SIRTUINS AND LONGEVITY

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  1. Sirtuin functions in health and disease
  2. Sirtuin chemical mechanisms
  3. Sirtuin activators
  4. From sirtuin biology to human diseases: an update
  5. Sirtuin activators and inhibitors
  6. Sirtuin catalysis and regulation
  7. Biological and potential therapeutic roles of sirtuin deacetylases
  8. Structural basis for sirtuin function: what we know and what we don’t
  9. Sirtuin deacetylases in neurodegenerative diseases of aging
  10. The Sirtuin family: therapeutic targets to treat diseases of aging
  11. Sirtuin inhibitors
  12. Sirtuin 1 in lipid metabolism and obesity
  13. Sirtuin regulation in aging and injury
  14. A molecular mechanism for direct sirtuin activation by resveratrol
  15. Sirtuin 1 and sirtuin 3: physiological modulators of metabolism
  16. The sirtuin family’s role in aging and age-associated pathologies
  17. Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation
  18. Emerging role of sirtuin 2 in the regulation of mammalian metabolism
  19. SIRTUIN 1: regulating the regulator
  20. Sirtuin activators mimic caloric restriction and delay ageing in metazoans
  21. Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling
  22. Sirtuin deacylases: a molecular link between metabolism and immunity
  23. Sirtuin-1 regulation of mammalian metabolism
  24. Sirtuin and metabolic kidney disease
  25. Structural basis for sirtuin activity and inhibition
  26. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1
  27. Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect
  28. Redox Regulation of Sirtuin-1 by S-Glutathiolation
  29. Sirtuin inhibitors as anticancer agents
  30. Sirtuin 6: a review of biological effects and potential therapeutic properties
  31. The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations
  32. Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
  33. Altered sirtuin expression is associated with node-positive breast cancer
  34. The sirtuin SIRT6 regulates lifespan in male mice
  35. Sirtuin 1 in malignant transformation: friend or foe?
  36. Involvement of mammalian sirtuin 1 in the action of ethanol in the liver
  37. Regulation of sirtuin function by posttranslational modifications
  38. Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity
  39. Sirtuin-1 and HIV-1: an overview
  40. The human sirtuin family: evolutionary divergences and functions
  41. Targeting sirtuin 1 to improve metabolism: all you need is NAD+?
  42. The diversity of histone versus nonhistone sirtuin substrates
  43. A novel continuous assay for the deacylase sirtuin 5 and other deacetylases
  44. Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease
  45. The life span-prolonging effect of sirtuin-1 is mediated by autophagy
  46. Sirtuin 1 regulation of developmental genes during differentiation of stem cells
  47. Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson’s disease
  48. Sirtuin 3–dependent mitochondrial dynamic improvements protect against acute kidney injury
  49. Sirtuin 1: a target for kidney diseases
  50. Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1α
  51. Proteolipid protein is required for transport of sirtuin 2 into CNS myelin
  52. Sirtuin 1 in immune regulation and autoimmunity
  53. Renal protective effect of sirtuin 1
  54. Role of Sirtuin 1 in metabolic regulation
  55. Neuroprotective Sirtuin ratio reversed by ApoE4
  56. Vitamin B3 and sirtuin function
  57. The Structural Basis of Sirtuin Substrate Affinity,
  58. Sirtuin-7 inhibits the activity of hypoxia-inducible factors
  59. Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases
  60. Sirtuin 1 (SIRT1) the misunderstood HDAC
  61. Oxidative stress, glutathione status, sirtuin and cellular stress response in type 2 diabetes
  62. The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension
  63. The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability
  64. Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells
  65. Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity
  66. Structure-based development of novel sirtuin inhibitors
  67. Sirtuin 3, a new target of PGC-1α, plays an important role in the suppression of ROS and mitochondrial biogenesis
  68. Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner
  69. Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer
  70. Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
  71. Aging genes: the sirtuin story unravels
  72. Mechanism of sirtuin inhibition by nicotinamide: altering the NAD+ cosubstrate specificity of a Sir2 enzyme
  73. Sirtuin‐3 (SIRT3), a novel potential therapeutic target for oral cancer
  74. Sirtuin modulators: an updated patent review (2012–2014)
  75. Structure–activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode
  76. Sirtuin function in aging heart and vessels
  77. Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity
  78. Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins
  79. Distinct patterns of sirtuin expression during progression of Alzheimer’s disease
  80. Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms
  81. An in silico approach to discovering novel inhibitors of human sirtuin type 2
  82. Sirtuin functions in female fertility: possible role in oxidative stress and aging
  83. Sirtuin‐dependent epigenetic regulation in the maintenance of genome integrity
  84. Crosstalk between poly (ADP-ribose) polymerase and sirtuin enzymes
  85. The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington’s disease mouse models
  86. Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors
  87. A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 1.
  88. Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner
  89. MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae
  90. Sirtuin‐6–dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients
  91. Rapid temporal control of Foxp3 protein degradation by sirtuin-1
  92. Sirtuin 1 signaling and alcoholic fatty liver disease
  93. The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin
  94. Regulation of hypoxia-inducible factor 2α signaling by the stress-responsive deacetylase sirtuin 1
  95. Silent information regulator, Sirtuin 1, and age‐related diseases
  96. Sirtuin 6 protects the heart from hypoxic damage
  97. Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3
  98. Medicinal chemistry of sirtuin inhibitors
  99. The sirtuin system: the holy grail of resveratrol?
  100. Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis
  101. Differential expression of sirtuin family members in the developing, adult, and aged rat brain
  102. The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling
  103. Altered sirtuin deacetylase gene expression in patients with a mood disorder
  104. Identification of tri‐and tetracyclic pyrimidinediones as sirtuin inhibitors
  105. Downregulation of miR-199a derepresses hypoxia-inducible factor-1α and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes
  106. Sirtuin activators: designing molecules to extend life span
  107. The role of sirtuin proteins in obesity
  108. A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: Part 2.
  109. The sirtuin 3 expression profile is associated with pathological and clinical outcomes in colon cancer patients
  110. Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis
  111. Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans
  112. Sirtuin gene expression in human mononuclear cells is modulated by caloric restriction
  113. Sirtuin 7 in cell proliferation, stress and disease: Rise of the Seventh Sirtuin!
  114. Function and metabolism of sirtuin metabolite O-acetyl-ADP-ribose
  115. Sirtuin modulators
  116. Nicotinamide restores cognition in Alzheimer’s disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau
  117. Sirtuin 7 plays a role in ribosome biogenesis and protein synthesis
  118. Advances in characterization of human sirtuin isoforms: chemistries, targets and therapeutic applications
  119. The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases
  120. Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity
  121. Sirtuin-1 Targeting Promotes Foxp3+ T-Regulatory Cell Function and Prolongs Allograft Survival
  122. Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone
  123. Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients
  124. Sirtuin-1 is a nutrient-dependent modulator of inflammation
  125. Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients
  126. The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun
  127. Role of sirtuin histone deacetylase SIRT1 in prostate cancer: a target for prostate cancer management via its inhibition?
  128. Analysis of sirtuin 1 expression reveals a molecular explanation of IL-2–mediated reversal of T-cell tolerance
  129. SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes
  130. Sirtuin-dependent clock control: new advances in metabolism, aging and cancer
  131. Sirtuin modulators control reactive gliosis in an in vitro model of Alzheimer’s disease
  132. Sirtuin 6 expression and inflammatory activity in diabetic atherosclerotic plaques: effects of incretin treatment
  133. Plasmodium falciparum Sir2: an Unusual Sirtuin with Dual Histone Deacetylase and ADP-Ribosyltransferase Activity
  134. Resveratrol induces a mitochondrial complex I-dependent increase in NADH oxidation responsible for sirtuin activation in liver cells
  135. Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth
  136. The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS
  137. Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production
  138. Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1–uncoupling protein 2 pathway
  139. Sirtuin 1 and aging theory for chronic obstructive pulmonary disease
  140. Sirtuin 3 mediates neuroprotection of ketones against ischemic stroke
  141. The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5)
  142. Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease
  143. Long-term physical exercise induces changes in sirtuin 1 pathway and oxidative parameters in adult rat tissues
  144. Sirtuin-3 (SIRT3) and the Hallmarks of Cancer
  145. Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/− Mice: A Role of Lipid Mobilization and Inflammation
  146. Anti‐aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway
  147. Insights into the sirtuin mechanism from ternary complexes containing NAD+ and acetylated peptide
  148. Sirtuin 1 gene polymorphisms are associated with body fat and blood pressure in Japanese
  149. Sirtuin deacetylases: a new target for melanoma management
  150. Sirtuin biology and relevance to diabetes treatment
  151. Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria
  152. Inhibition of the human deacylase Sirtuin 5 by the indole GW5074
  153. New assays and approaches for discovery and design of Sirtuin modulators
  154. Sirtuin‐independent effects of nicotinamide on lifespan extension from calorie restriction in yeast
  155. Substrates for efficient fluorometric screening employing the NAD-dependent sirtuin 5 lysine deacylase (KDAC) enzyme
  156. NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response
  157. Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection
  158. A nuclear-localized fluorescent hydrogen peroxide probe for monitoring sirtuin-mediated oxidative stress responses in vivo
  159. Overexpression of sirtuin 6 suppresses inflammatory responses and bone destruction in mice with collagen‐induced arthritis
  160. Thiobarbiturates as Sirtuin Inhibitors: Virtual Screening, Free‐energy calculations, and biological testing
  161. Cloning, chromosomal characterization and mapping of the NAD-dependent histone deacetylases gene sirtuin 1
  162. Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine
  163. Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors
  164. An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms
  165. Sirtuin 1 retards hyperphosphatemia-induced calcification of vascular smooth muscle cells
  166. The NAD‐dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation
  167. Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?
  168. A patent review of sirtuin activators: an update
  169. Kinetic and Structural Basis for Acyl-Group Selectivity and NAD+ Dependence in Sirtuin-Catalyzed Deacylation
  170. Sirtuin modulators: mechanisms and potential clinical implications
  171. Adenosine Mimetics as Inhibitors of NAD+-Dependent Histone Deacetylases, from Kinase to Sirtuin Inhibition
  172. A mini-review on Sirtuin activity assays
  173. Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells
  174. Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity
  175. A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase
  176. NAMPT is essential for the G-CSF–induced myeloid differentiation via a NAD+–sirtuin-1–dependent pathway
  177. Sirtuin regulation in calorie restriction
  178. Function and regulation of the mitochondrial Sirtuin isoform Sirt5 in Mammalia
  179. The role of sirtuin 1 in osteoblastic differentiation in human periodontal ligament cells
  180. Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model
  181. Sirtuin deacetylases as therapeutic targets in the nervous system
  182. A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington’s disease
  183. Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity
  184. The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson’s disease but not amyotrophic lateral sclerosis and cerebral ischemia
  185. A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer
  186. Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes
  187. Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-κB in macrophages in vitro and in rat lungs in vivo: implications for …
  188. Altered sirtuin 7 expression is associated with early stage breast cancer
  189. The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells
  190. Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia
  191. Non-sirtuin histone deacetylases in the control of cardiac aging
  192. Sirtuin 1 activator SRT 2104 protects Huntington’s disease mice
  193. The sirtuin class of histone deacetylases: regulation and roles in lipid metabolism
  194. Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through …
  195. Sirtuin 1–mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin
  196. Urea cycle regulation by mitochondrial sirtuin, SIRT5
  197. Peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis
  198. Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF‐κB‐dependent transcriptional activity
  199. Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity
  200. Sirtuin 1 (SIRT1) and steroid hormone receptor activity in cancer
  201. Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence
  202. Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep‐deprived rats
  203. Genome-wide analysis of functional sirtuin chromatin targets in yeast
  204. Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1
  205. Sirtuin 1 attenuates oxidative stress via upregulation of superoxide dismutase 2 and catalase in astrocytes
  206. A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition
  207. Potential role of sirtuin as a therapeutic target for neurodegenerative diseases
  208. Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin‐induced mouse model of asthma
  209. Involvement of sirtuin 1 in airway inflammation and hyperresponsiveness of allergic airway disease
  210. Mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studies
  211. The Arabidopsis class II sirtuin is a lysine deacetylase and interacts with mitochondrial energy metabolism
  212. Sirtuin 1 regulates hepatitis B virus transcription and replication by targeting transcription factor AP-1
  213. Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection
  214. Fungus-specific sirtuin HstD coordinates secondary metabolism and development through control of LaeA
  215. Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development
  216. Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site
  217. Catalysis and mechanistic insights on Sirtuin activation
  218. Molecular pathways: emerging roles of mammalian Sirtuin SIRT7 in cancer
  219. Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells
  220. The protein–protein interaction network of the human Sirtuin family
  221. Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing
  222. A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress
  223. Zinc neurotoxicity is dependent on intracellular NAD+ levels and the sirtuin pathway
  224. Constitutive nuclear localization of an alternatively spliced sirtuin-2 isoform
  225. Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target
  226. Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells
  227. Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 …
  228. Identification of inhibitor binding site in human sirtuin 2 using molecular docking and dynamics simulations
  229. Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension
  230. SIRTUIN 1 gene polymorphisms are associated with cholesterol metabolism and coronary artery calcification in Japanese hemodialysis patients
  231. The contentious history of sirtuin debates
  232. Identification and characterization of novel sirtuin inhibitor scaffolds
  233. Sirtuin inhibition induces apoptosis-like changes in platelets and thrombocytopenia
  234. Hydrolase controls cellular NAD, sirtuin, and secondary metabolites
  235. Sirtuin 1 deacetylase: a key regulator of hepatic lipid metabolism
  236. Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene
  237. Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction
  238. Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence
  239. SIRT7 an emerging sirtuin: deciphering newer roles
  240. Sirtuin-4 (SIRT4) is downregulated and associated with some clinicopathological features in gastric adenocarcinoma
  241. Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach
  242. Plant defence suppression is mediated by a fungal sirtuin during rice infection by Magnaporthe oryzae
  243. Therapeutic potential of sirtuin-activating compounds in Alzheimer’s disease.
  244. α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase
  245. Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1)
  246. Association of the sirtuin and mitochondrial uncoupling protein genes with carotid plaque
  247. Epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors
  248. Ca2+/calmodulin-dependent protein kinase kinase β phosphorylation of Sirtuin 1 in endothelium is atheroprotective
  249. Sirtuin 1-mediated inhibition of p66shc expression alleviates liver ischemia/reperfusion injury
  250. Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor
  251. Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia
  252. Biochemical characterization of sirtuin 6 in the brain and its involvement in oxidative stress response
  253. Novel thiourea-based sirtuin inhibitory warheads
  254. Endothelial sirtuin 1 deficiency perpetrates nephrosclerosis through downregulation of matrix metalloproteinase-14: relevance to fibrosis of vascular senescence
  255. Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells
  256. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi
  257. Free [NADH]/[NAD+] regulates sirtuin expression
  258. Ginsenoside Rb1 Prevents H2O2-Induced HUVEC Senescence by Stimulating Sirtuin-1 Pathway
  259. Ubiquitinated sirtuin 1 (SIRT1) function is modulated during DNA damage-induced cell death and survival
  260. Sirtuin 7 promotes cellular survival following genomic stress by attenuation of DNA damage, SAPK activation and p53 response
  261. Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity
  262. Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide‐based inhibitors
  263. Vascular Smooth Muscle Sirtuin‐1 Protects Against Aortic Dissection During Angiotensin II–Induced Hypertension
  264. Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin
  265. Molecular cloning and characterization of porcine sirtuin genes.
  266. Sirtuin-3 (SIRT3) protein attenuates doxorubicin-induced oxidative stress and improves mitochondrial respiration in H9c2 cardiomyocytes
  267. trans-(−)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington …
  268. Mechanical stress‐activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells
  269. Functional Analysis of Sirtuin Genes in Multiple Plasmodium falciparum Strains
  270. Sirtuin 1 activation enhances the PGC-1α/mitochondrial antioxidant system pathway in status epilepticus
  271. Sirtuin 1 participates in the process of age-related retinal degeneration
  272. Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1
  273. Disruption of sirtuin 1–mediated control of circadian molecular clock and inflammation in chronic obstructive pulmonary disease
  274. Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice
  275. Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3
  276. A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation
  277. Sirtuin inhibition attenuates the production of inflammatory cytokines in lipopolysaccharide-stimulated macrophages
  278. Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D
  279. Regulation of histone H2A. Z expression is mediated by sirtuin 1 in prostate cancer
  280. Selectivity hot-spots of sirtuin catalytic cores
  281. Synergistic effects of polyphenols and methylxanthines with Leucine on AMPK/Sirtuin-mediated metabolism in muscle cells and adipocytes
  282. Melatonin reduces endoplasmic reticulum stress and preserves sirtuin 1 expression in neuronal cells of newborn rats after hypoxia–ischemia
  283. The Sirtuin Inhibitor Nicotinamide Enhances Neuronal Cell Survival During Acute Anoxic Injury Through AKT, BAD, PARP, and Mitochondrial Associated
  284. Metformin ameliorates the proinflammatory state in patients with carotid artery atherosclerosis through sirtuin 1 induction
  285. Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence
  286. The E. coli sirtuin CobB shows no preference for enzymatic and nonenzymatic lysine acetylation substrate sites
  287. Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3
  288. Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1
  289. Environmental enrichment lessens cognitive decline in APP23 mice without affecting brain sirtuin expression
  290. Sirtuin-3 (SIRT3) expression is associated with overall survival in esophageal cancer
  291. Sirtuin 6 Is Essential for Sodium Sulfide-mediated Cytoprotective Effect in Ischemia/Reperfusion–Stimulated Brain Endothelial Cells
  292. Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities
  293. Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients
  294. Discovering inhibitors of human sirtuin type 2: novel structural scaffolds
  295. Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner
  296. Cyclic AMP mimics the anti-ageing effects of calorie restriction by up-regulating sirtuin
  297. Resveratrol improves the quality of pig oocytes derived from early antral follicles through sirtuin 1 activation
  298. Hepatoprotection of Berberine Against Hydrogen Peroxide‐induced Apoptosis by Upregulation of Sirtuin 1
  299. A proteomic perspective of Sirtuin 6 (SIRT6) phosphorylation and interactions and their dependence on its catalytic activity
  300. Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression
  301. The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock
  302. Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells
  303. Association between Sirtuin 2 gene rs10410544 polymorphism and depression in Alzheimer’s disease in two independent European samples
  304. The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling
  305. Sirtuin 3 interacts with Lon protease and regulates its acetylation status
  306. Sirtuin and pan-class I/II deacetylase (DAC) inhibition is synergistic in preclinical models and clinical studies of lymphoma
  307. Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation
  308. Sirtuin 1 modulation in rat model of acetaminophen-induced hepatotoxicity
  309. Neurons from senescence‐accelerated SAMP8 mice are protected against frailty by the sirtuin 1 promoting agents melatonin and resveratrol
  310. The class III histone deacetylase sirtuin 1 in immune suppression and its therapeutic potential in rheumatoid arthritis
  311. Regulation of cerebral vascular function by sirtuin 1
  312. Sirtuin 1 regulates dendritic cell activation and autophagy during respiratory syncytial virus–induced immune responses
  313. Fluorescence in situ hybridization and chromosomal organization of the human Sirtuin 7 gene
  314. Sirtuin family: a link to metabolic signaling and senescence
  315. SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183
  316. A novel crosstalk between BRCA1 and sirtuin 1 in ovarian cancer
  317. Sirtuin-6 inhibits cardiac fibroblasts differentiation into myofibroblasts via inactivation of nuclear factor κB signaling
  318. Apo-10′-Lycopenoic Acid, a Lycopene Metabolite, Increases Sirtuin 1 mRNA and Protein Levels and Decreases Hepatic Fat Accumulation in ob/ob Mice
  319. Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) …
  320. Evaluation of sirtuin role in neuroprotection of retinal ganglion cells in hypoxia
  321. Sirtuin 1 activation stimulates mitochondrial biogenesis and attenuates renal injury after ischemia-reperfusion
  322. Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation
  323. Expression patterns of sirtuin genes in porcine preimplantation embryos and effects of sirtuin inhibitors on in vitro embryonic development after parthenogenetic …
  324. Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D mediated by sirtuin-3
  325. Des-acyl ghrelin protects microvascular endothelial cells from oxidative stress-induced apoptosis through sirtuin 1 signaling pathway
  326. Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity
  327. Enhanced tolerance against early and late apoptotic oxidative stress in mammalian neurons through nicotinamidase and sirtuin mediated pathways
  328. Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3
  329. Sirtuin deacetylation mechanism and catalytic role of the dynamic cofactor binding loop
  330. The histone deacetylase sirtuin 1 is reduced in systemic sclerosis and abrogates fibrotic responses by targeting transforming growth factor β signaling
  331. Cold acclimation increases levels of some heat shock protein and sirtuin isoforms in threespine stickleback
  332. Sirtuin‐6 deficiency exacerbates diabetes‐induced impairment of wound healing
  333. Calorie restriction and NAD+/sirtuin counteract the hallmarks of aging
  334. Cross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation
  335. Benzimidazoles as new scaffold of sirtuin inhibitors: Green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties
  336. Sirtuin 1 facilitates generation of induced pluripotent stem cells from mouse embryonic fibroblasts through the miR-34a and p53 pathways
  337. Finding a sirtuin truth in Huntington’s disease
  338. Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2
  339. Targeting sirtuin-1 in Huntington’s disease: rationale and current status
  340. Sirtuin 1 regulates skeletal myoblast survival and enhances differentiation in the presence of resveratrol
  341. Sirtuin 1 promotes Th2 responses and airway allergy by repressing peroxisome proliferator-activated receptor-γ activity in dendritic cells
  342. Sirtuin mechanism and inhibition: explored with Nε-acetyl-lysine analogs
  343. Inhibition of sirtuin 2 with sulfobenzoic acid derivative AK1 is non-toxic and potentially neuroprotective in a mouse model of frontotemporal dementia
  344. Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1
  345. The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals
  346. Comparative modeling and benchmarking data sets for human histone deacetylases and sirtuin families
  347. Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice
  348. Nephroprotective action of sirtuin 1 (SIRT1)
  349. Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells
  350. The selective sirtuin 1 activator SRT2104 reduces endotoxin-induced cytokine release and coagulation activation in humans
  351. Superoxide mediates acute liver injury in irradiated mice lacking sirtuin 3
  352. Nicotinamide N-methyltransferase increases complex I activity in SH-SY5Y cells via sirtuin 3
  353. Light–dark condition regulates sirtuin mRNA levels in the retina
  354. Oxidative stress and ROS metabolism via down-regulation of sirtuin 3 expression in Cmah-null mice affect hearing loss
  355. miR-217 regulates ethanol-induced hepatic inflammation by disrupting sirtuin 1–Lipin-1 signaling
  356. Paeonol protects against premature senescence in endothelial cells by modulating Sirtuin 1 pathway
  357. Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge
  358. Insulin receptor A and Sirtuin 1 synergistically improve learning and spatial memory following chronic salidroside treatment during hypoxia
  359. In Bacillus subtilis, the Sirtuin Protein Deacetylase, Encoded by the srtN Gene (Formerly yhdZ), and Functions Encoded by the acuABC Genes Control the Activity of …
  360. Resveratrol suppresses inflammatory responses in endometrial stromal cells derived from endometriosis: a possible role of the sirtuin 1 pathway
  361. Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanism
  362. Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of sirtuin domain deacetylases by NAD metabolites
  363. Polyphenol-enriched cocoa protects the diabetic retina from glial reaction through the sirtuin pathway
  364. Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein
  365. Age-related decrease in the mitochondrial sirtuin deacetylase Sirt3 expression associated with ROS accumulation in the auditory cortex of the mimetic aging …
  366. Sirtuin-1 regulates acinar-to-ductal metaplasia and supports cancer cell viability in pancreatic cancer
  367. Identification of Sirtuin 3, a mitochondrial protein deacetylase, as a new contributor to tamoxifen resistance in breast cancer cells
  368. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6
  369. Sirolimus and everolimus induce endothelial cellular senescence via sirtuin 1 down-regulation: therapeutic implication of cilostazol after drug-eluting stent …
  370. Innovative cosmeceuticals: sirtuin activators and anti-glycation compounds
  371. Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer
  372. Sirtuin 1 functionally and physically interacts with disruptor of telomeric silencing-1 to regulate α-ENaC transcription in collecting duct
  373. Side chain specificity of ADP‐ribosylation by a sirtuin
  374. Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization
  375. Interrelationships between sirtuin 1 and transcription factors p53 and NF-κB (p50/p65) in the control of ovarian cell apoptosis and proliferation
  376. Blocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy
  377. Glucagon-like peptide 1 inhibits the sirtuin deacetylase SirT1 to stimulate pancreatic β-cell mass expansion
  378. A dual role for sirtuin 1 in tumorigenesis
  379. Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay
  380. Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/β-catenin activity
  381. Reciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: implications for aging and neurodegeneration
  382. Depletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells
  383. Protective effects of resveratrol against streptozotocin-induced diabetes in rats by modulation of visfatin/sirtuin-1 pathway and glucose transporters
  384. Effects of sirtuin 1 activation on nicotine and lipopolysaccharide‐induced cytotoxicity and inflammatory cytokine production in human gingival fibroblasts
  385. The anti-atherogenic effects of berberine on foam cell formation are mediated through the upregulation of sirtuin 1
  386. … induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling …
  387. Sirtuin-2 activity is required for glioma stem cell proliferation arrest but not necrosis induced by resveratrol
  388. Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: neuroprotective or neurotoxic properties of sirtuins in ALS?
  389. High-throughput assays for sirtuin enzymes: a microfluidic mobility shift assay and a bioluminescence assay
  390. Circulating levels of sirtuin 4, a potential marker of oxidative metabolism, related to coronary artery disease in obese patients suffering from NAFLD, with …
  391. Cross regulation of sirtuin 1, AMPK, and PPARγ in conjugated linoleic acid treated adipocytes
  392. Preliminary data on the relationship between circulating levels of Sirtuin 4, anthropometric and metabolic parameters in obese subjects according to growth hormone …
  393. Docking and binding free energy calculations of sirtuin inhibitors
  394. Role of sirtuin proteins in life extension by caloric restriction
  395. Sirtuin 6 promotes transforming growth factor‐β1/H2O2/HOCl‐mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular …
  396. Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors
  397. #VALUE!
  398. Sirtuin 3 deficiency does not augment hypoxia-induced pulmonary hypertension
  399. Endoplasmic reticulum (ER) stress induces sirtuin 1 (SIRT1) expression via the PI3K-Akt-GSK3β signaling pathway and promotes hepatocellular injury
  400. Influence of age and physical exercise on sirtuin activity in humans.
  401. Association study of sirtuin 1 polymorphisms with bone mineral density and body mass index
  402. #VALUE!
