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200:1 Concentration

135 Science Based Ingredients Designed to Protect Your Brain 

100g = approximately 300 1/8 tsp servings 



Acacia cyanophylla flower extract

  1. Antioxidant and anti–acetylcholinesterase activities of extracts and secondary metabolites from Acacia cyanophylla
  2. Acetylcholinesterase inhibition and phyto-constituents
  3. 7 Uses for Acacia
  4. Potential biological activity of acacia honey
  5. Phytochemistry and bioactivity of Acacia sensu stricto (Fabaceae: Mimosoideae)
  6. Benefit from the association of small amounts of tannin-rich shrub foliage (Acacia cyanophylla Lindl.) with soya bean meal given as supplements to Barbarine sheep fed on oaten hay
  7. Acetylcholinesterase Inhibitory and Antioxidant Activities of Novel Symmetric Sulfamides Derived from Phenethylamines
  8. Novel ligand-based docking; molecular dynamic simulations; and absorption, distribution, metabolism, and excretion approach to analyzing potential acetylcholinesterase inhibitors for Alzheimer’s disease
  9. In vitro effects of aqueous seeds extract of Acacia cyanophylla on the opsonized zymosan-induced superoxide anions production by rat polymorphonuclear leukocytes.
  10. Chemical composition and allelopathic potential of essential oils obtained from Acacia cyanophylla Lindl. Cultivated in Tunisia.

Acori graminei Rhizoma extract

  1. Protective effects of methanol extract of Acori graminei rhizoma and Uncariae Ramulus et Uncus on ischemia-induced neuronal death and Cognitive Impairments in the rat
  2. Ameliorating effects of essential oil from Acori graminei rhizoma on learning and memory in aged rats and mice
  3. Inhibition of excitotoxic neuronal death by methanol extract of Acori graminei rhizoma in cultured rat cortical neurons
  4. Acori graminei rhizoma Ameliorated Ibotenic Acid-Induced Amnesia in Rats
  5. Effects of different fractions of Acori graminei rhizoma extracts on learning and memory abilities in Aβ-induced Alzheimer disease mice
  6. Herbal composition for the prevention and treatment of dementia
  7. Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity
  8. The Effect of Acori Graminei Rhizoma and Extract Fractions on Spatial Memory and Hippocampal Neurogenesis in Amyloid Beta 1-42 Injected Mice
  9. Effects of Acori Graminei Rhizoma on Scopolamine-induced Amnesia in Rats
  10. Neuroprotective Effect of Palmul-Chongmyeong-Tang on Ischemia-Induced Learning and Memory Deficits in the Rat

Aged garlic extract

  1. Garlic Reduces Dementia and Heart-Disease Risk
  2. The “Aged Garlic Extract” (AGE) and One of its Active Ingredients S-Allyl-LCysteine (SAC) as Potential Preventive and Therapeutic Agents for Alzheimer’s Disease (AD)
  3. Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimer’s transgenic model Tg2576
  4. Amelioration of early cognitive deficits by aged garlic extract in Alzheimer’s transgenic mice
  5. Oxidative insults to neurons and synapse are prevented by aged garlic extract and S‐allyl‐l‐cysteine treatment in the neuronal culture and APP‐Tg mouse model
  6. Ameliorating effects of aged garlic extracts against Aβ-induced neurotoxicity and cognitive impairment
  7. Aged Garlic Extract Prolongs Longevity and Improves Spatial Memory Deficit in Senescence-Accelerated Mouse
  8. Beneficial effects of aged garlic extract on learning and memory impairment in the senescence-accelerated mouse
  9. Aged garlic extract attenuates intracellular oxidative stress

Aloe arborescens Extract

  1. Aloe arborescens Extract Protects IMR-32 Cells against Alzheimer Amyloid Beta Peptide via Inhibition of Radical Peroxide Production
  2. In vitro plant regeneration, secondary metabolite production and antioxidant activity of micropropagated Aloe arborescens Mill
  3. Isolation, chemical characterization and antioxidant activities of two polysaccharides from the gel and the skin of Aloe barbadensis Miller irrigated with sea water
  4. Implications for degenerative disorders Antioxidative activity, total phenols, flavonoids, ascorbic acid, β-carotene and α-tocopherol in Aloe
  5. Neuroprotective potential of Aloe arborescens against copper induced neurobehavioral features of Parkinson’s disease in rat
  6. Aloe barbadensis: how a miraculous plant becomes reality
  7. Ameliorative effects of aqueous leaf extract of aloe arborescens on anti- hyperglycaemia and antihyperlipidemia alterations in alloxan-induced diabetic mice
  8. Stimulation of neuron‐like cell growth by Aloe substances
  9. Aloe Extract Suppresses Proliferation of Neuroblastoma Cells In Vitro
  10. Aloe arborescens juice prevents EMF-induced oxidative stress and thus protects from pathophysiology in the male reproductive system in vitro

Alpinia officinarum extract

  1. Acetylcholinesterase Inhibitory Effect of Some Medicinal Herbs Used in Iranian Traditional Medicine for Memory Improvement
  2. 7-(4-Hydroxyphenyl)-1-phenyl-4E-hepten-3-one, a Diarylheptanoid from Alpinia officinarum, Protects Neurons against Amyloid-β Induced Toxicity
  3. Evaluation of Diarylheptanoid–Terpene Adduct Enantiomers from Alpinia officinarum for Neuroprotective Activities
  4. Effects of extract of Alpinia officinarum Hance on learning memory consolidation and free radical in mice
  5. LC–MS/MS analysis, antioxidant and anticholinergic properties of galanga (Alpinia officinarum Hance) rhizomes
  6. Effects of extract of Alpinia officinarum on learning and memory deficits and the function of the central cholinergic system in mice
  7. Cholinesterases inhibition studies of biological active compounds from the rhizomes of Alpinia officinarum Hance and in silico molecular dynamics
  8. Protective effects against Amyloid-β Induced Cytotoxicity
  9. Comparison of influence of different extract of Alpinia officinanum Hance on memory acquisition, consolidation and retrieval processes in mice
  10. The Influence of Combined Application of Lentinan and Calcium Disodium Edetate on Learning,Memory Ability and the Function of the Central Cholinergic System in Lead Poisoning Mice

Alternanthera sessilis extract

  1. Nootropic potential of Alternanthera sessilis and Clerodendrum infortunatum leaves on mice
  2. Dementia in Ayurveda
  3. Screening of Aqueous and Ethanolic Extracts of Aerial Parts of Alternanthera sessilis Linn. R.br.ex.dc for Nootropic Activity
  4. Anti-Convulsant Activity of Ethanolic Extract of Ofalternanthera Sessilis on Phenytoin Induced Memory Impairment In Rats
  5. Anti-inflammatory activity of leaf extracts of Alternanthera sessilis
  6. Pharmacognostic Evaluation of Alternanthera Sessilis (L.) R.Br.ex.DC
  7. Indian herbal medicines used for treatment of dementia: an overview
  8. Evaluation of anti-stress activity of ethanolic extract of Alternanthera sessilis (Linn.) and its silver nanoparticles in chronic variable stress model
  9. In-vitro antioxident and free radical scavenging activity of Alternanthera sessilis. International J Pharmaceutical Science and Research
  10. 15 Proven Health Benefits of Alternanthera Sessilis

Amygdalin from Semen-Persicae Extract

  1. Preliminary Pharmacological Studies of the Processed Semen Persicae
  2. Bioactivity-Guided Fractionation Identifies Amygdalin as a Potent Neurotrophic Agent from Herbal Medicine Semen Persicae Extract
  3. Effect of ethanol extract from Semen Persicae on improvement of learning and memory disorder in mice
  4. Chinese herbal medicine for Alzheimer’s disease: Clinical evidence and possible mechanism of neurogenesis
  5. Bioactivity-Guided Fractionation Identifies Amygdalin as a Potent Neurotrophic Agent from Herbal Medicine Semen Persicae Extract
  6. Chinese Traditional Medicine and Adult Neurogenesis in the Hippocampus
  7. Proteomic identification of calcium-binding chaperone calreticulin as a potential mediator for the neuroprotective and neuritogenic activities of fruit-derived glycoside amygdalin
  8. Bioactivity-guided fractionation identifies amygdalin as a potent
    neurotrophic agent from herbal medicine semen persicae extract
  9. Effects of amygdalin on the functional recovery and c-Fos expression in the ventrolateral periaqueductal gray region after sciatic crushed nerve injury in rats
  10. Effect of amygdalin on cytochrome oxidases of cerebrocellular energy metabolism in cerebral ischemia

Anacyclus pyrethrum extract

  1. Memory-enhancing activity of Anacyclus pyrethrum in albino Wistar rats
  2. Root extract of Anacyclus pyrethrum ameliorates seizures, seizure-induced oxidative stress and cognitive impairment in experimental animals
  3. Effect of Anacyclus pyrethrum on Pentylenetetrazole-Induced Kindling, Spatial Memory, Oxidative Stress and Rho-Kinase II Expression in Mice
  5. Inhibitory effect of Anacycluspyrethrum extract on acetylcholinesterase enzyme by invitro methods
  6. A Review on Medicinal Plants Affecting Amnesia on Scopolamine Induced Model
  7. Medicinal herbs in Iranian traditional medicine for learning and memory
  8. In-vitro evaluation of selected Egyptian traditional herbal medicines for treatment of alzheimer disease
  9. Pharmacognostic and phytopharmacology study of Anacyclus pyrethrum : An insight
  10. Anacyclus Pyrethrum (Akarkara) Benefits, Uses

Angelica sinensis extract

  1. Phytochemical and pharmacological studies on Radix Angelica sinensis
  2. Aqueous extracts of FBD, a Chinese herb formula composed of Poria cocos, Atractylodes macrocephala, and Angelica sinensis reverse scopolamine induced memory deficit in ICR mice
  3. Radix Angelica Sinensis Extracts Ameliorate Scopolamine- and Cycloheximide-Induced Amnesia, but not p-Chloroamphetamine-Induced Amnesia in Rats
  4. Protective effects of Angelica sinensis extract on amyloid β-peptide-induced neurotoxicity
  5. Radix Angelica Sinensis that Contains the Component Z-Ligustilide Promotes Adult Neurogenesis to Mediate Recovery from Cognitive Impairment
  6. Bio-assay guided isolation and identification of anti-Alzheimer active compounds from the root of Angelica sinensis
  7. Angelica sinensis reduced Aβ-induced memory impairment in rats
  8. Effect of Ginseng and Angelica Sinensis Decoction(GASD) on Learning and Memory of Dementia Rat with Hippocampal Lesions Induced by Quinolinic Acid
  9. Pharmacological effects of Radix Angelica Sinensis (Danggui) on cerebral infarction
  10. Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress

Anthocyanins from Cranberry extract

  1. Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory
  2. Anthocyanin Metabolism in Rats and Their Distribution to Digestive Area, Kidney, and Brain
  3. Protection of the Developing Brain with Anthocyanins Against Ethanol-Induced Oxidative Stress and Neurodegeneration
  4. Effect of Vaccinium myrtillus anthocyanins on triiodothyronine transport into brain in the rat.
  5. Antioxidants and Free Radical Scavengers for the Treatment Of Stroke, traumatic brain injury and Aging
  6. A Double-Blinded, Placebo-Controlled, Randomized Trial of the Neuropsychologic Efficacy of Cranberry Juice in a Sample of Cognitively Intact Older Adults: Pilot Study Findings
  7. Effect of flavonoids on learning, memory and neurocognitive performance: relevance and potential implications for Alzheimer’s disease pathophysiology
  8. Cranberry extract supplementation exerts preventive effects through alleviating toxicity in Caenorhabditis elegans model of Alzheimer’s disease
  9. Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia
  10. Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry (Morus atropurpurea L.) on senescence-accelerated mice and prevention of Alzheimer’s disease

Apigenin From Celery Seed

  1. Neuroprotective, Anti-Amyloidogenic and Neurotrophic Effects of Apigenin in an Alzheimer’s Disease Mouse Model
  2. The Flavonoid Apigenin Protects Brain Neurovascular Coupling against Amyloid-β25-35-Induced Toxicity in Mice
  3. OP-25 – Anti-Inflammatory and Neuroprotective Effect of Apigenin: Studies in the GFAP-IL6 Mouse Model of Chronic Neuroinflammation
  4. Apigenin Ameliorates Post-Stroke Cognitive Deficits in Rats Through Histone Acetylation-Mediated Neurochemical Alterations
  5. Enhancing learning & memory through innovative dietary planning
  6. Apigenin and Quercetin: Potential Therapeutic Challenging Effective Against in Alzheimer’s Disease
  7. Apigenin and related compounds stimulate adult neurogenesis
  8. Effect of Apigenin on Learning Ability of Senile Mice Induced by D-Galactose
  9. The impact of flavonoids on memory: physiological and molecular considerations
  10. Apigenin modulates GABAergic and glutamatergic transmission in cultured cortical neurons

Arisaematis Rhizoma extract

  1. Evidence for Improved Neuropharmacological Efficacy and Decreased Neurotoxicity in Mice with Traditional Processing of Rhizoma Arisaematis
  2. Neuroprotective Herbs for Stroke Therapy In Traditional Eastern Medicine
  3. Herbal drug composition for the prevention and treatment of dementia
  4. Effects of Arisaematics rhizoma on Ischemic Damage and Cytotoxicity in Brain
  5. Screening of acetylcholinesterase inhibitors in herbal medicines
  6. Influence of combined administration of herbal complexes and warfarin on international normalized ratio in stroke and anoxic brain damage patients: A retrospective study
  7. Rhizoma arisaematis extracts and uses thereof for wound-healing effects
  8. Molecular identification of the traditional herbal medicines, Arisaematis Rhizoma and Pinelliae Tuber, and common adulterants via universal DNA barcode sequences
  9. Herbal drug composition for the prevention and treatment of dementia
  10. Anticancer activities and mechanisms of heat-clearing and detoxicating traditional Chinese herbal medicine

Artemisia capillaris extract

  1. Effects of Artemisia capillaris ethyl acetate fraction on oxidative stress and antioxidant enzyme in high-fat diet induced obese mice
  2. Anti-Alzheimer’s disease potential of coumarins from Angelica decursiva and Artemisia capillaris and structure-activity analysis
  3. Anticonvulsant Effect of Artemisia capillaris Herba in Mice
  4. Neuroprotective Effect of Ethyl Acetate Fraction of Artemisia capillaris in Mice
  5. Neuroprotective effect of the ethanol extract of Artemisia capillaris on transient forebrain ischemia in mice via nicotinic cholinergic receptor
  6. The Memory-ameliorating Effects of Artemisia in Cholinergic Dysfunction
  7. Medicinal Plants and Alzheimer’s Disease: from Ethnobotany to Phytotherapy
  8. Anti-inflammatory Potential of Artemisia capillaris and Its Constituents in LPS-induced RAW264. 7 Cells
  9. Cytoprotective effect of Artemisia capillaris fractions on oxidative stress‐induced apoptosis in V79 cells
  10. Protective effects of capillarisin on tert-butylhydroperoxide-induced oxidative damage in rat primary hepatocytes

Asparagus racemosus root extract

  1. Experimental excitotoxicity provokes oxidative damage in mice brain and attenuation by extract of Asparagus racemosus
  3. Effect of Convolvulus pluricaulis Choisy. and Asparagus racemosus Willd on learning and memory in young and old mice: A comparative evaluation
  4. Asparagus racemosus modulates the hypothalamic–pituitary–adrenal axis and brain monoaminergic systems in rats
  5. Antistress activity of ethanolic extract of Asparagus racemosus Willd roots in mice
  6. Neuroprotective Activity of Asparagus racemosus Linn. Against Ethanol-Induced Cognitive Impairment and Oxidative Stress in Rats Brain: Auspicious for Controlling the Risk of Alzheimer’s Disease
  7. Antioxidant Effects of Asparagus Racemosus Wild and Withania Somnifera Dunal in Rat Brain
  9. Asparagus recemosus enhances memory and protects against amnesia in rodent models
  10. Neuroprotective Effects of Asparagus Racemosus Linn Root Extract: An Experimental and Clinical Evidence

Aurantii nobilis Pericarpium extract

  1. [Preventive action of nobiletin, a constituent of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, against amyloid-beta peptide-induced neurotoxicity expression and memory impairment]
  2. Pharmacological action of nobiletin, a component of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, and its application for development of functional foods.
  3. The Flavonoid Baicalein Rescues Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer’s Disease
  4. Nobiletin, a Citrus Flavonoid, Improves Memory Impairment and Pathology in a Transgenic Mouse Model of Alzheimer’s Disease
  5. Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in Mice
  6. Nobiletin restoringg-impaired CREB phosphorylation rescues memory deterioration in Alzheimer’s disease model rats
  7. Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation
  8. Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action
  9. Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse
  10. Nobiletin, a Citrus Flavonoid, Reverses Learning Impairment Associated with N-Methyl-D-aspartate Receptor Antagonism by Activation of Extracellular Signal-Regulated Kinase Signaling

Avena sativa extract

  1. Antioxidant and anticholinesterase effects of frequently consumed cereal grains using in vitro test models
  2. Promotion of Cell Elongation in Avena Coleoptiles by Acetylcholine
  3. Ingested oat herb extract (Avena sativa) changes EEG spectral frequencies in healthy subjects.
  4. Acute effects of a wild green-oat (Avena sativa) extract on cognitive function in middle-aged adults: A double-blind, placebo-controlled, within-subjects trial.
  5. Benefits of Oatstraw (Avena Sativa) Extract
  6. Avena Sativa Benefits
  7. Restore Youthful Cognition and Well-Being
  8. Oat Straw Nootropic
  9. Herbal Support for Traumatic Brain Injury
  10. Oat Straw (Avena sativa) helpful in calming the nerves of those who are detoxing from drug or alcohol addiction, and can even help curb nicotine cravings.

