SIRT1

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SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuinhomolog (biological equivalent across species) in yeast (S. cerevisiae) is Sir2. SIRT1 is an enzyme that deacetylates proteins that contribute to cellular regulation (reaction to stressors, longevity).[8]
Sirtuin 1 is a member of the sirtuin family of proteins, homologs of the Sir2 gene in S. cerevisiae. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family.[6] Sirtuin 1 is downregulated in cells that have high insulin resistance and inducing its expression increases insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity.[9]Furthermore, SIRT1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors.[10][11][12][13][14][15] In mammals, SIRT1 has been shown to deacetylate and thereby deactivate the p53 protein.[16] SIRT1 also stimulates autophagy by preventing acetylation of proteins (via deacetylation) required for autophagy as demonstrated in cultured cells and embryonic and neonatal tissues. This function provides a link between sirtuin expression and the cellular response to limited nutrients due to caloric restriction.[17] Furthermore, SIRT1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors.[10][11][12][13][14][15] Human aging is characterized by a chronic, low-grade inflammation level[18] and NF-κB is the main transcriptional regulator of genes related to inflammation.[19] SIRT1 inhibits NF-κB-regulated gene expression by deacetylating the RelA/p65 subunit of NF-κB at lysine 310.[20][21] Increased expression of SIRT1 protein extended both the mean and maximal lifespan of mice.[53] In these mice health was also improved as well as bone and muscle mass. Another SIRT1 activator (SRT1720) also extended lifespan and improved the health of mice.[54]

A Remarkable Age-Related Increase in SIRT1 Protein Expression against Oxidative Stress in Elderly: SIRT1 Gene Variants and Longevity in Human

Aging is defined as the accumulation of progressive organ dysfunction. Controlling the rate of aging by clarifying the complex pathways has a significant clinical importance. Nowadays, sirtuins have become famous molecules for slowing aging and decreasing age-related disorders. In the present study, we analyzed the SIRT1 gene polymorphisms (rs7895833 A>G, rs7069102 C>G and rs2273773 C>T) and its relation with levels of SIRT1, eNOS, PON-1, cholesterol, TAS, TOS, and OSI to demonstrate the association between genetic variation in SIRT1 and phenotype at different ages in humans. We observed a significant increase in the SIRT1 level in older people and found a significant positive correlation between SIRT1 level and age in the overall studied population. The oldest people carrying AG genotypes for rs7895833 have the highest SIRT1 level suggesting an association between rs7895833 SNP and lifespan longevity. Older people have lower PON-1 levels than those of adults and children which may explain the high levels of SIRT1 protein as a compensatory mechanism for oxidative stress in the elderly. The eNOS protein level was significantly decreased in older people as compared to adults. There was no significant difference in the eNOS level between older people and children. The current study is the first to demonstrate age-related changes in SIRT1 levels in humans and it is important for a much better molecular understanding of the role of the longevity gene SIRT1 and its protein product in aging. It is also the first study presenting the association between SIRT1 expression in older people and rs7895833 in SIRT1 gene.
LONGEVITY FORMULA: ✅AMPK ✅Autophagy ✅SIRT1 ✅Insulin Sensitivity XmTOR XOxidative Stress XInflammation
