Adapting proteostasis for disease intervention Biological and chemical approaches to diseases of proteostasis deficiency Proteostasis and aging The proteostasis network and its decline in ageing The biology of proteostasis in aging and disease Pathways of cellular proteostasis in aging and disease Aging as an event of proteostasis collapse Proteostasis impairment in protein-misfolding and-aggregation diseases Quality […]
Review of genetic and epigenetic alterations in hepatocarcinogenesis epigenetic alterations in aging Genetic and epigenetic alterations in colon cancer epigenetic alterations in colorectal cancer: emerging biomarkers Induction of epigenetic alterations by dietary and other environmental factors Cause and consequences of genetic and epigenetic alterations in human cancer epigenetic alterations in Alzheimer’s disease Genetic and epigenetic
EPIGENETIC ALTERATIONS Read More »
Hematopoietic Stem cell exhaustion impacted by p18INK4C and p21Cip1/Waf1 in opposite manners mTOR mediates Wnt-induced epidermal Stem cell exhaustion and aging Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis The Polycomb group gene Ezh2 prevents hematopoietic Stem cell exhaustion Relationships between Stem cell exhaustion , tumour suppression and ageing
STEM CELL EXHAUSTION Read More »
Telomerase gene therapy ameliorates the effects of neurodegeneration associated to short telomeres in mice AGING of Immune System Sex-specific components of frailty in C57BL/6 mice Long live the queen, the king and the commoner? Transcript expression differences between old and young in the termite Cryptotermes secundus Ten years of brainage as a neuroimAGING biomarker of
HALLMARKS OF AGING Read More »
EXTRACELLULAR GLYCATION crosslinks: prospects for removal Attenuation of EXTRACELLULAR MATRIX accumulation in diabetic nephropathy by the advanced GLYCATION end product cross-link BREAKER ALT-711 via a protein kinase C-α … Advanced GLYCATION endproduct CROSSLINKING in the cardiovascular system Advanced GLYCATION End Product Cross‐Linking: Pathophysiologic Role and Therapeutic Target in Cardiovascular Disease GLYCATION end-product cross-link BREAKER reduces
EXTRACELLULAR MATRIX STIFFENING Read More »
SGLT inhibitors in management of diabetes Structural selectivity of human SGLT inhibitors A novel approach to control hyperglycemia in type 2 diabetes: Sodium glucose co-transport (SGLT) inhibitors. Systematic review and meta-analysis of randomized … SGLT inhibitors as antidiabetic agents: a comprehensive review International consensus on risk management of diabetic ketoacidosis in patients with type 1
SGLT2 INHIBITION FOR LIFESPAN EXTENSION Read More »
Advanced glycation end products Key players in skin aging? Abstract Aging is the progressive accumulation of damage to an organism over time leading to disease and death. Aging research has been very intensive in the last years aiming at characterizing the pathophysiology of aging and finding possibilities to fight age-related diseases. Various theories of aging
ADVANCED GLYCATION END PRODUCTS (AGES) Read More »
SHIPPING APRIL 15TH!!! ZOMBIE CELL KILLER News Articles: Both Senolytic Molecules Are Inhibitors Of Particular Members Of The Bcl-2 Family Of Apoptosis Regulatory Proteins And Have Distinct Pharmacokinetic Profiles. ‘One Of The Most Important Aging Discoveries Ever’ 100 Is The New 60: The Transformation Of Healthcare 12 Innovations That Could Make Reverse Aging A
SENESCENT CELLS, SASP & SENOLYTICS Read More »
A branching process model of telomere shortening A continuous correlation between oxidative stress and telomere shortening in fibroblasts A Critical Role for Pin2/TRF1 in ATM-dependent Regulation INHIBITION OF Pin2/TRF1 FUNCTION COMPLEMENTS telomere shortening, RADIOSENSITIVITY, AND THE G2/M CHECKPOINT DEFECT OF ATAXIA-TELANGIECTASIA CELLS A G-quadruplex-interactive agent, telomestatin (SOT-095), induces telomere shortening with apoptosis and enhances chemosensitivity
TELOMERE SHORTENING & PREMATURE AGING Read More »