Bacopa monnieri Extract

  1. Bacopa monnieri modulates antioxidant responses in brain and kidney of diabetic rats
  2. Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer’s disease model
  3. Bacopa monnieri Increases Cerebral Blood Flow in Rat Independent of Blood Pressure
  4. Neuroprotective effect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical culture
  5. Effects of a Standardized Bacopa monnieri Extract on Cognitive Performance, Anxiety, and Depression in the Elderly: A Randomized, Double-Blind, Placebo-Controlled Trial
  6. Bacopa monnieri modulates endogenous cytoplasmic and mitochondrial oxidative markers in prepubertal mice brain
  7. Neuroprotective Role of Bacopa monnieri Extract in Epilepsy and Effect of Glucose Supplementation During Hypoxia: Glutamate Receptor Gene Expression
  8. Bacopa monnieri Extract Offsets Rotenone-Induced Cytotoxicity in Dopaminergic Cells and Oxidative Impairments in Mice Brain
  9. Does Bacopa monnieri Improve Memory Performance in Older Persons? Results of a Randomized, Placebo-Controlled, Double-Blind Trial
  10. Neuroprotective Potential of Bacopa monnieri and Bacoside A Against Dopamine Receptor Dysfunction in the Cerebral Cortex of Neonatal Hypoglycaemic Rats


  1. Baicalein loaded in tocol nanostructured lipid carriers (tocol NLCs) for enhanced stability and brain targeting
  2. Post‐injury baicalein improves histological and functional outcomes and reduces inflammatory cytokines after experimental traumatic brain injury
  3. brain injury involves PTEN/AKT pathway
  4. Flavonoid Baicalein Attenuates Activation-Induced Cell Death of Brain Microglia
  5. Baicalein protects rat brain mitochondria against chronic cerebral hypoperfusion-induced oxidative damage
  6. Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice
  7. Protective effects of baicalein against rotenone-induced neurotoxicity in PC12 cells and isolated rat brain mitochondria
  8. The flavonoid baicalein promotes NMDA receptor‐dependent long‐term potentiation and enhances memory
  9. Mismatch between changes in baicalein-induced memory-related biochemical parameters and behavioral consequences in mouse
  10. Baicalein improves cognitive deficits induced by chronic cerebral hypoperfusion in rats

Benincasa hispida fruit extract

  1. Alzheimer’s disease
  2. Evaluation of the memory and learning improving effects of Benincasa bispida seeds in mice
  4. Effect of methanolic extract of Benincasa hispida against histamine and acetylcholine induced bronchospasm in guinea pigs
  5. The Pharmacological Importance of Benincasa hispida. A review
  6. Antidepressant-like activity of Benincasa hispida fruits in mice: Possible involvement of monoaminergic and GABAergic systems
  7. The Pharmacological Importance of Benincasa hispida. A review
  8. Effect of dried fruit extract of benincasa hispida on Brain behabiour in laboratory animals.
  9. Dose Dependent Activity of Benincasa hispida on Colchicine Induced Experimental Rat Model of Alzheimer`s Disease
  10. Evaluation of the Memory and Learning Improving Effects of Benincasa hispida Seeds in Mice

Betula platyphylla bark extract

  1. Cognition-enhancing and neuroprotective activities of the standardized extract of Betula platyphylla bark and its major diarylheptanoids
  2. The effects of Betula platyphylla bark on amyloid beta-induced learning and memory impairment in mice
  3. Neuroprotective Effects of the Standardized Extract of Betula Platyphylla Bark against Amyloid Beta Induced Toxicity in Amnesic Mice
  4. Acetylcholinesterase inhibition and phyto-constituents
  5. Ameliorative effect of betulin from Betula platyphylla bark on scopolamine-induced amnesic mice
  6. New Four-herb Formula Ameliorates Memory Impairments via Neuroprotective Effects on Hippocampal Cells
  7. The effects of betulinic acid on neurobehavioral activity, electrophysiology and histological changes in an animal model of the Alzheimer’s disease
  8. Betulinic acid protects against cerebral ischemia–reperfusion injury in mice by reducing oxidative and nitrosative stress
  9. Betulinic acid ameliorates endothelium-dependent relaxation in l-NAME-induced hypertensive rats by reducing oxidative stress
  10. In vivo protective effect of betulinic acid on dexamethasone induced thymocyte apoptosis by reducing oxidative stress

Black grape skin extract

  1. Red wine micronutrients as protective agents in Alzheimer-like induced insult
  2. Neuroprotective properties of resveratrol in different neurodegenerative disorders
  4. Benefits of Grape Chemicals on Human Health
  5. Black grape extract supplementation attenuates blood oxidative stress in response to acute exercise
  6. The effects of an antioxidant-supplemented beverage on exercise-induced oxidative stress: results from a placebo-controlled double-blind study in cyclists
  7. Protective potential of Black grapes against lead induced oxidative stress in rats
  8. Phenolic Compounds and Antioxidant Activity of White, Red, Black Grape Skin and White Grape Seeds
  9. Medications and Diet Protective Factors for AD
  10. Neuro‐Protective Effects of Resveratrol on Carbon Monoxide‐Induced Toxicity in Male Rats

Blackcurrant Anthocyanins extract

  1. Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer’s disease
  2. Cytoprotective effects of anthocyanins and other phenolic fractions of Boysenberry and blackcurrant on dopamine and amyloid β‐induced oxidative stress in transfected COS‐7 cells
  3. Supplementation of Blackcurrant Anthocyanins Increased Cyclic Glycine-Proline in the Cerebrospinal Fluid of Parkinson Patients: Potential Treatment to Improve Insulin-Like Growth Factor-1 Function
  4. The impact of blackcurrant juice on attention, mood and brain wave spectral activity in young healthy volunteers
  5. Boysenberry and blackcurrant drinks increased the plasma antioxidant capacity in an elderly population but had little effect on other markers of oxidative stress
  6. Acute supplementation with blackcurrant extracts modulates cognitive functioning and inhibits monoamine oxidase-B in healthy young adults
  7. Mitigation of the impact of cognitive fatigue on simple motor performance by phytochemicals: the effect of a blackcurrant supplement
  8. Dietary benefits from blackcurrant pomace components
  9. The Psychopharmacological Effects of Blackcurrant Phytochemicals in Humans
  10. Blackcurrant Anthocyanins can Aid in the Prevention and Treatment of Visual Diseases

Boschniakia rossica extract

  1. [Effect of Boschniakia rossica extract on free radicals in brain of D-galactose induced senile rats]
  3. Influence of Boschniakia rossica extract on the content of Ach and the capability of learning and memory in Alzheimer’s disease rats
  4. The Impact of Boschniakia Rossica Extract on the Ach ChAT and AchE of AD Rats
  5. Effect of boschniakia rossica extract on the microglia cells in the frontal lobe and learning and memory ability of AD rats
  6. The Influence of Boschniakia rossica Extract on Learning and Memory Capability and Neuronal Apoptosis in AD Model Rats
  7. Reinforcement effects of Boschniakia rossica on discrimination learning in cholinergic lesions of rats
  8. [Intervention effect of aqueous fractions from Boschniakia rossica on hepatic oxidative stress in mice with liver injury induced by carbon tetrachloride]
  9. Boschniakia rossica prevents the carbon tetrachloride-induced hepatotoxicity in rat
  10. The treatment of Alzheimer’s disease using Chinese Medicinal Plants: From disease models to potential clinical applications

Caesalpinia crista Linn seed extract

  1. Anti-amyloidogenic property of leaf aqueous extract of Caesalpinia crista
  2. Learning and memory enhancing activity of ethanolic extract of dried seed kernels of Caesalpinia crista Lin. In albino mice
  3. Anti epileptic activity of some medicinal plants
  4. Multiple pharmacological activities of Caesalpinia crista against aluminium-induced neurodegeneration in rats: Relevance for Alzheimer’s disease
  5. Phytochemical composition of Caesalpinia crista extract as potential source for inhibiting cholinesterase and β-amyloid aggregation: Significance to Alzheimer’s disease
  6. Traditional uses, medicinal and phyto-pharmacological properties of Caesalpinia crista Linn–An overview
  7. Comparative study on anti-oxidant and anti-inflammatory activities of Caesalpinia crista and Centella asiatica leaf extracts
  8. Caesalpinia Crista Linn. Induces Protection against DNA and Membrane Damage
  9. Assessment of the Antioxidant and Reactive Oxygen Species Scavenging Activity of Methanolic Extract of Caesalpinia crista Leaf
  10. Hydroalcoholic extracts of Indian medicinal plants can help in amelioration from oxidative stress through antioxidant properties

Cape Jasmine extract

  1. Effect of the Crude Extract of Cape jasmine on Behavior and the Hippocampal Neurogenesis in Mouse Model of Depression
  2. Evaluation of Sedative Effects of Geniposide and Gardenia Yellow Extracted from Cape Jasmine Fruit on Mice
  3. Effects of Crude Extract of Cape Jasmine on Learning and Memory Function in Experimental Dementia Animal Model
  4. Crocetin, a Carotenoid from Gardenia jasminoides Ellis, Protects against Hypertension and Cerebral Thrombogenesis in Stroke‐prone Spontaneously Hypertensive Rats
  5. Learning and memory improvement and neuroprotection of Gardenia jasminoides (Fructus gardenia) extract on ischemic brain injury rats
  6. Rapid Antidepressant Activity of Ethanol Extract of Gardenia jasminoides Ellis Is Associated with Upregulation of BDNF Expression in the Hippocampus
  7. Chemistry and bioactivity of Gardenia jasminoides
  8. Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3
  9. Neuroprotective effects of geniposide on Alzheimer’s disease pathology
  10. Multi-faced neuroprotective effects of geniposide depending on the RAGE-mediated signaling in an Alzheimer mouse model

Carnosic acid

  1. Carnosic acid, a catechol‐type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S‐alkylation of targeted cysteines on Keap1
  2. Nrf2–ARE activator carnosic acid decreases mitochondrial dysfunction, oxidative damage and neuronal cytoskeletal degradation following traumatic brain injury in mice
  3. Protection from cyanide‐induced brain injury by the Nrf2 transcriptional activator carnosic acid
  4. Neuroprotective Effects of Carnosic Acid in an Experimental Model of Alzheimer’s Disease in Rats
  5. Upregulation of Endogenous Neurotrophin Levels in the Brain by Intranasal Administration of Carnosic Acid
  6. Effect of botanical extracts containing carnosic acid or rosmarinic acid on learning and memory in SAMP8 mice
  7. Protective Effect of Carnosic Acid, a Pro-Electrophilic Compound, in Models of Oxidative Stress and Light-Induced Retinal Degeneration
  8. Carnosic acid protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson’s disease: Involvement of antioxidative enzymes induction
  9. Neuroprotective effects of carnosic acid on neuronal cells under ischemic and hypoxic stress
  10. The Dietary Components Carnosic Acid and Carnosol as Neuroprotective Agents: a Mechanistic View


  1. Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain
  2. Toxic effects of β-amyloid(25–35) on immortalised rat brain endothelial cell: protection by carnosine, homocarnosine and β-alanine
  3. Protective effects of carnosine against malondialdehyde-induced toxicity towards cultured rat brain endothelial cells
  4. Carnosine Protects the Brain of Rats and Mongolian Gerbils against Ischemic Injury: After-Stroke-Effect
  5. Effect of Anserine/Carnosine Supplementation on Verbal Episodic Memory in Elderly People
  6. Carnosine attenuates oxidative stress and apoptosis in transient cerebral ischemia in rats
  7. Daily Carnosine and Anserine Supplementation Alters Verbal Episodic Memory and Resting State Network Connectivity in Healthy Elderly Adults
  8. Carnosine pretreatment protects against hypoxia–ischemia brain damage in the neonatal rat model
  9. Protective Effect of Carnosine on Subcortical Ischemic Vascular Dementia in Mice
  10. Carnosine and its (S)-Trolox™ derivative protect animals against oxidative stress

Carum carvi Linn caraway fruit extract

  1. Adaptogenic and Nootropic Activities of Aqueous Extracts of Carum Carvi Linn (Caraway) Fruit: An Experimental Study in Wistar Rats
  2. Anticonvulsant Effect of the Aqueous Extract and Essential Oil of Carum Carvi L. Seeds in a Pentylenetetrazol Model of Seizure in Mice
  3. Carum carvi Linn (Umbelliferae) Attenuates Lipopolysaccharide-Induced Neuroinflammatory Responses via Regulation of NF-κB Signaling in BV-2 Microglia
  4. Cuminum cyminum and Carum carvi: An update
  5. Phytochemical and pharmacological properties of carum carvi
  6. Bioavailability enhancing activity of carum carvi extracts and fractions thereof
  7. Adaptogenic and nootropic activities of aqueous
  8. Importance of Cuminum cyminum L. and Carum carvi L. in traditional medicaments – a review
  9. Carum Carvi- An Updated Review
  10. A critical drug review of ingredients of Sarasvatha choorna: used as a remedy for dementia

Celastrus paniculatus seed extract

  1. Reversal of Scopolamine-Induced Deficits in Navigational Memory Performance by the Seed Oil of Celastrus paniculatus
  2. Nootropic activity of Celastrus paniculatus seed
  3. Celastrus paniculatus seed oil and organic extracts attenuate hydrogen peroxide- and glutamate-induced injury in embryonic rat forebrain neuronal cells
  4. Celastrus paniculatus seed water soluble extracts protect against glutamate toxicity in neuronal cultures from rat forebrain
  5. Celastrus paniculatus seed water soluble extracts protect cultured rat forebrain neuronal cells from hydrogen peroxide-induced oxidative injury
  6. Oxidative stress in brains of male rats intoxicated with aluminium and neuromodulating effect of Celastrus paniculatus alcoholic seed extract
  7. Effect of Celastrus paniculatus seed extract on the brain of albino rats
  8. Effect of Celastrus paniculatus seed oil (Jyothismati oil) on acute and chronic immobilization stress induced in swiss albino mice
  9. Cortico-hippocampal salvage in chronic aluminium induced neurodegeneration by Celastrus paniculatus seed oil: Neurobehavioural, biochemical, histological study
  10. Anti-Alzheimer and Antioxidant Activity of Celastrus paniculatus Seed

Centella asiatica extract

  1. Asiatic acid, a pentacyclic triterpene from Centella asiatica, is neuroprotective in a mouse model of focal cerebral ischemia
  2. Effect of different extracts of Centella asiatica on cognition and markers of oxidative stress in rats
  3. Effect of Centella asiatica on cognition and oxidative stress in an intracerebroventricular streptozotocin model of Alzheimer’s disease in rats
  4. Effect of Centella asiatica on pentylenetetrazole-induced kindling, cognition and oxidative stress in rats
  5. Effect of Centella asiatica fresh leaf aqueous extract on learning and memory and biogenic amine turnover in albino rats
  6. [Effects of total triterpenes of Centella asiatica on the corticosterone levels in serum and contents of monoamine in depression rat brain]
  7. Centella asiatica extract selectively decreases amyloid β levels in hippocampus of Alzheimer’s disease animal model
  8. Exploring the Role of “Brahmi” (Bacopa monnieri and Centella asiatica) in Brain Function and Therapy
  9. Centella asiatica treatment during postnatal period enhances learning and memory in mice
  10. Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential


  1. Effect of Chlorella and Its Fractions on Blood Pressure, Cerebral Stroke Lesions, and Life-Span in Stroke-Prone Spontaneously Hypertensive Rats
  2. Preventive effects of Chlorella on cognitive decline in age-dependent dementia model mice
  3. Protective Effect of Chlorella vulgaris against Lead-Induced Oxidative Stress in Rat Brains
  4. Chlorella vulgaris reduces the impact of stress on hypothalamic–pituitary–adrenal axis and brain c-fos expression
  5. Chlorella sorokiniana Extract Improves Short-Term Memory in Rats
  6. A randomized controlled trial of 6-week Chlorella vulgaris supplementation in patients with major depressive disorder
  7. Therapeutic potentials of unicellular green alga Chlorella in advanced glycation end product (AGE)-related disorders
  8. Effect of Docosahexaenoic Acid-Fortified Chlorella vulgaris Strain CK22 on the Radial Maze Performance in Aged Mice
  9. Potential Modulator Role of Chlorella vulgaris and Spirulina platensis On Monosodium Glutamate Oxidative Stress
  10. Oxidative stress and antioxidant content in Chlorella vulgaris after exposure to ultraviolet‐B radiation

Chlorogenic acid (CGA) green coffee bean extract

  1. Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice
  2. Chlorogenic acid ameliorates brain damage and edema by inhibiting matrix metalloproteinase-2 and 9 in a rat model of focal cerebral ischemia
  3. Comparative Study on the Inhibitory Effect of Caffeic and Chlorogenic Acids on Key Enzymes Linked to Alzheimer’s Disease and Some Pro-oxidant Induced Oxidative Stress in Rats’ Brain-In Vitro
  4. Chlorogenic Acid and Its Metabolite m-Coumaric Acid Evoke Neurite Outgrowth in Hippocampal Neuronal Cells
  5. Chlorogenic acid, a polyphenol in coffee, protects neurons against glutamate neurotoxicity
  6. Roasted Coffees High in Lipophilic Antioxidants and Chlorogenic Acid Lactones Are More Neuroprotective
  7. Cognitive and neuroprotective effects of chlorogenic acid
  8. A Randomised Placebo-Controlled Trial to Differentiate the Acute Cognitive and Mood Effects of Chlorogenic Acid from Decaffeinated Coffee
  9. Does coffee enriched with chlorogenic acids improve mood and cognition after acute administration in healthy elderly? A pilot study
  10. Current evidence for the use of coffee and caffeine to prevent age-related cognitive decline and Alzheimer’s disease