  403. Activation of sirtuin 1/3 improves vascular hyporeactivity in severe hemorrhagic shock by alleviation of mitochondrial damage
  404. Mitochondrial Matrix Ca2+ Accumulation Regulates Cytosolic NAD+/NADH Metabolism, Protein Acetylation, and Sirtuin Expression
  405. Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol …
  406. Surprising sirtuin crosstalk in the heart
  407. Zebrafish as a model organism to evaluate drugs potentially able to modulate sirtuin expression
  408. Sirtuin 1 stabilization by HuR represses TNF-α- and glucose-induced E-selectin release and endothelial cell adhesiveness in vitro: relevance to human metabolic …
  409. D-galactosamine/lipopolysaccharide-induced hepatotoxicity downregulates sirtuin 1 in rat liver: role of sirtuin 1 modulation in hepatoprotection
  410. Activation of Kaposi’s sarcoma-associated herpesvirus (KSHV) by inhibitors of class III histone deacetylases: identification of sirtuin 1 as a regulator of the KSHV life …
  411. Aging: a sirtuin shake-up?
  412. Sirtuin 1 affects the transcriptional expression of adipose triglyceride lipase in porcine adipocytes
  413. Porcine sirtuin 1 gene clone, expression pattern, and regulation by resveratrol
  414. In Salmonella enterica, the sirtuin‐dependent protein acylation/deacylation system (SDPADS) maintains energy homeostasis during growth on low concentrations of …
  415. Sirtuin 1 is a key regulator of the interleukin-12 p70/interleukin-23 balance in human dendritic cells
  416. Simvastatin inhibits cysteine‐rich protein 61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of sirtuin‐1/FoxO3a signaling
  417. Mechanism-based modulator discovery for sirtuin-catalyzed deacetylation reaction
  418. Sirtuin 1 in skeletal muscle of cachectic tumour-bearing rats: a role in impaired regeneration?
  419. Sirtuin-3 modulates Bak-and Bax-dependent apoptosis
  420. Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer …
  421. Early hyperlipidemia promotes endothelial activation via a caspase-1-sirtuin 1 pathway
  422. Advanced glycation end‐products impair Na+/K+‐ATPase activity in diabetic cardiomyopathy: Role of the adenosine monophosphate‐activated protein kinase/sirtuin …
  423. Intersections between mitochondrial sirtuin signaling and tumor cell metabolism
  424. Tenovin-D3, a novel small-molecule inhibitor of sirtuin SirT2, increases p21 (CDKN1A) expression in a p53-independent manner
  425. A sirtuin link between metabolism and heart disease
  426. Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NFκB responses
  427. Serum sirtuin 1 levels in patients with polycystic ovary syndrome
  428. Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitors
  429. The Caenorhabditis elegans sirtuin gene, sir-2.1, is widely expressed and induced upon caloric restriction
  430. RETRACTED: Sirtuin-4 modulates sensitivity to induction of the mitochondrial permeability transition pore
  431. Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and …
  432. Capillary electrophoresis-based sirtuin assay using non-peptide substrates
  433. Pharmacologic targeting of sirtuin and PPAR signaling improves longevity and mitochondrial physiology in respiratory chain complex I mutant Caenorhabditis elegans
  434. Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts
  435. Chroman-4-one-and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells
  436. The deacetylase sirtuin 1 regulates human papillomavirus replication by modulating histone acetylation and recruitment of DNA damage factors NBS1 and …
  437. Sirtuin inhibition adversely affects porcine oocyte meiosis
  438. An integrated on‐chip sirtuin assay
  439. Sirtuin 1 in rat orthotopic liver transplantation: an IGL-1 preservation solution approach
  440. Sirtuin-targeting drugs: Mechanisms of action and potential therapeutic applications.
  441. Resveratrol via sirtuin-1 downregulates RE1-silencing transcription factor (REST) expression preventing PCB-95-induced neuronal cell death
  442. Caffeic acid attenuates rat liver reperfusion injury through sirtuin 3-dependent regulation of mitochondrial respiratory chain
  443. Sirtuin 3: a major control point for obesity-related metabolic diseases?
  444. Electrophoretically mediated microanalysis assay for sirtuin enzymes
  445. Virtual screening approach of sirtuin inhibitors results in two new scaffolds
  446. Advances in label-free screening approaches for studying sirtuin-mediated deacetylation
  447. … Induced by In Vivo Cerebral Oxidative Stress: Evidence for Beneficial Effects of SRT1720, a Sirtuin 1 Activator, and Sirtuin 1-Mediated Neuroprotective …
  448. Sirtuin 1 (SIRT1) Deacetylase Activity and NAD+/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death
  449. Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans
  450. Sirtuin 1 regulates SREBP-1c expression in a LXR-dependent manner in skeletal muscle
  451. Haplotype distribution in the class I sirtuin genes and their associations with ultrasound carcass traits in Qinchuan cattle (Bos taurus)
  452. Involvement of FOXO transcription factors, TRAIL-FasL/Fas, and sirtuin proteins family in canine coronavirus type II-induced apoptosis
  453. … -initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin is associated with increased sirtuin 1 activity in mice
  454. Resveratrol inhibits proliferation and promotes apoptosis of neuroblastoma cells: role of sirtuin 1
  455. Cyclic AMP signaling reduces sirtuin 6 expression in non-small cell lung cancer cells by promoting ubiquitin-proteasomal degradation via inhibition of the Raf-MEK …
  456. FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene, Sirtuin 2 (Sirt2)
  457. Quantification of endogenous sirtuin metabolite O-acetyl-ADP-ribose
  458. Sirtuin modulators: targets for metabolic diseases and beyond
  459. Caffeine ameliorates high energy diet-induced hepatic steatosis: sirtuin 3 acts as a bridge in the lipid metabolism pathway
  460. Development of a capillary electrophoresis‐based assay of sirtuin enzymes
  461. Evidence of a sirtuin gene family in grapevine (Vitis vinifera L.)
  462. Resveratrol, a sirtuin 1 activator, increases IL-6 production by peripheral blood mononuclear cells of patients with knee osteoarthritis
  463. Sirtuin 1 activator SRT1720 protects against lung injury via reduction of type II alveolar epithelial cells apoptosis in emphysema
  464. Receptor‐interacting protein (RIP) and Sirtuin‐3 (SIRT3) are on opposite sides of anoikis and tumorigenesis
  465. Molecular modeling study for conformational changes of Sirtuin 2 due to substrate and inhibitor binding
  466. Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy
  467. Breed difference and regulation of the porcine Sirtuin 1 by insulin
  468. Sirtuin type 1 mediates the retinal protective effect of hydrogen-rich saline against light-induced damage in rats
  469. The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis
  470. Changes in human sirtuin 6 gene promoter methylation during aging
  471. Sirtuin inhibitor sirtinol is an intracellular iron chelator
  472. Resveratrol attenuates intermittent hypoxia‑induced insulin resistance in rats: Involvement of Sirtuin 1 and the phosphatidylinositol‑4, 5‑bisphosphate 3‑kinase …
  473. Sirtuin 1 facilitates chemoresistance of pancreatic cancer cells by regulating adaptive response to chemotherapy‐induced stress
  474. The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells
  475. Efficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: the role of sirtuin 1 gene variants in human coronary atherosclerosis
  476. A mechanism-based potent sirtuin inhibitor containing Nε-thiocarbamoyl-lysine (TuAcK)
  477. Cyclin-dependent kinase 5–mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis
  478. Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control
  479. Quercetin, luteolin, and epigallocatechin gallate promote glucose disposal in adipocytes with regulation of AMP-activated kinase and/or sirtuin 1 activity
  480. Discovery of potent, proteolytically stable, and cell permeable human sirtuin peptidomimetic inhibitors containing Nε-thioacetyl-lysine
  481. The histone deacetylase sirtuin 2 is a new player in the regulation of platelet function
  482. Biologically Active Isoforms of CobB Sirtuin Deacetylase in Salmonella enterica and Erwinia amylovora
  483. Structural analysis of trypanosomal sirtuin: an insight for selective drug design
  484. Structure Function Analysis of Leishmania Sirtuin: An Ensemble of In Silico and Biochemical Studies
  485. Galloflavin suppresses lactate dehydrogenase activity and causes MYC downregulation in Burkitt lymphoma cells through NAD/NADH-dependent inhibition of sirtuin …
  486. Sirtuin 1 is a negative regulator of parathyroid hormone stimulation of matrix metalloproteinase 13 expression in osteoblastic cells: role of sirtuin 1 in the action of PTH …
  487. Resveratrol restores sirtuin 1 (SIRT1) activity and pyruvate dehydrogenase kinase 1 (PDK1) expression after hemorrhagic injury in a rat model
  488. Caffeic acid ethanolamide prevents cardiac dysfunction through sirtuin dependent cardiac bioenergetics preservation
  489. Genetic association of sirtuin genes and Parkinson’s disease
  490. Sulfated and Glucuronated trans-Resveratrol Metabolites Regulate Chemokines and Sirtuin-1 Expression in U-937 Macrophages
  491. Activation of sirtuin-1 promotes renal fibroblast activation and aggravates renal fibrogenesis
  492. Sirtuin 6 modulates hypoxia-induced apoptosis in osteoblasts via inhibition of glycolysis: implication for pathogenesis of periapical lesions
  493. Sirtuin gene polymorphisms are associated with chronic obstructive pulmonary disease in patients in Muğla province
  494. Fluorescence in situ hybridization and chromosomal organization of the sirtuin 4 gene (Sirt4) in the mouse
  495. Interplay between intravitreal RvD1 and local endogenous sirtuin-1 in the protection from endotoxin-induced uveitis in rats
  496. Cre-Mediated Stress Affects Sirtuin Expression Levels, Peroxisome Biogenesis and Metabolism, Antioxidant and Proinflammatory Signaling Pathways
  497. Icariin inhibits hydrogen peroxide‐mediated cytotoxicity by up‐regulating sirtuin type 1‐dependent catalase and peroxiredoxin
  498. Correction: Corrigendum: Sirtuin activators mimic caloric restriction and delay ageing in metazoans
  499. Sirtuin activity in dentate gyrus contributes to chronic stress-induced behavior and extracellular signal-regulated protein kinases 1 and 2 cascade changes in the …
  500. MicroRNA-199a induces differentiation of induced pluripotent stem cells into endothelial cells by targeting sirtuin 1
  501. Potent sirtuin inhibition bestowed by l-2-amino-7-carboxamidoheptanoic acid (l-ACAH), a N ε-acetyl-lysine analog
  502. Differential prooxidative effects of the green tea polyphenol,(–)‐epigallocatechin‐3‐gallate, in normal and oral cancer cells are related to differences in sirtuin 3 …
  503. Carob pod insoluble fiber exerts anti-atherosclerotic effects in rabbits through sirtuin-1 and peroxisome proliferator-activated receptor-γ coactivator-1α
  504. Reactive oxygen species and age-related genes p66Shc, sirtuin, FoxO3 and klotho in senescence
  505. Insight the C-site pocket conformational changes responsible for sirtuin 2 activity using molecular dynamics simulations
  506. E. coli endotoxin modulates the expression of Sirtuin proteins in PBMC in humans
  507. Pemetrexed induces apoptosis in malignant mesothelioma and lung cancer cells through activation of reactive oxygen species and inhibition of sirtuin 1
  508. 75‐kd sirtuin 1 blocks tumor necrosis factor α–mediated apoptosis in human osteoarthritic chondrocytes
  509. Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation
  510. Will the real aging Sirtuin please stand up?
  511. Nicotinamide phosphoribosyltransferase/sirtuin 1 pathway is involved in human immunodeficiency virus type 1 Tat‐mediated long terminal repeat transactivation
  512. Functional Characterization of Sirtuin-like Protein in Mycobacterium smegmatis
  513. Radiation-induced alteration of the brain proteome: understanding the role of the sirtuin 2 deacetylase in a murine model
  514. Sirtuin 1 regulates lipid metabolism associated with optic nerve regeneration
  515. Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1
  516. The sirtuin inhibitor sirtinol inhibits hepatitis A virus (HAV) replication by inhibiting HAV internal ribosomal entry site activity
  517. Human apolipoprotein E4 modulates the expression of Pin1, Sirtuin 1, and Presenilin 1 in brain regions of targeted replacement apoE mice
  518. Study of 1, 4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors
  519. c-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver
  520. Genomewide Screen for Negative Regulators of Sirtuin Activity in Saccharomyces cerevisiae Reveals 40 Loci and Links to Metabolism
  521. The novel growth factor, progranulin, stimulates mouse cholangiocyte proliferation via sirtuin-1-mediated inactivation of FOXO1
  522. Sirtuin 1 activity in peripheral blood mononuclear cells of patients with osteoporosis
  523. #VALUE!
  524. Over-expression of the Sirt3 sirtuin Protects neuronally differentiated PC12 Cells from degeneration induced by oxidative stress and trophic withdrawal
  525. STAT3‐dependent effects of IL‐22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation
  526. Prognostic significance of sirtuin 2 protein nuclear localization in glioma: an immunohistochemical study
  527. Transcription levels of sirtuin family in neural stem cells and brain tissues of adult mice
  528. Upregulation of long non-coding RNA HIF 1α-anti-sense 1 induced by transforming growth factor-β-mediated targeting of sirtuin 1 promotes osteoblastic …
  529. Modulation of insulin/IGFs pathways by sirtuin-7 inhibition in drug-induced chemoreistance
  530. Different patterns of lung sirtuin expression in smokers with and without chronic obstructive pulmonary disease
  531. N1-Benzyl substituted cambinol analogues as isozyme selective inhibitors of the sirtuin family of protein deacetylases
  532. Carprofen analogues as sirtuin inhibitors: enzyme and cellular studies
  533. Evaluation of benzoic acid derivatives as sirtuin inhibitors
  534. Sirtuin/uncoupling protein gene variants and carotid plaque area and morphology
  535. Molecular modelling studies of sirtuin 2 inhibitors using three-dimensional structure–activity relationship analysis and molecular dynamics simulations
  536. Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet
  537. Calorie restriction upregulated sirtuin 1 by attenuating its ubiquitin degradation in cancer cells
  538. Chitosan prevents adhesion during rabbit flexor tendon repair via the sirtuin 1 signaling pathway
  539. Natural mineral-rich water ingestion improves hepatic and fat glucocorticoid-signaling and increases sirtuin 1 in an animal model of metabolic syndrome
  540. Sirtuin 4 identification in normal human epidermal keratinocytes and its relation to sirtuin 3 and energy metabolism under normal conditions and UVB‐induced stress
  541. Cinnamon polyphenols attenuate the hydrogen peroxide-induced down regulation of S100β secretion by regulating sirtuin 1 in C6 rat glioma cells
  542. Prolonged fasting identifies heat shock protein 10 as a Sirtuin 3 substrate: elucidating a new mechanism linking mitochondrial protein acetylation to fatty acid oxidation …
  543. A succinyl lysine-based photo-cross-linking peptide probe for Sirtuin 5
  544. Up-regulation of the Sirtuin 1 (Sirt1) and Peroxisome Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) Genes in White Adipose Tissue of Id1 Protein-deficient …
  545. Design, synthesis and structure–activity relationship studies of novel Sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton
  546. Effect of Resveratrol on Leptin and Sirtuin 2 Expression in the Kidneys in Streptozotocin-induced Diabetic Rats.
  547. Sirtuin 6 nuclear localization at cortical brain level of young diabetic mice: an immunohistochemical study
  548. Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation
  549. Insight into the mechanism of intramolecular inhibition of the catalytic activity of sirtuin 2 (SIRT2)
  550. Sirtuin 1 is upregulated in young obese Zucker rat cerebral arteries
  551. Novel role of resveratrol: suppression of high-mobility group protein box 1 nucleocytoplasmic translocation by the upregulation of sirtuin 1 in sepsis-induced liver injury
  552. Cyclooxygenase-2–Derived Prostacyclin Regulates Arterial Thrombus Formation by Suppressing Tissue Factor in a Sirtuin-1–Dependent-Manner
  553. … quinine on ultraviolet A irradiation‑induced human dermal fibroblast senescence in vitro proceeds via the anti‑apoptotic sirtuin 1/nuclear factor‑derived …
  554. Fasting Induces Nuclear Factor E2-Related Factor 2 and ATP-Binding Cassette Transporters via Protein Kinase A and Sirtuin-1 in Mouse and Human
  555. Long-term high-fat consumption leads to downregulation of Akt phosphorylation of eNOS at Ser1177 and upregulation of Sirtuin-1 expression in rat cavernous tissue
  556. RETRACTED: Role of mammalian sirtuin 1 (SIRT1) in lipids metabolism and cell proliferation of goose primary hepatocytes
  557. Sirtuin to the rescue: SIRT 2 extends life span of B ub R 1 mice
  558. Characterization and differential expression analysis of complete coding sequences of Vitis vinifera L. sirtuin genes
  559. Cross-talk between canonical Wnt signaling and the sirtuin-FoxO longevity pathway to protect against muscular pathology induced by mutant PABPN1 expression in C …
  560. Sirtuin on a high-fat diet
  561. Post transcriptional control of the epigenetic stem cell regulator PLZF by sirtuin and HDAC deacetylases
  562. A neuroprotective role for sirtuin 1
  563. Age-related decrease of Sirtuin 2 protein in human peripheral blood mononuclear cells
  564. … slows aging and extends lifespan. Activators of the sirtuins, enzymes famously linked to this process, promise a wealth of new drugs–but the sirtuin hypothesis is now …
  565. Effects of resveratrol and trans-3, 5, 4′-trimethoxystilbene on glutamate-induced cytotoxicity, heme oxygenase-1, and sirtuin 1 in HT22 neuronal cells
  566. Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery
  567. Pleiotropic effects of the sirtuin inhibitor sirtinol involves concentration‐dependent modulation of multiple nuclear receptor‐mediated pathways in androgen …
  568. Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1
  569. Sirtuin inhibition increases the rate of non-homologous end-joining of DNA double strand breaks.
  570. The role of microRNAs in modulating sirtuin 1 expression
  571. Hepatic sirtuin 1 is dispensable for fibrate-induced peroxisome proliferator-activated receptor-α function in vivo
  572. K-Ras promotes the non-small lung cancer cells survival by cooperating with sirtuin 1 and p27 under ROS stimulation
  573. Sirtuin-1 mediates the obesity induced risk of common degenerative diseases: Alzheimer’s disease, coronary artery disease and type 2 diabetes
  574. Acetyltransferase SAS2 and sirtuin SIR2, respectively, control flocculation and biofilm formation in wine yeast
  575. A new nonpeptide substrate of human sirtuin in a capillary electrophoresis‐based assay. Investigation of the binding mode by docking experiments
  576. Pharmacophore modeling and molecular dynamics simulation to identify the critical chemical features against human sirtuin 2 inhibitors
  577. Discovery of a potent and highly fluorescent sirtuin inhibitor
  578. The effects of resveratrol on cyclooxygenase-1 and-2, nuclear factor kappa beta, matrix metalloproteinase-9, and sirtuin 1 mRNA expression in hearts of …
  579. The sirtuin family: regulators that connect metabolism, aging, and longevity
  580. #VALUE!
  581. Plasma membrane redox and control of sirtuin
  582. Sirtuin-mediated nuclear differentiation and programmed degradation in Tetrahymena
  583. Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis
  584. MicroRNA-204 inhibits proliferation, migration, invasion and epithelial-mesenchymal transition in osteosarcoma cells via targeting Sirtuin 1
  585. Novel sirtuin inhibitory warheads derived from the N ε-acetyl-lysine analog l-2-amino-7-carboxamidoheptanoic acid
  586. 9-Fluorenylmethoxycarbonyl-labeled peptides as substrates in a capillary electrophoresis-based assay for sirtuin enzymes
  587. Sorbitol dehydrogenase inhibitor protects the liver from ischemia/reperfusion-induced injury via elevated glycolytic flux and enhanced sirtuin 1 activity
  588. Sirtuin 1 agonist minimizes injury and improves the immune response following traumatic shock
  589. Association of the sirtuin and mitochondrial uncoupling protein genes with carotid intima-media thickness
  590. Complex regulation of the sirtuin-dependent reversible lysine acetylation system of Salmonella enterica
  591. Bone and calcium update; diagnosis and therapy of bone metabolism disease update. Regulatory Mechanism of Mammalian Sirtuin SIRT1 in Vascular calcification …
  592. Circadian measurements of sirtuin biology
  593. Entamoeba histolytica sirtuin EhSir2a deacetylates tubulin and regulates the number of microtubular assemblies during the cell cycle
  594. Sirtuin inhibitor Ex‐527 causes neural tube defects, ventral edema formations, and gastrointestinal malformations in Xenopus laevis embryos
  595. Sirtuin 3 in acute kidney injury
  596. Effects of maternal aging on expression of sirtuin genes in ovulated oocyte and cumulus cells
  597. Effects of natural mineral-rich water consumption on the expression of sirtuin 1 and angiogenic factors in the erectile tissue of rats with fructose-induced …
  598. Poly (ADP-ribose) polymerase 1-sirtuin 1 functional interplay regulates LPS-mediated high mobility group box 1 secretion
  599. Sirtuin 3: a molecular pathway linking sleep deprivation to neurological diseases
  600. Extracellular-signal-regulated kinase 5 modulates the antioxidant response by transcriptionally controlling Sirtuin 1 expression in leukemic cells
  601. N,N’-Bisbenzylidenebenzene-1,4-diamines and N,N’-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors
  602. Sirtuin activation: a role for plasma membrane in the cell growth puzzle
  603. Viral genome silencing by neuronal sirtuin 1
  604. Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection
  605. Chromosomal characterization and localization of the NAD+-dependent histone deacetylase gene sirtuin 1 in the mouse
  606. Apelin gene therapy increases autophagy via activation of Sirtuin 3 in diabetic heart
  607. … monophosphate–activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside treatment increases the sirtuin 1 protein expression in …
  608. … disease, health, & longevity: Sirtuin 1 often decreases with advanced age & serious diseases in most parts of the human body, while relatively high & constant Sirtuin …
  609. MicroRNA‑34a induces apoptosis in PC12 cells by reducing B‑cell lymphoma 2 and sirtuin‑1 expression
  610. Impact of angiotensin II on skeletal muscle metabolism and function in mice: contribution of IGF-1, Sirtuin-1 and PGC-1α
  611. Renal protective effect of sirtuin 1
  612. Food for thought: linking caloric intake to behavior via sirtuin activity
  613. 3-(N-arylsulfamoyl) benzamides, inhibitors of human Sirtuin type 2 (SIRT2)
  614. Effect of resveratrol and lipoic acid on sirtuin-regulated expression of metabolic genes in bovine liver and muscle slice cultures
  615. Sirtuin functions in the brain: From physiological to pathological aspects
  616. Small molecule modulators of sirtuin activity
  617. Genomic organization and localization of the NAD-dependent histone deacetylase gene sirtuin 3 (Sirt3) in the mouse
  618. Sirtuin 3—a master regulator of mitochondrial integrity in AKI
  619. Sirtuin 1 suppresses nuclear factor κB induced transactivation and pro-inflammatory cytokine expression in cat fibroblast cells
  620. Functionalized tetrahydro-1H-pyrido [4, 3-b] indoles: a novel chemotype with Sirtuin 2 inhibitory activity
  621. Emerging drug target in pancreatic cancer: placing sirtuin 1 on the canvas
  622. Inhibition of Sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intake
  623. Interleukin 6 increases dysfunction of organs in sepsis rats through sirtuin 1
  624. Sirtuin 1 as a key player of ‘metabolic memory’
  625. … 7-alkylidene-7, 12-dihydroindolo [3, 2-d] benzazepine-6-(5 H)-ones (7-alkylidene-paullones) by N-cyclization–oxidative Heck cascade and characterization as sirtuin …
  626. Complex roles of Sirtuin 1 in cancer and aging
  627. In vivo measurement of the acetylation state of sirtuin substrates as a proxy for sirtuin activity
  628. Sirtuin 3 is down-regulated in Apolipoprotein E4 carriers with Alzheimer’s disease (P5. 011)
  629. Carbohydrate-responsive element-binding protein, Sirtuin 1, and ethanol metabolism: a complicated network in alcohol-induced hepatic steatosis.
  630. A pro-apoptotic role for sirtuin 3
  631. Correction: discovery of a potent and highly fluorescent sirtuin inhibitor
  632. Development of a nuclear-localized fluorescent probe for hydrogen peroxide and applications to the study of sirtuin-mediated oxidative stress responses in …
  633. SIRT3 deacetylase: the Jekyll and Hyde sirtuin
  634. A multicancer-like syndrome in a dog characterized by p53 and cell cycle-checkpoint kinase 2 (CHK2) mutations and sirtuin gene (SIRT1) down-regulation
  635. The histone deacetylase inhibitor cambinol prevents acidic pHe-induced anterograde lysosome trafficking independently of sirtuin activity
  636. Identification of a new nicotinamide binding site in a sirtuin: a reassessment
  637. Sirtuin mediated neuroprotection and its association with autophagy and apoptosis: Studies employing transgenic C. elegans model
  638. Sirtuin-Dependent Metabolic Control and Its Role in the Aging Process
  639. Relationship between sirtuin and mitochondrial uncoupling protein genes and carotid artery stiffness
  640. Influence of Olmesartan on Sirtuin 1 mRNA expression in 5/6 Nephrectomized spontaneously hypertensive rats
  641. Still un-sirtuin
  642. … -indazol-6-amines and indoles: a greener approach to the synthesis of exo-1, 6, 7, 7a, 12, 12a-hexahydroindolo [3, 2-c] pyrazolo [3, 4-f] quinolines as potential sirtuin …
  643. Continuous multiparametric monitoring of cell metabolism in response to transient overexpression of the sirtuin deacetylase SIRT3
  644. Detecting Sirtuin-Catalyzed Deacylation Reactions Using 32P-Labeled NAD and Thin-Layer Chromatography
  645. Cloning, chromosomal characterization and FISH mapping of the NAD+-dependent histone deacetylase gene sirtuin 5 in the mouse
  646. Cell size control is sirtuin (ly) exciting
  647. #VALUE!
  648. Inhibition of microRNA-9-3p reduces lipid accumulation in HepG2 cells by targeting the expression of sirtuin type 1
  649. Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and …
  650. Salermide down-regulates sirtuin proteins to induce human cancer cell apoptosis
  651. Sirtuin expression is decreased in malignant breast tissue and is associated with patient outcome.
  652. Emerging Roles of the Sirtuin Family
  653. Up-regulation of Fas ligand expression by sirtuin 1 in both flow-restricted vessels and serum-stimulated vascular smooth muscle cells
  654. Sirtuin, an oxidant sensitive deacetylase, is post‐translationally modified and degraded by the proteasome in response to cigarette smoke in lung epithelial cells
  655. Effects of the sirtuin inhibitor, salermide, on exercise‐induced changes in endothelial function
  656. Response to Comment on Balestrieri et al. Sirtuin 6 Expression and Inflammatory Activity in Diabetic Atherosclerotic Plaques: Effects of Incretin Treatment. Diabetes …
  657. Role of Sirtuin 6 in the Initiation and Progression of Calcific Aortic Valve Disease
  658. Effect of weight maintenance or gain in a 10 years period over telomere length, sirtuin 1 and 6 expression and carotid intima media thickness
  659. Sirtuin function in longevity
  660. Preliminary observations on the role of sirtuin genes in grapevine (Vitis vinifera L.) physiology
  661. Sirtuin 3 inhibits cardiomyocyte apoptosis by reducing cytochrome C release in myocardiac H9c2 cells with calcium overload
  662. Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1
  663. Correction: mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studies
  664. C. elegans sirtuin SIR-2.4 and its mammalian homolog SIRT6 in stress response
  665. Targeting Sirtuin to Modulate Human Inflammation
  666. 59 Endothelial colony forming cells (ECFC) are senescent and dysfunctional in COPD due to reduced sirtuin-1 levels
  667. Overexpression of the Sirtuin Sirt1 Increases Insulin Sensitivity in Aging Mice.
  668. Generating Mammalian Sirtuin Tools for Protein-Interaction Analysis
  669. Melatonin drives beneficial Sirtuin 1 expression in leptin-deficient mice liver through MT1 receptor
  670. The research development of deacetylase (Sirtuin)
  671. Impact of aging on the angiogenic potential of the myocardium: implications for angiogenic therapies with emphasis on sirtuin agonists
  672. Characterization of Sirtuin Proteins using RasMol‐RP and Three Dimensional Modeling
  673. 22 Sirtuin and Resveratrol
  674. Studying the Role of Sirtuin-1 Gene in the Maintenance of Mouse Intestinal Epithelium
  675. Examination of the cytoprotective role of Sirtuin-1 in the renal medulla
  676. Sirtuin expression is downregulated in non‐small cell lung cancer
  677. Relation of Sirtuin 1 Gene Polymorphisms with Lipid Profile in Hemodialysis Patients
  678. Aging and Non-sirtuin Histone Modifications
  679. Synergy between metformin and leucine in sirtuin signaling and fat oxidation in vitro, and in reducing lipid accumulation in diet-induced obese mice
  680. Back nonhomologous end-joining is the target of sirtuin inhibitor
  681. Resveratrol: A sirtuin activator and the fountain of youth
  682. Sirtuin 1 Maitains Survival via PKB Signaling in Degenerative Human Disc Nucleus Pulposus Cells [J]
  683. Sirtuin; Molecular Target for Antiaging
  684. The role of sirtuin 3 in the differential pro‐oxidant effects of (‐)‐epigallocatechin‐3‐gallate in oral cells (261.4)
  685. The mitochondrial sirtuin SIRT3 promotes survival of human melanoma cells in vitro
  686. Role of sirtuin 3 on mitochondrial dynamics in Huntington’s disease striatal cells
  687. Cloning and characterization of NAD-dependent deacetylase sirtuin 2 homolog from the silkworm, Bombyx mori
  688. Association Between A Sirtuin 5 SNP (rs SIRT5 SNP, rs9382222) And Three Functional Markers Of Brain Health
  689. Sirtuin-induced protein deacetylation affects the heat shock response in blue mussel congeners (Mytilus)
  690. Sirtuin‐1 gain of function increases endothelium‐dependent vasorelaxation of murine femoral arteries
  691. Increased Pulmonary Vascular and Systemic Response to Chronic Hypoxia in Sirtuin 1 Mutant Mice: a Role for Hypoxia-inducible Factor-3α?
  692. PROGRESS IN FUNCTIONS AND REGULATION OF SIRTUIN
  693. Investigations of sirtuin metabolism
  694. Sirtuin Inhibition in Combination with Histone Deacetylase (HDAC) Inhibition Is Effective Therapy for Aggressive B-Cell Lymphomas in Both Pre-Clinical and Clinical …
  695. Sirtuin polymorphisms and methods of use thereof
  696. Hdac6 and Sirtuin Inhibitors Protect Against Tachypacing-Induced Contractile Dysfunction in in vitro and in vivo Models for Atrial Fibrillation.
