Curcumin Curcumin ameliorates arterial dysfunction and oxidative stress with aging Curcumin and aging Curcumin Extends Life Span, Improves Health Span, and Modulates the Expression of Age-Associated aging Genes in Drosophila melanogaster Dietary Curcumin ameliorates aging-related cerebrovascular dysfunction through the AMPK/uncoupling protein 2 pathway Curcumin induces heme oxygenase‐1 in normal human skin fibroblasts through redox […]
Celastrol (God Vine) 532 Priming of Stem Cells With celastrol to Enhance Survival for Cell Therapy A lipidomics investigation into the intervention of celastrol in experimental colitis A mechanistic overview of triptolide and celastrol, natural products from Tripterygium wilfordii Hook F A new mechanism of inhibition of IL-1β secretion by celastrol through the NLRP3
Carnosine Carnosine, the protective, anti-aging peptide The roles of carnosine in aging of skeletal muscle and in neuromuscular diseases Would carnosine or a carnivorous diet help suppress aging and associated pathologies? aging, proteotoxicity, mitochondria, glycation, NAD+ and carnosine: possible inter-relationships and resolution of the oxygen paradox Carnosine and taurine treatments diminished brain oxidative stress and
Alkaloids from Acorus gramineus rhizomes and their biological activity Alpha-asarone, a major component of Acorus gramineus, attenuates corticosterone-induced anxiety-like behaviours via modulating TrkB signaling process Anti-Candida properties of asaronaldehyde of Acorus gramineus rhizome and three structural isomers Determination of Essential Oils by Headspace Solid-Phase Microextraction-GC/MS: Quality Control of Acorus gramineus Solander Identification of Acorus gramineus,
SHIPPING APRIL 15TH!!! ZOMBIE CELL KILLER News Articles: Both Senolytic Molecules Are Inhibitors Of Particular Members Of The Bcl-2 Family Of Apoptosis Regulatory Proteins And Have Distinct Pharmacokinetic Profiles. ‘One Of The Most Important Aging Discoveries Ever’ 100 Is The New 60: The Transformation Of Healthcare 12 Innovations That Could Make Reverse Aging A
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Andrographis Paniculata Hepatoprotective activity of Andrographolide from Andrographis paniculata against carbontetrachloride. Andrographolide protects rat hepatocytes against paracetamol-induced damage In vitro and in vivo anti-inflammatory effects of Andrographolide. Hepatoprotective activity of Andrographolide against galactosamine & paracetamol intoxication in rats. A phase I trial of Andrographolide in HIV positive patients and normal volunteers Andrographolide, a potential cancer
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MDM2 antagonists attenuate the senescence-associated secretory phenotype Processes that have been linked to aging and cancer include an inflammatory milieu driven by senescent cells. Senescent cells lose the ability to divide, essentially irreversibly, and secrete numerous proteases, cytokines and growth factors, termed the senescence-associated secretory phenotype (SASP). Senescent cells that lack p53 tumor suppressor function
Prevention of premature senescence requires JNK activation Premature senescence is considered as a cellular defense mechanism to prevent tumorigenesis. Although recent evidences show that c-Jun N-terminal kinase (JNK) is involved in the senescence process, the mechanism for this regulation is not fully understood. Here, we examined the role of JNK in premature senescence of tumor
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… : VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR–PI3K–AKT pathway (oncogene,(2018), 37, 41,(5585 … … and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation … and hormonal aspects of 6 human neoplasias with special emphasis on
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JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age A hallmark of aging is chronic sterile inflammation, which is closely associated with frailty and age-related diseases. We found that senescent fat progenitor cells accumulate in adipose tissue with aging and acquire a senescence-associated secretory phenotype (SASP), with increased production of proinflammatory
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