Chrysin and Tectochrysin from Alpinia oxyphylla Fruit

  1. Chrysin improves cognitive deficits and brain damage induced by chronic cerebral hypoperfusion in rats
  2. Flavonoid Chrysin prevents age-related cognitive decline via attenuation of oxidative stress and modulation of BDNF levels in aged mouse brain
  3. Chrysin treatment improves diabetes and its complications in liver, brain, and pancreas in streptozotocin-induced diabetic rats
  4. Chrysin Protects against Focal Cerebral Ischemia/Reperfusion Injury in Mice through Attenuation of Oxidative Stress and Inflammation
  5. Protective role of chrysin against oxidative stress in d‐galactose‐induced aging in an experimental rat model
  6. Neuroprotective effects of chrysin: From chemistry to medicine
  7. Neuroprotective role of chrysin in attenuating loss of dopaminergic neurons and improving motor, learning and memory functions in rats
  9. Mitigating effect of chrysin loaded solid lipid nanoparticles against Amyloid β25–35 induced oxidative stress in rat hippocampal region: An efficient formulation approach for Alzheimer’s disease
  10. Chrysin, a Natural FlavonoidAttenuates Cognitive Dysfunction and Neuronal Loss Associated withA myloid β (25-35)-Induced Oxidative Stress: An Experimental Model of Alzheimer’s Disease

Cinnamomum Zeylanicum extract

  1. Effect of Cinnamomum zeylanicum extract on scopolamine-induced cognitive impairment and oxidative stress in rats
  2. Attenuating effect of standardized lyophilized Cinnamomum zeylanicum bark extract against streptozotocin-induced experimental dementia of Alzheimer’s type
  3. Cognition enhancing effect of the aqueous extract of Cinnamomum zeylanicum on non-transgenic Alzheimer’s disease rat model: Biochemical, histological, and behavioural studies
  4. Anticholinesterase activity of Cinnamomum zeylanicum L. leaf extract
  5. The effect of Cinnamomum zeylanicum bark water extract on memory performance in alloxan-induced diabetic mice
  6. Effect of traditional plant medicines (Cinnamomum zeylanicum and Syzygium cumini) on oxidative stress and insulin resistance in streptozotocin-induced diabetic rats
  7. Pharmacological screening of herbal extract of piper nigrum (Maricha) and Cinnamomum zeylanicum (Dalchini) for anticonvulsant activity
  8. Screening of traditional Indian spices for inhibitory activity of Acetylcholinesterase and Butyrylcholinesterase enzymes
  9. Screening the methanol extracts of some Iranian plants for acetylcholinesterase inhibitory activity
  10. Antiamylase, Anticholinesterases, Antiglycation, and Glycation Reversing Potential of Bark and Leaf of Ceylon Cinnamon (Cinnamomum zeylanicum Blume) In Vitro

Citrullus colocynthis (L.)

  1. Effect of Citrullus colocynthis in ameliorate the oxidative stress and nephropathy in diabetic experimental rats
  2. Watermelon (Citrullus lanatus (Thunb.) Matsum. and Nakai) Juice Modulates Oxidative Damage Induced by Low Dose X-Ray in Mice
  4. Citrullus colocynthis fruit extract as an anti-depressant in mice
  7. Antioxidant and radical scavenging effect of Citrullus colocynthis
  9. Anti Alzheimer’s Disease Related Activities of Israeli Medicinal Plants

Citrus reticulata peel extract

  1. Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action
  2. Nobiletin‐rich Citrus reticulata peels, a kampo medicine for Alzheimer’s disease: A case series
  3. Neuroprotective Effects of Citrus reticulata in Scopolamine-Induced Dementia Oxidative Stress in Rats
  4. Anti-dementia Activity of Nobiletin, a Citrus Flavonoid: A Review of Animal Studies
  5. Fermented Citrus reticulata (ponkan) fruit squeezed draff that contains a large amount of 4′-demethylnobiletin prevents MK801-induced memory impairment
  6. Nobiletin-rich Citrus reticulata peels for Alzheimer’s disease
  7. Effects of Nobiletin in Animal Models of Cognitive Impairment
  8. Anticholinesterase and antioxidative properties of water-extractable phytochemicals from some citrus peels
  9. Neuroprotective Effects of Citrus Fruit-Derived Flavonoids, Nobiletin and Tangeretin in Alzheimer’s and Parkinson’s Disease
  10. Effects of Nobiletin in Animal Models of Cognitive Impairment

Clerodendron phlomidis Linn.(Verbenaceae)

  1. Antiamnesic evaluation of C. phlomidis Linn. bark extract in mice
  2. P03-81 – Cognition improving effects of clerodendron phlomidis linn. bark extract in mice
  3. Comprehensive review of Clerodendrum phlomidis: a traditionally used bitter
  4. Effect of pectolinaringenin, a flavonoid from Clerodendrum phlomidis, on total protein, glutathione S-transferase and esterase activities of Earias vittella and Helicoverpa armigera
  5. Protection by Clerodendrum phlomidis against manganese toxicity
  7. Pre–clinical evolutionary study of Clerodendrum phlomidis as an anti–obesity agent against high fat diet induced C57BL/6J mice
  8. Clerodendrum phlomidis linn.f – International Journal Of Ayurvedic
  9. Sub-Chronic Toxicity study of Aqueous extract of Clerodendrum Phlomidis Leaves
  10. Central Nervous System activities of Clerodendrum multiflorum stems

Coeloglossum viride var. bracteatum extract

  1. Coeloglossum viride var. bracteatum extract attenuates d-galactose and NaNO2 induced memory impairment in mice
  2. Effects of Coeloglossum. viride var. bracteatum Extract on Memory Deficits and Pathological Changes in Senescent Mice
  3. Protective effects of extract of Coeloglossum viride var. bracteatum on ischemia-induced neuronal death and cognitive impairment in rats
  4. Effect and mechanism of Coeloglossum viride var. bracteatum extract on scopolamine-induced deficits of learning and memory behavior of rodents
  5. [Effect of Coeloglossum. viride var. bracteatum extract on oxidation injury in sub-acute senescent model mice]
  6. Potential Protection of Coeloglossum viride var. Bracteatum Extract against Oxidative Stress in Rat Cortical Neurons
  7. Protective Effect of Coeloglossum viride var. bracteatum Extract against Injury Induced by Amyloid Peptide in Rat Prefrontal Cortex Neurons
  8. Effect of the extract from Coeloglossum viride(L.) Hartm.Var.bracteatum(Willd.) Richter on learning and memory in dementia rats
  9. Neuroprotective effects of a Coeloglossum viride var. Bracteatum extract in vitro and in vivo
  10. Improvement of Coeloglossum viride var.bracteatum extract in IBO-induced AD rats

Colchicum speciosum Steven (Colchicaceae) corms

  1. An Overview on Potential Neuroprotective Compounds for Management of Alzheimer’s Disease
  2. acetylcholinesterase inhibitory alkaloids for the treatment of Alzheimer’s disease
  3. Natural products as a source of Alzheimer’s drug leads
  4. Acetylcholinesterase Inhibitors of Natural Origin
  5. Natural Products and their Derivatives as Cholinesterase Inhibitors in the Treatment of Neurodegenerative Disorders: An Update
  6. Antioxidant and free radical scavenging activity of H. officinalis L. var. angustifolius, V. odorata, B. hyrcana and C. speciosum
  7. Cholinergic activity of isoquinoline alkaloids from the showy autumn crocus (Colchicum speciosum Stev.)
  8. Anticholinesterase Efficiency of Some Tropolone Alkaloids and Their Lumiderivatives
  9. Antioxidant and free radical scavenging activity of H. officinalis L. var. angustifolius, V. odorata, B. hyrcana and C. speciosum
  10. Evaluation of Bioactive Compounds as Acetylcholinesterase Inhibitors from Medicinal Plants

Coptidis Rhizoma

  1. Anti-Alzheimer and Antioxidant Activities of Coptidis Rhizoma Alkaloids
  2. Kinetic difference of berberine between hippocampus and plasma in rat after intravenous administration of Coptidis rhizoma extract
  3. The uptake and transport behavior of berberine in Coptidis Rhizoma extract through rat primary cultured cortical neurons
  4. Coptidis Rhizoma: protective effects against peroxynitrite‐induced oxidative damage and elucidation of its active components
  5. Potentiation of Nerve Growth Factor-Induced Neurite Outgrowth in PC12 Cells by a Coptidis Rhizoma Extract and Protoberberine Alkaloids
  6. Characterization of the transportation of berberine in Coptidis rhizoma extract through rat primary cultured cortical neurons
  7. Computational pharmaceutical analysis of anti-Alzheimer‘s Chinese medicine Coptidis Rhizoma alkaloids
  8. Virtual screening studies of Chinese medicine Coptidis Rhizoma as alpha7 nicotinic acetylcholine receptor agonists for treatment of Alzheimer’s disease
  9. Coptidis Rhizoma Prevents Heat Stress-Induced Brain Damage and Cognitive Impairment in Mice
  10. Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease

Coptis (Ranunculaceae)

  1. Berberine and total base from rhizoma coptis chinensis attenuate brain injury in an aluminum-induced rat model of neurodegenerative disease.
  2. Monoamine Oxidase Inhibitors from Rhizoma of Coptis
  3. Study on the protective effects of coptis total alkaloids on the brain damage induced by aluminium overload
  4. [The effect of Coptis chinensis on lipid peroxidation and antioxidases activity in rats]
  5. Protective effects and mechanism of total coptis alkaloids on A β25–35 induced learning and memory dysfunction in rats
  6. Protective Effects of Total Base of Coptis Against Brain Injury Induced by Aluminum Overload in Rats
  7. The Improving Effect of Decoction Decoction of Coptis and Its Extract on intelligence
  8. Chinese Herbs for Memory Disorders: A Review and Systematic Analysis of Classical Herbal Literature
  9. The total alkaloids from Coptis chinensis Franch improve cognitive deficits in type 2 diabetic rats
  10. Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function


  1. Cordycepin attenuates traumatic brain injury-induced impairments of blood-brain barrier integrity in rats
  2. Cordycepin protects against cerebral ischemia/reperfusion injury in vivo and in vitro
  3. The Molecular Mode of Brain Mrna Processing Damage Followed by the Suppression of Post-Transcriptional Poly(A) Synthesis with Cordycepin
  4. The Effect of Cordycepin on Nuclear RNA Synthesis in Nerve and Glial Cells
  5. A Phytochemically Characterized Extract of Cordyceps militaris and Cordycepin Protect Hippocampal Neurons from Ischemic Injury in Gerbils
  6. Effects of cordycepin on Y-maze learning task in mice
  7. Antidepressant-Like Effects of Cordycepin in a Mice Model of Chronic Unpredictable Mild Stress
  8. Cordycepin Suppresses Excitatory Synaptic Transmission in Rat Hippocampal Slices Via a Presynaptic Mechanism
  9. Cordycepin induces apoptotic cell death of human brain cancer through the modulation of autophagy
  10. Cordycepin decreases activity of hippocampal CA1 pyramidal neuron through membrane hyperpolarization

Cordyceps ophioglossoides extract

  1. Mycelial Extract of Cordyceps ophioglossoides Prevents Neuronal Cell Death and Ameliorates β-Amyloid Peptide-Induced Memory Deficits in Rats
  2. Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin
  3. Chapter 5 Cordyceps as an Herbal Drug
  4. Cordyceps ophioglossoides (Ehrh.)
  5. Tolypocladium ophioglossoides, The Golden Thread Cordyceps
  6. the structure and development of the fungi
  7. Optimization for Production of Intracellular Polysaccharide from Cordyceps ophioglossoides L2 in Submerged Culture and Its Antioxidant Activities in vitro
  8. Co-N reaction – a new serological activity index – on Wegener’s granulomatosis
  9. Optimized Extraction and Antioxidant Activities of Polysaccharides from Two Entomogenous Fungi
  10. Cordyceps for Anti-Aging & Exercise Performance

Cornus mas L. seed

  1. The Neuroprotective Effect of Cornus mas on Brain Tissue of Wistar Rats
  2. The Effect of CornelianCherry (Cornus mas L.) Extract on Serum Ghrelin and Corticosterone Levels inRat Model
  3. Protective Effect of Cornus mas Fruits Extract on Serum Biomarkers in CCl4-Induced Hepatotoxicity in Male Rats
  4. Postharvest salicylic acid treatment enhances antioxidant potential of cornelian cherry fruit
  5. Neuroprotective effect of cyanidin-3-O-glucoside anthocyanin in mice with focal cerebral ischemia
  6. Facts and Benefits of Cornelian Cherry
  7. Fruits And Health: Cornelian Cherry Health Benefits
  8. Antioxidant capacity of cornelian cherry (Cornus mas L.) – comparison between permanganate reducing antioxidant capacity and other antioxidant methods.
  9. A comparative study on the in vitro antioxidant potentials of three edible fruits: cornelian cherry, Japanese persimmon and cherry laurel.
  10. Current Alzheimers management with berries fruits therapy

Corydalis (Papaveraceae)

  1. Regulation of glutamate level in rat brain through activation of glutamate dehydrogenase by Corydalis
  2. Simultaneous determination of four alkaloids in mice plasma and brain by LC–MS/MS for pharmacokinetic studies after administration of Corydalis Rhizoma and Yuanhu Zhitong extracts
  4. Human Brain GABA-T (γ-aminobutyric acid transaminase) Inhibitory Alkaloids from Corydalis
  5. Anti-amnestic Activity of Pseudocoptisine from Corydalis Tuber
  6. Effects of total alkaloids from Rhizoma Corydalis decumbeutis (TARCD) on content of brain 5–HT and DA of Alzheimer^s Disease rats
  7. [Effects of Corydalis ambailis migo total alkaloids on experimental cerebral ischemia]
  8. Effects of Rhizoma Corydalis Decumbentis on learning and memory ability and brain acetylcholinesterase activity in mice
  9. Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii
  10. Effect of Rhizoma Corydalis on focal cerebral infarct in ischemia-reperfusion injured rats

Crocus sativus

  1. Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus
  2. Effects of Saffron (Crocus sativus L.) and its Active Constituent, Crocin, on Recognition and Spatial Memory after Chronic Cerebral Hypoperfusion in Rats
  3. Effect of Saffron (Crocus sativus) on Neurobehavioral and Neurochemical Changes in Cerebral Ischemia in Rats
  4. Protective Effects of Crocus Sativus L. Extract and Crocin against Chronic-Stress Induced Oxidative Damage of Brain, Liver and Kidneys in Rats
  5. Crocus sativus L. extracts antagonize memory impairments in different behavioural tasks in the rat
  6. A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s disease
  7. Protective Effect of Safranal, a Constituent of Crocus sativus, on Quinolinic Acid-induced Oxidative Damage in Rat Hippocampus
  8. Effects of Active Constituents of Crocus sativus L., Crocin on Streptozocin-Induced Model of Sporadic Alzheimer’s Disease in Male Rats
  9. Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment
  10. Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial

Curcuma longa L.(Zingiberaceae)

  1. Neuroprotective role of curcumin from Curcuma longa on ethanol‐induced brain damage
  2. Protective effect of Curcumin, the active principle of turmeric (Curcuma longa) in haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes in rat brain
  3. Antidepressant activity of aqueous extracts of Curcuma longa in mice
  4. Effects of Curcumin (Curcuma longa) on Learning and Spatial Memory as Well as Cell Proliferation and Neuroblast Differentiation in Adult and Aged Mice by Upregulating Brain-Derived Neurotrophic Factor and CREB Signaling
  5. The influence of the long-term administration of Curcuma longa extract on learning and spatial memory as well as the concentration of brain neurotransmitters and level of plasma corticosterone in aged rats
  6. Curcuma Oil: Reduces Early Accumulation of Oxidative Product and is Anti-apoptogenic in Transient Focal Ischemia in Rat Brain
  7. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats
  8. Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats
  9. Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models
  10. Protective effect of curcumin (Curcuma longa), against aluminium toxicity: Possible behavioral and biochemical alterations in rats


  1. Curcumin Suppresses Janus Kinase-STAT Inflammatory Signaling through Activation of Src Homology 2 Domain-Containing Tyrosine Phosphatase 2 in Brain Microglia
  2. Curcumin and its nano-formulation: The kinetics of tissue distribution and blood–brain barrier penetration
  3. Through metal binding, curcumin protects against lead- and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain
  4. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition
  5. Curcumin blocks brain tumor formation
  6. Neuroprotective and Anti-ageing Effects of Curcumin in Aged Rat Brain Regions
  7. Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood–brain barrier damage
  8. A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors
  9. Anti-ischemic Effect of Curcumin in Rat Brain
  10. Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury

Cycas circinalis seed extract

  1. Sago Nutrition
  2. What Are the Health Benefits of Sago?
  3. 9 Surprising Health Benefits of Sago
  4. Health benefits of eating sago / saboodana


  1. Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management
  2. Cycloastragenol: An exciting novel candidate for age‑associated diseases (Review)
  3. The Treatment of Brain Inflammation in Alzheimer’s Disease. Can Traditional Medicines Help?
  4. Medicinal Plant for Curing Alzheimer’s Disease
  5. Chapter 73 – Herbs and Dementia: A Focus on Chinese and Other Traditional Herbs
  7. Research Supports Anti-Aging Benefits of “Elite Class” of Tonic Herbs
  8. Anti-Aging and Anti-Viral Effects of “Herbal Youth” Compound
  9. Cycloastragenol Benefits

