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- SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages
- Sirt 1 activator inhibits the AGE-induced apoptosis and p53 acetylation in human vascular endothelial cells
- Cardiovascular effects of a novel SIRT 1 activator, SRT 2104, in otherwise healthy cigarette smokers
- The SIRT1 activator resveratrol protects SK‐N‐BE cells from oxidative stress and against toxicity caused by α‐synuclein or amyloid‐β (1‐42) peptide
- Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase
- Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1/FOXO3a-mediated autophagy and mitochondrial biogenesis
- SIRT 1‐mediated epigenetic downregulation of plasminogen activator inhibitor‐1 prevents vascular endothelial replicative senescence
- PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
- Treadmill exercise decreases amyloid-β burden possibly via activation of SIRT-1 signaling in a mouse model of Alzheimer’s disease
- Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity
- A novel biological role of α‐mangostin in modulating inflammatory response through the activation of SIRT‐1 signaling pathway
- Two novel SIRT1 activators, SCIC2 and SCIC2. 1, enhance SIRT1-mediated effects in stress response and senescence
- Peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial …
- SIRT1/PGC-1 pathway activation triggers autophagy/mitophagy and attenuates oxidative damage in intestinal epithelial cells
- Probing the mechanism of SIRT1 activation by a 1, 4-dihydropyridine
- Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway
- Involvement of TACE in colon inflammation: a novel mechanism of regulation via SIRT-1 activation
- Nutraceutical activators of AMPK/Sirt1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection
- Pharmacokinetics and tolerability of SRT 2104, a first‐in‐class small molecule activator of SIRT 1, after single and repeated oral administration in man
- Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice
- PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis
- SIRT1 silencing confers neuroprotection through IGF‐1 pathway activation
- Induction of autophagy and activation of SIRT‐1 deacetylation mechanisms mediate neuroprotection by the pomegranate metabolite urolithin A in BV2 microglia and …
- SirT1 activator represses the transcription of TNF‑α in THP‑1 cells of a sepsis model via deacetylation of H4K16
- Parthenolide Phytosomes Attenuated Gentamicin-Induced Nephrotoxicity in Rats via Activation of Sirt-1, Nrf2, OH-1, and NQO1 Axis
- SIRT 1 activator loaded inhaled antiangiogenic liposomal formulation development for pulmonary hypertension
- Oligo-fucoidan improves diabetes-induced renal fibrosis via activation of sirt-1, glp-1r, and nrf2/ho-1: An in vitro and in vivo study
- Inhibition of SIRT1 by HIV-1 viral protein Tat results in activation of p53 pathway
- α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase
- Sirt 1 activator attenuates the bleomycin-induced lung fibrosis in mice via inhibiting epithelial-to-mesenchymal transition (EMT).
- Homocysteine facilitates LOX-1 activation and endothelial death through the PKCβ and SIRT1/HSF1 mechanism: relevance to human hyperhomocysteinaemia
- … Effect of DiDang Tang Against AlCl3-Induced Oxidative Stress and Apoptosis in PC12 Cells Through the Activation of SIRT1-Mediated Akt/Nrf2/HO-1 …
- AMPK inhibits MTDH expression via GSK 3β and SIRT 1 activation: potential role in triple negative breast cancer cell proliferation
- Occludin controls HIV transcription in brain pericytes via regulation of SIRT-1 activation
- A pharmacological review on SIRT 1 and SIRT 2 proteins, activators, and inhibitors: Call for further research
- … dysfunction by cantleyoside confines inflammatory response and promotes apoptosis of human HFLS-RA cell line via AMPK/Sirt 1/NF-κB pathway activation
