“5′ AMP-activated protein kinase or AMPK or 5′ adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular energy homeostasis, largely to activate glucose and fatty acid uptake and oxidation when cellular energy is low. It belongs to a highly conserved eukaryoticprotein family and its orthologues are SNF1 and SnRK1 in yeast and plants, respectively. It consists of three proteins (subunits) that together make a functional enzyme, conserved from yeast to humans. It is expressed in a number of tissues, including the liver, brain, and skeletal muscle. In response to binding AMP and ADP, the net effect of AMPK activation is stimulation of hepatic fatty acid oxidation, ketogenesis, stimulation of skeletal muscle fatty acid oxidation and glucose uptake, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipogenesis, activation of adipocyte lipolysis, and modulation of insulin secretion by pancreatic beta-cells.[1]”
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
- AMPK: a nutrient and energy sensor that maintains energy5 homeostasis
- AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
- The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
- LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1
- AMPK and PPARδ Agonists Are Exercise Mimetics
- The LKB1–AMPK pathway: metabolism and growth control in tumour suppression
- TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
- The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR
- Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK– and COX-2–dependent mechanisms
- AMPK in Health and Disease
- PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
- AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation
- Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
- AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice
- AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome
- The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis
- Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia
- SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function
- Structure of mammalian AMPK and its regulation by ADP
- Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle
- Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks
- AMPK β Subunit Targets Metabolic Stress Sensing to Glycogen
- Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1
- AMPK: a key regulator of energy balance in the single cell and the whole organism
- Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
- Metabolism of inflammation limited by AMPK and pseudo-starvation
- Selective activation of AMPK-PGC-1α or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation
- AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
- Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt
- An AMPK-FOXO Pathway Mediates Longevity Induced by a Novel Method of Dietary Restriction in C. elegans
- AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase
- Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1
- Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner
- Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
- Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR
- Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
- Akt Activates the Mammalian Target of Rapamycin by Regulating Cellular ATP Level and AMPK Activity*
- Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
- AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARα and PGC-1
- The Regulation of AMPK β1, TSC2, and PTEN Expression by p53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways
- AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo
- The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
- AMPK, insulin resistance, and the metabolic syndrome
- AMPK: A Key Sensor of Fuel and Energy Status in Skeletal Muscle
- AMPK: a metabolic gauge regulating whole-body energy homeostasis
- AMPK, the metabolic syndrome and cancer
- AMP-Activated Protein Kinase (AMPK) Is Activated in Muscle of Subjects With Type 2 Diabetes During Exercise
- AMPK and cell proliferation – AMPK as a therapeutic target for atherosclerosis and cancer
- Ca2+ and AMPK Both Mediate Stimulation of Glucose Transport by Muscle Contractions
- AMPK and SIRT1: a long-standing partnership?
- Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
- AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
- Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
- The Association of AMPK with ULK1 Regulates Autophagy
- AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation
- AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets
- Physiological role of AMP-acivated proein kinase (AMPK): insights from knockout mouse models
- SNF1/AMPK pathways in yeast
- Effect of Exercise Intensity on Skeletal Muscle AMPK Signaling in Humans
- Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation
- 5′-AMP-Activated Protein Kinase (AMPK) Is Induced by Low-Oxygen and Glucose Deprivation Conditions Found in Solid-Tumor Microenvironments
- Important role fo the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
- Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
- A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway
- AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise
- The Glycogen-Binding Domain on the AMPK β Subunit Allows the Kinase to Act as a Glycogen Sensor
- Antidiabetic Activities of Triterpenoids Isolated from Bitter Melon Associated with Activation of the AMPK Pathway
- AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation
- Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy
- MicroRNA-451 Regulates LKB1/AMPK Signaling and Allows Adaptation to Metabolic Stress in Glioma Cells
- Effect of AMPK activation on muscle glucose metabolism in conscious rats
- TAK1 activates AMPK‐dependent cytoprotective autophagy in TRAIL‐treated epithelial cells
- Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle
- AMP-activated Protein Kinase (AMPK) Signaling in Endothelial Cells Is Essential for Angiogenesis in Response to Hypoxic Stress*
- New roles for the LKB1→AMPK pathway
- Acute Metformin Therapy Confers Cardioprotection Against Myocardial Infarction Via AMPK-eNOS–Mediated Signaling
- Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype
- Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway
- SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease
- Roles of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis
- Effects of α-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle
- Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway
- Effect of Acute Exercise on AMPK Signaling in Skeletal Muscle of Subjects With Type 2 Diabetes
- AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
- AMPK alterations in cardiac physiology and pathology: enemy or ally?
- Berberine suppresses proinflammatory responses through AMPK activation in macrophages
- AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues
- Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR
- AMPK: positive and negative regulation, and its role in whole-body energy homeostasis
- Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK
- Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer
- AMP-activated protein kinase (AMPK) β1β2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise
- SNF1/AMPK/SnRK1 kinases, global regulators at the heart of energy control?
- Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation
- Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK)
- AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer
- AMPK and the biochemistry of exercise: implications for human health and disease
- AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits
- Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism
- Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1
- Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L
- Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio
- β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)
- AMPK as a mediator of hormonal signalling
- Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease
- AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs
- AMPK as a metabolic tumor suppressor: control of metabolism and cell growth
- Mechanisms Linking Obesity, Chronic Kidney Disease, and Fatty Liver Disease: The Roles of Fetuin-A, Adiponectin, and AMPK
- Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB
- AMPK Mediates Autophagy during Myocardial Ischemia In Vivo
- Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK
- Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival
- AMPK inhibits fatty acid-induced increases in NF-κB transactivation in cultured human umbilical vein endothelial cells
- Structural basis of AMPK regulation by small molecule activators
- Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway
- AMPK in the brain: its roles in energy balance and neuroprotection
- CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK
- Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle
- Metformin Amplifies Chemotherapy-Induced AMPK Activation and Antitumoral Growth
- Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop
- AMPK inhibition in health and disease
- Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels
- α-Lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle
- Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK
- Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury
- AMPK—Sensing Energy while Talking to Other Signaling Pathways
- AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1
- Adiponectin Enhances IL-6 Production in Human Synovial Fibroblast via an AdipoR1 Receptor, AMPK, p38, and NF-κB Pathway
- Expanding role of AMPK in endocrinology
- Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle
- Identification of Phosphorylation Sites in AMP-activated Protein Kinase (AMPK) for Upstream AMPK Kinases and Study of Their Roles by Site-directed Mutagenesis*
- AMPK activation: a therapeutic target for type 2 diabetes?
- AMPK and Raptor: Matching Cell Growth to Energy Supply
- AMPK: Lessons from transgenic and knockout animals
- LKB1 and AMPK and the cancer-metabolism link – ten years after
- AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise
- GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK
- Exercise Increases Nuclear AMPK α2 in Human Skeletal Muscle
- LKB1 and AMPK maintain epithelial cell polarity under energetic stress
- Targeting the AMPK pathway for the treatment of Type 2 diabetes
- Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise
- Control of AMPK-related kinases by USP9X and atypical Lys29/Lys33-linked polyubiquitin chains
- Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity
- A Central Role for Neuronal AMP-Activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in High-Protein Diet–Induced Weight Loss
- Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation
- Chutes and Ladders: the search for protein kinases that act on AMPK
- AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2α in adipocytes
- AMPK and transcriptional regulation.
- Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca2+
- The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo
- AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function
- Rosiglitazone Reduces Glucose-Induced Oxidative Stress Mediated by NAD(P)H Oxidase via AMPK-Dependent Mechanism
- Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy
- Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways
- AMPK Activation Stimulates Myofibrillar Protein Degradation and Expression of Atrophy-Related Ubiquitin Ligases by Increasing FOXO Transcription Factors in C2C12 Myotubes
- Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells
- Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR‐γ signal pathways
- Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle
- Intrasteric control of AMPK via the γ1 subunit AMP allosteric regulatory site
- The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis
- Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR
- Dissociation of Bcl-2–Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes
- Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells
- Stimulation of AMP-Activated Protein Kinase (AMPK) Is Associated with Enhancement of Glut1-Mediated Glucose Transport
- AMPK: A Contextual Oncogene or Tumor Suppressor?
- AMPK-Dependent Phosphorylation of ULK1 Induces Autophagy
- Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERα negative MDA-MB-435 breast cancer model
- Deregulated MYC expression induces dependence upon AMPK-related kinase 5
- Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle
- The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator
- Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells
- Anti-obesity effects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte
- Targeting AMPK: A new therapeutic opportunity in breast cancer
- AMPK and autophagy get connected
- An energetic tale of AMPK–independent effects of metformin
- AMP-activated protein kinase (AMPK) control of fatty acid and glucose metabolism in the ischemic heart
- Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells
- AMPK‐mediated autophagy inhibits apoptosis in cisplatin‐treated tumour cells
- Agonist-modulated Regulation of AMP-activated Protein Kinase (AMPK) in Endothelial Cells
- Bryostatin Modulates Latent HIV-1 Infection via PKC and AMPK Signaling but Inhibits Acute Infection in a Receptor Independent Manner
- Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes
- Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK
- Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK
- Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators
- Adiponectin Represses Colon Cancer Cell Proliferation via AdipoR1- and -R2-Mediated AMPK Activation
- Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity
- Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy
- AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: Implications for obesity
- AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1
- In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis
- The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation
- The Crosstalk Between Nrf2 and AMPK Signal Pathways Is Important for the Anti-Inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked Mice
- Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway
- Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: role of ATGL, HSL, and AMPK
- AMPK– and p62/SQSTM1-dependent autophagy mediate Resveratrol-induced cell death in chronic myelogenous leukemia
- Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction
- Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by AMPK activation
- Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice
- Metformin inhibits TNF-α-induced IκB kinase phosphorylation, IκB-α degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation
- Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis
- The Role of AMPK and mTOR in Nutrient Sensing in Pancreatic β-Cells
- Ilex paraguariensis extract ameliorates obesity induced by high-fat diet: Potential role of AMPK in the visceral adipose tissue
- Sirtuin 1–Mediated Cellular Metabolic Memory of High Glucose Via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin
- Activation of the AMPK-FOXO3 Pathway Reduces Fatty Acid–Induced Increase in Intracellular Reactive Oxygen Species by Upregulating Thioredoxin
- AMPK: Regulating Energy Balance at the Cellular and Whole Body Levels
- Alpha‐lipoic acid decreases hepatic lipogenesis through adenosine monophosphate‐activated protein kinase (AMPK)‐dependent and AMPK‐independent pathways
- AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies
- AMP-activated Protein Kinase (AMPK) Negatively Regulates Nox4-dependent Activation of p53 and Epithelial Cell Apoptosis in Diabetes
- Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway
- Calorie Restriction: Is AMPK a Key Sensor and Effector?
