EXTENDS LIFESPAN

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  1. Overexpression of Atg5 in mice activates autophagy and extends lifespan
  2. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
  3. Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
  4. Dietary deprivation extends lifespan in Caenorhabditis elegans
  5. An antidepressant that extends lifespan in adult Caenorhabditis elegans
  6. rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice
  7. Increased fidelity of protein synthesis extends lifespan
  8. Loss of pregnancy‐associated plasma protein A extends lifespan in mice
  9. The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet
  10. 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila
  11. JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila
  12. Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice
  13. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
  14. D-beta-hydroxybutyrate extends lifespan in C. elegans
  15. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
  16. Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status
  17. Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+
  18. PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
  19. Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice
  20. Restriction of amino acids extends lifespan in Drosophila melanogaster
  21. Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice
  22. Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
  23. Preventing age-related decline of gut compartmentalization limits microbiota dysbiosis and extends lifespan
  24. Dietary restriction extends lifespan through metabolic regulation of innate immunity
  25. Glycine supplementation extends lifespan of male and female mice
  26. Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice
  27. Lonicera japonica extends lifespan and healthspan in Caenorhabditis elegans
  28. Reduced circulating insulin enhances insulin sensitivity in old mice and extends lifespan
  29. Roux‐en‐Y gastric bypass enhances energy expenditure and extends lifespan in diet‐induced obese rats
  30. New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis
  31. The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
  32. The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila
  33. Single-dose CRISPR–Cas9 therapy extends lifespan of mice with Hutchinson–Gilford progeria syndrome
  34. Deletion of the Mitochondrial Superoxide Dismutase sod-2 extends lifespan in Caenorhabditis elegans
  35. Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila
  36. Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model
  37. The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease
  38. The phytochemical, EGCG, extends lifespan by reducing liver and kidney function damage and improving age‐associated inflammation and oxidative stress in healthy …
  39. Royalactin extends lifespan of Caenorhabditis elegans through epidermal growth factor signaling
  40. Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome
  41. Methionine restriction extends lifespan in progeroid mice and alters lipid and bile acid metabolism
  42. Chemical activation of a food deprivation signal extends lifespan
  43. Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice
  44. Aspirin Inhibits Oxidant Stress, Reduces Age-Associated Functional Declines, and extends lifespan of Caenorhabditis elegans
  45. Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan
  46. Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria
  47. Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson’s disease model
  48. Arginase-II deficiency extends lifespan in mice
  49. Silymarin extends lifespan and reduces proteotoxicity in C. elegans Alzheimer’s model
  50. Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice
  51. Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan
  52. Mobilization‐based transplantation of young‐donor hematopoietic stem cells extends lifespan in mice
  53. The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice
  54. Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis
  55. An isocaloric moderately high-fat diet extends lifespan in male rats and Drosophila
  56. Overexpression of frataxin in the mitochondria increases resistance to oxidative stress and extends lifespan in Drosophila
  57. Sodium rutin extends lifespan and health span in mice including positive impacts on liver health
  58. Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer’s disease
  59. Lamotrigine extends lifespan but compromises health span in Drosophila melanogaster
  60. Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice
