- μ-Opposing actions of the κ–opiod Receptor
- Structure of the human κ–opiod Receptor in complex with JDTic
- The dynorphin/κ–opiod Receptor system and its role in psychiatric disorders
- Development of κ opiod Receptor antagonists
- Dynorphin is a specific endogenous ligand of the κ opiod Receptor
- Molecular cloning and tissue distribution of a putative member of the rat opiod Receptor gene family that is not a μ, δ or κ opiod Receptor type
- Molecular cloning of a rat κ opiod Receptor reveals sequence similarities to the μ and δ opiod Receptors
- Quantitative autoradiographic mapping of μ-, δ-and κ–opiod Receptors in knockout mice lacking the μ-opiod Receptor gene
- κ–opiod Receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction
- Molecular cloning and expression of a rat κ opiod Receptor
- Cloning of a human κ opiod Receptor from the brain
- Pharmacological properties of JDTic: A novel κ–opiod Receptor antagonist
- κ opiod Receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses
- μ-and κ–opiod Receptor-meiated opiod effects on social play in juvenile rats
- Antipruritic activity of the κ–opiod Receptor agonist, TRK-820
- Effects of κ–opiod Receptor ligands on intracranial self-stimulation in rats
- CI‐977, a novel and selective agonist for the κ‐opiod Receptor
- Depressive-like effects of the κ–opiod Receptor agonist salvinorin A on behavior and neurochemistry in rats
- Cellular mechanism for anti-analgesic action of agonists of the κ–opiod Receptor
- GEC1 interacts with the κ opiod Receptor and enhances expression of the Receptor
- Modulation of the behavioral and neurochemical effects of psychostimulants by κ‐opiod Receptor systems
- The role of κ–opiod Receptor activation in mediating antinociception and addiction
- 5′-Guanidinonaltrindole, a highly selective and potent κ–opiod Receptor antagonist
- The role of the dynorphin/κ opiod Receptor system in anxiety
- Structure and chromosomal mapping of genes for the mouse κ–opiod Receptor and an opiod Receptor homologue (MOR-C)
- Asymmetric synthesis of salvinorin A, a potent κ opiod Receptor agonist
- Formation of μ-/κ–opiod Receptor heterodimer is sex-dependent and mediates female-specific opiod analgesia
- The intrinsic antinociceptive effects of oxycodone appear to be κ–opiod Receptor mediated
- Neuropathic pain activates the endogenous κ opiod system in mouse spinal cord and induces opiod Receptor tolerance
- Isolation of a human κ opiod Receptor cDNA from placenta
- Antidepressant-like effects of κ–opiod Receptor antagonists in the forced swim test in rats
- Research and development of κ opiod Receptor agonists and δ opiod Receptor agonists
- Anxiolytic-like effects of κ–opiod Receptor antagonists in models of unlearned and learned fear in rats
- Discovery of aminobenzyloxyarylamides as κ opiod Receptor selective antagonists: application to preclinical development of a κ opiod Receptor antagonist Receptor …
- Distinct mechanisms for activation of the opiod Receptor-like 1 and κ–opiod Receptors by nociceptin and dynorphin A
- Localization of the κ opiod Receptor in lipid rafts
- Salvinorin A: a novel and highly selective κ–opiod Receptor agonist
- Big dynorphin as a putative endogenous ligand for the κ‐opiod Receptor
- Primary astroglial cultures derived from several rat brain regions differentially express μ, δ and κ opiod Receptor mRNA
- Quantitative autoradiography of μ-, δ-and κ1 opiod Receptors in κ–opiod Receptor knockout mice
- Studies toward the pharmacophore of salvinorin A, a potent κ opiod Receptor agonist
- U50, 488, a κ opiod Receptor agonist, attenuates cocaine-induced increases in extracellular dopamine in the nucleus accumbens of rats
- Long term κ–opiod Receptor blockade following nor-binaltorphimine
- Identification of novel functionally selective κ–opiod Receptor scaffolds
- 2-Methoxymethyl-salvinorin B is a potent κ opiod Receptor agonist with longer lasting action in vivo than salvinorin A
- Systemic κ‐opiod Receptor antagonism by nor‐binaltorphimine reduces dependence‐induced excessive alcohol self‐administration in rats
- Synthesis and κ–opiod Receptor activity of furan-substituted salvinorin A analogues
- Salvinorin A, an active component of the hallucinogenic sage Salvia divinorum is a highly efficacious κ–opiod Receptor agonist: structural and functional …
- Endogenous κ–opiod Receptor systems regulate mesoaccumbal dopamine dynamics and vulnerability to cocaine
- The selective κ–opiod Receptor agonist U50, 488H attenuates voluntary ethanol intake in the rat
- Novel opiod cyclic tetrapeptides: Trp isomers of CJ‐15,208 exhibit distinct opiod Receptor agonism and short‐acting κ opiod Receptor antagonism
- μ-, δ-and κ–opiod Receptor populations are differentially altered in distinct areas of postmortem brains of Alzheimer’s disease patients
- Distribution of κ opiod Receptor mRNA in adult mouse brain: an in situ hybridization histochemistry study
- Antinociceptive and hypothermic effects of salvinorin A are abolished in a novel strain of κ–opiod Receptor-1 knockout mice
- Potent antinociceptive effects of TRK-820, a novel κ–opiod Receptor agonist
- Decreased oral self‐administration of alcohol in κ‐opiod Receptor knock‐out mice
- κ–opiod Receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine
- The effects of spiradoline (U‐62066E), a κ‐opiod Receptor agonist, on neuroendocrine function in man
- Chemotype-selective modes of action of κ–opiod Receptor agonists
- The G protein–biased κ–opiod Receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo
- The expression of δ-and κ–opiod Receptor is enhanced during intestinal inflammation in mice
- Characterization of mechanical withdrawal responses and effects of μ-, δ-and κ–opiod agonists in normal and μ-opiod Receptor knockout mice
- Molecular interaction between butorphanol and κ–opiod Receptor
- κ–opiod Receptor is colocalized in GnRH and KNDy cells in the female ovine and rat brain
- Antidepressant-like effects of κ–opiod Receptor antagonists in Wistar Kyoto rats
- Exploration of the SAR connection between morphinan-and arylacetamide-based κ opiod Receptor (κOR) agonists using the strategy of bridging
- Hallucinatory and rewarding effect of salvinorin A in zebrafish: κ–opiod and CB1-cannabinoid Receptor involvement
- Neuroprotective actions of GR89696, a highly potent and selective κ‐opiod Receptor agonist
- Buprenorphine is a potent κ–opiod Receptor antagonist in pigeons and mice
- Functional interaction among opiod Receptor types: up-regulation of μ-and δ-opiod Receptor functions after repeated stimulation of κ–opiod Receptors
- Analgesia from a peripherally active κ–opiod Receptor agonist in patients with chronic pancreatitis
- Strategies for developing κ opiod Receptor agonists for the treatment of pain with fewer side effects
- Agonist‐induced phosphorylation of the κ‐opiod Receptor
- Sensitization to the behavioral effects of cocaine: modulation by dynorphin and κ–opiod Receptor agonists
- Isolation of a novel cDNA encoding a putative membrane Receptor with high homology to the cloned μ, δ, and κ opiod Receptors
- Sex-related differences in mechanical nociception and antinociception produced by μ-and κ–opiod Receptor agonists in rats
- Bi-directional heterologous desensitization between the major HIV-1 co-Receptor CXCR4 and the κ–opiod Receptor
- Disruption of the κ–opiod Receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ-agonist U-50,488 H …
- Toward a structure-based model of salvinorin A recognition of the κ–opiod Receptor
- Regional, developmental, and cell cycle‐dependent differences in μ, δ, and κ‐opiod Receptor expression among cultured mouse astrocytes
- Synthesis and evaluation of 11C-LY2795050 as a κ–opiod Receptor antagonist radiotracer for PET imaging
- Gz coupling to the rat κ–opiod Receptor
- Noribogaine is a G-protein biased κ–opiod Receptor agonist
- Involvement of the κ–opiod Receptor in the anxiogenic-like effect of CP 55,940 in male rats
- Detection of opiod Receptor mRNA by RT-PCR reveals alternative splicing for the δ-and κ–opiod Receptors
- Autoradiography of [3H] U-69593 binding sites in rat brain: evidence for κ opiod Receptor subtypes
- LPK-26, a novel κ–opiod Receptor agonist with potent antinociceptive effects and low dependence potential
- Hippocampal dynorphin B injections impair spatial learning in rats: a κ–opiod Receptor-mediated effect
- PD117302: a selective agonist for the κ‐opiod Receptor
- Long-acting κ opiod antagonists disrupt Receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase
- Double in situ hybridization study on coexistence of μ-, δ-and κ–opiod Receptor mRNAs with preprotachykinin A mRNA in the rat dorsal root ganglia
- Norbinaltorphimine, a selective κ–opiod Receptor antagonist, induces an itch-associated response in mice
- Enhanced κ–opiod Receptor-mediated analgesia by antisense targeting the σ1 Receptor
- Differential agonist regulation of the human κ‐opiod Receptor
- δ-, but not μ-and κ-, opiod Receptor activation protects neocortical neurons from glutamate-induced excitotoxic injury
- κ–opiod Receptor activation modulates Ca2+ currents and secretion in isolated neuroendocrine nerve terminals
- The μ‐opiod Receptor agonist morphine, but not agonists at δ‐or κ‐opiod Receptors, induces peripheral antinociception mediated by cannabinoid Receptors
- … -based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the κ–opiod Receptor
- Mechanisms of agonist-induced down-regulation of the human κ–opiod Receptor: internalization is required for down-regulation
- Dynorphin peptides differentially regulate the human κ opiod Receptor
- Functional effects of systemically administered agonists and antagonists of μ, δ, and κ opiod Receptor subtypes on body temperature in mice
- Murine chromosomal location of the μ and κ opiod Receptor genes
- Duration of action of a broad range of selective κ–opiod Receptor antagonists is positively correlated with c-Jun N-terminal kinase-1 activation
- Receptor‐selective changes in µ‐, δ‐and κ‐opiod Receptors after chronic naltrexone treatment in mice
- Synthesis of CJ-15,208, a novel κ–opiod Receptor antagonist
- Synthesis and pharmacological evaluation of 5-pyrrolidinylquinoxalines as a novel class of peripherally restricted κ–opiod Receptor agonists
- Chronic muscle pain induced by repeated acid injection is reversed by spinally administered μ-and δ-, but not κ-, opiod Receptor agonists
- κ opiod Receptor ligands regulate angiogenesis in development and in tumours
- Phosphorylation of a carboxyl-terminal serine within the κ–opiod Receptor produces desensitization and internalization
- Association of in vivo κ–opiod Receptor availability and the transdiagnostic dimensional expression of trauma-related psychopathology
- Autoradiographic mapping of the opiod Receptor-like 1 (ORL1) Receptor in the brains of μ-, δ-or κ–opiod Receptor knockout mice
- Transformation of a κ–opiod Receptor Antagonist to a κ-Agonist by Transfer of a Guanidinium Group from the 5 ‘-to 6 ‘-Position of Naltrindole
- Modulation of anxiety-related behaviors by μ-and κ–opiod Receptor agonists depends on the social status of mice