  • ✅=Activate, INCREASE, ENHANCE
  • X=Turn Down, Neutralize, Inhibit
  This is EXACTLY what the blends and fasting achieves.  1000 Scientific Studies
  1. A novel pathway regulates memory and plasticity via SIRT1 and miR-134
  2. Metabolic adaptations through the PGC‐1α and SIRT1 pathways
  3. Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice
  4. SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice
  5. How does SIRT1 affect metabolism, senescence and cancer?
  6. SIRT1 and energy metabolism
  7. Regulation of SIRT1 in cellular functions: Role of polyphenols
  8. SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function
  9. Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
  10. SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging
  11. Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
  12. Mammalian SIRT1 Represses Forkhead Transcription Factors
  13. Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase
  14. Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
  15. miR-34a repression of SIRT1 regulates apoptosis
  16. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
  17. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
  18. Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
  19. Mechanism of Human SIRT1 Activation by Resveratrol
  20. Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
  21. Calorie restriction, SIRT1 and metabolism: understanding longevity
  22. Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration
  23. SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation
  24. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
  25. Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1
  26. Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway
  27. Sirt1 protects against high-fat diet-induced metabolic damage
  28. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
  29. Increase in Activity During Calorie Restriction Requires Sirt1
  30. DBC1 is a negative regulator of SIRT1
  31. SIRT1 transgenic mice show phenotypes resembling calorie restriction
  32. Tissue-specific regulation of SIRT1 by calorie restriction
  33. SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α
  34. The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control
  35. Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart
  36. SIRT1 and other sirtuins in metabolism
  37. Nucleocytoplasmic Shuttling of the NAD+-dependent Histone Deacetylase SIRT1
  38. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
  39. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
  40. PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
  41. SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1
  42. AMPK and SIRT1: a long-standing partnership?
  43. SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR
  44. Caloric restriction, SIRT1 and longevity
  45. Phosphorylation of HuR by Chk2 Regulates SIRT1 Expression
  46. Negative regulation of the deacetylase SIRT1 by DBC1
  47. SIRT1 controls endothelial angiogenic functions during vascular growth
  48. SIRT1 and insulin resistance
  49. Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells
  50. SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B
  51. The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth
  52. Human SirT1 Interacts with Histone H1 and Promotes Formation of Facultative Heterochromatin
  53. SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase
  54. MiR-34, SIRT1, and p53: The feedback loop
  55. SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
  56. PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation
  57. Phosphorylation Regulates SIRT1 Function
  58. Active Regulator of SIRT1 Cooperates with SIRT1 and Facilitates Suppression of p53 Activity
  59. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis
  60. Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1
  61. SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling
  62. Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses
  63. SIRT1 Regulates HIV Transcription via Tat Deacetylation
  64. SIRT1 Is Significantly Elevated in Mouse and Human Prostate Cancer
  65. Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
  66. Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1
  67. Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation
  68. Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle
  69. Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1
  70. SIRT1 and endocrine signaling
  71. Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
  72. SirT1 Regulates Adipose Tissue Inflammation
  73. The interaction between FOXO and SIRT1: tipping the balance towards survival
  74. Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity
  75. SIRT1: recent lessons from mouse models
  76. SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice
  77. Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt
  78. SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation
  79. Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ
  80. SIRT1, Is It a Tumor Promoter or Tumor Suppressor?
  81. SIRT1 promotes DNA repair activity and deacetylation of Ku70
  82. SIRT1 Negatively Regulates the Mammalian Target of Rapamycin
  83. Sirt1 contributes critically to the redox-dependent fate of neural progenitors
  84. Sirt1 modulates premature senescence-like phenotype in human endothelial cells
  85. STAT3 inhibition of gluconeogenesis is downregulated by SirT1
  86. RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10
  87. Shear stress, SIRT1, and vascular homeostasis
  88. Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated Tumorigenesis
  89. The ups and downs of SIRT1
  90. Suppression of FOXO1 activity by FHL2 through SIRT1‐mediated deacetylation
  91. The Critical Role of the Class III Histone Deacetylase SIRT1 in Cancer
  92. Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation
  93. SIRT1 in Neurodevelopment and Brain Senescence
  94. SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes
  95. Neuroprotective role of Sirt1 in mammalian models of Huntington’s disease through activation of multiple Sirt1 targets
  96. Function of the SIRT1 protein deacetylase in cancer
  97. SIRT1 and SIRT2: emerging targets in neurodegeneration
  98. Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation
  99. SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity
  100. JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity
  101. Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1
  102. Protective roles of SIRT1 in atherosclerosis
  103. SIRT1: Regulation of longevity via autophagy
  104. Cancer-Specific Functions of SIRT1 Enable Human Epithelial Cancer Cell Growth and Survival
  105. Cytoplasm‐localized SIRT1 enhances apoptosis
  106. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity
  107. Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability
  108. Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction
  109. Hormonal Control of Androgen Receptor Function through SIRT1
  110. SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1 POSSIBLE ROLE IN AMP-ACTIVATED PROTEIN KINASE ACTIVATION
  111. Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase
  112. SIRT1 Regulates the Function of the Nijmegen Breakage Syndrome Protein
  113. SIRT1 and p53, effect on cancer, senescence and beyond
  114. SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism
  115. Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease
  116. Small molecule SIRT1 activators for the treatment of aging and age-related diseases
  117. SIRT1 Regulates Adiponectin Gene Expression through Foxo1-C/Enhancer-binding Protein α Transcriptional Complex
  118. Exercise Training Promotes SIRT1 Activity in Aged Rats
  119. SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
  120. Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats
  121. Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation
  122. SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2
  123. SIRT1 regulation of apoptosis of human chondrocytes
  124. Age‐associated loss of Sirt1‐mediated enhancement of glucose‐stimulated insulin secretion in beta cell‐specific Sirt1‐overexpressing (BESTO) mice
  125. SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress
  126. Progressive loss of SIRT1 with cell cycle withdrawal
  127. MicroRNA regulation of SIRT1
  128. SIRT1, an Antiinflammatory and Antiaging Protein, Is Decreased in Lungs of Patients with Chronic Obstructive Pulmonary Disease
  129. Adiponectin Secretion Is Regulated by SIRT1 and the Endoplasmic Reticulum Oxidoreductase Ero1-Lα
  130. Biochemical effects of SIRT1 activators
  131. Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
  132. Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras–MAPK signaling in human cancer cells
  133. Mammalian Sirt1: insights on its biological functions
  134. Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage
  135. Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1
  136. Sirt1 activation protects the mouse renal medulla from oxidative injury
  137. Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
  138. Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes
  139. Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway
  140. Deacetylation of cortactin by SIRT1 promotes cell migration
  141. SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging
  142. Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands
  143. Metabolic benefits from Sirt1 and Sirt1 activators
  144. Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice
  145. SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons
  146. Strong expression of a longevity-related protein, SIRT1, in Bowen’s disease
  147. Negative regulation of inflammation by SIRT1
  148. Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway
  149. Protective Role of SIRT1 in Diabetic Vascular Dysfunction
  150. SIRT1 and neuronal diseases
  151. A c-Myc–SIRT1 feedback loop regulates cell growth and transformation
  152. SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence
  153. JNK2-dependent regulation of SIRT1 protein stability
  154. SIRT1 Regulates Apoptosis and Nanog Expression in Mouse Embryonic Stem Cells by Controlling p53 Subcellular Localization
  155. Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders
  156. Regulation of MEF2 by Histone Deacetylase 4- and SIRT1 Deacetylase-Mediated Lysine Modifications
  157. Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress
  158. Emerging roles of SIRT1 in vascular endothelial homeostasis
  159. PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure
  160. Activation of Sirt1 Decreases Adipocyte Formation During Osteoblast Differentiation of Mesenchymal Stem Cells
  161. Redox regulation of SIRT1 in inflammation and cellular senescence
  162. SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA
  163. SIRT1 contributes to telomere maintenance and augments global homologous recombination
  164. Metformin suppresses hepatic gluconeogenesis through inductionof SIRT1 and GCN5
  165. Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction
  166. Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib
  167. Sirt1: a metabolic master switch that modulates lifespan
  168. Dietary activators of Sirt1
  169. SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones
  170. Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress
  171. sirt1-null mice develop an autoimmune-like condition
  172. SIRT1: Tumor promoter or tumor suppressor?
  173. SIRT1 Deacetylation and Repression of p300 Involves Lysine Residues 1020/1024 within the Cell Cycle Regulatory Domain 1
  174. FoxO1 Mediates an Autofeedback Loop Regulating SIRT1 Expression
  175. A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9
  176. SIRT1 Activation Confers Neuroprotection in Experimental Optic Neuritis
  177. The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
  178. Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex
  179. Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
  180. Expression of DBC1 and SIRT1 Is Associated with Poor Prognosis of Gastric Carcinoma
  181. Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System
  182. SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential
  183. Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor-κB Signaling Pathway
  184. Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
  185. Sirtuin 1 (SIRT1): The Misunderstood HDAC
  186. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
  187. Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1‐dependent adenosine monophosphate–activated kinase pathway
  188. Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells
  189. Janus-faced role of SIRT1 in tumorigenesis
  190. SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis
  191. High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction
  192. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
  193. DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1
  194. SIRT1 Inhibits Transforming Growth Factor β-Induced Apoptosis in Glomerular Mesangial Cells via Smad7 Deacetylation
  195. Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats
  196. A Review of Sirt1 and Sirt1 Modulators in Cardiovascular and Metabolic Diseases
  197. SIRT1-mediated acute cardioprotection
  198. Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process
  199. SIRT1: roles in aging and cancer
  200. The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet
  201. Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH
  202. SIRT1 Is a Circadian Deacetylase for Core Clock Components
  203. Regulation of SIRT1 protein levels by nutrient availability
  204. SIRT1 deacetylates APE1 and regulates cellular base excision repair
  205. MicroRNA 132 Regulates Nutritional Stress-Induced Chemokine Production through Repression of SirT1
  206. Resveratrol Protects Human Endothelium from H2O2-Induced Oxidative Stress and Senescence via SirT1 Activation
  207. Enzymes in the NAD+ Salvage Pathway Regulate SIRT1 Activity at Target Gene Promoters
  208. Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1
  209. Activation of Sirt1 by Resveratrol Inhibits TNF-α Induced Inflammation in Fibroblasts
  210. Induction of Manganese Superoxide Dismutase by Nuclear Translocation and Activation of SIRT1 Promotes Cell Survival in Chronic Heart Failure
  211. Sirt1 and the Mitochondria
  212. Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
  213. High glucose downregulates endothelial progenitor cell number via SIRT1
  214. Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1–FoxO1 pathway
  215. NAD+-dependent SIRT1 Deacetylase Participates in Epigenetic Reprogramming during Endotoxin Tolerance
  216. SIRT1, metabolism and cancer
  217. FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States
  218. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
  219. SIRT1 Promotes Cell Survival under Stress by Deacetylation-Dependent Deactivation of Poly(ADP-Ribose) Polymerase 1
  220. Resveratrol inhibits insulin responses in a SirT1-independent pathway
  221. SIRT1 interacts with p73 and suppresses p73‐dependent transcriptional activity
  222. miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues
  223. SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice
  224. SirT1 Is an Inhibitor of Proliferation and Tumor Formation in Colon Cancer
  225. SIRT1 Promotes Differentiation of Normal Human Keratinocytes
  226. Sirt1 activation by resveratrol is substrate sequence-selective
  227. Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
  228. A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development
  229. Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner
  230. miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells
  231. SIRT1 Deacetylase in SF1 Neurons Protects against Metabolic Imbalance
  232. Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy
  233. SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress
  234. Repression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction
  235. The Roles of SIRT1 in Cancer
  236. The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice
  237. Sirt1 increases skeletal muscle precursor cell proliferation
  238. Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island
  239. NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease
  240. Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
  241. SIRT1 Suppresses Activator Protein-1 Transcriptional Activity and Cyclooxygenase-2 Expression in Macrophages
  242. MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1
  243. SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin
  244. SIRT1 stimulation by polyphenols is affected by their stability and metabolism
  245. Control of Multidrug Resistance Gene mdr1 and Cancer Resistance to Chemotherapy by the Longevity Gene sirt1
  246. SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis
  247. Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes
  248. Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway
  249. Cilostazol Inhibits Oxidative Stress–Induced Premature Senescence Via Upregulation of Sirt1 in Human Endothelial Cells
  250. Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues
  251. MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression
  252. The Direct Involvement of SirT1 in Insulin-induced Insulin Receptor Substrate-2 Tyrosine Phosphorylation
  253. Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma
  254. Regulation of Cartilage-specific Gene Expression in Human Chondrocytes by SirT1 and Nicotinamide Phosphoribosyltransferase
  255. SIRT1 Activation by Small Molecules KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR
  256. The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+
  257. MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1
  258. Cellular Regulation of SIRT1
  259. SIRT1: Regulator of p53 Deacetylation
  260. SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts
  261. SIRT1 Shows No Substrate Specificity in Vitro
  262. A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells
  263. Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation
  264. The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy
  265. SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity
  266. SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions
  267. MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells
  268. SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL
  269. AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells
  270. Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes
  271. Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
  272. SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression in Vascular Smooth Muscle Cells
  273. Sirt1 Deficiency Attenuates Spermatogenesis and Germ Cell Function
  274. The ways and means that fine tune Sirt1 activity
  275. SIRT1 and insulin resistance
  276. Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression
  277. Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity
  278. Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
  279. SIRT1 Regulates Autoacetylation and Histone Acetyltransferase Activity of TIP60
  280. The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells
  281. Restriction of Advanced Glycation End Products Improves Insulin Resistance in Human Type 2 Diabetes
  282. Resveratrol and Neurodegenerative Diseases: Activation of SIRT1 as the Potential Pathway towards Neuroprotection
  283. SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats
  284. SIRT1 Modulating Compounds from High-Throughput Screening as Anti-Inflammatory and Insulin-Sensitizing Agents
  285. Control of AIF-mediated Cell Death by the Functional Interplay of SIRT1 and PARP-1 in Response to DNA Damage
  286. Inhibition of transcriptional activity of c-JUN by SIRT1
  287. SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol
  288. Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria POSSIBLE DIRECT FUNCTION IN MITOCHONDRIAL BIOGENESIS
