DISEASE & DISORDERS

INFLAMMATION & CANCER

042P Prospective Study Evaluating White Adipose Tissue Inflammation And Clinicopathologic Features In Endometrial Cancer 109 The Wolf In Sheep’S Clothing: The Role Of Interleukin-6 In Immunity, Inflammation And Cancer 120 Airway Epithelial Control Of Pseudomonas Aeruginosa Infection In … 113Pcould A Systemic Inflammation Response Index (Siri) Predict Overall Survival (Os) In Metastatic Pancreatic Cancer (Pc)? […]

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CYTOKINES IN PAIN, INFLAMMATION & AGING

127. B2-And B3-Adrenergic Receptors Drive The Development Of Comt-Dependent PAIN By Increasing Release Of No And Innate Immune CYTOKINES 2078: Ngf And Tnf-Α Contribute To Oral Cancer PAIN By Regulating Pro-Inflammatory CYTOKINES A Cohort Study Comparing The Serum Levels Of Pro-Or Anti-Inflammatory CYTOKINES In Patients With Lumbar Radicular PAIN And Healthy Subjects A Feasibility Study

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SASP & ADIPOSE TISSUE

Exercise prevents diet-induced cellular senescence in adipose tissue Physiological aging: links among adipose tissue dysfunction, diabetes, and frailty Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses Aging and adipose tissue: potential interventions for diabetes and regenerative medicine Roles of chemokine ligand-2 (CXCL2) and neutrophils in influencing endothelial

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TELOMERE SHORTENING & PREMATURE AGING

A branching process model of telomere shortening A continuous correlation between oxidative stress and telomere shortening in fibroblasts A Critical Role for Pin2/TRF1 in ATM-dependent Regulation INHIBITION OF Pin2/TRF1 FUNCTION COMPLEMENTS telomere shortening, RADIOSENSITIVITY, AND THE G2/M CHECKPOINT DEFECT OF ATAXIA-TELANGIECTASIA CELLS A G-quadruplex-interactive agent, telomestatin (SOT-095), induces telomere shortening with apoptosis and enhances chemosensitivity

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PREMATURE SENESCENCE

Premature Senescence ”Senescence is more than merely a cell division clock that regulates the proliferative lifespan of normal cells. “Premature” senescence is an active cytostaticprogram that is triggered in response to proliferative or genotoxic stress, such as the expression of strong oncogenes, tumor suppressor loss, exposure to DNA damage, and reactivation of tumor suppressor pathways.

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ONCOGENE ACTIVATION

… : VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR–PI3K–AKT pathway (oncogene,(2018), 37, 41,(5585 … … and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation … and hormonal aspects of 6 human neoplasias with special emphasis on

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MTOR : THE RAPID AGING PATHWAY

MTOR: The Rapid Aging  Pathway  “The mammalian target of rapamycin(mTOR), also known as the mechanistic target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene.[5][6][7] mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases.[8] mTOR links with other proteins

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