- Low-frequency electroacupuncture improves insulin sensitivity in obese diabetic mice through activation of SIRT1/PGC-1 in skeletal muscle
- Activating SIRT-1 Signalling with the Mitochondrial-CoQ10 Activator Solanesol Improves Neurobehavioral and Neurochemical Defects in Ouabain-Induced …
- Endothelial LOX-1 activation differentially regulates arterial thrombus formation depending on oxLDL levels: role of the Oct-1/SIRT1 and ERK1/2 pathways
- Activation of SIRT-1 Signalling in the Prevention of Bipolar Disorder and Related Neurocomplications: Target Activators and Influences on Neurological Dysfunctions
- Thymoquinone ameliorates diabetic phenotype in Diet-Induced Obesity mice via activation of SIRT-1-dependent pathways
- N1-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation
- Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-κB ligand (RANKL) activation of NF-κB signaling and inhibit …
- Resveratrol inhibits the hydrogen dioxide-induced apoptosis via Sirt 1 activation in osteoblast cells
- … IIA sulfonate protects against hyperhomocysteine-induced vascular endothelial injury via activation of NNMT/SIRT1-mediated NRF2/HO-1 and AKT/MAPKs …
- … ischemia–reperfusion injury by reducing oxidative stress and endoplasmic reticulum stress-mediated apoptosis in type 1 diabetic rats: role of SIRT1 activation
- Aloin reduces HMGB1-mediated septic responses and improves survival in septic mice by activation of the SIRT1 and PI3K/Nrf2/HO-1 signaling axis
- … ethanolic extract attenuates chronic restraint stress aggravated DSS-induced ulcerative colitis in mice via inhibition of NF-κB/STAT3 and activation of HO-1/Nrf2/SIRT1 …
- Activation of AMPK-dependent SIRT-1 by astragalus polysaccharide protects against ochratoxin A-induced immune stress in vitro and in vivo
- … confers neuroprotection against hypoxia-ischemia induced brain damage in neonatal rats via autophagy and silent information regulator 1 (SIRT1) activation
- Tetrandrine alleviates cerebral ischemia/reperfusion injury by suppressing NLRP3 inflammasome activation via Sirt-1
- … M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1
- 1, 25-Dihydroxyvitamin D decreases tertiary butyl-hydrogen peroxide-induced oxidative stress and increases AMPK/SIRT1 activation in C2C12 muscle cells
- Grape seed proanthocyanidins prevent H2O2‐induced mitochondrial dysfunction and apoptosis via SIRT 1 activation in embryonic kidney cells
- Activation of SIRT-1 Pathway by Nanoceria Sheds Light on Its Ameliorative Effect on Doxorubicin-Induced Cognitive Impairment (Chemobrain): Restraining Its …
- SIRT1 protects against aortic dissection by regulating AP-1/decorin signaling-mediated PDCD4 activation
- … the expression of adiponectin in 3T3-L1 adipocytes via the activation of silent mating type information regulation 2 homologue 1 (SIRT1)-deacetylase and peroxisome …
- Avasimibe and Sirt 1 Activators Reverse NAFLD and Obesity.
- … sulfate promotes arterial thrombosis in rat model via increased levels of complex TF/VII, PAI-1, platelet activation as well as decreased contents of SIRT1 and …
- Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation
- Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway
- … inhibits hypoxia‐inducible factor‐1 alpha and carbonic anhydrase expression through activation of AMP‐activated protein kinase/HO‐1/Sirt1 pathway in glioblastoma …
- Dysregulation of SIRT-1 signaling in multiple sclerosis and neuroimmune disorders: a systematic review of sirtuin activators as potential immunomodulators and their …
- Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators
- A series of novel indazole derivatives of Sirt 1 activator as osteogenic regulators
- Fucoidan inhibits apoptosis and improves cardiac remodeling by inhibiting p53 transcriptional activation through USP22/Sirt 1