- The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism
- LKB1 and AMPK Family Signaling: The Intimate Link Between Cell Polarity and Energy Metabolism
- Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase
- Neither LKB1 Nor AMPK Are the Direct Targets of Metformin
- Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1
- The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation
- Matched work high-intensity interval and continuous running induce similar increases in PGC-1α mRNA, AMPK, p38, and p53 phosphorylation in human skeletal muscle
- Metformin activates a duodenal AMPK–dependent pathway to lower hepatic glucose production in rats
- Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells
- p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin’s Effect on Food Intake
- AMPK modulates Hippo pathway activity to regulate energy homeostasis
- Etoposide Induces ATM-Dependent Mitochondrial Biogenesis through AMPK Activation
- Naringenin, a citrus flavonoid, increases muscle cell glucose uptake via AMPK
- Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice
- Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons
- Regulation and function of AMPK in physiology and diseases
- Resveratrol enhances GLUT‐4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium
- Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation
- Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK
- LKB1 and AMPK in cell polarity and division
- Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway
- AMPK functions as an adenylate charge-regulated protein kinase
- Metformin increases the PGC-1α protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo
- Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways
- AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation
- Regulation of the autophagy initiating kinase ULK1by nutrients: Roles of mTORC1 and AMPK
- Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection
- AMPK at the Nexus of Energetics and Aging
- Adiponectin directly improves endothelial dysfunction in obese rats through the AMPK–eNOS Pathway
- The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells
- β-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling
- Acetic acid activates hepatic AMPK and reduces hyperglycemia in diabetic KK-A(y) mice
- AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells
- Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway
- Histological evaluation of AMPK signalling in primary breast cancer
- AMPK Mediates the Initiation of Kidney Disease Induced by a High-Fat Diet
- Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle
- Resveratrol Induces Apoptosis in Chemoresistant Cancer Cells via Modulation of AMPK Signaling Pathway
- Exercise-Induced Irisin Secretion Is Independent of Age or Fitness Level and Increased Irisin May Directly Modulate Muscle Metabolism Through AMPK Activation
- The AMPK⁄SNF1⁄SnRK1 fuel gauge and energy regulator:structure, function and regulation
- Chlorogenic Acid Stimulates Glucose Transport in Skeletal Muscle via AMPK Activation: A Contributor to the Beneficial Effects of Coffee on Diabetes
- AMPK Activation Stimulates Autophagy and Ameliorates Muscular Dystrophy in the mdx Mouse Diaphragm
- 20(S)-Ginsenoside Rg3 Enhances Glucose-Stimulated Insulin Secretion and Activates AMPK
- Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes
- Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer
- Fenofibrate regulates retinal endothelial cell survival through the AMPK signal transduction pathway
- Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues
- Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK
- Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop
- AMPK: guardian of metabolism and mitochondrial homeostasis
- The AMPK-FoxO3A axis as a target for cancer treatment
- AMPK and Exercise: Glucose Uptake and Insulin Sensitivity
- PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis. signalling: protein kinases in glucose homeostasis
- AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment
- Prognostic Significance of AMPK Activation and Therapeutic Effects of Metformin in Hepatocellular Carcinoma
- AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis
- Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein
- Redox implications of AMPK-mediated signal transduction beyond energetic clues
- AMPK-independent induction of autophagy by cytosolic Ca2+ increase
- Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling
- AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance
- Therapeutics by Cytotoxic Metabolite Accumulation: Pemetrexed Causes ZMP Accumulation, AMPK Activation, and Mammalian Target of Rapamycin Inhibition
- Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity
- Metformin Blocks Melanoma Invasion and Metastasis Development in AMPK/p53-Dependent Manner
- Caffeine-induced Ca2+ release increases AMPK-dependent glucose uptake in rodent soleus muscle
- Adiponectin Blocks Interleukin-18-mediated Endothelial Cell Death via APPL1-dependent AMP-activated Protein Kinase (AMPK) Activation and IKK/NF-κB/PTEN Suppression
- Downregulation of AMPK Accompanies Leucine- and Glucose-Induced Increases in Protein Synthesis and Insulin Resistance in Rat Skeletal Muscle
- AMPK-mediated increase in myocardial long-chain fatty acid uptake critically depends on sarcolemmal CD36
- The regulation and function of mammalian AMPK‐related kinases
- Dissociation of AMPK activity and ACCβ phosphorylation in human muscle during prolonged exercise
- Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling
- Omega-3 Polyunsaturated Fatty Acids Antagonize Macrophage Inflammation via Activation of AMPK/SIRT1 Pathway
- A small molecule AMPK activator protects the heart against ischemia–reperfusion injury
- Metformin inhibitsP-glycoprotein expression via the NF-kB pathway andCRE transcriptional activitythrough AMPK activation
- AMPK activation attenuates S6K1, 4E-BP1, and eEF2 signaling responses to high-frequency electrically stimulated skeletal muscle contractions
- Involvement of AMPK Signaling Cascade in Capsaicin‐Induced Apoptosis of HT‐29 Colon Cancer Cells
- AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure
- The AMPK Inhibitor Compound C Is a Potent AMPK-Independent Antiglioma Agent
- Nitric oxide and AMPK cooperatively regulate PGC‐1α in skeletal muscle cells
- Osteogenesis and angiogenesis induced by porous β-CaSiO3/PDLGA composite scaffold via activation of AMPK/ERK1/2 and PI3K/Akt pathways
- Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2–mediated suppression of mTORC1
- Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue
- Coordinated time-dependent modulation of AMPK/Akt/mTOR signaling and autophagy controls osteogenic differentiation of human mesenchymal stem cells
- AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance
- AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure
- High molecular weight adiponectin activates AMPK and suppresses cytokine‐induced NF‐κB activation in vascular endothelial cells
- Metabolic Regulation of Neuronal Plasticity by the Energy Sensor AMPK
- 5-Aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK
- Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response
- C1q/TNF-Related Proteins, A Family of Novel Adipokines, Induce Vascular Relaxation Through the Adiponectin Receptor-1/AMPK/eNOS/Nitric Oxide Signaling Pathway
- AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner
- Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain
- AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3
- AMPKα1: A glucose sensor that controls CD8 T‐cell memory
- Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression
- Short‐term exercise training in humans reduces AMPK signalling during prolonged exercise independent of muscle glycogen
- Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53
- Metformin Inhibits Monocyte-to-Macrophage Differentiation via AMPK-Mediated Inhibition of STAT3 Activation: Potential Role in Atherosclerosis
- AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass
- The role of LKB1 and AMPK in cellular responses to stress and damage
- Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats
- Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle
- AMP-Activated Protein Kinase (AMPK) Molecular Crossroad for Metabolic Control and Survival of Neurons
- Functional analysis of Peutz–Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity
- AMPK activators: mechanisms of action and physiological activities
- LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training
- SIRT1 and AMPK in regulating mammalian senescence: A critical reviewand a working model
- Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: A crucial role of AMPK and mTOR pathways
- Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease
- Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1
- Cloning of a novel kinase (SIK) of the SNF1/AMPK family from high salt diet‐treated rat adrenal1
- AMPK
- Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells
- The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels
- Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain
- AMPK‐independent pathways regulate skeletal muscle fatty acid oxidation
- Adiponectin-Activated AMPK Stimulates Dephosphorylation of AKT through Protein Phosphatase 2A Activation
- Metformin Induces Apoptosis and Cell Cycle Arrest Mediated by Oxidative Stress, AMPK and FOXO3a in MCF-7 Breast Cancer Cells
- Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK
- Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism
- Glioma‐Initiating Cell Elimination by Metformin Activation of FOXO3 via AMPK
- Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP
- Diminished overload-induced hypertrophy in aged fast-twitch skeletal muscle is associated with AMPK hyperphosphorylation
- AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B
- Estradiol stimulates Akt, AMP-activated protein kinase (AMPK) and TBC1D1/4, but not glucose uptake in rat soleus
- Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates
- AMP-activated protein kinase (AMPK) beyond metabolism
- LKB1 is required for adiponectin-mediated modulation of AMPK–S6K axis and inhibition of migration and invasion of breast cancer cells
- Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival
- Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre‐activation of AMPK‐dependent autophagy
- Regulation of interplay between autophagy and apoptosis in the diabetic heart
- Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways
- Apelin Decreases Lipolysis via Gq, Gi, and AMPK-Dependent Mechanism
- EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells
- Cross-Talk between AMPK and mTOR in Regulating Energy Balance
- Acetylation of Yeast AMPK Controls Intrinsic Aging Independently of Caloric Restriction
- AMPK → ULK1 → Autophagy
- Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition
- The PPARβ/δ Activator GW501516 Prevents the Down-Regulation of AMPK Caused by a High-Fat Diet in Liver and Amplifies the PGC-1α-Lipin 1-PPARα Pathway Leading to Increased Fatty Acid Oxidation
- SIRT1 Acts as a Nutrient-sensitive Growth Suppressor and Its Loss Is Associated with Increased AMPK and Telomerase Activity
- AS160 phosphorylation is associated with activation of α2β2γ1- but not α2β2γ3-AMPK trimeric complex in skeletal muscle during exercise in humans
- AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner
- Resveratrol Modulates Tumor Cell Proliferation and Protein Translation via SIRT1-Dependent AMPK Activation
- IGF-1 phosphorylates AMPK-α subunit in ATM-dependent and LKB1-independent manner