  61. Protocatechuic acid extends lifespan and increases stress resistance in Caenorhabditis elegans
  62. Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis
  63. Chicoric Acid Is an Antioxidant Molecule That Stimulates AMP Kinase Pathway in L6 Myotubes and extends lifespan in Caenorhabditis elegans
  64. Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans
  65. PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila
  66. Phosphatidylcholine extends lifespan via DAF-16 and reduces amyloid-beta-induced toxicity in Caenorhabditis elegans
  67. Panax notoginseng polysaccharide increases stress resistance and extends lifespan in Caenorhabditis elegans
  68. Dietary nitrite extends lifespan and prevents age-related locomotor decline in the fruit fly
  69. L-Theanine extends lifespan of adult Caenorhabditis elegans
  70. Rebaudioside A enhances resistance to oxidative stress and extends lifespan and healthspan in Caenorhabditis elegans
  71. Drosophila insulin‐like peptide‐6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin‐like peptide‐2 from the brain
  72. Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK
  73. Dietary Restriction extends lifespan in Wild-Derived Populations of Drosophila melanogaster
  74. The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat, and extends lifespan of Caenorhabditis elegans
  75. Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan
  76. S100A9 extends lifespan in insulin deficiency
  77. Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans
  78. The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO
  79. Vitamin E extends lifespan in the short-lived rotifer Asplanchna brightwelli
  80. Prohibitin depletion extends lifespan of a TORC2/SGK‐1 mutant through autophagy and the mitochondrial UPR
  81. Withania somnifera root extract extends lifespan of Caenorhabditis elegans
  82. Supplemental cellular protection by a carotenoid extends lifespan via Ins/IGF-1 signaling in Caenorhabditis elegans
  83. Ginsenoside extract from ginseng extends lifespan and health span in Caenorhabditis elegans
  84. Genetic reduction of mTOR extends lifespan in a mouse model of Hutchinson‐Gilford Progeria syndrome
  85. Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan
  86. Genetic inhibition of an ATP synthase subunit extends lifespan in C. elegans
  87. Near-infrared light increases ATP, extends lifespan and improves mobility in aged Drosophila melanogaster
  88. Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model …
  89. Purple sweet potato extract extends lifespan by activating autophagy pathway in male drosophila melanogaster
  90. A novel antioxidant peptide purified from defatted round scad (Decapterus maruadsi) protein hydrolysate extends lifespan in Caenorhabditis elegans
  91. Grape skin extract improves muscle function and extends lifespan of a Drosophila model of Parkinson’s disease through activation of mitophagy
  92. A deuterohemin peptide extends lifespan and increases stress resistance in Caenorhabditis elegans
  93. Pyrroloquinoline quinone enhances the resistance to oxidative stress and extends lifespan upon DAF-16 and SKN-1 activities in C. elegans
  94. Rhodiola rosea extends lifespan and improves stress tolerance in silkworm, Bombyx mori
  95. Maintenance of protein homeostasis in glia extends lifespan in C. elegans
  96. N-Acetylcysteine extends lifespan of Drosophila via modulating ROS scavenger gene expression
  97. … red wine consumption increases the expression of longevity-associated genes in controlled human populations and extends lifespan in Drosophila melanogaster
  98. Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice
  99. Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases
  100. The absence of a mitochondrial genome in rho0 yeast cells extends lifespan independently of retrograde regulation
  101. Verapamil extends lifespan in Caenorhabditis elegans by inhibiting calcineurin activity and promoting autophagy
  102. A reduction in age-enhanced gluconeogenesis extends lifespan
  103. Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy
  104. Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species
  105. An antidiabetic polyherbal phytomedicine confers stress resistance and extends lifespan in Caenorhabditis elegans
  106. Cyclin‐dependent kinase inhibition limits glomerulonephritis and extends lifespan of mice with systemic lupus
  107. Carnitine promotes recovery from oxidative stress and extends lifespan in C. elegans
  108. Emodin extends lifespan of Caenorhabditis elegans through insulin/IGF-1 signaling pathway depending on DAF-16 and SIR-2.1