- … Mellitus by Activating Monophosphate-Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Axis and Inhibiting Nuclear Factor-kappa B (NF-κB) Activation
- … acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colon …
- Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1
- SIRT-1 ACTIVATORS–IN DIABETIC NEPHROPATHY
- Amelioration of high-fat diet (HFD)+ CCl4 induced NASH/NAFLD in CF-1 mice by activation of SIRT-1 using cinnamoyl sulfonamide hydroxamate derivatives …
- Activation of the cannabinoid receptor 1 by ACEA suppresses senescence in human primary chondrocytes through sirt1 activation
- HIC2, a new transcription activator of SIRT1
- Synthesis of four SIRT1 activators based on an imidazo [1, 2-b] thiazole structure, in vitro derived metabolites and deuterated analogs
- Integrated ligand and structure-based investigation of structural requirements for silent information regulator 1 (SIRT1) activation
- Solanesol Mediated SIRT-1 Activation Prevents Neurobehavioral and Neurochemical Defects in Ouabain-Induced Experimental Model of Bipolar Disorder in Rats
- Solanesol Mediated SIRT-1 Signaling Activation Prevents Neurobehavioral and Neurochemical Defects in Ouabain-induced Experimental Model of Bipolar Disorder …
- Activation of Sirtuin 1 (SIRT1) Signaling by Resveratrol Increases Human Beta‐Defensins‐2 and‐3 (HBD2, HBD3) Production in Response to Lipopolysaccharide …
- Silent Information Regulator 1 (SIRT1) Promotes Pancreatic β-Cell Mitochondrial Autophagy and Pyrin Domains-Containing Protein 3 (NLRP3) Activation Under High …
- Identification and molecular modeling of novel endogenous activator proteins of Sirt-1: an in silico study.
- SIRT-1 ACTIVATOR RESVERATROL PROTECTS HUVECs FROM HIGH GLUCOSE-DEPENDENT REDOX AND GLYCATIVE IMBALANCES
- INVESTIGATION OF SIRT-1 ACTIVATOR IN INTRACEREBROPEDUNCLE ETHIDIUM BROMIDE INDUCED EXPERIMENTAL MODEL OF MULTIPLE SCLEROSIS IN …
- Cardiovascular Effects of a Novel SIRT 1 Activator, SRT2104, in Otherwise Healthy Cigarette Smokers
- Cardiovascular effects of the treatments for diabetes mellitus: the effect of SIRT-1 activation on markers of endothelial function, arterial stiffness and thrombosis; and …
- … OF NOVEL 4-THIAZOLIDINONE DERIVATIVES BEARING 1, 3, 4-OXADIAZOLE MOIETY AS SIRT-3 ACTIVATORS TARGETING PARKINSON’S DISEASE
- SirT1 blocks apoptosis in human chondrocytes via activation of the IGF-1 Receptor/Akt pathway
- GW25-e1524 SIRT1-Mediated Epigenetic Downregulation of Plasminogen Activator Inhibitor-1 Prevents Vascular Endothelial Replicative Senescence
- Ligand docking suggests isomer specific catechin induced SIRT‐1 activation
- … modeling, Molecular Dynamic Simulation and in silico screening of Activator for the Intensification of human sirtuin type 1 (SIRT1) by novel 1, 3, 4-thiadiazole …
- Treadmill exercise upregulates the non-amyloidogenic pathway and inhibits amyloid-b production via activation of SIRT-1 signaling in a mouse model of Alzheimer’s …
- Activation of a class-III histone deacetylase, SIRT1, prevents the oxidative-stress mediated cell-death by suppressing the activity of poly (ADP) ribose polymerase-1
- Sirt-1 Induces Vascular Endothelial Growth Factor Through The Activation of HIF-2α In Hypoxia
- Endothelial LOX-1 Protects Against Arterial Thrombosis via Activation of the Oct-1/SIRT1 Pathway
- Hsp90 inhibition suppresses NF-kB transcriptional activation via Sirt-2 in human 1 lung microvascular endothelial cells. 2
- Activation of the AKT Pathway Mediates Upregulation of Hif-1α and Sirt1 via Downregulation of miR-199a and is Neutralized by Beta-adrenergic Stimulation
- Paeonol attenuates high glucose-induced expression of FN and ICAM-1 by promoting the activation of Nrf2/ARE pathway via upregulation of Sirt1 in GMCs
- Synthesis and Yeast-based Screening of 1, 3-benzodioxole Derivatives for SIRT1 Activators