- Dual Mechanisms Regulating AMPK Kinase Action in the Ischemic Heart
- Targeting AMPK for cancer prevention and treatment
- Resveratrol inhibits cell differentiation in 3T3-L1 adipocytes via activation of AMPK
- Inhibition of AMPK Catabolic Action by GSK3
- Effects of Metformin on Bovine Granulosa Cells Steroidogenesis: Possible Involvement of Adenosine 5′ Monophosphate-Activated Protein Kinase (AMPK)
- Interleukin-6 release from human skeletal muscle during exercise: relation to AMPK activity
- Metformin inhibits inflammatory response via AMPK–PTEN pathway in vascular smooth muscle cells
- AMP as a Low-Energy Charge Signal Autonomously Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation
- LKB1/AMPK/mTOR signaling pathway in hematological malignancies: From metabolism to cancer cell biology
- Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activity
- AICAR, an AMPK Activator, Has Protective Effects on Alcohol‐Induced Fatty Liver in Rats
- Adenosine Nucleotide Biosynthesis and AMPK Regulate Adult Life Span and Mediate the Longevity Benefit of Caloric Restriction in Flies
- The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling
- Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK
- Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells
- Troglitazone causes acute mitochondrial membrane depolarisation and an AMPK-mediated increase in glucose phosphorylation in muscle cells
- AMPK activation increases uncoupling protein-3 expressionand mitochondrial enzyme activities in rat muscle withoutfibre type transitions
- Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation
- CTRP9 Protein Protects against Myocardial Injury following Ischemia-Reperfusion through AMP-activated Protein Kinase (AMPK)-dependent Mechanism
- Cadmium induces autophagy through ROS-dependent activation of the LKB1–AMPK signaling in skin epidermal cells
- AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization
- Chronic AMPK activation evokes the slow, oxidative myogenic program and triggers beneficial adaptations in mdx mouse skeletal muscle
- Increased ∝2 Subunit–Associated AMPK Activity and PRKAG2Cardiomyopathy
- A Fluorescent Reporter of AMPK Activity and Cellular Energy Stress
- New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo
- AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: Implication of the cell survival in mitochondrial diseases
- AMPK-dependent Repression of Hepatic Gluconeogenesis via Disruption of CREB·CRTC2 Complex by Orphan Nuclear Receptor Small Heterodimer Partner
- CaM Kinase Kinase β-Mediated Activation of the Growth Regulatory Kinase AMPK Is Required for Androgen-Dependent Migration of Prostate Cancer Cells
- Identification and characterization of AMPK γ3 mutations in the pig
- AMPK signalling in health and disease
- Activation of Cannabinoid CB2 Receptor–Mediated AMPK/CREB Pathway Reduces Cerebral Ischemic Injury
- Metformin reverses multidrug resistance and epithelial–mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells
- Exercise-induced AMPK activity in skeletal muscle: Role in glucose uptake and insulin sensitivity
- Hypoxia-Induced Energy Stress Inhibits the mTOR Pathway by Activating an AMPK/REDD1 Signaling Axis in Head and Neck Squamous Cell Carcinoma
- Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway
- A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis
- Fenofibrate activates AMPK and increases eNOS phosphorylation in HUVEC
- Reduction of lipid accumulation in HepG2 Cells by luteolin is associated with activation of AMPK and Mitigation of oxidative stress
- AICAR potentiates ROS production induced by chronic high glucose: Roles of AMPK in pancreatic β-cell apoptosis
- Cannabinoid Receptor Stimulation Impairs Mitochondrial Biogenesis in Mouse White Adipose Tissue, Muscle, and Liver
- AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets
- Berberine reduces ischemia/reperfusion-induced myocardial apoptosis via activating AMPK and PI3K–Akt signaling in diabetic rats
- trans-(−)-ϵ-Viniferin Increases Mitochondrial Sirtuin 3 (SIRT3), Activates AMP-activated Protein Kinase (AMPK), and Protects Cells in Models of Huntington Disease
- Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes
- An Ezrin/Calpain/PI3K/AMPK/eNOSs1179 Signaling Cascade Mediating VEGF-Dependent Endothelial Nitric Oxide Production
- Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila
- Oxidative stress induces GLUT4 translocation by activation of PI3‐K/Akt and dual AMPK kinase in cardiac myocytes
- AMPK regulation of mouse oocyte meiotic resumption in vitro
- AMPK-Mediated Inhibition of mTOR Kinase Is Circumvented during Immediate-Early Times of Human Cytomegalovirus Infection
- Evidence for the involvement of CaMKII and AMPK in Ca2+-dependent signaling pathways regulating FA uptake and oxidation in contracting rodent muscle
- Adiponectin activation of AMPK disrupts leptin‐mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS‐3)
- AMPK-mediated regulation of transcription in skeletal muscle
- Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling
- Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations
- Nesfatin-1 Action in the Brain Increases Insulin Sensitivity Through Akt/AMPK/TORC2 Pathway in Diet-Induced Insulin Resistance
- Inhibitory crosstalk between ERK and AMPK in the growth and proliferation of cardiac fibroblasts
- Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells
- Metformin inhibition of mTORC1 activation, DNA synthesis and proliferation in pancreatic cancer cells: Dependence on glucose concentration and role of AMPK
- Hypoxia Leads to Na,K-ATPase Downregulation via Ca2+ Release-Activated Ca2+ Channels and AMPK Activation
- Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch
- AMPK exerts dual regulatory effects on the PI3K pathway
- Effect of exercise intensity and hypoxia on skeletal muscle AMPK signaling and substrate metabolism in humans
- AMPK‐dependent hormonal regulation of whole‐body energy metabolism
- The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2
- LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress
- CAPE (caffeic acid phenethyl ester) stimulates glucose uptake through AMPK (AMP-activated protein kinase) activation in skeletal muscle cells
- Regulation of hepatic metabolism by AMPK
- Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury
- The kinase triad, AMPK, mTORC1 and ULK1, maintains energy and nutrient homoeostasis
- Role of AMPK activation in oxidative cell damage: Implications for alcohol-induced liver disease
- Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR
- AMPK Reverses the Mesenchymal Phenotype of Cancer Cells by Targeting the Akt–MDM2–Foxo3a Signaling Axis
- AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells
- Differential effects of AMPK agonists on cell growth and metabolism
- AMPK activity and isoform protein expression are similar in muscle of obese subjects with and without type 2 diabetes
- AMPK: energy sensor and survival mechanism in the ischemic heart
- Resveratrol Protects HUVECs from Oxidized-LDL Induced Oxidative Damage by Autophagy Upregulation via the AMPK/SIRT1 Pathway
- Cross-talk between Two Essential Nutrient-sensitive Enzymes
O-GlcNAc TRANSFERASE (OGT) AND AMP-ACTIVATED PROTEIN KINASE (AMPK) - Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt
- Structural Insight into AMPK Regulation: ADP Comes into Play
- Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms
- MicroRNA-451 Exacerbates Lipotoxicity in Cardiac Myocytes and High-Fat Diet-Induced Cardiac Hypertrophy in Mice Through Suppression of the LKB1/AMPK Pathway
- The role of ATM in response to metformin treatment and activation of AMPK
- Glucagon-Like Peptide-1 (GLP-1) Analog Liraglutide Inhibits Endothelial Cell Inflammation through a Calcium and AMPK Dependent Mechanism
- Effects of metformin on breast cancer cell proliferation, the AMPK pathway and the cell cycle
- Epigallocatechin Gallate (EGCG) and Rutin Suppress the Glucotoxicity through Activating IRS2 and AMPK Signaling in Rat Pancreatic β Cells
- Regulatory Effect of the AMPK–COX‐2 Signaling Pathway in Curcumin‐Induced Apoptosis in HT‐29 Colon Cancer Cells
- A Redox-Dependent Mechanism for Regulation of AMPK Activation by Thioredoxin1 during Energy Starvation
- Targeting Energy Metabolic and Oncogenic Signaling Pathways in Triple-negative Breast Cancer by a Novel Adenosine Monophosphate-activated Protein Kinase (AMPK) Activator
- Compound C inhibits hypoxic activation of HIF‐1 independent of AMPK
- Compound K, Intestinal Metabolite of Ginsenoside, Attenuates Hepatic Lipid Accumulation via AMPK Activation in Human Hepatoma Cells
- Cocoa flavonoids improve insulin signalling and modulate glucose production via AKT and AMPK in HepG2 cells
- Dissecting the Dual Role of AMPK in Cancer: From Experimental to Human Studies
- AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells
- The metabolic “switch” AMPK regulates cardiac heparin-releasable lipoprotein lipase
- Quercetin suppresses HeLa cell viability via AMPK‐induced HSP70 and EGFR down‐regulation
- Perivascular fat-mediated vascular dysfunction and remodeling through the AMPK/mTOR pathway in high-fat diet-induced obese rats
- Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms
- AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity
- MicroRNA-451 regulates AMPK/mTORC1 signaling and fascin1 expression in HT-29 colorectal cancer
- PK Agonists Ameliorate Sodium and Fluid Transport and Inflammation in Cystic Fibrosis Airway Epithelial Cells
- MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer
- Regulation of Visceral and Subcutaneous Adipocyte Lipolysis by Acute AICAR‐induced AMPK Activation
- Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK
- AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy
- Glucose deprivation activates AMPK and induces cell death through modulation of Akt in ovarian cancer cells
- Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis
- The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation
- AMPK and p53 help cells through lean times
- Cinnamaldehyde Prevents Adipocyte Differentiation and Adipogenesis via Regulation of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) and AMP-Activated Protein Kinase (AMPK) Pathways
- Berberine inhibits platelet-derived growth factor-induced growth and migration partly through an AMPK-dependent pathway in vascular smooth muscle cells
- Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model
- Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia
- Adiponectin inhibits induction of TNF‐α/RANKL‐stimulated NFATc1 via the AMPK signaling
- Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARα and FGF21 transcripts in vivo
- Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells
- Insulin resistance due to nutrient excess
- AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells
- vFeedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans
- Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells
- Hypothalamic AMPK: a canonical regulator of whole-body energy balance
- Requirement for distinct vesicle-associated membrane proteins in insulin– and AMP-activated protein kinase (AMPK)-induced translocation of GLUT4 and CD36 in cultured cardiomyocytes
- Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism
- Thrombin and histamine stimulate endothelial nitric‐oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K‐Akt
- Activation of AMPK protects against hydrogen peroxide-induced osteoblast apoptosis through autophagy induction and NADPH maintenance: New implications for osteonecrosis treatment?