  109. PBT2 reduces toxicity in a C. elegans model of polyQ aggregation and extends lifespan, reduces striatal atrophy and improves motor performance in the R6/2 mouse …
  110. The Yang-tonifying herbal medicine cynomorium songaricum extends lifespan and delays aging in drosophila
  111. 17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex
  112. Resveratrol extends lifespan and preserves glia but not neurons of the Nothobranchius guentheri optic tectum
  113. Metolazone upregulates mitochondrial chaperones and extends lifespan in Caenorhabditis elegans
  114. Genistein from Vigna angularis extends lifespan in Caenorhabditis elegans
  115. Sesamin extends lifespan through pathways related to dietary restriction in Caenorhabditis elegans
  116. MicroRNA-455-3p improves synaptic, cognitive functions and extends lifespan: Relevance to Alzheimer’s disease
  117. … of Streblus asper leaves protects against glutamate-induced toxicity in HT22 hippocampal neuronal cells and extends lifespan of Caenorhabditis elegans
  118. Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster
  119. Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice
  120. Korean red ginseng tonic extends lifespan in D. melanogaster
  121. Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster
  122. TORC 1‐mediated sensing of chaperone activity alters glucose metabolism and extends lifespan
  123. As predicted by hyperfunction theory, rapamycin treatment during development extends lifespan
  124. Astragalus polysaccharide extends lifespan via mitigating endoplasmic reticulum stress in the silkworm, Bombyx mori
  125. Echinacoside, a phenylethanoid glycoside from Cistanche deserticola, extends lifespan of Caenorhabditis elegans and protects from Aβ-induced toxicity
  126. Cocoa improves age-associated health and extends lifespan in C. elegans
  127. IgG3 deficiency extends lifespan and attenuates progression of glomerulonephritis in MRL/lprmice
  128. Over-expression of human clusterin increases stress resistance and extends lifespan in Drosophila melanogaster
  129. Early-stage treatment with Withaferin A reduces levels of misfolded superoxide dismutase 1 and extends lifespan in a mouse model of amyotrophic lateral …
  130. S‐adenosyl‐L‐homocysteine extends lifespan through methionine restriction effects
  131. A high-fat jelly diet restores bioenergetic balance and extends lifespan in the presence of motor dysfunction and lumbar spinal cord motor neuron loss in TDP …
  132. A nutritional supplement containing lactoferrin stimulates the immune system, extends lifespan, and reduces amyloid β peptide toxicity in Caenorhabditis elegans
  133. Minocycline treatment increases resistance to oxidative stress and extends lifespan in Drosophila via FOXO
  134. Sonneradon A extends lifespan of Caenorhabditis elegans by Modulating Mitochondrial and IIS Signaling Pathways
  135. Overexpression of metallothionein-I, a copper-regulating protein, attenuates intracellular copper dyshomeostasis and extends lifespan in a mouse model of …
  136. Concentrated fish oil (Lovaza®) extends lifespan and attenuates kidney disease in lupus-prone short-lived (NZBxNZW) F1 mice
  137. Caloric restriction extends lifespan of mothers at the expense of offspring survival in a predatory mite (Neoseiulus cucumeris)
  138. Inhibition of histone acetyltransferase GCN5 extends lifespan in both yeast and human cell lines
  139. Bark extract of the amazonian tree Endopleura uchi (Humiriaceae) extends lifespan and enhances stress resistance in Caenorhabditis elegans
  140. Experimentally reduced insulin/IGF‐1 signaling in adulthood extends lifespan of parents and improves Darwinian fitness of their offspring
  141. Rapamycin treatment during development extends lifespan and healthspan
  142. Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila
  143. Activation of autophagy attenuates motor deficits and extends lifespan in a C. elegans model of ALS
  144. Human IGF1 extends lifespan and enhances resistance to Plasmodium falciparum infection in the malaria vector Anopheles stephensi
  145. Translational control of gene expression by eIF2 modulates proteostasis and extends lifespan
  146. Dimethyl sulfide protects against oxidative stress and extends lifespan via a methionine sulfoxide reductase A‐dependent catalytic mechanism
  147. Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function
  148. Expression of the dystrophin isoform Dp116 preserves functional muscle mass and extends lifespan without preventing dystrophy in severely dystrophic mice