Danshensu from the aqueous extract of Salvia miltiorrhiza

  1. The Role of P-Glycoprotein in Transport of Danshensu across the Blood-Brain Barrier
  2. Down-regulation of P-glycoprotein expression contributes to an increase in Danshensu accumulation in the cerebral ischemia/reperfusion brain
  3. Neuroprotective effect of Danshensu derivatives as anti-ischaemia agents on SH-SY5Y cells and rat brain
  4. Neuroprotective effect and underlying mechanism of sodium danshensu [3-(3,4-dihydroxyphenyl) lactic acid from Radix and Rhizoma Salviae miltiorrhizae = Danshen] against cerebral ischemia and reperfusion injury in rats
  5. Characterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid B
  6. Effect of Danshensu on the iNOS、NOS and NO level in neonatal rats with hypoxic-ischemic brain injury
  7. Anxiolytic-like effect of danshensu [(3-(3,4-dihydroxyphenyl)-lactic acid)] in mice
  8. Danshensu ameliorates the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation
  9. [Protective effect of novel edaravone and danshensu conjugate on focal cerebral ischemia-reperfusion injury 
in rats and its underlying mechanism]
  10. [Pharmacokinetics study on Danshensu in rats by brain microdialysis and automated blood technique]

Daucus carota seed extract

  1. Anti-dementia potential of Daucus carota seed extract in rats
  2. Antinociceptive and Anti-Inflammatory Properties of Daucus carota Seeds Extract
  3. Nutritional and therapeutic importance of Daucus carota-A
  4. Pharmacological Evidence for the Potential of Daucus carota in the Management of Cognitive Dysfunctions
  5. Calcium and phospholipid activation of a recombinant calcium-dependent protein kinase (DcCPK1) from carrot (Daucus carota L.)
  6. In vivo antioxidant and hepatoprotective activity of methanolic extracts of Daucus carota seeds in experimental animals
  7. Structural responses of Daucus carota root-organ cultures and the arbuscular mycorrhizal fungus, Glomus intraradices, to 12 pharmaceuticals
  8. Flavonols, Flavones, Flavanones, and Human Health: Epidemiological Evidence
  9. A comment on effect of plant extracts on Alzheimer’s disease: An insight into therapeutic avenues
  10. Dietary approach for cognitive and behavioral problems in dementia

Dipsacus asper extract

  1. The herbal medicine Dipsacus asper Wall extract reduces the cognitive deficits and overexpression of β-amyloid protein induced by aluminum exposure
  2. Effects of Extract from Dipsacus Asperoides on Anti-oxidation and Learningmemory Abilities in D-Galactose-induced Mice
  3. [The effect of Wu-He Dipsacus asper on mice-aging model induced by D-galactose].
  4. Antioxidant activity of caffeoyl quinic acid derivatives from the roots of Dipsacus asper Wall
  5. The effects of the total saponin of Dipsacus asperoides on the damage of cultured neurons induced by β-amyloid protein 25–35
  6. Effects of dipsacus asper on β AP deposit in hippocampal structure of the rat AD disease model
  7. The Treatment of Brain Inflammation in Alzheimer’s Disease. Can Traditional Medicines Help?
  8. The herbal medicine Dipsacus asper wall extract reduces the cognitive deficits and overexpression of beta-amyloid protein induced by aluminum exposure.
  9. Neuroprotective effects of 3,5‐dicaffeoylquinic acid on hydrogen peroxide‐induced cell death in SH‐SY5Y cells
  10. Antispasmodic and Antiabortifacient Effects of Total Alkaloids from Dipsacus asperoides on Pregnant Rats


  1. Protective effect of green tea polyphenol EGCG against neuronal damage and brain edema after unilateral cerebral ischemia in gerbils
  2. Neurorescue Activity, APP Regulation and Amyloid-β Peptide Reduction by Novel Multi-Functional Brain Permeable Iron- Chelating- Antioxidants,M-30 and Green Tea Polyphenol, EGCG
  3. Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice
  4. Green Tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice
  5. Anxiolytic properties of green tea polyphenol (−)-epigallocatechin gallate (EGCG)
  6. Probing the infiltrating character of brain tumors: inhibition of RhoA/ROK‐mediated CD44 cell surface shedding from glioma cells by the green tea catechin EGCg
  7. Green Tea Epigallocatechin-3-Gallate (EGCG) and Other Flavonoids Reduce Alzheimer’s Amyloid-Induced Mitochondrial Dysfunction
  8. Beneficial Effects of Dietary EGCG and Voluntary Exercise on Behavior in an Alzheimer’s Disease Mouse Model
  9. Synergistic Effect of L-Carnosine and EGCG in the Prevention of Physiological Brain Aging
  10. Epigallocatechin-3-Gallate (EGCG) Attenuates Traumatic Brain Injury by Inhibition of Edema Formation and Oxidative Stress

Eryngium campestre L. aerial parts

  1. Anti-Alzheimer, Antioxidant Activities and Flavonol Glycosides of Eryngium campestre L.
  2. Cytotoxic Essential Oils from Eryngium campestre and Eryngium amethystinum (Apiaceae) Growing in Central Italy
  3. Chapter 7 – Eryngium campestre L.: Polyphenolic and Flavonoid Compounds; Applications to Health and Disease
  4. Improvement in Long-Term Memory following Chronic Administration of Eryngium planum Root Extract in Scopolamine Model: Behavioral and Molecular Study
  5. Preliminary Phytochemical Screening, Analgesic and Anti-inflammatory effect of Eryngium pyramidale Boiss. & Husson Essential Oil in Male Rat
  6. Flavonoids from the aerial parts of Eryngium campestre L. with antioxidant and anti-alzheimer activities
  8. Investigation of In Vitro Antioxidant Activity and In Vivo Antipyretic and Anti-Inflammatory Activities of Algerian Eryngium campestre L.
  9. Inhibitory potential of some Romanian medicinal plants against enzymes linked to neurodegenerative diseases and their antioxidant activity
  10. Comparative evaluation of the anti-inflammatory and antinociceptive activity of Turkish Eryngium species

Evodia rutaecarpa

  1. Novel Anticholinesterase and Antiamnesic Activities of Dehydroevodiamine, a Constituent of Evodia rutaecarpa
  2. Cytotoxicity and p-glycoprotein modulating effects of quinolones and indoloquinazolines from the Chinese herb Evodia rutaecarpa
  3. Increased Feline Cerebral Blood Flow Induced by Dehydroevodiamine Hydrochloride from Evodia rutaecarpa
  4. Antianoxic action of evodiamine, an alkaloid in Evodia rutaecarpa fruit
  5. Pharmacological Effects of Rutaecarpine, an Alkaloid Isolated from Evodia rutaecarpa
  6. Effects of Evodia rutaecarpa and Rutaecarpine on the Pharmacokinetics of Caffeine in Rats
  7. Herb–drug interaction of Evodia rutaecarpa extract on the pharmacokinetics of theophylline in rats
  8. Antianoxic Action and Active Constituents of Evodiae Fructus
  9. Plants with traditional uses and activities, relevant to the management of Alzheimer’s disease and other cognitive disorders
  10. Dehydroevodiamine attenuates tau hyperphosphorylation and spatial memory deficit induced by activation of glycogen synthase kinase-3 in rats

Evolvulus alsinoides

  1. Effect of Evolvulus alsinoides Linn. on learning behavior and memory enhancement activity in rodents
  2. Evaluation of Evolvulus alsinoides Linn. for Anthelmintic and Antimicrobial Activities
  3. Adaptogenic and anti-amnesic properties of Evolvulus alsinoides in rodents
  4. Anxiolytic activity of Evolvulus alsinoides and Convulvulus pluricaulis in rodents
  5. Anti-stress Constituents of Evolvulus alsinoides: An Ayurvedic Crude Drug
  6. Review of Ethnomedicinal Uses and Pharmacology of Evolvulus alsinoides Linn.
  7. Amelioration of intracerebroventricular streptozotocin induced cognitive impairment by Evolvulus alsinoides in rats: In vitro and in vivo evidence
  8. Comparative Evaluation of Ethanolic Extracts of Bacopa monnieri, Evolvulus alsinoides, Tinospora cordifolia and their Combinations on Cognitive Functions in Rats
  10. Effects of “Mentat” on Memory Span, Attention, Galvanic Skin Resistance (GSR) and Muscle Action Potential (EMG) among Normal Adults

Ferulic Acid

  1. Ferulic acid provides neuroprotection against oxidative stress-related apoptosis after cerebral ischemia/reperfusion injury by inhibiting ICAM-1 mRNA expression in rats
  2. Ferulic Acid Reduces Cerebral Infarct Through Its Antioxidative and Anti-Inflammatory Effects Following Transient Focal Cerebral Ischemia in Rats
  3. Ferulic acid ethyl ester protects neurons against amyloid β‐ peptide(1–42)‐induced oxidative stress and neurotoxicity: relationship to antioxidant activity
  4. Ferulic acid prevents the cerebral ischemic injury-induced decrease of Akt and Bad phosphorylation
  5. Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies
  6. Potent protection of ferulic acid against excitotoxic effects of maternal intragastric administration of monosodium glutamate at a late stage of pregnancy on developing mouse fetal brain
  7. Ferulic acid inhibits nitric oxide-induced apoptosis by enhancing GABAB1 receptor expression in transient focal cerebral ischemia in rats
  8. Ferulic acid: Pharmacological and toxicological aspects
  9. Trans-ferulic acid-based solid lipid nanoparticles and their antioxidant effect in rat brain microsomes
  10. Ferulic acid modulates nitric oxide synthase expression in focal cerebral ischemia

Ficus carica leaves

  1. Hepatoprotective Activity of Ficus carica Leaf Extract on Rifampicin-Induced Hepatic Damage in Rats
  2. Protection of Fibroblasts (NIH-3T3) against Oxidative Damage by Cyanidin-3-rhamnoglucoside Isolated from Fig Fruits (Ficus carica L.)
  3. Protective Effects of Latex of Ficus carica L. against Lead Acetate-Induced Hepatotoxicity in Rats
  4. Central nervous system activity of an aqueous acetonic extract of Ficus carica L. in mice
  6. The effect of hydro-alcoholic extract of dried Ficus carica on spatial learning and memory in mice
  7. Comparative effects of ethanolic extracts of Ficus carica and Mucuna pruriens leaves on haematological parameters in albino rats
  8. Long-Term Dietary Supplementation of Pomegranates, Figs and Dates Alleviate Neuroinflammation in a Transgenic Mouse Model of Alzheimer’s Disease
  9. Consumption of fig fruits grown in Oman can improve memory, anxiety, and learning skills in a transgenic mice model of Alzheimer’s disease
  10. Fig (Ficus Carica L.) identification based on mutual information and neural networks


  1. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson’s disease
  2. Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity
  3. Cell and brain tissue imaging of the flavonoid fisetin using label-free two-photon microscopy
  4. Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer’s disease transgenic mice
  5. Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin
  6. Fisetin alleviates early brain injury following experimental subarachnoid hemorrhage in rats possibly by suppressing TLR 4/NF-κB signaling pathway
  7. Dietary flavonoid fisetin regulates aluminium chloride-induced neuronal apoptosis in cortex and hippocampus of mice brain
  8. The antidepressant-like effect of fisetin involves the serotonergic and noradrenergic system
  9. Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory
  10. Neuroprotective Effect of Fisetin Against Amyloid-Beta-Induced Cognitive/Synaptic Dysfunction, Neuroinflammation, and Neurodegeneration in Adult Mice

Fructus psoraleae

  1. Inhibitive effects of Fructus Psoraleae extract on dopamine transporter and noradrenaline transporter
  2. Plasma pharmacokinetics and cerebral nuclei distribution of major constituents of Psoraleae fructus in rats after oral administration
  3. Isobavachalcone Attenuates MPTP-Induced Parkinson’s Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway
  4. Multi-Target Anti-Alzheimer Activities of Four Prenylated Compounds from Psoralea Fructus
  5. Composition containing an extract of fructus psoraleae for inhibiting anxiety and depression, improving memory and treating dementia
  6. Effects of Qibao Meiran Oral Liquid on SOD activity and carbonyl protein content in brain tissue of mice
  7. Effect of Psoraleae Fructus and Rehmanniae Radix on Body Temperature and ATPase Activity in Rats
  8. [Study on tissue distribution of psoraleae fructus decoction in rats]
  9. Brain Food for Alzheimer-Free Ageing: Focus on Herbal Medicines
  10. The effects of different compatibilities of Qing’e formula on scopolamine-induced learning and memory impairment in the mouse

Galanthus nivalis L

  1. Inhibition of Acetylcholinesterase Activity in Human Brain Tissue and Erythrocytes by Galanthamine, Physostigmine and Tacrine
  2. Galanthamine: pharmacokinetics, tissue distribution and cholinesterase inhibition in brain of mice
  3. Galanthamine from snowdrop—the development of a modern drug against Alzheimer’s disease from local Caucasian knowledge
  4. Pharmacokinetic behavior and efficiency of acetylcholinesterase inhibition in rat brain after intranasal administration of galanthamine hydrobromide loaded flexible liposomes
  5. Galanthamine.
  6. Physostigmine, galanthamine and codeine act as ‘noncompetitive nicotinic receptor agonists’ on clonal rat pheochromocytoma cells
  7. Reversal of Central Anticholinergic Syndrome by Galanthamine
  8. Selective inhibition of human acetylcholinesterase by galanthamine in vitro and in vivo
  9. Review of the acetylcholinesterase inhibitor galanthamine
  10. Pharmacological evaluation of novel Alzheimer’s disease therapeutics: acetylcholinesterase inhibitors related to galanthamine.

Gastrodia elata Blume

  1. Gastrodia elata Blume and an Active Component, p-Hydroxybenzyl Alcohol Reduce Focal Ischemic Brain Injury through Antioxidant Related Gene Expressions
  2. 4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain
  3. Anti-inflammatory and anti-angiogenic activities of Gastrodia elata Blume
  4. Protective effects of Gastrodia elata Blume on MPP+-induced cytotoxicity in human dopaminergic SH-SY5Y cells
  5. Neuroprotective Effects of Vanillyl Alcohol in Gastrodia elata Blume Through Suppression of Oxidative Stress and Anti-Apoptotic Activity in Toxin-Induced Dopaminergic MN9D Cells
  6. Protective effects of several components of Gastrodia elata on lipid peroxidation in gerbil brain homogenates
  7. Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities
  8. Therapeutic potential of Gastrodia elata Blume for the treatment of Alzheimer’s disease
  9. Neuropharmacological Potential of Gastrodia elata Blume and Its Components
  10. Anti-depressant effects of Gastrodia elata Blume and its compounds gastrodin and 4-hydroxybenzyl alcohol, via the monoaminergic system and neuronal cytoskeletal remodeling


  1. Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide
  2. Ginkgo biloba prevents mobile phone-induced oxidative stress in rat brain
  3. Neuroprotective effects of Ginkgo biloba extract in brain ischemia are mediated by inhibition of nitric oxide synthesis
  4. Neuroprotective effects of bilobalide, a component of the Ginkgo biloba extract (EGb 761), in gerbil global brain ischemia
  5. Ginkgo Biloba Extract (EGb 761) Independently Improves Changes in Passive Avoidance Learning and Brain Membrane Fluidity in the Aging Mouse
  6. Effect of an extract of Ginkgo biloba on rat brain energy metabolism in hypoxia
  7. Neuroprotective Effects of Bilobalide, a Component of Ginkgo biloba Extract (EGb 761®) in Global Brain Ischemia and in Excitotoxicity-induced Neuronal Death
  8. Effects of ginkgo biloba constituents related to protection against brain damage caused by hypoxia
  9. The pharmacological effects of Ginkgo Biloba, a plant extract, on the brain of dementia patients in comparison with tacrine
  10. Plasma Levels and Distribution of Flavonoids in Rat Brain after Single and Repeated Doses of Standardized Ginkgo biloba Extract EGb 761

Glycyrrhizae Radix

  1. Effects of Glycyrrhizae Radix on Repeated Restraint Stress-induced Neurochemical and Behavioral Responses
  2. Antitussive principles of Glycyrrhizae radix, a main component of the Kampo preparations Bakumondo-to (Mai-men-dong-tang)
  3. Pharmacokinetic and pharmacodynamic profiles of the antitussive principles of Glycyrrhizae radix (licorice), a main component of the Kampo preparation Bakumondo-to (Mai-men-dong-tang)
  4. Inhibitory effects of glycyrrhizae radix and its active component, isoliquiritigenin, on Aβ(25–35)-induced neurotoxicity in cultured rat cortical neurons
  5. Glycyrrhizae Radix attenuates peroxynitrite-induced renal oxidative damage through inhibition of protein nitration
  6. Cytoprotective Activity of Glycyrrhizae radix Extract against Arsenite-Induced Cytotoxicity
  7. The influence of traditional herbal formulas on cytokine activity
  8. Neuroprotective Effects of Constituents of the Oriental Crude Drugs, Rhodiola sacra, R. sachalinensis and Tokaku-joki-to, against Beta-amyloid Toxicity, Oxidative Stress and Apoptosis
  9. Repair of amyloid β(25–35)-induced memory impairment and synaptic loss by a Kampo formula, Zokumei-to
  10. Anti-aging Effects of The Traditional Chinese Medicine Bu-Zhong-Yi-Qi-Tang in Mice


  1. [Effects of Goutengsan on model of Alzheimer dementia in rats by AlCl3]
  2. Effects of Goutengsan on Cerebral Blood Flow in Anaesthesia Dogs
  3. Components of Goutengsan in Rat Plasma by Microdialysis Sampling and Its Protection on Aβ1–42-Induced PC12 Cells Injury
  4. Effects of Goutengsan Extract on Mouse Models of Learning and Memory Disorders
  5. Effect of Jiannaoshengzhi Oral Liquid in Alzheimer′s disease on rat
  8. Brain Oxidative Stress as Basic Target of Antioxidant Traditional Oriental Medicines
  9. Herbal medicine for dementia: a systematic review
  10. Research and future trends in the pharmaceutical development of medicinal herbs from Chinese medicine