- U50, 488H-induced internalization of the human κ opiod Receptor involves a β-arrestin-and dynamin-dependent mechanism: κ Receptor internalization is not …
- Repeated exposure to the κ–opiod Receptor agonist salvinorin A modulates extracellular signal-regulated kinase and reward sensitivity
- Mechanism of diuretic action of U-62,066 E, a κ opiod Receptor agonist
- Anxiety and ethanol consumption in victorious and defeated mice; effect of κ–opiod Receptor activation
- The atomistic level structure for the activated human κ–opiod Receptor bound to the full Gi protein and the MP1104 agonist
- DAMGO, a μ‐opiod Receptor selective ligand, distinguishes between μ‐and κ‐opiod Receptors at a different region from that for the distinction between μ‐and δ …
- Properties of a κ–opiod Receptor expressed in CHO cells: interaction with multiple G-proteins is not specific for any individual Gα subunit and is similar to that of other …
- Abuse potential and pharmacodynamic characteristics of oral and intranasal eluxadoline, a mixed μ-and κ–opiod Receptor agonist and δ-opiod Receptor antagonist
- Suppression of the GnRH pulse generator by neurokinin B involves a κ–opiod Receptor-dependent mechanism
- Agonist-promoted Lys63-linked polyubiquitination of the human κ–opiod Receptor is involved in Receptor down-regulation
- Suppression of morphine withdrawal by electroacupuncture in rats: dynorphin and κ–opiod Receptor implicated
- Stress-induced activation of the dynorphin/κ–opiod Receptor system in the amygdala potentiates nicotine conditioned place preference
- 6′-Guanidinonaltrindole (6′-GNTI) is a G protein-biased κ–opiod Receptor agonist that inhibits arrestin recruitment
- Pharmacology and anti‐addiction effects of the novel κ opiod Receptor agonist M esyl S al B, a potent and long‐acting analogue of salvinorin A
- Essential structure of the κ opiod Receptor agonist nalfurafine for binding to the κ Receptor
- Pharmacological properties of TRK-820 on cloned μ-, δ-and κ–opiod Receptors and nociceptin Receptor
- Agonist-dependent desensitization of the κ opiod Receptor by G protein Receptor kinase and β-arrestin
- The κ opiod Receptor and food intake
- Identification of short-acting κ–opiod Receptor antagonists with anxiolytic-like activity
- Hypothalamic κ–opiod Receptor modulates the orexigenic effect of ghrelin
- Cardioprotection of preconditioning by metabolic inhibition in the rat ventricular myocyte: involvement of κ–opiod Receptor
- Central nicotine induces browning through hypothalamic κ opiod Receptor
- Central κ–opiod Receptor-mediated antidepressant-like effects of nor-Binaltorphimine: Behavioral and BDNF mRNA expression studies
- Antagonists of the κ‐opiod Receptor enhance allodynia in rats and mice after sciatic nerve ligation
- A regulatory variation in OPRK1, the gene encoding the κ–opiod Receptor, is associated with alcohol dependence
- κ–opiod Receptor-transfected cell lines: modulation of adenylyl cyclase activity following acute and chronic opiod treatments
- κ–opiod Receptor agonist U50, 488H modulates cocaine and morphine self-administration in drug-naive rats and mice
- Hypoxia induces internalization of κ–opiod Receptor
- Immunomodulatory action of class μ, δ-and κ–opiod Receptor agonists in mice
- L-type Ca2+ channel modulation by dihydropyridines potentiates κ–opiod Receptor agonist induced acute analgesia and inhibits development of tolerance in rats
- Immunosuppression by δ-opiod antagonist naltrindole: δ-and triple μ/δ/κ–opiod Receptor knockout mice reveal a nonopiod activity
- Exposure to the selective κ–opiod Receptor agonist salvinorin A modulates the behavioral and molecular effects of cocaine in rats
- Analgesic efficacy of peripheral κ–opiod Receptor agonist CR665 compared to oxycodone in a multi-modal, multi-tissue experimental human pain model: selective …
- Copb1-facilitated axonal transport and translation of κ opiod–Receptor mRNA
- Pulsed magnetic field induced “analgesia” in the land snail, Cepaea nemoralis, and the effects of μ, δ, and κ opiod Receptor agonists/antagonists
- Increased κ–opiod Receptor expression and function during chronic visceral hypersensitivity
- Role of κ–opiod Receptor activation in pharmacological preconditioning of swine
- Antidepressive effects of the κ–opiod Receptor agonist salvinorin A in a rat model of anhedonia
- Region selective up-regulation of μ-, δ-and κ–opiod Receptors but not opiod Receptor-like 1 Receptors in the brains of enkephalin and dynorphin knockout mice
- Stimulation of κ–opiod Receptor reduces isoprenaline-induced cardiac hypertrophy and fibrosis
- Targeting opiod Receptor signaling in depression: do we need selective κ opiod Receptor antagonists?
- κ–opiod Receptor activation in dopamine neurons disrupts behavioral inhibition
- In situ hybridization study of μ-and κ–opiod Receptor mRNAs in the rat spinal cord and dorsal root ganglia
- Chemical coding of neurons expressing δ-and κ–opiod Receptor and type I vanilloid Receptor immunoreactivities in the porcine ileum
- Behavioral stress may increase the rewarding valence of cocaine-associated cues through a dynorphin/κ–opiod Receptor-mediated mechanism without …
- Allosterism within δ opiod–κ opiod Receptor Heteromers in Peripheral Sensory Neurons: Regulation of κ opiod Agonist Efficacy
- κ–opiod Receptor agonist suppression of HIV-1 expression in CD4+ lymphocytes
- Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opiod Receptor agonist
- Receptor occupancy of the κ–opiod antagonist LY2456302 measured with positron emission tomography and the novel radiotracer 11C-LY2795050
- Axonal mRNA transport and localized translational regulation of κ–opiod Receptor in primary neurons of dorsal root ganglia
- Pharmacological activities of optically pure enantiomers of the κ opiod agonist, U50, 488, and its cis diastereomer: evidence for three κ Receptor subtypes
- κ–opiod Receptor stimulation modulates TLR4/NF-κB signaling in the rat heart subjected to ischemia–reperfusion
- Regulation of mouse κ opiod Receptor gene expression by retinoids
- Evidence that nalorphine, butorphanol and oxilorphan are partial agonists at a κ–opiod Receptor
- The macrocyclic tetrapeptide [D‐T rp] CJ‐15,208 produces short‐acting κ opiod Receptor antagonism in the CNS after oral administration
- Effects of peripherally restricted κ opiod Receptor agonists on pain-related stimulation and depression of behavior in rats
- κ opiod Receptor-mediated analgesia in the developing rat
- Antiarrhythmic effect mediated by κ–opiod Receptor is associated with Cx43 stabilization
- Phosphatidylinositol‐3 kinase is distinctively required for µ‐, but not κ‐opiod Receptor‐induced activation of c‐Jun N‐terminal kinase
- κ–opiod Receptor participates of NSAIDs peripheral antinociception
- Selective changes in μ, δ and ϰ opiod Receptor binding in certain limbic regions of the brain in Alzheimer’s disease patients
- Sequence of κ–opiod Receptor cDNA in the R1. 1 thymoma cell line
- Development of novel quinoxaline-based κ–opiod Receptor agonists for the treatment of neuroinflammation
- Prodynorphin, proenkephalin and κ opiod Receptor mRNA responses to acute “binge” cocaine
- Effects of atypical κ–opiod Receptor agonists on intrathecal morphine-induced itch and analgesia in primates
- Repeated stress dysregulates κ–opiod Receptor signaling in the dorsal raphe through a p38α MAPK-dependent mechanism
- Molecular switches of the κ opiod Receptor triggered by 6′-GNTI and 5′-GNTI
- Sodium channel blocking actions of the κ–opiod Receptor agonist U50, 488 contribute to its visceral antinociceptive effects
- Sensitization to the conditioned rewarding effects of morphine and cocaine: differential effects of the κ–opiod Receptor agonist U69593
- An electrophysiological basis for the antiarrhythmic actions of the κ–opiod Receptor agonist U-50,488 H
- In situ hybridization study of κ–opiod Receptor mRNA in the rat brain
- Effects of a newly synthesized κ–opiod Receptor agonist, TRK-820, on the discriminative stimulus and rewarding effects of cocaine in rats
- Corticotropin-releasing factor (CRF)-induced disruption of attention in rats is blocked by the κ–opiod Receptor antagonist JDTic
- Effects of the κ–opiod Receptor agonist U-50,488 on morphine-induced place preference conditioning in the developing rat
- opiod Receptor-mediated suppression of humoral immune response in vivo and in vitro: involvement of κ opiod Receptors
- Lack of cross-tolerance between U69, 593 and bremazocine suggest κ–opiod Receptor multiplicity in mice
- Impact of pharmacological manipulation of the κ–opiod Receptor system on self-grooming and anhedonic-like behaviors in male mice
- Test–retest reproducibility of binding parameters in humans with 11C-LY2795050, an antagonist PET radiotracer for the κ opiod Receptor
- Effects of peripheral κ opiod Receptor activation on inflammatory mechanical hyperalgesia in male and female rats
- μ-, δ-, and κ–opiod Receptor agonists selectively modulate sexual behaviors in the female rat: differential dependence on progesterone
- Structure and expression of a rat κ opiod Receptor gene
- Myocardial apoptosis and infarction after ischemia/reperfusion are attenuated by κ–opiod Receptor agonist
- Investigation of inactive-state κ opiod Receptor homodimerization via single-molecule microscopy using new antagonistic fluorescent probes
- N-Glycosylation of the Human κ opiod Receptor Enhances Its Stability but Slows Its Trafficking along the Biosynthesis Pathway
- Further evidence for the implication of a κ–opiod Receptor mechanism in the production of psychological stress-induced analgesia
- Toosendanin-induced apoptosis in colorectal cancer cells is associated with the κ–opiod Receptor/β-catenin signaling axis
- κ–opiod Receptor expression defines a phenotypically distinct subpopulation of astroglia: relationship to Ca2+ mobilization, development, and the antiproliferative …
- Feeding responses to μ-, δ-and κ–opiod Receptor agonists in the meat-type chick
- κ–opiod Receptor activation promotes mitochondrial fusion and enhances myocardial resistance to ischemia and reperfusion injury via STAT3-OPA1 pathway
- Constraining endomorphin-1 by β, α-hybrid dipeptide/heterocycle scaffolds: identification of a novel κ–opiod Receptor selective partial agonist
- G protein signaling–biased agonism at the κ–opiod Receptor is maintained in striatal neurons
- Dynorphin and κ–opiod Receptor dysregulation in the dopaminergic reward system of human alcoholics
- Identification of the three-dimensional pharmacophore of κ–opiod Receptor agonists
- Antinociceptive and Adverse Effects of µ‐and κ‐opiod Receptor Agonists: A Comparison of Morphine and U50488‐H
- Conformational analysis and automated Receptor docking of selective arylacetamide-based κ–opiod agonists
- Beneficial effects of the κ opiod Receptor agonist U-50488H in experimental acute brain and spinal cord injury
- Effect of κ–opiod Receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells
- An improved antagonist radiotracer for the κ–opiod Receptor: Synthesis and characterization of 11C-LY2459989
- κ–opiod Receptor agonists modulate visceral nociception at a novel, peripheral site of action
- Visualizing preference of G protein-coupled Receptor kinase 3 for the process of κ–opiod Receptor sequestration