- AMPK-mediated GSK3β inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress
- Glucose-induced repression of PPARα gene expression in pancreatic β-cells involves PP2A activation and AMPK inactivation
- Citrus junos Tanaka Peel Extract Exerts Antidiabetic Effects via AMPK and PPAR-
both In Vitro and In Vivo in Mice Fed a High-Fat Diet - Aβ-induced formation of autophagosomes is mediated by RAGE-CaMKKβ-AMPK signaling
- Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1
- Upregulation of AMPK during cold exposure occurs via distinct mechanisms in brown and white adipose tissue of the mouse
- Sestrin2 Modulates AMPK Subunit Expression and Its Response to Ionizing Radiation in Breast Cancer Cells
- Skeletal muscle glucose uptake during contraction is regulated by nitric oxide and ROS independently of AMPK
- Carnosol, a Dietary Diterpene, Displays Growth Inhibitory Effects in Human Prostate Cancer PC3 Cells Leading to G2-Phase Cell Cycle Arrest and Targets the 5′-AMP-Activated Protein Kinase (AMPK) Pathway
- Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and β-amyloid in neurons
- Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade
- Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing to increased vulnerability in diabetic heart
- The antidiabetic effect of ginsenoside Rb2 via activation of AMPK
- Activated AMPK boosts the Nrf2/HO-1 signaling axis—A role for the unfolded protein response
- Intensified exercise training does not alter AMPK signaling in human skeletal muscle
- The DPP-4 inhibitor sitagliptin attenuates the progress of atherosclerosis in apolipoprotein-E-knockout mice via AMPK– and MAPK-dependent mechanisms
- Resistin induces insulin resistance by both AMPK-dependent and AMPK-independent mechanisms in HepG2 cells
- The LKB1-AMPK Pathway—Friend or Foe in Cancer?
- Olanzapine-Induced Hyperphagia and Weight Gain Associate with Orexigenic Hypothalamic Neuropeptide Signaling without Concomitant AMPK Phosphorylation
- Conserved regulatory elements in AMPK
- The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells
- Activation of AMP-activated protein kinase (AMPK) mediates plumbagin-induced apoptosis and growth inhibition in cultured human colon cancer cells
- Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension
- Antagonistic control of muscle cell size by AMPK and mTORC
- Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells
- Treatment of nonalcoholic fatty liver disease: role of AMPK
- The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
- SIRT1 Takes a Backseat to AMPK in the Regulation of Insulin Sensitivity by Resveratrol
- Structure of a CBS-domain pair from the regulatory [gamma]1 subunit of human AMPK in complex with AMP and ZMP
- AMPK and vasculoprotection
- ACa2+–calmodulin–eEF2K–eEF2 signalling cascade,but not AMPK, contributes to the suppression of skeletalmuscle protein synthesis during contractions
- Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression
- Structural basis of AMPK regulation by adenine nucleotides and glycogen
- Efficacy of sauchinone as a novel AMPK-activating lignan for preventing iron-induced oxidative stress and liver injury
- mTOR, AMPK, and GCN2 coordinate the adaptation of hepatic energy metabolic pathways in response to protein intake in the rat
- Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK)
- AMPK Regulates Circadian Rhythms in a Tissue– and Isoform-Specific Manner
- Changes in adiponectin, its receptors and AMPK activity in tissues of diet-induced diabetic miceModification des niveaux d’adiponectine, de ses récepteurs et de l’activité AMPK dans les tissus de souris diabétiques
- Curcumin Induces Autophagy via Activating the AMPK Signaling Pathway in Lung Adenocarcinoma Cells
- Mangiferin Decreases Plasma Free Fatty Acids through Promoting Its Catabolism in Liver by Activation of AMPK
- Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure
- AMPK activator, AICAR, inhibits palmitate-induced apoptosis in osteoblast
- Role of AMPK-mediated adaptive responses in human cells with mitochondrial dysfunction to oxidative stress
- Muscle cell depolarization induces a gain in surface GLUT4 via reduced endocytosis independently of AMPK
- Phosphorylation of BRAF by AMPK Impairs BRAF-KSR1 Association and Cell Proliferation
- Activation of AMP-activated protein kinase (AMPK) inhibits protein synthesis: a potential strategy to prevent the development of cardiac hypertrophy
- Resveratrol Attenuates Renal Hypertrophy in Early-Stage Diabetes by Activating AMPK
- A769662, a novel activator of AMP‐activated protein kinase, inhibits non‐proteolytic components of the 26S proteasome by an AMPK‐independent mechanism
- AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress
- AMPK: Sensing Glucose as well as Cellular Energy Status
- Differentiated mTOR but not AMPK signaling after strength vs endurance exercise in training‐accustomed individuals
- AMPK α1 Activation Is Required for Stimulation of Glucose Uptake by Twitch Contraction, but Not by H2O2, in Mouse Skeletal Muscle
- Pemetrexed Indirectly Activates the Metabolic Kinase AMPK in Human Carcinomas
- Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson’s disease
- AMPK: A cellular metabolic and redox sensor. A minireview
- Repurposing of Metformin and Aspirin by Targeting AMPK-mTOR and Inflammation for Pancreatic Cancer Prevention and Treatment
- Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases
- Mechanism of AMPK Suppression of LXR-dependent Srebp-1c Transcription
- Regulation of the renal-specific Na+–K+–2Cl− co-transporter NKCC2 by AMP-activated protein kinase (AMPK)
- Adiponectin protects against doxorubicin-induced cardiomyopathy by anti-apoptotic effects through AMPK up-regulation
- Ursolic Acid Inhibits Adipogenesis in 3T3-L1 Adipocytes through LKB1/AMPK Pathway
- Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways
- Adiponectin Inhibits Lipopolysaccharide-Induced Adventitial Fibroblast Migration and Transition to Myofibroblasts via AdipoR1-AMPK-iNOS Pathway
- Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain
- An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart
- Targeting AMPK for cardiac protection: Opportunities and challenges
- Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK
- Prolonged AMPK Activation Increases the Expression of Fatty Acid Transporters in Cardiac Myocytes and Perfused Hearts
- AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550
- Life-long caloric restriction elicits pronounced protection of the aged myocardium: A role for AMPK
- Inhibition of p38α unveils an AMPK-FoxO3A axis linking autophagy to cancer-specific metabolism
- Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle
- Palmitoleate Reverses High Fat-induced Proinflammatory Macrophage Polarization via AMP-activated Protein Kinase (AMPK)
- Structure and function of polarity-inducing kinase family MARK/Par-1 within the branch of AMPK/Snf1-related kinases
- Astragalus polysaccharides alleviates glucose toxicity and restores glucose homeostasis in diabetic states via activation of AMPK
- Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: Interference of AMPK/PGC-1α pathway
- Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway
- Mechanistic Insight into Control of CFTR by AMPK
- AMPK Structure and Regulation from Three Angles
- 20(S)-Ginsenoside Rg3-induced apoptosis in HT-29 colon cancer cells is associated with AMPK signaling pathway
- Adiponectin modulates carnitine palmitoyltransferase-1 through AMPK signaling cascade in rat cardiomyocytes
- AMPK: Evidence for an energy-sensing cytokinetic tumor suppressor
- Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction
- AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation
- AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia
- AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease
- Resistin Promotes Cardiac Hypertrophy via the AMP-activated Protein Kinase/Mammalian Target of Rapamycin (AMPK/mTOR) and c-Jun N-terminal Kinase/Insulin Receptor Substrate 1 (JNK/IRS1) Pathways
- Geminivirus Infection Up-Regulates the Expression of Two Arabidopsis Protein Kinases Related to Yeast SNF1- and Mammalian AMPK-Activating Kinases
- Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity
- Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice
- Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway
- Curcumin decreases renal triglyceride accumulation through AMPK–SREBP signaling pathway in streptozotocin-induced type 1 diabetic rats
- SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK
- Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis
- Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK–mTOR–SREBP signaling pathway
- An AMPK-Independent Signaling Pathway Downstream of the LKB1 Tumor Suppressor Controls Snail1 and Metastatic Potential
- Transitory Activation of AMPK at Reperfusion Protects the Ischaemic-Reperfused Rat Myocardium Against Infarction
- AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest
- Insulin and AMPK regulate FA translocase/CD36 plasma membrane recruitment in cardiomyocytes via Rab GAP AS160 and Rab8a Rab GTPase
- Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice
- Methyl succinate antagonises biguanide-inducedAMPK-activation and death of pancreaticb-cellsthrough restoration of mitochondrial electrontransfer
- Expanding roles for AMPK in skeletal muscle plasticity
- CTRP1 Protein Enhances Fatty Acid Oxidation via AMP-activated Protein Kinase (AMPK) Activation and Acetyl-CoA Carboxylase (ACC) Inhibition
- LKB1 and AMPK and the regulation of skeletal muscle metabolism
- Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function
