APIGENIN

Apigenin 200:1

100g $250 300 1/8 tsp servings

Dosage: Start 1 tsp a day first 2 weeks then you can move down to 1/2 tsp a day for 2 weeks then 1/4 tsp a day for 2 weeks then 1/8 tsp as needed.

the strongest Apigenin on the planet 

Want to grow some new brain cells?

It’s called adult neurogenesis.

 

The hippocampus is well known to play important roles in learning and memory, and this adult DG neurogenesis has not only been implicated in memory but has led to ideas that it could be harnessed to treat neurodegenerative and neuropsychiatric disorders.”

Plant compound found in spices, herbs increases brain connections. Flavonoid apigenin has potential to treat diseases like schizophrenia, depression, Alzheimer’s and Parkinson’s. 

“Apigenin, a substance found in parsley, thyme, chamomile and red pepper, improves neuron formation and strengthens the connections between brain cells, new lab research demonstrates.”

New approach in treatment of brain injury: Neurotrophic effects of Apigenin

POTENT SASP INHIBITOR

During senescence, cells express molecules called senescence-associated secretory phenotype (SASP), including growth factors, proinflammatory cytokines, chemokines, and proteases. The SASP induces a chronic low-grade inflammation adjacent to cells and tissues, leading to degenerative diseases. The anti- inflammatory activity of flavonoids was investigated on SASP expression in senescent fibroblasts. Effects of flavonoids on SASP expression such as IL-1a, IL-1b, IL-6, IL-8, GM-CSF, CXCL1, MCP-2 and MMP-3 and signaling molecules were examined in bleomycin-induced senescent BJ cells. In vivo activity of apigenin on SASP suppression was identified in the kidney of aged rats.

Among the five naturally-occurring flavonoids initially tested, apigenin and kaempferol strongly inhibited the expression of SASP. These flavonoids inhibited NF-kB p65 activity via the IRAK1/IkBa signaling pathway and expression of IkBz. Blocking IkBz expression especially reduced the expression of SASP. A structure-activity relationship study using some synthetic flavones demonstrated that hydroxyl substitutions at C-20,30,40,5 and 7 were important in inhibiting SASP production. Finally, these results were verified by results showing that the oral administration of apigenin significantly reduced elevated levels of SASP and IkBz mRNA in the kidneys of aged rats.

This study is the first to show that certain flavonoids are inhibitors of SASP production, partially related to NF-kB p65 and IkBz signaling pathway, and may effectively protect or alleviate chronic low-grade inflammation in degenerative diseases such as cardiovascular diseases and late-stage cancer. Inhibitory activity of apigenin on IL-6, IL-8, and IL-1b was the most potent among the five flavonoids that were tested (86.5%, 60.9%, and 94.9% at 10 mM, respectively).

 

Apigenin and preventing/reversing alcohol liver injury

Our present results demonstrate that apigenin can exert an inhibitory effect on ethanol-induced oxidative stress and LPS-induced inflammatory response in the cultured BRL cells, and its mechanisms may be related to the reduction of CYP2E1 expression, increment of antioxidant ability, and regulation of inflammatory gene expression. These effects of apigenin may be good for the prevention and treatment of alcoholic liver injury.”

 

You want high NAD+ levels. (CD38 is a key enzyme involved in the degradation of NAD+) Apigenin blocks CD38

“Metabolic syndrome is a growing health problem worldwide. It is therefore imperative to develop new strategies to treat this pathology. In the past years, the manipulation of NAD+ metabolism has emerged as a plausible strategy to ameliorate metabolic syndrome. In particular, an increase in cellular NAD+ levels has beneficial effects, likely because of the activation of sirtuins. Previously, we reported that CD38 is the primary NAD+ase in mammals. Moreover, CD38 knockout mice have higher NAD+ levels and are protected against obesity and metabolic syndrome.

Here, we show that CD38 regulates global protein acetylation through changes in NAD+ levels and sirtuin activity. In addition, we characterize two CD38 inhibitors: quercetin and apigenin. We show that pharmacological inhibition of CD38 results in higher intracellular NAD+ levels and that treatment of cell cultures with apigenin decreases global acetylation as well as the acetylation of p53 and RelA-p65. Finally, apigenin administration to obese mice increases NAD+ levels, decreases global protein acetylation, and improves several aspects of glucose and lipid homeostasis.”