Grape seed extract

  1. Protective Effects of Grape Seed Proanthocyanidins and Selected Antioxidants against TPA-Induced Hepatic and Brain Lipid Peroxidation and DNA Fragmentation, and Peritoneal Macrophage Activation in Mice
  2. Consumption of Grape Seed Extract Prevents Amyloid-β Deposition and Attenuates Inflammation in Brain of an Alzheimer’s Disease Mouse
  3. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention
  4. Grape Seed Proanthocyanidin Extract (GSPE) and antioxidant defense in the brain of adult rats.
  5. Proteomics Analysis of Rat Brain Protein Modulations by Grape Seed Extract
  6. Grape seed extract suppresses lipid peroxidation and reduces hypoxic ischemic brain injury in neonatal rats
  7. Direct in vivo Evidence of Protective Effects of Grape Seed Procyanidin Fractions and Other Antioxidants against Ethanol-Induced Oxidative DNA Damage in Mouse Brain Cells
  8. Proteomics analysis of the actions of grape seed extract in rat brain: Technological and biological implications for the study of the actions of psychoactive compounds
  9. Grape seed proanthocyanidin lowers brain oxidative stress in adult and middle-aged rats
  10. Grape Seed Extract Given Three Hours After Injury Suppresses Lipid Peroxidation and Reduces Hypoxic-Ischemic Brain Injury in Neonatal Rats

Green tea extract

  1. Green tea catechins as brain‐permeable, natural iron chelators‐antioxidants for the treatment of neurodegenerative disorders
  2. Protective effect of green tea against lipid peroxidation in the rat liver, blood serum and the brain
  3. Neuroprotective effect of green tea extract in experimental ischemia-reperfusion brain injury
  4. Simultaneous Manipulation of Multiple Brain Targets by Green Tea Catechins: A Potential Neuroprotective Strategy for Alzheimer and Parkinson Diseases
  5. Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A
  6. Green Tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice
  7. Protective effects of the green tea polyphenol (−)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils
  8. Suppressive effect of green tea catechins on morphologic and functional regression of the brain in aged mice with accelerated senescence (SAMP10)
  9. Neurological mechanisms of green tea polyphenols in Alzheimer’s and Parkinson’s diseases
  10. Protective effect of green tea polyphenol (‐)‐epigallocatechin gallate and other antioxidants on lipid peroxidation in gerbil brain homogenates

Hericium erinaceum

  1. Nerve Growth Factor-Inducing Activity of Hericium erinaceus in 1321N1 Human Astrocytoma Cells
  2. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double‐blind placebo‐controlled clinical trial
  3. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake
  4. Protective Effects of Hericium erinaceus Mycelium and Its Isolated Erinacine A against Ischemia-Injury-Induced Neuronal Cell Death via the Inhibition of iNOS/p38 MAPK and Nitrotyrosine
  5. Effect of an exo-polysaccharide from the culture broth of Hericium erinaceus on enhancement of growth and differentiation of rat adrenal nerve cells
  6. Hericenones and erinacines: stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus
  7. Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice
  8. Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis
  9. Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
  10. Hericium erinaceus, an amazing medicinal mushroom


  1. Hesperidin, an antioxidant flavonoid, prevents acrylonitrile‐induced oxidative stress in rat brain
  2. Hesperidin pretreatment protects hypoxia–ischemic brain injury in neonatal rat
  3. Protective Effect of Hesperidin, a Citrus Bioflavonoid, on Diabetes-Induced Brain Damage in Rats
  4. Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke
  5. Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by D-galactose in rat brain
  6. Hesperidin protects brain and sciatic nerve tissues against cisplatin-induced oxidative, histological and electromyographical side effects in rats
  7. Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice
  8. Hesperidin ameliorates heavy metal induced toxicity mediated by oxidative stress in brain of Wistar rats
  9. Hesperidin attenuates brain biochemical changes of irradiated rats
  10. Potential neuroprotective effects of hesperidin on 3-nitropropionic acid-induced neurotoxicity in rats


  1. [Effect of water extract of Poria on cytosolic free calcium concentration in brain nerve cells of neonatal rats]
  2. Chemical Constituents and Pharmacological Properties of Poria cocos
  3. Urinary metabonomic study of the surface layer of Poria cocos as an effective treatment for chronic renal injury in rats
  4. Pharmacological Mechanisms and Advancement of Poria cocos
  5. A Novel Immunomodulatory Protein from Poria cocos Induces Toll-like Receptor 4-Dependent Activation within Mouse Peritoneal Macrophages
  6. Antiepileptic activity of total triterpenes isolated from Poria cocos is mediated by suppression of aspartic and glutamic acids in the brain
  7. Observation on the effects of Chinese medicine zhenxuanyin for improving cerebral blood flow in rats with cerebral ischemia
  8. Anti-amnesic effect of Chong–Myung–Tang on scopolamine-induced memory impairments in mice
  9. Effects of triterpenoids from Poria cocos Wolf on the serotonin type 3A receptor-mediated ion current in Xenopus oocytes
  10. The Use of Herbal Medicine in Alzheimer’s Disease—A Systematic Review

Huperzine A

  1. Huperzine A protects isolated rat brain mitochondria against β-amyloid peptide
  2. Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia–ischemia
  3. Comparison of the effects of natural and synthetic huperzine-A on rat brain cholinergic function in vitro and in vivo
  4. Comparative studies of huperzine A, donepezil, and rivastigmine on brain acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine levels in freely-moving rats
  5. Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer’s disease
  6. Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by β-amyloid protein-(1–40) in rat
  7. [Preparation of huperzine A nasal in situ gel and evaluation of its brain targeting following intranasal administration]
  8. Comparative Studies of Huperzine A, E2020, and Tacrine on Behavior and Cholinesterase Activities
  9. Anticholinesterase effects of huperzine A, E2020, and tacrine in rats.
  10. Drug brain distribution following intranasal administration of Huperzine A in situ gel in rats

Hypericum perforatum extract

  1. Hypericum perforatum extract demonstrates antioxidant properties against elevated rat brain oxidative status induced by amnestic dose of scopolamine
  2. Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex
  3. Effect of the Hypericum Perforatum Extract on Serotonin Turnover in the Mouse Brain
  4. St John’s wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties
  5. Serotonin, Norepinephrine and Dopamine Involvement in the Antidepressant Action of Hypericum Perforatum
  6. The antidepressant mechanism of Hypericum perforatum
  7. St. John’s Wort Extract Ze 117 (Hypericum perforatum) Inhibits Norepinephrine and Serotonin Uptake into Rat Brain Slices and Reduces β-Adrenoceptor Numbers on Cultured Rat Brain Cells
  8. Hypericum perforatum as a nootropic drug: enhancement of retrieval memory of a passive avoidance conditioning paradigm in mice
  9. Alleviation by Hypericum perforatum of the stress-induced impairment of spatial working memory in rats
  10. Effects of Hypericum perforatum extract on diabetes‐induced learning and memory impairment in rats

Ipomoea tricolor (Heavenly Blue) leaf extract

  1. Flavones from Heavenly Blue as modulators of Alzheimer’s amyloid-beta peptide (Aβ) production

Isorhamnetin (from Tagetes lucida)

  1. The protective role of isorhamnetin on human brain microvascular endothelial cells from cytotoxicity induced by methylglyoxal and oxygen–glucose deprivation
  2. Treatment with Isorhamnetin Protects the Brain Against Ischemic Injury in Mice
  3. Quercetin and isorhamnetin aglycones are the main metabolites of dietary quercetin in cerebrospinal fluid
  4. Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats
  5. Inhibitory Effects of Dropwort (Oenanthe javanica) Extracts on Memory Impairment and Oxidative Stress and the Qualitative Analysis of Isorhamnetin in the Extracts
  7. Isorhamnetin mitigates learning and memory disturbances in streptozotocin-induced diabetic rats
  9. Isorhamnetin, A Flavonol Aglycone from Ginkgo biloba L., Induces Neuronal Differentiation of Cultured PC12 Cells: Potentiating the Effect of Nerve Growth Factor
  10. Protective effects of Nitraria retusa extract and its constituent isorhamnetin against amyloid β-induced cytotoxicity and amyloid β aggregation


  1. Blood micromolar concentrations of kaempferol afford protection against ischemia/reperfusion-induced damage in rat brain
  2. Neuroprotective Effect of Kaempferol Glycosides against Brain Injury and Neuroinflammation by Inhibiting the Activation of NF-κB and STAT3 in Transient Focal Stroke
  3. Identification of Kaempferol as a Monoamine Oxidase Inhibitor and Potential Neuroprotectant in Extracts of Ginkgo Biloba Leaves
  4. Improved blood–brain barrier distribution: Effect of borneol on the brain pharmacokinetics of kaempferol in rats by in vivo microdialysis sampling
  5. Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson’s disease
  6. Neuroprotective Effect of Kaempferol against a 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Mouse Model of Parkinson’s Disease
  7. Protective Effects of Kaempferol (3,4′,5,7-tetrahydroxyflavone) against Amyloid Beta Peptide (Aβ)-Induced Neurotoxicity in ICR Mice
  8. Validation of UHPLC–MS/MS methods for the determination of kaempferol and its metabolite 4-hydroxyphenyl acetic acid, and application to in vitro blood-brain barrier and intestinal drug permeability studies
  9. Kaempferol induces apoptosis in glioblastoma cells through oxidative stress
  10. Kaempferol blocks oxidative stress in cerebellar granule cells and reveals a key role for reactive oxygen species production at the plasma membrane in the commitment to apoptosis

Laurus nobilis

  1. Anticonvulsant activity of the leaf esential oil of Laurus nobilis against pentylenetetrazole- and maximal electroshock-induced seizures
  2. Amelioration of Oxygen and Glucose Deprivation-Induced Neuronal Death by Chloroform Fraction of Bay Leaves (Laurus nobilis)
  3. Analgesic and anti‐inflammatory activity of the leaf essential oil of Laurus nobilis Linn.
  4. Isolation and Characterization of Alkyl Peroxy Radical Scavenging Compound from Leaves of Laurus nobilis
  5. Neuroprotective Effect of the n-Hexane Extracts of Laurus nobilis L. in Models of Parkinson’s Disease
  6. Neuroprotective Potential of Laurus nobilis Antioxidant Polyphenol-Enriched Leaf Extracts
  7. Antioxidant and antibacterial activity of essential oil and extracts of bay laurel Laurus nobilis Linnaeus (Lauraceae) from Portugal
  9. Aluminum phosphide-induced genetic and oxidative damages in rats: attenuation by Laurus nobilis leaf extract
  10. Aluminium phosphide-induced genetic and oxidative damages in vitro: Attenuation by Laurus nobilis L. leaf extract

Lavandula Angustifolia

  1. Effect of lavender oil (Lavandula angustifolia) on cerebral edema and its possible mechanisms in an experimental model of stroke
  2. Comparison of Lavandula angustifolia Mill. tincture and imipramine in the treatment of mild to moderate depression: a double-blind, randomized trial
  3. Anxiolytic effects of Lavandula angustifolia odour on the Mongolian gerbil elevated plus maze
  4. The effects of aqueous extract of Lavandula angustifolia flowers in glutamate-induced neurotoxicity of cerebellar granular cell culture of rat pups
  5. Neurodepressive effects of the essential oil of Lavandula angustifolia Mill
  6. Clearance of amyloid beta plaques from brain of Alzheimeric rats by lavandula angustifolia
  7. The effect of Lavandula angustifolia in the treatment of mild to moderate depression
  8. Protein Drug Targets of Lavandula angustifolia on treatment of Rat Alzheimer’s Disease
  9. A randomized, controlled cross-over trial of dermally-applied lavender (Lavandula angustifolia) oil as a treatment of agitated behaviour in dementia
  10. Aqueous extract of Lavandula angustifolia alter protein expression in Alzheimer rats

Lawsonia inermis

  1. Anti-Inflammatory, Antipyretic, and Analgesic Effects of Lawsonia inermis L. (Henna) in Rats
  2. Evaluation of analgesic, anti-inflammatory and CNS depressant activities of methanolic extract of Lawsonia inermis barks in mice
  3. Comparative Tissue Stainability of Lawsonia inermis (Henna) and Eosin as Counterstains to Hematoxylin in Brain Tissues
  4. Anti-inflammatory and Antinociceptive Activity of Lawsonia inermis Linn Alcoholic Extract in Rats
  5. Effect of Lawsonia inermis on memory and behaviour mediated via monoamine neurotransmitters
  7. Assessment of antioxidant, anti-inflammatory, anti-cholinesterase and cytotoxic activities of Henna (Lawsonia inermis) flowers
  8. Memory enhancing activity of Lawsonia inermis Linn. leaves against scopolamine induced memory impairment in Swiss albino mice
  10. Lawsonia inermis L. (henna): Ethnobotanical, phytochemical and pharmacological aspects

lithium orotate

  1. Plasma and brain pharmacokinetics of previously unexplored lithium salts
  2. Multipath nutritional supplement for memory, cognition, and coordination
  3. Lithium and a beta-secretase inhibitor for the treatment of alzheimer’s disease
  4. Potential Role for Lithium (Orotate) in Preventing
    Alzheimer’s Disease
  5. Lithium: Under-Appreciated Brain Nutrient & Protector
  6. Low dose lithium treatment in patients with mental illness
  7. Lithium concentrations and clinical responses
  8. Lithium as a Nutrient
  9. Is there a role for lithium orotate in psychiatry?
  10. Nutritional Lithium
  11. Inhibition of GSK3 by lithium, from single molecules to signaling networks
  12. Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes.
  13. Disparate Effects of Lithium and a GSK-3 Inhibitor on Neuronal Oscillatory Activity in Prefrontal Cortex and Hippocampus
  14. Lithium reduces Gsk3b mRNA levels: implications for Alzheimer Disease.
  15. Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
  16. Lithium: The Cinderella Story about a Mineral That May Prevent Alzheimer’s Disease
  17. Inhibiting the GSK-3 Enzyme with Lithium Orotate May Slow Brain Aging and Dementia
  18. New Method to Slow Brain Aging
  19. Glycogen Synthase Kinase-3 in Neurodegeneration and Neuroprotection: Lessons from Lithium
  20. Beneficial synergistic effects of microdose lithium with pyrroloquinoline quinone in an Alzheimer’s disease mouse model
  21. The Role of Glycogen Synthase Kinase-3 (GSK-3) in Alzheimer’s Disease

Lotus Root Extract (LRE)

  1. The Mechanism of Lotus Root Extract (LRE) as Neuro-Protective Effect in Alzheimer Disease (AD)
  2. Lotus Root Extract Stimulates BDNF Gene Expression Through Potential Mechanism Depending on HO-1 Activity in C6 Glioma Cells
  3. Benefits of Lotus Root And Its Side Effects
  4. Lotus Root: The Herb that Supports the Brain, Gut & Heart
  5. 9 Amazing Benefits of Lotus Root
  6. 6 Lotus Root (Kamal Kakdi) Benefits: From Weight Loss to Reducing Stress and More!
  7. 11 Amazing Health Benefits of Lotus Root
  8. 15 Health Benefits of Lotus Root, According to Science
  9. 9 Incredible Health Benefits of Lotus Root – Practical Reasons Why You Should Eat More Lotus Root
  10. Lotus root (藕) nutrition facts and health benefits

Lycii Fructus fruit of Lycium chinense Miller

  1. Protective effect of Fructus Lycii polysaccharides against time and hyperthermia-induced damage in cultured seminiferous epithelium
  2. Characterization of the effects of anti-aging medicine Fructus lycii on β-amyloid peptide neurotoxicity
  3. Anti-aging effect of polypeptides from Fructus Lycii on D-gal induced aging model mice and the possible mechanism.
  4. Effect of Herba Epimedii and Fructus Lycii on mitochondrial DNA deletion, activity of respiratory chain enzyme complexes and ATP synthesis in aged rats
  5. Lycium barbarum Extracts Protect the Brain from Blood-Brain Barrier Disruption and Cerebral Edema in Experimental Stroke
  6. Neuroprotective effects of LBP on brain ischemic reperfusion neurodegeneration
  7. Research Advances on the Anti-aging Profile of Fructus lycii: an Ancient Chinese Herbal Medicine
  8. Effects of fructus lycii on learning and memory of D-galactose induced aging mice
  9. Lycium barbarum Polysaccharides Prevent Memory and Neurogenesis Impairments in Scopolamine-Treated Rats
  10. Efficacy of ethanol extract of Fructus lycii and its constituents lutein/zeaxanthin in protecting retinal pigment epithelium cells against oxidative stress

Mandukaparni (Centella asiatica Linn.)