- The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation and apoptosis via an AMPK/mTOR/P70S6K signaling pathway
- Pu-erh tea, green tea, and black tea suppresses hyperlipidemia, hyperleptinemia and fatty acid synthase through activating AMPK in rats fed a high-fructose diet
- Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser
- A-769662 activates AMPK β1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle
- AMPK in cardiovascular health and disease
- Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically‐obese db/db mice
- Characterization of the CaMKKβ–AMPK signaling complex
- Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems
- AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation
- Retinoic Acid Leads to Cytoskeletal Rearrangement through AMPK-Rac1 and Stimulates Glucose Uptake through AMPK-p38 MAPK in Skeletal Muscle Cells
- AMPK Activation by Oncogenesis Is Required to Maintain Cancer Cell Proliferation in Astrocytic Tumors
- AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect
- Antileukemic effects of AMPK activators on BCR-ABL–expressing cells
- Acute rosiglitazone treatment is cardioprotective against ischemia-reperfusion injury by modulating AMPK, Akt, and JNK signaling in nondiabetic mice
- AMPK at the crossroads of circadian clocks and metabolism
- AMPK regulates basal skeletal muscle capillarization andVEGF expression, but is not necessary for the angiogenicresponse to exercise
- Oxytocin stimulates glucose uptake in skeletal muscle cells through the calcium–CaMKK–AMPK pathway
- Anti-adipogenic effect of dioxinodehydroeckol via AMPK activation in 3T3-L1 adipocytes
- AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
- AMPK and Akt Determine Apoptotic Cell Death following Perturbations of One-Carbon Metabolism by Regulating ER Stress in Acute Lymphoblastic Leukemia
- AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation
- AMPK as a Therapeutic Target for Treating Metabolic Diseases
- AMP-activated protein kinase (AMPK) positively regulates osteoblast differentiation via induction of Dlx5-dependent Runx2 expression in MC3T3E1 cells
- Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways
- SIRT3 reduces lipid accumulation via AMPK activation in human hepatic cells
- Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK
- Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats
- Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway
- Suppression of AMPK Activation via S485 Phosphorylation by IGF-I during Hyperglycemia Is Mediated by AKT Activation in Vascular Smooth Muscle Cells
- Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression
- Ghrelin inhibits doxorubicin cardiotoxicity by inhibiting excessive autophagy through AMPK and p38-MAPK
- The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation
- Type 2 Diabetes Is Associated with Altered NF-κB DNA Binding Activity, JNK Phosphorylation, and AMPK Phosphorylation in Skeletal Muscle after LPS
- AMPK activation enhances PPARα activity to inhibit cardiac hypertrophy via ERK1/2 MAPK signaling pathway
- AMPK-mediated autophagy is a survival mechanism in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia
- AMPK activation is fiber type specific in human skeletal muscle: effects of exercise and short-term exercise training
- Control of glycogen synthase through ADIPOR1-AMPK pathway in renal distal tubules of normal and diabetic rats
- Structure and Dimerization of the Kinase Domain from Yeast Snf1, a Member of the Snf1/AMPK Protein Family
- Cytokine Regulation of AMPK signalling.
- Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells
- Role of AMPK in pancreatic beta cell function
- Regulation of caspase-6 and FLIP by the AMPK family member ARK5
- Genistein selectively potentiates arsenic trioxide‐induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species‐inducible protein kinases (p38‐MAPK, AMPK)
- AMPK inhibits cardiac hypertrophy by promoting autophagy via mTORC1
- AMP-activated kinase (AMPK)-generated signals in malignant melanoma cell growth and survival
- Ginsenoside Rc, an active component of Panax ginseng, stimulates glucose uptake in C2C12 myotubes through an AMPK-dependent mechanism
- AMP-activated protein kinase kinase: detection with recombinant AMPK α1 subunit
- Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis
- A high-fat diet decreases AMPK activity in multiple tissues in the absence of hyperglycemia or systemic inflammation in rats
- Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction
- Ginsenoside Rg1 Promotes Glucose Uptake Through Activated AMPK Pathway in Insulin‐resistant Muscle Cells
- Activation of AMP-activated protein kinase (AMPK) inhibits fatty acid synthesis in bovine mammary epithelial cells
- AMPK activators – potential therapeutics for metabolic and other diseases
- AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging
- AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell
- A Kinome RNAi Screen Identified AMPK as Promoting Poxvirus Entry through the Control of Actin Dynamics
- Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent
- Autophagy is not required to sustain exercise and PRKAA1/AMPK activity but is important to prevent mitochondrial damage during physical activity
- AICAR stimulates IL-6 production via p38 MAPK in cardiac fibroblasts in adult mice: A possible role for AMPK
- Genome-wide inhibitory impact of the AMPK activator metformin on [kinesins, tubulins, histones, auroras and polo-like kinases] M-phase cell cycle genes in human breast cancer cells
- The antidiabetic drug metformin: a pharmaceutical AMPK activator to overcome breast cancer resistance to HER2 inhibitors while decreasing risk of cardiomyopathy
- 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling
- Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells
- Adiponectin increases motility of human prostate cancer cells via adipoR, p38, AMPK, and NF‐κB pathways
- AMPK as a therapeutic target in renal cell carcinoma
- Ghrelin inhibits insulin secretion through the AMPK–UCP2 pathway inbcells
- AMP-activated protein kinase (AMPK) in the rock crab, Cancer irroratus: an early indicator of temperature stress
- Antiadipogenic Effect of Dietary Apigenin through Activation of AMPK in 3T3-L1 Cells
- Evidence for the role of AMPK in regulating PGC‐1 alpha expression and mitochondrial proteins in mouse epididymal adipose tissue
- Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity
- Simian Virus 40 Small T Antigen Activates AMPK and Triggers Autophagy To Protect Cancer Cells from Nutrient Deprivation
- Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside
- Irisin improves fatty acid oxidation and glucose utilization in type 2 diabetes by regulating the AMPK signaling pathway
- Central leptin action improves skeletal muscle AKT, AMPK, and PGC1α activation by hypothalamic PI3K-dependent mechanism
- Curcumin decreases oleic acid-induced lipid accumulation viaAMPK phosphorylation in hepato carcinoma cells
- Compound K Induces Apoptosis via CAMK-IV/AMPK Pathways in HT-29 Colon Cancer Cells
- AMPK and SNF1: Snuffing Out Stress
- Activation of AMPK by Pterostilbene Suppresses Lipogenesis and Cell-Cycle Progression in p53 Positive and Negative Human Prostate Cancer Cells
- Nutrient deprivation induces the Warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinase
- AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow
- Resveratrol Prevents Oxidative Stress-Induced Senescence and Proliferative Dysfunction by Activating the AMPK-FOXO3 Cascade in Cultured Primary Human Keratinocytes
- Activation of AMPK α- and γ-isoform complexes in the intact ischemic rat heart
- Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression
- Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk
- AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC
- AMPK activation is not critical in the regulation of muscle FA uptake and oxidation during low-intensity muscle contraction
- SIRT5 is under the control of PGC-1α and AMPK and is involved in regulation of mitochondrial energy metabolism
- Thyroid hormone (T3) rapidly activates p38 and AMPK in skeletal muscle in vivo
- Small-Molecule Activators of AMP-Activated Protein Kinase (AMPK), RSVA314 and RSVA405, Inhibit Adipogenesis
- AMPK involvement in endoplasmic reticulum stress and autophagy modulation after fatty liver graft preservation: a role for melatonin and trimetazidine cocktail
- Regulation of ploidy and senescence by the AMPK‐related kinase NUAK1
- Malonyl-CoA decarboxylase (MCD) is differentially regulated insubcellular compartments by 5¢AMP-activated protein kinase (AMPK)
- Green Tea Catechin Controls Apoptosis in Colon Cancer Cells by Attenuation of H2O2‐Stimulated COX‐2 Expression via the AMPK Signaling Pathway at Low‐Dose H2O2
- PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism
- Quantitative phosphoproteomics reveals the role of the AMPK plant ortholog SnRK1 as a metabolic master regulator under energy deprivation
- Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signaling
- AMPK and autophagy in glucose/glycogen metabolism
- Extracellular adenosine activates AMP-dependent protein kinase (AMPK)
- HCMV Targets the Metabolic Stress Response through Activation of AMPK Whose Activity Is Important for Viral Replication
- Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy
- Coenzyme Q10 suppresses oxLDL‐induced endothelial oxidative injuries by the modulation of LOX‐1‐mediated ROS generation via the AMPK/PKC/NADPH oxidase signaling pathway
- SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non–Small Cell Lung Cancers to Cisplatin and Doxorubicin
- Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?