  697. The differential effects of Sirtuin-3 in cardio-protection
  698. Breed difference of porcine Sirtuin 1, adipose triglyceride lipase (ATGL) and hormone sensitive lipase (HSL)
  699. Role of sirtuin genes in longevity
  700. Modulating Sirtuin Activity
  701. … -1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic acid methyl ester (MIAM) inhibited human hepatocellular carcinoma growth through upregulation of Sirtuin-3 …
  702. Withdrawal: Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a …
  703. Steroid boost for sirtuin research
  704. Un-sirtuin effects of natural products
  705. Comment on “Renal Protective Effect of Sirtuin 1”
  706. Emerging Roles of the Sirtuin Family in Cancer
  707. The Chemistry and Biology of Sirtuin Enzymes
  708. A sirtuin switch in the brain
  709. Sirtuin on a high-fat diet
  710. Sirtuin 6 expression in breast cancer
  711. Nutrition, Aging, and Sirtuin
  712. Mechanism-based sirtuin enzyme activation
  713. The Flavoring Agent Dihydrocoumarin Is An Epigenetic Toxicant That Inhibits Sirtuin Deacetylases
  714. Expression of sirtuin in hepatocellular carcinoma and its clinical significance
  715. Studying sirtuin inhibitors with in silico and in vitro approaches
  716. Studies Towards Biochemical Characterization Of A Novel Activity For Sirtuin 6
  717. Antitumor Effects of a Sirtuin Inhibitor
  718. Modulating Sirtuin Activity-Design, Synthesis and Evaluation of Sirtuin 2 Inhibitors
  719. INFLUENCE OF AGE AND PHYSICAL EXERCISE ON SIRTUIN ACTIVITY IN HUMANS
  720. Radiation-induced autophagy is dependent on Sirtuin 3.
  721. Sort-term sirtuin inhibition does not affect survival of CHO and xrs6 cells
  722. Sirtuin protein linked to longevity in mammals
  723. Application of computer-based methods to guide the development of novel sirtuin inhibitors-[kumulative Dissertation]
  724. Sirtuin 1 in Steatotic and Non Steatotic Liver Graft Preservation: Differential Aspects.: Abstract# C1664
  725. Sirtuin-mediated mechanisms of homeostasis and aging in metazoans
  726. Novel Cambinol Analogs as Sirtuin Inibitors: Synthesis and Biological Evaluation.
  727. Perspectives on pharmacological and clinical benefits from sirtuin 1 activators in oxidative damage
  728. Skeletal muscle regeneration and the role of Sirtuin 1
  729. Structure-based Development of a Sirtuin 2 Affinity Probe
  730. Quantitation of sirtuin activity with a one-step luminescent assay
  731. Effect of caloric restriction on the expression of the Sirtuin Proteins
  732. Role Of Sirtuin 6 In Macrophage Polarization In Diabetes
  733. Novel assays for Sirtuin and PARP families utilizing unmodified substrates
  734. A Review of the Sirtuin System, its Clinical Implications, and the Potential Role of Dietary Activators like Res…
  735. Resveratrol and Synthetic Sirtuin Activators
  736. Comment on Sirtuin 1 in skeletal muscle of cachectic tumour-bearing rats
  737. Preliminary observations on the role of sirtuin genes in grapevine physiology.
  738. Structural and Biochemical Studies of Histone Acetyltransferases and Sirtuin Enzymes
  739. Sirtuin 6 localization at cortical brain level of young diabetic mice
  740. Selective Targeting of Sirtuin Isoforms for Cancer Therapeutics
  741. Identification and characterization of novel sirtuin inhibitors against aging-related diseases
  742. Understanding the Role of Sirtuin 3 in a Cell Model of Parkinson’s Disease
  743. Late-breaking abstract: Decreased sirtuin expression in squamous cell carcinoma compared to adenocarcinoma
  744. SIRT5 Mutants Reveal Insights into Sirtuin Regulation
  745. Sirtuin 2 in hypothalamus: an emerging target in insulin resistance?
  746. Light-dark Condition Regulates Sirtuin Genes in the Retina
  747. Regulation of Mitochondrial Functions by Sirtuin Proteins in Heart Failure
  748. Targeting sirtuin-1 improves murine renal allograft survival and function (TRAN3P. 901)
  749. CHARACTERIZATION AND STUDY OF VITIS VINIFERA L. SIRTUIN GENES
  750. Protection against age-related neuronal frailty by sirtuin 1 enhancement
  751. Weight loss with preserved glucose homeostasis during chronic treatment of obese mice with 3-iodothyronamine (T1AM): role of the sirtuin family
  752. The Role of Sirtuin-2 in Tubular Forming Activity of Human Umbilical Vein Endothelial Cells
  753. The Angiogenic Defect in Diabetes is Reversed by the Activation of Sirtuin 1
  754. THE ACTIVITY OF SIRTUIN 1 IN MCF-7 BREAST CANCER CELL LINE: THE EFFECTS OF VISFATIN
  755. To sirtuin with love: caloric restrictions and the genes of the aging brain
  756. Role of Sirtuin 6 in Macrophage Polarization and Cardiac Repair in Diabetes
  757. Role Of Sirtuin-6 In Maintenance Of Genomic Instability In Multiple Myeloma Cells
  758. Sirtuin 1 and angiotensin II as inflammatory modulators in the development of diabetes
  759. Characterization of Sirtuin family protein expression in human trabecular meshwork cells
  760. Molecular Mechanisms and Biological Functions of the NAD +-dependent Deacylase Sirtuin-6
  761. Sirtuin 1 Modulates Cardiac Sodium Channels in vivo
  762. Characterization of the NAD-Dependent Human Histone Deacetylases Gene Sirtuin 1 and Its Implications on Aging and the Development of Malignant Disease.
  763. Sirtuin 1 reduction causes activation of Wnt/b catenin signalling
  764. AB0610 No changes in sirtuin-1 (hdac 3) activity from pbmc of patients with osteoporosis
  765. Over Expression of Wild Type or a Catalytically Dead Mutant of SIRTUIN 6 Does
  766. Exploring the role of sirtuin deacetylases in regulating megakaryocyte and erythrocyte differentiation
  767. Sirtuin 2 expression in uveal melanoma correlates with metastasis in an animal model
  768. Variant analysis of the Sirtuin [SIRT1] gene in multiple sclerosis
  769. Increased sirtuin expression in patient with lung squamous cell carcinoma co-morbid with COPD
  770. Mechanism-Based Peptidic and Peptidomimetic Human Sirtuin Inhibitors
  771. Sirtuin inhibition increases the rate of DNA double strand break repair in xrs6 cells
  772. AB0019 Change in MRNA Expression of Sirtuin-2 and Sirtuin-3 in Rheumatoid Arthritis
  773. The role of MnSOD and sirtuin 3 in thymocyte responses to radiation and lymphomagenesis
  774. Sirtuin 1 is a key regulator of the IL-12 p70/IL-23 balance in human dendritic cells
  775. Novel cambinol analogues as potential anticancer agents: an improved understanding of sirtuin isoform selectivity
  776. Role of Sirtuin 3 on Doxorubicin-induced Toxicity on H9c2 Cardiomyoblasts
  777. Roles for the Human Sirtuin SIRT7 in Chromatin Regulation and Cancer
  778. Development of sirtuin and calmodulin-dependent protein kinase inhibitors as anti-cancer therapeutics
  779. EXPERIMENTAL CARDIOVASCULAR AND LUNG RESEARCH Sirtuin gene polymorphisms are associated with chronic obstructive pulmonary disease in patients in …
  780. Mitochondrial Complex II is a Source of the Reserve Respiratory Capacity that is Regulated by Metabolic Sensors via Sirtuin 3
  781. Synergistic Interactions between HDAC and Sirtuin Inhibitors in Human Leukemia Cells
  782. Leucine and Resveratrol: Experimental Model of Sirtuin Pathway Activation
  783. Anti-Inflammatory Role for Sirtuin-1 Activators in a Peptide-Induced B10riii Model of Experimental Autoimmune Uveitis
  784. Antitumor Effects of a Sirtuin Inhibitor, Tenovin-6, against Gastric Cancer Cells via Death Receptor 5 Up-Regulation
  785. Exercise-Induced Sirtuin Expression in Blood Vessels and Skeletal Muscles of Rats
  786. Decreased persistence of {gamma} H2AX foci in x-irradiated xrs6 cells treated with sirtuin inhibitor
  787. Sirtuin 1 is a key regulator of the IL-12 p70/IL-23 balance in human dendritic cells (DC)
  788. Sirtuin 1 induces autophagy to suppress liver ischemia/reperfusion injury in mice (1115.1)
  789. Regulation of energy homeostasis by hypothalamic Sirtuin 1 and endoplasmic reticulum stress
  790. Activation of Sirtuin 3 Protects the Heart From Ischemia-Reperfusion Injury by Increased Cellular Antioxidant Defenses
  791. Assessing the Cytoprotective Properties and Central Nervous System Expression Profile of Mammalian Sirtuin SIRT3
  792. Abstract A73: Altered expression of sirtuin 1 and Deleted in Breast Cancer 1 and its functional impact on pancreatic carcinogenesis.
  793. Ethanol intoxication increases hepatic mitochondrial protein acetylation but not through sirtuin inhibition
  794. A proteomics view of SIRT6 functions and the anti-viral roles of sirtuin proteins
  795. Sirtuin 1 mediates acidosis-induced metabolic reprogramming of tumor cells
  796. Sirtuin 1 mediates acidosis-induced metabolic reprogramming of tumor cells
  797. Emerging Role of Sirtuin 1 in Rat Orthotopic Liver Transplantation Using IGL-1 Preservation Solution.: Abstract# C1656
  798. Structural and biochemical insights into the mechanism of sirtuin catalysis and regulation by nicotinamide and small molecule inhibitors
  799. Upregulated sirtuin 5 gene expression in frontal cortex of serotonin 1b receptor knock out mice
  800. Comment on Balestrieri et al. Sirtuin 6 Expression and Inflammatory Activity in Diabetic Atherosclerotic Plaques: Effects of Incretin Treatment. Diabetes 2015; 64: 1395 …
  801. Virtual screening and binding free energy calculations of sirtuin inhibitors
  802. Sirtuin-3 (SIRT3), a novel potential therapeutic target for head and neck cancer
  803. Neuroprotective Role of Sirtuin (SIRT1) Against Hypoxia in Retinal Ganglion Cells
  804. Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation
  805. Correction: Correction: Mechanism of Inhibition of the Human Sirtuin Enzyme SIRT3 by Nicotinamide: Computational and Experimental Studies
  806. Hypoxia-Induced Decrease In Cardiac Stem Cell Proliferation Is Associated With Downregulation Of Sirtuin 1
  807. Sirtuin-1 Activation Has no Effect on Aortic Root Dilatation in Marfan Mice
  808. The sirtuin activating compound resveratrol decreases GH transcription
  809. SIRTUIN 1 REGULATES AMYLOID BETA OLIGOMER METABOLISM IN HEP G2 CELLS WITH RELEVANCE TO DIET AND ALZHEIMER’S DISEASE
  810. AMP-activated protein kinase, Sirtuin 1, and p53 interactions in HEPG2 cells
  811. Regulation of sirtuin 6 protein expression by cyclic AMP signaling system in non-small cell lung cancer cells
  812. TR-FRET Assay for Sirtuin 1 (SIRT1) Inhibitor Screening
  813. Sirtuin 2 mediated-deacetylation regulates cellular iron homeostasis
  814. Sirtuin regulation of lysine acylation targets diverse metabolic networks in hepatic mitochondria (981.3)
  815. Sirtuin 1 enzyme activity and autophagy proteins are increased in the kidney during murine sepsis
  816. Sirtuin-1 Induced Reduction Of Pulmonary Artery Smooth Muscle Cell Proliferation And Hypertrophy
  817. #VALUE!
  818. Shear Stress Increases Sirtuin‐1 Expression to Mediate Shear‐Induced Autophagy in Endothelial Cells
  819. Sirtuin-3 is Essential for Glucagon-like Peptide-1-mediated Restoration of Diabetic Cardiomyopathy
  820. Hypoxia-Induced Downregulation of Sirtuin 1 Impairs Cardiac Stem Cell Proliferation
  821. Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells (MUC2P. 818)
  822. SAT0323 Resveratrol, a Sirtuin-1 (HDAC 3) Activator, Increases IL-6 Production by PBMC of Patients with Knee Osteoarthritis.
  823. Identification of Novel Acetylation Sites in Nrf1 (NFE2L1) and Their Regulation by Sirtuin 1 (SIRT1)
  824. Sirtuin 1 (Sirt1) regulates the HSF1-dependent pro-survival mechanism in neurons
  825. The Role of Sirtuin 1 and Ceramide in t10c12 Conjugated Linoleic Acid Induced Delipidation in 3T3-L1 Adipocytes
  826. A novel sirtuin inhibitor, AS4. 064, enhances apoptosis and acetylation of targets in hematological lines in combination with the novel HDACi, SelSA-1.
  827. Annexin-A1 Biomimetic Peptide Attenuates Myocardial Ischemia-Reperfusion Injury via Increased Sirtuin-3
  828. The Sirtuin SIRT3 Blocks Doxorubicin-induced Cardiac Hypertrophic Response of Mice
  829. Acute doxorubicin treatment induces proteome lysine deacetylation, with no change in sirtuin expression, in the heart and liver of fasted animals
  830. … Induced by In Vivo Cerebral Oxidative Stress: Evidence for Beneficial Effects of SRT1720, a Sirtuin 1 Activator, and Sirtuin 1-Mediated Neuroprotective Effects of Poly …
  831. Structural Basis for Enzyme Promiscuity and Specificty-Insights from Human Cytosolic sulfotransferase (SULT) and Sirtuin (SIRT) Families
  832. Role of myelin-associated NAD⁺-dependent deacetylase Sirtuin 2 in modifying axonal degeneration
  833. SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy
  834. Alzheimer research forum live discussion: Meet new players, histone deacetylase and sirtuin-Will they help the cell cycle, DNA repair, and gene expression break into …
  835. Microrna-34a Regulates Smooth Muscle Cell Differentiation from Stem Cells by Targeting Sirtuin 1
  836. #VALUE!
  837. A targeted knockdown of sirtuin histone deacetylase Sirt1 imparts significant growth inhibitory effects in human prostate cancer cells.
  838. Sirtuin‐1‐dependent COX2 Induction is an Essential Survival Mechanism in Renal Medullary Interstitial Cells against Oxidative Stress
  839. The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells
  840. Sirtuin 3 inhibited HBV replication by deacetylating HBV cccDNA-bound histone H3 and antagonized the oxidative stress induced by HBV infection
  841. Ionizing Radiation-induced Apoptosis of Cerebral Microvascular Endothelium Occurs with Mitochondrial Mediated Sirtuin, p53, and Grp75 Expression
  842. Sirtuin (Sirt1/Sirt2) protect human pluripotent stem cells from DNA damage-induced apoptosis
  843. Resveratrol-Sirtuin 1 Pathway: Beneficial Effects of White Wine and Resveratrol Intake on Lung Function in the General Population.
  844. MicroRNA-34a Regulated Sirtuin 1 is Required for Smooth Muscle Cell Differentiation From Murine and Human Embryonic Stem Cells
  845. Cold acclimation increases levels of some heat shock protein and sirtuin isoforms in threespine stickleback Part A Molecular & integrative physiology
  846. Effect of resveratrol and lipoic acid on sirtuin-regulated expression of metabolic genes in bovine liver and muscle slice cultures1, 2
  847. The [NAD+ over Sirtuin] Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
  848. Homology modeling, Molecular Dynamic Simulation and in silico screening of Activator for the Intensification of human sirtuin type 1 (SIRT1) by novel 1, 3, 4 …
  849. The sirtuin activator represses glucokinase expression via the combined action of FoxO1 and HNF-4
  850. Reversible Protein Acetylation in the Mitochondria: Cellular and Molecular Function of the NAD+ Dependent Deacetylase Sirtuin 3
  851. Abstract LB-209: SIRT3, a mitochondrial sirtuin deacetylase, promotes survival of human melanoma cells.
  852. Chemical biology studies on 5-nitrofurans and sirtuin inhibitors
  853. Receptor interacting protein (RIP) and Sirtuin-3 (SIRT3) on opposite sides of anoikis resistance and promotes tumorigenesis
  854. Effects of sirtuin 6/nuclear factor κB signaling pathway in delaying hematopoietic stem cell and progenitor cell senescence with ginsenoside R1 during serial …
  855. Modulations of sirtuin 1 protein levels by nicotine and β‐cryptoxanthin can be mediated by miR‐34a in A/J mice lung cancer model
  856. OP0192 Sirtuin Deacetylase 2 Inhibition Suppresses Inflammatory Activation of Rheumatoid Arthritis Fibroblast-Like Synoviocytes and IFN-Γ–Differentiated …
  857. #VALUE!
  858. Water soluble cinnamon extract reverses the hydrogen peroxide‐induced down regulation of S100 β secretion and sirtuin protein expression in C6 rat glioma cells
  859. Synergistic Effects of Leucine and β‐Hydroxy‐β‐Methyl‐Butyrate (HMB) with Phosphodiesterase (PDE) Inhibitors on Sirtuin Activation
  860. The Mitochondrial Deacetylase Sirtuin 3 (sirt3) is Important in the Pathogenesis of Both Pulmonary Hypertension and Pulmonary Fibrosis: Potential for an “Overlap …
  861. The Role of Sirtuin Inhibitors on the Proteomic Responses of the Mussels Mytilus galloprovincialis and Mytilus trossulus to Menadione Induced Oxidative Stress
  862. The novel Sirtuin inhibitor AS4. 064 induces apoptosis in lymphoid malignancy lines and regulates transcription of spliceosome components and the metabolic …
  863. Carcinogenic Compounds, 2-nitrofluorene and Clonidine Can Modulate the Level of Sirtuin mRNAs Expression in Human Adipose Tissue-derived Stem Cells
  864. 2 Light–dark condition regulates sirtuin mRNA levels in the retina
  865. Linking the pro‐oxidant influences of epigallocatechin gallate (EGCG) to intestinal cholesterol metabolism via alterations in sirtuin 1 (SIRT1) using Caco‐2 cells
  866. Mitochondrial Sirtuin 3 and Sirtuin 5 in granulosa and cumulus cells and their contribution to the altered follicular environment in women with either reduced ovarian …
  867. B27 VIRAL INFECTION AND PEDIATRIC ASTHMA: Resveratrol, A Sirtuin-1 Agonist, Inhibits Respiratory Syncytial Virus Infection By Decreasing Viral Replication …
  868. 12 Mitochondrial Protein Acetylation and Sirtuin-Mediated Deacetylation
  869. SIN‐1 cause downregulation of sirtuin expression in mouse astrocytes
  870. 774: Placental visfatin/NAMPT and sirtuin-1 expression in pre-eclampsia
  871. Mitofusin 2 mediates Sirtuin 1 induced autophagy to suppress liver ischemia/reperfusion injury
  872. … ACUTE EFFECTS OF INTENSE CARDIORESPIRATORY EXERCISE ON HUMAN TELOMERASE REVERSE TRANSCRIPTASE AND SIRTUIN 6 EXPRESSION IN …
  873. Tetrahymena Histone Deacetylase 14, a Stress-Responsive Class I Sirtuin That Changes Localization and Expression in Response to Genotoxic and Metabolic Stress
  874. 0273: Role of Sirtuin 3 in cardioprotection–evolution with aging
  875. 128. A ROLE FOR SIRTUIN 3 IN THE DEVELOPING MAMMALIAN EMBRYO
  876. Effect of weight maintenance or gain in a 10 years period over telomere length, sirtuin 1 and 6 expression and carotid intima media thickness
  877. Serum and Glucocorticoid-Inducible Kinase 1 Regulates Sirtuin 3, the Mitochondrial Deacetylase via Phosphorylation and Sumoylation Mechanisms in Rat Aortic …
  878. #VALUE!
  879. 2Chapter 2 Sirtuin and Resveratrol
  880. P3. 40 Potential role of sirtuin-1 as druggable target in muscular dystrophy: effect of a chronic resveratrol treatment on in vivo and ex vivo pathological signs of …
  881. Sirtuin functions and modulation: from chemistry to the clinic
  882. Mechanisms and disease implications of sirtuin-mediated autophagic regulation
  883. Sirtuin activators and inhibitors: promises, achievements, and challenges
  884. Sirtuin signaling in cellular senescence and aging
  885. Role of sirtuin-1 in diabetic nephropathy
  886. The sirtuin family in cancer
  887. Sirtuin inhibition: strategies, inhibitors, and therapeutic potential
  888. Natural polyphenols as sirtuin 6 modulators
  889. Sirtuin 1 and Alzheimer’s disease: an up-to-date review
  890. Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
  891. The roles of sirtuin family proteins in cancer progression
  892. Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology
  893. Decreased serum sirtuin-1 in COPD
  894. Role of Sirtuin 1 in the pathogenesis of ocular disease
  895. Structural basis of sirtuin 6 activation by synthetic small molecules
  896. Mitochondrial sirtuin 3 and renal diseases
  897. Sirtuin 3 deregulation promotes pulmonary fibrosis
  898. Structure‐Based Development of an Affinity Probe for Sirtuin 2
  899. Hippocampal sirtuin 1 signaling mediates depression-like behavior
  900. Sirtuin 1 and oral cancer
  901. Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives
  902. High-throughput screening of Sirtuin family of genes in breast cancer
  903. Emerging roles of Sirtuin 6 in Alzheimer’s disease
  904. Sirtuin 5: a review of structure, known inhibitors and clues for developing new inhibitors
  905. Mechanism‐based inhibitors of the human sirtuin 5 deacylase: structure–activity relationship, biostructural, and kinetic insight
  906. A continuous, fluorogenic sirtuin 2 deacylase assay: substrate screening and inhibitor evaluation
  907. Sirtuin 6, a possible therapeutic target for type 2 diabetes
  908. Finding reactive configurations: a machine learning approach for estimating energy barriers applied to Sirtuin 5
  909. Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer
  910. The role of sirtuin 1 and its activator, resveratrol in osteoarthritis
  911. Quercetin based derivatives as sirtuin inhibitors
  912. Advances in cellular characterization of the sirtuin isoform, SIRT7
  913. Decline in Sirtuin-1 expression and activity plays a critical role in blood-brain barrier permeability in aging
  914. Mitochondrial sirtuin network reveals dynamic SIRT3-dependent deacetylation in response to membrane depolarization
  915. Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury
  916. Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium
  917. The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
  918. Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice
  919. Sirtuin 3 deficiency accelerates hypertensive cardiac remodeling by impairing angiogenesis
  920. Loss of sirtuin 1 alters the secretome of breast cancer cells by impairing lysosomal integrity
  921. Protective effects of sirtuin 3 in a murine model of sepsis-induced acute kidney injury
  922. Investigating the sensitivity of NAD+-dependent sirtuin deacylation activities to NADH
  923. Sirtuin 5 is required for mouse survival in response to cardiac pressure overload
  924. Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation
  925. Sirtuin 1 attenuates nasal polypogenesis by suppressing epithelial-to-mesenchymal transition
  926. State of the art–sirtuin 1 in kidney pathology–clinical relevance
  927. Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression
  928. Loss of sirtuin 1 and mitofusin 2 contributes to enhanced ischemia/reperfusion injury in aged livers
  929. Potent and selective inhibitors of human sirtuin 5
  930. Regulation of sirtuin-mediated protein deacetylation by cardioprotective phytochemicals
  931. The future of genomic medicine involves the maintenance of sirtuin 1 in global populations
  932. Structural basis of sirtuin 6 inhibition by the hydroxamate trichostatin A: implications for protein deacylase drug development
  933. Sirtuin 3-induced macrophage autophagy in regulating NLRP3 inflammasome activation
  934. Sirtuin 7: a new marker of aggressiveness in prostate cancer
  935. Suppression of endothelial-to-mesenchymal transition by SIRT (Sirtuin) 3 alleviated the development of hypertensive renal injury
  936. Sulfhydrated sirtuin-1 increasing its deacetylation activity is an essential epigenetics mechanism of anti-atherogenesis by hydrogen sulfide
  937. Role of hydrogen sulfide in NRF2-and sirtuin-dependent maintenance of cellular redox balance
  938. Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features
  939. Vascular smooth muscle sirtuin-1 protects against diet-induced aortic stiffness
  940. Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: the role of the ERK-CREB pathway and Bnip3-mediated mitophagy
  941. Sirtuin 1 suppresses mitochondrial dysfunction of ischemic mouse livers in a mitofusin 2-dependent manner
  942. A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions
  943. Sirtuin 3: A Janus face in cancer
  944. Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats
  945. Telomere dysfunction induces sirtuin repression that drives telomere-dependent disease
  946. Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of Sirtuin 1
  947. Age-associated sirtuin 1 reduction in vascular smooth muscle links vascular senescence and inflammation to abdominal aortic aneurysm
  948. Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration
  949. Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration
  950. Sirtuin 2 enhances allergic asthmatic inflammation
  951. Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel
  952. Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis
  953. Myricanol rescues dexamethasone‐induced muscle dysfunction via a sirtuin 1‐dependent mechanism
  954. Sirtuin lipoamidase activity is conserved in bacteria as a regulator of metabolic enzyme complexes
  955. Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis
  956. Targeting Sirtuin-1 prolongs murine renal allograft survival and function
  957. Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity
  958. Nicotinamide mononucleotide, an NAD+ precursor, rescues age-associated susceptibility to AKI in a sirtuin 1–dependent manner
  959. Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation
  960. Sirtuin 3 deficiency does not impede digit regeneration in mice
  961. Adipose tissue, but not skeletal muscle, sirtuin 1 expression is decreased in obesity and related to insulin sensitivity
  962. Amyloid-β increases tau by mediating sirtuin 3 in Alzheimer’s disease
  963. Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance
  964. Regulatory effects of NAD+ metabolic pathways on sirtuin activity
  965. Sirtuin-1 activation controls tumor growth by impeding Th17 differentiation via STAT3 deacetylation
  966. The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis
  967. Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer
  968. Suppression of Sirtuin-1 increases IL-6 expression by activation of the Akt pathway during allergic asthma
  969. Sirtuin‐1 in immunotherapy: A Janus‐headed target
  970. Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis
  971. Decreased sirtuin 4 expression is associated with poor prognosis in patients with invasive breast cancer
  972. Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells
  973. Sirtuin 5 regulates proximal tubule fatty acid oxidation to protect against AKI
  974. Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells
  975. Sirtuin 5 as a novel target to blunt blood–brain barrier damage induced by cerebral ischemia/reperfusion injury
  976. A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma
  977. Could sirtuin activities modify ALS onset and progression?
  978. Sirtuin 2 regulates microvascular inflammation during sepsis
  979. Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2
  980. Yeast sirtuin family members maintain transcription homeostasis to ensure genome stability
  981. Serum Sirtuin 1, 3 and 6 levels in acute myocardial infarction patients
  982. A prospective compound screening contest identified broader inhibitors for sirtuin 1
  983. Aging promotes sirtuin 3–dependent cartilage superoxide dismutase 2 acetylation and osteoarthritis
  984. Cardioprotective effect of a moderate and prolonged exercise training involves sirtuin pathway
  985. Sirtuin-2 protects neural cells from oxidative stress and is elevated in neurodegeneration
  986. Sirtuin inhibitors are broadly antiviral against arboviruses
  987. Distinct role of Sirtuin 1 (SIRT1) and Sirtuin 2 (SIRT2) in inhibiting cargo-loading and release of extracellular vesicles
  988. Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice
  989. The mechanism of diabetic retinopathy pathogenesis unifying key lipid regulators, sirtuin 1 and liver X receptor
  990. Management of diabetic nephropathy: the role of sirtuin-1
  991. Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling
  992. Intestinal epithelial sirtuin 1 regulates intestinal inflammation during aging in mice by altering the intestinal microbiota
  993. Sirtuin 2 deficiency increases bacterial phagocytosis by macrophages and protects from chronic staphylococcal infection
  994. Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cells
  995. Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation: role in pulmonary arterial hypertension
  996. Sirtuin 1 attenuates inflammation and hepatocellular damage in liver transplant ischemia/reperfusion: from mouse to human
  997. Resveratrol protects against TNF-α-induced injury in human umbilical endothelial cells through promoting sirtuin-1-induced repression of NF-KB and p38 …