  1. Histological Study of Action of Alcohol on Hippocampal Region of Brain and Use of “Mandukaparni” as a Brain Rejuvenator
  3. Neuronutrient impact of Ayurvedic Rasayana therapy in brain aging
  4. Chapter 18 – Ayurvedic Approach to Food and Dietary Supplements for the Brain and Neurologic Health
  5. Centella asiatica (linn) induced behavioural changes during growth spurt period in neonatal rats
  6. Neuroprotective Effects of Centella asiatica against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress
  7. Effect of Centella asiatica leaf powder on oxidative markers in brain regions of prepubertal mice in vivo and its in vitro efficacy to ameliorate 3-NPA-induced oxidative stress in mitochondria
  8. Emerging role of Centella asiatica in improving age-related neurological antioxidant status
  9. Centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats
  10. Changes in brain biogenic amines and haem biosynthesis and their response to combined administration of succimers and Centella asiatica in lead poisoned rats


  1. H2O2 induced lipid peroxidation in rat brain homogenates is greatly reduced by melatonin
  2. Brain Serotonin Concentration: Elevation Following Intraperitoneal Administration of Melatonin
  3. Inhibition of dopamine release by melatonin: regional distribution in the rat brain
  4. Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor
  5. Melatonin stimulates brain glutathione peroxidase activity
  6. On the effect of melatonin upon human brain. Its possible therapeutic implications
  7. Localization and characterization of melatonin receptors in rodent brain by in vitro autoradiography
  8. Melatonin increases gene expression for antioxidant enzymes in rat brain cortex
  9. Melatonin receptors are for the birds: Molecular analysis of two receptor subtypes differentially expressed in chick brain
  10. brain cells

Melissa officinalis extract

  1. Modulation of Mood and Cognitive Performance Following Acute Administration of Single Doses of Melissa Officinalis (Lemon Balm) with Human CNS Nicotinic and Muscarinic Receptor-Binding Properties
  2. Neuroprotective properties of Melissa officinalis after hypoxic-ischemic injury both in vitro and in vivo
  3. Attenuation of Laboratory-Induced Stress in Humans After Acute Administration of Melissa officinalis (Lemon Balm)
  4. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: a double blind, randomised, placebo controlled trial
  5. Protective effect of Melissa officinalis aqueous extract against Mn-induced oxidative stress in chronically exposed mice
  6. Effects of chronic administration of Melissa officinalis L. extract on anxiety-like reactivity and on circadian and exploratory activities in mice
  7. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm)
  8. Chemical composition, antioxidant and anticholinesterase activity of Melissa officinalis
  9. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances
  10. Effects of Melissa officinalis L. (Lemon Balm) Extract on Neurogenesis Associated with Serum Corticosterone and GABA in the Mouse Dentate Gyrus

Mentha piperita

  2. Neuroprotective and neurochemical properties of mint extracts
  3. Silver nanoparticles from leaf extract of Mentha piperita: Eco-friendly synthesis and effect on acetylcholinesterase activity
  4. Tolerance, bioavailability, and potential cognitive health implications of a distinct aqueous spearmint extract
  7. Enhancing Athletic Performance through the Administration of Peppermint Odor
  8. Cognitive Enhancement Through Stimulation of the Chemical Senses
  9. Effect of peppermint and eucalyptus oil preparations on neurophysiological and experimental algesimetric headache parameters
  10. Effects of Peppermint Scent Administration on Cognitive Video Game Performance

Mimosa pudica Linn

  2. Mimosa pudica may possess antidepressant actions in the rat
  3. “Neural capacity” in Mimosa pudica: a review
  4. Effect of Mimosa pudica (Linn.) extract on anxiety behaviour and GABAergic regulation of 5-HT neuronal activity in the mouse
  5. Inhalational and local anesthetics reduce tactile and thermal responses inmimosa pudica
  6. Nootropic Studies of Ethanolic Extract of Mimosa Pudica Linn. In Albino Wistar Rats
  7. Adaptogenic and nootropic activity of Mimosa pudica in albino wistar rats
  8. Effects of Mimosa pudica L. leaves extract on anxiety, depression and memory

Moringa oleifera

  1. lteration of brain monoamines & EEG wave pattern in rat model of Alzheimer’s disease & protection by Moringa oleifera
  2. Moringa oleifera: a food plant with multiple medicinal uses
  3. Central inhibitory effect of Moringa oleifera root extract: possible role of neurotransmitters.
  4. Cerebroprotective Effect of Moringa oleifera against Focal Ischemic Stroke Induced by Middle Cerebral Artery Occlusion
  5. Therapeutic effects of Moringa oleifera on arsenic-induced toxicity in rats
  6. Moringa oleifera Mitigates Memory Impairment and Neurodegeneration in Animal Model of Age-Related Dementia
  7. Effect of Moringa Oleifera in Experimental Model of Alzheimer’s Disease : Role of Antioxidants
  8. Moringa oleifera with promising neuronal survival and neurite outgrowth promoting potentials
  9. Role of Moringa oleifera in regulation of diabetes-induced oxidative stress
  10. Role of Moringa oleifera on enterochromaffin cell count and serotonin content of experimental ulcer model

Mulberry fruit extract

  1. Neuroprotective effects of the cyanidin-3-O-β-d-glucopyranoside isolated from mulberry fruit against cerebral ischemia
  2. Mulberry fruit protects dopaminergic neurons in toxin-induced Parkinson’s disease models
  3. Mulberry Fruit Extract Protects against Memory Impairment and Hippocampal Damage in Animal Model of Vascular Dementia
  4. Berry Fruit Enhances Beneficial Signaling in the Brain
  5. Neuroprotective effects of berry fruits on neurodegenerative diseases
  6. Study on Nutritional Components of Black Mulberry Fruit and Effects on Anti-oxidation
  7. Mulberry fruit ameliorates Parkinson’sdisease-related pathology by reducing α-synuclein and ubiquitin levels in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model
  9. Mori Folium and Mori Fructus Mixture Attenuates High-Fat Diet-Induced Cognitive Deficits in Mice
  10. Mori Fructus improves cognitive and neuronal dysfunction induced by beta-amyloid toxicity through the GSK-3β pathway in vitro and in vivo

Myrica cerifera (bayberrysouthern wax myrtle)

  1. Isolation of myricadiol, myricitrin, taraxerol, and taraxerone from Myrica cerifera L. root bark
  2. Taraxerol as a possible therapeutic agent on memory impairments and Alzheimer’s disease: Effects against scopolamine and streptozotocin-induced cognitive dysfunctions
  3. Top-leads from natural products for treatment of Alzheimer’s disease: docking and molecular dynamics study
  4. Nature as a source of metabolites with cholinesterase‐inhibitory activity: an approach to Alzheimer’s disease treatment
  5. Occurrence of taraxerol and taraxasterol in medicinal plants
  6. Anti-arrhythmic Medication Propafenone a Potential Drug for Alzheimer’s Disease Inhibiting Aggregation of Aβ: In Silico and in Vitro Studies
  7. In Silico and in Vitro Study of Binding Affinity of Tripeptides to Amyloid β Fibrils: Implications for Alzheimer’s Disease
  8. Nootropic and Anti-Alzheimer’s Actions of Medicinal Plants: Molecular Insight into Therapeutic Potential to Alleviate Alzheimer’s Neuropathology


  1. Myricetin and quercetin, the flavonoid constituents ofGinkgo biloba extract, greatly reduce oxidative metabolism in both resting and Ca2+-loaded brain neurons
  2. Neuroprotective effect of fraxetin and myricetin against rotenone-induced apoptosis in neuroblastoma cells
  3. Myricetin: A Naturally Occurring Regulator of Metal‐Induced Amyloid‐β Aggregation and Neurotoxicity
  4. Effect of fraxetin and myricetin on rotenone-induced cytotoxicity in SH-SY5Y cells: comparison with N-acetylcysteine
  5. Myricetin reduces 6-hydroxydopamine-induced dopamine neuron degeneration in rats
  6. Myricetin ameliorates brain injury and neurological deficits via Nrf2 activation after experimental stroke in middle-aged rats
  7. Myricetin ameliorates scopolamine-induced memory impairment in mice via inhibiting acetylcholinesterase and down-regulating brain iron
  8. In vivo investigation on the potential of galangin, kaempferol and myricetin for protection of d-galactose-induced cognitive impairment
  9. Mechanisms underlying the protective effects of myricetin and quercetin following oxygen-glucose deprivation-induced cell swelling and the reduction in glutamate uptake in glial cells
  10. Myricetin Attenuates Depressant-Like Behavior in Mice Subjected to Repeated Restraint Stress


  1. Determination of naringenin and its glucuronide conjugate in rat plasma and brain tissue by high-performance liquid chromatography
  2. Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway
  3. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson’s disease
  4. Effect of naringenin on brain insulin signaling and cognitive functions in ICV-STZ induced dementia model of rats
  5. Neuroprotective effect of naringenin is mediated through suppression of NF-κB signaling pathway in experimental stroke
  6. Naringenin and quercetin reverse the effect of hypobaric hypoxia and elicit neuroprotective response in the murine model
  7. Effect of Naringenin on Intracerebroventricular Streptozotocin-Induced Cognitive Deficits in Rat: A Behavioral Analysis
  8. Protective Effect of Naringenin in Experimental Ischemic Stroke: Down-Regulated NOD2, RIP2, NF-κB, MMP-9 and Up-Regulated Claudin-5 Expression
  9. Naringenin improves learning and memory in an Alzheimer’s disease rat model: Insights into the underlying mechanisms
  10. Naringenin promote apoptosis in cerebrally implanted C6 glioma cells

Nelumbo nucifera semen extract

  1. Nelumbo nucifera semen extract improves memory in rats with scopolamine-induced amnesia through the induction of choline acetyltransferase expression
  2. Novel effects of Nelumbo nucifera rhizome extract on memory and neurogenesis in the dentate gyrus of the rat hippocampus
  3. Attenuation of Acute and Chronic Restraint Stress-induced Perturbations in Experimental Animals by Nelumbo nucifera Gaertn
  4. Effects of Nelumbo nucifera Rhizome Extract on Cell Proliferation and Neuroblast Differentiation in the Hippocampal Dentate Gyrus in a Scopolamine‐induced Amnesia Animal Model
  5. An aporphine alkaloid from Nelumbo nucifera as an acetylcholinesterase inhibitor and the primary investigation for structure–activity correlations
  6. Improvement for High Fat Diet-Induced Hepatic Injuries and Oxidative Stress by Flavonoid-Enriched Extract from Nelumbo nucifera Leaf
  7. Cognitive Enhancing and Neuroprotective Effect of the Embryo of the Nelumbo nucifera Seed
  8. Selective Cholinesterase Inhibitory Activities of a New Monoterpene Diglycoside and Other Constituents from Nelumbo nucifera Stamens
  9. BACE1 and cholinesterase inhibitory activities of Nelumbo nucifera embryos
  10. Ameliorative effects of lotus seedpod proanthocyanidins on cognitive deficits and oxidative damage in senescence-accelerated mice

Nigella sativa

  1. Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus
  2. Fixed Oil of Nigella sativa and Derived Thymoquinone Inhibit Eicosanoid Generation in Leukocytes and Membrane Lipid Peroxidation
  3. A review on therapeutic potential of Nigella sativa: A miracle herb
  4. Protective effects of Nigella sativa oil on propoxur-induced toxicity and oxidative stress in rat brain regions
  5. Protective Effects of Nigella sativa on the Neuronal Injury in Frontal Cortex and Brain Stem After Chronic Toluene Exposure
  7. The effect of Nigella sativa oil against experimental allergic encephalomyelitis via nitric oxide and other oxidative stress parameters.
  8. Effects of Nigella sativa Oil and Thymoquinone on Oxidative Stress and Neuropathy in Streptozotocin-Induced Diabetic Rats
  9. Neuroprotective effects of Nigella sativa extract on cell death in hippocampal neurons following experimental global cerebral ischemia-reperfusion injury in rats
  10. The Effects of Nigella Sativa Hydro-alcoholic Extract on Memory and Brain Tissues Oxidative Damage after Repeated Seizures in Rats

Ocimum sanctum Linn. Leaf Extract

  1. Noise-Stress-Induced Brain Neurotransmitter Changes and the Effect of Ocimum sanctum (Linn) Treatment in Albino Rats
  2. Evaluation of antioxidant and neuroprotective effect of Ocimum sanctum on transient cerebral ischemia and long-term cerebral hypoperfusion
  3. Oxidative stress in brain and antioxidant activity of Ocimum sanctum in noise exposure
  4. Ocimum sanctum attenuates oxidative damage and neurological deficits following focal cerebral ischemia/reperfusion injury in rats
  5. Ameliorative effects of Ocimum sanctum in sciatic nerve transection-induced neuropathy in rats
  6. Exploring the potential effect of Ocimum sanctum in vincristine-induced neuropathic pain in rats
  7. Effect of Ocimum sanctum Linn on the changes in central cholinergic system induced by acute noise stress
  8. Ocimum sanctum Linn. Leaf Extracts Inhibit Acetylcholinesterase and Improve Cognition in Rats with Experimentally Induced Dementia
  9. Effects of Ocimum sanctum and Camellia sinensis on stress-induced anxiety and depression in male albino Rattus norvegicus
  10. Biogenic amine changes in brain regions and attenuating action of Ocimum sanctumin noise exposure

Ocimum tenuiflorum Linn

  1. Cholinergic basis of memory improving effect of Ocimum tenuiflorum Linn
  2. Efficacy of an Extract of Ocimum tenuiflorum (OciBest) in the Management of General Stress: A Double-Blind, Placebo-Controlled Study
  3. Therapeutic activities of Ocimum tenuiflorum accounted in last decade
  4. Evaluation of nootropic potential of Ocimum sanctum Linn. in mice
  5. Role of Ocimum sanctum in the experimental model of Alzheimer’s disease in rats
  6. Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview
  7. Tulsi – Ocimum sanctum: A herb for all reasons
  8. Diversified potentials of Ocimum sanctum Linn (Tulsi): An exhaustive survey
  9. Neuroprotective Effects of Hydroalcoholic Extract of Ocimum sanctum Against H2O2 Induced Neuronal Cell Damage in SH-SY5Y Cells via Its Antioxidative Defence Mechanism
  10. Effect of combination of Phyllanthus emblica, Tinospora cordifolia, and Ocimum sanctum on spatial learning and memory in rats


  1. Oleuropein Aglycone: A Possible Drug against Degenerative Conditions. In Vivo Evidence of its Effectiveness against Alzheimer’s Disease
  2. Oleuropein and derivatives from olives as Tau aggregation inhibitors
  3. Oleuropein aglycone counteracts Aβ42 toxicity in the rat brain
  4. Oleuropein Aglycone Protects Transgenic C. elegans Strains Expressing Aβ42 by Reducing Plaque Load and Motor Deficit
  5. Potential Therapeutic Effects of Oleuropein Aglycone in Alzheimer’s Disease
  6. Oleuropein aglycone and polyphenols from olive mill waste water ameliorate cognitive deficits and neuropathology
  7. Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight
  8. Cardioprotective and neuroprotective roles of oleuropein in olive
  9. Neuroprotective effects of oleuropein against cognitive dysfunction induced by colchicine in hippocampal CA1 area in rats
  10. Olive Oil Phenols as Promising Multi-targeting Agents Against Alzheimer’s Disease

Ophiopogon japonicus extract

  1. Ophiopogon japonicus
  2. The Ameliorating Effects of Cognition-enhancing Chinese Herbs on Scopolamine-and MK-801-induced Amnesia in Rats

Panax ginseng

  1. Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer
  2. Extracts of Ginkgo Biloba and Panax Ginseng Protect Brain Proteins from Free Radical Induced Oxidative Damage in Vitro
  3. Panax Ginseng Enhances Cognitive Performance in Alzheimer Disease
  4. Effects of Panax ginseng Root on the Vertical and Horizontal Motor Activities and on Brain Monoamine-Related Substances in Mice
  6. Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia
  7. The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers
  8. Protective effect of ginsenosides, active ingredients of Panax ginseng, on kainic acid-induced neurotoxicity in rat hippocampus
  9. Effects of Panax ginseng in Neurodegenerative Diseases
  10. Anti-stress Effects of Ginkgo biloba and Panax ginseng: a Comparative Study

Paullinia cupana (guarana) seeds

  1. Guarana (Paullinia cupana): toxic behavioral effects in laboratory animals and antioxidant activity in vitro
  2. Guarana (Paullinia cupana) ameliorates memory impairment and modulates acetylcholinesterase activity in Poloxamer-407-induced hyperlipidemia in rat brain
  3. An analysis of the role of paulinia cupana (Guaraná) in blood IL-1b and brain IL-6 levels as well as brain IL-6 and TNF-a mRNA expression in mice.
  4. The effects of long-term administration of guarana on the cognition of normal, elderly volunteers
  5. Improved cognitive performance and mental fatigue following a multi-vitamin and mineral supplement with added guaraná (Paullinia cupana)
  6. Neuroprotective Effects of Guarana (Paullinia cupana Mart.) against Vincristine in Vitro Exposure
  7. Pharmacological activity of Guarana (Paullinia cupana Mart.) in laboratory animals
  8. Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng
  9. Effectiveness of Guaraná (Paullinia cupana) for Postradiation Fatigue and Depression: Results of a Pilot Double-Blind Randomized Study
  10. Studies on Learning Ability Effects of Mixture of Five Kinds Water Soluble Propolis, Water Soluble Guarana. DHA, PS, PC) n Senescence-accelerated Mice (SAM)performance and subjective ratings of calmness in healthy young adults

Phaseolus vulgaris Extract

  1. Cholinergic and non-cholinergic projections from the rat basal forebrain revealed by combined choline acetyltransferase and Phaseolus vulgaris
  2. Phaseolus vulgaris L. Extract: Alpha-Amylase Inhibition against Metabolic Syndrome in Mice

Pinellia tuber

  1. Treatment of Dementia-related Symptoms with Japanese Traditional Medicine (Kampo): A Review of Clinical Studies

Polygonum aviculare L.