- Insulin inhibits AMPK activity and phosphorylates AMPK Ser485/491 through Akt in hepatocytes, myotubes and incubated rat skeletal muscle
- LKB1/AMPK/mTOR Signaling Pathway in Non-small-cell Lung Cancer
- β‐elemene inhibited expression of DNA methyltransferase 1 through activation of ERK1/2 and AMPKα signalling pathways in human lung cancer cells: the role of Sp1
- A1 adenosine receptor signal and AMPK involving caspase-9/-3 activation are responsible for adenosine-induced RCR-1 astrocytoma cell death
- The In Vivo Antidiabetic Activity of Nigella sativa Is Mediated through Activation of the AMPK Pathway and Increased Muscle Glut4 Content
- Metformin Induced AMPK Activation, G0/G1 Phase Cell Cycle Arrest and the Inhibition of Growth of Esophageal Squamous Cell Carcinomas In Vitro and In Vivo
- Defining the Contribution of AMP-activated Protein Kinase (AMPK) and Protein Kinase C (PKC) in Regulation of Glucose Uptake by Metformin in Skeletal Muscle Cells
- Inhibition of Mutant GNAQ Signaling in Uveal Melanoma Induces AMPK-Dependent Autophagic Cell Death
- Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells
- Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPK-activating lignan in Saururus chinensis
- Activation of autophagy by globular adiponectin attenuates ethanol-induced apoptosis in HepG2 cells: Involvement of AMPK/FoxO3A axis
- Feeding long-chain n−3 polyunsaturated fatty acids during gestation increases intestinal glucose absorption potentially via the acute activation of AMPK
- Resveratrol activates AMPK and suppresses LPS-induced NF-κB-dependent COX-2 activation in RAW 264.7 macrophage cells
- The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: implication for Krabbe Disease
- Quercetin and its metabolites improve vessel function by inducing eNOS activity via phosphorylation of AMPK
- Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart
- Reactive oxygen species are produced at low glucose and contribute to the activation of AMPK in insulin-secreting cells
- Curcumin stimulates glucose uptake through AMPK‐p38 MAPK pathways in L6 myotube cells
- Cold-induced PGC-1α expression modulates muscle glucose uptake through an insulin receptor/Akt-independent, AMPK-dependent pathway
- Activated AMPK inhibits PPAR-α and PPAR-γ transcriptional activity in hepatoma cells
- AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA
- Neuronal Protein Tyrosine Phosphatase 1B Deficiency Results in Inhibition of Hypothalamic AMPK and Isoform-Specific Activation of AMPK in Peripheral Tissues
- The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression
- Hispidulin Sensitizes Human Ovarian Cancer Cells to TRAIL-Induced Apoptosis by AMPK Activation Leading to Mcl-1 Block in Translation
- AMPK controls epithelial Na+ channels through Nedd4-2 and causes an epithelial phenotype when mutated
- Chronic elevated calcium blocks AMPK-induced GLUT-4 expression in skeletal muscle
- Stabilization and activation of p53 downregulates mTOR signaling through AMPK in mantle cell lymphoma
- Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission
- Time course of GLUT4 and AMPK protein expression in human skeletal muscle during one month of physical training
- Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO‐dependent pathway
- Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate
- AMPK and the neuroendocrine regulation of appetite and energy expenditure
- Acute exercise activates AMPK and eNOS in the mouse aorta
- Baicalein induces autophagic cell death throughAMPK/ULK1 activation and downregulation of mTORC1complex components in human cancer cells
- Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy
- Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia
- Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK
- AMPK and metabolic adaptation by the heart to pressure overload
- New Strategies in Prostate Cancer: Targeting Lipogenic Pathways and the Energy Sensor AMPK
- miR451 and AMPK Mutual Antagonism in Glioma Cell Migration and Proliferation: A Mathematical Model
- Arsenic Inhibits Neurite Outgrowth by Inhibiting the LKB1–AMPK Signaling Pathway
- Metformin Activates AMPKthrough the Lysosomal Pathway
- Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms
- Phosphorylation of the insulin receptor by AMP-activated protein kinase (AMPK) promotes ligand-independent activation of the insulin signalling pathway in rodent muscle
- Ginsenoside Rg3 Reduces Lipid Accumulation with AMP-Activated Protein Kinase (AMPK) Activation in HepG2 Cells
- Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels
- Impaired adiponectin-AMPK signalling in insulin-sensitive tissues of hypertensive rats
- Chronic Caloric Restriction and Exercise Improve Metabolic Conditions of Dietary-Induced Obese Mice in Autophagy Correlated Manner without Involving AMPK
- AMPK Activators Suppress Cervical Cancer Cell Growth through Inhibition of DVL3 Mediated Wnt/β-Catenin Signaling Activity
- A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels
- Epigallocatechin-3-O-gallate (EGCG) attenuates FFAs-induced peripheral insulin resistance through AMPK pathway and insulin signaling pathway in vivo
- Endocrine-related cancers and the role of AMPK
- Salidroside ameliorates insulin resistance through activation of a mitochondria‐associated AMPK/PI3K/Akt/GSK3β pathway
- Resveratrol decreases fructose-induced oxidative stress, mediated by NADPH oxidase via an AMPK-dependent mechanism
- A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells
- A PPARγ, NF-κB and AMPK-Dependent Mechanism May Be Involved in the Beneficial Effects of Curcumin in the Diabetic db/db Mice Liver
- Berberine prevents nitric oxide-induced rat chondrocyte apoptosis and cartilage degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling
- AMPK Regulates ER Morphology and Function in Stressed Pancreatic β-Cells via Phosphorylation of DRP1
- LKB1, an upstream AMPK kinase, regulates glucose and lipid metabolism in cultured liver and muscle cells
- SnRK1 from Arabidopsis thaliana is an atypical AMPK
- Inhibition of AMPK signalling by doxorubicin: at the crossroads of the cardiac responses to energetic, oxidative, and genotoxic stress
- Berberine-induced apoptotic and autophagic death of HepG2 cells requires AMPK activation
- Sepsis and AMPK Activation by AICAR Differentially Regulate FoxO-1, -3 and -4 mRNA in Striated Muscle
- AMP-activated protein kinase (AMPK) cross-talks with canonical Wnt signaling via phosphorylation of β-catenin at Ser 552
- Metformin Plays a Dual Role in MIN6 Pancreatic β Cell Function through AMPK-dependent Autophagy
- Resveratrol inhibition of inducible nitric oxide synthase in skeletal muscle involves AMPK but not SIRT1
- Angiotensin II receptor blocker telmisartan enhances running endurance of skeletal muscle through activation of the PPAR‐δ/AMPK pathway
- Metformin Induces Apoptosis through AMPK-Dependent Inhibition of UPR Signaling in ALL Lymphoblasts
- Mitochondrial dysfunction and Parkinson disease: a Parkin–AMPK alliance in neuroprotection
- Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis
- Dietary Curcumin Ameliorates Aging-Related Cerebrovascular Dysfunction through the AMPK/Uncoupling Protein 2 Pathway
- Enhanced technique to measure proteins in single segments of human skeletal muscle fibers: fiber-type dependence of AMPK-α1 and -β1
- The α-subunit of AMPK is essential for submaximal contraction-mediated glucose transport in skeletal muscle in vitro
- Inhibitory cross-talkbetween the AMPK andERK pathways mediatesendoplasmic reticulumstress-induced insulinresistance in skeletal muscle
- Sestrin 2 and AMPK Connect Hyperglycemia to Nox4-Dependent Endothelial Nitric Oxide Synthase Uncoupling and Matrix Protein Expression
- AMPK activity is regulated by calcium-mediated protein phosphatase 2A activity
- AMPK Promotes Autophagy by Facilitating Mitochondrial Fission
- AMPK control of myocardial fatty acid metabolism fluctuates with the intensity of insulin-deficient diabetes
- MicroRNA‐455 regulates brown adipogenesis via a novel HIF1an‐AMPK‐PGC1α signaling network
- Altered Metabolism and Persistent Starvation Behaviors Caused by Reduced AMPK Function in Drosophila
- Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia
- AMPK Activation Ameliorates Alzheimer’s Disease-Like Pathology and Spatial Memory Impairment in a Streptozotocin-Induced Alzheimer’s Disease Model in Rats
- Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling
- Metformin induces Rab4 through AMPK and modulates GLUT4 translocation in skeletal muscle cells
- Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells
- Nitric oxide increases cyclic GMP levels, AMP-activated protein kinase (AMPK)α1-specific activity and glucose transport in human skeletal muscle
- Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of Raf-ERK-Nrf2 signaling and AMPK-independent pathways
- Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells
- AMPK activation protects cells from oxidative stress‐induced senescence via autophagic flux restoration and intracellular NAD+ elevation
- Metformin Regulates Glucose Transporter 4 (GLUT4) Translocation through AMP-activated Protein Kinase (AMPK)-mediated Cbl/CAP Signaling in 3T3-L1 Preadipocyte Cells
- P2X7 Integrates PI3K/AKT and AMPK-PRAS40-mTOR Signaling Pathways to Mediate Tumor Cell Death
- The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy
- Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDK1/cyclin B in SK-HEP-1 human hepatic cancer cells
- Effects of Exercise on AMPK Signaling and Downstream Components to PI3K in Rat with Type 2 Diabetes
- Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation
- ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway
- AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the Brain
- The changing AMPK expression profile in differentiatingmouse skeletal muscle myoblast cells helps conferincreasing resistance to apoptosis
- Folliculin Regulates AMPK-Dependent Autophagy and Metabolic Stress Survival
- Oxidative stress improves coronary endothelial function through activation of the pro-survival kinase AMPK
- A novel protective mechanism for mitochondrial aldehyde dehydrogenase (ALDH2) in type i diabetes-induced cardiac dysfunction: Role of AMPK-regulated autophagy
- Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice
- Xanthigen Suppresses Preadipocyte Differentiation and Adipogenesis through Down-regulation of PPARγ and C/EBPs and Modulation of SIRT-1, AMPK, and FoxO Pathways
- AMPK inhibits myoblast differentiation through a PGC-1α-dependent mechanism
- AMPK Enhances Insulin-Stimulated GLUT4 Regulation via Lowering Membrane Cholesterol
- AMPK agonist AICAR improves cognition and motor coordination in young and aged mice
- SPARC interacts with AMPK and regulates GLUT4 expression
- AMPK β subunits display isoform specific affinities for carbohydrates
- Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β
- A novel AMPK activator, WS070117, improves lipid metabolism discords in hamsters and HepG2 cells
- Resveratrol Induces Vascular Smooth Muscle Cell Differentiation through Stimulation of SirT1 and AMPK
- AMPK Activates Autophagy by Phosphorylating ULK1
- Mitotic kinase dynamics of the active form ofAMPK (Phospho-AMPKαThr172) in human cancercells
- Acute exercise does not cause sustained elevations in AMPK signaling or expression.
