SCIENCE

BCL-XL

  Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL Senescent cells, formed in response to physiological and oncogenic stresses, facilitate protection from tumourigenesis and aid in tissue repair. However, accumulation of such cells in tissues contributes to age-related pathologies. Resistance of senescent cells to apoptotic stimuli may contribute to their accumulation, yet […]

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BCL-W

3-Hydroxy-3′, 4′-Dimethoxyflavone Suppresses Bcl-W-Induced Invasive Potentials And Stemness In Glioblastoma Multiforme 44 Over-Expression Of Microrna-122 (Mir-122) Induces Apoptosis By Targeting Cycling1 And Bcl-W Genes In Vitro A Novel Bcl-2/Bcl-Xl/Bcl-W Inhibitor Abt-737 As Therapy In Multiple Myeloma A Retrograde Neuronal Survival Response: Target-Derived Neurotrophins Regulate Mef2D And Bcl-W Abstract A3: Bcl-W-Induced Invasive Pathways In Gastric Cancer

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BECLIN-1 & AUTOPHAGY

A Distinct Pattern of Beclin-1 Staining Helps Distinguish Sessile Serrated Adenomas A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1 A novel role of Beclin-1, cytokinetic abscission A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic A pivotal role of FOS-mediated BECN1/Beclin

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STAT3

A cell-permeable STAT3 SH2 domain mimetic inhibitor of STAT3 activation inhibits growth of human breast tumor xenografts A cell-permeable STAT3 SH2 domain mimetic inhibits STAT3 activation and induces antitumor cell effects in vitro A low-molecular-weight compound discovered through virtual database screening inhibits STAT3 function in breast cancer cells A membrane penetrating peptide aptamer inhibits STAT3

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INFLAMMATION & DEPRESSION

    A biological pathway linking inflammation and depression: activation of indoleamine 2, 3-dioxygenase A human in vitro model to investigate the effects of inflammation on adult hippocampal neurogenesis in the context of depression A new paradigm for depression in new mothers: the central role of inflammation and how breastfeeding and anti-inflammatory treatments protect maternal

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INFLAMMATION & ANXIETY

… Adolescent Patients with Juvenile Idiopathic Arthritis, Anxiety and Mood Predicts Function Whereas Life Event Stressors in the Older Adolescent Predicts inflammation … association of somatic and cognitive symptoms of depression and Anxiety with inflammation: findings from the Netherlands Study of Depression and Anxiety … … depression after percutaneous coronary intervention are associated with decreased

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INFLAMMATION & CANCER

042P Prospective Study Evaluating White Adipose Tissue Inflammation And Clinicopathologic Features In Endometrial Cancer 109 The Wolf In Sheep’S Clothing: The Role Of Interleukin-6 In Immunity, Inflammation And Cancer 120 Airway Epithelial Control Of Pseudomonas Aeruginosa Infection In … 113Pcould A Systemic Inflammation Response Index (Siri) Predict Overall Survival (Os) In Metastatic Pancreatic Cancer (Pc)?

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CENTENARIANS

(Cd45Ra+) And Memory (Cd45R0+) Cells Between Cd4+ And Cd8+ Lymphocytes-T In Humans-A Study From Newborns To Centenarians 166: Out-Of-Hospital Cardiac Arrest (Ohca) In Centenarians In Japan 56Demographics Of Centenarians Admitted Through Medical Receiving In Raigmore Hospital A Baseline Investigation Of Independence Among 100 Community-Dwelling Centenarians In Turkey A Census‐Based Comparison Of Centenarians In New Zealand

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SASP & ADIPOSE TISSUE

Exercise prevents diet-induced cellular senescence in adipose tissue Physiological aging: links among adipose tissue dysfunction, diabetes, and frailty Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses Aging and adipose tissue: potential interventions for diabetes and regenerative medicine Roles of chemokine ligand-2 (CXCL2) and neutrophils in influencing endothelial

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