  149. Traditional tonifying polyherbal infusion, Jatu-Phala-Tiga, exerts antioxidant activities and extends lifespan of Caenorhabditis elegans
  150. Neuron-specific overexpression of core clock genes improves stress-resistance and extends lifespan of Drosophila melanogaster
  151. Ambient temperature reduction extends lifespan via activating cellular degradation activity in an annual fish (Nothobranchius rachovii)
  152. Hypoxia extends lifespan of Brachionus manjavacas (Rotifera)
  153. Intermittent exposure to fluorescent light extends lifespan of human diploid fibroblasts in culture
  154. Neuronal‐specific proteasome augmentation via Prosβ5 overexpression extends lifespan and reduces age‐related cognitive decline
  155. Ilex paraguariensis extends lifespan and Increases an Ability to Resist Environmental Stresses in Drosophila
  156. FOXM1 delays senescence and extends lifespan
  157. Glycerol extends lifespan of Brachionus manjavacas (Rotifera) and protects against stressors
  158. Inhibition of a eukaryotic initiation factor (eIF2Bδ,/F11A3.2) during adulthood extends lifespan in Caenorhabditis elegans
  159. Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in Caenorhabditis elegans via inhibiting OSM-9
  160. Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice
  161. Reduced expression of alpha‐1,2‐mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans
  162. Lentinan extends lifespan and increases oxidative stress resistance through DAF-16 and SKN-1 pathways in Caenorhabditis elegans
  163. Hepatic lipase deficiency delays atherosclerosis, myocardial infarction, and cardiac dysfunction and extends lifespan in SR-BI/apolipoprotein E double knockout mice
  164. Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse …
  165. A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice
  166. Transition state analogue of MTAP extends lifespan of APCMin/+ mice
  167. Astaxanthin extends lifespan via altered biogenesis of the mitochondrial respiratory chain complex III
  168. Inhibition of GIP signaling extends lifespan without caloric restriction
  169. IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis
  170. Mutation of daf‐2 extends lifespan via tissue‐specific effectors that suppress distinct life‐limiting pathologies
  171. Rejuvenation of the disposable soma: repeated injury extends lifespan in an asexual annelid
  172. Reduced neuronal expression of ribose‐5‐phosphate isomerase enhances tolerance to oxidative stress, extends lifespan, and attenuates polyglutamine toxicity in …
  173. Astragaloside IV extends lifespan of Caenorhabditis elegans by Improving Age-Related Functional Declines and Triggering Antioxidant Responses
  174. The collagen-derived compound collagen tripeptide induces collagen expression and extends lifespan via a conserved p38 mitogen-activated protein kinase cascade
  175. Chinese liquor extract attenuates oxidative damage in HepG2 cells and extends lifespan of Caenorhabditis elegans
  176. DhHP-6 extends lifespan of Caenorhabditis elegans by enhancing nuclear translocation and transcriptional activity of DAF-16
  177. A critical review of the evidence that metformin is a putative anti-aging drug that enhances healthspan and extends lifespan
  178. Gemals, a new drug candidate, extends lifespan and improves electromyographic parameters in a rat model of amyotrophic lateral sclerosis
  179. Identification of a sustainable two-plant diet that effectively prevents age-related metabolic syndrome and extends lifespan in aged mice
  180. Liangyi Gao extends lifespan and exerts an antiaging effect in Caenorhabditis elegans by modulating DAF-16/FOXO
  181. Reevaluation of whether a soma–to–germ-line transformation extends lifespan in Caenorhabditis elegans
  182. Loss of NDG‐4 extends lifespan and stress resistance in Caenorhabditis elegans
  183. Autophagy extends lifespan via vacuolar acidification
  184. Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans
  185. Oleuropein Enhances Stress Resistance and extends lifespan via Insulin/IGF-1 and SKN-1/Nrf2 Signaling Pathway in Caenorhabditis elegans
  186. Genetic perturbation of key central metabolic genes extends lifespan in Drosophila and affects response to dietary restriction
  187. Jujube (Ziziphus Jujuba Mill.) fruit feeding extends lifespan and increases tolerance to environmental stresses by regulating aging-associated gene expression in …
  188. A mid-life crisis for aging theory: from yeast to mice, limiting food intake slows aging and extends lifespan. Activators of the sirtuins, enzymes famously linked to this …
  189. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