Scientists are discovering new ways that NAD+ facilitates healthy longevity. NAD+ levels markedly decline with age, creating an energy deficit that decreases the body’s ability to retain youthful function.  To give you an idea how impactful NAD+ can be, by age 50 a typical person may have only half the NAD+ they did in youth. By age 80, NAD+ levels drop to only 1% to 10% expressed in youth.  Deficiency of NAD+ predisposes us to accelerated aging and impedes our ability to fully benefit from resveratrol.

 

Apigenin prevents age related testosterone decline

(APIGENIN) : Decreases COX2 while increasing StAR thus suppressing age related testosterone decline. “During the course of male aging, circulating levels of testosterone decline, resulting in decreases in muscle function, bone density, sex function and other physiological functions. It was also observed that serum testosterone concentrations were significantly lower in men with Alzheimer’s disease in comparison to non-demented and age-matched men.

Supplementation with testosterone reduced β-amyloid peptide and hyperphosphorylation of τ protein, two bio-markers of the disease. The studies suggested that low blood testosterone is a possible risk factor for development of Alzheimer’s disease. To improve the health of aging males, especially those suffering from age-associated hypogonadism, we have been attempting to determine if it is possible to delay the age-related decline in blood testosterone concentration.

Testosterone is mainly synthesized in testicular Leydig cells from substrate cholesterol and then released into the circulation. It is known that the levels of blood testosterone are affected by multiple physiological and biochemical factors associated with aging. It has also been shown that the primary site for the decline in blood testosterone appears to be at the level of testosterone biosynthesis in aging Leydig cells. The rate-limiting step in testosterone biosynthesis is the transfer of the substrate cholesterol from the outer to the inner mitochondrial membrane to initiate the steroidogenic process.

Previous studies reported that a newly synthesized protein induced by trophic hormone, namely the steroidogenic acute regulatory (StAR) protein, plays a critical function at this step by facilitating the mitochondrial cholesterol transfer. A large body of evidence demonstrated that the levels of StAR protein expression strongly affect testosterone production in Leydig cells. However, StAR protein expression also decreases during the course of Leydig cell aging, and the cholesterol supply to the mitochondrial inner membrane is reduced in aged Leydig cells. These studies implicated the involvement of an age-related decline in StAR gene expression in the decrease in testosterone production.

In addition, our studies have demonstrated that expression of cyclooxygenase-2 (COX2, an isoform of cyclooxygenase) increases during Leydig cell aging, a process that enhances the COX2-dependent inhibition of StAR gene expression. Consequently, the age-related increase in COX2 results in decreases in StAR gene expression and testosterone biosynthesis. When COX2 activity was inhibited, StAR protein expression and testosterone production were increased. Moreover, feeding aged rats with a selective COX2 inhibitor reversed the decreased StAR protein and blood testosterone concentration.

Further studies showed that the observed COX2-dependent inhibition of StAR gene expression involves the negative signaling through an autocrine loop consisting of COX2-thromboxane A synthase (TBXAS)-thromboxane A2 (TBX A2)-receptor, in which TBX A2 generated by the co-action of COX2 and TBXAS is released from Leydig cells, and then binds to its receptors. These studies further indicated that the TBX A2-receptor complex regulate the expression or stability of DAX-1 (dosage sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene-1) protein, a transcriptional repressor of StAR gene expression.

Blocking the COX2-dependent signaling through this loop reduced DAX-1 protein and increased the sensitivity of Leydig cells to trophic hormone stimulation, resulting in dramatic increases in StAR gene expression and testosterone production in aged Leydig cells. These studies suggested that it is possible to delay the age-related decline in testosterone production by interrupting the signaling through this loop at any step, by either inhibiting the activity of COX2 or TBXAS, or by blocking the TBX A2 receptor.

We have continued the studies in an attempt to identify natural compounds in food or food supplements that could enhance StAR gene expression in Leydig cells by intervention in the mechanism.  After screening a group of compounds, the present study identified a natural flavonoid, apigenin that interrupted the COX2-dependent signaling by blocking the TBX A2 receptor and increased StAR gene expression and steroidogenesis in mouse Leydig cells.”

 

Apigenin as an Anti-Aging Skin Treatment

Skin aging is a complex biological process prematurely induced by innate and external factors. We evaluated the anti-aging effects of apigenin, a plant flavone, on human skin exposed to ultraviolet radiation. A total of 25 female subjects applied a 10% apigenin- containing regimen (eye cream, moisturizer, and serum) to the skin of their faces for eight weeks (56 days), twice daily, once in the morning and once in the evening.