- μ-, δ-and κ–opiod Receptor-mediated inhibition of neurotransmitter release and adenylate cyclase activity in rat brain slices: studies with fentanyl isothiocyanate
- Sex difference in κ–opiod Receptor (KOPR)-mediated behaviors, brain region KOPR level and KOPR-mediated guanosine 5′-O-(3-[35S] thiotriphosphate) binding in …
- Early role of the κ opiod Receptor in ethanol-induced reinforcement
- Structure–Activity Relationships of [des-Arg7]Dynorphin A Analogues at the κ opiod Receptor
- Prodynorphin and κ opiod Receptor mRNA expression in the cingulate and prefrontal cortices of subjects diagnosed with schizophrenia or affective disorders
- Post-transcriptional regulation of mouse κ–opiod Receptor expression
- Trial-selective effects of U50, 488H, a κ–opiod Receptor agonist, on consummatory successive negative contrast
- Development and in vivo evaluation of a κ–opiod Receptor agonist as a PET radiotracer with superior imaging characteristics
- Anti-arrhythmic effect of κ–opiod Receptor stimulation in the perfused rat heart: involvement of a cAMP-dependent pathway
- Anti‐nociception mediated by a κ opiod Receptor agonist is blocked by a δ Receptor agonist
- Voluntary ethanol intake predicts κ–opiod Receptor supersensitivity and regionally distinct dopaminergic adaptations in macaques
- Spinal κ–opiod Receptor-mediated antinociception is stimulus-specific
- Characterization of a Knock-In Mouse Line Expressing a Fusion Protein of κ opiod Receptor Conjugated with tdTomato: 3-Dimensional Brain Imaging via …
- Neuroanatomical and neuropharmacological study of opiod pathways in the mesencephalic tectum: effect of μ1-and κ–opiod Receptor blockade on escape behavior …
- Regulation of κ–opiod Receptor signaling in peripheral sensory neurons in vitro and in vivo
- Activity profiles of dalargin and its analogues in μ‐, δ‐ and κ‐opiod Receptor selective bioassays
- Elucidation of conformational states, dynamics, and mechanism of binding in human κ–opiod Receptor complexes
- Modeling of κ–opiod Receptor/agonists interactions using pharmacophore-based and docking simulations
- Prenatal ethanol increases ethanol intake throughout adolescence, alters ethanol‐mediated aversive learning, and affects μ but not δ or κ opiod Receptor mRNA …
- Presence of μ and κ opiod Receptor mRNAs in galanin but not in GnRH neurons in the female rat
- Prolonged opportunity for ischemic neuroprotection with selective κ–opiod Receptor agonist in rats
- Hyaluronic acid induces activation of the κ–opiod Receptor
- The novel κ–opiod Receptor agonist TRK-820 suppresses the rewarding and locomotor-enhancing effects of morphine in mice
- Characterization of κ–opiod Receptor transcripts expressed by T cells and macrophages
- 8-epi-Salvinorin B: crystal structure and affinity at the κ opiod Receptor
- Suppression of cAMP by phosphoinositol/Ca2+ pathway in the cardiac κ–opiod Receptor
- Endogenous κ opiod Receptor Systems Modulate the Responsiveness of Mesoaccumbal Dopamine Neurons to Ethanol
- Effects of κ–opiod Receptor agonists on long-term cocaine use and dopamine neurotransmission
- Blockade of U50, 488H analgesia by antisense oligodeoxynucleotides to a κ–opiod Receptor
- Intrinsic relative activities of κ opiod agonists in activating Gα proteins and internalizing Receptor: Differences between human and mouse Receptors
- … of CYX-6, a potent μ-opiod Receptor agonist, a δ-and κ–opiod Receptor antagonist and a biased ligand at μ, δ & κ–opiod Receptors, evokes antinociception with …
- U-50,488 H, a κ–opiod Receptor agonist, markedly prevents memory dysfunctions induced by transient cerebral ischemia in mice
- Butorphanol dependence increases hippocampal κ‐opiod Receptor gene expression
- Buprenorphine is an Antagonist at the ϰ opiod Receptor
- κ–opiod Receptor modulation of accumbal dopamine concentration during operant ethanol self-administration
- Effects of κ‐opiod Receptor stimulation in the heart and the involvement of protein kinase C
- Differential effects of μ-, δ-, and κ–opiod Receptor agonists on mechanosensitive gastric vagal afferent fibers in the rat
- Antisense oligodeoxynucleotide to a δ-opiod Receptor selectivily blocks the spinal antinociception induced by δ-, but not μ-or κ–opiod Receptor agonists in the mouse
- The protective effects of κ–opiod Receptor stimulation in hypoxic pulmonary hypertension involve inhibition of autophagy through the AMPK-MTOR pathway
- Response of neuropeptide Y-induced feeding to μ-, δ-and κ–opiod Receptor antagonists in the neonatal chick
- Design of a stable cyclic peptide analgesic derived from sunflower seeds that targets the κ–opiod Receptor for the treatment of chronic abdominal pain
- Effect of repeated administration of TRK-820, a κ–opiod Receptor agonist, on tolerance to its antinociceptive and sedative actions
- Tyrosine phosphorylation of Kir3 following κ–opiod Receptor activation of p38 MAPK causes heterologous desensitization
- Design, synthesis and biological evaluation of aminobenzyloxyarylamide derivatives as selective κ opiod Receptor antagonists
- Roles of KATP channels in delayed cardioprotection and intracellular Ca2+ in the rat heart as revealed by κ‐opiod Receptor stimulation with U50,488H
- N-methylacetamide analog of salvinorin A: a highly potent and selective κ–opiod Receptor agonist with oral efficacy
- Localization of κ–opiod Receptor mRNA in neuronal subpopulations of rat sensory ganglia and spinal cord
- κ–opiod Receptor activation protects against myocardial ischemia-reperfusion injury via AMPK/Akt/eNOS signaling activation
- Analyzing interaction of μ-, δ-and κ–opiod Receptor gene variants on alcohol or drug dependence using a pattern discovery-based method
- … morphine administration causes differential long-lasting changes in dopaminergic neurotransmission in rat striatum without changing its δ-and κ–opiod Receptor …
- NMR and modeling studies of a synthetic extracellular loop II of the κ opiod Receptor in a DPC micelle
- Down-regulation of the tumour suppressor κ–opiod Receptor predicts poor prognosis in hepatocellular carcinoma patients
- Syntheses of immobilized G protein-coupled Receptor chromatographic stationary phases: characterization of immobilized μ and κ opiod Receptors
- Determination of sites of U50, 488H-promoted phosphorylation of the mouse κ opiod Receptor (KOPR): disconnect between KOPR phosphorylation and internalization
- Cloning and promoter mapping of mouse κ opiod Receptor gene
- Central and peripheral actions of the novel κ‐opiod Receptor agonist, EMD 60400
- Mouse κ–opiod Receptor mRNA differential transport in neurons
- Electroacupuncture relieves labour pain and influences the spinal dynorphin/κ–opiod Receptor system in rats
- Novel 18F-labeled κ–opiod Receptor antagonist as PET radiotracer: synthesis and in vivo evaluation of 18F-LY2459989 in nonhuman primates
- Effects of salvinorin A, a κ–opiod hallucinogen, on a neuroendocrine biomarker assay in nonhuman primates with high κ–Receptor homology to humans
- … -50/Na+/H+ exchanger regulatory factor (EBP50/NHERF) blocks U50, 488H-induced down-regulation of the human κ opiod Receptor by enhancing its …
- κ–opiod Receptor gene as a predictor of response in a cocaine vaccine clinical trial
- Differential regulation of the human κ opiod Receptor by agonists: etorphine and levorphanol reduced dynorphin A-and U50, 488H-induced internalization and …
- Effects of the local administration of selective μ-, δ-and κ–opiod Receptor agonists on osteosarcoma-induced hyperalgesia
- μ‐opiod Agonist Inhibition of κ‐opiod Receptor‐Stimulated Extracellular Signal‐Regulated Kinase Phosphorylation Is Dynamin‐Dependent in C6 Glioma Cells
- Comparison of G-protein activation in the brain by μ-, δ-, and κ–opiod Receptor agonists in μ-opiod Receptor knockout mice
- Drug design and synthesis of a novel κ opiod Receptor agonist with an oxabicyclo [2.2. 2] octane skeleton and its pharmacology
- Distribution of κ‐opiod Receptor in the Pulmonary Artery and its Changes During Hypoxia
- Neuroprotective κ–opiod Receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats
- Cu-Catalyzed N-arylation of oxazolidinones: An efficient synthesis of the κ–opiod Receptor agonist CJ-15161
- Novel malonamide derivatives as potent κ opiod Receptor agonists
- Changes in the brain κ–opiod Receptor levels of rats in withdrawal from physical dependence upon butorphanol
- Effects of heat shock protein 70 activation by metabolic inhibition preconditioning or κ–opiod Receptor stimulation on Ca2+ homeostasis in rat ventricular myocytes …
- Identification of arodyn, a novel acetylated dynorphin A-(1− 11) analogue, as a κ opiod Receptor antagonist
- Effects of intrathecal κ–opiod Receptor agonist on morphine-induced itch and antinociception in mice
- μ but not δ and κ opiod Receptor involvement in ventrolateral orbital cortex opiod-evoked antinociception in formalin test rats
- Quaternary ammonium salt of U50488H, a new κ–opiod Receptor agonist, protects rat heart against ischemia/reperfusion injury
- Heterologous µ‐opiod Receptor adaptation by repeated stimulation of κ‐opiod Receptor: up‐regulation of G‐protein activation and antinociception
- In vivo and in vitro characterization of naltrindole-derived ligands at the κ–opiod Receptor
- Effects of morphine in rats treated chronically with U-50,488 H, a κ opiod Receptor agonist
- Peripheral component in the enhanced antinociceptive effect of systemic U-69,593, a κ–opiod Receptor agonist in mononeuropathic rats
- Changes in spinal δ and κ opiod systems in mice deficient in the A2A Receptor gene
- Stimulation of mitogen-activated protein kinase kinases (MEK1/2) by μ-, δ-and κ–opiod Receptor agonists in the rat brain: Regulation by chronic morphine and opiod …
- Gastric effects of μ-, δ-and κ–opiod Receptor agonists on brainstem unitary responses in the neonatal rat
- δ, μ, and κ opiod Receptor agonists inhibit dopamine overflow in rat neostriatal slices
- Pharmacological properties of R-84760, a novel κ–opiod Receptor agonist
- Amygdalar κ–opiod Receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opiod abstinence
- Complete knockout of the nociceptin/orphanin FQ Receptor in the rat does not induce compensatory changes in μ, δ and κ opiod Receptors
- Determination of the in vivo selectivity of a new κ–opiod Receptor antagonist PET tracer 11C-LY2795050 in the rhesus monkey
- Highly potent and selective new diphenethylamines interacting with the κ–opiod Receptor: synthesis, pharmacology, and structure–activity relationships
- Analysis of the antinociceptive actions of the κ–opiod agonist enadoline (CI-977) in neonatal and adult rats: comparison to κ–opiod Receptor mRNA ontogeny
- Antinociceptive effect of a κ–opiod Receptor agonist that minimally crosses the blood-brain barrier (ICI 204448) in a rat model of mononeuropathy
- Chronic food restriction alters μ and κ opiod Receptor binding in the parabrachial nucleus of the rat: a quantitative autoradiographic study
- Agonist-Dependent and-Independent κ opiod Receptor phosphorylation: distinct phosphorylation patterns and different cellular outcomes