  998. Activation of sirtuin 1 attenuates high glucose-induced neuronal apoptosis by deacetylating p53
  999. Is there any relationship between serum sirtuin-1 level and neutrophil-lymphocyte ratio in hyperemesis gravidarum?
  1000. Phenotype of vascular smooth muscle cells (VSMCs) is regulated by miR-29b by targeting sirtuin 1
  1001. Sirtuin 2 aggravates postischemic liver injury by deacetylating mitogen‐activated protein kinase phosphatase‐1
  1002. Sirtuin 3 attenuates amyloid-β induced neuronal hypometabolism
  1003. MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4
  1004. Sirtuin 3 silencing impairs mitochondrial biogenesis and metabolism in colon cancer cells
  1005. Identification of sirtuin 1 as a promising therapeutic target for hypertrophic scars
  1006. Sirtuin 6 overexpression relieves sepsis-induced acute kidney injury by promoting autophagy
  1007. Chemically induced degradation of sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals)
  1008. Decreased sirtuin deacetylase activity in LRRK2 G2019S iPSC-derived dopaminergic neurons
  1009. Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity
  1010. Pro-proliferative function of mitochondrial sirtuin deacetylase SIRT3 in human melanoma
  1011. Trimetazidine prevents macrophage‐mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1
  1012. Fine‐tuning of sirtuin 1 expression is essential to protect the liver from cholestatic liver disease
  1013. Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients
  1014. Deep vein thrombosis is modulated by inflammation regulated via sirtuin 1/NF-κB signalling pathway in a rat model
  1015. Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells
  1016. KDM2B is a histone H3K79 demethylase and induces transcriptional repression via sirtuin‐1‐mediated chromatin silencing
  1017. Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll‐like receptor 4 signaling pathway
  1018. Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis
  1019. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer’s disease mouse model
  1020. Impact of sirtuin-1 expression on H3K56 acetylation and oxidative stress: a double-blind randomized controlled trial with resveratrol supplementation
  1021. Thienopyrimidinone based sirtuin-2 (SIRT2)-selective inhibitors bind in the ligand induced selectivity pocket
  1022. Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts
  1023. Nicotinamide N‑methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1
  1024. Sirtuin 2 mutations in human cancers impair its function in genome maintenance
  1025. Proposed tandem effect of physical activity and sirtuin 1 and 3 activation in regulating glucose homeostasis
  1026. Mitochondrial sirtuin 4 resolves immune tolerance in monocytes by rebalancing glycolysis and glucose oxidation homeostasis
  1027. Melatonin modulates the microenvironment of glioblastoma multiforme by targeting sirtuin 1
  1028. Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and-independent mechanisms
  1029. Role of beta-adrenergic receptors and sirtuin signaling in the heart during aging, heart failure, and adaptation to stress
  1030. Loss of NAD-dependent protein deacetylase sirtuin-2 alters mitochondrial protein acetylation and dysregulates mitophagy
  1031. Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3
  1032. Mitochondrial dynamics is linked to longevity and protects from end-organ injury: the emerging role of sirtuin 3
  1033. Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium
  1034. Sirtuin 1-dependent resveratrol cytotoxicity and pro-differentiation activity on breast cancer cells
  1035. The emerging role of sirtuin 1 in cellular metabolism, diabetes mellitus, diabetic kidney disease and hypertension
  1036. Exogenous hydrogen sulfide supplement attenuates isoproterenol-induced myocardial hypertrophy in a sirtuin 3-dependent manner
  1037. Age-related changes in sirtuin 7 expression in calorie-restricted and refed rats
  1038. … of peptide-based sirtuin defatty-acylase inhibitors identified by the fluorescence probe, SFP3, that can efficiently measure defatty-acylase activity of sirtuin
  1039. Mitochondrial function, metabolic regulation, and human disease viewed through the prism of sirtuin 4 (SIRT4) functions
  1040. Accurate quantification of site-specific acetylation stoichiometry reveals the impact of sirtuin deacetylase CobB on the E. coli acetylome
  1041. … heart from contractile dysfunction mediated through the inhibition of endoplasmic reticulum stress-mediated apoptosis in cardiac-specific Sirtuin 1 knockout mouse …
  1042. Sirtuin 3 attenuates neuroinflammation-induced apoptosis in BV-2 microglia
  1043. Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma
  1044. Serum concentrations and gene expression of sirtuin 1 in healthy and slightly overweight subjects after caloric restriction or resveratrol supplementation: A …
  1045. Dexmedetomidine attenuation of renal ischaemia-reperfusion injury requires sirtuin 3 activation
  1046. A novel sirtuin-3 inhibitor, LC-0296, inhibits cell survival and proliferation, and promotes apoptosis of head and neck cancer cells
  1047. Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ
  1048. Biophysical interaction of resveratrol with sirtuin pathway: Significance in Alzheimer’s disease
  1049. Curcumin elevates sirtuin level but does not postpone in vitro senescence of human cells building the vasculature
  1050. Sirtuin A regulates secondary metabolite production by Aspergillus nidulans
  1051. Adherence to the mediterranean diet and circulating levels of sirtuin 4 in obese patients: a novel association
  1052. Sirtuin 6 prevents matrix degradation through inhibition of the NF-κB pathway in intervertebral disc degeneration
  1053. Cysteine cathepsins control hepatic NF-κ B-dependent inflammation via sirtuin-1 regulation
  1054. Myeloid sirtuin 6 deficiency causes insulin resistance in high-fat diet–fed mice by eliciting macrophage polarization toward an M1 phenotype
  1055. Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1
  1056. Icariin protects cardiomyocytes against ischaemia/reperfusion injury by attenuating sirtuin 1‐dependent mitochondrial oxidative damage
  1057. Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samples
  1058. Heme oxygenase‐1 regulates sirtuin‐1–autophagy pathway in liver transplantation: From mouse to human
  1059. Sirtuin 7 deficiency ameliorates cisplatin-induced acute kidney injury through regulation of the inflammatory response
  1060. Apolipoprotein E regulates mitochondrial function through the PGC-1α-sirtuin 3 pathway
  1061. Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid–fed mouse model of cholestasis
  1062. Sirtuin 5 is anti-apoptotic and anti-oxidative in cultured SH-EP neuroblastoma cells
  1063. Hepatocyte‐specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up‐regulation of Bach1, an Nrf2 repressor
  1064. Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections
  1065. AMP-activated protein kinase and sirtuin 1 coregulation of cortactin contributes to endothelial function
  1066. The sirtuin 6 prevents angiotensin II-mediated myocardial fibrosis and injury by targeting AMPK-ACE2 signaling
  1067. Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice
  1068. TRPV1 activation counters diet-induced obesity through sirtuin-1 activation and PRDM-16 deacetylation in brown adipose tissue
  1069. High glucose‐induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects
  1070. Sirtuin 7 plays an oncogenic role in human osteosarcoma via downregulating CDC4 expression
  1071. Sirtuin-1 ameliorates cadmium-induced endoplasmic reticulum stress and pyroptosis through XBP-1s deacetylation in human renal tubular epithelial cells
  1072. Sirtuin 3-mediated pyruvate dehydrogenase activity determines brown adipocytes phenotype under high-salt conditions
  1073. Sirtuin 1 alleviates diabetic neuropathic pain by regulating synaptic plasticity of spinal dorsal horn neurons
  1074. Targeting anti‐aging protein sirtuin (Sirt) in the diagnosis of idiopathic pulmonary fibrosis
  1075. A conserved mechanism of sirtuin signalling through steroid hormone receptors
  1076. Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1β axis in mice
  1077. Facilitation of liver cancer SMCC7721 cell aging by sirtuin 4 via inhibiting JAK2/STAT3 signal pathway
  1078. Activation of sirtuin 3 by silybin attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury
  1079. Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site,“selectivity pocket” and NAD+-binding site
  1080. Inhibition of sirtuin 1 deacetylase by miR-211-5p provides a mechanism for the induction of cell death in breast cancer cells
  1081. Sirtuin 1 activation attenuates cardiac fibrosis in a rodent pressure overload model by modifying Smad2/3 transactivation
  1082. Aromatase acetylation patterns and altered activity in response to sirtuin inhibition
  1083. Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC-1ɑ-SOD2-mediated regulation of mitochondrial function
  1084. Comparison of sirtuin 3 levels in ALS and Huntington’s disease—differential effects in human tissue samples vs. transgenic mouse models
  1085. Novel lysine-based thioureas as mechanism-based inhibitors of Sirtuin 2 (SIRT2) with anticancer activity in a colorectal cancer murine model
  1086. Sirtuin 1 activation reduces transforming growth factor-β1–induced fibrogenesis and affords organ protection in a model of progressive, experimental kidney …
  1087. Heterogeneous nuclear ribonucleoprotein F stimulates sirtuin-1 gene expression and attenuates nephropathy progression in diabetic mice
  1088. Protective effects of dioscin against cisplatin‐induced nephrotoxicity via the microRNA‐34a/sirtuin 1 signalling pathway
  1089. miR-34a promotes vascular smooth muscle cell calcification by downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase)
  1090. Prolactin protects retinal pigment epithelium by inhibiting sirtuin 2-dependent cell death
  1091. SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis
  1092. Sirtuin 1 and 7 mediate resveratrol-induced recovery from hyper-anxiety in high-fructose-fed prediabetic rats
  1093. miR‐221 negatively regulates inflammation and insulin sensitivity in white adipose tissue by repression of sirtuin‐1 (SIRT1)
  1094. Sirtuin 2 inhibition improves cognitive performance and acts on amyloid-β protein precursor processing in two Alzheimer’s disease mouse models
  1095. Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3β/β-catenin pathway
  1096. MiR-34a/sirtuin-1/foxo3a is involved in genistein protecting against ox-LDL-induced oxidative damage in HUVECs
  1097. Renalase attenuates mitochondrial fission in cisplatin-induced acute kidney injury via modulating sirtuin-3
  1098. Sirtuin 6 in preosteoclasts suppresses age-and estrogen deficiency-related bone loss by stabilizing estrogen receptor α
  1099. Sirtuin 2 isoform 1 enhances hepatitis B virus RNA transcription and DNA synthesis through the AKT/GSK-3β/β-catenin signaling pathway
  1100. Fenofibrate inhibits atrial metabolic remodelling in atrial fibrillation through PPAR‐α/sirtuin 1/PGC‐1α pathway
  1101. Aging-related correlation between serum sirtuin 1 activities and basal metabolic rate in women, but not in men
  1102. Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes
  1103. SIRTUIN 3, ENDOTHELIAL METABOLIC REPROGRAMMING AND HEART FAILURE WITH PRESERVED EJECTION FRACTION
  1104. Sirtuin‐1/mitochondrial ribosomal protein S5 axis enhances the metabolic flexibility of liver cancer stem cells
  1105. Endothelial sirtuin 1 inactivation enhances capillary rarefaction and fibrosis following kidney injury through Notch activation
  1106. Defective sirtuin-1 increases IL-4 expression through acetylation of GATA-3 in patients with severe asthma
  1107. Activation of sirtuin 3 and maintenance of mitochondrial integrity by N-acetylcysteine protects against bisphenol A-induced kidney and liver toxicity in rats
  1108. Sirtuin 3 deficiency aggravates contrast-induced acute kidney injury
  1109. Inhibition of mitochondrial oxidative damage improves reendothelialization capacity of endothelial progenitor cells via SIRT3 (Sirtuin 3)-enhanced SOD2 (Superoxide …
  1110. Inhibition of Sirtuin 6 induces neuroblastoma differentiation
  1111. Activators of sirtuin-1 and their involvement in cardioprotection
  1112. X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells
  1113. Sirtuin 1 stimulation attenuates ischemic liver injury and enhances mitochondrial recovery and autophagy
  1114. Sirtuin 1 (Sirt1) overexpression in BaF3 cells contributes to cell proliferation promotion, apoptosis resistance and pro-inflammatory cytokine production
  1115. Resveratrol inhibits doxorubicin‑induced cardiotoxicity via sirtuin 1 activation in H9c2 cardiomyocytes
  1116. Sirtuin 1 represses PKC‐ζ activity through regulating interplay of acetylation and phosphorylation in cardiac hypertrophy
  1117. Sirtuin-3 promotes adipogenesis, osteoclastogenesis, and bone loss in aging male mice
  1118. Sirtuin 3 silencing improves oxaliplatin efficacy through acetylation of MnSOD in colon cancer
  1119. Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy
  1120. Peroxynitrite-mediated SIRT (Sirtuin)-1 inactivation contributes to nicotine-induced arterial stiffness in mice
  1121. microRNA-526b servers as a prognostic factor and exhibits tumor suppressive property by targeting Sirtuin 7 in hepatocellular carcinoma
  1122. Sirtuin 5 deficiency does not compromise innate immune responses to bacterial infections
  1123. Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway
  1124. Melatonin modulation of sirtuin-1 attenuates liver injury in a hypercholesterolemic mouse model
  1125. MicroRNA-34a targets sirtuin 1 and leads to diabetes-induced testicular apoptotic cell death
  1126. Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner
  1127. MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1)
  1128. Comparison of calorie-restricted diet and resveratrol supplementation on anthropometric indices, metabolic parameters, and serum sirtuin-1 levels in patients with …
  1129. Sirtuin 3 rescues neurons through the stabilisation of mitochondrial biogenetics in the virally-expressing mutant α-synuclein rat model of parkinsonism
  1130. The prognostic and Clinicopathological roles of Sirtuin-3 in various cancers
  1131. Mitochondrial metabolism regulates microtubule acetylome and autophagy trough sirtuin-2: impact for Parkinson’s disease
  1132. NAD+ dependent deacetylase Sirtuin 5 rescues the innate inflammatory response of endotoxin tolerant macrophages by promoting acetylation of p65
  1133. Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: a double-blind …
  1134. Melatonin protective effect against amyloid β-induced neurotoxicity mediated by mitochondrial biogenesis; involvement of hippocampal Sirtuin-1 signaling pathway
  1135. Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy
  1136. Sirtuin 1 regulates mitochondrial biogenesis and provides an endogenous neuroprotective mechanism against seizure-induced neuronal cell death in the …
  1137. Carnosol-mediated Sirtuin 1 activation inhibits Enhancer of Zeste Homolog 2 to attenuate liver fibrosis
  1138. Neuroprotective effect of salidroside against central nervous system inflammation‐induced cognitive deficits: a pivotal role of sirtuin 1‐dependent N rf‐2/HO‐1/NF‐κ B …
  1139. Melatonin reverses H2O2‐induced senescence in SH‐SY5Y cells by enhancing autophagy via sirtuin 1 deacetylation of the RelA/p65 subunit of NF‐κB
  1140. Lysine acetylation stoichiometry and proteomics analyses reveal pathways regulated by sirtuin 1 in human cells
  1141. Prostaglandin E2 down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity–breast cancer connection
  1142. The polyphenol resveratrol promotes skeletal growth in mice through a sirtuin 1‐bone morphogenic protein 2 longevity axis
  1143. Potential suppression of the high glucose and insulin-induced retinal neovascularization by Sirtuin 3 in the human retinal endothelial cells
  1144. Myeloid cell-specific sirtuin 6 deficiency delays wound healing in mice by modulating inflammation and macrophage phenotypes
  1145. Structure–Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni (SmSirt2)
  1146. Fibrogenic secretome of sirtuin 1-deficient endothelial cells: Wnt, notch and glycocalyx rheostat
  1147. Sirtuin inhibitors: An overview from medicinal chemistry perspective
  1148. Development of substrate‐derived sirtuin inhibitors with potential anticancer activity
  1149. Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway
  1150. Sirtuin 2 expression suppresses oxidative stress and senescence of nucleus pulposus cells through inhibition of the p53/p21 pathway
  1151. Ketones improves Apolipoprotein E4-related memory deficiency via sirtuin 3
  1152. Sirtuin 3 suppresses the formation of renal calcium oxalate crystals through promoting M2 polarization of macrophages
  1153. Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy
  1154. Contrasting sirtuin and poly (ADP‐ribose) polymerase activities of selected 2, 4, 6‐trisubstituted benzimidazoles
  1155. Oncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition
  1156. Hyperacetylation of cardiac mitochondrial proteins is associated with metabolic impairment and sirtuin downregulation after chronic total body irradiation of ApoE …
  1157. Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor‐β1/Smad2 and nuclear factor‐κB signaling pathways in human fetal lung …
  1158. Structure-based identification of novel sirtuin inhibitors against triple negative breast cancer: An in silico and in vitro study
  1159. Cross-talk between sirtuin 1 and the proinflammatory mediator high-mobility group box-1 in the regulation of blood-retinal barrier breakdown in diabetic retinopathy
  1160. Ablation of carotenoid cleavage enzymes (BCO1 and BCO2) induced hepatic steatosis by altering the farnesoid X receptor/miR-34a/sirtuin 1 pathway
  1161. KH-TFMDI, a novel sirtuin inhibitor, alters the cytoskeleton and mitochondrial metabolism promoting cell death in Leishmania amazonensis
  1162. MicroRNA 199a is downregulated in patients after coronary artery bypass graft surgery and is associated with increased levels of sirtuin 1 (SIRT 1) protein and …
  1163. Regulation of autophagy by AMP-activated protein kinase/sirtuin 1 pathway reduces spinal cord neurons damage
  1164. Preventing muscle wasting by osteoporosis drug alendronate in vitro and in myopathy models via sirtuin‐3 down‐regulation
  1165. … factor serves a pivotal role in the regulation of radiation-induced cardiac senescencethrough rebalancing the microRNA-34a/sirtuin 1 signaling pathway
  1166. Nicotinic ACh receptor α7 inhibits PDGF‐induced migration of vascular smooth muscle cells by activating mitochondrial deacetylase sirtuin 3
  1167. Sirtuin-dependent reversible lysine acetylation of glutamine synthetases reveals an autofeedback loop in nitrogen metabolism
  1168. Diisononyl phthalate differentially affects sirtuin expression in the HepG2 cell line
  1169. Sirtuin-1 (SIRT1) stimulates growth-plate chondrogenesis by attenuating the PERK–eIF-2α–CHOP pathway in the unfolded protein response
  1170. Highly Efficient Synthesis of Spirooxindole, Spiroacenaphthylene and Bisbenzo [b] pyran Derivatives and Evaluation of Their Inhibitory Activity against Sirtuin 2
  1171. Sirtuin 7 promotes glioma proliferation and invasion through activation of the ERK/STAT3 signaling pathway
  1172. Heat shock gene Sirtuin 1 regulates post-prandial lipid metabolism with relevance to nutrition and appetite regulation in diabetes
  1173. Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice
  1174. Mitochondrial intermediate peptidase is a novel regulator of sirtuin‐3 activation by caloric restriction
  1175. Visualization of sirtuin 4 distribution between mitochondria and the nucleus, based on bimolecular fluorescence self-complementation
  1176. Sirtuin 3 inhibition induces mitochondrial stress in tongue cancer by targeting mitochondrial fission and the JNK-Fis1 biological axis
  1177. Hydroxytyrosol attenuates LPS-induced acute lung injury in mice by regulating autophagy and sirtuin expression
  1178. Activation of sirtuin 1 by catalpol-induced down-regulation of microRNA-132 attenuates endoplasmic reticulum stress in colitis
  1179. Sirtuin 1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions
  1180. Sirtuin 1-mediated deacetylation of XPA DNA repair protein enhances its interaction with ATR protein and promotes cAMP-induced DNA repair of UV damage
  1181. Sirtuin 1 knockdown inhibits glioma cell proliferation and potentiates temozolomide toxicity via facilitation of reactive oxygen species generation
  1182. Nerve growth factor upregulates sirtuin 1 expression in cholestasis: a potential therapeutic target
  1183. Sirtuin 1 and autophagy attenuate cisplatin-induced hair cell death in the mouse cochlea and zebrafish lateral line
  1184. Sirtuin signaling controls mitochondrial function in glycogen storage disease type Ia
  1185. Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-β1/Smad3 signaling
  1186. A Toxin Involved in Salmonella Persistence Regulates Its Activity by Acetylating Its Cognate Antitoxin, a Modification Reversed by CobB Sirtuin Deacetylase
  1187. Sirtuin 1 promotes deacetylation of Oct4 and maintenance of naive pluripotency
  1188. Serum and follicular fluid levels of sirtuin 1, sirtuin 6, and resveratrol in women undergoing in vitro fertilization: an observational, clinical study
  1189. Urinary levels of sirtuin-1 associated with disease activity in lupus nephritis
  1190. A potent and selective small molecule inhibitor of sirtuin 1 promotes differentiation of pluripotent P19 cells into functional neurons
  1191. Identification of bichalcones as sirtuin inhibitors by virtual screening and in vitro testing
  1192. Polydatin improves the developmental competence of bovine embryos in vitro via induction of sirtuin 1 (Sirt1)
  1193. Effects of resveratrol, exercises and their combination on Farnesoid X receptor, Liver X receptor and Sirtuin 1 gene expression and apoptosis in the liver of …
  1194. Association between sirtuin 1 gene rs10997870 polymorphism and suicide behaviors in bipolar disorder
  1195. Tissue-specific gene expression and fasting regulation of sirtuin family in gilthead sea bream (Sparus aurata)
  1196. Alterations in fatty acid metabolism and sirtuin signaling characterize early type‐2 diabetic hearts of fructose‐fed rats
  1197. Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells
  1198. Sirtuin 1 inhibits TNF-α-mediated osteoclastogenesis of bone marrow-derived macrophages through both ROS generation and TRPV1 activation
  1199. A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease
  1200. New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2
  1201. Identification of diketopiperazine-containing 2-anilinobenzamides as potent sirtuin 2 (SIRT2)-Selective inhibitors targeting the “selectivity pocket”, substrate-binding …
  1202. Lowered expression of microRNA-125a-5p in human hepatocellular carcinoma and up-regulation of its oncogenic targets sirtuin-7, matrix metalloproteinase …
  1203. Sirtuin 3 mediates tau deacetylation
  1204. MicroRNA-519d inhibits proliferation and induces apoptosis of human hypertrophic scar fibroblasts through targeting Sirtuin 7
  1205. Resveratrol directly affects ovarian cell sirtuin, proliferation, apoptosis, hormone release and response to follicle-stimulating hormone (FSH) and insulin-like growth …
  1206. Sirtuin 7–mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity
  1207. Sirtuin 4 Depletion Promotes Hepatocellular Carcinoma Tumorigenesis Through Regulating Adenosine‐Monophosphate–Activated Protein Kinase Alpha/Mammalian …
  1208. Nicotinamide phosphoribosyltransferase regulates cocaine reward through Sirtuin 1
  1209. Sirtuin-1 controls poly (I: C)–dependent matrix metalloproteinase 9 activation in primary human nasal epithelial cells
  1210. Sirtuin-3 (SIRT3) protects pancreatic β-cells from endoplasmic reticulum (ER) stress-induced apoptosis and dysfunction
  1211. Toxicarioside O induces protective autophagy in a sirtuin-1-dependent manner in colorectal cancer cells
  1212. The tubulin deacetylase sirtuin-2 regulates neuronal differentiation through the ERK/CREB signaling pathway
  1213. Betalain-and betacyanin-rich supplements’ impacts on the PBMC SIRT1 and LOX1 genes expression and Sirtuin-1 protein levels in coronary artery disease patients: A …
  1214. Tetrahydroindoles as Multipurpose Screening Compounds and Novel Sirtuin Inhibitors
  1215. The plasticizer BBP selectively inhibits epigenetic regulator sirtuin during differentiation of C3H10T1/2 stem cell line
  1216. Three‐Component Aminoalkylations Yielding Dihydronaphthoxazine‐Based Sirtuin Inhibitors: Scaffold Modification and Exploration of Space for Polar Side‐Chains
  1217. Effects of resveratrol postconditioning on cerebral ischemia in mice: role of the sirtuin-1 pathway
  1218. Shelterin telomere protection protein 1 reduction causes telomere attrition and cellular senescence via sirtuin 1 deacetylase in chronic obstructive pulmonary disease
  1219. Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4
  1220. Human sirtuin 2 localization, transient interactions, and impact on the proteome point to its role in intracellular trafficking
  1221. Sirtuin‑1 protects hair follicle stem cells from TNFα-mediated inflammatory stress via activating the MAPK-ERK-Mfn2 pathway
  1222. Structure‐based discovery of new selective small‐molecule sirtuin 5 inhibitors
  1223. Simple Nε-thioacetyl-lysine-containing cyclic peptides exhibiting highly potent sirtuin inhibition
  1224. Enzymatic and biological characterization of novel sirtuin modulators against cancer
  1225. Sirtuin 6 Modulates Hypoxia-Induced Autophagy in Nasal Polyp Fibroblasts via Inhibition of Glycolysis
  1226. Anticancer activities of a benzimidazole compound through sirtuin inhibition in colorectal cancer
  1227. Chemical probes in sirtuin research
  1228. Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3β/BCL2-associated X protein-dependent apoptotic pathway
  1229. A low-salt diet increases the expression of renal sirtuin 1 through activation of the ghrelin receptor in rats
  1230. A Fluorescent Probe for Imaging Sirtuin Activity in Living Cells, Based on One‐Step Cleavage of the Dabcyl Quencher
  1231. Peroxisome proliferator-activated receptor-γ coactivator-1α inhibits vascular calcification through sirtuin 3-mediated reduction of mitochondrial oxidative stress
  1232. Protective effect of tyrosol and S-adenosylmethionine against ethanol-induced oxidative stress of Hepg2 cells involves sirtuin 1, P53 and Erk1/2 signaling
  1233. miRNA regulation of Sirtuin‑1 expression in human astrocytoma
  1234. Sirtuin 1 mediates the actions of peroxisome proliferator-activated receptor δ on the oxidized low-density lipoprotein–triggered migration and proliferation of vascular …
  1235. … attenuates lipopolysaccharide-induced depressive-like behavior through the brain-derived neurotrophic factor/tropomyosin-related kinase B and sirtuin type 1/nuclear …
  1236. Overexpression of sirtuin 6 suppresses allergic airway inflammation through deacetylation of GATA3
  1237. The effects of green cardamom supplementation on blood glucose, lipids profile, oxidative stress, sirtuin-1 and irisin in type 2 diabetic patients: a study …
  1238. Reduced sirtuin 1/adenosine monophosphate‐activated protein kinase in amyotrophic lateral sclerosis patient‐derived mesenchymal stem cells can be restored by …
  1239. Molecular evolutionary patterns of NAD+/Sirtuin aging signaling pathway across taxa
  1240. The preconditioning of berberine suppresses hydrogen peroxide-induced premature senescence via regulation of sirtuin 1
  1241. Autophagy in ischemic livers: a critical role of sirtuin 1/mitofusin 2 axis in autophagy induction
  1242. Adipose sirtuin 6 drives macrophage polarization toward M2 through IL-4 production and maintains systemic insulin sensitivity in mice and humans
  1243. Endothelial progenitor cells from aged subjects display decreased expression of sirtuin 1, angiogenic functions, and increased senescence
  1244. Expression of Leptin and Sirtuin-1 is associated with poor prognosis in patients with osteosarcoma
  1245. Resveratrol protects against cadmium chloride‐induced hippocampal neurotoxicity by inhibiting ER stress and GAAD 153 and activating sirtuin 1/AMPK/Akt
  1246. Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASH
  1247. … Eicosapentaenoic Acid Feeding Decreases Placental Lipid Deposition and Improves the Homeostasis of Oxidative Stress Through a Sirtuin‐1 (SIRT1) Independent …
  1248. Sirtuin inhibitors, EX527 and AGK2, suppress cell migration by inhibiting HSF1 protein stability
  1249. … and sulindac inhibit TGF-β1-induced epithelial-mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1
  1250. Azologization and repurposing of a hetero-stilbene-based kinase inhibitor: towards the design of photoswitchable sirtuin inhibitors
  1251. Tremella polysaccharides inhibit cellular apoptosis and autophagy induced by Pseudomonas aeruginosa lipopolysaccharide in A549 cells through sirtuin 1 …
  1252. Catching Sirtuin-2 intermediates one structure at the time
  1253. Carbon monoxide ameliorates hepatic ischemia/reperfusion injury via sirtuin 1‐mediated deacetylation of high‐mobility group box 1 in rats
  1254. Sinomenine induces G1-phase cell cycle arrest and apoptosis in malignant glioma cells via downregulation of sirtuin 1 and induction of p53 acetylation
  1255. A label-free Sirtuin 1 assay based on droplet-electrospray ionization mass spectrometry
  1256. Induction of nuclear enlargement and senescence by sirtuin inhibitors in glioblastoma cells
  1257. Erythromycin regulates cigarette smoke-induced proinflammatory mediator release through Sirtuin 1-nuclear factor κB axis in macrophages and mice lungs
  1258. CD36/sirtuin 1 axis impairment contributes to hepatic steatosis in ACE2-deficient mice
  1259. Human sirtuin 3 (SIRT3) deacetylates histone H3 lysine 56 to promote nonhomologous end joining repair
  1260. A one-step specific assay for continuous detection of sirtuin 2 activity
  1261. Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels
  1262. Sirtuin inhibition leads to autophagy and apoptosis in porcine preimplantation blastocysts
  1263. Gene expression of sirtuin-1 and endogenous secretory receptor for advanced glycation end products in healthy and slightly overweight subjects after caloric …