  289. Role of SIRT1 in homologous recombination
  290. Metformin modulates hyperglycaemia‐induced endothelial senescence and apoptosis through SIRT1
  291. Expression and prognostic significance of SIRT1 in ovarian epithelial tumours
  292. Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity
  293. Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype
  294. CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability
  295. Regulation of WRN Protein Cellular Localization and Enzymatic Activities by SIRT1-mediated Deacetylation
  296. Sirt1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation
  297. SIRT1 Expression is Associated With Poor Prognosis of Diffuse Large B-Cell Lymphoma
  298. Structural and Functional Analysis of Human SIRT1
  299. SIRT1 Deacetylates the DNA Methyltransferase 1 (DNMT1) Protein and Alters Its Activities
  300. Induction of apoptosis by inhibition of sirtuin SIRT1 expression
  301. SIRT1 Genetic Variation Is Related to BMI and Risk of Obesity
  302. SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons
  303. Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1
  304. Resveratrol and novel potent activators of Sirt1: effects on aging and age-related diseases
  305. SIRT1/eNOS Axis as a Potential Target against Vascular Senescence, Dysfunction and Atherosclerosis
  306. SIRT1 longevity factor suppresses NF‐κB ‐driven immune responses: regulation of aging via NF‐κB acetylation?
  307. Sirt1 protects the heart from aging and stress
  308. Kidney-specific Overexpression of Sirt1 Protects against Acute Kidney Injury by Retaining Peroxisome Function
  309. miR-195 regulates SIRT1-mediated changes in diabetic retinopathy
  310. Nicotinamide Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically Compromised Neurons
  311. SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive
  312. Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53
  313. SIRT1 Positively Regulates Autophagy and Mitochondria Function in Embryonic Stem Cells Under Oxidative Stress
  314. Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis
  315. SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
  316. Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor γ coactivator-1α protein expressions in rat skeletal muscle
  317. Targeting cardiovascular disease with novel SIRT1 pathways
  318. Peptide Switch Is Essential for Sirt1 Deacetylase Activity
  319. The anti-aging, metabolism potential of SIRT1.
  320. SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression
  321. A High-Fat Diet and NAD+ Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome
  322. Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation
  323. Resveratrol Modulates Tumor Cell Proliferation and Protein Translation via SIRT1-Dependent AMPK Activation
  324. Quantitative Acetylome Analysis Reveals the Roles of SIRT1 in Regulating Diverse Substrates and Cellular Pathways
  325. Controlling SIRT1 expression by microRNAs in health and metabolic disease
  326. Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by Sirt1 Protein-mediated Deacetylation
  327. Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 Inhibitors
  328. Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1)
  329. High-intensity interval training increases SIRT1 activity in human skeletal muscle
  330. Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice
  331. Omega-3 Polyunsaturated Fatty Acids Antagonize Macrophage Inflammation via Activation of AMPK/SIRT1 Pathway
  332. Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1α in rats
  333. The NAD World: A New Systemic Regulatory Network for Metabolism and Aging—Sirt1, Systemic NAD Biosynthesis, and Their Importance
  334. SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53
  335. SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease
  336. SIRT1: new avenues of discovery for disorders of oxidative
  337. Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21
  338. Neurogenesis directed by Sirt1
  339. Sirt1 Involvement in rd10 Mouse Retinal Degeneration
  340. SIRT1 metabolic actions: Integrating recent advances from mouse models
  341. SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis
  342. Expression and role of SIRT1 in hepatocellular carcinoma
  343. SIRT1 modulates MAPK pathways in ischemic–reperfused cardiomyocytes
  344. Regulation of SIRT1 activity by genotoxic stress
  345. Sirt1 and mir‐9 expression is regulated during glucose‐stimulated insulin secretion in pancreatic β‐islets
  346. SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model
  347. Association of SIRT1 gene variation with visceral obesity
  348. Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation
  349. SIRT1 mRNA Expression May Be Associated With Energy Expenditure and Insulin Sensitivity
  350. Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2
  351. Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain
  352. TIMP3 Is Reduced in Atherosclerotic Plaques From Subjects With Type 2 Diabetes and Increased by SirT1
  353. SIRT1 Acts as a Modulator of Neointima Formation Following Vascular Injury in Mice
  354. The expression of SIRT1 in nonalcoholic fatty liver disease induced by high‐fat diet in rats
  355. Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice
  356. Sirt1 Activation Ameliorates Renal Fibrosis by Inhibiting the TGF‐β/Smad3 Pathway
  357. Ionizing Radiation Induces Cellular Senescence of Articular Chondrocytes via Negative Regulation of SIRT1 by p38 Kinase
  358. MicroRNA‐146b promotes adipogenesis by suppressing the SIRT1‐FOXO1 cascade
  359. The role of SIRT1 in ocular aging
  360. Chromatin remodeling, metabolism and circadian clocks: The interplay of CLOCK and SIRT1
  361. Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1
  362. Role of Sirtuin Histone Deacetylase SIRT1 in Prostate Cancer
  363. USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development
  364. Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy
  365. Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein
  366. Human Immunodeficiency Virus Type 1 Tat Protein Inhibits the SIRT1 Deacetylase and Induces T Cell Hyperactivation
  367. MST1 Promotes Apoptosis through Regulating Sirt1-dependent p53 Deacetylation
  368. Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression
  369. SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury
  370. SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling
  371. SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity
  372. MicroRNA-217 Promotes Ethanol-induced Fat Accumulation in Hepatocytes by Down-regulating SIRT1
  373. The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals
  374. Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: Implication in pathogenesis of COPD
  375. SIRT1 Promotes the Central Adaptive Response to Diet Restriction through Activation of the Dorsomedial and Lateral Nuclei of the Hypothalamus
  376. Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria
  377. Distinct HIC1-SIRT1-p53 Loop Deregulation in Lung Squamous Carcinoma and Adenocarcinoma Patients
  378. H2O2 Accelerates Cellular Senescence by Accumulation of Acetylated p53 via Decrease in the Function of SIRT1 by NAD+ Depletion
  379. Nicotinamide-induced Mitophagy EVENT MEDIATED BY HIGH NAD+/NADH RATIO AND SIRT1 PROTEIN ACTIVATION
  380. Modulation of SIRT1 expression in different neurodegenerative models and human pathologies
  381. Overexpression of SIRT1 Protein in Neurons Protects against Experimental Autoimmune Encephalomyelitis through Activation of Multiple SIRT1 Targets
  382. SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis
  383. miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
  384. Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway
  385. Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-κB pathways and inhibition of intracellular ROS/RNS generation
  386. Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1
  387. Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol
  388. SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance
  389. Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C
  390. SIRT1: Linking Adaptive Cellular Responses to Aging-Associated Changes in Organismal Physiology
  391. Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1–FOXO1 signaling pathway
  392. MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma
  393. SirT1 fails to affect p53‐mediated biological functions
  394. The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity
  395. SIRT1 deacetylates RORγt and enhances Th17 cell generation
  396. Nutrient-dependent regulation of PGC-1α’s acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5
  397. The controversial links among calorie restriction, SIRT1, and resveratrol
  398. SIRT1 Is Essential for Oncogenic Signaling by Estrogen/Estrogen Receptor α in Breast Cancer
  399. Sirt1 Mediates Hyperbaric Oxygen Preconditioning-Induced Ischemic Tolerance in Rat Brain
  400. Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression
  401. mIGF‐1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart
  402. SIRT1 stabilizes PML promoting its sumoylation
  403. PPARβ/δ regulates the human SIRT1 gene transcription via Sp1
  404. Agrp Neurons Mediate Sirt1‘s Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity
  405. SIRT1, STEM CELLS, AGING, AND STEM CELL AGING
  406. Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice
  407. Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity
  408. Exendin-4 Improves Steatohepatitis by Increasing Sirt1 Expression in High-Fat Diet-Induced Obese C57BL/6J Mice
  409. Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress
  410. Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1α Expression in experimental stroke
  411. Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice
  412. SIRT1 is required for long-term growth of human mesenchymal stem cells
  413. Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/− Mice: A Role of Lipid Mobilization and Inflammation
  414. Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes
  415. Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators
  416. Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity
  417. Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-α production in cultured macrophage cell lines
  418. The SIRT1 activator resveratrol protects SK‐N‐BE cells from oxidative stress and against toxicity caused by α‐synuclein or amyloid‐β (1‐42) peptide
  419. ΔNp63&alpha Overexpression Induces Downregulation of Sirt1 and an Accelerated Aging Phenotype in the Mouse
  420. Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women
  421. Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice
  422. Activation of Sirt1 Decreases Adipocyte Formation during Osteoblast Differentiation of Mesenchymal Stem Cells
  423. Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3
  424. Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling
  425. Protein deacetylation by SIRT1: An emerging key post-translational modification in metabolic regulation
  426. Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2†
  427. SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
  428. Interaction of aging-associated signaling cascades: Inhibition of NF-κB signaling by longevity factors FoxOs and SIRT1