- Increased responsiveness of mesolimbic and mesostriatal dopamine neurons to cocaine following repeated administration of a selective κ‐opiod Receptor agonist
- κ–opiod Receptor effects of butorphanol in rhesus monkeys
- The association of genetic polymorphisms in the κ–opiod Receptor 1 gene with body weight, alcohol use, and withdrawal symptoms in patients with methadone …
- Chronic cocaine increases κ‐opiod Receptor density: Lack of effect by selective dopamine uptake inhibitors
- N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: Selective and Nonbasic κ–opiod Receptor Ligands
- κ–opiod Receptor blockade with nor-binaltorphimine modulates cocaine self-administration in drug-naive rats
- Effects of κ–opiod Receptor activation on myocardium
- Discovery of a Highly Selective and Potent κ opiod Receptor Agonist from N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced …
- Up-regulation of RGS4 mRNA by opiod Receptor agonists in PC12 cells expressing cloned μ-or κ–opiod Receptors
- Antisense confirmation of μ-and κ–opiod Receptor mediation of morphine’s effects on body temperature in rats
- A highly selective κ–opiod Receptor agonist with low addictive potential and dependence liability
- Studies of dual promoters of mouse κ–opiod Receptor gene
- Enadoline, a selective κ–opiod Receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain
- κ–opiod Receptor stimulation reduces palmitate-induced apoptosis via Akt/eNOS signaling pathway
- Xylazine induced central antinociception mediated by endogenous opiods and μ-opiod Receptor, but not δ-or κ–opiod Receptors
- Purification and mass spectrometric analysis of the κ opiod Receptor
- κ–opiod Receptor stimulation improves endothelial function via Akt-stimulated NO production in hyperlipidemic rats
- Ischemic neuroprotection with selective κ–opiod Receptor agonist is gender specific
- κ–opiod Receptor as a key mediator in the regulation of appetitive 50-kHz ultrasonic vocalizations
- [11C]-MeJDTic: a novel radioligand for κ–opiod Receptor positron emission tomography imaging
- Novel signaling of dynorphin at κ–opiod Receptor/bradykinin B2 Receptor heterodimers
- … helical orientations among related G protein-coupled Receptors provide a novel mechanism for selectivity: studies with salvinorin A and the κ–opiod Receptor
- κ opiod Receptor activation in different brain regions differentially modulates anxiety-related behaviors in mice
- Involvement of the κ–opiod Receptor in nitrous oxide-induced analgesia in mice
- Dissociable effects of the κ–opiod Receptor agonists bremazocine, U69593, and U50488H on locomotor activity and long-term behavioral sensitization induced by …
- Synthesis of an affinity ligand (‘UPHIT’) for in vivo acylation of the κ–opiod Receptor
- opiods in cancer: The κ‑opiod Receptor
- Netrin-1 signaling regulates de novo protein synthesis of κ opiod Receptor by facilitating polysomal partition of its mRNA
- Differential effects of μ-, δ-and κ–opiod Receptor agonists on the discriminative stimulus properties of cocaine in rats
- κ–opiod Receptor stimulation increases intracellular free calcium in isolated rat ventricular myocytes
- κ–opiod Receptor in the nucleus is a novel prognostic factor of esophageal squamous cell carcinoma
- Effects of JDTic, a selective κ–opiod Receptor antagonist, on the development and expression of physical dependence on morphine using a rat continuous-infusion …
- Effects of Peripheral μ, δ, and κ–opiod Receptor Agonists on the Levels of Anxiety and Motor Activity of Rats
- Differential κ–opiod Receptor expression on mouse lymphocytes at varying stages of maturation and on mouse macrophages after selective elicitation
- Modulation of glutamate release by a κ–opiod Receptor agonist in rodent and primate striatum
- Azepinone as a conformational constraint in the design of κ–opiod Receptor agonists
- Anticonvulsive effects of κ‐opiod Receptor modulation in an animal model of ethanol withdrawal
- κ–opiod Receptor stimulation improves endothelial function in hypoxic pulmonary hypertension
- Plant-Derived Cyclotides Modulate κ–opiod Receptor Signaling
- Modulation of humoral immune response by central administration of leucine-enkephalin: Effects of μ, δ and κ opiod Receptor antagonists
- 2, 4-Substituted bispidines as rigid hosts for versatile applications: from κ–opiod Receptor to metal coordination
- Anti-arrhythmic effects of κ–opiod Receptor and its changes in ischemia and reperfusion
- κ–opiod Receptor ligands inhibit cocaine-induced HIV-1 expression in microglial cells
- μ and κ opiod Receptor distribution in the monogamous titi monkey (Callicebus cupreus): Implications for social behavior and endocrine functioning
- [Nα-BenzylTyr,cyclo(d-Asp5,Dap8)]- dynorphin A-(1−11)NH2 Cyclized in the “Address” Domain Is a Novel κ–opiod Receptor Antagonist
- Effects of U-50,488 H, a κ–opiod Receptor agonist, on the learned helplessness model of depression in mice
- The selective κ–opiod Receptor agonist U50, 488 reduces L-dopa-induced dyskinesias but worsens parkinsonism in MPTP-treated primates
- Evidence for coupling of the κ opiod Receptor to brain GTPase
- A novel κ–opiod Receptor agonist, TRK-820, blocks the development of physical dependence on morphine in mice
- κ–opiod Receptor signals through Src and focal adhesion kinase to stimulate c-Jun N-terminal kinases in transfected COS-7 cells and human monocytic THP-1 cells
- Ligands regulate cell surface level of the human κ opiod Receptor by activation-induced down-regulation and pharmacological chaperone-mediated enhancement …
- Reactive oxygen species (ROS) generation is stimulated by κ opiod Receptor activation through phosphorylated c-Jun N-terminal kinase and inhibited by p38 …
- The effect of activated κ–opiod Receptor (κ-OR) on the role of calcium sensing Receptor (CaSR) in preventing hypoxic pulmonary hypertension development
- κ–opiod Receptor mediates the antinociceptive effect of nitrous oxide in mice
- Retinoic acid-induced chromatin remodeling of mouse κ opiod Receptor gene
- Antagonism of κ opiod Receptor in the nucleus accumbens prevents the depressive-like behaviors following prolonged morphine abstinence
- κ–opiod Receptor model in a phospholipid bilayer: Molecular dynamics simulation
- Cardioprotection with κ–opiod Receptor stimulation is associated with a slowing of cross-bridge cycling
- Influence of asimadoline, a new κ‐opiod Receptor agonist, on tubular water absorption and vasopressin secretion in man
- Peripheral neuronal nitric oxide synthase activity mediates the antinociceptive effect of Crotalus durissus terrificus snake venom, a δ-and κ–opiod Receptor agonist
- The adrenergic Receptor agonist, clonidine, potentiates the anti‐parkinsonian action of the selective κ‐opiod Receptor agonist, enadoline, in the monoamine‐depleted …
- Amygdala dynorphin/κ opiod Receptor system modulates depressive-like behavior in mice following chronic social defeat stress
- RGS2 and RGS4 proteins: New modulators of the κ–opiod Receptor signaling
- Disability of development of tolerance to morphine and U-50,488 H, a selective κ–opiod Receptor agonist, in neuropathic pain model mice
- … effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: Participation of the κ–opiod Receptor and …
- κ–opiod regulation of thymocyte IL-7 Receptor and CC chemokine Receptor 2 expression
- Synthesis and Pharmacological Evaluation of Fluorinated Quinoxaline‐Based κ‐opiod Receptor (KOR) Agonists Designed for PET Studies
- Variants of κ–opiod Receptor gene and mRNA in alcohol-preferring and alcohol-avoiding mice
- Differentiation of δ, μ, and κ opiod Receptor agonists based on pharmacophore development and computed physicochemical properties
- The anticonvulsant action of CI-977, a selective κ–opiod Receptor agonist: a possible involvement of the glycine/NMDA Receptor complex
- A novel signaling pathway of nitric oxide on transcriptional regulation of mouse κ opiod Receptor gene
- … to confer cardioprotection and to increase the expression of heat-shock protein 70 by preconditioning with a κ–opiod Receptor agonist during ischaemia and …
- Effect of μ and κ opiod Receptor agonists on rat plasma corticosterone levels
- Activity of the δ-opiod Receptor is partially reduced, whereas activity of the κ–Receptor is maintained in mice lacking the μ-Receptor
- … neurotoxicity in mice via upregulation of dynorphin-mediated κ–opiod Receptor and downregulation of substance P-mediated neurokinin 1 Receptor
- Tyrosine phosphorylation of the κ–opiod Receptor regulates agonist efficacy
- Current κ opiod Receptor ligands and discovery of a new molecular scaffold as a κ opiod Receptor antagonist using pharmacophore-based virtual screening
- … of GEC1 protein and γ-aminobutyric acid type A (GABAA) Receptor-associated protein (GABARAP), two microtubule-associated proteins, on κ opiod Receptor …
- Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective κ–opiod Receptor Agonists with Anti-Inflammatory Activity in Vivo
- Discovery of peripheral κ–opiod Receptor agonists as novel analgesics
- GEC1-κ opiod Receptor binding involves hydrophobic interactions: GEC1 has chaperone-like effect
- Molecular modeling study of the differential ligand–Receptor interaction at the μ, δ and κ opiod Receptors
- Study of the involvement of K+ channels in the peripheral antinociception of the κ–opiod Receptor agonist bremazocine
- Regulation of mouse κ opiod Receptor gene expression by different 3′-untranslated regions and the effect of retinoic acid
- κ–opiod Receptor is involved in the cardioprotection induced by exercise training
- The G‐protein biased partial κ opiod Receptor agonist 6′‐GNTI blocks hippocampal paroxysmal discharges without inducing aversion
- … behavior in MRL/lpr mice, a possible model for pruritus in autoimmune diseases, and antipruritic activity of a novel κ–opiod Receptor agonist nalfurafine hydrochloride
- The μ-opiod activity of κ–opiod Receptor agonist compounds in the guinea pig ileum
- Cellular distribution of the mRNA for the κ–opiod Receptor in the human neocortex: a non-isotopic in situ hybridization study
- In Vivo Modulation of Post‐Spike Excitability in Vasopressin Cells by κ‐opiod Receptor Activation
- Topical κ‐opiod Receptor agonist asimadoline improves dermatitis in a canine model of atopic dermatitis
- Lack of effect of γ-hydroxybutyrate on μ, δ and κ opiod Receptor binding
- Role of κ—opiod Receptor in Hypoxic Pulmonary Artery Hypertension and Its Underlying Mechanism
- Treatment of cocaine craving with as-needed nalmefene, a partial κ opiod Receptor agonist: first clinical experience
- G protein coupled Receptor kinase-2 upregulation causes κ–opiod Receptor desensitization in diabetic heart
- Identity of the putative δ1-opiod Receptor as a δ–κ heteromer in the mouse spinal cord
- U-50488H, a selective κ–opiod Receptor agonist, improves carbon monoxide-induced delayed amnesia in mice
- A population pharmacokinetic and pharmacodynamic study of a peripheral κ–opiod Receptor agonist CR665 and oxycodone
- Protein kinase C-ε is a trigger of delayed cardioprotection against myocardial ischemia of κ–opiod Receptor stimulation in rat ventricular myocytes
- μ-and κ–opiod Receptor agonists produce peripheral inhibition of neurogenic plasma extravasation in rat skin