  190. Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans
  191. PAK1-deficiency/down-regulation reduces brood size, activates HSP16. 2 gene and extends lifespan in Caenorhabditis elegans
  192. Syntaxin 4 overexpression ameliorates effects of aging and high-fat diet on glucose control and extends lifespan
  193. Streptococcus thermophilus extends lifespan through activation of DAF-16-mediated antioxidant pathway in Caenorhabditis elegans
  194. The neuroprotector benzothiazepine CGP37157 extends lifespan in C. elegans worms
  195. Enhancing mask activity in dopaminergic neurons extends lifespan in flies
  196. Knockdown expression of eukaryotic initiation factor 5 C-terminal domain containing protein extends lifespan in Drosophila melanogaster
  197. Cur2004-8, a synthetic curcumin derivative, extends lifespan and modulates age-related physiological changes in Caenorhabditis elegans
  198. S-allylmercapto-N-acetylcysteine protects against oxidative stress and extends lifespan in Caenorhabditis elegans
  199. Short-term enhancement of motor neuron synaptic exocytosis during early aging extends lifespan in Caenorhabditis elegans
  200. Loss of miR-83 extends lifespan and affects target gene expression in an age-dependent manner in Caenorhabditis elegans
  201. Alternative NADH dehydrogenase extends lifespan and increases resistance to xenobiotics in Drosophila
  202. A C-terminal truncated mutation of spr-3 gene extends lifespan in Caenorhabditis elegans
  203. Knock-down of odr-3 and ife-2 additively extends lifespan and healthspan in C. elegans
  204. Ethanol extends lifespan of the rotifer Brachionus plicatilis
  205. Increased Akt signaling in the fat body of Anopheles stephensi extends lifespan and increases lifetime fecundity through modulation of insulin-like peptides
  206. Potassium restriction boosts vacuolar acidity and extends lifespan in yeast
  207. A steroid hormone that extends the lifespan of Caenorhabditis elegans
  208. Consumption of a low glycaemic index diet in late life extends lifespan of Balb/c mice with differential effects on DNA damage
  209. 2-SeCD treatment extends lifespan, improves healthspan and enhances resistance to stress in Caenorhabditis elegans
  210. Rapamycin additively extends lifespan in short-and long-lived lines of the nematode Caenorhabditis remanei
  211. Degradation of alpha-synuclein by dendritic cell factor 1 delays neurodegeneration and extends lifespan in Drosophila
  212. Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan
  213. Enhancing autophagy by redox regulation extends lifespan in Drosophila
  214. Glucose extends lifespan through enhanced intestinal barrier integrity in Drosophila
  215. Rapamycin extends maximal lifespan in cancer-prone mice
  216. Dietary Glycine Supplementation extends lifespan of Genetically Heterogeneous Mice
  217. Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
  218. 10-Hydroxy-2-decenoic acid, the major lipid component of royal jelly, extends the lifespan of Caenorhabditis elegans through dietary restriction and target of …
  219. Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK
  220. Valproic acid extends Caenorhabditis elegans lifespan
  221. Hyperactivation of the proteasome core particle in Caenorhabditis elegans protects against proteotoxic stress and extends lifespan
  222. Osh6 overexpression extends the lifespan of yeast by increasing vacuole fusion
  223. Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans
  224. Downregulation of EDTP in glial cells suppresses polyglutamine protein aggregates and extends lifespan in Drosophila melanogaster
  225. Enhanced proteasome degradation extends Caenorhabditis elegans lifespan and alleviates aggregation-related pathologies
  226. A genetic model of methionine restriction extends Drosophila health-and lifespan
  227. Systemic delivery of rAAV6-microdystrophin preserves muscle function and extends lifespan in a murine model of severe muscular dystrophy
  228. ENA-A actimineral resource A extends lifespan associated with antioxidant mechanism in SMP30 knockout mice
  229. Overexpression of Fatty-Acid-𝜷-Oxidation-Related Genes extends the lifespan of Drosophila melanogaster
  230. Transition state analogue of MTAP extends lifespan of APCMin/+ mice
  231. Crocus sativus L. protects against SDS‑induced intestinal damage and extends lifespan in Drosophila melanogaster
  232. PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila
  233. Anti-aging effects of Ketanserin; Ketanserin extends lifespan in female drosophila, inhibits cellular senescence and promotes wound healing in-vitro