  1264. Loss of sirtuin 4 leads to elevated glucose-and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic …
  1265. Sirtuin 1 activator Srt1720 protects against organ injury induced by intestinal ischemia-reperfusion
  1266. Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding
  1267. Regulation of sirtuin 3-mediated deacetylation of cyclophilin D attenuated cognitive dysfunction induced by sepsis-associated encephalopathy in mice
  1268. Maternal eicosapentaenoic acid feeding promotes placental angiogenesis through a Sirtuin-1 independent inflammatory pathway
  1269. Structure of the sirtuin‐linked macrodomain SAV0325 from Staphylococcus aureus
  1270. Sirtuin 1-chromatin-binding dynamics points to a common mechanism regulating inflammatory targets in SIV infection and in the aging brain
  1271. Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity
  1272. Saccharomyces cerevisiae TORC1 controls histone acetylation by signaling through the Sit4/PP6 phosphatase to regulate sirtuin deacetylase nuclear accumulation
  1273. Sirtuin 3 (SIRT3) regulates α-smooth muscle actin (α-SMA) production through the succinate dehydrogenase-G protein-coupled receptor 91 (GPR91) pathway in …
  1274. Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma
  1275. MicroRNA-195 regulates metabolism in failing myocardium via alterations in sirtuin 3 expression and mitochondrial protein acetylation
  1276. Sirtuin 1 mediates hydrogen sulfide-induced cytoprotection effects in neonatal mouse cardiomyocytes
  1277. Effect of Sirtuin 1 inhibition on matrix metalloproteinase 2 and Forkhead box O3a expression in breast cancer cells
  1278. Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism
  1279. Sirtuin 4 regulates lipopolysaccharide mediated Leydig cell dysfunction
  1280. Association of sirtuin 1 gene polymorphisms with nephrolithiasis in Eastern chinese population
  1281. Sirtuin 6 suppresses hypoxia‐induced inflammatory response in human osteoblasts via inhibition of reactive oxygen species production and glycolysis—A therapeutic …
  1282. Attenuated SUMOylation of sirtuin 1 in premature neonates with bronchopulmonary dysplasia
  1283. Danhong Huayu Koufuye prevents venous thrombosis through antiinflammation via Sirtuin 1/NF-κB signaling pathway
  1284. Serum Sirtuin 1, 3 and 6 levels in acute myocardial infarction patients
  1285. Retracted: Downregulation of lncRNA TUG1 contributes to the development of sepsis‐associated acute kidney injury via regulating miR‐142‐3p/sirtuin 1 axis and …
  1286. Mechanism of osteogenic and adipogenic differentiation of tendon stem cells induced by sirtuin 1
  1287. Circular HDAC9/microRNA-138/Sirtuin-1 pathway mediates synaptic and amyloid precursor protein processing deficits in Alzheimer’s disease
  1288. Tip60-and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy
  1289. γ-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis
  1290. Sirtuin 1 reduces hyaluronan synthase 2 expression by inhibiting nuclear translocation of NF-κB and expression of the long-noncoding RNA HAS2–AS1
  1291. Effect of glucosamine on expression of type II collagen, matrix metalloproteinase and sirtuin genes in a human chondrocyte cell line
  1292. Improved mass spectrometry-based activity assay reveals oxidative and metabolic stress as sirtuin-1 regulators
  1293. Sirtuin 7 promotes 45S pre-rRNA cleavage at site 2 and determines the processing pathway
  1294. Resveratrol reduced liver damage after liver resection in a rat model by upregulating sirtuin 1 (SIRT1) and inhibiting the acetylation of high mobility group box …
  1295. Effect of statins on sirtuin 1 and endothelial nitric oxide synthase expression in young patients with a history of premature myocardial infarction
  1296. Sirtuin 2–mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I interferon responses
  1297. Natural alkaloid bouchardatine ameliorates metabolic disorders in high‐fat diet‐fed mice by stimulating the sirtuin 1/liver kinase B‐1/AMPK axis
  1298. Constitutive activation of NAD-dependent sirtuin 3 plays an important role in tumorigenesis of chromium (VI)-transformed cells
  1299. Effects of Sirtuin 1 on microglia in spinal cord injury: Involvement of Wnt/β-catenin signaling pathway
  1300. p53 inhibits the upregulation of sirtuin 1 expression induced by c‑Myc
  1301. 4′‐Bromo‐resveratrol, a dual Sirtuin‐1 and Sirtuin‐3 inhibitor, inhibits melanoma cell growth through mitochondrial metabolic reprogramming
  1302. Peroxisome proliferator-activated receptor α facilitates osteogenic differentiation in MC3T3-E1 cells via the sirtuin 1-dependent signaling pathway
  1303. Sirtuin 1 regulates matrix metalloproteinase-13 expression induced by Porphyromonas endodontalis lipopolysaccharide via targeting nuclear factor–κB in …
  1304. Sirtuin 3 promotes microglia migration by upregulating CX3CR1
  1305. Effect and mechanism of fuzhisan and donepezil on the sirtuin 1 pathway and amyloid precursor protein metabolism in PC12 cells
  1306. Exploration of the fluorescent properties and the modulated activities against sirtuin fluorogenic assays of chromenone-derived natural products
  1307. MicroRNA-506 is involved in regulation of the occurrence of lipopolysaccharides (LPS)-induced pulpitis by sirtuin 1 (SIRT1)
  1308. The NAD-dependent deacetylase sirtuin-1 regulates the expression of osteogenic transcriptional activator runt-related transcription factor 2 (Runx2) and production of …
  1309. Sirtuin‑7 knockdown inhibits the growth of endometrial cancer cells by inducing apoptosis via the NF‑κB signaling pathway
  1310. Inter-individual responses to sprint interval training, a pilot study investigating interactions with the sirtuin system
  1311. … protects human retinal pigment epithelial cells against hydrogen peroxide mediated oxidative stress, autophagy, and apoptosis through sirtuin 3 signal pathway
  1312. Hydroxytyrosol modulates the levels of microRNA-9 and its target sirtuin-1 thereby counteracting oxidative stress-induced chondrocyte death
  1313. Sirtuin 5 overexpression attenuates glucolipotoxicity-induced pancreatic β cells apoptosis and dysfunction
  1314. Studies of the binding of modest modulators of the human enzyme, sirtuin 6, by STD NMR
  1315. Identification of the binding site of chroman-4-one-based sirtuin 2-selective inhibitors using photoaffinity labeling in combination with tandem mass spectrometry
  1316. Resveratrol relieves Angiostrongylus cantonensis–Induced meningoencephalitis by activating sirtuin-1
  1317. The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing’s sarcoma cell line
  1318. Nobiletin alleviates palmitic acid‑induced NLRP3 inflammasome activation in a sirtuin 1‑dependent manner in AML‑12 cells
  1319. Expression profile of diabetes-related genes associated with leukocyte sirtuin 1 overexpression in gestational diabetes
  1320. Pinitol alleviates systemic inflammatory cytokines in human obesity by a mechanism involving unfolded protein response and sirtuin 1
  1321. Sirtuin 1 promotes the proliferation of C2C12 myoblast cells via the myostatin signaling pathway
  1322. Tubastatin A inhibits HDAC and Sirtuin activity rather than being a HDAC6-specific inhibitor in mouse oocytes
  1323. Sirtuin-6 preserves R-spondin-1 expression and increases resistance of intestinal epithelium to injury in mice
  1324. Effect of nutrient deprivation on the expression and the epigenetic signature of sirtuin genes
  1325. Ginsenoside Rg1 attenuates isoflurane/surgery-induced cognitive disorders and sirtuin 3 dysfunction
  1326. Cannabinoid‐1 Receptor Antagonism Improves Glycemic Control and Increases Energy Expenditure Through Sirtuin‐1/Mechanistic Target of Rapamycin Complex 2 …
  1327. A synthetic non-histone substrate to study substrate targeting by the Gcn5 HAT and sirtuin HDACs
  1328. The fungal metabolite eurochevalierine, a sequiterpene alkaloid, displays anti-cancer properties through selective sirtuin 1/2 inhibition
  1329. The involvement of sirtuin 1 and heme oxygenase 1 in the hepatoprotective effects of quercetin against carbon tetrachloride-induced sub-chronic liver toxicity in rats
  1330. Sirtuin 7 promotes colorectal carcinoma proliferation and invasion through the inhibition of E-cadherin
  1331. The role of Sirtuin 2 in the regulation of myogenesis
  1332. Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18-and sirtuin-1-independent pathways
  1333. Low serum level of sirtuin 1 predicts coronary atherosclerosis plaques during computed tomography angiography among an asymptomatic cohort
  1334. MicroRNA‐506 upregulation contributes to sirtuin 1 inhibition of osteoclastogenesis in bone marrow stromal cells induced by TNF‐α treatment
  1335. Sirtuin 6 mitigated LPS‐induced human umbilical vein endothelial cells inflammatory responses through modulating nuclear factor erythroid 2‐related factor 2
  1336. Negative regulation of Sirtuin 1 by AMP-activated protein kinase promotes metformin-induced senescence in hepatocellular carcinoma xenografts
  1337. Screening the impact of sirtuin inhibitors on inflammatory and innate immune responses of macrophages and in a mouse model of endotoxic shock
  1338. Effect of vitamin D supplementation in combination with weight loss diet on lipid profile and sirtuin 1 in obese subjects with vitamin D deficiency: a double blind …
  1339. Structural Modifications of Benzimidazoles via Multi‐Step Synthesis and Their Impact on Sirtuin‐Inhibitory Activity
  1340. Effects of Sirtuin 1 on the proliferation and osteoblastic differentiation of periodontal ligament stem cells and stem cells from apical papilla
  1341. The emerging role of the epigenetic enzyme Sirtuin-1 and high mobility group Box 1 in patients with diabetic foot ulceration
  1342. Treatment with the neurotoxic Aβ (25–35) peptide modulates the expression of neuroprotective factors Pin1, Sirtuin 1, and brain-derived neurotrophic factor in SH …
  1343. Diabetic complications within the context of aging: Nicotinamide adenine dinucleotide redox, insulin C‐peptide, sirtuin 1–liver kinase B1–adenosine monophosphate …
  1344. Insulin-Like Growth Factor-1–Mediated DNA Repair in Irradiated Salivary Glands Is Sirtuin-1 Dependent
  1345. Anesthetic preconditioning increases sirtuin 2 gene expression in a renal ischemia reperfusion injury model.
  1346. Novel tubular–glomerular interplay in diabetic kidney disease mediated by sirtuin 1, nicotinamide mononucleotide, and nicotinamide adenine dinucleotide …
  1347. Exosomal microRNA‐155‐5p from PDLSCs regulated Th17/Treg balance by targeting sirtuin‐1 in chronic periodontitis
  1348. QSAR studies on the human sirtuin 2 inhibition by non-covalent 7, 5, 2-anilinobenzamide derivatives
  1349. Update on the role of Sirtuin 3 in cell differentiation: A major metabolic target that can be pharmacologically controlled
  1350. Sirtuin 6 inhibits MWCNTs-induced epithelial-mesenchymal transition in human bronchial epithelial cells via inactivating TGF-β1/Smad2 signaling pathway
  1351. Sirtuin 6 mediated stem cell cardiomyogenesis on protein coated nanofibrous scaffolds
  1352. An NAD+-Dependent Sirtuin Depropionylase and Deacetylase (Sir2La) from the Probiotic Bacterium Lactobacillus acidophilus NCFM
  1353. High basolateral glucose increases sodium-glucose cotransporter 2 and reduces sirtuin-1 in renal tubules through glucose transporter-2 detection
  1354. De novo expression of transfected sirtuin 3 enhances susceptibility of human MCF-7 breast cancer cells to hyperoxia treatment
  1355. Sirtuin 6 attenuates Kaposi’s sarcoma-associated herpesvirus reactivation by suppressing ori-Lyt activity and expression of RTA
  1356. Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1
  1357. MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1
  1358. … mitochondrial function during doxorubicin-induced cardiotoxicity: A possible role for peroxisome proliferator-activated receptor gamma coactivator 1-alpha and sirtuin …
  1359. Sirtuin 6 (SIRT6) activity assays
  1360. A sirtuin activator and an anti-inflammatory molecule—multifaceted roles of adjudin and its potential applications for aging-related diseases
  1361. Mono-(2-ethylhexyl) phthalate aggravates inflammatory response via Sirtuin regulation and Inflammasome activation in RAW 264.7 cells
  1362. Edible Bird’s Nest prevents menopause-related memory and cognitive decline in rats via increased hippocampal Sirtuin-1 expression
  1363. Sirtuin 1 independent effects of resveratrol in INS-1E β-cells
  1364. Development of 1, 2, 4-oxadiazoles as potent and selective inhibitors of the human deacetylase sirtuin 2: structure–activity relationship, X-ray crystal structure, and …
  1365. Genistein ameliorated endothelial nitric oxidase synthase uncoupling by stimulating sirtuin-1 pathway in ox-LDL-injured HUVECs
  1366. Sirtuin-3 is expressed by enteric neurons but it does not play a major role in their regulation of oxidative stress
  1367. MicroRNA‐590‐3P suppresses cell survival and triggers breast cancer cell apoptosis via targeting sirtuin‐1 and deacetylation of p53
  1368. Changes in sirtuin 2 and sirtuin 3 mRNA expressions in rheumatoid arthritis
  1369. Sirtuin E is a fungal global transcriptional regulator that determines the transition from the primary growth to the stationary phase
  1370. Rational design of novel sirtuin 1 activators via structure-activity insights from application of QSAR modeling
  1371. Staphylococcus aureus modulates the activity of acetyl‐Coenzyme A synthetase (Acs) by sirtuin‐dependent reversible lysine acetylation
  1372. Knock-out of a mitochondrial sirtuin protects neurons from degeneration in Caenorhabditis elegans
  1373. MiR-299-3p functions as a tumor suppressor via targeting Sirtuin 5 in hepatocellular carcinoma
  1374. 2-Methoxyestradiol protects against ischemia/reperfusion injury in alcoholic fatty liver by enhancing sirtuin 1-mediated autophagy
  1375. Nicotinamide phosphoribosyltransferase contributes to cocaine addiction through sirtuin 1.
  1376. Lack of association between sirtuin gene variants and endometrial cancer
  1377. Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice
  1378. Downregulation of sirtuin 3 by palmitic acid increases the oxidative stress, impairment of mitochondrial function, and apoptosis in liver cells
  1379. Intrathecal injection of resveratrol attenuates burn injury pain by activating spinal sirtuin 1
  1380. Sirtuin 3 protects against urban particulate matter-induced autophagy in human bronchial epithelial cells
  1381. Tumor-associated NADH oxidase (tNOX)-NAD+-sirtuin 1 axis contributes to oxaliplatin-induced apoptosis of gastric cancer cells
  1382. Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells
  1383. Effect of sirtuin-1 on synaptic plasticity in nucleus accumbens in a rat model of heroin addiction
  1384. Potential role of sirtuin 1 in Müller glial cells in mice choroidal neovascularization
  1385. Sirtuin 7 is involved in the consolidation of fear memory in mice
  1386. … high glucose‑induced apoptosis, and suppresses reactive oxygen species production and proinflammatory cytokine secretion, through sirtuin 1 activation in …
  1387. Metabolic reprogramming by 3-iodothyronamine (T1AM): a new perspective to reverse obesity through co-regulation of sirtuin 4 and 6 expression
  1388. Epigallocatechin-3-gallate-rich green tea extract ameliorates fatty liver and weight gain in mice fed a high fat diet by activating the sirtuin 1 and AMP activating protein …
  1389. Potent sirtuin inhibition with 1, 2, 5-trisubstituted benzimidazoles
  1390. Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma.
  1391. Sirtuin modulation as novel neuroprotective strategy for Alzheimer’s disease
  1392. Adjudin synergizes with paclitaxel and inhibits cell growth and metastasis by regulating the sirtuin 3–Forkhead box O3a axis in human small‐cell lung cancer
  1393. Decreased expression of sirtuin 3 protein correlates with early stage chronic renal allograft dysfunction in a rat kidney model
  1394. Sirtuin activation as a therapeutic approach against inborn errors of metabolism
  1395. MicroRNA-320 enhances radiosensitivity of glioma through down-regulation of sirtuin type 1 by directly targeting forkhead box protein M1
  1396. Sirtuin-activating compounds (STACs) alleviate D-galactosamine/lipopolysaccharide-induced hepatotoxicity in rats: involvement of sirtuin 1 and heme …
  1397. Left ventricular hypertrophy is associated with increased sirtuin level in newly diagnosed hypertensive patients
  1398. BZD9L1 sirtuin inhibitor as a potential adjuvant for sensitization of colorectal cancer cells to 5-fluorouracil
  1399. MicroRNA‐351‐5p aggravates intestinal ischaemia/reperfusion injury through the targeting of MAPK13 and sirtuin‐6
  1400. Sirtuin Inhibitors and Activators
  1401. Characterizing sirtuin 3 deacetylase affinity for aldehyde dehydrogenase 2
  1402. MicroRNA-142-3p inhibits cell proliferation and chemoresistance in ovarian cancer via targeting sirtuin 1
  1403. Unconventional Secretion of Adipocyte Fatty Acid Binding Protein 4 Is Mediated By Autophagic Proteins in a Sirtuin-1–Dependent Manner
  1404. Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study
  1405. Serum microRNA-211 as a biomarker for diabetic retinopathy via modulating Sirtuin 1
  1406. Carnosic acid protects normal mouse hepatocytes against H2O2‐induced cytotoxicity via sirtuin 1‐mediated signaling
  1407. Sirtuin 1 steers anti-inflammatory effects in vascular smooth muscle cells: protection without burden?
  1408. Sirtuin 1 levels in recurrent implantation failure
  1409. Sirtuin 1 promotes hyperoxia-induced lung epithelial cell death independent of NF-E2–related factor 2 activation
  1410. MicroRNA-421 induces hepatic mitochondrial dysfunction in non-alcoholic fatty liver disease mice by inhibiting sirtuin 3
  1411. Neohesperidin exerts lipid-regulating effects in vitro and in vivo via fibroblast growth factor 21 and AMP-activated protein kinase/sirtuin type 1/peroxisome proliferator …
  1412. Phencynonate mediates antidepressant response by activating sirtuin 6-SOD2/Prdx6 pathway
  1413. MicroRNA‑217 is involved in the progression of atherosclerosis through regulating inflammatory responses by targeting sirtuin 1
  1414. MicroRNA106a regulates matrix metalloprotease 9 in a sirtuin‐1 dependent mechanism
  1415. A silver lining for 24-hydroxycholesterol in Alzheimer’s disease: the involvement of the neuroprotective enzyme sirtuin 1
  1416. Sirtuin 1 rs1467568 and rs7895833 in South African Indians with early-onset coronary artery disease
  1417. Simvastatin ameliorates ionizing radiation-induced apoptosis in the thymus by activating the AKT/sirtuin 1 pathway in mice
  1418. Sirtuin family members selectively regulate autophagy in osteosarcoma and mesothelioma cells in response to cellular stress
  1419. Discovery of 2-((4, 6-dimethylpyrimidin-2-yl) thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors
  1420. Carbohydrate metabolism and gene expression of sirtuin 1 in healthy subjects after Sacha inchi oil supplementation: a randomized trial
  1421. MicroRNA-1225-5p inhibits the development and progression of thyroid cancer via targeting sirtuin 3
  1422. Nicotinamide Suppresses the DNA Damage Sensitivity of Saccharomyces cerevisiae Independently of Sirtuin Deacetylases
  1423. Resveratrol inhibits parathyroid hormone-induced apoptosis in human aortic smooth muscle cells by upregulating sirtuin 1
  1424. The effect of methimazole-induced postnatal hypothyroidism on the retinal maturation and on the Sirtuin 2 level
  1425. A novel screening test for esophageal squamous cell carcinoma: sirtuin-3
  1426. Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer
  1427. Differences in sirtuin regulation in response to calorie restriction in Cryptococcus neoformans
  1428. Sporadic Gene Loss After Duplication Is Associated with Functional Divergence of Sirtuin Deacetylases Among Candida Yeast Species
  1429. Poly (ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity
  1430. Glutaredoxin-1 deficiency causes fatty liver and dyslipidemia by inhibiting sirtuin-1
  1431. The effect of Ramadan fasting on sirtuin and visfatin levels
  1432. Sirtuin inhibition and anti-cancer activities of ethyl 2-benzimidazole-5-carboxylate derivatives
  1433. The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver …
  1434. Receptor‐interacting Protein 140 represses Sirtuin 3 to facilitate hypertrophy, mitochondrial dysfunction and energy metabolic dysfunction in cardiomyocytes
  1435. Involvement of flavonoids from the leaves of carya cathayensis sarg. In sirtuin 1 expression in HUVEC senescence
  1436. Scalable and purification-free synthesis of a myristoylated fluorogenic sirtuin substrate
  1437. Protective effects of aspirin and vitamin C against corn syrup consumption-induced cardiac damage through sirtuin-1 and HIF-1a pathway
  1438. Sirtuin 1 and adenosine in brain disorder therapy
  1439. Dehomocysteinylation is catalysed by the sirtuin‐2‐like bacterial lysine deacetylase CobB
  1440. Impacts on sirtuin function and bioavailability of the dietary bioactive compound dihydrocoumarin
  1441. Rs12778366 single nucleotide polymorphism of Sirtuin 1 (SIRT1) and response to resveratrol supplementation in patients with type 2 diabetes mellitus
  1442. Selection of reference genes for miRNA quantitative PCR and its application in miR-34a/Sirtuin-1 mediated energy metabolism in Megalobrama amblycephala
  1443. Effect of eight weeks aerobic and combined training on serum levels of sirtuin 1 and PGC-1α in coronary artery bypass graft patients
  1444. Sirtuin type 1 signaling pathway mediates the effect of diosgenin on chondrocyte metabolisms in osteoarthritis
  1445. Sirtuin activation by small molecules
  1446. The mimics of Nε-acyl-lysine derived from cysteine as sirtuin inhibitors
  1447. β-hydroxybutyrate protects hepatocytes against endoplasmic reticulum stress in a sirtuin 1-independent manner
  1448. Hypothermic machine perfusion ameliorates inflammation during ischemia‑reperfusion injury via sirtuin‑1‑mediated deacetylation of nuclear factor‑κB p65 in …
  1449. Involvement of resveratrol and ω-3 polyunsaturated fatty acids on sirtuin 1 gene expression in THP1 cells
  1450. Metal-binding effects of sirtuin inhibitor sirtinol
  1451. Structure-based design and computational studies of sirtuin inhibitors
  1452. Browning of adipose tissue and sirtuin involvement
  1453. Increased malondialdehyde vs. reduced sirtuin 1 in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without …
  1454. Serum sirtuin 1 protein as a potential biomarker for type 2 diabetes: Increased expression of sirtuin 1 and the correlation with microRNAs
  1455. Downregulation of angiotensin type 1 receptor and nuclear factor-κB by sirtuin 1 contributes to renoprotection in unilateral ureteral obstruction
  1456. Exogenous neutrophil elastase enters bronchial epithelial cells and suppresses cigarette smoke extract–induced heme oxygenase-1 by cleaving sirtuin 1
  1457. … , 3, 3′-Dichlorobiphenyl-4-ol, Exposure Alters the Expression of Genes Governing Fatty Acid Metabolism in the Absence of Functional Sirtuin 3: Examining the …
  1458. 5-((3-Amidobenzyl) oxy) nicotinamides as Sirtuin 2 Inhibitors
  1459. Does education level protect us from rapid ageing? Sirtuin expression versus age and level of education
  1460. Adipocyte differentiation is regulated by mitochondrial trifunctional protein α-subunit via sirtuin 1
  1461. MiR-30a-5p accelerates adipogenesis by negatively regulating Sirtuin 1
  1462. Mitochondrial respiration in intact peripheral blood mononuclear cells and sirtuin 3 activity in patients with movement disorders
  1463. A Genome-Wide Screen with Nicotinamide to Identify Sirtuin-Dependent Pathways in Saccharomyces cerevisiae
  1464. A Possible Reason to Induce Acute Graft-vs.-Host Disease After Hematopoietic Stem Cell Transplantation: Lack of Sirtuin-1 in CD4+ T Cells
  1465. Differential expression of human n-alpha-acetyltransferase 40 (hnaa40), nicotinamide phosphoribosyltransferase (nampt) and sirtuin-1 (sirt-1) pathway in …
  1466. Differential expression of sirtuin 2 and adipocyte maturation restriction: an adaptation process during hypoxia in fish
  1467. MicroRNA‑3666 inhibits breast cancer cell proliferation by targeting sirtuin 7
  1468. miR-92a regulates the expression levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 3 via sirtuin 1 signaling in hydrogen peroxide …
  1469. High-mobility group nucleosome-binding protein 1 as endogenous ligand induces innate immune tolerance in a TLR4-Sirtuin-1 dependent manner in human …
  1470. Aberrant caspase activation in laminin-α2-deficient human myogenic cells is mediated by p53 and sirtuin activity
  1471. Sirtuin 1/soluble guanylyl cyclase: a nitric oxide-independent pathway to rescue ageing-induced vascular dysfunction
  1472. Sirtuin 6 promotes cell aging of myeloma cell line KM-HM_ (31) by via Hippo signal pathway
  1473. MicroRNA‑378b regulates α‑1‑type 1 collagen expression via sirtuin 6 interference
  1474. Expression and genotype-dependent catalytic activity of N-acetyltransferase 2 (NAT2) in human peripheral blood mononuclear cells and its modulation by Sirtuin 1
  1475. Cooperative binding of cinnamon polyphenols as activators of Sirtuin‐1 protein in the insulin signaling pathway
  1476. Hydrogen attenuated oxidized low‑density lipoprotein‑induced inflammation through the stimulation of autophagy via sirtuin 1
  1477. Cross-talk between Sirtuin 1 and high-mobility box 1 in steatotic liver graft preservation
  1478. Modulation of the Inflammatory Status of Macrophages and Their Paracrine Effect on the Sensitivity of Adipocytes to Insulin with Sirtuin and PPARγ Receptor Activators
  1479. Sirtuin 6 attenuates periapical lesion propagation by modulating hypoxia‐induced chemokine (C‐C motif) ligand 2 production in osteoblasts
  1480. Age-related changes in the content of sirtuin 1 in fibroblasts of human dermis
  1481. Effects of Berberine on Hepatic Sirtuin 1-uncoupling Protein 2 Pathway in Non-alcoholic Fatty Liver Disease Rats Induced by High-fat Diet
  1482. Sirtuin 6 builds a wall against inflammation, trumping diabetes
  1483. Effect of metformin on Sirtuin-1 disorders associated with diabetes in male rats
  1484. Immunohistochemistry and clinical value of sirtuin 2 in non-metastasized non-small cell lung cancer
  1485. Evaluation of Sirtuin-3 probe quality and co-expressed genes using literature cohesion
  1486. Sirtuin 1 evaluation with a novel immunoassay approach based on TiO2–Au label and hyperbranched polymer hybrid
  1487. Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia
  1488. Dietary restriction and Sirtuin 1 in metabolic health: connections and divergences
  1489. Sirtuin activator and inhibitor affect early Dictyostelium development upon starvation
  1490. … of D-Glucose, Extends the Lifespan of Caenorhabditis elegans via Sirtuin and Insulin Signaling D-Allose Extends Nematode Lifespan via Sirtuin and Insulin Signaling
  1491. 5-Methylmellein is a novel inhibitor of fungal sirtuin and modulates fungal secondary metabolite production
  1492. Corrigendum to “Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from …
  1493. Biochemical insight into pseudouridine synthase 7 (PUS7) as a novel interactor of sirtuin, SIRT1
  1494. The key role of microRNA-34a in the reduction of sirtuin-1 in COPD
  1495. MicroRNA‑506 regulates apoptosis in retinoblastoma cells by targeting sirtuin 1
  1496. Small-Molecules Targeting Sirtuin 1: A Patent Review (2012-2015)
  1497. The small RNA microRNA-212 regulates sirtuin 2 expression in a cellular model of oxygen-glucose deprivation
  1498. #VALUE!
  1499. Apelin and Sirtuin 1 dysregulation induce endocrine and metabolic disorders in chronic disease
  1500. Sirtuin 1 activation and cardioprotective role: thy eternal summer shall not fade
  1501. Silymarin protects against high fat diet-evoked metabolic injury by induction of glucagon-like peptide 1 and sirtuin 1
  1502. Natural mineral-rich water ingestion by ovariectomized fructose-fed Sprague-Dawley rats: effects on sirtuin 1 and glucocorticoid signaling pathways
  1503. Sir2D, a Sirtuin family protein, regulates adenylate cyclase A expression through interaction with the MybB transcription factor early in Dictyostelium …
  1504. Cyclic Peptide-Based Sirtuin Substrates
  1505. Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast …
  1506. Peripheral levels of BDNF and sirtuin 1 in migraine
  1507. Sirtuin 5 promotes ischemia/reperfusion-induced blood-brain barrier damage after stroke
  1508. #VALUE!
  1509. Effects of 10 weeks of high intensity interval training and green tea supplementation on serum levels of Sirtuin-1 and peroxisome proliferator-activated receptor …
  1510. Detection of Sirtuin-1 protein expression in peripheral blood leukocytes in dogs
  1511. Immunohistochemical examination of osteopontin and sirtuin-1 expression in cattle tuberculosis
  1512. Changes in the Expression and the Role of Sirtuin 3 in Cancer Cells and in Cardiovascular Health and Disease
  1513. Intracellular localization of sirtuin and cell length analysis of Lactobacillus paracasei suggest possible role of sirtuin in cell division and cell shape regulation
  1514. Identification of sirtuin and its target as the ribosomal protein S4 in Lactobacillus paracasei
  1515. Significant association of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) rs3846662 and sirtuin 1 (SIRT1) rs7895833 and apolipoprotein E (APOE) …
  1516. Resveratrol inhibits phosphorylation within the signal transduction and activator of transcription 3 signaling pathway by activating sirtuin 1 in SW1353 …
  1517. Sirtuin 1: A New Potential Therapeutic Target for Rhinosinusitis? Who “Nose”?
  1518. The Potential Impact of Sirtuin 1 Protein on Premature Ovarian Insufficiency
  1519. Electroacupuncture reduces obesity by improving metabolism and up-regulating expression of hypothalamic Sirtuin 1 and proopiomelanocortin in obese rats
  1520. Low Rap1-interacting factor 1 and sirtuin 6 expression predict poor outcome in radiotherapy-treated Hodgkin lymphoma patients
  1521. Age-Related Changes in the Content of Sirtuin 1 in Human Dermal Fibroblasts
  1522. Sirtuin 1 gene rs2273773 C> T single nucleotide polymorphism and protein oxidation markers in asthmatic patients
  1523. The effects of 10 weeks of high-intensity interval training and green tea supplementation on serum levels of sirtuin 1 and catalase in overweight women
  1524. The pathophysiological importance and therapeutic potential of NAD’biosynthesis and mitochondrial sirtuin SIRT3 in age-associated diseases.