- A highly selective κ–opiod Receptor agonist, CI-977, reduces excitatory synaptic potentials in the rat locus coeruleus in vitro
- κ–opiod Receptor inhibition of calcium oscillations in spinal cord neurons
- A select set of opiod ligands induce up-regulation by promoting the maturation and stability of the rat κ–opiod Receptor in human embryonic kidney 293 cells
- Synthesis, biological evaluation, and Receptor docking simulations of 2-[(acylamino) ethyl]-1, 4-benzodiazepines as κ–opiod Receptor agonists endowed with …
- Modulation of the Neurotoxic Effects of Methamphetamine by the Selective κ‐opiod Receptor Agonist U69593
- Investigation of the μ‐and κ‐opiod Receptor activation by eight new synthetic opiods using the [35S]‐GTPγS assay: U‐47700, isopropyl U‐47700, U‐49900, U …
- Novel κ–opiod Receptor agonist MB-1C-OH produces potent analgesia with less depression and sedation
- Activation of the κ–opiod Receptor in Caco-2 cells decreases interleukin-8 secretion
- Inhibitory and excitatory effects of μ-, δ-, and κ–opiod Receptor activation on breathing in awake turtles, Trachemys scripta
- Neurofilament proteins and cAMP pathway in brains of μ-, δ-or κ–opiod Receptor gene knock-out mice: effects of chronic morphine administration
- Design, synthesis and biological evaluation of N-hydroxy-aminobenzyloxyarylamide analogues as novel selective κ opiod Receptor antagonists
- κ opiod Receptor interacts with Na+/H+-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) to stimulate Na+ …
- Stress-induced epigenetic regulation of κ–opiod Receptor gene involves transcription factor c-Myc
- κ–opiod Receptor stimulation inhibits growth of neonatal rat ventricular myocytes
- Synthesis and evaluation of novel peripherally restricted κ–opiod Receptor agonists
- The novel κ–opiod Receptor agonist TRK-820 has no affect on the development of antinociceptive tolerance to morphine in mice
- Butorphanol alleviates lipopolysaccharide‑induced inflammation and apoptosis of cardiomyocytes via activation of the κ‑opiod Receptor
- The κ–opiod Receptor is involved in the stimulating effect of nicotine on adrenocortical activity but not in nicotine induced anxiety
- Functional evidence for interaction between prostaglandin EP3 and κ–opiod Receptor pathways in tactile pain induced by human immunodeficiency virus type-1 (HIV-1 …
- Arylacetamide κ–opiod Receptor agonists produce a tonic-and use-dependent block of tetrodotoxin-sensitive and-resistant sodium currents in colon sensory neurons
- Potentiation of κ–opiod Receptor agonist-induced analgesia and hypothermia by fluoxetine
- Apparent efficacy of κ–opiod Receptor ligands on serum prolactin levels in rhesus monkeys
- Blockade of the morphine-induced increase in turnover of dopamine on the mesolimbic dopaminergic system by κ–opiod Receptor activation in mice
- Synthesis and absolute configuration of optically pure enantiomers of a ϰ‐opiod Receptor selective agonist
- Na+ ions and Gpp (NH) p selectively inhibit agonist interactions at μ-and κ–opiod Receptor sites in rabbit and guinea-pig cerebellum membranes
- Effects of μ-, δ-and κ–opiod Receptor agonists on methamphetamine-induced self-injurious behavior in mice
- Early ontogeny of κ–opiod Receptor regulation of prolactin secretion in the rat
- Separation of κ–opiod Receptor subtype from frog brain
- Transcriptional regulation of the major HIV‐1 coReceptor, CXCR4, by the κ opiod Receptor
- κ–opiod Receptor stimulation inhibits cardiac hypertrophy induced by β1-adrenoceptor stimulation in the rat
- The effect of κ–opiod Receptor agonists on tetrodotoxin-resistant sodium channels in primary sensory neurons
- The role of phosphodiesterase in mediating the effect of protein kinase C on cyclic AMP accumulation upon κ–opiod Receptor stimulation in the rat heart
- Synthesis and pharmacology of a novel κ opiod Receptor (KOR) agonist with a 1, 3, 5-trioxazatriquinane skeleton
- Mitochondrial dysfunction and apoptosis are attenuated on κ–opiod Receptor activation through AMPK/GSK-3β pathway after myocardial ischemia and reperfusion
- Expression of κ–opiod Receptor mRNA in human peripheral blood lymphocytes and the relationship between its expression and the inflammatory changes in …
- Impaired [Ca2+]i and pHiresponses to κ–opiod Receptor stimulation in the heart of chronically hypoxic rats
- Discovery of N-methyltetrahydroprotoberberines with κ–opiod Receptor agonists-opiod Receptor agonist activities from corydalis yanhusuo WT Wang by using two …
- Spontaneous excitatory currents and κ–opiod Receptor inhibition in dentate gyrus are increased in the rat pilocarpine model of temporal lobe epilepsy
- Nalfurafine hydrochloride, a selective κ opiod Receptor agonist, has no reinforcing effect on intravenous self-administration in rhesus monkeys
- … 17-cyclopropylmethyl-3, 14β-dihydroxy-4, 5α-epoxy-6β-[(4′-pyridyl) carboxamido] morphinan (NAP) derivatives as μ/κ opiod Receptor dual selective ligands
- Regulation of κ–opiod Receptor mRNA level by cyclic AMP and growth factors in cultured rat glial cells
- Structural determinants of diphenethylamines for interaction with the κ opiod Receptor: Synthesis, pharmacology and molecular modeling studies
- Baicalein protects chicken embryonic cardiomyocyte against hypoxia–reoxygenation injury via μ-and δ-but not κ–opiod Receptor signaling
- Effects of U-69,593, a κ–opiod Receptor agonist, on carrageenin-induced peripheral oedema and Fos expression in the rat spinal cord
- κ–opiod Receptor potentiates apoptosis via a phospholipase C pathway in the CNE2 human epithelial tumor cell line
- Cholecystokinin octapeptide reverses the κ–opiod–Receptor-mediated depression of calcium current in rat dorsal root ganglion neurons
- κ–opiod Receptor antagonism reverses heroin withdrawal-induced hyperalgesia in male and female rats
- Hypericum perforatum inhibits the binding of μ-and κ–opiod Receptor expressed with the Semliki Forest virus system
- Hypertensive state, independent of hypertrophy, exhibits an attenuated decrease in systolic function on cardiac κ–opiod Receptor stimulation
- Effects of acute agonist treatment on subcellular distribution of κ opiod Receptor in rat spinal cord
- κ–opiod Receptor modulation of GABAergic inputs onto ventrolateral periaqueductal gray dopamine neurons
- Arylacetamide κ opiod Receptor agonists with reduced cytochrome P450 2D6 inhibitory activity
- µ-and κ–opiod Receptor activation in the dorsal periaqueductal grey matter differentially modulates panic-like behaviours induced by electrical and chemical …
- κ–opiod Receptor stimulation inhibits augmentation of Ca2+ transient and hypertrophy induced by isoprenaline in neonatal rat ventricular myocytes—Role of …
- Effects of ibogaine on the development of tolerance to antinociceptive action of μ-, δ-and κ–opiod Receptor agonists in mice
- Effect of μ, δ and κ opiod Receptor agonists on a reactive oxygen species mediated model of skin inflammation
- κ–opiod Receptor agonist-induced prolactin release in primates is blocked by dopamine D2-like Receptor agonists
- Gi1 and GoA differentially determine kinetic efficacies of agonists for κ–opiod Receptor
- The NMDA Receptor antagonist MK-801 differentially modulates μ and κ opiod actions in spinal cord in vitro
- The κ–opiod Receptor expressed on the mouse lymphoma cell line R1. 1 contains a sulfhydryl group at the binding site
- … to a δ-opiod Receptor messenger rna selectively blocks the antinociception induced by intracerebroventricularly administered δ-, but not μ-, ϵ-, or κ–opiod Receptor …
- Conformationally restricted κ–opiod Receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines
- Effects of ibogaine and noribogaine on the antinociceptive action of μ-, δ-and κ–opiod Receptor agonists in mice
- Dual regulation by μ, δ and κ opiod Receptor agonists of K+ conductance of DRG neurons and neuroblastoma× DRG neuron hybrid F11 cells
- Decrease of κ–opiod Receptor mRNA level in ventral tegmental area of male mice after repeated experience of aggression
- Effect of U50, 488H, a κ–opiod Receptor agonist on myocardial α-and β-myosin heavy chain expression and oxidative stress associated with isoproterenol-induced …
- Generalization of NMDA-Receptor antagonists to the discriminative stimulus effects of κ–opiod Receptor agonists U-50,488 H, but not TRK-820 in rats
- Effect of κ–opiod Receptor agonists on morphine analgesia in morphine-naive and morphine-tolerant rats
- κ–opiod Receptor activation prevents against arrhythmias by preserving Cx43 protein via alleviation of intracellular calcium
- κ–opiod Receptor stimulation induces arrhythmia in the isolated rat heart via the protein kinase C/Na+–H+ exchange pathway
- κ–opiod Receptor agonist protects against ischemic reduction of 2-deoxyglucose uptake in morphine-tolerant rats
- Endomorphin-1 Discriminates the μ-opiod Receptor From the δ-and κ–opiod Receptors by Recognizing the Difference in Multiple Regions
- Efficacy and safety of a new κ–opiod Receptor agonist for the treatment of uremic pruritus
- Effect of dizocilpine (MK-801) on analgesia and tolerance induced by U-50,488 H, a κ–opiod Receptor agonist, in the mouse
- Effects of spiradoline mesylate, a selective κ–opiod–Receptor agonist, on the central dopamine system with relation to mouse locomotor activity and analgesia
- Mechanisms involved in the hypotensive effect of a κ–opiod Receptor agonist in hypertensive rats
- Promoter activity of mouse κ opiod Receptor gene in transgenic mouse
- Peripheral administration of κ–opiod Receptor antagonist stimulates gonadotropin-releasing hormone pulse generator activity in ovariectomized, estrogen-treated …
- Efficient synthesis of the κ–opiod Receptor agonist CJ-15,161: four stereospecific inversions at a single aziridinium stereogenic center
- Induction of the mouse κ–opiod Receptor gene by retinoic acid in P19 cells
- PRO‐AND ANTI‐ARRHYTHMIC EFFECTS OF A κ opiod Receptor AGONIST: A MODEL FOR THE BIPHASIC ACTION OF A LOCAL HORMONE IN THE HEART
- κ opiod Receptor stimulation of [35S] GTPγS binding in guinea pig brain
- Chronic U50, 488H abolishes inositol 1, 4, 5-trisphosphate and intracellular Ca2+ elevations evoked by κ–opiod Receptor in rat myocytes
- … M-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ–opiod Receptor Agonist with an …
- The κ–opiod Receptor antagonist JDTic decreases ethanol intake in alcohol-preferring AA rats
- Central monoaminergic mechanisms in mice and analgesic activity of spiradoline mesylate, a selective κ–opiod Receptor agonist
- Prospects of using of κ–opiod Receptor agonists U-50,488 and ICI 199,441 for improving heart resistance to ischemia/reperfusion
- Contralateral, ipsilateral and bilateral treatments with the κ–opiod Receptor agonist U-50,488 H in mononeuropathic rats
- Diminution of contractile response by κ–opiod Receptor agonists in isolated rat ventricular cardiomyocytes is mediated via a pertussis toxin-sensitive G protein
- [Pro3]Dyn A(1−11)-NH2: A Dynorphin Analogue with High Selectivity for the κ opiod Receptor
- Analogs of the κ opiod Receptor antagonist arodyn cyclized by ring-closing metathesis retain κ opiod Receptor affinity, selectivity and κ opiod Receptor antagonism