  234. LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice
  235. Lindera obtusiloba extends lifespan of Caenorhabditis elegans
  236. Correction: PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila
  237. Inhibition of retrotransposition improves health and extends lifespan of SIRT6 knockout mice
  238. Fructose extends lifespan and Reduces Intestinal Fat Deposition in Caenorhabditis elegans
  239. Ras inhibition by trametinib treatment in Drosophila attenuates gut pathology in females and extends lifespan in both sexes
  240. Author Correction: IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis
  241. Commentary: Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans
  242. Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans
  243. eIF2B extends lifespan through inhibition of the integrated stress response
  244. Valproic ACID extends lifespan of the Zebrafish Model of CLN2 Disease (Late Infantile Neuronal Ceroid Lipofuscinosis)
  245. Dietary Restriction extends lifespan through Metabolic Regulation of Innate Immunity
  246. Overexpression of protein carboxyl methyltransferase extends lifespan in Drosophila melanogaster
  247. Antioxidant extends lifespan
  248. d-Allulose, a stereoisomer of d-fructose, extends Caenorhabditis elegans lifespan through a dietary restriction mechanism: A new candidate dietary restriction mimetic
  249. Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer’s disease.
  250. … of rheumatoid arthritis. Nat. Med. (2005) 11:936-943, and BARBER DF, BARTOLOMÉ A, HERNANDEZ C et al.: PI3Kg inhibition blocks glomerulonephritis and extends lifespan in a mouse …
  251. INCREASE IN HSP25 extends lifespan AND IMPROVES RESPONSE TO TAU TOXICITY THROUGH A CELL, NON-AUTONOMOUS MECHANISM
  252. Hepatocyte Transplantation (HTx) extends lifespan, Increases Branched Chain a-Keto Acid Dehydrogenase (BCKDH) Activity, and Improves Neurotransmitter and …
  253. Systemic Administration of Telomerase RNA Reverses Vascular Senescence and extends lifespan in Progeria Mice
  254. ZOLEDRONATE extends lifespan AND HEALTHSPAN IN VIVO
  255. Ophiopogon japonicus herbal tea ameliorates oxidative stress and extends lifespan in caenorhabditis elegans
  256. Lithium extends lifespan and Slows Brain Aging
  257. NEURONAL-SPECIFIC PROTEASOME AUGMENTATION VIA extends lifespan AND REDUCES AGE-RELATED NEURODEGENERATION
  258. Celecoxib extends C. elegans lifespan via inhibition of insulin‐like signaling but not cyclooxygenase‐2 activity
  259. Downregulation of the tyrosine degradation pathway extends Drosophila lifespan
  260. Inhibition of lipid peroxidation during the reproductive period extends the lifespan of Caenorhabditis elegans
  261. REGULATION OF GLUCOSE STORAGE extends lifespan AND PROMOTES HEALTHSPAN
  262. Prohibitin depletion extends lifespan of a TORC2/SGK-1 mutant through autophagy
  263. No evidence that wine drinking extends lifespan
  264. Drinking Chamomile Tea extends lifespan
  265. Use of stable isotopes to examine how dietary restriction extends Drosophila lifespan
  266. Royalactin extends lifespan of C. elegans through EGF signaling
  267. Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins
  268. A small molecule norathyriol extends lifespan in association with mitochondrial function in C. elegans
  269. Supplementation with elenocysteine extends lifespan and modulates age-related physiological alterations in C. elegans
  270. Chicoric Acid Promotes Glucose Uptake and extends lifespan
  271. Enzyme role found for aging gene: two labs independently discover mechanism for how Sir2 extends lifespan.(Hot Papers)
  272. Metformin extends C. elegans lifespan through lysosomal pathway
  273. jouvence, a new small nucleolar RNA required in the gut extends lifespan in Drosophila
  274. Long live the Queen-Royalactin extends lifespan of C. elegans through epidermal growth factor (EGF) signaling
  275. β‐Guanidinopropionic acid extends the lifespan of Drosophila melanogaster via an AMP‐activated protein kinase‐dependent increase in autophagy
  276. Korean Red Ginseng Tonic extends lifespan in D. melanogaster
  277. Inhibition of Isw2‐mediated chromatin remodeling by calorie restriction extends lifespan by potentiating stress response
  278. Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorh…
  279. Alaskan Lowbush Cranberry extends lifespan in C. elegans
  280. Tissue-specific downregulation of EDTP suppresses polyglutamine protein aggregates and extends lifespan in Drosophila
  281. Fully hydrogenated canola oil extends lifespan in stroke-prone spontaneously hypertensive rats
  282. Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy.