  429. SIRT1 Is a Novel Regulator of Key Pathways of Human Labor
  430. Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice
  431. SIRT1 in cardiovascular aging
  432. SirT1 Regulation of Antioxidant Genes Is Dependent on the Formation of a FoxO3a/PGC-1α Complex
  433. SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2
  434. SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency
  435. SIRT1 markedly extends replicative lifespan if the NAD+ salvage pathway is enhanced
  436. Resveratrol Inhibits β-Amyloid-Induced Neuronal Apoptosis through Regulation of SIRT1-ROCK1 Signaling Pathway
  437. The physiological roles of Sirt1 in skeletal muscle
  438. Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1
  439. Balance between SIRT1 and DBC1 expression is lost in breast cancer
  440. SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma
  441. CK2 Is the Regulator of SIRT1 Substrate-Binding Affinity, Deacetylase Activity and Cellular Response to DNA-Damage
  442. Human SIRT1: A potential biomarker for tumorigenesis?
  443. Regulation of SIRT1 by MicroRNAs
  444. SIRT1 Contributes in Part to Cisplatin Resistance in Cancer Cells by Altering Mitochondrial Metabolism
  445. Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions
  446. Resveratrol Potentiates Glucose-stimulated Insulin Secretion in INS-1E β-Cells and Human Islets through a SIRT1-dependent Mechanism
  447. A Functional Link Between SIRT1 Deacetylase and NBS1 in DNA Damage Response
  448. PPARα-Sirt1 Complex Mediates Cardiac Hypertrophy and Failure through Suppression of the ERR Transcriptional Pathway
  449. Involvement of the Histone Deacetylase SIRT1 in Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF)-interacting Protein 2-mediated Transcriptional Repression
  450. C/EBPα regulates SIRT1 expression during adipogenesis
  451. Nicotinamide Blocks Proliferation and Induces Apoptosis of Chronic Lymphocytic Leukemia Cells through Activation of the p53/miR-34a/SIRT1 Tumor Suppressor Network
  452. Comparative and pharmacophore model for deacetylase SIRT1
  453. Stimulation of Sirt1-Regulated FoxO Protein Function by the Ligand-Bound Vitamin D Receptor
  454. SIRT1 gene is associated with major depressive disorder in the Japanese population
  455. The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing
  456. The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration
  457. SIRT1 Gene, Age-Related Diseases, and Mortality: The Leiden 85-Plus Study
  458. Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators
  459. Deletion of SIRT1 From Hepatocytes in Mice Disrupts Lipin-1 Signaling and Aggravates Alcoholic Fatty Liver
  460. Sirt1 deacetylates c-Myc and promotes c-Myc/Max association
  461. SIRT1 confers protection against UVB‐ and H2O2‐induced cell death via modulation of p53 and JNK in cultured skin keratinocytes
  462. SIRT1 Inhibition Alleviates Gene Silencing in Fragile X Mental Retardation Syndrome
  463. DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia
  464. Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway
  465. Sirt1: Def-eating senescence?
  466. Sirtuin 1 (SIRT1) Deacetylase Activity Is Not Required for Mitochondrial Biogenesis or Peroxisome Proliferator-activated Receptor-γ Coactivator-1α (PGC-1α) Deacetylation following Endurance Exercise
  467. A SUMOylation-Dependent Pathway Regulates SIRT1 Transcription and Lung Cancer Metastasis
  468. Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights
  469. Roles of SIRT1 in the Acute and Restorative Phases following Induction of Inflammation
  470. Stabilization of Suv39H1 by SirT1 Is Part of Oxidative Stress Response and Ensures Genome Protection
  471. A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates
  472. SIRT1 as a therapeutic target in inflammaging of the pulmonary disease
  473. Distribution Analysis of Deacetylase SIRT1 in Rodent and Human Nervous Systems
  474. Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling
  475. SIRT1 Acts as a Nutrient-sensitive Growth Suppressor and Its Loss Is Associated with Increased AMPK and Telomerase Activity
  476. Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells
  477. Roles of FoxO1 and Sirt1 in the central regulation of food intake
  478. Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear Sirt1
  479. Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary
  480. Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis
  481. SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: Implications for vascular aging
  482. SIRT1 in the brain—connections with aging-associated disorders and lifespan
  483. Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
  484. Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via Agouti-Related Peptide
  485. Resveratrol protects against hyperglycemia-induced oxidative damage to mitochondria by activating SIRT1 in rat mesangial cells
  486. SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox
  487. Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity
  488. Sirtuin 1 (SIRT1) Protein Degradation in Response to Persistent c-Jun N-terminal Kinase 1 (JNK1) Activation Contributes to Hepatic Steatosis in Obesity
  489. Proatherogenic Abnormalities of Lipid Metabolism in SirT1 Transgenic Mice Are Mediated through Creb Deacetylation
  490. Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes
  491. BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets
  492. Brain Activation of SIRT1: Role in Neuropathology
  493. SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death
  494. MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration
  495. Silibinin Protects Against Isoproterenol-Induced Rat Cardiac Myocyte Injury Through Mitochondrial Pathway After Up-regulation of SIRT1
  496. Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity
  497. SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1β
  498. Function of SIRT1 in physiology
  499. Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice
  500. SIRT1 Regulates Dendritic Development in Hippocampal Neurons
  501. Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression
  502. SIRT1 Is Involved in Glucocorticoid-mediated Control of Uncoupling Protein-3 Gene Transcription
  503. SIRT1 Modulation as a Novel Approach to the Treatment of Diseases of Aging
  504. Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells
  505. Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice
  506. LncRNA HULC triggers autophagy via stabilizing Sirt1 and attenuates the chemosensitivity of HCC cells
  507. Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1
  508. Identification of a Domain within Peroxisome Proliferator-Activated Receptor γ Regulating Expression of a Group of Genes Containing Fibroblast Growth Factor 21 That Are Selectively Repressed by SIRT1 in Adipocytes
  509. Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism
  510. Resveratrol Upregulated SIRT1, FOXO1, and Adiponectin and Downregulated PPARγ1–3 mRNA Expression in Human Visceral Adipocytes
  511. Crystallographic structure of a small molecule SIRT1 activator-enzyme complex
  512. Sirt1 Is a Regulator of Bone Mass and a Repressor of Sost Encoding for Sclerostin, a Bone Formation Inhibitor
  513. Metabolic Stress Modulates Alzheimer’s β-Secretase Gene Transcription via SIRT1-PPARγ-PGC-1 in Neurons
  514. Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model
  515. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization
  516. Antidiabetic activity of resveratrol, a known SIRT1 activator in a genetic model for type‐2 diabetes
  517. Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure
  518. Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling
  519. SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-γ Co-activator-1α (PGC-1α) Gene in Skeletal Muscle through the PGC-1α Autoregulatory Loop and Interaction with MyoD
  520. SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes
  521. Oleic Acid Stimulates Complete Oxidation of Fatty Acids through Protein Kinase A-dependent Activation of SIRT1-PGC1α Complex