- The selected flavonol glycoside derived from Sophorae Flos improves glucose uptake and inhibits adipocyte differentiation via activation AMPK in 3T3-L1 cells
- Temozolomide induces autophagy via ATM‑AMPK‑ULK1 pathways in glioma
- Activation of AMPK by metformin inhibits TGF-β-induced collagen production in mouse renal fibroblasts
- Regulation of AMPK Activation by CD36 Links Fatty Acid Uptake to β-Oxidation
- Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex
- Dual cardiac contractile effects of the α2-AMPK deletion in low-flow ischemia and reperfusion
- Ultraviolet (UV) and Hydrogen Peroxide Activate Ceramide-ER Stress-AMPK Signaling Axis to Promote Retinal Pigment Epithelium (RPE) Cell Apoptosis
- AMPK binds to Sestrins and mediates the effect of exercise to increase insulin-sensitivity through autophagy
- AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis
- Metformin improves the angiogenic functions of endothelial progenitor cells via activating AMPK/eNOS pathway in diabetic mice
- PP2A Mediated AMPK Inhibition Promotes HSP70 Expression in Heat Shock Response
- AMPK-β1 subunit is a p53-independent stress responsive protein that inhibits tumor cell growth upon forced expression
- Metabolic roles of AMPK and metformin in cancer cells
- Delphinidin‐3‐glucoside protects human umbilical vein endothelial cells against oxidized low‐density lipoprotein‐induced injury by autophagy upregulation via the AMPK/SIRT1 signaling pathway
- Regulation of macroautophagy in ovarian cancer cells in vitro and in vivo by controlling Glucose regulatory protein 78 and AMPK
- The role of AMPK in controlling metabolism andmitochondrial biogenesis during exercise
- Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells
- A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis
- AMPK activation prevents excess nutrient-induced hepatic lipid accumulation by inhibiting mTORC1 signaling and endoplasmic reticulum stress response
- AMPK Activation by Metformin Suppresses Abnormal Extracellular Matrix Remodeling in Adipose Tissue and Ameliorates Insulin Resistance in Obesity
- The association of microtubules with tight junctions is promoted by cingulin phosphorylation by AMPK
- Compound C inhibits clonal expansion of preadipocytes by increasing p21 level irrespectively of AMPK inhibition
- Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer’s disease neuropathological deficits
- Role of AMPK in UVB-induced DNA damage repair and growth control
- AMPK regulates metabolism and survival in response to ionizing radiation
- Metformin attenuates pressure overload-induced cardiac hypertrophy via AMPK activation
- AMPK Phosphorylates Desnutrin/ATGL and Hormone-Sensitive Lipase To Regulate Lipolysis and Fatty Acid Oxidation within Adipose Tissue
- Oncogenic MAGEA-TRIM28 ubiquitin ligase downregulates autophagy by ubiquitinating and degrading AMPK in cancer
- Resveratrol attenuates high glucose-induced oxidative stress and cardiomyocyte apoptosis through AMPK
- Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes
- A combination of four active compounds alleviates cerebral ischemia–reperfusion injury in correlation with inhibition of autophagy and modulation of AMPK/mTOR and JNK pathways
- Lactoferrin increases 172ThrAMPK phosphorylation and insulin-induced p473SerAKT while impairing adipocyte differentiation
- The anti-diabetic AMPK activator AICAR reduces IL-6 and IL-8 in human adipose tissue and skeletal muscle cells
- Coenzyme Q10 increases the fatty acid oxidation through AMPK-mediated PPARα induction in 3T3-L1 preadipocytes
- AMPK: An emerging target for modification of injury-induced pain plasticity
- Nutritional status modulates plasma leptin, AMPK and TOR activation, and mitochondrial biogenesis: Implications for cell metabolism and growth in skeletal muscle of the fine flounder
- Autophagic cell death induced by resveratrol depends on the Ca2+/AMPK/mTOR pathway in A549 cells
- Nootkatone, a characteristic constituent of grapefruit, stimulates energy metabolism and prevents diet-induced obesity by activating AMPK
- Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization
- Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells
- UVB irradiation regulates Cox‐2 mRNA stability through AMPK and HuR in human keratinocytes
- Targeting AMPK in the treatment of malignancies
- Proteomic Profiling Identifies Pathways Dysregulated in Non-small Cell Lung Cancer and an Inverse Association of AMPK and Adhesion Pathways with Recurrence
- Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function
- Regulation of Orai1/STIM1 by the kinases SGK1 and AMPK
- Rosemary (Rosmarinus officinalis L.) Extract Regulates Glucose and Lipid Metabolism by Activating AMPK and PPAR Pathways in HepG2 Cells
- AMPK activation by glucagon-like peptide-1 prevents NADPH oxidase activation induced by hyperglycemia in adult cardiomyocytes
- Activation of AMPK is necessary for killing cancer cells and sparing cardiac cells
- AMPK and ACC phosphorylation: Effect of leptin, muscle fibre type and obesity
- Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity
- Capsaicin stimulates glucose uptake in C2C12 muscle cells via the reactive oxygen species (ROS)/AMPK/p38 MAPK pathway
- Micro-RNA-195 and -451 Regulate the LKB1/AMPK Signaling Axis by Targeting MO25
- PPAR-γ and AMPK – Advantageous targets for myocardial ischemia/reperfusion therapy
- Radiosensitization of Pancreatic Cancer Cells by Metformin through the AMPK Pathway
- Acetylcholine Mediates AMPK-Dependent Autophagic Cytoprotection in H9c2 Cells During Hypoxia/Reoxygenation Injury
- Contraction-mediated phosphorylation of AMPK is lower in skeletal muscle of adenylate kinase-deficient mice
- Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation
- Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer
- Dihydromyricetin improves skeletal muscle insulin resistance by inducing autophagy via the AMPK signaling pathway
- Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson’s Disease
- Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice
- The role of AMPK/mTOR/S6K1 signaling axis in mediating the physiological process of exercise-induced insulin sensitization in skeletal muscle of C57BL/6 mice
- The peroxisome proliferator-activated receptor β/δ (PPARβ/δ) agonist GW501516 prevents TNF-α-induced NF-κB activation in human HaCaT cells by reducing p65 acetylation through AMPK and SIRT1
- Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver
- Discovery and SAR development of thienopyridones: A class of small molecule AMPK activators
- L‐cysteine and hydrogen sulfide increase PIP3 and AMPK/PPARγ expression and decrease ROS and vascular inflammation markers in high glucose treated human U937 monocytes
- AMPK Regulates Metabolic Actions of Glucocorticoids by Phosphorylating the Glucocorticoid Receptor through p38 MAPK
- Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis
- A PRKAG2 mutation causes biphasic changes in myocardial AMPK activity and does not protect against ischemia
- Irisin, a Novel Myokine, Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK
- Involvement of adipokines, AMPK, PI3K and the PPAR signaling pathways in ovarian follicle development and cancer
- Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway
- Immunometabolism of AMPK in insulin resistance and atherosclerosis
- AMPK activation inhibits the expression of HIF-1α induced by insulin and IGF-1
- Exercise-induced metabolic fluctuations influence AMPK,p38-MAPK and CaMKII phosphorylation in human skeletal muscle
- The LKB1/AMPK polarity pathway
- AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?