  283. Rapamycin extends murine lifespan but has limited effects on aging
  284. β‐Hydroxy‐β‐methylbutyrate extends lifespan and attenuates age‐dependent loss of flight ability in Drosophila melanogaster (246.2)
  285. Corrigendum to “Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans”[Exp. Gerontol. 48 (2013) 191–201]
  286. Geranylgeranylacetone Ameliorates Beta-Amyloid Toxicity and extends lifespan via the Heat Shock Response in Caenorhabditis elegans
  287. Reprogrammed M1 macrophages with inhibited STAT3, STAT6 and/or SMAD3 extends lifespan of mice with experimental carcinoma
  288. miR-17 extends mouse lifespan by inhibiting senescence signaling mediated by MKP7
  289. … TREATMENT REGIMENS MITIGATE THE IMPACT OF RAPAMYCIN ON GLUCOSE HOMEOSTASIS AND THE IMMUNE SYSTEM, AND extends lifespan
  290. Dietary restriction extends the lifespan of circadian mutants tim and per
  291. Moderate hypoxia (10 kPa) extends lifespan with adult but not juvenile exposure in the fruitfly, Drosophila melanogaster
  292. 629. Intravenous Delivery of a MTMR2-Encoding AAV9 Vector extends lifespan and Improves Muscle Function in Mice with X-Linked Myotubular Myopathy
  293. 713. IntraCSF Administration of AAV9/MeCP2 extends lifespan of MeCP2-Null Mice While Preventing Toxicity Associated With IV Administration
  294. Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan
  295. Neoagarotetraose extends the lifespan of Caenorhabditis elegans through AMPK mediated signaling pathways and activation of autophagy
  296. Is Gcn4-induced autophagy the ultimate downstream mechanism by which hormesis extends yeast replicative lifespan?
  297. Nmdmc overexpression extends Drosophila lifespan and reduces levels of mitochondrial reactive oxygen species
  298. Caffeine extends yeast lifespan by targeting TORC1
  299. A salicylic acid derivative extends the lifespan of Caenorhabditis elegans by activating autophagy and the mitochondrial unfolded protein response
  300. A new Schizosaccharomyces pombe chronological lifespan assay reveals that caloric restriction promotes efficient cell cycle exit and extends longevity
  301. Ferulsinaic acid attenuation of advanced glycation end products extends the lifespan of Caenorhabditis elegans
  302. Inhibition of GMP synthesis extends yeast replicative lifespan
  303. CAN1 arginine permease deficiency extends yeast replicative lifespan via translational activation of stress response genes
  304. HUMAN IGF1 extends MOZZIE lifespan
  305. Restoration of energy homeostasis by SIRT6 extends healthy lifespan
  306. Overexpression of malic enzyme in the larval stage extends Drosophila lifespan
  307. Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway
  308. rBTI extends Caenorhabditis elegans lifespan by mimicking calorie restriction
  309. Neuronal expression of a single‐subunit yeast NADH–ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan
  310. Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan
  311. Isonicotinamide extends yeast chronological lifespan through a mechanism that diminishes nucleotides
  312. Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan
  313. Aiweixin, a Traditional Uyghur Medicinal Formula, extends the lifespan of Caenorhabditis elegans
  314. SIRT1 markedly extends replicative lifespan if the NAD+ salvage pathway is enhanced
  315. Elevated Proteasome Capacity extends Replicative lifespan in Saccharomyces cerevisiae
  316. Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity
  317. Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway
  318. Curcumin Acetylsalicylate extends the lifespan of Caenorhabditis elegans
  319. gas1 mutation extends chronological lifespan via Pmk1 and Sty1 MAPKs in Schizosaccharomyces pombe