  522. Age-associated decrease of SIRT1 expression in rat hippocampus: Prevention by late onset caloric restriction
  523. SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth
  524. SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells
  525. Tumor necrosis factor α–mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes
  526. Sirt1 Promotes Axonogenesis by Deacetylation of Akt and Inactivation of GSK3
  527. Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1
  528. Towards elucidating the role of SirT1 in osteoarthritis.
  529. Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis
  530. Sirt1 regulates canonical TGF-β signalling to control fibroblast activation and tissue fibrosis
  531. Resveratrol protects cardiomyocytes from oxidative stress through SIRT1 and mitochondrial biogenesis signaling pathways
  532. Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti‐aging and metabolic effects of sirtuins
  533. SirT1 in muscle physiology and disease: lessons from mouse models
  534. Role of NAD‐dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin‐induced cell death in vertebrate cells
  535. Expression of SIRT1 in Gastric Cardiac Cancer and Its Clinicopathologic Significance
  536. Resveratrol Protects HUVECs from Oxidized-LDL Induced Oxidative Damage by Autophagy Upregulation via the AMPK/SIRT1 Pathway
  537. Resveratrol‐mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation
  538. The Evolutionarily Conserved Longevity Determinants HCF-1 and SIR-2.1/SIRT1 Collaborate to Regulate DAF-16/FOXO
  539. Deacetylation by SIRT1 Reprograms Inflammation and Cancer
  540. Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar
  541. SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice
  542. Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases
  543. Metabolic actions of hypothalamic SIRT1
  544. SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells
  545. SIRT1 and NAD as regulators of ageing
  546. Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis
  547. The role of Sirt1: At the crossroad between promotion of longevity and protection against Alzheimer’s disease neuropathology
  548. Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network
  549. Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells
  550. SIRT1 Gene Polymorphisms Affect the Protein Expression in Cardiovascular Diseases
  551. SIRT1 Promotes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein Stability
  552. SIRT1 inactivation induces inflammation through the dysregulation of autophagy in human THP-1 cells
  553. SIRT1 Takes a Backseat to AMPK in the Regulation of Insulin Sensitivity by Resveratrol
  554. Protection by EGb 761 against β-amyloid-induced neurotoxicity: Involvement of NF-κB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation
  555. Impact of Sirt1 on mammalian aging
  556. The role of SirT1 in muscle mitochondrial turnover
  557. SIRT1 Transcription Is Decreased in Visceral Adipose Tissue of Morbidly Obese Patients with Severe Hepatic Steatosis
  558. AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation
  559. P53 and Sirt1: Routes of metabolism and genome stability
  560. SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines
  561. Aberrant Cytoplasm Localization and Protein Stability of SIRT1 is Regulated by PI3K/IGF-1R Signaling in Human Cancer Cells
  562. SIRT1 signalling protects mouse oocytes against oxidative stress and is deregulated during aging
  563. Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions
  564. Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells
  565. Sirt1, a Negative Regulator of Matrix Metalloproteinase-9 in Diabetic Retinopathy
  566. SIRT1 Negatively Regulates the Activities, Functions, and Protein Levels of hMOF and TIP60
  567. The Time of Metabolism: NAD+, SIRT1, and the Circadian Clock
  568. Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation
  569. SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin‐like growth factor receptor pathway
  570. SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism
  571. SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation
  572. SIRT1, p66Shc, and Set7/9 in Vascular Hyperglycemic Memory
  573. mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction
  574. Downregulation of Sirt1 as aging change in advanced heart failure
  575. SIRT1 and c-Myc Promote Liver Tumor Cell Survival and Predict Poor Survival of Human Hepatocellular Carcinomas
  576. Resveratrol Inhibits the Growth of Gastric Cancer by Inducing G1 Phase Arrest and Senescence in a Sirt1-Dependent Manner
  577. SIRT1 suppresses self-renewal of adult hippocampal neural stem cells
  578. Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: Involvement of SIRT1 and TGF-β1 pathway
  579. The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury
  580. SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells
  581. SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse
  582. Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle
  583. Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment
  584. Diabetes Causes Bone Marrow Autonomic Neuropathy and Impairs Stem Cell Mobilization via Dysregulated p66Shc and Sirt1
  585. SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells
  586. Akt/FOXO3a/SIRT1-Mediated Cardioprotection by n-Tyrosol against Ischemic Stress in Rat in Vivo Model of Myocardial Infarction: Switching Gears toward Survival and Longevity
  587. Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy
  588. Sirt1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX
  589. The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin‐1β in human chondrocytes
  590. Emerging Roles of SIRT1 in Cancer Drug Resistance
  591. Multifaceted Modulation of SIRT1 in Cancer and Inflammation
  592. Relationship between mitochondrial DNA Copy Number and SIRT1 Expression in Porcine Oocytes
  593. Resveratrol Inhibits Ionising Irradiation-Induced Inflammation in MSCs by Activating SIRT1 and Limiting NLRP-3 Inflammasome Activation
  594. SIRT1 Contains N- and C-terminal Regions That Potentiate Deacetylase Activity
  595. Dissecting systemic control of metabolism and aging in the NAD World: The importance of SIRT1 and NAMPT‐mediated NAD biosynthesis
  596. SIRT1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in HepG2 cells via induction of oxygen-regulated protein 150
  597. Sirt1 restrains lung inflammasome activation in a murine model of sepsis
  598. SIRT1 – An Anti-Inflammatory Pathway at the Crossroads Between Metabolic Disease and Atherosclerosis
  599. Silencing Insulin Resistance through SIRT1
  600. Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC‐1α by PRMT1 and SIRT1
  601. Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway
  602. The p53/miR-34a/SIRT1 Positive Feedback Loop in Quercetin-Induced Apoptosis
  603. DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage
  604. Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma
  605. Sirt1-deficient mice exhibit an altered cartilage phenotype
  606. miR-543 promotes gastric cancer cell proliferation by targeting SIRT1
  607. The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice
  608. SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus
  609. α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase
  610. Resveratrol Improves Cardiac Contractility following Trauma-Hemorrhage by Modulating Sirt1
  611. SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling
  612. Translating cell survival and cell longevity into treatment strategies with SIRT1
  613. Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart
  614. Erythropoietin Employs Cell Longevity Pathways of SIRT1 to Foster Endothelial Vascular Integrity During Oxidant Stress
  615. Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor κB-mediated transcription
  616. SIRT1: A novel target to prevent atherosclerosis
  617. Roles of microRNA-34a targeting SIRT1 in mesenchymal stem cells
  618. Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms
  619. ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling
  620. SirT1 modulates the estrogen–insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice
  621. Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia–reperfusion injury
  622. SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia
  623. SIRT1 — a metabolic sensor that controls blood vessel growth
  624. Antitumor Effect of SIRT1 Inhibition in Human HCC Tumor Models In Vitro and In Vivo
  625. ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism
  626. SIRT1 inhibits angiotensin II-induced vascular smooth muscle cell hypertrophy
  627. Epigenetic effects of natural polyphenols: A focus on SIRT1‐mediated mechanisms
  628. SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer
  629. Hyaluronan-mediated CD44 Interaction with p300 and SIRT1 Regulates β-Catenin Signaling and NFκB-specific Transcription Activity Leading to MDR1 and Bcl-xL Gene Expression and Chemoresistance in Breast Tumor Cells
  630. Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes
  631. Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor‐induced neurite outgrowth in PC12 cells
  632. Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer
  633. Amurensin G, a Potent Natural SIRT1 Inhibitor, Rescues Doxorubicin Responsiveness via Down-Regulation of Multidrug Resistance 1
  634. Vitamin D Protects Human Endothelial Cells from H2O2 Oxidant Injury Through the Mek/Erk-Sirt1 Axis Activation
  635. Liver Steatosis and Increased ChREBP Expression in Mice Carrying a Liver Specific SIRT1 Null Mutation under a Normal Feeding Condition
  636. SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens
  637. SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function
  638. The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis
  639. Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: NAD-Dependent Histone Deacetylase SIRT1 (Sir2α)
  640. Sirt1 in cerebral ischemia
  641. SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism
  642. FoxO-dependent and -independent mechanisms mediate SirT1 effects on IGFBP-1 gene expression
  643. A Dietary Regimen of Caloric Restriction or Pharmacological Activation of SIRT1 to Delay the Onset of Neurodegeneration
  644. Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4+ T Cells
  645. Sirt1 hyperexpression in SHR heart related to left ventricular hypertrophy
  646. Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis
  647. Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity
  648. Physiological and Pathophysiological Functions of SIRT1
  649. Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats
  650. Relationship between Sirt1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse
  651. Radioprotective and Antioxidant Effect of Resveratrol in Hippocampus by Activating Sirt1
  652. SIRT1: Role in cardiovascular biology
  653. SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins
  654. SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a
  655. Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice
  656. Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma
  657. Resveratrol activates SIRT1 in a Lamin A-dependent manner
  658. Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma
  659. Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence
  660. Resveratrol Induces Vascular Smooth Muscle Cell Differentiation through Stimulation of SirT1 and AMPK
  661. A Potential Treatment of Non-Alcoholic Fatty Liver Disease with SIRT1 Activators
  662. The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome
  663. Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription
  664. Effects of Resveratrol in Patients with Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure
  665. Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice
  666. Essential Role of SIRT1 Signaling in the Nucleus Accumbens in Cocaine and Morphine Action
  667. Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition
  668. SIRT1 is dispensable for function of hematopoietic stem cells in adult mice
  669. Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity
  670. SIRT1 Activation by a c-MYC Oncogenic Network Promotes the Maintenance and Drug Resistance of Human FLT3-ITD Acute Myeloid Leukemia Stem Cells
  671. The role of SIRT1 in tumorigenesis
  672. SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome
  673. Chronic pancreatitis and pancreatic cancer demonstrate active epithelial–mesenchymal transition profile, regulated by miR-217-SIRT1 pathway
  674. Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein
  675. Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance
  676. The role of SIRT1 in diabetic kidney disease
  677. Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo
  678. Resveratrol prevents antibody-induced apoptotic death of retinal cells through upregulation of Sirt1 and Ku70
  679. SIRT1 Suppresses the Senescence-Associated Secretory Phenotype through Epigenetic Gene Regulation
  680. Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells
  681. Early Apoptotic Vascular Signaling is Determined by Sirt1 Through Nuclear Shuttling, Forkhead Trafficking, Bad, and Mitochondrial Caspase Activation
  682. Modulating effect of SIRT1 activation induced by resveratrol on Foxo1‐associated apoptotic signalling in senescent heart
  683. SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer
  684. SIRT1 in metabolic syndrome: Where to target matters
  685. SIRT1 Regulates Endothelial Notch Signaling in Lung Cancer
  686. Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression
  687. Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells
  688. CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1
  689. BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression
  690. SIRT1 protects against myocardial ischemia–reperfusion injury via activating eNOS in diabetic rats
  691. Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and telomerase regulation in triple-negative breast cancer
  692. Sirt1 Deletion Leads to Enhanced Inflammation and Aggravates Endotoxin-Induced Acute Kidney Injury
  693. Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression
  694. Inhibition of Sirt1 promotes neural progenitors toward motoneuron differentiation from human embryonic stem cells
  695. Role of Deleted in Breast Cancer 1 (DBC1) Protein in SIRT1 Deacetylase Activation Induced by Protein Kinase A and AMP-activated Protein Kinase