- Niacin bound chromium treatment induces myocardial Glut-4 translocation and caveolar interaction via Akt, AMPK and eNOS phosphorylation in streptozotocin induced diabetic rats after ischemia-reperfusion injury
- Nilotinib Induces Autophagy in Hepatocellular Carcinoma through AMPK Activation
- Isoproterenol instigates cardiomyocyte apoptosis and heart failure via AMPK inactivation-mediated endoplasmic reticulum stress
- Resveratrol Enhances the Antitumor Effects of Temozolomide in Glioblastoma via ROS‐dependent AMPK‐TSC‐mTOR Signaling Pathway
- LITAF and TNFSF15, two downstream targets of AMPK, exert inhibitory effects on tumor growth
- NAD Blocks High Glucose Induced Mesangial Hypertrophy via Activation of the Sirtuins-AMPK-mTOR Pathway
- Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans
- Regulation of AMPK by the Ubiquitin Proteasome System
- Anti-obesity effect of sulfated glucosamine by AMPK signal pathway in 3T3-L1 adipocytes
- Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle
- Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK
- Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy
- 4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK/AKT-mTOR and JNK pathways
- 4‐Hydroxyderricin and xanthoangelol from Ashitaba (Angelica keiskei) suppress differentiation of preadiopocytes to adipocytes via AMPK and MAPK pathways
- CCCP induces autophagy in an AMPK-independent manner
- Crosstalk between AMPK activation and angiotensin II‐induced hypertrophy in cardiomyocytes: the role of mitochondria
- AMPK: A metabolic checkpoint that regulates thegrowth of EGFR activated glioblastomas
- Cardioprotective effect of adiponectin is partially mediated by its AMPK-independent antinitrative action
- Low concentration of metformin induces a p53-dependent senescence in hepatoma cells via activation of the AMPK pathway
- Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice
- ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK
- α2-AMPK activity is not essential for an increase in fatty acid oxidation during low-intensity exercise
- Downregulation of microRNA-451 in non-alcoholic steatohepatitis inhibits fatty acid-induced proinflammatory cytokine production through the AMPK/AKT pathway
- Activation of AMPK Enhances Neutrophil Chemotaxis and Bacterial Killing
- LKB1 and AMPK differentially regulate pancreatic β-cell identity
- The protective effect of trimetazidine on myocardial ischemia/reperfusion injury through activating AMPK and ERK signaling pathway
- Oxidative stress activates AMPK in cultured cells primarilyby increasing cellular AMP and/or ADP
- AMPK regulates histone H2B O-GlcNAcylation
- Tanshinone IIA Induces Autophagic Cell Death via Activation of AMPK and ERK and Inhibition of mTOR and p70 S6K in KBM‐5 Leukemia Cells
- SNF4Aγ, the Drosophila AMPK γ subunit is required for regulation of developmental and stress-induced autophagy
- Sulforaphane induced adipolysis via hormone sensitive lipase activation, regulated by AMPK signaling pathway
- Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice
- Leptin promotes KATP channel trafficking by AMPK signaling in pancreatic β-cells
- Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight
- Resveratrol prevents norepinephrine induced hypertrophy in adult rat cardiomyocytes, by activating NO-AMPK pathway
- AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival
- Eicosapentaenoic Acid Protects against Palmitic Acid-Induced Endothelial Dysfunction via Activation of the AMPK/eNOS Pathway
- Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK
- Belinostat-induced apoptosis and growth inhibition in pancreatic cancer cells involve activation of TAK1-AMPK signaling axis
- Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662
- Caffeic Acid Derivatives Inhibit the Growth of Colon Cancer: Involvement of the PI3-K/Akt and AMPK Signaling Pathways
- Ketone bodies alter dinitrophenol-induced glucose uptake through AMPK inhibition and oxidative stress generation in adult cardiomyocytes
- AMPK regulates autophagy by phosphorylating BECN1 at threonine 388
- Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1
- Insulin stimulation of glucose uptake fails to decrease palmitate oxidation in muscle if AMPK is activated
- Activation of AMPK by berberine promotes adiponectin multimerizationin 3T3-L1 adipocytes
- Exercise‐stimulated interleukin‐15 is controlled by AMPK and regulates skin metabolism and aging
- AMPK isoform expression in the normal and failing hearts
- Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis
- Dialogue Between LKB1 and AMPK: A Hot Topic at the Cellular Pole
- AMP-Activated Kinase AMPK Is Expressed in Boar Spermatozoa and Regulates Motility
- OxLDL induces endothelial dysfunction and death via TRAF3IP2: Inhibition by HDL3 and AMPK activators
- Globular adiponectin induces LKB1/AMPK-dependent glucose uptake via actin cytoskeleton remodeling.
- Adiponectin attenuates angiotensin II-induced oxidative stress in renal tubular cells through AMPK and cAMP-Epac signal transduction pathways
- Calcineurin suppresses AMPK-dependent cytoprotective autophagy in cardiomyocytes under oxidative stress
- CB1 receptor mediates the effects of glucocorticoids on AMPK activity in the hypothalamus.
- Fenofibrate lowers lipid accumulation in myotubes by modulating the PPARα/AMPK/FoxO1/ATGL pathway
- FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway
- Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells
- Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK
- Deficiency in AMPK attenuates ethanol-induced cardiac contractile dysfunction through inhibition of autophagosome formation
- GLP-1 analogue improves hepatic lipid accumulation by inducing autophagy via AMPK/mTOR pathway
- Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels
- Glycolysis Inhibition Sensitizes Non–Small Cell Lung Cancer with T790M Mutation to Irreversible EGFR Inhibitors via Translational Suppression of Mcl-1 by AMPK Activation
- Suppression of 5′-Nucleotidase Enzymes Promotes AMP-activated Protein Kinase (AMPK) Phosphorylation and Metabolism in Human and Mouse Skeletal Muscle
- Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate
- Prior AICAR Stimulation Increases Insulin Sensitivity in Mouse Skeletal Muscle in an AMPK-Dependent Manner
- Quercetin enhances hypoxia-mediated apoptosis via direct inhibition of AMPK activity in HCT116 colon cancer
- Choreography of AMPK activation
- Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling
- AMPK Activators as Novel Therapeutics for Type 2 Diabetes
- High CO2 Levels Cause Skeletal Muscle Atrophy via AMP-activated Kinase (AMPK), FoxO3a Protein, and Muscle-specific Ring Finger Protein 1 (MuRF1)
- Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR
- Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro
- LKB1 Regulates Lipid Oxidation During Exercise Independently of AMPK
- Palmitate Causes Endoplasmic Reticulum Stress and Apoptosis in Human Mesenchymal Stem Cells: Prevention by AMPK Activator
- Folliculin Controls Lung Alveolar Enlargement and Epithelial Cell Survival through E-Cadherin, LKB1, and AMPK
- Metformin has adenosine-monophosphate activated protein kinase (AMPK)-independent effects on LPS-stimulated rat primary microglial cultures
- Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase
- The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels
- AMPK – Activated Protein Kinase and its Role in Energy Metabolism of the Heart
- Acrp30 inhibits leptin-induced metastasis by downregulating the JAK/STAT3 pathway via AMPK activation in aggressive SPEC-2 endometrial cancer cells
- Metabolic energy sensors (AMPK and SIRT1), protein carbonylation and cardiac failure as biomarkers of thermal stress in an intertidal limpet: linking energetic allocation with environmental temperature during aerial emersion
- Exendin-4 directly improves endothelial dysfunction in isolated aortas from obese rats through the cAMP or AMPK–eNOS pathways
- The double-edged sword of AMPK signaling in cancer and its therapeutic implications
- IFI16 Induction by Glucose Restriction in Human Fibroblasts Contributes to Autophagy through Activation of the ATM/AMPK/p53 Pathway
- Curcumin suppresses colon cancer cell invasion via AMPK-induced inhibition of NF-κB, uPA activator and MMP9
- Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells
- Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells
- Ghrelin induces cell migration through GHS‐R, CaMKII, AMPK, and NF‐κB signaling pathway in glioma cells
- LKB1 and AMPK: central regulators of lymphocyte metabolism and function
- Fructose-Induced Hypothalamic AMPK Activation Stimulates Hepatic PEPCK and Gluconeogenesis due to Increased Corticosterone Levels
- AMP-activated protein kinase response to contractionsand treatment with the AMPK activator AICAR in youngadult and old skeletal muscle
- LKB1 and AMPK regulate synaptic remodeling in old age
- Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway
- Role of AMPK in skeletal muscle gene adaptation in relation to exercise
- Endothelium-dependent vasorelaxation to the AMPK activator AICAR is enhanced in aorta from hypertensive rats and is NO and EDCF dependent
- Resistin promotes tumor metastasis by down-regulation of miR-519d through the AMPK/p38 signaling pathway in human chondrosarcoma cells
- AMPK α2 subunit is involved in platelet signaling, clot retraction, and thrombus stability
- Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo
- Inhibition of the LKB1–AMPK pathway by the Epstein–Barr virus‐encoded LMP1 promotes proliferation and transformation of human nasopharyngeal epithelial cells
- Docosahexaenoic Acid Induces Cell Death in Human Non-Small Cell Lung Cancer Cells by Repressing mTOR via AMPK Activation and PI3K/Akt Inhibition
- Metformin-stimulated AMPK-α1 promotes microvascular repair in acute lung injury
- Visfatin is expressed in human granulosa cells: regulation by metformin through AMPK/SIRT1 pathways and its role in steroidogenesis
- Modification of Endothelial Nitric Oxide Synthase through AMPK after Experimental Subarachnoid Hemorrhage
- IRE1-Dependent Activation of AMPK in Response to Nitric Oxide
- Glucose promotes cell proliferation, glucose uptake and invasion in endometrial cancer cells via AMPK/mTOR/S6 and MAPK signaling
- Adiponectin activates the AMPK signaling pathway to regulate lipid metabolism in bovine hepatocytes
- Leptin Regulates KATP Channel Trafficking in Pancreatic β-Cells by a Signaling Mechanism Involving AMP-activated Protein Kinase (AMPK) and cAMP-dependent Protein Kinase (PKA)
- Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK
- HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer
- AMPK-Mediated Lysosome Biogenesis in Lung Cancer Growth
- Cardiac myocyte-specific expression of beta3-adrenergic receptors sustains AMPK activation and glucose uptake while reducing hypertrophy following pressure overload
- AMPK activation protects against diet-induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue
- Galectins control MTOR and AMPK in response to lysosomal damage to induce autophagy
- Hyperosmotic Stress Initiates AMPK-Independent Autophagy and AMPK– and Autophagy-Independent Depletion of Thioredoxin 1 and Glyoxalase 2 in HT22 Nerve Cells
- Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver
- AMPK hierarchy: a matter of space and time