- N-substituted 4β-methyl-5-(3-hydroxyphenyl)-7α-amidomorphans are potent, selective κ opiod Receptor antagonists
- Differential effects of μ-opiod, δ-opiod and κ–opiod Receptor agonists on dopamine Receptor agonist-induced climbing behavior in mice
- Coupling of the cloned rat κ–opiod Receptor to adenylyl cyclase is dependent on Receptor expression
- The amygdala mediates the impairing effect of the selective κ–opiod Receptor agonist U-50,488 on memory in CD1 mice
- κ–opiod Receptor agonist inhibition of HIV-1 envelope glycoprotein-mediated membrane fusion and CXCR4 expression on CD4+ lymphocytes
- Behavioral characterization of κ opiod Receptor agonist spiradoline and cannabinoid Receptor agonist CP55940 mixtures in rats
- The κ–opiod Receptor agonist U50, 488H induces acute physical dependence in guinea-pigs
- Antagonism of the morphine-induced Straub tail reaction by κ–opiod Receptor activation in mice
- Activation of κ–opiod Receptor by U50, 488H improves vascular dysfunction in streptozotocin-induced diabetic rats
- Comparative effects of selective κ–opiod Receptor agonists on dopamine levels in the dorsal caudate of freely moving rats
- Modification of κ–opiod Receptor agonist-induced antinociception by diabetes in the mouse brain and spinal cord
- Process research and scale-up of the κ–opiod Receptor agonist CJ-15,161 drug candidate
- Participation of dorsal periaqueductal gray 5-HT1A Receptors in the panicolytic-like effect of the κ–opiod Receptor antagonist Nor-BNI
- κ‐opiod Receptor‐mediated enhancement of the hyperpolarization‐activated current (Ih) through mobilization of intracellular calcium in rat nucleus raphe magnus
- μ-, δ-and κ–opiod Receptor agonists do not alter the discriminative stimulus effects of cocaine or d-amphetamine in rats
- κ opiod Receptor 1 single nucleotide polymorphisms were associated with the methadone dosage
- Selective natural κ opiod and cannabinoid Receptor agonists with a potential role in the treatment of gastrointestinal dysfunction-Analogues of salvinorin A, an …
- κ–opiod Receptor antagonism improves recovery from myocardial stunning in chronically instrumented dogs
- Replacing a Palatable High-Fat Diet with a Low-Fat Alternative Heightens κ–opiod Receptor Control over Nucleus Accumbens Dopamine
- Serotonergic and GABAergic neurons in the medial rostral ventral medulla express κ–opiod Receptor immunoreactivity
- Combination of cyclohexane and piperazine based κ–opiod Receptor agonists: synthesis and pharmacological evaluation of trans, trans-configured …
- μ-but not δ-and κ–opiod Receptor mediates the nucleus submedius interferon-α-evoked antinociception in the rat
- Specific κ opiod Receptor agonists
- Precipitated κ–opiod Receptor agonist withdrawal increases glutamate in rat locus coeruleus
- Roles of residues 3 and 4 in cyclic tetrapeptide ligand recognition by the κ‐opiod Receptor
- N-[18F]-FluoropropylJDTic for κ–opiod Receptor PET imaging: Radiosynthesis, pre-clinical evaluation, and metabolic investigation in comparison with parent JDTic
- Postsynaptic and extrasynaptic localization of κ–opiod Receptor in selected brain areas of young rat and chick using an anti-Receptor monoclonal antibody
- The κ–opiod Receptor antagonist nor-BNI inhibits cocaine and amphetamine, but not cannabinoid (WIN 52212-2), abstinence-induced withdrawal in planarians: An …
- Role of protein kinase C‐epsilon in the development of κ‐opiod Receptor tolerance to U50, 488H in rat ventricular myocytes
- OFQ reverses the κ–opiod Receptor-mediated depression of calcium current in rat dorsal root ganglion neurons
- A Bivalent Ligand (KDAN-18) Containing δ-Antagonist and κ-Agonist Pharmacophores Bridges δ2 and κ1 opiod Receptor Phenotypes
- p38 mitogen-activated protein kinase activation in amygdala mediates κ opiod Receptor agonist U50, 488H-induced conditioned place aversion
- Synthesis and biological evaluation of 2-alkyl-2-methoxymethyl-salvinorin ethers as selective κ–opiod Receptor agonists
- … Receptor Docking Simulations of 2-[(Acylamino)ethyl]-1,4-benzodiazepines as Novel Tifluadom-like Ligands with High Affinity and Selectivity for κ–opiod Receptors
- The κ–opiod Receptor Agonist U-50488 Blocks Ca2+ Channels in a Voltage-and G Protein–Independent Manner in Sensory Neurons
- Chemical function-based pharmacophore generation of selective κ–opiod Receptor agonists by catalyst and phase
- κ‑opiod Receptor agonists may alleviate intestinal damage in cardiopulmonary bypass rats by inhibiting the NF‑κB/HIF‑1α pathway
- P38: The link between the κ–opiod Receptor and dysphoria
- Attenuation of the antinociceptive action of the selective κ–opiod Receptor agonist, U-50,488 H by ICS-205-930
- Synthesis and biological evaluation of dibenz [b, f][1, 5] oxazocine derivatives for agonist activity at κ–opiod Receptor
- Species differences in the effects of the κ–opiod Receptor antagonist zyklophin
- κ‐opiod Receptor binding varies inversely with tumor grade in human gliomas
- Differential effects of LY235959, a competitive antagonist of the NMDA Receptor on κ–opiod Receptor agonist induced responses in mice and rats
- Activation of κ‐opiod Receptor Exerts the Glucose‐Homeostatic Effect in Streptozotocin‐Induced Diabetic Mice
- Activation of κ–opiod Receptor inhibits inflammatory response induced by sodium palmitate in human umbilical vein endothelial cells
- Potent inhibition of alcohol self-administration in alcohol-preferring rats by a κ–opiod Receptor antagonist
- How does agonist and antagonist binding lead to different conformational ensemble equilibria of the κ–opiod Receptor: Insight from long-time gaussian accelerated …
- Differential time course of effects of κ–opiod agonist treatment on dynorphin a levels and κ–opiod Receptor density
- … combinations with intrathecal BRL52537 (κ–opiod agonist), pregabalin (calcium channel modulator), AF 353 (P2X3 Receptor antagonist), and A804598 (P2X7 Receptor …
- κ–opiod Receptor agonists improve pirenzepine-induced disturbance of spontaneous alternation performance in the mouse
- Differential antagonism of the rate-decreasing effects of κ–opiod Receptor agonists by naltrexone and norbinaltorphimine
- The κ–opiod Receptor agonist asimadoline inhibits epithelial transport in mouse trachea and colon
- Limbic brain structures are important sites of κ–opiod Receptor-mediated actions in the rat: a [14C]-2-deoxyglucose study
- κ opiod Receptor Agonist Inhibits Myocardial Injury in Heart Failure Rats through Activating Nrf2/HO-1 Pathway and Regulating Ca2+-SERCA2a
- Study of μ-and δ-opiod Activities in Agents with Various κ–Receptor Selectivity
- Isolation and Chemical Modification of Clerodane Diterpenoids from Salvia Species as Potential Agonists at the κ‐opiod Receptor
- Kinetic Modeling and Test–Retest Reproducibility of 11C-EKAP and 11C-FEKAP, Novel Agonist Radiotracers for PET Imaging of the κ–opiod Receptor in Humans
- Syntheses of potential metabolites of a potent κ–opiod Receptor agonist, TRK-820
- Pertussis and cholera toxins modulate κ–opiod Receptor agonists-induced hypothermia and gut inhibition
- κ–opiod Receptor antisense oligonucleotide injected into rat hippocampus causes hypertension
- Recent development and potential use of µ‐and κ‐opiod Receptor ligands in positron emission tomography studies
- Reversion of muscarinic autoReceptor agonist-induced acetylcholine decrease and learning impairment by dynorphin A (1–13), an endogenous κ–opiod Receptor …
- Effectiveness of nalbuphine, a κ‐opiod Receptor agonist and μ‐opiod Receptor antagonist, in the inhibition of INa, IK(M), and IK(erg) unlinked to interaction with …
- κ–opiod Receptor-mediated analgesia: hotplate temperature and sex differences
- κ–opiod Receptor stimulation alleviates rat vascular smooth muscle cell calcification via PFKFB3-lactate signaling
- Amino acid conjugates as κ opiod Receptor agonists
- Syntheses of 10-Oxo, 10α-Hydroxy, and 10β-Hydroxy Derivatives of a Potent κ–opiod Receptor Agonist, TRK-820
- Involvement of κ‐opiod Receptors in peripheral response to nerve stimulation in κ‐opiod Receptor knockout mice
- Focal κ–opiod Receptor-mediated dependence and withdrawal in the nucleus paragigantocellularis
- Chronic κ–opiod Receptor antagonism delays the rise in blood pressure in spontaneously hypertensive rats
- Differential efficacies of κ agonists to induce homologous desensitization of human κ opiod Receptor
- Age-dependent effects of κ–opiod Receptor stimulation on cocaine-induced stereotyped behaviors and dopamine overflow in the caudate–putamen: an in vivo …
- The function of calcineurin and ERK1/2 signal in the antihypertrophic effects of κ–opiod Receptor stimulation on myocardial hypertrophy induced by isoprenaline
- κ–opiod Receptor mediated antinociception in rats is dependent on the functional state of dihydropyridine-sensitive calcium channels
- N-Alkylated derivatives of [d-Pro10] dynorphin A-(1-11) are high affinity partial agonists at the cloned rat κ–opiod Receptor
- Neurokinin 1 Receptor signaling mediates sex differences in μ and κ opiod-induced enhancement of contact hypersensitivity
- Molecular simulation of dynorphin A-(1− 10) binding to extracellular loop 2 of the κ–opiod Receptor. A model for Receptor activation
- Effects of peripheral and spinal κ–opiod Receptor stimulation on the exercise pressor reflex in decerebrate rats
- κ–opiod Receptor agonist inhibits the cholera toxin-sensitive G protein in the heart
- Direct detection of neuropeptide dynorphin A binding to the second extracellular loop of the κ opiod Receptor using a soluble protein scaffold
- Inhibition of elevated arginine vasopressin secretion in response to osmotic stimulation and acute haemorrhage by U‐62066E, a κ‐opiod Receptor agonist
- Renal responses to the κ–opiod–Receptor agonist U-50488H in conscious lambs
- Tonic modulation of neurotransmitter release in the guinea-pig myenteric plexus: effect of μ and κ opiod Receptor blockade and of chronic sympathetic denervation
- 14-3-3ζ Protein regulates anterograde transport of the human κ–opiod Receptor (hKOPR)
- κ–opiod Receptor agonist U50, 488H attenuates myocardial ischemia-reperfusionvia modulating Toll-like Receptor 4/nuclear factor-κB signaling in rat
- Central antinociception induced by µ‐opiod Receptor agonist morphine, but not δ‐ or κ‐, is mediated by cannabinoid CB1 Receptor
- Dynorphin A (1–8) inhibits oxidative stress and apoptosis in MCAO rats, affording neuroprotection through NMDA Receptor and κ–opiod Receptor channels
- Indirect dopamine agonists augment the locomotor activating effects of the κ‐opiod Receptor agonist U‐50,488 in preweanling rats
- Fentanyl combined with butorphanol protects myocardial ischemia/reperfusion injury via κ–opiod Receptor-mediated Nrf2-ARE signaling
- The stereoselective κ–opiod Receptor antagonist Mr 2266 does not exhibit stereoselectivity as an antagonist at the orphan opiod (ORL1) Receptor
- Role of dopamine D1 Receptors for κ–opiod–mediated locomotor activity and antinociception during the preweanling period: a study using D1 Receptor knockout mice
- A cell-based, high-throughput homogeneous time-resolved fluorescence assay for the screening of potential κ–opiod Receptor agonists