  696. SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase
  697. p16INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic Mechanisms
  698. Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity
  699. SIRT1 Mediates the Effect of GLP-1 Receptor Agonist Exenatide on Ameliorating Hepatic Steatosis
  700. Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats
  701. SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non–Small Cell Lung Cancers to Cisplatin and Doxorubicin
  702. SIRT1 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the Oxidative Stress and p38MAPK Pathways
  703. Nϵ-Thioacetyl-Lysine-Containing Tri-, Tetra-, and Pentapeptides as SIRT1 and SIRT2 Inhibitors
  704. Resveratrol inhibition of inducible nitric oxide synthase in skeletal muscle involves AMPK but not SIRT1
  705. SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells
  706. Role of SIRT1 and AMPK in mesenchymal stem cells differentiation
  707. Interference between PARPs and SIRT1: a novel approach to healthy ageing?
  708. Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats
  709. MicroRNA 34a Inhibits Beige and Brown Fat Formation in Obesity in Part by Suppressing Adipocyte Fibroblast Growth Factor 21 Signaling and SIRT1 Function
  710. Fructose induces gluconeogenesis and lipogenesis through aSIRT1-dependent mechanism
  711. NAD+-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1
  712. SIRT1 Deficiency Downregulates PTEN/JNK/FOXO1 Pathway to Block Reactive Oxygen Species-Induced Apoptosis in Mouse Embryonic Stem Cells
  713. Identification, stability and expression of Sirt1 antisense long non-coding RNA
  714. A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53
  715. A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers
  716. SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism
  717. miR‐520c and miR‐373 upregulate MMP9 expression by targeting mTOR and SIRT1, and activate the Ras/Raf/MEK/Erk signaling pathway and NF‐κB factor in human fibrosarcoma cells
  718. SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1α–Dependent Glycolysis
  719. Sequential Actions of SIRT1-RELB-SIRT3 Coordinate Nuclear-Mitochondrial Communication during Immunometabolic Adaptation to Acute Inflammation and Sepsis
  720. SIRT1 associates with eIF2-alpha and regulates the cellular stress response
  721. Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity
  722. SIRT1 overexpression decreases cisplatin-induced acetylation of NF-κB p65 subunit and cytotoxicity in renal proximal tubule cells
  723. Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation
  724. Angiogenic Deficiency and Adipose Tissue Dysfunction Are Associated with Macrophage Malfunction in SIRT1−/− Mice
  725. Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice
  726. The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition
  727. The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
  728. Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer
  729. FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway
  730. Flavonoid Fraction of Bergamot Juice Reduces LPS-Induced Inflammatory Response through SIRT1-Mediated NF-κB Inhibition in THP-1 Monocytes
  731. The Histone Deacetylase SIRT1 Controls Male Fertility in Mice Through Regulation of Hypothalamic-Pituitary Gonadotropin Signaling
  732. FoxO1 and SIRT1 Regulate β-Cell Responses to Nitric Oxide
  733. SIRT1-FOXO3a Regulate Cocaine Actions in the Nucleus Accumbens
  734. Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats
  735. MiR-217 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation by down-regulation of SIRT1
  736. SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice
  737. SIRT1 and Caloric Restriction: An Insight Into Possible Trade-Offs Between Robustness and Frailty
  738. Induction of Sirt1 by Mechanical Stretch of Skeletal Muscle through the Early Response Factor EGR1 Triggers an Antioxidative Response
  739. Fasting protects liver from ischemic injury through Sirt1-mediated downregulation of circulating HMGB1 in mice
  740. Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer
  741. SIRT1 silencing confers neuroprotection through IGF‐1 pathway activation
  742. Quercetin is a potent anti‐atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation
  743. PPARα and Sirt1 Mediate Erythropoietin Action in Increasing Metabolic Activity and Browning of White Adipocytes to Protect Against Obesity and Metabolic Disorders
  744. Cross-talk between SIRT1 and p66Shc in vascular diseases
  745. Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients
  746. Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX
  747. Resveratrol reduces acute lung injury in a LPS‑induced sepsis mouse model via activation of Sirt1
  748. SirT1 brings stemness closer to cancer and aging
  749. SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer’s Disease
  750. Resveratrol reduces acute lung injury in a LPS‑induced sepsis mouse model via activation of Sirt1
  751. SirT1 brings stemness closer to cancer and aging
  752. SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer’s Disease
  753. SIRT1 enhances matrix metalloproteinase‐2 expression and tumor cell invasion in prostate cancer cells
  754. High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients
  755. Sirtuin1 (Sirt1) Promotes Cortical Bone Formation by Preventing β-Catenin Sequestration by FoxO Transcription Factors in Osteoblast Progenitors
  756. Omentin-1, a new adipokine, promotes apoptosis through regulating Sirt1-dependent p53 deacetylation in hepatocellular carcinoma cells
  757. Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice
  758. Testosterone Deficiency Accelerates Neuronal and Vascular Aging of SAMP8 Mice: Protective Role of eNOS and SIRT1
  759. Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-β25–35 in rat cortical neurons
  760. Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide
  761. Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer’s disease neuropathological deficits
  762. PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells
  763. Critical Reviews™ in Eukaryotic Gene Expression
  764. Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells
  765. NO Targets SIRT1
  766. SIRT1 Directly Regulates SOX2 to Maintain Self‐Renewal and Multipotency in Bone Marrow‐Derived Mesenchymal Stem Cells
  767. Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells
  768. Reciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor α activity and co-activator synergy
  769. SIRT1 Regulation of Wakefulness and Senescence-Like Phenotype in Wake Neurons
  770. SIRT1 Positively Regulates Breast Cancer Associated Human Aromatase (CYP19A1) Expression
  771. PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity
  772. SIRT1 modulation of adipogenesis and adipose function
  773. Changes in SIRT1 Expression and Its Downstream Pathways in Age-Related Cataract in Humans
  774. The Type III Histone Deacetylase Sirt1 Protein Suppresses p300-mediated Histone H3 Lysine 56 Acetylation at Bclaf1 Promoter to Inhibit T Cell Activation
  775. The SIRT1 Modulators AROS and DBC1 Regulate HSF1 Activity and the Heat Shock Response
  776. Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling
  777. Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway
  778. Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma
  779. Resveratrol is neuroprotective because it is not a direct activator of Sirt1—A hypothesis
  780. SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling
  781. Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells
  782. Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model
  783. Hydrogen sulfide protects against apoptosis under oxidative stress through SIRT1 pathway in H9c2 cardiomyocytes
  784. Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas
  785. Tat-SIRT1 Tango
  786. Exendin-4 attenuates endoplasmic reticulum stress through a SIRT1-dependent mechanism
  787. Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65
  788. SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway
  789. High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T‐cell leukemia cells
  790. Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion
  791. Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction
  792. Modulations of hMOF autoacetylation by SIRT1 regulate hMOF recruitment and activities on the chromatin
  793. SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase gene
  794. Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1/PGC-1α signaling pathway
  795. Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues
  796. SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin
  797. SIRT1 Modulates Aggregation and Toxicity through Deacetylation of the Androgen Receptor in Cell Models of SBMA
  798. SIRT1 links CIITA deacetylation to MHC II activation
  799. Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular Dystrophy
  800. SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age-related neoplasms
  801. Dietary Resveratrol Prevents Development of High-Grade Prostatic Intraepithelial Neoplastic Lesions: Involvement of SIRT1/S6K Axis
  802. Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expression
  803. A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells
  804. Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase
  805. Transcriptional Corepressor SMILE Recruits SIRT1 to Inhibit Nuclear Receptor Estrogen Receptor-related Receptor γ Transactivation
  806. Sirtuin-1 (SIRT1) Is Required for Promoting Chondrogenic Differentiation of Mesenchymal Stem Cells
  807. Interactions between DBC1 and SIRT1 arederegulated in breast cancer cells
  808. SIRT1 Protects Against Oxidative Stress‐Induced Endothelial Progenitor Cells Apoptosis by Inhibiting FOXO3a via FOXO3a Ubiquitination and Degradation
  809. Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis
  810. AROuSing SIRT1: Identification of a Novel Endogenous SIRT1 Activator
  811. Activation of SIRT1 by Resveratrol Represses Transcription of the Gene for the Cytosolic Form of Phosphoenolpyruvate Carboxykinase (GTP) by Deacetylating Hepatic Nuclear Factor 4α
  812. Sirt1 is involved in energy metabolism: The role of chronic ethanol feeding and resveratrol
  813. SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation
  814. NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells
  815. SIRT1 and CLOCK 3111T>C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity
  816. Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro
