail To Augment Apoptosis Through JNK-Dependent Downregulation Of C-Flip In Head And Neck …
  343. The Neuroprotective Actions Of Fk506 Binding Protein Ligands: Neuronal Survival Is Triggered By De Novo Rna Synthesis, But Is Independent Of Inhibition Of JNK And …
  344. The Novel Akt Inhibitor, Perifosine, Induces Caspase-Dependent Apoptosis And Downregulates P-Glycoprotein Expression In Multidrug-Resistant Human T-Acute …
  345. The Novel JNK Inhibitor As602801 Inhibits Cancer Stem Cells In Vitro And In Vivo
  346. The Proteasome Inhibitor Bortezomib Enhances Atra-Induced Differentiation Of Neuroblastoma Cells Via The JNK Mitogen-Activated Protein Kinase Pathway
  347. The Protectiveeffects Of JNK Inhibitor On Β-Amyloid-Induced Neuronal Apoptotic Factors And Spatial Memory Behavior, Using …
  348. The Protein Kinase C Inhibitor, Ro-31-7459, Is A Potent Activator Of Erk And JNK Map Kinases In Huvecs And Yet Inhibits Cyclic Amp-Stimulated Socs-3 …
  349. The Reverse-Mode Ncx1 Activity Inhibitor Kb-R7943 Promotes Prostate Cancer Cell Death By Activating The JNK Pathway And Blocking Autophagic Flux
  350. The Sequential Combination Of A JNK Inhibitor And Simvastatin Protects Porcine Islets From Peritransplant Apoptosis And Inflammation
  351. The Specific JNK Inhibitor Sp600125 Targets Tumour Necrosis Factor‐Α Production And Epithelial Cell Apoptosis In Acute Murine Colitis
  352. The Specific, Reversible JNK Inhibitor Sp600125 Improves Survivability And Attenuates Neuronal Cell Death In Experimental Cerebral Malaria (Ecm)
  353. The Synergistic Repressive Effect Of Nf-Κb And JNK Inhibitor On The Clonogenic Capacity Of Jurkat Leukemia Cells
  354. The Tat-JNK Inhibitor Peptide Interferes With Beta Amyloid Protein Stability
  355. Time-Staggered Inhibition Of JNK Effectively Sensitizes Chemoresistant Ovarian Cancer Cells To Cisplatin And Paclitaxel
  356. Tissue Inhibitor Of Metalloproteinase-3 Inhibits Neonatal Mouse Cardiomyocyte Proliferation Via Egfr/JNK/Sp-1 Signaling
  357. Tnfalpha Reduces Glucocorticoid-Dependent Transcription: Rescue By Long-Acting Beta2-Adrenceptor Agonists And JNK Inhibition
  358. Tnf-Α Up-Regulates Cellular Inhibitor Of Apoptosis Protein 2 (C-Iap2) Via C-Jun N-Terminal Kinase (JNK) Pathway In Nasopharyngeal Carcinoma
  359. Trail-Resistance In Pancreatic Cancer Stem Cells Can Be Regulated Through JNK Pathway Inhibition Without Impacting Resident Stem Cell Physiology
  360. Transferred Tumor Suppressor Blu Inhibits Proliferation Of Nasopharyngeal Carcinoma Cells By Regulation Of Cell Cycle, JNK And Cyclin D1 Promoters
  361. Treatment With A JNK Inhibitor Increases, Whereas Treatment With A P38 Inhibitor Decreases, H2O2-Induced Calf Pulmonary Arterial Endothelial Cell Death
  362. Triptolide Inhibits Cox‐2 Expression And Pge2 Release By Suppressing The Activity Of Nf‐Κb And JNK In Lps‐Treated Microglia
  363. Urotensin Ii Inhibitor Eases Neuropathic Pain By Suppressing The JNK/Nf-Κb Pathway
  364. Ursolic Acid Induces Pc‐3 Cell Apoptosis Via Activation Of JNK And Inhibition Of Akt Pathways In Vitro
  365. Use Of Saikosaponin D And JNK Inhibitor Sp600125, Alone Or In Combination, Inhibits Malignant Properties Of Human Osteosarcoma U2 Cells
  366. Yes-Associated Protein Reduces Neuroinflammation Through Upregulation Of Sirt3 And Inhibition Of JNK Signaling Pathway

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