- Novel phenylamino acetamide derivatives as potent and selective κ opiod Receptor agonists
- Dog cerebral cortex contains μ-, δ-and κ–opiod Receptors at different densities: apparent lack of evidence for subtypes of the κ–Receptor using selective radioligands
- Sensitization of the adenylyl cyclase system in cloned κ–opiod Receptor-transfected cells following sustained agonist treatment: a chimeric study using G protein αi2/αq …
- Response of rat globus pallidus neurons to microiontophoretically applied μ and κ opiod Receptor agonists
- Ultrasonic vocalizations of preweanling rats: involvement of both α2-adrenoceptor and κ–opiod Receptor systems
- Suppression of Acute Herpetic Pain-Related Responses by the κ–opiod Receptor Agonist (-)-17-Cyclopropylmethyl-3, 14β-dihydroxy-4, 5α-epoxy-6β-[N-methyl-3 …
- Evidence of involvement of the nNOS and the κ–opiod Receptor in the same intracellular network of the rat periaqueductal gray that controls morphine tolerance and …
- Effects of acute and repeated morphine treatment on κ–opiod Receptor protein levels in mesocorticolimbic system
- The κ–opiod Receptor agonist U-69593 prevents cocaine-induced phosphorylation of DARPP-32 at Thr34 in the rat brain
- Preparation and evaluation of some hydrophilic phenylacetyl-piperazines as peripherally selective κ–opiod Receptor agonists
- κ‐opiod Receptor Agonists Differentially Affect the Release of Neurohypophysial Hormones
- Mechanism of direct Cav2. 2 channel block by the κ–opiod Receptor agonist U50488H
- Synthesis and pharmacological evaluation of conformationally restricted κ–opiod Receptor agonists
- κ–opiod Receptor Agonist Ameliorates Postoperative Neurocognitive Disorder by Activating the Ca2+/CaMKII/CREB Pathway
- Major effect of pyrrolic N-benzylation in norbinaltorphimine, the selective κ–opiod Receptor antagonist
- Profiles of the antinociceptive effect of R-84760, a selective κ–opiod Receptor agonist, in the formalin test in mice
- Effect of ICI197067, a κ–opiod Receptor agonist, spinally on Aδ and C reflexes and intracerebrally on respiration
- Effect of chronic administration of U-50,488 H, a κ–opiod Receptor agonist, on central dopamine D2 Receptors of the rat
- Identification of κ-and δ-opiod Receptor transcripts in immune cells
- Effects of κ–opiod Receptor agonists on stimulated phosphoinositide hydrolysis in rat kidney
- κ‑opiod Receptor agonist, U50488H, inhibits pyroptosis through NLRP3 via the Ca2+/CaMKII/CREB signaling pathway and improves synaptic plasticity in …
- Involvement of dopamine D2 Receptor signal transduction in the discriminative stimulus effects of the κ–opiod Receptor agonist U-50,488 H in rats
- Acidosis antagonizes intracellular calcium response to κ–opiod Receptor stimulation in the rat heart
- Region-dependent G-protein activation by κ–opiod Receptor agonists in the mouse brain
- The selective κ–opiod Receptor antagonist JDTic attenuates the alcohol deprivation effect in rats
- Expression of μ-and κ-, but not δ-, opiod Receptor mRNAs is enhanced in the spinal dorsal horn of the arthritic rats
- Negative modulation of spinal κ–opiod Receptor-mediated antinociception by the µ-opiod Receptor at selective doses of (−)-pentazocine
- Gastric acid secretion by central injection of dynorphin A-(1–17), an endogenous ligand of κ–opiod Receptor, in urethane-anesthetized rats
- Interaction of Extracellular Loop II of κ–opiod Receptor (196–228) with opiod Peptide Dynorphin in Membrane Environments as Revealed by Solid State Nuclear …
- The κ–opiod Receptor agonist, U50, 488H, exerts antidystonic activity in a mutant hamster model of generalized dystonia
- Design, synthesis and biological evaluation of novel tetrahydroisoquinoline quaternary derivatives as peripheral κ–opiod Receptor agonists
- κ‑opiod Receptor agonist U50488H attenuates postoperative cognitive dysfunction of cardiopulmonary bypass rats through the PI3K/AKT/Nrf2/HO‑1 pathway
- Stimulatory effects of centrally injected κ–opiod Receptor agonists on gastric acid secretion in urethane-anesthetized rats
- Biphasic effect of a κ–opiod Receptor agonist on plasma oxytocin levels in rats
- Use of Receptor chimeras to identify small molecules with high affinity for the dynorphin A binding domain of the κ opiod Receptor
- κ–opiod Receptor stimulation increases the expression of Na+-H+ exchange gene in the heart
- Synthesis and evaluation of κ–opiod Receptor agonistic activity and antinociceptive effect of novel morphine analogues, 7α-phenyl-6α, 14α-endo-etheno …
- [125I] Dynorphin (1–8) produces a similar pattern of κ–opiod Receptor labelling to [3H] dynorphin (1–8) and [3H] etorphine in guinea pig brain: A quantitative …
- Development of κ opiod Receptor agonists by focusing on phenyl substituents of 4-dimethylamino-3-phenylpiperidine derivatives: structure–activity relationship study …
- Synergistic opiod inhibition of colonic Cl− secretion by κ–opiod Receptor agonism plus μ-opiod Receptor antagonism
- Pharmacological Characterization of Human κ/μ opiod Receptor Chimeras that Retain High Affinity for Dynorphin A
- Involvement of glutamate and γ‐amino‐butyric acid Receptor systems on gastric acid secretion induced by activation of κ‐opiod Receptors in the central nervous …
- Receptor-mediated activation of G-proteins by κ opiod agonists in frog (Rana esculenta) brain membranes
- Enantiomers of 2‐[(Acylamino) ethyl]‐1, 4‐benzodiazepines, Potent ligands of κ‐opiod Receptor: Chiral chromatographic resolution, configurational assignment, and …
- Identification of an opiod κ Receptor Subtype-Selective N-Substituent for (+)-(3R,4R)-Dimethyl-4-(3-hydroxyphenyl)piperidine
- Plasticity of signaling by spinal estrogen Receptor α, κ–opiod Receptor, and metabotropic glutamate Receptors over the rat reproductive cycle regulates spinal …
- Differential effects of acute and repeated morphine treatment on κ–opiod Receptor mRNA levels in mesocorticolimbic system
- Direct evidence for the up‐regulation of spinal µ‐opiod Receptor function after repeated stimulation of κ‐opiod Receptors in the mouse
- Activation of c-fos mRNA in the brain by the κ–opiod Receptor agonist enadoline and the NMDA Receptor antagonist dizocilpine
- κ opiod Receptor-Dynorphin Signaling in the Central Amygdala Regulates Conditioned Threat Discrimination and Anxiety
- Drug–drug interactions of a novel κ–opiod Receptor agonist, nalfurafine hydrochloride, involving the P-glycoprotein
- A Subtype of κ‐opiod Receptor Mediates Inhibition of High‐Affinity GTPase Inherent in Gi1 in Guinea Pig Cerebellar Membranes
- Effects of κ-and μ-opiod Receptor agonists on Ca2+ channels in neuroblastoma cells: involvement of the orphan opiod Receptor
- Potency enhancement of the κ–opiod Receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif
- κ–opiod Receptor-mediated thermonociceptive mechanisms in streptozotocin diabetes
- Discovery of highly selective κ–opiod Receptor agonists: 10α-Hydroxy TRK-820 derivatives
- … -[2-(1-pyrrolidinyl)-cyclohexyl] benzeneacetamide] Induces Internalization and Down-Regulation of the Human, but not the Rat, κ–opiod Receptor: Structural Basis for …
- Dynorphin regulates the phagocytic activity of splenic phagocytes in wall lizards: involvement of a κ–opiod Receptor-coupled adenylate-cyclase–cAMP–PKA pathway
- Nonspecific Effects of the Selective κ–opiod Receptor AgonistU-50,488 H on Dopamine Uptake and Release in PC12 Cells
- Mixed κ/μ opiod Receptor agonists: the 6β-naltrexamines
- Effects of R-84760, a selective κ–opiod Receptor agonist, on nociceptive reflex in isolated neonatal rat spinal cord
- Enantiomerically Pure Quinoline‐Based κ‐opiod Receptor Agonists: Chemoenzymatic Synthesis and Pharmacological Evaluation
- … Acid Conjugates of 2-(3,4-Dichlorophenyl)-N-methyl-N- [(1S)-1-(3-aminophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: κ opiod Receptor Agonists with Limited …
- Synthesis and opiod Receptor affinity of morphinan and benzomorphan derivatives: mixed κ agonists and μ agonists/antagonists as potential pharmacotherapeutics …
- Inhibitory effect of spiradoline, a κ opiod Receptor agonist, on Ca2+ induced contraction and the intracellular Ca2+ concentration in porcine coronary artery
- Quantitative analysis of R-84760, a selective κ–opiod Receptor agonist, in plasma by liquid chromatography with electrospray ionization tandem mass spectrometry
- Differential effects of specific δ and κ opiod Receptor antagonists on the bidirectional dose-dependent effect of systemic naloxone in arthritic rats, an experimental …
- κ opiod Receptor-mediated depression of activity evoked in convergent dorsal horn cells by thermal and non-thermal noxious stimulation
- … Disorder With Reduced In Vivo Norepinephrine Transporter Availability in the Locus Coeruleus” and “Association of In Vivo κ–opiod Receptor Availability and the …
- Involvement of κ–opiod Receptor mechanisms in the calcitonin-induced potentiation of opiod effects at the hypothalamus-pituitary-adrenocortical axis
- The NOP Receptor involvement in both withdrawal-and CCk-8-induced contracture responses of guinea pig isolated ileum after acute activation of κ–opiod Receptor
- … , ∂-, and κ–opiod Receptors and Comparisons to the Neuropeptide [Tyr1]-Leu-enkephalin: Conformations, Noncovalent Amino Acid Binding Sites, Binding Energies, Electronic Factors, and Receptor …
- μ-, δ-, κ-and ϵ-opiod Receptor modulation of the hypothalamic-pituitary-adrenocortical (HPA) axis: subchronic tolerance studies of endogenous opiod peptides
- κ‐ and δ‐opiod Receptor functional activities are increased in the caudate putamen of cannabinoid CB1 Receptor knockout mice
- Solubilization and characterization of the κ–opiod Receptor type from guinea-pig cerebellum
- … Aerobic Oxidation of nor-Binaltorphimine (nor-BNI) Analogs without 4, 5-Epoxy Bridge Affords a More Selective Ligand for κ opiod Receptor than the Representative …
- A novel series of potent and selective agonists at the opiod κ–Receptor
- Modification of the binding of [3H] MK-801 to brain regions and spinal cord of rats treated chronically with U-50,488 H, a κ–opiod Receptor agonist
- Influence of temperature on the effects of μ-, δ-and κ–opiod Receptor agonists in the guinea-pig ileum myenteric plexus
- κ–opiod Receptor recognition sites are not modulated by local anaesthetics
- Comparative Analysis of Infarct Size Limiting Activity of κ–opiod Receptor Agonists in In Vivo Reperfused Heart
- Comparison of the in vitro efficacy of μ, δ, κ and ORL1 Receptor agonists and non-selective opiod agonists in dog brain membranes
- Induction of bladder sphincter dyssynergia by κ-2 opiod Receptor agonists in the female rat
- Species variation in effects of intrathecal κ–opiod Receptor agonist on morphine-induced itch and antinociception
- Lack of effect of κ–opiod Receptor agonism on long-term methamphetamine-induced neurotoxicity in rats
- Inhibitory effects of κ–opiod Receptor stimulation on ne-induced cardiac hypertrophy of the cultured myocardial cells
- [Biocytin13] Dynorphin A 1-13 Amide: A Potential Probe for the κ–opiod Receptor
- Antagonism of phosphoramidon-induced antinociception in mice by μ-but not κ–opiod Receptor blockers