  1525. Assessment of Sirtuin 3 and Sirtuin 4 Level in Patients with Diabetes Mellitus and Periodontitis: A Clinical Study.
  1526. Toxicarioside H induces drug-resistant mitophagy via promoting expression of sirtuin-3 in lung cancer cells
  1527. Discovery of (5-phenylfuran-2-yl) methanamine derivatives as new human Sirtuin 2 inhibitors
  1528. Fission yeast sirtuin Hst4 functions in preserving genomic integrity by regulating replisome component Mcl1
  1529. Possible role of Sirtuin in neuronal mitochondrial energy cascade for memory cognition
  1530. MicroRNA‑448 modulates the progression of neuropathic pain by targeting sirtuin 1
  1531. Deficiency of Sirtuin 3 Accentuates Angiotensin II‐Induced Arterial/Myocardial Stiffness and Hypertension
  1532. Adiponectin receptor 1-mediated micro RNA-323-3p regulates functions of the MIN6 cell line via the AMP-activated protein kinase/sirtuin-1 pathway
  1533. SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae))
  1534. 1819-P: Growth Hormone Receptor (GHR) in AgRP Neurons Modulates Energy Balance and Metabolic Adaptation to Fasting via Sirtuin 1 (SIRT1)
  1535. The Nicotinamide Adenine Dinucleotide (NAD)-dependent deacetylase Sirtuin-1 regulates chondrocyte energy metabolism through the modulation of …
  1536. MicroRNA‑29c restores cisplatin sensitivity in liver cancer through direct inhibition of sirtuin 1 expression
  1537. Impact of NAD-dependent deacetylase Sirtuin-1 in the osteophyte formation and the degradation of articular cartilage in osteoarthritis (OA)
  1538. Therapeutic Potential of Sirtuin Inhibitors in Cancer
  1539. Protective effects of aspirin and vitamin C against corn syrup consumption-induced cardiac damage through sirtuin-1 and HIF-1 [alpha] pathway
  1540. Mitophagy induced by endoplasmic reticulum stress in heart is modulated by the sirtuin 1
  1541. P2624 The contribution of Sirtuin-1 to the obesity-related endothelial dysfunction
  1542. Nicotinamide phosphoribosyltransferase contributes to cocaine addiction through sirtuin 1
  1543. L-arginine, an active component of salmon milt nucleoprotein, promotes thermotolerance via Sirtuin in Caenorhabditis elegans
  1544. Resveratrol increases sirtuin 1 expression in peripheral blood mononuclear cells of premature infants and inhibits the oxidative stress induced by hyperoxia in vivo
  1545. Regulation of human sirtuin deacylase activity by cellular oxidants
  1546. NAD+ as a Pharmacological Tool to Boost Sirtuin Activity
  1547. The protective effect of Egb 761 against 3-nitropropionic acid-induced hearing loss: the role of sirtuin 1
  1548. Effects of Sirtuin 2 on Hepatitis B Virus Replication
  1549. Sirtuin Modulators and Brain Aging
  1550. Effects of LPA2R, LPA3R, or EP4R agonists on luteal or endometrial function in vivo or in vitro and sirtuin or EP1R, EP2R, EP3R or EP4R agonists on endometrial …
  1551. Sirtuin-2 is Regulated by Serum Response Factor and p49/STRAP genes
  1552. Correction: Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice
  1553. microRNA-802 is involved in palmitate-induced damage to pancreatic β cells through repression of sirtuin 6
  1554. 2182 Sirtuin 5 regulates arterial thrombosis by modulating endothelial plasminogen activator inhibitor-1
  1555. PC200 A Deacetylase Enzyme, Sirtuin 3, Plays a Major Role in Macrophage Inflammation and Wound Healing
  1556. Molecular, Cellular, and Physiological Characterization of Sirtuin 7 (SIRT7)
  1557. The nuclear sirtuin SIRT6 promotes epithelial-mesenchymal transition in human melanoma cells
  1558. Effects of myeloid sirtuin 1 deficiency on hypothalamic neurogranin in mice fed a high-fat diet
  1559. Molecular responses to whole-body dehydration in a sequenced vertebrate, Xenopus laevis: Regulation of antioxidants and metabolism by the Sirtuin protein …
  1560. … , interleukin-1B downregulates chondrocyte energy metabolism through the modulation of adenosine monophosphate-activated protein kinase and sirtuin 1 in OA
  1561. Azologization of a hetero-stilbene based c-RAF kinase inhibitor: Towards the design of photoswitchable sirtuin inhibitors
  1562. Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
  1563. Triiodothyronine improves age-induced glucose intolerance and increases the expression of sirtuin-1 and glucose transporter-4 in skeletal muscle of aged rats.
  1564. Sirtuin 1 regulation of mitophagy and function in hindlimb muscles of aging mice
  1565. … , poly (ADP-ribose) polymerase-1 (PARP1) expression in intra-testicular blood vessels, and stage-dependent expression of PARP1 and Sirtuin 1 in the rat …
  1566. Relationship of fibroblast growth factor 21, sirtuin 1, visfatin, and regulators in children with short stature
  1567. Recombinant Preparation, Biochemical Analysis, and Structure Determination of Sirtuin Family Histone/Protein Deacylases
  1568. Regulation of Sirtuin-dependent skin cell Senescence by dermatology-associated compounds
  1569. Mitochondrial function and sirtuin expression in hippocampus of young and old high-and low-capacity runner rats
  1570. Effects of Pilates Training and Turmeric Supplementation on Sirtuin 1 Level and Body Composition in Postmenopausal Females with Sedentary Overweight: A …
  1571. Association of sirtuin 1 gene single nucleotide polymorphisms with type 2 diabetes mellitus in essential hypertension patients
  1572. Sirtuin‐1 deacetylation of p53 plays a role in shear stress‐induced autophagy in endothelial cells
  1573. Chromone-3-aldehyde derivatives–sirtuin 2 inhibitors for correction of muscular dysfunction
  1574. RNA-binding protein HuR inhibits the expression of sirtuin-1 in patients with COPD
  1575. Sirtuin 1 as a potential therapeutic target in pulmonary artery hypertension
  1576. Deregulation of selective autophagy & sirtuin 3 expression in lung aging and pulmonary fibrosis
  1577. Beyond longevity: novel roles of Sirtuin-3 in thrombosis
  1578. Association of variable number tandem repeat polymorphism of Intron 5 of the Sirtuin-3 Gene with the risk of breast cancer
  1579. Global Profiling of Sirtuin Deacylase Substrates Using a Chemical Proteomic Strategy and Validation by Fluorescent Labeling
  1580. Sirtuin 3 ablation exacerbates cerebral injury after experimental cardiac surgery via inflammasome activation
  1581. P5381 Lack of sirtuin 5 aggravates myocardial ischemia reperfusion injury
  1582. … Prevention of Cigarette Smoke-Induced Inflammatory Lung Lesions Independent of Carotenoid Cleavage Enzymes and Mechanistic Understanding of Sirtuin 1 …
  1583. Sirtuin 3 Expression and Acetylation of Three Downstream Targets in Painted Turtle Liver and Brain During Anoxia
  1584. Sirtuin Inhibitor as a Novel Cell Cycle Checkpoint and Regulator of the TP53-MDM2 Pathway in Uveal Melanoma
  1585. Influence of treatment of periodontal disease on sirtuin 1 and mannose-binding lectin in individuals with coronary artery disease
  1586. AB0044 PHARMACOLOGICAL MANIPULATION OF SIRTUIN 1 ACTIVITY IN EXPERIMENTALLY INDUCED ARTHRITIS
  1587. Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D mediated by sirtuin-3
  1588. GW27-e1067 Resveratrol Protects against TNF-α-Induced Injury in Human Umbilical Endothelial Cells through Promoting Sirtuin-1-Induced Repression of NF-KB and …
  1589. SIRTUIN 3 REGULATES THE ENDOTHELIAL-TO-MESENCHYMAL TRANSITION BY IMPROVING AUTOPHAGIC DEGRADATION PYRUVATE KINASE M2
  1590. Determining the Conservation and Metabolic Role of Sirtuin Lipoamidase Activity
  1591. A6645 Sirtuin 3-mediated glycolysis enhancing during Angiotension II-induced endothelial-to-mesenchymal transition
  1592. Sirtuin-regulated lipoylation is an evolutionarily conserved mediator of metabolic health and disease
  1593. The Sirtuin SIRT6 Represses Expression of Cachexia‐Associated Cytokine Myostatin by Blocking its NF‐kB‐Dependent Gene Transcription
  1594. A6555 Sirtuin 3-induced macrophage autophagy in regulating NLRP3 inflammasome activation
  1595. Exploring the role of sirtuin 2 in lipid homeostasis
  1596. #VALUE!
  1597. Decreased serum sirtuin-1 in chronic obstructive pulmonary disease
  1598. Investigating Sirtuin-3 in Host Defense Against HCMV Infection
  1599. Effect of 1.2-epoxy-3 [3-3 [3.4-dimetoxyi-phenil]-4h-1-benzopiran-4-on] Propane (epi) on Sirtuin-1 and Nuclear Factor-κB Expression of DMBA induced …
  1600. Sirtuin 2 Promotes Collagen II Synthesis Through Deacetylating p65-NF-κB in Human Intervertebral Disc Cartilage Endplate Cells
  1601. Sex-Specific Behavioural Traits of the Sirtuin-3 Knockout Mouse Model
  1602. Roles of Sirtuin family in non-small cell lung cancer
  1603. Role of Sirtuin 3 in the differentiation of 3T3-L1 preadipocytes
  1604. Epigenetic regulation of sirtuin 1‐induced skeletal muscle mass: exercise and heart disease
  1605. Neuron survival modulated by 24-hydroxycholesterol: the role of sirtuin pathway in Alzheimer’s Disease.
  1606. Characterizing a novel bacterial sirtuin protein in an intact protein system
  1607. The role of sirtuin in the growth and encystation of Acanthamoeba
  1608. Myeloid Sirtuin 6 Deficiency Accelerates Experimental and Human Rheumatoid Arthritis by Enhancing Macrophage Activation and Infiltration into Synovium
  1609. Unraveling the Role of Sirtuin 2 in Metabolic Homeostasis
  1610. Validation of Sirtuin 3 as a Neuroprotective and Neurorestorative Target in the Mutant Human A53T α-synuclein Rat Model of Parkinson’s Disease
  1611. The Role of Sirtuin-2 in Ischaemic Stroke-Induced Neuronal Cell Death
  1612. Insights into the role of sirtuin 2 in obesity and insulin resistance
  1613. Role of Sirtuin 6 in Mouse Pancreatic Beta Cell Development and Homeostasis
  1614. The Role of Sirtuin 6 in Maintaining Vascular Integrity
  1615. The Role of Sirtuin 3 in Ovarian Cancer Metastasis
  1616. Investigating the Role of Sirtuin 1 in the Pulmonary Vascular Response to Chronic Hypoxia-Induced Pulmonary Hypertension
  1617. Sirtuin 6 (SIRT6) overexpression regulates antioxidant status and redox signaling in human chondrocytes
  1618. Identification of bichalcones as natural product sirtuin inhibitors by virtual screening and in vitro testing
  1619. Ablation of Sirtuin 1 Deacetylase Activity Induces Pulmonary Emphysema by Inducing Cellular Senescence and Disrupting Circadian Clock in Mice (P01-022-19)
  1620. Diagnosis and Management of Immunological Diseases requires Sirtuin 1 as a Diagnostic protein marker
  1621. Serum sirtuin-1 is reduced in COPD
  1622. Sirtuin-1 and MMP-2 levels in patients with advanced coronary artery disease: A combined index for incidence of myocardial infarction
  1623. Transcriptional Dysregulation of Sirtuin 1 is Relevant to Diabetes and Global Chronic Disease
  1624. Inhibition of Profibrotic Signaling in Primary Fibroblasts from Patients with Idiopathic Pulmonary Fibrosis (IPF) by Sirtuin-1/-2-Inhibitor Sirtinol
  1625. Structural and Mechanistic Insights in Sirtuin Catalysis and Pharmacological Modulation
  1626. The sirtuin family of proteins: the role in the aging processes and regulation of cell metabolism.
  1627. THU0099 Myeloid sirtuin 6 deficiency accelerates experimental and human arthritis by increasing macrophage infiltration into synovium
  1628. Ligand Binding and Catalysis in Selected Sirtuin Isozymes
  1629. The effects of Sirtuin 6 inhibition on autophagy-related pathways in melanoma
  1630. OP0291 ACTIVATION OF THE DEACETYLASE SIRTUIN-1 COUNTERACTS THE ACTIVATED AND PROANGIOGENIC PROFILE OF ENDOTHELIAL CELLS …
  1631. Inter-individual responses to high intensity interval training: interactions with the sirtuin system
  1632. Expression and significance of Sirtuin 1 in human colorectal cancer
  1633. Investigating Human Mitochondrial Sirtuin 3 and its Anti-Viral Functions
  1634. #VALUE!
  1635. Effects of sirtuin 1 on arterial stiffening in a model of diet-induced obesity
  1636. Examining the Effect of Oxidative Stress on Tetrahymena Thermophila Sirtuin, THD17
  1637. Corrigendum to ‘Sirtuin 5 as a novel target to blunt blood–brain barrier damage induced by cerebral ischemia/reperfusion injury'[Int. J. Cardiol. 260 (2018) 148–155]
  1638. A prospective compound screening contest identified broader inhibitors for Sirtuin
  1639. A synthetic non-histone substrate provides insight into substrate targeting by the Gcn5 HAT and sirtuin HDACs
  1640. Sirtuin 1 (SIRT1) and activated caspase 3 expression on rat spinal cord in acute phase after Sciatic nerve injury
  1641. Investigating the Impact of Oxidative Stress on Tetrahymena Thermophila Sirtuin, THD 18
  1642. SAT0029 Impact of glucocorticoids on sirtuin 1 expression and proinflammatory cytokine production in rats with adjuvant-induced arthritis
  1643. Potential Involvement and Significance of Histone Deacetylase Sirtuin-6 in Melanoma
  1644. Effects of liraglutide on the biological behavior of human endothelial colony forming cell induced by high glucose via regulating sirtuin expression
  1645. Metformin regulates sirtuin expression in airway epithelial cells
  1646. Computational approach towards sirtuin inhibitors: application of molecular docking methods
  1647. Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma
  1648. Small solute carrier and sirtuin genes are potential prognostic biomarkers for renal cell carcinoma
  1649. EFFECTS OF PERSPECTIVE SIRTUIN-1 ACTIVATOR ON ENERGY HOMEOSTASIS CONSTITUENTS IN RATS WITH E XPERIMENTAL T YPE 2 DIABETES …
  1650. THE ROLE OF SIRTUIN-2 IN ISCHAEMIC STROKE-INDUCED NEURONAL CELL DEATH
  1651. Tissue Specific Reductions in Sirtuin-6 Expression Affect Calcium Burden and Pro-osteogenic Signaling in the Aortic Valve
  1652. The Nuclear Sirtuin, Sirt6 Mitigates Muscle Atrophy Associated With Cancer
  1653. DEFINING THE FUNCTIONS OF HUMAN SIRTUIN 2 IN CELLULAR HOUSEKEEPING AND DURING VIRAL INFECTION
  1654. Cardiovascular effects of the sirtuin and urocortin systems in humans
  1655. In silico-driven strategies for the identification of novel sirtuin modulators
  1656. Morphological characterization of a dietary challenged Sirtuin 1 heterozygous mice
  1657. PROLONGATION OF HUMAN LIFESPAN BY IMMATURE PEAR EXTRACT MEDIATED SIRTUIN-RELATED GENE EXPRESSION
  1658. Frontispiece: Mechanism‐Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure–Activity Relationship, Biostructural, and Kinetic Insight
  1659. The NAD+-Dependent Histone Deacetylase Sirtuin-2 is Upregulated during Myogenesis and Promotes the Differentiation of C2C12 Myoblasts
  1660. P5329Gene expression of sirtuin-1 and receptor for advanced glycation end products in healthy and slightly overweight subjects after caloric restriction and resveratrol …
  1661. Regulation of acetyl-CoA metabolism in plants: Role of acetyl-CoA synthetase and sirtuin proteins
  1662. 1765-P: Adipose Sirtuin 6 Drives Macrophage Polarization Toward M2 through IL-4 Production and Maintains Systemic Insulin Sensitivity in Mice and Human
  1663. The Investigation of Sirtuin Activities on Short-Chained Mono-Acylated Histone H3 Tetramers and Nucleosomes
  1664. Front Cover: Development of Substrate‐Derived Sirtuin Inhibitors with Potential Anticancer Activity (ChemMedChem 20/2017)
  1665. Sirtuin 3‐and Diet‐Mediated Regulation of Mitochondrial Function During Aging
  1666. The thrifty phenotype hypothesis: is sirtuin 6 the solution to the enigma?
  1667. Sirtuin-1 Signaling Regulates Organismal Growth by Altering Feeding Behavior and Stem Cell Differentiation in Planarians.
  1668. Evidence for the interplay between post‐translational modifications in regulating mycobacterial sirtuin activity
  1669. Sirtuin-3 modulates Bak-and Bax-dependent apoptosis
  1670. Vascular Smooth Muscle Sirtuin-1 Regulates Tgf-b1 Signaling Pathway in Angiotensin II-induced Aortic Aneurysm and Dissection
  1671. BIOINFORMATIC ANALYSES OF METALLOME AND STRUCTURAL ANALYSIS OF SIRTUIN FROM Glaciozyma antarctica PI12
  1672. Sirtuin 1 Prevents Age-associated Aortic Valve Calcification in vivo
  1673. #VALUE!
  1674. In vitro study of in silico designed sirtuin 1 and bromodomain 4 inhibitors on human neuroblastoma SH-SY5Y and acute myeloid leukemia U937 cells
  1675. Sirtuin-cAMP crosstalk in metabolic diseases: nucleus versus mitochondria
  1676. #VALUE!
  1677. #VALUE!
  1678. A12686 The sirtuin 6 attenuates myocardial injury and dysfunction by regulating ADAM17/ACE2 pathway in hypertensive rats
  1679. Expression Grade Sirtuin-1 (SIRT-1) in Tumor Tissue in Women with Breast Cancer: A New Biomarker Prognosis?
  1680. Modulation of Sirtuin NAD+‐dependent Deacylase Activity by Cysteine Oxidation
  1681. Effects of Resveratrol Postconditioning on Cerebral Ischemia in mice: Role of the Sirtuin-1 (SIRT1) Pathway
  1682. Amiodarone induces autophagy/mitophagy by activating sirtuin-3 in acute myelocytic leukemia
  1683. Effects of vitamin D supplementation on sirtuin-1, Angiogenesis fac-tors and Matrix metalloproteinases enzmes in Obese subjects with Vitamin D Insufficiency …
  1684. The role of sirtuin 2 in oligodendroglia on dopaminergic neuron differentiation and regeneration
  1685. Retraction notice to-Sirtuin-4 modulates sensitivity to induction of the mitochondrial permeability transition pore
  1686. Re: Sirtuin 3 Suppresses the Formation of Renal Calcium Oxalate Crystals through Promoting M2 Polarization of Macrophages
  1687. MicroRNA-141 Directly Targets and Inhibits Sirtuins 1 Gene Expression and Its Elevation in Obese Subjects is Responsible for Reduced Levels of Sirtuin 1 and the …
  1688. Exploring the Functions of Cytoplasmic Sirtuin 2 during Herpesvirus Infection
  1689. Hypomethylated CG islands of sirtuin promoters in gilthead sea bream (Sparus aurata)
  1690. Roles of Sirtuin 1 Activity and Tomato Carotenoids in the Development of Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma
  1691. Functional Role of Sirtuin 3 in the Regulation of Pancreatic Beta-Cell Function in Type 2 Diabetes
  1692. SHEAR STRESS INCREASES SIRTUIN 3 EXPRESSION AND PROMOTES MITOCHONDRIAL FUNCTIONS IN ENDOTHELIAL CELLS
  1693. Regulation of histone H2A. Z expression is mediated by sirtuin 1 in prostate cancer
  1694. Absence of Functional Sirtuin 3 Alters Fatty Acid and Glucose Metabolism Following 4-OH-PCB11 Exposure
  1695. Melatonin fails to protect cardiac mitochondria in sirtuin 1 heterozygous mice placed on a high-fat diet
  1696. The Role of Sirtuin 1 in the Regulation of Autophagy and Respiratory Syncytial Virus-induced Immune Responses
  1697. Sirtuin 1 Downregulation Exacerbates Fibrosis and Inflammation in Obese Mice Liver
  1698. Post-translational lysine-acetylation of Ran and its regulation by Sirtuin deacetylases
  1699. The Sirtuin Inhibitor Tenovin-6 as a Novel Regulator of the TP53-MDM2 Signaling Pathway in Uveal Melanoma
  1700. NAD~+ de novo synthesis from tryptophan metabolism sustains Sirtuin 1 dependent Immune Tolerance
  1701. Vascular smooth muscle Sirtuin-1 protects against aortic dissection during angiotensin II-induced hypertension
  1702. Sirtuin 4 controls leucine metabolism and insulin secretion by reversing effects of reactive metabolites
  1703. Unripe pear fruit extract induces the transcriptional activity of sirtuin-related genes to extend the chronological lifespan of Saccharomyces cerevisiae
  1704. Expression of Concern: Sirtuin-3 modulates Bak-and Bax-dependent apoptosis. Manish Verma, Nataly Shulga, John G. Pastorino. J Cell Sci
  1705. microRNA-138-5p Participates in Psoriasis Progress Through Regulating the Growth of Keratinocytes and Inflammatory Responses by Targeting Sirtuin 1
  1706. Hydrogen sulfide protects mitochondrial function during myocardial hypertrophy via sirtuin 3
  1707. Sirtuin 7 Is Associated With Pulmonary Fibrosis And Attenuates Collagen Expression In Lung Fibroblasts
  1708. The effect of aerobic training with Citrus aurantium L. on Sirtuin 1 and peroxisome proliferator-activated receptor gamma coactivator 1-alpha gene expression …
  1709. MicroRNA-9 represses sirtuin 1 (SIRT1) in human keratinocytes
  1710. Sirtuin 3 is a Novel Regulator of Mitochondrial Ceramide Metabolism in Stroke
  1711. Sirtuin-1 Inhibition by Peroxynitrite Contributes to Nicotine-induced Arterial Stiffness in Mice
  1712. Effects of muscle-specific UCP1 overexpression on spermatogenesis and mitochondrial sirtuin expression in the testis
  1713. Elevation of Cardiac NAD+ Levels Improves Mitochondrial Function in Mice Lacking Sirtuin 3
  1714. Translational Research in Acute Lung Injury and Pulmonary Fibrosis: Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung …
  1715. Retraction notice to:” Role of Mammalian sirtuin 1 (SIRT1) in lipids metabolism and cell proliferation of goose primary hepatocytes” MCE Volume 382, Issue 1, 25 …
  1716. Long-term therapy with elamipretide normalizes sirtuin-3 protein levels in isolated mitochondria of left ventricular myocardium of dogs with chronic heart failure
  1717. Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site,” selectivity pocket” and NAD+-binding site
  1718. Increased Deacetylation of Proteins in Sensory Neurons by Sirtuin 1 Protein Overexpression Reverses T2D Peripheral Neuropathy
  1719. Muscle‐Specific Over‐Expression of the NAD+‐Dependent Nuclear Sirtuin SIRT6, Suppresses Cancer‐Associated Cachexia
  1720. Comparison of resveratrol supplementation and calorie restricted diet on nutritional status, metabolic and oxidative parameters, serum sirtuin-1 and fibroblast growth …
  1721. The relationship between renalase together with catecholamines and anti-aging factors-sirtuin 1 and αKlotho in hemodialysis patients.
  1722. Myeloid sirtuin 6 deletion delays wound healing in mice by modulating inflammation and macrophage phenotype
  1723. Effect of hypoxic preconditioning on sirtuin 1 and sirtuin 3 expressions in alpha7 nicotinic receptor deficient mice brain at chronic cerebral hypoperfusion
  1724. Sirtuin 1 (SIRT1) Content and Angiotensin II Receptor Type I (AT1) Expression in Human Umbilical Vein Endothelial Cells (HUVECs) in Response to Resveratrol …
  1725. NeuroprotectinD1 (NPD1) mediates Sirtuin signaling in cell survival under-uncompensated oxidative stress in Retinal Pigment Epithelial (RPE) cells
  1726. PM2. 5 Activates Sirtuin‐SREBP1‐PIR Axis to Induce Pulmonary Fibroblast Inflammation: A Molecular Mechanism Model of Environmental Factor Induced Lung …
  1727. Resveratrol Can Improve Chronic Hypoxia Induced Pulmonary Hypertension Only In Absence Of Sirtuin 1 Catalytic Activity
  1728. Mechanisms of Sirtuin-2 (SIRT2) enhancement of mitochondrial function and axon regeneration in control and diabetic adult sensory neurons
  1729. Sex-Specific Cardioprotective Effects of Annexin A1 Peptide Mimetic Involve the Sirtuin 3 Signaling Pathway
  1730. Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria
  1731. Dichloroacetate Fails to Improve Exaggerated Chronic-Hypoxia Induced Pulmonary Hypertension in Sirtuin 1 Mutant Mice
  1732. Corrigendum to” Sirtuin 3 Rescues Neurons Through the Stabilisation of Mitochondrial Biogenetics in the Virally-Expressing Mutant α-synuclein Rat Model of …
  1733. Secretome released from adipose mesenchymal stem cells protects SH-SY5Y cells from oxidative stress and increases sirtuin 3 expression
  1734. 2026-P: Myeloid Sirtuin 6 Is a Molecular Switch of White Adipose Tissue Browning
  1735. Functional Link Between Heat Shock Protein HSP90alpha and Sirtuin 1 (SIRT1) in the Pathogenesis of Diffuse Large B Cell Lymphoma
  1736. … Kinase With Dichloroacetate in Pulmonary Arterial Hypertension: A Variable Clinical Response Driven by Genetic Polymorphisms in Sirtuin-3 and Uncoupling Protein …
  1737. Abstract C11: Linoleic acid elevates sirtuin 6 expression and modulates glycolysis and epithelial-mesenchymal transition of pancreatic cancer with loss of Krüpple like …
  1738. Expression of Concern: Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D mediated by sirtuin-3. Nataly Shulga …
  1739. Expression of Concern: Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria. Nataly Shulga, Robin Wilson-Smith, John …
  1740. NAD-dependent deacetylase Sirtuin-1 down-regulates expressions of osteogenic transcription facter RUNX2 and matrix metaprotinase (MMP)-13 in osteoarthritic …
  1741. Resveratrol induces apoptosis of bovine adipocytes through activiate of sirtuin type 1/adenosine monophosphate activated protein kinase signaling pathway.
  1742. Abstract P180: Deficiency of Sirtuin 3 Sensitizes Angiotensin II-Induced Cardiac Pericyte-Fibroblast Transition and Diastolic Dysfunction via Iron Overloading
  1743. The NAD-dependent deacetylase sirtuin-1 regulates the expression of osteogenic transcriptional activator Runt-related transcription factor 2 (Runx2) and production of …
  1744. … : BREATHLESS IN SAN FRANCISCO: Resveratrol Can Improve Chronic Hypoxia Induced Pulmonary Hypertension Only In Absence Of Sirtuin 1 Catalytic Activity
  1745. The nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin-1 regulates chondrocyte energy metabolism through the modulation of adenosine …
  1746. … and NAD+-Dependent (Ie Sirtuins) Histone Deacetylases (HDACS) on Innate Immune Responses: Lessons from the Usage of HDAC Inhibitors and Sirtuin …
  1747. Genetic Deletion of Sirtuin 3 (SIRT3) in the Mitochondria of the Proximal Tubules Aggravates Angiotensin II-Induced Hypertension by Impairing the Pressure …
  1748. PSXIII-3 Maternal eicosapentaenoic acid feeding decreases placental and fetal lipid deposition and improves antioxidant capacity through a Sirtuin-1 independent
  1749. Analysis of caspase-1 regulated transcriptome in various tissues lead to identification of novel IL-1β, IL-18 and sirtuin-1 intendent pathways
  1750. … PROTECTS AGAINST TNF-α-INDUCED INJURY IN HUMAN UMBILICAL ENDOTHELIAL CELLS THROUGH PROMOTING SIRTUIN-1-INDUCED REPRESSION OF …
  1751. The insulin/IGF-1, the sirtuin and the mTOR pathway. How alterations of these pathways could affect age-related diseases and lifespan.