  817. SIRT1 Is Downregulated in Gastric Cancer and Leads to G1-phase Arrest via NF-κB/Cyclin D1 Signaling
  818. Accelerated senescence of cord blood endothelial progenitor cells in premature neonates is driven by SIRT1 decreased expression
  819. Resveratrol inhibited Tat-induced HIV-1 LTR transactivation via NAD+-dependent SIRT1 activity
  820. SIRT1 signaling as potential modulator of skeletal muscle diseases
  821. Hydrogen sulfide prevents H2O2-induced senescence in human umbilical vein endothelial cells through SIRT1 activation
  822. Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML
  823. SIRT1 Polymorphism, Long-Term Survival and Glucose Tolerance in the General Population
  824. A fluorometric assay of SIRT1 deacetylation activity through quantification of nicotinamide adenine dinucleotide
  825. Linking DNA Damage, NAD+/SIRT1, and Aging
  826. SIRT1 is decreased during relapses in patients with multiple sclerosis
  827. Aging and exercise affect the level of protein acetylation and SIRT1 activity in cerebellum of male rats
  828. Resveratrol Inhibits CD4+ T Cell Activation by Enhancing the Expression and Activity of Sirt1
  829. Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents
  830. Selenium nanoparticles involve HSP-70 and SIRT1 in preventing the progression of type 1 diabetic nephropathy
  831. Negative regulation of stress‐induced matrix metalloproteinase‐9 by Sirt1 in skin tissue
  832. SIRT1 regulates the ribosomal DNA locus: Epigenetic candles twinkle longevity in the Christmas tree
  833. The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance
  834. Sirt1 inhibits the transcription factor CREB to regulate pituitary growth hormone synthesis
  835. SIRT1 Undergoes Alternative Splicing in a Novel Auto-Regulatory Loop with p53
  836. The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation
  837. Emerging roles of SIRT1 in fatty liver diseases
  838. Role of SIRT1 in autoimmune demyelination and neurodegeneration
  839. Genetic study between SIRT1, PPARD, PGC-1α genes and Alzheimer’s disease
  840. SIRT1 modulates high‐mobility group box 1‐induced osteoclastogenic cytokines in human periodontal ligament cells
  841. Peripheral Blood Monocyte Sirt1 Expression Is Reduced in Patients with Coronary Artery Disease
  842. A Novel Chalcone Polyphenol Inhibits the Deacetylase Activity of SIRT1 and Cell Growth in HEK293T Cells
  843. Sirt1 protects against thrombomodulin down-regulation and lung coagulation after particulate matter exposure
  844. NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchial epithelial cells
  845. Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia
  846. Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically‐obese db/db mice
  847. Resveratrol-induced SIRT1 activation promotes neuronal differentiation of human bone marrow mesenchymal stem cells
  848. Curcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro
  849. The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis
  850. Sirt1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells
  851. SIRT1 variants are associated with aging in a healthy Han Chinese population
  852. IL-15 Overexpression Promotes Endurance, Oxidative Energy Metabolism, and Muscle PPARδ, SIRT1, PGC-1α, and PGC-1β Expression in Male Mice
  853. Spinal SIRT1 Activation Attenuates Neuropathic Pain in Mice
  854. MicroRNA-34a Induces Vascular Smooth Muscle Cells Senescence by SIRT1 Downregulation and Promotes the Expression of Age-Associated Pro-inflammatory Secretory Factors
  855. SIRT1 Knockdown Promotes Neural Differentiation and Attenuates the Heat Shock Response
  856. Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function
  857. Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes
  858. SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183
  859. SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer
  860. Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness
  861. High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma
  862. Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway
  863. Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of Manganese Superoxide Dismutase via the SIRT1/FoxO3a Pathway
  864. An exploratory double‐blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington’s disease
  865. Hepatitis B virus X (HBX) protein upregulates β-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase
  866. Targeting Mutant p53 by a SIRT1 Activator YK-3-237 Inhibits the Proliferation of Triple-Negative Breast Cancer Cells
  867. Simvastatin attenuates TNF‑α‑induced apoptosis in endothelial progenitor cells via the upregulation of SIRT1
  868. Dual role of SIRT1 in UVB-induced skin tumorigenesis
  869. SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1
  870. Could Sirt1-mediated epigenetic effects contribute to the longevity response to dietary restriction and be mimicked by other dietary interventions?
  871. SIRT1 is a Direct Coactivator of Thyroid Hormone Receptor β1 with Gene-Specific Actions
  872. SIRT1, AMP-activated protein kinase phosphorylation and downstream kinases in response to a single bout of sprint exercise: influence of glucose ingestion
  873. Activation of miR-34a/SIRT1/p53 signaling contributes to cochlear hair cell apoptosis: implications for age-related hearing loss
  874. SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-κB pathway
  875. Effect of caloric restriction on the SIRT1/mTOR signaling pathways in senile mice
  876. Sirt1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuating function of miR-34a
  877. Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al 2 O 3 ) nanoparticles in mouse skin epithelial cells
  878. TNF-α inhibits PPARβ/δ activity and SIRT1 expression through NF-κB in human adipocytes
  879. Fenofibrate increases cardiac autophagy via FGF21/SIRT1 and prevents fibrosis and inflammation in the hearts of Type 1 diabetic mice
  880. Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high-fat-diet feeding
  881. Glucagon-Like Peptide 1 Inhibits the Sirtuin Deacetylase SirT1 to Stimulate Pancreatic β-Cell Mass Expansion
  882. Resveratrol Facilitates Pain Attenuation in a Rat Model of Neuropathic Pain Through the Activation of Spinal Sirt1
  883. Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1
  884. SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin
  885. SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma
  886. Resveratrol protects against doxorubicin‐induced cardiotoxicity in aged hearts through the SIRT1‐USP7 axis
  887. Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescence
  888. Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway
  889. The SIRT1/HIF2α Axis Drives Reductive Glutamine Metabolism under Chronic Acidosis and Alters Tumor Response to Therapy
  890. Korean Red Ginseng attenuates ethanol-induced steatosis and oxidative stress via AMPK/Sirt1 activation
  891. Myristica fragrans Houtt. Methanolic Extract inducesApoptosis in a Human Leukemia Cell Line throughSIRT1 mRNA Downregulation
  892. Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1
  893. Cytoprotective and anti‐inflammatory effects of melatonin in hydrogen peroxide‐stimulated CHON‐001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway
  894. Modulation of SIRT1-Foxo1 Signaling axis by Resveratrol: Implications in Skeletal Muscle Aging and Insulin Resistance
  895. Resveratrol supplement inhibited the NF-κB inflammation pathway through activating AMPKα-SIRT1 pathway in mice with fatty liver
  896. The Role of SIRT1 on Angiogenic and Odontogenic Potential in Human Dental Pulp Cells
  897. Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver
  898. SIRT1 expression is associated with poor prognosis of lung adenocarcinoma
  899. Differential roles of Sirt1 in HIF-1α and HIF-2α mediated hypoxic responses
  900. Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice
  901. Low-Frequency Electroacupuncture Improves Insulin Sensitivity in Obese Diabetic Mice through Activation of SIRT1/PGC-1 in Skeletal Muscle
  902. Melatonin facilitates adipose‐derived mesenchymal stem cells to repair the murine infarcted heart via the SIRT1 signaling pathway
  903. Modulatory effect of resveratrol on SIRT1, SIRT3, SIRT4, PGC1α and NAMPT gene expression profiles in wild-type adult zebrafish liver
  904. FoxM1 regulates Sirt1 expression in glioma cells
  905. SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress
  906. Age-dependent tissue expression patterns of Sirt1 in senescence-accelerated mice
  907. Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction
  908. A Role for SIRT1 in the Hypoxic Response
  909. Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells
  910. Roles of SIRT1 in leukemogenesis
  911. SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice
  912. SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements
  913. SIRT1 activation rescues doxorubicin-induced loss of functional competence of human cardiac progenitor cells
  914. Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1
  915. Down-Regulation of mir-221 and mir-222 Restrain Prostate Cancer Cell Proliferation and Migration That Is Partly Mediated by Activation of SIRT1
  916. WISP1 Neuroprotection Requires FoxO3a Post-Translational Modulation with Autoregulatory Control of SIRT1
  917. A Remarkable Age-Related Increase in SIRT1 Protein Expression against Oxidative Stress in Elderly: SIRT1 Gene Variants and Longevity in Human
  918. Intracellular NAMPT–NAD+–SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors
  919. Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer’s disease via SIRT1/NF-κB pathway
  920. Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function
  921. SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation
  922. SIRT1 Regulation Modulates Stroke Outcome
  923. Hepatic Deletion of SIRT1 Decreases Hepatocyte Nuclear Factor 1α/Farnesoid X Receptor Signaling and Induces Formation of Cholesterol Gallstones in Mice
  924. Structure-Based Design of Pseudopeptidic Inhibitors for SIRT1 and SIRT2
  925. SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy
  926. SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer
  927. SIRT1 Expression Is Associated with the Chemotherapy Response and Prognosis of Patients with Advanced NSCLC
  928. Resveratrol prevents dexamethasone-induced expression of the muscle atrophy-related ubiquitin ligases atrogin-1 and MuRF1 in cultured myotubes through a SIRT1-dependent mechanism