  1. Phytochemical Studies, Investigation of Anti Alzheimer and Anti-Cancer Potentials of Polygonum
  2. Juglanin ameliorates LPS-induced neuroinflammation in animal models of Parkinson’s disease and cell culture via inactivating TLR4/NF-κB pathway

Polygonum Multiflorum Thumb extract

  1. Long-Term Administration of Polygonum multiflorum Thunb: Reduces Cerebral Ischemia-induced Infarct Volume in Gerbils
  2. Protective effect of Polygonum multiflorum Thunb on amyloid β-peptide 25-35 induced cognitive deficits in mice
  3. Neuroprotective effects of Polygonum multiflorum on nigrostriatal dopaminergic degeneration induced by paraquat and maneb in mice
  4. Polygonum multiflorum Extracts Improve Cognitive Performance in Senescence Accelerated Mice
  5. [Progress of study on brain protective effect and mechanism of Polygonum multiflorum].
  6. Hexane extracts of Polygonum multiflorum improve tissue and functional outcome following focal cerebral ischemia in mice
  7. Effect of Ethanolic Extract from Root Tuber of Polygonum multiflorum Thunb.on Liver and Brain Monoamine Oxidase in Senescence-accelerated Mice in vivo
  8. Experimental Study on Effection of Cerebral Cell’s Expression of Bcl-2 Gene by Polygonum Multiflorum Thunb
  9. Beneficial Effects of Polygonum multiflorum on Hippocampal Neuronal Cells and Mouse Focal Cerebral Ischemia
  10. Neuroprotective effects of Polygonum multiflorum extract against glutamate-induced oxidative toxicity in HT22 hippocampal cells


  1. Maternal Dietary Supplementation with Pomegranate Juice Is Neuroprotective in an Animal Model of Neonatal Hypoxic-Ischemic Brain Injury
  2. Pomegranate Polyphenols and Resveratrol Protect the Neonatal Brain against Hypoxic-Ischemic Injury
  3. Antioxidant activities of Punica granatum (pomegranate) peel extract on brain of rats
  4. Evaluating the Potential Role of Pomegranate Peel in Aluminum-Induced Oxidative Stress and Histopathological Alterations in Brain of Female Rats
  5. Pomegranate extract protects against cerebral ischemia/reperfusion injury and preserves brain DNA integrity in rats
  6. Pomegranate from Oman Alleviates the Brain Oxidative Damage in Transgenic Mouse Model of Alzheimer’s Disease
  7. Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer’s disease
  8. Effects of Pomegranate Seed Oil on Lipoperoxidation and Activity of Antioxidant Enzymes in Liver and Brain of Rats
  9. Anti‐depressive effect of polyphenols and omega‐3 fatty acid from pomegranate peel and flax seed in mice exposed to chronic mild stress
  10. Improving Active and Passive Avoidance Memories Deficits Due to Permanent Cerebral Ischemia by Pomegranate Seed Extract in Female Rats


  1. Effects of pterostilbene and resveratrol on brain and behavior
  2. Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer’s disease
  3. Pterostilbene Attenuates Early Brain Injury Following Subarachnoid Hemorrhage via Inhibition of the NLRP3 Inflammasome and Nox2-Related Oxidative Stress
  4. Orally administrated pterostilbene attenuates acute cerebral ischemia–reperfusion injury in a dose- and time-dependent manner in mice
  5. HO-1 Signaling Activation by Pterostilbene Treatment Attenuates Mitochondrial Oxidative Damage Induced by Cerebral Ischemia Reperfusion Injury
  6. Neuroprotective effects of pterostilbene against oxidative stress injury: Involvement of nuclear factor erythroid 2-related factor 2 pathway
  7. Neuroprotective actions of pterostilbene on hypoxic-ischemic brain damage in neonatal rats through upregulation of heme oxygenase-1
  8. Method to Ameliorate Oxidative Stress and Improve Working Memory Via Pterostilbene Administration
  9. Pterostilbene ameliorates intracerebroventricular streptozotocin induced memory decline in rats
  10. Pterostilbene attenuates lipopolysaccharide-induced learning and memory impairment possibly via inhibiting microglia activation and protecting neuronal injury in mice

Puerarin extract

  1. Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats
  2. Puerarin protects against ischemic brain injury in a rat model of transient focal ischemia
  3. Effects of puerarin on D-galactose-induced memory deficits in mice.
  4. Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition
  5. Puerarin Acts Through Brain Serotonergic Mechanisms to Induce Thermal Effects
  6. The Permeability of Puerarin Loaded Poly(butylcyanoacrylate) Nanoparticles Coated with Polysorbate 80 on the Blood–Brain Barrier and Its Protective Effect against Cerebral Ischemia/Reperfusion Injury
  7. Puerarin ameliorates oxidative stress in a rodent model of traumatic brain injury
  8. Effects of Puerarin on LearningMemory and Amino Acid Transmitters of Brain in Ovariectomized Mice
  9. HP-β-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia–reperfusion injury in rats
  10. Pharmacokinetic interaction between puerarin and edaravone, and effect of borneol on the brain distribution kinetics of puerarin in rats

Punica granatum seeds extract

  1. Protective effects of Punica granatum seeds extract against aging and scopolamine induced cognitive impairments in mice
  2. Assessment on antioxidant activity of pomegranate seed oil in vivo
  3. Influence of Punica granatum L. on region specific responses in rat brain during Alloxan-Induced diabetes
  4. Punica granatum Protects Against Oxidative Stress in PC12 Cells and Oxidative Stress-Induced Alzheimer’s Symptoms in Mice
  5. Effect of pomegranate (Punica granatum) juice intake on hepatic oxidative stress
  6. Central nervous system activity of acute administration of ethanol extract of Punica granatum L. seeds in mice
  7. Effect of Punica granatum peel extract on learning and memory in rats
  8. Pomegranate (Punica granatum L.) flower improves learning and memory performances impaired by diabetes mellitus in rats
  9. Neuroprotective action of Gmelina arborea (bark)and Punica granatum(peel) extracts
  10. Pomegranate seed hydroalcoholic extract improves memory deficits in ovariectomized rats with permanent cerebral hypoperfusion /ischemia

Purple sweet potato anthocyanin

  1. Purple sweet potato color attenuates oxidative stress and inflammatory response induced by d-galactose in mouse liver
  2. Purple potato (Solanum tuberosum L.) anthocyanins attenuate alcohol-induced hepatic injury by enhancing antioxidant defense
  3. An analytical pipeline to compare and characterise the anthocyanin antioxidant activities of purple sweet potato cultivars
  4. Composition and Stability of Anthocyanins from Purple Solanum tuberosum and Their Protective Influence on Cr(VI) Targeted to Bovine Serum Albumin
  7. Effect of Extrusion on the Antioxidant Capacity and Color Attributes of Expanded Extrudates Prepared from Purple Potato and Yellow Pea Flour Mixes
  8. Thermal Degradation of Anthocyanins from Purple Potato (Cv. Purple Majesty) and Impact on Antioxidant Capacity
  10. The Protective Effects of Anthocyanin-rich Potato Meals Against the Adverse Effects of Polychlorinated Biphenyls (PCBs) in the Human Simulated Gut Digestion


  1. Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance
  2. Myricetin and quercetin, the flavonoid constituents ofGinkgo biloba extract, greatly reduce oxidative metabolism in both resting and Ca2+-loaded brain neurons
  3. Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin
  4. Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats
  5. Quercetin reverses d-galactose induced neurotoxicity in mouse brain
  6. Influence of the antioxidant quercetin in vivo on the level of nitric oxide determined by electron paramagnetic resonance in rat brain during global ischemia and reperfusion
  7. Quercetin activates AMP‐activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol‐induced neurotoxicity
  8. Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer’s disease
  9. Formulation development and systematic optimization of solid lipid nanoparticles of quercetin for improved brain delivery
  10. Nanoencapsulation of quercetin enhances its dietary efficacy in combating arsenic-induced oxidative damage in liver and brain of rats

Radix Polygalae

  1. Effects of tenuifolin extracted from radix polygalae on learning and memory: A behavioral and biochemical study on aged and amnesic mice
  2. Polygalae radix inhibits toxin-induced neuronal death in the Parkinson’s disease models
  3. Onjisaponin B Derived from Radix Polygalae Enhances Autophagy and Accelerates the Degradation of Mutant α-Synuclein and Huntingtin in PC-12 Cells
  4. Experimental Study of the Compatibility of Radix Polygalae and Rhizoma Acori Talarinowii on Anti-Free Radical Damage of the Brain in Rats with Alzheimer’s Disease
  5. Preclinical Evidence of Rapid-Onset Antidepressant-Like Effect in Radix Polygalae Extract
  6. peptide secretion is reduced by Radix Polygalae‑induced autophagy via activation of the AMPK/mTOR pathway
  7. Anti-acetylcholinesterase activities of traditional Chinese medicine for treating Alzheimer’s disease
  8. Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments
  9. In Vivo Effects of Radix Polygalae on Learning,Memory and the Hippocampal Long-Term Potentiation in AD Model Rats
  10. Experimental Research Review on Treatment of Alzheimer’s Disease by Radix Polygalae and Rhizoma Acori Talarinowii


  1. Effect of Resveratrol on Antioxidant Enzyme Activities in the Brain of Healthy Rat
  2. Effects of resveratrol on the rat brain respiratory chain.
  3. Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1–uncoupling protein 2 pathway
  4. Brain protection by resveratrol and fenofibrate against stroke requires peroxisome proliferator-activated receptor α in mice
  5. Resveratrol Mimics Ischemic Preconditioning in the Brain
  6. Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans-resveratrol in rats
  7. Neuroprotection by resveratrol against traumatic brain injury in rats
  8. Neuroprotective effects of resveratrol against traumatic brain injury in immature rats
  9. Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats
  10. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation

Rosa damascena

  1. Pharmacological Effects of Rosa Damascena
  2. Rose oil (from Rosa × damascena Mill.) vapor attenuates depression-induced oxidative toxicity in rat brain
  3. Protection against brain tissues oxidative damage as a possible mechanism for the beneficial effects of Rosa damascena hydroalcoholic extract on scopolamine induced memory impairment in rats
  4. Protective Effects of Rosa damascena and Its Active Constituent on Aβ(25–35)-Induced Neuritic Atrophy
  5. The effect of Rosa damascena essential oil on the amygdala electrical kindling seizures in rat.
  6. Neuroprotective effects of Rosa damascena extract on learning and memory in a rat model of amyloid-β-induced Alzheimer’s disease
  7. Antioxidant and hepatoprotective action of the crude ethanolic extract of the flowering top of Rosa damascena
  8. Novel effects of Rosa damascena extract on memory and neurogenesis in a rat model of Alzheimer’s disease
  9. Anticonvulsant and neuroprotective effects of Rosa damascena hydro-alcoholic extract on rat hippocampus
  10. Rosa damascena oil improves SSRI-induced sexual dysfunction in male patients suffering from major depressive disorders: results from a double-blind, randomized, and placebo-controlled clinical trial

Rosmarinic acid

  1. Rosmarinic acid and caffeic acid produce antidepressive-like effect in the forced swimming test in mice
  2. A natural scavenger of peroxynitrites, rosmarinic acid, protects against impairment of memory induced by Aβ25–35
  3. Neurobehavioral and genotoxic aspects of rosmarinic acid
  4. The Spice Sage and Its Active Ingredient Rosmarinic Acid Protect PC12 Cells from Amyloid-β Peptide-Induced Neurotoxicity
  5. Rosmarinic acid prevents lipid peroxidation and increase in acetylcholinesterase activity in brain of streptozotocin‐induced diabetic rats
  6. Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death
  7. Rosmarinic Acid from Perillae Herba Produces an Antidepressant-Like Effect in Mice through Cell Proliferation in the Hippocampus
  8. Subchronic administration of rosmarinic acid, a natural prolyl oligopeptidase inhibitor, enhances cognitive performances
  9. Rosmarinic acid and caffeic acid reduce the defensive freezing behavior of mice exposed to conditioned fear stress
  10. Rosmarinic acid mediated neuroprotective effects against H2O2-induced neuronal cell damage in N2A cells

Rosmarinus officinalis L

  1. Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain
  2. Protective effect of supercritical fluid rosemary extract, Rosmarinus officinalis, on antioxidants of major organs of aged rats
  3. Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials
  4. Rosmarinus officinalis polyphenols produce anti-depressant like effect through monoaminergic and cholinergic functions modulation
  5. Phenolic compounds from Rosemary (Rosmarinus officinalis L.) attenuate oxidative stress and reduce blood cholesterol concentrations in diet-induced hypercholesterolemic rats
  6. Neuroprotective Effect of Rosmarinus officinalis Extract on Human Dopaminergic Cell line, SH-SY5Y
  7. Carnosol, a component of rosemary (Rosmarinus officinalis L.) protects nigral dopaminergic neuronal cells
  8. Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: Evidence for the involvement of the dopaminergic system
  9. The Therapeutic Potential of Rosemary (Rosmarinus officinalis) Diterpenes for Alzheimer’s Disease
  10. Rosmarinus officinalis L. hydroalcoholic extract, similar to fluoxetine, reverses depressive-like behavior without altering learning deficit in olfactory bulbectomized mice

Rubia cordifolia Linn root extract

  2. Herbal Medicines for the Prevention and Treatment of Alzheimer’s Disease
  3. Antihyperglycemic, antistress and nootropic activity of roots of Rubia cordifolia Linn
  4. Anticonvulsant and behavioral actions of triterpene isolated from Rubia cordifolia Linn.
  5. Rubia cordifolia: a review
  6. Neuroprotective Studies of Rubia cordifolia Linn. on β-amyloid Induced Cognitive Dysfunction in Mice
  7. A review on Rubia cordifolia: Its phyto constituents and therapeutic uses
  8. Screening of selected Indian medicinal plants for acetylcholinesterase inhibitory activity
  10. Traditional and modern use of indian madder (Rubia cordifolia L.): an overview


  1. Comparative study of quercetin and its two glycoside derivatives quercitrin and rutin against methylmercury (MeHg)-induced ROS production in rat brain slices
  2. Rutin protects the neural damage induced by transient focal ischemia in rats
  3. Rutin improves spatial memory in Alzheimer’s disease transgenic mice by reducing oligomer level and attenuating oxidative stress and neuroinflammation
  4. Effects of rutin supplementation on antioxidant status and iron, copper, and zinc contents in mouse liver and brain
  5. Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type
  6. Influence of long-term administration of rutin on spatial memory as well as the concentration of brain neurotransmitters in aged rats
  7. Anticonvulsive effects of intracerebroventricular administration of rutin in rats
  8. Rutin-encapsulated chitosan nanoparticles targeted to the brain in the treatment of Cerebral Ischemia
  9. Rutin Protects Dopaminergic Neurons from Oxidative Stress in an Animal Model of Parkinson’s Disease
  10. Rutin protects against cognitive deficits and brain damage in rats with chronic cerebral hypoperfusion

Salvia officinalis extract

  1. Constituents of Sage (Salvia officinalis) with in vitro Affinity to Human Brain Benzodiazepine Receptor
  2. Antioxidant and Inhibitory Effects of Aqueous Extracts of Salvia officinalis Leaves on Pro-Oxidant-Induced Lipid Peroxidation in Brain and Liver In Vitro
  3. Effects of Salvia officinalis L. (sage) leaves on memory retention and its interaction with the cholinergic system in rats
  4. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: a double blind, randomized and placebo‐controlled trial
  5. Effects of Cholinesterase Inhibiting Sage (Salvia officinalis) on Mood, Anxiety and Performance on a Psychological Stressor Battery
  6. Oxidative Stress in Brains of Male Rats Intoxicated With Aluminum and the Neuromodulating Effect of Some Forms of Sage (Salvia officinalis)
  7. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial
  8. An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers
  9. Differential effects of the aromas of Salvia species on memory and mood
  10. Preventive effects of Salvia officinalis L. against learning and memory deficit induced by diabetes in rats: Possible hypoglycaemic and antioxidant mechanisms

Sambucus ebulus L. flower

  1. Oxidative damage induced by retching; antiemetic and neuroprotective role of Sambucus ebulus L.
  2. The chemistry, pharmacology and clinical properties of Sambucus ebulus: A review
  3. Biological Effects and Clinical Applications of Dwarf Elder (Sambucus ebulus L): A Review
  4. Sambucus ebulus – from traditional medicine to recent studies
  5. Danewort health benefits (Sambucus ebulus Fam. Caprifoliaceae)
  6. Ebulin from Dwarf Elder (Sambucus ebulus L.): A Mini-Review
  7. Sambucus Ebulus (Dwarf Elder) – Facts, Medicinal Uses, Benefits, Side Effects
  8. Sambucus ebulus elburensis fruits: A good source for antioxidants
  9. The study of plant Sambucus Ebulus l. (Caprifoliaceae) from spontaneous flora- and its benefic obtained effects
  10. Antioxidant activities of methanol extract of Sambucus ebulus L. flower

Saururus chinensis

  1. ESP-102, a standardized combined extract of Angelica gigas, Saururus chinensis and Schizandra chinensis, significantly improved scopolamine-induced memory impairment in mice
  2. Aristolactam BII of Saururus chinensis Attenuates Glutamate-Induced Neurotoxicity in Rat Cortical Cultures Probably by Inhibiting Nitric Oxide Production
  3. Neuroprotective phenolics in medicinal plants
  4. Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice
  5. Sauchinone reduces oxygen-glucose deprivation-evoked neuronal cell death via suppression of intracellular radical production
  6. ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue
  7. The effect of idesolide on hippocampus‐dependent recognition memory
  8. Saururus chinensis (Lour.) Baill blocks enterovirus 71 infection by hijacking MEK1–ERK signaling pathway
  9. The effect of Saururus chinensis Baill against oxidative damage and inflammation
  10. Saururus chinensis extract for prevention and treatment of neurodegenerative disease

Sceletium tortuosum (Zembrin)