- An examination of the cardiac actions of PD117, 302, a κ–opiod Receptor agonist
- The role of κ–opiod Receptor-induced autophagy in synaptic alterations
- κ and δ-opiod Receptor agonists differentially inhibit striatal dopamine and acetylcholine release
- Peptidomimetics of the κ–opiod Receptor. A hybrid MPCB/peptide ligand (MPCB-RRI) binds κ cloned Receptor with nanomolar affinity
- dextro-and levo-morphine attenuate opiod δ and κ Receptor agonist produced analgesia in μ-opiod Receptor knockout mice
- Mixed κ agonists and μ agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opiod Receptor binding affinity of N-substituted …
- Design and synthesis of 10-oxo derivative of N-cyclopropylmethyl (−)-6β-acetylthiodihydro-normorphine, a potentially κ-selective opiod Receptor ligand
- Serotonergic mechanisms involved in calcitonin potentiation of κ–opiod Receptor-mediated effects on adrenal secretion
- Role of κ–opiod Receptor agonist U-50,488 H in consummatory successive negative contrast
- Paradoxical locomotor activating effects of κ–opiod Receptor stimulation in the preweanling rat:: Role of the ventromedial thalamus and superior colliculus
- The Region in the μ opiod Receptor Conferring Selectivity for Sufentanil over the δ Receptor is Different from that over the κ Receptor
- KATP channels mediate the antihypertrophic effects afforded by κ–opiod Receptor stimulation in neonatal rat ventricular myocytes
- Structural analysis of κ‐opiod Receptor agonists
- Synthesis of [3H]DIPPA: A potent irreversible antagonist selective for the κ opiod Receptor
- Antiarrhythmic effect of κ–opiod on Cx43 in rat heart during mycardial ischemia and reperfusion via inhibiting β-adrenergic Receptor pathway
- Computational insights into different inhibition modes of the κ–opiod Receptor with antagonists LY2456302 and JDTic
- … and peripheral modification of 1-(pyrrolidin-1-ylmethyl)-2-[(6-chloro-3-oxo-indan)-formyl]-1, 2, 3, 4-tetrahydroisoquinolines as novel selective κ opiod Receptor …
- Effects of naloxone, morphine and κ–opiod Receptor agonists on hypoxia/hypoglycemia-induced reduction of 2-deoxyglucose uptake in hippocampal slices from U …
- … effect of [(±)-(2, 4, 6-cis)-4-chloro-6-(naphthalen-1-yl)-tetrahydro-2H-pyran-2-yl] methanol: participation of the NO/cGMP/KATP pathway and κ–opiod Receptor
- Modulation of κ–opiod Receptor mediated tolerance in the guinea-pig ileum by chronic co-administration of dihydropyridines
- The antinociceptive activity of κ-but not δ-opiod Receptor agonists is maintained in morphine-tolerant neuropathic rats
- Interaction of the adenosine A1 Receptor agonist N6-cyclopentyladenosine and κ–opiod Receptors in rat spinal cord nociceptive reflexes
- Amphetamine-induced preprodynorphin mRNA expression and κ–opiod Receptor binding in basal ganglia of adult rats after prenatal exposure to diazepam
- Selective depression of dorsal root-evoked high threshold synaptic excitation by the selective κ opiod Receptor agonist enadoline in the neonatal rat hemisected …
- Spinal synthesis of estrogen and concomitant signaling by membrane estrogen Receptors regulate spinal κ-and μ-opiod Receptor heterodimerization and female …
- The opiod Receptor subtypes μ and κ, but not δ, are involved in the control of the vasopressin and oxytocin release in the rat
- Comparison of the Effects of a Series of κ–opiod Receptor Agonists Upon Sodium Channel Function in Rat Brain Miniprisms
- opiod antagonists and drinking: evidence of κ–Receptor involvement
- Developmental expression of the μ, κ, and δ opiod Receptor mRNAs in mouse
- δ antagonist and κ agonist activity of naltriben: Evidence for differential κ interaction with the δ1 and δ2 opiod Receptor subtypes
- κ–opiod Receptor is involved in electroacupuncture analgesia via inhibition of spinal microglial Toll-like Receptor 4 in neuropathic pain rats
- Angiotensin II induced myocardial hypertrophy in neonatal rats could be attenuated by activated κ–opiod Receptor via modulating the calcineurin signal pathways
- Enhancement of a κ–opiod Receptor agonist-induced analgesia by L-tyrosine and L-tryptophan
- Effects of the κ‑opiod Receptor on the inhibition of 100 Hz electroacupuncture on cocaine‑induced conditioned place preference
- Stereoselective Synthesis and Pharmacological Evaluation of 2, 4-Bridged Piperidine Derivatives Designed to Activate the κ–opiod Receptor
- Conversion of δ-, κ-and μ-Receptor Selective opiod Peptide Agonists into δ-, κ-and μ-Selective Antagonists
- Discovery of an opiod κ Receptor selective pure antagonist from a library of N-substituted 4β-methyl-5-(3-hydroxyphenyl) morphans
- Identification of the First trans-(3R,4R)- Dimethyl-4-(3-hydroxyphenyl)piperidine Derivative To Possess Highly Potent and Selective opiod κ Receptor Antagonist …
- opiod μ-and κ–Receptor mediate phospholipase C activation through Gi1 in Xenopus oocytes
- Synthesis and opiod Receptor binding affinities of 2-substituted and 3-aminomorphinans: Ligands for μ, κ, and δ opiod Receptors
- A DFT Analysis of the Relationships between Electronic Structure and Human κ, δ and μ opiod Receptor Binding Affinity in a series of Diphenethylamines
- The opiod Receptor like-1 Receptor agonist Ro 64-6198 (1S, 3aS-8-2, 3, 3a, 4, 5, 6-hexahydro-1H-phenalen-1-yl-1-phenyl-1, 3, 8-triaza-spiro [4.5] decan-4-one) …
- Synthesis and Characterisation of 𝜅 opiod Receptor (KOR) Antagonists
- Antipruritic Activity of a Novel κ–opiod Receptor Agonist
- … S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a Novel Potent and Selective opiod κ Receptor …
- Novel κ–opiod Receptor Antagonists Derived from Salvinorin A
- Remifentanil post‐conditioning attenuates cardiac ischemia–reperfusion injury via κ or δ opiod Receptor activation
- Cloning and pharmacological characterization of a rat κ opiod Receptor
- Essential structure of opiod κ Receptor agonist nalfurafine for binding to κ Receptor 1: synthesis of decahydroisoquinoline derivatives and their pharmacologies
- STUDY OF κ–opiod Receptor EXPRESSION IN CELL CULTURES AND IN HUMAN BRAIN
- κ‐opiod Receptor Activation Induces the Autophagic Machinery and Alters Dendritic Spine Density
- The efficacy of Dynorphin fragments at the κ, μ and δ opiod Receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation
- Studies of μ-, κ-, and δ-opiod Receptor density and G protein activation in the cortex and thalamus of monkeys
- Effect of Niravoline (RU51599), a κ–opiod Receptor Agonist, on Tumour-Origin Brain Oedema
- Role of activation of κ–opiod Receptor in inhibiting myocardial ischemia reperfusion injury in mice
- Inhibition of Human CaV2. 3 Channels via μ-, δ-and κ–opiod Receptor Activation
- Chemical neuroanatomical and psychopharmacological evidence that κ Receptor-mediated endogenous opiod peptide neurotransmission in the dorsal and …
- New thoughts in mechanism research of acupuncture for myocardial stunning from κ–opiod Receptor signaling pathway
- κ–opiod Receptor signals through Src and focal adhesion kinase to
- It takes more than one κ opiod Receptor to inhibit a POMC neuron
- Prospects for a Novel κ–opiod Receptor Agonist, TRK-820
- Do activators of the κ–opiod Receptor hold the potential for anti-arrhythmic drug development?
- Differential modulation of κ and μ opiod antinociception by the glycine/NMDA Receptor agonist D‐serine
- Differential inhibitory/stimulatory modulation of spinal CCK release by μ and δ opiod agonists, and selective blockade of μ-dependent inhibition by κ Receptor …
- Modulation of Renal Excretory Function by the Conformationally Restricted Enantiomeric κ‐opiod Receptor Agonists:(+) U‐50,488 and (−) U‐50,488
- Efficacy of acting κ opiod Receptor for prevention of high altitude pulmonary edema in rats
- Selective interference of β-arrestin 1 with κ and δ but not μ opiod Receptor/G protein coupling
- Discovery and biological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opiod Receptor agonist
- Stilbenes as κ-selective, non-nitrogenous opiod Receptor antagonists
- κ–opiod Receptor activation promotes mitochondrial fusion and enhances myocardial resistance to ischemia and reperfusion injury via STAT3-OPA1 pathway
- In silico results of κ–opiod Receptor antagonists as ligands for the second bromodomain of the Pleckstrin Homology Domain Interacting Protein
- Study on mechanisms of κ–opiod Receptor agonist affects neonatal rat myocardial hypertrophy induced by isoproterenol
- Structure of a κ–opiod Receptor misfit:(1S, 5R, 8R, 9R)-2′-hydroxy-5, 9-dimethyl-8, 2-epoxyethano-6, 7-benzomorphan hydrochloride
- The κ–opiod Receptor antagonist nor-binaltorphimine (nor-BNI) facilitates the development of morphine-induced behavioral sensitization
- Role of the Activation of Spinal κ–opiod Receptor in the Development of Spinal Centralization Induced by Remifentanil After Incision in Rats
- The Effects of κ–opiod Receptor Stimulation on Electrical Coupling during Ischemia in the Perfused Isolated Rat Heart
- 2P078 Interactions between Dynorpin and Extra Celler Loop II of κ–opiod Receptor as studied by Solid State NMR (30. Protein function (II), Poster Session, Abstract …
- Protective effect of κ–opiod Receptor agonist U50, 488 H pretreatment by intrathecal injection on myocardial ischemia/reperfusion injury
- The Widely Available Hallucinogenic Plant Salvia divinorum and Its Main Component, Salvinorin A: A Unique κ–opiod Receptor (KOP-r) Agonist with Powerful …
- Chronic U50, 488H abolishes inositol 1, 4, 5-trisphosphate and intracellular Ca 2+ elevations evoked by κ–opiod Receptor in rat myocytes
- Chronic Stress and Extended Access to Cocaine Produce Increased Drug Intake: Involvement of κ–opiod Receptor Activation
- Down-regulation of Spinal κ–opiod Receptor Involved in Spinal Centralization Induced by Remifentanil After Incision in Rats
- Agonists Specific for κ–opiod Receptor Induces Apoptosis of HCC Cells Through Enhanced Endoplasmic Reticulum Stress
- κ opiod Receptor Stimulation of [35S] GTPγS Binding in Guinea Pig Brain – Interaction with multiple G-proteins is not specific for any individual Gα subunit and is …
- Genome Mining-Based Discovery of Blenny Fish-Derived Peptides Targeting the Mouse κ–opiod Receptor
- β-adrenergic response modulated by κ–opiod Receptor stimulation is attenuated in the cardiomyocytes of rats following chronic hypoxia
- 1P103 Interaction of ECL-II of κ–opiod Receptor with dynorphin in membrane environments as revealed by solid state NMR, QCM and MD simulation (03. Membrane …
- Correction: In the article “κ–opiod Receptor Agonists Modulate Visceral Nociception at a Novel, Peripheral Site of Action,” by SK Joshi, Xin Su, Frank Porreca, and GF …
- 3P-174 Interaction of opiod peptide dynorphin with extracellular loop 2 of κ–opiod Receptor as studied by^< 13> C NMR (Biol & Artifi memb.: Structure & Property, The …
- … and ethanol concentrations in the nucleus accumbens during the development of reinforcement and the involvement of the κ–opiod Receptor in the modulation …
- Novel 3, 4, 7-Substituted Benzofuran Derivatives Having Binding Affinity to κ–opiod Receptor
- DIPPA: An opiod Receptor affinity label that produces selective and long-lasting κ antagonism in mice
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