  1752. Nicotinamide riboside affects toll‐like receptor 4‐NF‐κB pathway via sirtuin‐dependent and–independent ways in AML12 hepatocytes
  1753. The effects of conjugated linoleic acid supplementation on the serum levels of Interleukin-6 and Sirtuin-1 in COPD patients
  1754. 0433: Sirtuin 3: does cardiomyocyte care?
  1755. P002: MicroRNA-378b represses the expression of α-1-type 1 collagen through interference with sirtuin 6
  1756. The silver lining of cerebrosterol in Alzheimer’s disease: the involvement of sirtuin 1 in neuroprotection
  1757. Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1
  1758. DJ-1 and its anti-oxidative stress response regulates the expression of sirtuin-1 in COPD epithelial cells
  1759. The effects of conjugated linoleic acid supplementation on the serum levels of Interleukin-6 and Sirtuin-1 in COPD patients
  1760. Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target
  1761. Mechanism of activation for the sirtuin 6 protein deacylase
  1762. Host sirtuin 2 as an immunotherapeutic target against tuberculosis
  1763. Emerging role of sirtuin 2 in Parkinson’s disease
  1764. Sirtuin modulators: where are we now? A review of patents from 2015 to 2019
  1765. Sirtuin 6: A potential therapeutic target for cardiovascular diseases
  1766. The versatility of sirtuin-1 in endocrinology and immunology
  1767. Sirtuin 1 and endothelial glycocalyx
  1768. The sirtuin 6: An overture in skin cancer
  1769. A Molecular Perspective on Sirtuin Activity
  1770. Sirtuin-1 and its relevance in vascular calcification
  1771. Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators
  1772. Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery
  1773. Antioxidant modulation of sirtuin 3 during acute inflammatory pain: The ROS control
  1774. Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging—A Systematic Review
  1775. Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes
  1776. Sirtuin 2 regulates protein lactoylLys modifications
  1777. Effects of galloflavin and ellagic acid on sirtuin 6 and its anti-tumorigenic activities
  1778. Post-translational modification crosstalk and hotspots in sirtuin interactors implicated in cardiovascular diseases
  1779. Sirtuin 1 regulates mitochondrial function and immune homeostasis in respiratory syncytial virus infected dendritic cells
  1780. Sirtuin 1: a dilemma in transplantation
  1781. Antioxidant modulation of mTOR and sirtuin pathways in age-related neurodegenerative diseases
  1782. The role of Sirtuin-1 in the vasculature: focus on aortic aneurysm
  1783. Sirtuin 6: linking longevity with genome and epigenome stability
  1784. Sirtuin activation targets IDH-mutant tumors
  1785. Molecular mechanisms of doxorubicin-induced cardiotoxicity: Novel roles of sirtuin 1-mediated signaling pathways
  1786. RTN4B‐mediated suppression of Sirtuin 2 activity ameliorates β‐amyloid pathology and cognitive impairment in Alzheimer’s disease mouse model
  1787. Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model
  1788. Sirtuin 5 promotes arterial thrombosis by blunting the fibrinolytic system
  1789. Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway
  1790. Five days periodic fasting elevates levels of longevity related christensenella and sirtuin expression in humans
  1791. Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice
  1792. Targeting sirtuin activity with nicotinamide riboside reduces neuroinflammation in a GWI mouse model
  1793. Hypertension and mitochondrial oxidative stress revisited: sirtuin 3, the improved “antioxidant”
  1794. Sirtuin 1 inhibiting thiocyanates (S1th)—a new class of isotype selective inhibitors of NAD+ dependent lysine deacetylases
  1795. Legionella pneumophila infection rewires the Acanthamoeba castellanii transcriptome, highlighting a class of sirtuin genes
  1796. Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control
  1797. Sirtuin 3 is essential for hypertension‐induced cardiac fibrosis via mediating pericyte transition
  1798. Interplay between NADH oxidation by complex I, glutathione redox state and sirtuin-3, and its role in the development of insulin resistance
  1799. Impact of neural stem cell‐derived extracellular vesicles on mitochondrial dysfunction, sirtuin 1 level, and synaptic deficits in Alzheimer’s disease
  1800. The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders
  1801. Targeting Sirtuin 1 signaling pathway by ginsenosides
  1802. Structural basis for activation of human Sirtuin 6 by fluvastatin
  1803. Cardioprotective effects of sirtuin-1 and its downstream effectors: potential role in mediating the heart failure benefits of SGLT2 (sodium-glucose cotransporter 2) …
  1804. Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins
  1805. Dual role of sirtuin 1 in inflammatory bowel disease
  1806. Sustained activation of AMPK enhances differentiation of human iPSC-derived cardiomyocytes via sirtuin activation
  1807. The deacetylase sirtuin 6 protects against kidney fibrosis by epigenetically blocking β-catenin target gene expression
  1808. Lactate increases renal cell carcinoma aggressiveness through sirtuin 1-dependent epithelial mesenchymal transition axis regulation
  1809. Endothelial sirtuin 3 dictates glucose transport to cardiomyocyte and sensitizes pressure overload‐induced heart failure
  1810. Impact of sirtuin enzymes on the altered metabolic phenotype of malignantly transformed cells
  1811. Fucoxanthin mitigates subarachnoid hemorrhage-induced oxidative damage via sirtuin 1-dependent pathway
  1812. Concerted action of AMPK and Sirtuin-1 induces mitochondrial fragmentation upon inhibition of Ca2+ transfer to mitochondria
  1813. Astaxanthin inhibits alcohol-induced inflammation and oxidative stress in macrophages in a sirtuin 1-dependent manner
  1814. Nimbolide abrogates cerulein-induced chronic pancreatitis by modulating β-catenin/Smad in a sirtuin-dependent way
  1815. Wolbachia and Sirtuin-4 interaction is associated with alterations in host glucose metabolism and bacterial titer
  1816. Suppression of sirtuin 1 alleviates airway inflammation through mTOR‑mediated autophagy
  1817. Effects of triclosan on the RedoximiRs/Sirtuin/Nrf2/ARE signaling pathway in mosquitofish (Gambusia affinis)
  1818. Calycosin ameliorates doxorubicin‐induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1–NOD‐like receptor protein 3 pathway
  1819. Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation
  1820. Development of a mitochondrial sirtuin 4 FRET assay based on its activity for removing 3-hydroxy-3-methylglutaryl (HMG) modification
  1821. Silencing Sirtuin 6 induces cell cycle arrest and apoptosis in non-small cell lung cancer cell lines
  1822. Sirtuin 3 Downregulation in Mycobacterium tuberculosis-Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death
  1823. Sirtuin acetylation and deacetylation: a complex paradigm in neurodegenerative disease
  1824. Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice
  1825. Interplay of adenosine monophosphate‐activated protein kinase/sirtuin‐1 activation and sodium influx inhibition mediates the renal benefits of sodium‐glucose co …
  1826. Downregulation of circular RNA circPVT1 restricts cell growth of hepatocellular carcinoma through downregulation of Sirtuin 7 via microRNA‐3666
  1827. Berberine increases glucose uptake and intracellular ROS levels by promoting Sirtuin 3 ubiquitination
  1828. Histone acetyltransferase p300 inhibitor improves coronary flow reserve in SIRT3 (sirtuin 3) knockout mice
  1829. Parasitic sirtuin 2 as an opportunity in drug discovery
  1830. Sirtuin 6 is a regulator of dendrite morphogenesis in rat hippocampal neurons
  1831. Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner
  1832. Sirtuin 2 inhibition attenuates sevoflurane-induced learning and memory deficits in developing rats via modulating microglial activation
  1833. The effects of curcumin supplementation on oxidative stress, Sirtuin-1 and peroxisome proliferator activated receptor γ coactivator 1α gene expression in polycystic …
  1834. Sirtuin 1 deficiency decreases bone mass and increases bone marrow adiposity in a mouse model of chronic energy deficiency
  1835. Impact of nutrition on short-term exercise-induced sirtuin regulation: Vegans differ from omnivores and lacto-ovo vegetarians
  1836. DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing—a possible predictive biomarker for malignant transformation
  1837. Sirtuin 5 regulates the proliferation, invasion and migration of prostate cancer cells through acetyl‐CoA acetyltransferase 1
  1838. Statin suppresses sirtuin 6 through miR-495, increasing FoxO1-dependent hepatic gluconeogenesis
  1839. Cytoplasmic sirtuin 6 translocation mediated by p62 polyubiquitination plays a critical role in cadmium-induced kidney toxicity
  1840. Sirtuin inhibits M. tuberculosis-induced apoptosis in macrophage through glycogen synthase kinase-3β
  1841. Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double …
  1842. Sirtuin 6 attenuates epithelial–mesenchymal transition by suppressing the TGF-β1/Smad3 pathway and c-Jun in asthma models
  1843. Ethanol exposure attenuates immune response in sepsis via sirtuin 2 expression
  1844. The cAMP pathway promotes sirtuin-1 expression in human granulosa-lutein cells
  1845. Sirtuins and the circadian clock interplay in cardioprotection: Focus on sirtuin 1
  1846. Sirtuin 3 is required for the protective effect of Resveratrol on Manganese‐induced disruption of mitochondrial biogenesis in primary cultured neurons
  1847. Grape Cane Extracts as Multifunctional Rejuvenating Cosmetic Ingredient: Evaluation of Sirtuin Activity, Tyrosinase Inhibition and Bioavailability Potential
  1848. Cardiomyocyte Sirt (Sirtuin) 7 ameliorates stress-induced cardiac hypertrophy by interacting with and deacetylating GATA4
  1849. A new vision of mitochondrial unfolded protein response to the sirtuin family
  1850. Inhibition of alcohol-induced inflammation and oxidative stress by astaxanthin is mediated by its opposite actions in the regulation of sirtuin 1 and histone deacetylase …
  1851. Sirtuin-1 regulates organismal growth by altering feeding behavior and intestinal morphology in planarians
  1852. Sirtuin 5 depletion impairs mitochondrial function in human proximal tubular epithelial cells
  1853. Sirtuin 1 activation alleviates primary biliary cholangitis via the blocking of the NF-κB signaling pathway
  1854. Sirtuin 3 inhibits airway epithelial mitochondrial oxidative stress in cigarette smoke-induced COPD
  1855. An alternatively spliced sirtuin 2 isoform 5 inhibits hepatitis B virus replication from cccDNA by repressing epigenetic modifications made by histone lysine …
  1856. Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3
  1857. Genetic Analysis of Sirtuin Deacetylases in Hyphal Growth of Candida albicans
  1858. Resistance training increases muscle NAD+ and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight …
  1859. Sirtuin 3 alleviates diabetic cardiomyopathy by regulating TIGAR and cardiomyocyte metabolism
  1860. Oxidized nicotinamide adenine dinucleotide-dependent mitochondrial deacetylase sirtuin-3 as a potential therapeutic target of Parkinson’s disease
  1861. Sirtuin 3 activation by honokiol decreases unilateral ureteral obstruction-induced renal inflammation and fibrosis via regulation of mitochondrial dynamics and the …
  1862. Development of Fluorogenic Probes for Rapid High‐Contrast Imaging of Transient Nuclear Localization of Sirtuin 3
  1863. Melatonin prevents deterioration of erectile function in streptozotocin‐induced diabetic rats via sirtuin‐1 expression
  1864. A Set of Highly Sensitive Sirtuin Fluorescence Probes for Screening Small-Molecular Sirtuin Defatty-Acylase Inhibitors
  1865. Sirtuin 3 governs autophagy‐dependent glycolysis during Angiotensin II‐induced endothelial‐to‐mesenchymal transition
  1866. Sirtuin-1 expression and activity is diminished in aged liver grafts
  1867. Inonotsuoxide B regulates M1 to M2 macrophage polarization through sirtuin-1/endoplasmic reticulum stress axis
  1868. SIRT3 (sirtuin-3) prevents Ang II (angiotensin II)–induced macrophage metabolic switch improving perivascular adipose tissue function
  1869. Promising drug discovery strategies for sirtuin modulators: what lessons have we learnt?
  1870. Progranulin modulates cartilage-specific gene expression via sirtuin 1–mediated deacetylation of the transcription factors SOX9 and P65
  1871. Aging-related overactivity of the angiotensin/AT1 axis decreases sirtuin 3 levels in the substantia nigra, which induces vulnerability to oxidative stress and …
  1872. Baicalin protects against 17α-ethinylestradiol-induced cholestasis via the sirtuin 1/hepatic nuclear receptor-1α/farnesoid X receptor pathway
  1873. Deficiency of sirtuin 1 impedes endometrial decidualization in recurrent implantation failure patients
  1874. Sirtuin 2 (SIRT2): Confusing Roles in the Pathophysiology of Neurological Disorders
  1875. Sirtuin 3 regulates mitochondrial protein acetylation and metabolism in tubular epithelial cells during renal fibrosis
  1876. Sirtuin 7 promotes non‑small cell lung cancer progression by facilitating G1/S phase and epithelial‑mesenchymal transition and activating AKT and ERK1/2 …
  1877. Proteomics analysis reveals the effect of Aeromonas hydrophila sirtuin CobB on biological functions
  1878. Loss of Sirtuin 6 in osteoblast lineage cells activates osteoclasts, resulting in osteopenia
  1879. Is nuclear sirtuin SIRT6 a master regulator of immune function?
  1880. Aqueous extract of Whitmania Pigra Whitman alleviates thrombus burden via sirtuin 1/NF-κB pathway
  1881. Sirtuin-3 mediates sex differences in kidney ischemia-reperfusion injury
  1882. Epigenetic Regulation Associated With Sirtuin 1 in Complications of Diabetes Mellitus
  1883. Sirtuin 2 Dysregulates Autophagy in High-Fat-Exposed Immune-Tolerant Macrophages
  1884. Icariin modulates the sirtuin/NF‑κB pathway and exerts anti‑aging effects in human lung fibroblasts
  1885. Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression
  1886. Genetic ablation of Fas-activated serine/threonine kinase ameliorates obesity-related hepatic glucose and lipid metabolic disorders via sirtuin-1 signaling
  1887. Sirtuin 1-dependent regulation of high mobility box 1 in hypoxia–reoxygenated brain microvascular endothelial cells: roles in neuronal amyloidogenesis
  1888. … lupus nephritis benefits from treatment with honokiol by immunoregulation and differentially regulating NF‐κB/NLRP3 inflammasome and sirtuin 1/autophagy axis
  1889. Upregulated tumor sirtuin 2 expression correlates with reduced TNM stage and better overall survival in surgical breast cancer patients
  1890. Sirtuin 6 and renal injury: another link in the β-catenin chain?
  1891. The Pan-Sirtuin Inhibitor MC2494 Regulates Mitochondrial Function in a Leukemia Cell Line
  1892. Sirtuin 1 is not required for contraction-stimulated glucose uptake in mouse skeletal muscle
  1893. Genetic Manipulation of Sirtuin 3 Causes Alterations of Key Metabolic Regulators in Melanoma
  1894. Deacetylation-activated construction of single quantum dot-based nanosensor for sirtuin 1 assay
  1895. Low expression of sirtuin 1 in the dairy cows with mild fatty liver alters hepatic lipid metabolism
  1896. The antiviral sirtuin 3 bridges protein acetylation to mitochondrial integrity and metabolism during human cytomegalovirus infection
  1897. The role of sirtuin 1 on the induction of trained immunity
  1898. Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress‐induced premature senescence
  1899. Demalonylation of DDX3 by Sirtuin 5 promotes antiviral innate immune responses
  1900. Ginsenoside Rb1 reduces H2O2‑induced HUVEC dysfunction by stimulating the sirtuin‑1/AMP‑activated protein kinase pathway
  1901. Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1
  1902. Role of N-terminus in function and dynamics of sirtuin 7: an in silico study
  1903. The Role of Sirtuin-1 in Immune Response and Systemic Lupus Erythematosus
  1904. Sirtuin 6 and metabolic genes interplay in Warburg effect in cancers
  1905. Sirtuin-1 inhibits endothelin-2 expression in human granulosa-lutein cells via hypoxia inducible factor 1 alpha and epigenetic modifications
  1906. Pancreatic Sirtuin 3 deficiency promotes hepatic steatosis by enhancing 5-hydroxytryptamine synthesis in diet-induced obese mice
  1907. Sirtuin 3 improves fatty acid metabolism in response to high nonesterified fatty acids in calf hepatocytes by modulating gene expression
  1908. Sirtuin-1 Inhibits Endothelin-2 Expression in Human Granulosa-Lutein Cells via HIF1A and Epigenetic Modifications
  1909. Granulosa-Lutein Cell Sirtuin Gene Expression Profiles Differ between Normal Donors and Infertile Women
  1910. Discovery of new human Sirtuin 5 inhibitors by mimicking glutaryl-lysine substrates
  1911. A fungal sirtuin modulates development and virulence in the insect pathogen, Beauveria bassiana
  1912. Sirtuin Control of Mitochondrial Dysfunction, Oxidative Stress, and Inflammation in Chagas Disease Models
  1913. Sirtuin 3‐mediated deacetylation of acyl‐CoA synthetase family member 3 by protocatechuic acid attenuates non‐alcoholic fatty liver disease
  1914. The sirtuin inhibitor cambinol reduces intracellular glucosylceramide with ceramide accumulation by inhibiting glucosylceramide synthase
  1915. Sirtuin 6 promotes eosinophil differentiation by activating GATA‐1 transcription factor
  1916. Berberine Ameliorates Subarachnoid Hemorrhage Injury via Induction of Sirtuin 1 and Inhibiting HMGB1/Nf-κB Pathway
  1917. Local DNA methylation helps to regulate muscle sirtuin 1 gene expression across seasons and advancing age in gilthead sea bream (Sparus aurata)
  1918. Hypothalamic NAD+-Sirtuin Axis: Function and Regulation
  1919. Investigation of sirtuin 1 polymorphisms in relation to the risk of colorectal cancer by molecular subtype
  1920. Inhibition of aerobic glycolysis alleviates sepsis‑induced acute kidney injury by promoting lactate/Sirtuin 3/AMPK‑regulated autophagy
  1921. Modulation of the bacterial CobB sirtuin deacylase activity by N-terminal acetylation
  1922. The investigation of the role of sirtuin-1 on embryo implantation in oxidative stress–induced mice
  1923. Sirtuin (Sirt) 3 overexpression prevents retinopathy in streptozotocin-induced diabetic rats
  1924. Propofol reduces renal ischemia/reperfusion-induced acute lung injury by stimulating sirtuin 1 and inhibiting pyroptosis
  1925. Biochemical characterization of mono ADP ribosyl transferase activity of human sirtuin SIRT7 and its regulation
  1926. Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease
  1927. Long noncoding RNA‐GAS5 attenuates progression of glioma by eliminating microRNA‐10b and Sirtuin 1 in U251 and A172 cells
  1928. Daytime Dependence of the Activity of the Rat Brain Pyruvate Dehydrogenase Corresponds to the Mitochondrial Sirtuin 3 Level and Acetylation of Brain Proteins, All …
  1929. The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury
  1930. BZD9L1 sirtuin inhibitor: Identification of key molecular targets and their biological functions in HCT116 colorectal cancer cells
  1931. A novel resveratrol analog upregulates sirtuin 1 and inhibits inflammatory cell infiltration in acute pancreatitis
  1932. Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease
  1933. Effects of perinatal factors on sirtuin 3, 8-hydroxy-2′-deoxyguanosine, brain-derived neurotrophic factor and serotonin in cord blood and early breast milk: an …
  1934. Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling
  1935. … -pituitary ovarian axis (HPO) in female mammals: role of mTOR (mammalian target of rapamycin), AMPK (AMP-activated protein kinase) and SIRT1 (Sirtuin 1)
  1936. E3 ubiquitin ligase HRD1 promotes lung tumorigenesis by promoting sirtuin 2 ubiquitination and degradation
  1937. Impact of glucocorticoids on systemic sirtuin 1 expression and activity in rats with adjuvant-induced arthritis
  1938. … of alpha-lipoic acid supplementation and electrical isotonic contraction on anthropometric measurements and the serum levels of VEGF, NO, sirtuin-1, and PGC1-α in …
  1939. Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation
  1940. Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes
  1941. Aβ-induced damage memory in hCMEC/D3 cells mediated by Sirtuin-1
  1942. … ‐Targeted Sirtuin‐Rearranging Ligand (SirReal) for the Development of Proteolysis‐Targeting Chimeras (PROTACs) against the Lysine Deacetylase Sirtuin 2 …
  1943. Sirtuin 1 as the mechanism of action of agents used in the diabetes mellitus pharmacotherapy
  1944. Grape seed proanthocyanidins improves mitochondrial function and reduces oxidative stress through an increase in sirtuin 3 expression in EA. hy926 cells in high …
  1945. Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-κB Pathways
  1946. A Synthetic Epoxydocosapentaenoic Acid Analogue Ameliorates Cardiac Ischemia/Reperfusion Injury: The Involvement of the Sirtuin 3–NLRP3 Pathway
  1947. … of Cell Senescence in CD34+ CD38− Leukemia Stem Cells Derived from KG1α Acute Myeloid Leukemia Cells by Activating the Sirtuin 1 (SIRT1)/Tuberous …
  1948. Phylogenetic diversification of sirtuin genes with a description of a new family member
  1949. Natural Sirtuin Modulators in Drug Discovery: A Review (2010-2020)
  1950. DeepSIRT: A deep neural network for identification of sirtuin targets and their subcellular localizations
  1951. Understanding the Potential Role of Sirtuin 2 on Aging: Consequences of SIRT2. 3 Overexpression in Senescence
  1952. Terminating rice innate immunity induction requires a network of antagonistic and redox‐responsive E3 ubiquitin ligases targeting a fungal sirtuin
  1953. Influence of the treatment of periodontal disease in serum concentration of sirtuin 1 and mannose‐binding lectin
  1954. Glutaredoxin-2 and Sirtuin-3 deficiencies impair cardiac mitochondrial energetics but their effects are not additive
  1955. Prenatal androgen excess impairs beta-cell function by decreased sirtuin 3 expression
  1956. β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice
  1957. Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors
  1958. Pancreatic sirtuin 3 deficiency promotes hepatic steatosis by enhancing 5-Hydroxytryptamine synthesis in mice with diet-induced obesity
  1959. Angiotensin II-induced overexpression of sirtuin 1 contributes to enhanced expression of Giα proteins and hyperproliferation of vascular smooth muscle cells
  1960. Aging exaggerates acute‐on‐chronic alcohol‐induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1‐C/EBPα‐miRNA‐223 axis
  1961. A scaffold replacement approach towards new sirtuin 2 inhibitors
  1962. Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma
  1963. Sirtuin-dependent recovery from aerial heat shock: The effects of food ration, thermal history, and sirtuin inhibition on clearance rates and valve gape activity of the …
  1964. Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and osteoclastsogenesis via suppressing ERK and JNK signaling
  1965. Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span
  1966. Analysis of Sirtuin 1 and Sirtuin 3 at Enzyme and Protein Levels in Human Breast Milk during the Neonatal Period
  1967. Alternative Splicing Increases Sirtuin Gene Family Diversity and Modulates Their Subcellular Localization and Function
  1968. Experimental studies on the protective effects of the overexpression of lentivirus-mediated sirtuin 6 on radiation-induced lung injury.