  1. Acute Effects of Sceletium tortuosum (Zembrin), a Dual 5-HT Reuptake and PDE4 Inhibitor, in the Human Amygdala and its Connection to the Hypothalamus
  2. Proof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary Extract Sceletium tortuosum (Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer’s Dementia
  3. Sceletium tortuosum and Mesembrine: A Potential Alternative Treatment for Depression
  4. Neuro- and immunomodulatory effects of Sceletium tortuosum
  5. Effect of Zembrin® on Brain Electrical Activity in 60 Older Subjects after 6 Weeks of Daily Intake. A Prospective, Randomized, Double-Blind, Placebo-Controlled, 3-Armed Study in a Parallel Design
  6. Exploring Zembrin Extract Derived from South African Plant, Sceletium tortuosum in Targeting cAMP-driven Phosphodiesterase (PDE) Signaling in Alzheimer’s Disease: Synthesis of Evidence
  7. Herbs to curb cyclic nucleotide phosphodiesterase and their potential role in Alzheimer’s disease
  8. Proprietary Extract Sceletium tortuosum (Zembrin®) Targeting Phosphodiesterase-4 (PDE-4) in cognitively healthy subjects: implications for Alzheimer’s
  9. Multi-Target-Directed Ligands Affecting Serotonergic Neurotransmission for Alzheimer’s Disease Therapy: Advances in Chemical and Biological Research
  10. The role of CREB signaling in Alzheimer’s disease and other cognitive disorders

Schizandra chinensis

  1. Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate‐induced toxicity
  2. UFLC–MS/MS method for simultaneous determination of six lignans of Schisandra chinensis (Turcz.) Baill. in normal and insomniac rats brain microdialysates and homogenate samples: towards an in‐depth study for its sedative‐hypnotic activity
  3. Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice
  4. Schisandra chinensis reverses visceral hypersensitivity in a neonatal–maternal separated rat model
  5. Schisandrin B protects against tert-butylhydroperoxide induced cerebral toxicity by enhancing glutathione antioxidant status in mouse brain
  6. Deoxyschizandrin Isolated from the Fruits of Schisandra chinensis Ameliorates A β 1 – 42 -induced Memory Impairment in Mice
  7. Lignans from Schisandra chinensis ameliorate cognition deficits and attenuate brain oxidative damage induced by D-galactose in rats
  8. Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague–Dawley rats
  9. Total Lignans of Schisandra chinensis Ameliorates Aβ1-42-Induced Neurodegeneration with Cognitive Impairment in Mice and Primary Mouse Neuronal Cells
  10. Pharmacological studies on the anxiolytic effect of standardized Schisandra lignans extract on restraint-stressed mice

Sciadopitysin (from Taxus chinensis)

  1. Sciadopitysin: active component from Taxus chinensis for anti-Alzheimer’s disease
  2. Sciadopitysin protects osteoblast function via its antioxidant activity in MC3T3-E1 cells
  3. Sciadopitysin alleviates methylglyoxal-mediated glycation in osteoblastic MC3T3-E1 cells by enhancing glyoxalase system and mitochondrial biogenesis
  4. Neuroprotective effects of naturally occurring biflavonoids
  5. Cognitive Enhancers (Nootropics). Part 3: Drugs Interacting with Targets other than Receptors or Enzymes. Disease-Modifying Drugs. Update 2014
  6. Pharmacogenomics of Alzheimer’s Disease: Novel Therapeutic Strategies for Drug Development
  7. Novel Therapeutic Strategies for Dementia
  8. Studies on the Structure of Sciadopitysin, a Flavonoid from the Leaves of Sciadopitys verticillata SIEB. ET ZUCC. VII.
  9. Sciadopitysin suppresses RANKL-mediated osteoclastogenesis and prevents bone loss in LPS-treated mice
  10. Studies on the Structure of Sciadopitysin, a Flavonoid from the Leaves of Sciadopitys verticillata SIEB. ET ZUCC.

Scutellaria baicalensis Georgi

  1. Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia
  2. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi
  3. Protective effect of flavonoids from Scutellaria baicalensis Georgi on cerebral ischemia injury
  4. Effects of Amelioration of Total Flavonoids from Stems and Leaves of Scutellaria baicalensis Georgi on Cognitive Deficits, Neuronal Damage and Free Radicals Disorder Induced by Cerebral Ischemia in Rats
  5. Memory improvement in ibotenic acid induced model rats by extracts of Scutellaria baicalensis
  6. Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion-induced memory impairments and chronic lipopolysaccharide infusion-induced memory impairments
  7. Flavones from Root of Scutellaria Baicalensis Georgi: Drugs of the Future in Neurodegeneration?
  8. Potent Inhibitory Effect of Flavonoids in Scutellaria baicalensis on Amyloid β Protein-Induced Neurotoxicity
  9. Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice
  10. Extract from Scutellaria baicalensis Georgi Attenuates Oxidant Stress in Cardiomyocytes


  1. Improvement of brain energy metabolism and cholinergic functions contributes to the beneficial effects of silibinin against streptozotocin induced memory impairment
  2. Neuroprotective effect of silibinin in diabetic mice
  3. Protection by silibinin against experimental ischemic stroke: Up-regulated pAkt, pmTOR, HIF-1α and Bcl-2, down-regulated Bax, NF-κB expression
  4. Silibinin prevents amyloid β peptide‐induced memory impairment and oxidative stress in mice
  5. Response of brain metastasis from lung cancer patients to an oral nutraceutical product containing silibinin
  6. Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment
  7. Silibinin inhibits acetylcholinesterase activity and amyloid β peptide aggregation: a dual-target drug for the treatment of Alzheimer’s disease
  8. Silibinin prevents dopaminergic neuronal loss in a mouse model of Parkinson’s disease via mitochondrial stabilization
  9. Silibinin Attenuates MPP+-Induced Neurotoxicity in the Substantia Nigra In Vivo
  10. Hesperidin and Silibinin Ameliorate Aluminum-Induced Neurotoxicity: Modulation of Antioxidants and Inflammatory Cytokines Level in Mice Hippocampus

Spirulina 65% platensis protean extract and the biliprotein phycocyanin isolated from this microalga

  1. Dietary supplementation with blueberries, spinach, or spirulina reduces ischemic brain damage
  2. Protective effect of Spirulina on lead induced deleterious changes in the lipid peroxidation and endogenous antioxidants in rats
  3. Spirulina or dandelion-enriched diet of mothers alleviates lead-induced damages in brain and cerebellum of newborn rats
  4. Spirulina Prevents Memory Dysfunction, Reduces Oxidative Stress Damage and Augments Antioxidant Activity in Senescence-Accelerated Mice
  5. Neuroprotective effect of Spirulina in cerebral ischemia–reperfusion injury in rats
  6. Spirulina and C-phycocyanin reduce cytotoxicity and inflammation-related genes expression of microglial cells
  7. A Spirulina-Enhanced Diet Provides Neuroprotection in an α-Synuclein Model of Parkinson’s Disease
  8. Investigation on the role of Spirulina platensis in ameliorating behavioural changes, thyroid dysfunction and oxidative stress in offspring of pregnant rats exposed to fluoride
  9. Spirulina Promotes Stem Cell Genesis and Protects against LPS Induced Declines in Neural Stem Cell Proliferation
  10. Neuroprotective effect of Spirulina in a mouse model of ALS

Triticum aestivum L.

  1. Three stages of meiotic homologous chromosome pairing in wheat: cognition, alignment and synapsis
  2. The Ph1 and Ph2 loci play different roles in the synaptic behaviour of hexaploid wheat Triticum aestivum
  3. Large-Scale Psychological Differences Within China Explained by Rice Versus Wheat Agriculture
  4. Effects of wheat-flour biscuits fortified with iron and EDTA, alone and in combination, on blood lead concentration, iron status, and cognition in children: a double-blind randomized controlled trial
  5. Dry-fractionation of wheat bran increases the bioaccessibility of phenolic acids in breads made from processed bran fractions
  6. Immune‐stimulating and Gut Health‐promoting Properties of Short‐chain Fructo‐oligosaccharides
  9. Wheat Bran Improves Cognition in Older Adults with Memory Impairment: A Randomized Controlled Trial
  10. Antioxidant activity of durum wheat bran

Uncaria sinensis

  1. Efficacy of Choto-san on vascular dementia and the protective effect of the hooks and stems of Uncaria sinensis on glutamate-induced neuronal death
  2. Evaluation of the Protective Effects of Alkaloids Isolated from the Hooks and Stems of Uncaria sinensis on Glutamate‐induced Neuronal Death in Cultured Cerebellar Granule Cells from Rats
  3. Protective Effect of Phenolic Compounds Isolated from the Hooks and Stems of Uncaria sinensis on Glutamate-Induced Neuronal Death
  4. Effects of Choto-san and hooks and stems of Uncaria sinensis on antioxidant enzyme activities in the gerbil brain after transient forebrain ischemia
  5. Pharmacological studies of geissoschizine methyl ether, isolated from Uncaria sinensis Oliv., in the central nervous system
  6. Anti-Neuroinflammatory Effects of Uncaria sinensis in LPS-Stimulated BV2 Microglia Cells and Focal Cerebral Ischemic Mice
  7. Neuroprotective Effects of a Novel Single Compound 1-Methoxyoctadecan-1-ol Isolated from Uncaria sinensis in Primary Cortical Neurons and a Photothrombotic Ischemia Model
  8. Neuroprotection by methanol extract of Uncaria rhynchophylla against global cerebral ischemia in rats
  9. Hexane extract from Uncaria sinensis exhibits anti-apoptotic properties against glutamate-induced neurotoxicity in primary cultured cortical neurons
  10. Protective activity of the Uncaria tomentosa extracts on human erythrocytes in oxidative stress induced by 2,4-dichlorophenol (2,4-DCP) and catechol

Vaccinium angustifolium wild blueberry extract

  1. Blueberry Supplementation Improves Memory in Older Adults
  2. Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels
  3. Blueberry Supplemented Diet: Effects on Object Recognition Memory and Nuclear Factor-kappa B Levels in Aged Rats
  4. Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats
  5. Short-term blueberry-enriched diet prevents and reverses object recognition memory loss in aging rats
  6. Effects of a single dose of a flavonoid-rich blueberry drink on memory in 8 to 10 y old children
  7. Modulation of Hippocampal Plasticity and Cognitive Behavior by Short-term Blueberry Supplementation in Aged Rats
  8. Cyanidin-3-O-galactoside and Blueberry Extracts Supplementation Improves Spatial Memory and Regulates Hippocampal ERK Expression in Senescence-accelerated Mice
  9. Blueberry Supplementation Improves Memory in Middle-Aged Mice Fed a High-Fat Diet
  10. Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits with Blueberry, Spinach, or Strawberry Dietary Supplementation

Valeriana officinalis

  1. In vitro study on the interaction of Valeriana officinalis L. extracts and their amino acids on GABAA receptor in rat brain
  2. Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis
  3. Transport of a GABAA Receptor Modulator and Its Derivatives from Valeriana officinalis L. s. l. Across an in Vitro Cell Culture Model of the Blood-Brain Barrier
  4. Effects of Valeriana Officinalis Extracts on [3H]Flunitrazepam Binding, Synaptosomal [3H]GABA Uptake, and Hippocampal [3H]GABA Release
  5. Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties
  6. Cytoprotective Effect of Valeriana officinalis Extract on an In Vitro Experimental Model of Parkinson Disease
  7. Valeriana officinalis extract and its main component, valerenic acid, ameliorate d-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation
  8. The effects of Valeriana officinalis L. hydro-alcoholic extract on depression like behavior in ovalbumin sensitized rats
  9. Valeriana officinalis Extracts Ameliorate Neuronal Damage by Suppressing Lipid Peroxidation in the Gerbil Hippocampus Following Transient Cerebral Ischemia

Vitexin (from mung bean extract)

  1. Vitexin protects brain against ischemia/reperfusion injury via modulating mitogen-activated protein kinase and apoptosis signaling in mice
  2. Vitexin reduces hypoxia–ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model
  3. Antioxidant effects of the orientin and vitexin in Trollius chinensis Bunge in D-galactose-aged mice
  4. Neuroprotective Effects of Vitexin, a Flavonoid, on Pentylenetetrazole‐Induced Seizure in Rats
  5. Effects of Vitexin on Scopolamine-Induced Memory Impairment in Rats
  6. Vitexin protects against hypoxic-ischemic injury via inhibiting Ca2+/Calmodulin-dependent protein kinase II and apoptosis signaling in the neonatal mouse brain
  7. Neuroprotective effects of vitexin against isoflurane-induced neurotoxicity by targeting the TRPV1 and NR2B signaling pathways
  8. Improvement of spatial learning and memory, cortical gyrification patterns and brain oxidative stress markers in diabetic rats treated with Ficus deltoidea leaf extract and vitexin
  9. Vitexin induces G2/M‑phase arrest and apoptosis via Akt/mTOR signaling pathway in human glioblastoma cells
  10. Vitexin reduces epilepsy after hypoxic ischemia in the neonatal brain via inhibition of NKCC1

Walnut extract

  1. Protective Effects of Walnut Extract Against Amyloid Beta Peptide-Induced Cell Death and Oxidative Stress in PC12 Cells
  2. Walnut extract (Juglans regia L.) and its component ellagic acid exhibit anti-inflammatory activity in human aorta endothelial cells and osteoblastic activity in the cell line KS483
  3. Role of Walnuts in Maintaining Brain Health with Age
  4. Tissue concentrations of 4-HNE in the black walnut extract model of laminitis: Indication of oxidant stress in affected laminae
  5. The beneficial effects of tree nuts on the aging brain
  6. The Anticonvulsant and Neuroprotective Effects of Walnuts on the Neurons of Rat Brain Cortex
  7. Neuroprotective Effect of Natural Products Against Alzheimer’s Disease
  8. Walnut consumption protects rats against cisplatin-induced neurotoxicity
  9. Protective Effect of Juglans regia L. Walnut Extract Against Oxidative DNA Damage
  10. Dietary Supplementation of Walnuts Improves Memory Deficits and Learning Skills in Transgenic Mouse Model of Alzheimer’s Disease

Withania somnifera roots

  1. Systemic administration of defined extracts from Withania somnifera (Indian ginseng) and Shilajit differentially affects cholinergic but not glutamatergic and GABAergic markers in rat brain
  2. Susceptibility of hippocampus and cerebral cortex to oxidative damage in streptozotocin treated mice: prevention by extracts of Withania somnifera and Aloe vera
  3. Evaluation of Withania somnifera in a middle cerebral artery occlusion model of stroke in rats
  4. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study
  5. Withania somnifera reverses Alzheimer’s disease pathology by enhancing low-density lipoprotein receptor-related protein in liver
  6. Neuroprotective Effects of Withania somnifera Dunn. in Hippocampal Sub‐regions of Female Albino Rat
  7. Neuroprotective effects of Withania somnifera on 6-hydroxydopamine induced Parkinsonism in rats
  8. The neuroprotective effect of Withania somnifera root extract in MPTP-intoxicated mice: An analysis of behavioral and biochemical varibles
  9. Effect of Withania somnifera root extract on reserpine‐induced orofacial dyskinesia and cognitive dysfunction
  10. Possible Neuroprotective Effect of Withania somnifera Root Extract Against 3-Nitropropionic Acid-Induced Behavioral, Biochemical, and Mitochondrial Dysfunction in an Animal Model of Huntington’s Disease

Zingiber officinale Roscoe extract

  1. Alterations in behavior and memory induced by the essential oil of Zingiber officinale Roscoe (ginger) in mice are cholinergic-dependent
  2. In vitro evaluation of anti-Alzheimer effects of dry ginger (Zingiber officinale Roscoe) extract
  3. Protective Effect of Ginger (Zingiber officinale) on Alzheimer’s disease Induced in Rats
  4. Antioxidant and inhibitory effect of red ginger (Zingiber officinale var. Rubra) and white ginger (Zingiber officinale Roscoe) on Fe2+ induced lipid peroxidation in rat brain in vitro
  5. Zingiber officinale Mitigates Brain Damage and Improves Memory Impairment in Focal Cerebral Ischemic Rat
  6. Zingiber officinale Improves Cognitive Function of the Middle-Aged Healthy Women
  7. Ginger improves cognitive function via NGF-induced ERK/CREB activation in the hippocampus of the mouse
  8. 6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia
  9. Inhibitory potential of ginger extracts against enzymes linked to type 2 diabetes, inflammation and induced oxidative stress
  10. Effect of Different Light Intensities on Total Phenolics and Flavonoids Synthesis and Anti-oxidant Activities in Young Ginger Varieties (Zingiber officinale Roscoe)

Zizyphus jujube Extract

  1. Antioxidant effects of solvent extracts from the dried jujube (Zizyphus jujube) sarcocarp, seed, and leaf via sonication
  2. Chapter 87 – Use of Seeds of Malay Apple (Ziziphus mauritiana) and Related Species in Health and Disease
  3. A Review of Dietary Ziziphus jujuba Fruit (Jujube): Developing Health Food Supplements for Brain Protection
  4. Neurophysiological study on possible protective and therapeutic effects of Sidr (Zizyphus spina-christi L.) leaf extract in male albino rats treated with pentylenetetrazol
  5. A review study on medicinal plants used in the treatment of learning and memory impairments
  6. Oxidative stress and genes regulation of cerebral malaria upon Zizyphus spina-christi treatment in a murine model
  7. Chemical and Biological Assessment of Ziziphus jujuba (Jujubes) Fruit from China of Different Geographical Sources and Developmental Stages: Chemical Composition and Possible Targets in Developing Health Food Products
  9. The Antioxidant Effect of Sidr (Zizyphusspina-Christi) Leaf Extract Helping to Improve the Scopolamine Induced Memory Impairment in Male Rats
  10. Protective effects of bioactive phenolics from jujube (Ziziphus jujuba) seeds against H2O2–induced oxidative stress in neuronal PC-12 cells


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