  320. SKO1 deficiency extends chronological lifespan in Saccharomyces cerevisiae
  321. Gengnianchun extends the lifespan of Caenorhabditis elegans via the insulin/IGF-1 signalling pathway
  322. The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan
  323. Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function
  324. Reduced expression of C/EBPβ-LIP extends health and lifespan in mice
  325. Post-reproductive inhibition of the autophagic vesicle nucleation complex extends C. elegans lifespan through the neurons
  326. Growth hormone receptor gene disruption in mature-adult mice improves male insulin sensitivity and extends female lifespan
  327. A novel gene, ecl1+, extends the chronological lifespan in fission yeast
  328. Telomere elongation in the gut extends zebrafish lifespan
  329. Low-dose chloroquine treatment extends the lifespan of aged rats
  330. Glucosamine extends the lifespan of Caenorhabditis elegans via autophagy induction
  331. Parishin from Gastrodia elata extends the lifespan of yeast via regulation of Sir2/Uth1/TOR signaling pathway
  332. Acidic Food pH Increases Palatability and Consumption and extends Drosophila lifespan
  333. Dairy Propionibacterium extends the mean lifespan of Caenorhabditis elegans via activation of the innate immune system
  334. D-Allose, a Stereoisomer of D-Glucose, extends the lifespan of Caenorhabditis elegans via Sirtuin and Insulin Signaling D-Allose extends Nematode lifespan via …
  335. Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway
  336. Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice
  337. Reduced expression of C/EBPb-LIP extends health and lifespan in mice
  338. Korean mistletoe (Viscum album coloratum) extract extends the lifespan of nematodes and fruit flies
  339. Mild Muscle Mitochondrial Fusion Distress extends Drosophila lifespan through an Early and Systemic Metabolome Reorganization
  340. Iron supplementation delays aging and extends cellular lifespan through potentiation of mitochondrial function
  341. Loss of tumor suppressor STAG2 promotes telomere recombination and extends the replicative lifespan of normal human cells
  342. Tectochrysin increases stress resistance and extends the lifespan of Caenorhabditis elegans via FOXO/DAF-16
  343. Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome
  344. Zymolytic Grain Extract (ZGE) Significantly extends the lifespan and Enhances the Environmental Stress Resistance of Caenorhabditis elegans
  345. A mutation that alters the 255th glutamate to lysine in RSKS-1/S6 kinase reliably extends the lifespan of C. elegans
  346. Expression of human HSP27 in yeast extends replicative lifespan and uncovers a hormetic response
  347. Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts in vitro
  348. Gentiopicroside, a secoiridoid glycoside from Gentiana rigescens Franch, extends the lifespan of yeast via inducing mitophagy and antioxidative Stress
  349. Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1 (+/−) mice
  350. Nordihydroguaiaretic Acid extends the lifespan of Drosophila and Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters …
  351. Honeysuckle extract (Lonicera pallasii L.) exerts antioxidant properties and extends the lifespan and healthspan of Drosophila melanogaster
  352. Lithocholic Acid extends Yeast Chronological lifespan, Drives the Evolution of Longevity Regulation Mechanisms in Ecosystems and Suppresses Mitochondrial …
  353. Inhibition of intestinal absorption of cholesterol by ezetimibe or bile acids by SC-435 alters lipoprotein metabolism and extends the lifespan of SR-BI/apoE double …
  354. The retrotransposon Ty1 extends chronological lifespan in Saccharomyces paradoxus by influencing cellular responses to stress

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