  929. Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells
  930. SIRT1 Is Necessary for Proficient Telomere Elongation and Genomic Stability of Induced Pluripotent Stem Cells
  931. Energy sensing factors PGC-1α and SIRT1 modulate PXR expression and function
  932. Aberrant expression pattern of histone acetylation modifiers and mitigation of lupus by SIRT1-siRNA in MRL/lpr mice
  933. Activating SIRT1: a new strategy to prevent atherosclerosis?
  934. A BCL6/BCOR/SIRT1 Complex Triggers Neurogenesis and Suppresses Medulloblastoma by Repressing Sonic Hedgehog Signaling
  935. MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1
  936. Dioscin alleviates BDL- and DMN-induced hepatic fibrosis via Sirt1/Nrf2-mediated inhibition of p38 MAPK pathway
  937. Role of SIRT1 in Heat Stress- and Lipopolysaccharide-induced Immune and Defense Gene Expression in Human Dental Pulp Cells
  938. SIRT1 is required for the effects of rapamycin on high glucose-inducing mesangial cells senescence
  939. GLP-1 receptor agonist promotes brown remodelling in mouse white adipose tissue through SIRT1
  940. SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis
  941. Cilostazol suppresses β‐amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1‐coupled retinoic acid receptor‐β
  942. SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia
  943. Roles of SIRT1 in High Glucose-induced Endothelial Impairment: Association with Diabetic Atherosclerosis
  944. SIRT1-metabolite binding histone macroH2A1.1 protects hepatocytes against lipid accumulation
  945. SIRT1 Promotes RGC Survival and Delays Loss of Function Following Optic Nerve Crush
  946. The role of SIRT1 in diabetic cardiomyopathy
  947. Ectopic expression of miR-494 inhibited the proliferation, invasion and chemoresistance of pancreatic cancer by regulating SIRT1 and c-Myc
  948. SIRT1 Regulates CD40 Expression Induced by TNF-α via NF-ĸB Pathway in Endothelial Cells
  949. Stress Inducibility of SIRT1 and Its Role in Cytoprotection and Cancer
  950. Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis
  951. Sirt1: Role Under the Condition of Ischemia/Hypoxia
  952. Sirtuin 1 (SIRT1) Activation Mediates Sildenafil Induced Delayed Cardioprotection against Ischemia-Reperfusion Injury in Mice
  953. The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing
  954. The Full Capacity of AICAR to Reduce Obesity-Induced Inflammation and Insulin Resistance Requires Myeloid SIRT1
  955. The PPARδ-mediated inhibition of angiotensin II-induced premature senescence in human endothelial cells is SIRT1-dependent
  956. Resveratrol provides neuroprotection by inhibiting phosphodiesterases and regulating the cAMP/AMPK/SIRT1 pathway after stroke in rats
  957. Poor glycaemic control in type 2 diabetes patients reduces endothelial progenitor cell number by influencing SIRT1 signalling via platelet-activating factor receptor activation
  958. Fortifying the Link between SIRT1, Resveratrol, and Mitochondrial Function
  959. Visfatin is expressed in human granulosa cells: regulation by metformin through AMPK/SIRT1 pathways and its role in steroidogenesis
  960. Overexpression of SIRT1 Induced by Resveratrol and Inhibitor of miR-204 Suppresses Activation and Proliferation of Microglia
  961. Dendritic cell SIRT1–HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1
  962. Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway
  963. Resveratrol relieves ischemia‑induced oxidative stress in the hippocampus by activating SIRT1
  964. Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer
  965. Inhibition of AMP-activated Protein Kinase α (AMPKα) by Doxorubicin Accentuates Genotoxic Stress and Cell Death in Mouse Embryonic Fibroblasts and Cardiomyocytes ROLE OF p53 AND SIRT1
  966. Angiogenesis Inhibitor Vasohibin-1 Enhances Stress Resistance of Endothelial Cells via Induction of SOD2 and SIRT1
  967. Circadian Control of Fatty Acid Elongation by SIRT1 Protein-mediated Deacetylation of Acetyl-coenzyme A Synthetase 1
  968. Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats
  969. The Effects of SIRT1 on Alzheimer’s Disease Models
  970. Nε-Modified lysine containing inhibitors for SIRT1 and SIRT2
  971. Nrf2/antioxidant defense pathway is involved in the neuroprotective effects of Sirt1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning
  972. Hepatic menin recruits SIRT1 to control liver steatosis through histone deacetylation
  973. Intra‐articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF‐2α
  974. SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system
  975. miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling
  976. SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention – the TULIP Study
  977. Long non-coding RNA TUG1 promotes cervical cancer progression by regulating the miR-138-5p-SIRT1 axis
  978. SIRT1 Activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease
  979. Genetic analysis of the SIRT1 gene promoter in myocardial infarction
  980. Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway
  981. Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology
  982. Resveratrol protects against spinal cord injury by activating autophagy and inhibiting apoptosis mediated by the SIRT1/AMPK signaling pathway
  983. Resveratrol Targeting of Carcinogen-Induced Brain Endothelial Cell Inflammation Biomarkers MMP-9 and COX-2 is Sirt1-Independent
  984. Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis
  985. SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer
  986. SIRT1 regulates adaptive response of the growth hormone–insulin-like growth factor-I axis under fasting conditions in liver
  987. Activating Transcription Factor 4 Confers a Multidrug Resistance Phenotype to Gastric Cancer Cells through Transactivation of SIRT1 Expression
  988. SIRT1 and SIRT5 activity expression and behavioral responses to calorie restriction
  989. Delphinidin‐3‐glucoside protects human umbilical vein endothelial cells against oxidized low‐density lipoprotein‐induced injury by autophagy upregulation via the AMPK/SIRT1 signaling pathway
  990. Involvement of the p65/RelA subunit of NF-κB in TNF-α-induced SIRT1 expression in vascular smooth muscle cells
  991. SIRT1, a Calorie Restriction Mimetic, in a New Therapeutic Approach for Type 2 Diabetes Mellitus and Diabetic Vascular Complications
  992. Myeloid Deletion of SIRT1 Aggravates Serum Transfer Arthritis in Mice via Nuclear Factor-κB Activation
  993. Age-related loss of SirT1 expression results in dysregulated human vascular smooth muscle cell function
  994. Kaempferol protects cardiomyocytes against anoxia/reoxygenation injury via mitochondrial pathway mediated by SIRT1
  995. Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells
  996. Sirt1-Sirt3 axis regulates human blood-brain barrier permeability in response to ischemia
  997. Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: Coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile
  998. Ambient glucose levels qualify the potency of insulin myogenic actions by regulating SIRT1 and FoxO3a in C2C12 myocytes
  999. SIRT1/PGC-1Un axe neuroprotecteur ?
  1000. SIRT1 Regulates Lysosome Function and Exosome Secretion

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