  1969. Effects of androgens and estrogens on sirtuin 1 gene expression in human aortic endothelial cells
  1970. Blood Pressure-Lowering Effect of Wine Lees Phenolic Compounds Is Mediated by Endothelial-Derived Factors: Role of Sirtuin 1
  1971. Sirtuin 1 rs7069102 polymorphism is associated with diabetic nephropathy in patients with type 2 diabetes mellitus
  1972. The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy
  1973. The Sirtuin‐1 relied antioxidant and antiaging activity of 5, 5′‐diferulic acid glucoside esters derived from corn bran by enzymatic method
  1974. Kumiss supplementation reduces oxidative stress and activates sirtuin deacetylases by regulating antioxidant system
  1975. Nicotinamide riboside, an NAD+ precursor, attenuates inflammation and oxidative stress by activating sirtuin 1 in alcohol-stimulated macrophages
  1976. Sirtuin 1 and 2 inhibitors enhance the inhibitory effect of sorafenib in hepatocellular carcinoma cells
  1977. Sirtuin 3 inhibits nuclear factor-κB signaling activated by a fatty acid challenge in bovine mammary epithelial cells
  1978. Role of sirtuin-1 (SIRT1) in hypoxic injury in pancreatic β-cells
  1979. Activation of sirtuin 2 inhibitors employing photoswitchable geometry and aqueous solubility
  1980. Sirtuin GdSir2.4 participates in the regulation of rRNA transcription in the Giardia duodenalis parasite
  1981. Sirtuin-dependent reversible lysine acetylation controls the activity of acetyl-Coenzyme A synthetase in Campylobacter jejuni
  1982. FSH, oxytocin and IGF-I regulate the expression of sirtuin 1 in porcine ovarian granulosa cells
  1983. Plasma levels of sirtuin-1 in patients with cerebrovascular stroke
  1984. Prospective, case-controlled study evaluating serum concentration of sirtuin-1 and mannose-binding lectin in patients with and without periodontal and coronary artery …
  1985. Oxidized GAPDH transfers S-glutathionylation to a nuclear protein Sirtuin-1 leading to apoptosis
  1986. Impairment of sirtuin 1-mediated DNA repair is involved in bisphenol A-induced aggravation of macrophage inflammation and atherosclerosis
  1987. … ameliorated high-fat diet (HFD)-induced non-alcoholic fatty liver disease and upregulated the nicotinamide adenine dinucleotide+/Sirtuin-1 pathway in mice
  1988. Annexin A1 tripeptide mimetic increases sirtuin-3 and augments mitochondrial function to limit ischemic kidney injury
  1989. … II-Induced Cardiac Fibroblast Proliferation and Transverse Aortic Constriction-Induced Myocardial Fibrosis through Oxidative Stress Inhibition via Sirtuin 3
  1990. Sirtuin signaling in hematologic malignancies
  1991. Sirtuin 3 mRNA Expression is Downregulated in the Brain Tissues of Alzheimer’s Disease Patients: A Bioinformatic and Data Mining Approach
  1992. Molecular docking and mechanisms of fusaric acid induced mitochondrial sirtuin aberrations in glycolytically and oxidatively poised human hepatocellular carcinoma …
  1993. Mechanisms and neuroprotective activities of stigmasterol against oxidative stress-induced neuronal cell death via sirtuin family
  1994. A sex-specific role of endothelial Sirtuin 3 on blood pressure and diastolic dysfunction in female mice
  1995. MicroRNA-148b Inhibits the Malignant Biological Behavior of Melanoma by Reducing Sirtuin 7 Expression Levels
  1996. Sirtuin SirD is involved in α-amylase activity and citric acid production in Aspergillus luchuensis mut. kawachii during a solid-state fermentation process
  1997. Ginsenoside Rg1 performs anti-aging functions by suppressing mitochondrial pathway-mediated apoptosis and activating sirtuin 3 (SIRT3)/superoxide …
  1998. Silybin Restored CYP3A Expression through the Sirtuin 2/Nuclear Factor κ-B Pathway in Mouse Nonalcoholic Fatty Liver Disease
  1999. The lifespan extension ability of nicotinic acid depends on whether the intracellular NAD+ level is lower than the sirtuin-saturating concentrations
  2000. Validation of the Slow Off‐Kinetics of Sirtuin‐Rearranging Ligands (SirReals) by Means of Label‐Free Electrically Switchable Nanolever Technology
  2001. … , MnTE-2-PyP, treatment protects the prostate from radiation-induced fibrosis (RIF) by activating the NRF2 signaling pathway and enhancing SOD2 and sirtuin activity
  2002. Energy intake focused analysis of sexual dimorphism in biological aging and hypothesized sex-specificity in sirtuin dependency
  2003. Skeletal muscle‐specific over‐expression of the nuclear sirtuin SIRT6 blocks cancer‐associated cachexia by regulating multiple targets
  2004. Protective Effects of N1-Methylnicotinamide Against High-Fat Diet-and Age-Induced Hearing Loss via Moderate Overexpression of Sirtuin 1 Protein
  2005. Exploring the role of orexin B-sirtuin 1-HIF-1α in diabetes-mellitus induced vascular endothelial dysfunction and associated myocardial injury in rats
  2006. Smooth Muscle Sirtuin 1 Blocks Thoracic Aortic Aneurysm/Dissection Development in Mice
  2007. The possible role of sirtuin 5 in the pathogenesis of apical periodontitis
  2008. … phospholipids and eicosapentaenoic acid-enriched phospholipids inhibit tumor necrosis factor-alpha-induced lipolysis in 3T3-L1 adipocytes by activating sirtuin 1 …
  2009. Melatonin Inhibits Dengue Virus Infection via the Sirtuin 1-Mediated Interferon Pathway
  2010. Sirtuin 1 inhibitor EX527 suppresses morphine-induced behavioral sensitization
  2011. NAD+/sirtuin metabolism is enhanced in response to cold‐induced changes in lipid metabolism in mouse liver
  2012. Inter‐individual variation in postprandial glycaemic responses in women co‐ingesting green leafy vegetables with a carbohydrate meal: interactions with the sirtuin …
  2013. Sirtuin 6 ameliorates alcohol-induced liver injury by reducing endoplasmic reticulum stress in mice
  2014. Protective Effect of Sirtuin 3 on CLP-Induced Endothelial Dysfunction of Early Sepsis by Inhibiting NF-κB and NLRP3 Signaling Pathways
  2015. Sirtuin 6 attenuates angiotensin II-induced vascular adventitial aging in rat aortae by suppressing the NF-κB pathway
  2016. Heat shock protein 20 promotes sirtuin 1-dependent cell proliferation in induced pluripotent stem cells
  2017. Activation of AMP-Activated Protein Kinase-Sirtuin 1 Pathway Contributes to Salvianolic Acid A-Induced Browning of White Adipose Tissue in High-Fat Diet …
  2018. Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3β/β-catenin signalling …
  2019. Reduced leukocyte telomere lengths and sirtuin 1 gene expression in long‐term survivors of type 1 diabetes: A Dialong substudy
  2020. Sirtuin 3 therapy attenuates aging expression, oxidative stress parameters, and neointimal hyperplasia formation in vein grafts
  2021. Aconitine attenuates mitochondrial dysfunction of cardiomyocytes via promoting deacetylation of cyclophilin-D mediated by sirtuin-3
  2022. Muscle‐specific sirtuin 3 overexpression does not attenuate the pathological effects of high‐fat/high‐sucrose feeding but does enhance cardiac SERCA2a activity
  2023. Stereoisomer-specific ginsenoside 20 (S)-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mTOR-Sirtuin signaling
  2024. Ultrasound‑targeted microbubble destruction‑mediated overexpression of Sirtuin 3 inhibits the progression of ovarian cancer
  2025. Finding the gas pedal on a slow sirtuin
  2026. Molecular characterization and expression of sirtuin 2, sirtuin 3, and sirtuin 5 in the Wuchang bream (Megalobrama amblycephala) in response to acute temperature …
  2027. Sirtuin 6 supra‐physiological overexpression in hypothalamic pro‐opiomelanocortin neurons promotes obesity via the hypothalamus‐adipose axis
  2028. MicroRNA‐199a‐5p aggravates angiotensin II–induced vascular smooth muscle cell senescence by targeting Sirtuin‐1 in abdominal aortic aneurysm
  2029. Sirtuin 6 regulates the proliferation and survival of clear cell renal cell carcinoma cells via B‑cell lymphoma 2
  2030. Sirtuin 3 deficiency aggravates angiotensin II‐induced hypertensive cardiac injury by the impairment of lymphangiogenesis
  2031. Chronic Exercise Mitigates the Effects of Sirtuin Inhibition by Salermide on Endothelium-Dependent Vasodilation
  2032. Interaction of Sirtuin 1 (SIRT1) candidate longevity gene and particulate matter (PM2. 5) on all-cause mortality: a longitudinal cohort study in China
  2033. Changes in the Systemic Expression of Sirtuin-1 and Oxidative Stress after Intravitreal Anti-Vascular Endothelial Growth Factor in Patients with Retinal Vein Occlusion
  2034. In silico screening of small molecule modulators and their binding studies against human sirtuin-6 protein
  2035. Reverse expression pattern of sirtuin-1 and histone deacetylase-9 in coronary artery disease
  2036. A Theacrine-Based Supplement Increases Cellular NAD+ Levels and Affects Biomarkers Related to Sirtuin Activity in C2C12 Muscle Cells In Vitro
  2037. Saccharomyces boulardii modulates necrotizing enterocolitis in neonatal mice by regulating the sirtuin 1/NF‑κB pathway and the intestinal microbiota
  2038. Litopenaeus vannamei sirtuin 6 homolog (LvSIRT6) is involved in immune response by modulating hemocytes ROS production and apoptosis
  2039. Elucidation of the Mechanism Underlying the Anti-Inflammatory Properties of (S)-(+)-Carvone Identifies a Novel Class of Sirtuin-1 Activators in a Murine Macrophage …
  2040. Sirtuin 1 Expression in the Rat Ventromedial and Dorsomedial Hypothalamic Nuclei during Ageing
  2041. Sirtuin 1 alleviates neuroinflammation‐induced apoptosis after traumatic brain injury
  2042. Serum levels of visfatin, sirtuin-1, and interleukin-6 in stable and acute exacerbation of chronic obstructive pulmonary disease
  2043. Sirtuin 6 is a negative regulator of FcεRI signaling and anaphylactic responses
  2044. The Protective Effect of 1, 25 (OH) 2D3 on Myocardial Function is Mediated via Sirtuin 3-Regulated Fatty Acid Metabolism
  2045. Zinc, copper, sirtuin 1 concentration, and glucose metabolism parameters in the blood of women with polycystic ovary syndrome
  2046. Dethioacylation by sirtuins 1–3: considerations for drug design using mechanism-based sirtuin inhibition
  2047. Serum Levels of Sirtuin-1 in Patients with Lung Cancer and its Association with Karnofsky Performance Status
  2048. … prevents cadmium‐induced disorder of testicular lactic acid metabolism in rats by activating 5′ AMP‐activated protein kinase (AMPK)/sirtuin 1 (SIRT1) signaling …
  2049. Genomics of aging: The role of sirtuin and metabolic health
  2050. The effect of trans-palmitoleic acid on cell viability and sirtuin 1 gene expression in hepatocytes and the activity of peroxisome-proliferator-activated receptor …
  2051. Overexpression of sirtuin 2 and its association with prognosis in acute ischemic stroke patients
  2052. Surgery-induced downregulation of hippocampal sirtuin-1 contributes to cognitive dysfunction by inhibiting autophagy and activating apoptosis in aged mice
  2053. Sirtuin 3 Restores Synthesis and Secretion of Very Low-Density Lipoproteins in Cow Hepatocytes Challenged with Nonesterified Fatty Acids In Vitro
  2054. Sirtuin 1 promotes autophagy and proliferation of endometrial cancer cells by reducing acetylation level of LC3
  2055. Sirtuin 1 inhibits lipopolysaccharide-induced inflammation in chronic myelogenous leukemia k562 cells through interacting with the Toll-like receptor 4 …
  2056. 1, 4-Dihydropyridine (DHP) suppresses against oxidative stress in nucleus pulposus via activating sirtuin-1
  2057. Sirtuin-7 as a Novel Therapeutic Target in Vascular Smooth Muscle Cell Proliferation and Remodeling
  2058. Buyang Huanwu Decoction promotes neurogenesis via sirtuin 1/autophagy pathway in a cerebral ischemia model
  2059. Sirtuin 6 is Reduced in Alzheimer’s Disease (5101)
  2060. From anti-aging drugs to cancer therapy: is there a potential for sirtuin activators in gliomas?
  2061. Implication of the deacetylase sirtuin-1 on synovial angiogenesis and persistence of experimental arthritis
  2062. DPP-4 inhibitor induces FGF21 expression via sirtuin 1 signaling and improves myocardial energy metabolism
  2063. The long noncoding RNA MALAT1 suppresses miR‐211 to confer protection from ultraviolet‐mediated DNA damage in vitiligo epidermis by upregulating sirtuin 1*
  2064. Sirtuin 1: endocan and sestrin 2 in different biological samples in patients with asthma. Does severity make the difference?
  2065. Sirtuin 5, vascular endothelium and fibrinolysis: a deadly embrace?
  2066. Sirtuin 2 knockdown inhibits cell proliferation and RAS/ERK signaling, and promotes cell apoptosis and cell cycle arrest in multiple myeloma
  2067. The clinical value of serum sirtuin-1 in the diagnosis of rheumatoid arthritis: a pilot study
  2068. Evaluation of sirtuin 1 (SIRT1) levels in autosomal dominant polycystic kidney disease
  2069. Sirtuin 3 induces apoptosis and necroptosis by regulating mutant p53 expression in small‑cell lung cancer
  2070. Fasting and fasting mimetic supplementation address sirtuin expression, miRNA and microbiota composition
  2071. Clinical significance of sirtuin 1 level in sepsis: correlation with disease risk, severity, and mortality risk
  2072. Expression of sirtuin type 3 in locus ceruleus is associated with long-term intermittent hypoxia-induced neurocognitive impairment in mice
  2073. Apocynin protects retina cells from ultraviolet radiation damage via inducing sirtuin 1
  2074. Sirtuin 1 activated by SRT1460 protects against myocardial ischemia/reperfusion injury
  2075. Role of forkhead box protein O1 and insulin on cell proliferation mediated by sirtuin 1 in goose primary hepatocytes
  2076. MicroRNA-874-5p regulates autophagy and proliferation in pulmonary artery smooth muscle cells by targeting Sirtuin 3
  2077. Intermedin1-53 attenuates aging-associated vascular calcification in rats by upregulating sirtuin 1
  2078. Microglial Sirtuin 2 Shapes Long-Term Potentiation in Hippocampal Slices
  2079. Comparison of sirtuin 1 level and related blood factors in diabetic and healthy subjects.
  2080. Sirtuin 2 promotes cell stemness and MEK/ERK signaling pathway while reduces chemosensitivity in endometrial cancer
  2081. … upregulates miR-132/212 in Hirschsprung-associated enterocolitis, facilitating pyroptosis by activating NLRP3 inflammasome via targeting Sirtuin 1 (SIRT1)
  2082. The sirtuin 1 activator SRT1720 alleviated endotoxin-induced fulminant hepatitis in mice
  2083. Histone Deacetylase Sirtuin 2 Enhances Viability of Trophoblasts Through p65-Mediated MicroRNA-146a/ACKR2 Axis
  2084. Sirtuin 1 is involved in oleic acid-induced calf hepatocyte steatosis via alterations in lipid metabolism-related proteins
  2085. Sirtuin 6 protects human retinal pigment epithelium cells from LPS-induced inflammation and apoptosis partly by regulating autophagy
  2086. Sirtuin‐3 activation by honokiol restores mitochondrial dysfunction in the hippocampus of the hepatic encephalopathy rat model of ammonia neurotoxicity
  2087. Value of serum and follicular fluid sirtuin (SIRT) 1 and SIRT2 protein levels in predicting the outcome of assisted reproduction
  2088. Histone Deacetylase 1 and Sirtuin 1 Expression in Psoriatic Skin: A Comparison between Guttate and Plaque Psoriasis
  2089. Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes
  2090. Sirtuin 5 deficiency increases disease severity in rats with adjuvant-induced arthritis
  2091. Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction
  2092. Sirtuin-1 Sensitive Lysine-136 Acetylation Drives Phase Separation and Pathological Aggregation of TDP-43
  2093. Krüppel-Like Factor 6 Silencing Prevents Oxidative Stress and Neurological Dysfunction Following Intracerebral Hemorrhage via Sirtuin 5/Nrf2/HO-1 Axis
  2094. Effect of Aldosterone on Senescence and Proliferation Inhibition of Endothelial Progenitor Cells Induced by Sirtuin 1 (SIRT1) in Pulmonary Arterial …
  2095. Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis
  2096. Sirtuin 3 deficiency promotes acute kidney injury induced by sepsis via mitochondrial dysfunction and apoptosis
  2097. Single clove garlic extract increase sirtuin 6 mRNA expression in PBMC culture
  2098. Gene expression and prognosis of sirtuin family members in ovarian cancer
  2099. Sirtuin 2 expression levels may predict the progression of sepsis survivors to chronic critical illness
  2100. Combination of sirtuin 3 and hyperoxia diminishes tumorigenic properties of MDA-MB-231 cells
  2101. Discovery of Dihydro-1, 4-Benzoxazine Carboxamides as Potent and Highly Selective Inhibitors of Sirtuin-1
  2102. Sirtuin (SIRT)-1: At the crossroads of puberty and metabolism
  2103. The interaction of miR-181a-5p and sirtuin 1 regulated human bone marrow mesenchymal stem cells differentiation and apoptosis
  2104. Phosphodiesterase-1 inhibitor modulates Ca2+ regulation in sirtuin 1-deficient mouse cardiomyocytes
  2105. MicroRNA‑217 inhibits the proliferation and invasion, and promotes apoptosis of non‑small cell lung cancer cells by targeting sirtuin 1
  2106. SIRTUIN 1, a novel approach in the treatment of type 2 diabetes mellitus
  2107. Sirtuin 2 in Endometrial Cancer: A Potential Regulator for Cell Proliferation, Apoptosis and RAS/ERK Pathway
  2108. Sirtuin 7 Promotes Mesenchymal to Epithelial Transition by β-Catenin Redistribution and Stabilization
  2109. Interferon-γ inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b-dependent mechanism
  2110. Sirtuin regulation of NLRP3
  2111. Honokiol regulates endoplasmic reticulum stress by promoting the activation of the sirtuin 1-mediated protein kinase B pathway and ameliorates high glucose/high fat …
  2112. Pterostilbene and its nicotinate derivative ameliorated vascular endothelial senescence and elicited endothelium-dependent relaxations via activation of Sirtuin 1
  2113. The association between left ventricular mass index and serum sirtuin 3 level in patients with hypertension
  2114. Sirtuin Deacetylases: Linking Mycobacterial Infection and Host Metabolism
  2115. MicroRNA‑132 promotes oxidative stress‑induced pyroptosis by targeting sirtuin 1 in myocardial ischaemia‑reperfusion injury
  2116. Melatonin Lowers HIF-1α Content in Human Proximal Tubular Cells (HK-2) Due to Preventing Its Deacetylation by Sirtuin 1
  2117. MicroRNA‑138‑5p drives the progression of heart failure via inhibiting sirtuin 1 signaling
  2118. Suppression of microRNA-323-3p restrains vascular endothelial cell apoptosis via promoting sirtuin-1 expression in coronary heart disease
  2119. Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery
  2120. Taohuajing reduces oxidative stress and inflammation in diabetic cardiomyopathy through the sirtuin 1/nucleotide-binding oligomerization domain-like …
  2121. … (Nr4a1) and Liver Linase B1 (LKB1) Mitigates Type 2 Diabetes Mellitus by Activating Monophosphate-Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Axis …
  2122. MiR-140-3p inhibits the cell viability and promotes apoptosis of synovial fibroblasts in rheumatoid arthritis through targeting sirtuin 3
  2123. Role of Sirtuin-1 in Neonatal Hypoxic-Ischemic Encephalopathy and Its Underlying Mechanism
  2124. Sirtuin 3 deficiency accelerates Angiotensin II-induced skeletal muscle atrophy
  2125. 14-3-3 protein Bmh1 triggers short-range compaction of mitotic chromosomes by recruiting sirtuin deacetylase Hst2
  2126. Exploring the Sirtuin Functionality in Ageing Through Human Protein Interaction Networks
  2127. TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents
  2128. Combined effects on leukemia cell growth by targeting sphingosine kinase 1 and sirtuin 1 signaling
  2129. Absence of Sirtuin 1 impairs the testicular development in cattleyak by inactivating SF‐1
  2130. Effects of conjugated linoleic acid supplementation on serum levels of interleukin-6 and sirtuin 1 in COPD patients
  2131. Metabolism, Oxidative Stress and Cell Signaling: Interferon-γ inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b …
  2132. Overlapping tumor‐specific expression of p53, p16INK4a, and sirtuin 1 in Bowen’s disease: A case report
  2133. Astaxanthin inhibits alcohol-induced inflammation and oxidative stress by mediating the sirtuin 1 and histone deacetylase 4 axis in macrophages
  2134. MO084 THE INFLUENCE OF INTRAVENOUS CORTICOSTEROIDS ON PLASMA SIRTUIN-1 AND SCLEROSTIN LEVELS IN PATIENTS WITH PRIMARY …
  2135. Sirtuin-6 in Hepatic Fibrosis: Does Cell Type Matter?
  2136. Role of SIRTUIN 6 in vascular smooth muscle cells in atherosclerosis
  2137. Integrated Omics Analysis Reveals Sirtuin Signaling is Central to Hepatic Response to a High Fructose Diet
  2138. Role of Exercise and Natural Protective Substances on Sirtuin Activation
  2139. Resveratrol suppresses interleukin‐6 expression through activation of sirtuin 1 in hypertrophied H9c2 cardiomyoblasts
  2140. In silico Design of Novel Sirtuin 1 Enzyme Activators for Treatment of Age-related Diseases and Life Span.
  2141. … Induces Bone Formation by Activating Glucose Transporter 1 (Glut 1) in Osteoblasts, Inducing Signaling via NAD+-Dependent Deacetylase (Sirtuin 1) and Runt …
  2142. Increased Sirtuin expression, senescence regulating miRNAs, mtDNA, and bifidobacteria correlate with wellbeing and skin appearance after Sirtuin-activating drink
  2143. Association of sirtuin-1 and vascular endothelial growth factor expression with tumor progression and poor prognosis in liposarcoma
  2144. Reduced LINC00467 elevates microRNA-125a-3p to suppress cisplatin resistance in non-small cell lung cancer through inhibiting sirtuin 6 and inactivating the ERK1 …
  2145. Senescence associated long non-coding RNA 1 regulates cigarette smoke-induced senescence of type II alveolar epithelial cells through sirtuin-1 signaling
  2146. Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo
  2147. Protective effect of limonin against doxorubicin-induced cardiotoxicity via activating Nuclear factor-like 2 and Sirtuin 2 signaling pathways
  2148. Recent Trends on Telomerase Activators, Sirtuin Activators, and Senolytics as a Potential Anti-aging Agent
  2149. A Review of Sirtuin Inhibitors in Therapeutics, Pharmaceutics, and Plant Research
  2150. Hsa_circ_0006571 promotes spinal metastasis through sponging microRNA-138 to regulate sirtuin 1 expression in lung adenocarcinoma
  2151. Electroacupuncture Regulates Inguinal White Adipose Tissue Browning by Promoting Sirtuin-1-Dependent PPARγ Deacetylation and Mitochondrial …
  2152. Live-Cell Imaging of Sirtuin Activity Using a One-Step Fluorescence Probe
  2153. Resveratrol Pretreatment Ameliorates Concanavalin A-Induced Advanced Renal Glomerulosclerosis in Aged Mice through Upregulation of Sirtuin 1-Mediated Klotho …
  2154. miR-124-3p combined with miR-506-3p delay hepatic carcinogenesis via modulating sirtuin 1
  2155. Nonallosteric Sirtuin Enzyme Activation: Characterization of Hit Compounds
  2156. Developmental programming: intrauterine caloric restriction promotes upregulation of mitochondrial sirtuin with mild effects on oxidative parameters in the ovaries and …
  2157. At the Interface between Metabolism and Redox Regulation: Sirtuin 1 as Checkpoint for Neurogenesis and Longevity
  2158. … -23a reduces lipopolysaccharide-induced cellular apoptosis and inflammatory cytokine production through Rho-associated kinase 1/sirtuin-1/nuclear factor …
  2159. Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease
  2160. Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4α
  2161. … Fraction of Uncaria gambir Roxb. Improve Adipocytes Differentiation & Glucose Uptake of 3T3-L1 Cells Via Sirtuin-1, Peroxisome Proliferator-Activated …
  2162. Sirtuin 5 promotes arterial thrombosis through endothelial plasminogen activator inhibitor-1
  2163. Inhibition of miR-383 suppresses oxidative stress and improves endothelial function by increasing sirtuin 1
  2164. #VALUE!
  2165. Activation of Sirtuin 1 by Ellagic Acid Ameliorates Cisplatin-Induced Apoptosis, Oxidative Stress and Nephrotoxicity
  2166. Global query on bacterial sirtuin CobB interactants reveals crosstalk with PRPP synthase Prs
  2167. Maternally expressed 3 protects the intestinal barrier from cardiac arrest-induced ischemia/reperfusion injury via miR-34a-3p/sirtuin 1/nuclear factor kappa B …
  2168. Inhibition of the Peroxisome Proliferator-Activated Receptor gamma Coactivator 1-alpha (PGC-1α)/Sirtuin 3 (SIRT3) Pathway Aggravates Oxidative Stress …
  2169. Transcription box‑3 protects human umbilical vein endothelial cells in a high‑glucose environment through sirtuin 1/AKT signaling
  2170. Mitochondria dynamics in postmitotic cells drives neurogenesis through Sirtuin-dependent chromatin remodeling
  2171. The impact of moderate-intensity swimming exercise on learning and memory in aged rats: The role of Sirtuin-1
  2172. Buyang Huanwu Decoction Alleviates Cerebral Ischemia-Reperfusion Injury via Sirtuin 1/Autophagy Pathway
  2173. 9-Hydroxy-6, 7-dimethoxydalbergiquinol suppresses hydrogen peroxide-induced senescence in human dermal fibroblasts through induction of sirtuin-1 …
  2174. The Effects of NAD-Boosting Therapies on Sirtuin Activity and DNA Repair Capacity
  2175. Sirtuin 1 mediates hepatoprotective effects of resveratrol-like compounds in experimental liver injury
  2176. Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload
  2177. The effects of taurine supplementation on serum levels of adiponectin, irisin, fibroblast growth factor-21, sirtuin-1, metabolic parameters, oxidative/inflammatory …
  2178. The Effect of Sirtuin 2 (Sirt2) Overexpressing Bone Marrow Mesenchymal Stem Cells on the Growth of Human Epidermal Growth Factor Receptor 2 (Her-2) Breast …
  2179. Cilostazol improves hyperglycemia-induced impaired vasculo-angiogenesis through stimulating adiponectin/adiponectin receptor 1/Sirtuin 1 signaling pathway
  2180. The in vivo roles of Sirtuin 1 and 3 in age and obesity-related decline in female fertility
  2181. Analysis of Coding RNA and LncRNA Expression Profile of Stem Cells from the Apical Papilla After Depletion of Sirtuin 7
  2182. Sirtuin 4 contributes to heart failure development by increasing mitochondrial oxidative stress
  2183. Post-transcriptional Regulation of Lysosomal Function by the Lysine Deacylase Sirtuin 1
  2184. The Role of Sirtuin 1 in Palmitic-acid-induced Endoplasmic-reticulum Stress in Cardiac Myoblasts
  2185. Postprandial adropin responses in women co-ingesting green leafy vegetables with a carbohydrate meal: interactions with the sirtuin system
  2186. Ring finger protein 219 regulates inflammatory responses by stabilizing sirtuin 1
  2187. Effects of NAD+ Synthesis Levels on Sirtuin 1 Deacetylase Activity in Mammalian Cells
  2188. NAD+: a crucial regulator of sirtuin activity in aging
  2189. Role of Sirtuin-1 in the pathogenesis of hypertension in spontaneously hypertensive rats: molecular mechanisms
  2190. Evaluation of serum levels of Sirtuin-1 in lung cancer patients
  2191. Expression of Sirtuin 4 in Oral Squamous Cell Carcinoma and it’s Correlation with Clinicopathological Parameters
  2192. Withdrawal: Sirtuin 1-mediated deacetylation of XPA DNA repair protein enhances its interaction with ATR protein and promotes cAMP-induced DNA repair of UV …
  2193. Change in plasma sirtuin 1 level by injection into uterus of resveratrol in Korean cattle
  2194. Decreased expression and Activity of the desacetylase Sirtuin-1 contribute to the activated and proangiogenic profile of endothelial cells in rheumatoid arthritis and …
  2195. Regulation of Sirtuin NAD+-dependent Deacylase Activity by Cellular Oxidants
  2196. The Effects of a Theacrine-based Supplement on mRNAs Related to Various Metabolic Processes and Sirtuin Activity in vitro
  2197. Fat and Carbohydrate Distribution in Maternal Diet Programs Liver Sirtuin-1 Expression and Fatty acid Profile in Offspring
  2198. The Effect of Two-month Concurrent Training with and without Calorie Restriction on Sirtuin-1 Activity and Content in the Peripheral Blood Mononuclear Cells of …
  2199. Fat and Carbohydrate Distribution in Maternal Diet Programs Liver Sirtuin-1 Expression and Fatty Acid Profile in Mice Offspring
  2200. The Effect of Eight Weeks High Intensity Interval Training on Serum Levels of Telomerase Enzyme and Sirtuin 6 Protein in Aged Men
  2201. SERUM ANTI-AGING PROTEIN-SIRTUIN 1 CONCENTRATION CORRELATES WITH IMPAIRED KIDNEY FUNCTION
  2202. Corrigendum to” MicroRNA-128-3p Aggravates Doxorubicin-Induced Liver Injury by Promoting Oxidative Stress via Targeting Sirtuin-1″[Pharmacol. Res. 146 (2019) …
  2203. Association of hyperuricemia-induced renal damage with sirtuin 1 and endothelial nitric oxide synthase in rats
  2204. Cilostazol Induces eNOS and TM Expression via Activation with Sirtuin 1/Krüppel-like Factor 2 Pathway in Endothelial Cells
  2205. Exploring SIRT6 modulators and an indirect approach to regulate sirtuin activity
  2206. MiR-217 inhibition relieves oxidative stress-induced melanocyte damage by targeting sirtuin 1
  2207. Identification of small molecule sirtuin-1 inhibitors for treating acute myeloid leukemia based on molecular docking, quantitative structure-activity relationships and …
  2208. Role of vascular smooth muscle sirtuin-1 in the development of aortic aneurysm
  2209. Developmental Regulation of Sirtuin Genes in Broiler Chicks
  2210. Abstract MP55: Endothelial Sirtuin-1 Deficiency Promotes the Rupture of Intracranial Aneurysm
  2211. The role of Sirtuin in respiratory disease
  2212. Virtual screening and molecular modeling studies applied to discover novel sirtuin modulators and cholinesterase inhibitors:[kumulative Dissertation]
  2213. Sirtuin Correlation with p-value
  2214. Effects of 8 weeks of moderate continuous and intensive interval training on the expression of Sirtuin-1 and long-chain Acyl-CoA dehydrogenase gene in the heart …
  2215. Pharmacological Analysis and Molecular Docking of Laurus nobilis (Bay Leaf) for Lung Cancer with Reference to Sirtuin Drug Targets
  2216. Brown Adipose Tissue Promotes Exercise Capacity Through Sirtuin-3
  2217. Transcriptional Regulation of Fatty Acid Transport by Sirtuin 2
  2218. Front Cover: Validation of the Slow Off‐Kinetics of Sirtuin‐Rearranging Ligands (SirReals) by Means of Label‐Free Electrically Switchable Nanolever Technology …
  2219. Characterizing the Evolution and Function of a Sirtuin Deacetylase in the Pathogenic Yeast Candida parapsilosis
  2220. Nicotinamide Inhibits Glycolysis of HL-60 Cells by Modulating Sirtuin 1 (SIRT1)/Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α) …
  2221. Confirmation of Allosteric Switches in Human Sirtuin 1 Using a Sirtuin Activating Compound
  2222. BET Bromodomain Inhibition Results in the Conserved Upregulation of Sirtuin 1
  2223. Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and
  2224. … for A Synthetic Epoxydocosapentaenoic Acid Analogue Ameliorates Cardiac Ischemia/Reperfusion Injury: The Involvement of The Sirtuin 3-NLRP3 Pathway
  2225. The nuclear sirtuin SIRT6 protects mice from polymicrobial sepsis by suppressing the host immune response
  2226. The nuclear sirtuin SIRT6 plays a role in regulating cardiac branched‐chain amino acid catabolism
  2227. P021: Myeloid cell-specific sirtuin 6 deficiency delays wound healing in mice by modulating inflammation and macrophage phenotypes
  2228. … -four-component synthesis of 5-(4-hydroxy-2-oxo-1, 2-dihydropyridin-3-yl)-substituted 5H-chromeno [2, 3-b] pyridines and estimation of its affinity to sirtuin 2
  2229. Quinacrine ameliorated Cisplatin‐induced renal toxicity via modulation of Sirtuin‐1 and its downstream inflammatory and apoptosis pathways
  2230. Evaluation of phthalates exposition in sirtuin transcription in HepG2 cells and its toxicity in human hematopoietic stem cells
  2231. Molecular Cloning and Characterization of Sirtuin 1 and Its Potential Regulation of Lipid Metabolism and Antioxidant Response in Largemouth Bass …
  2232. Nicotinamide mononucleotide treatment increases NAD+ levels in an iPSC Model of Parkinson’s Disease but does not impact sirtuin activity
  2233. … Differences in Angiotensin II‐induced Hypertensive and Natriuretic Responses in Mice with Proximal Tubule‐Specific Deletion of Mitochondrial Protein Sirtuin 3 in The …
  2234. Activation of Sirtuin 1 (SIRT1) Signaling by Resveratrol Increases Human Beta‐Defensins‐2 and‐3 (HBD2, HBD3) Production in Response to Lipopolysaccharide …
  2235. 4528 Sirtuin 3 activation as a potential renoprotective therapy in a mouse model of Alport syndrome
  2236. PE-060: An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone …
  2237. Resveratrol Attenuates Incidence of Aortic Aneurysm by Decreasing Reversible Oxidation of Sirtuin-1 and Inhibiting Excessive Tgf-b1 in a Mouse Model of Marfan’s …
  2238. 1553: THE EFFECT OF SIRTUIN 1 ON MITOCHONDRIAL INJURY IN A RAT MODEL OF CARDIAC ARREST
  2239. Cytochrome P450‐Derived Epoxy Lipids of N‐3 PUFAs Protect the Heart From Ischemia‐Reperfusion Injury by Regulating Mitochondrial Sirtuin 3

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