At day 28 (the four-week mark) and day 56 (the eight-week mark), we analyzed the treated areas for dermal density, skin elasticity; the length and area of crow’s feet; transepidermal water loss; facial and skin tone evenness; brightness; moisture retention/hydration; the size, depth, and number of wrinkles; roughness; skin hydration; and barrier function. We also evaluated the subjects’ perception and tolerance of the cream. The test regimen was well-tolerated by the study participants for various subjective parameters, including sensory attributes and improvement of overall skin conditions.

The anti-aging regimen did not affect the skin barrier function and maintained baseline hydration. The test treatment provided statistically significant improvements in skin roughness and the depth of fine lines and wrinkles for fine wrinkles after 28 days of treatment. Furthermore, significant improvements were measured in skin elasticity for the firmness, maximal amplitude, and extensibility parameters after 56 days of treatment. The anti-aging regimen had a significant effect on skin elasticity. Patient perception of the apigenin containing regimen was excellent. Our findings support the evidence that apigenin can improve several markers of aging. Apigenin use in skin care products may contribute to objectively improved parameters of skin health and subjective appearance of photo-aged skin.

 

Apigenin has been demonstrated to have VERY POWERFUL anti anxiety, anti depressive, anti Alzheimer’s and anti-excitotoxic neuroprotective capabilities

What is EXCITOTOXICITY? 

“Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamate and similar substances. This occurs when receptors for the excitatory neurotransmitter glutamate (glutamate receptors) such as the NMDA receptor and AMPA receptor are overactivated by glutamatergic storm.

Excitotoxins like NMDA and kainic acid which bind to these receptors, as well as pathologically high levels of glutamate, can cause excitotoxicity by allowing high levels of calcium ions (Ca2+) to enter the cell.[1][2] Ca2+ influx into cells activates a number of enzymes, including phospholipases, endonucleases, and proteases such as calpain. These enzymes go on to damage cell structures such as components of the cytoskeleton, membrane, and DNA.

Excitotoxicity may be involved in spinal cord injury, stroke, traumatic brain injury, hearing loss (through noise overexposure or ototoxicity), and in neurodegenerative diseases of the central nervous system (CNS) such as multiple sclerosis, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Parkinson’s disease, alcoholism or alcohol withdrawal and especially over-rapid benzodiazepine withdrawal, and also Huntington’s disease.[3][4] Other common conditions that cause excessive glutamate concentrations around neurons are hypoglycemia.”

 

Apigenin modulates GABAergic and glutamatergic transmission in cultured cortical neurons

Finally, apigenin is neuroprotective against glutamate-induced neurotoxicity in cerebellar and cortical neurons in culture. Our data reveal the antagonistic effect of apigenin on GABA and NMDAchannels. While the inhibition on GABA receptorcannot explain the effects of the drug in vivo our data on NMDA channels reveal a new target of apigenin. A reduction of the network excitability could thus account for the sedative effects. Furthermore, our data suggest a potential neuroprotective activity of apigenin.”

 

Antidepressant-like behavioral and neurochemical effects of the citrus-associated chemical apigenin

These data suggest that apigenin inhibits glutamatergic synaptic transmission in cultured rat hippocampal neurons by inhibiting AMPA-, NMDA-, and depolarization-induced Ca2+ influx as well as metabotropic glutamate receptor-induced release of Ca2+ from IP3-sensitive intracellular stores and Ca2+-induced Ca2+ release from ryanodine-sensitive stores. However, it has not been studied in the present study whether apigenin affects the release of glutamate in the presynaptic sites, although apigenin inhibited the high K+-induced [Ca2+]i increase in the soma.

Apigenin has neuroprotective effects against oxidative stress-induced cell death in SH-SY5Y cells (Wang et al, 2001), or glutamate-induced neurotoxicity in cultured cortical neurons (Losi et al, 2004). Our results showed that apigenin inhibits glutamate-induced calcium signaling. These results suggest a possibility that inhibitory effects of apigenin on glutamate-induced calcium signaling can partly be due to the neuroprotection against neuronal cell death, demonstrating a possibility that apigenin might be used as a neuroprotective agent against glutamate-induced neurotoxicity, partly through inhibition of calcium signaling.

 

Protection of apigenin against excitotoxicity by anti-oxidative effects

Apigenin (5,7,4′-trihydroxyflavone) is a principal ingredient of Cirsium japonicum. These experiments were performed to determine whether apigenin has neuroprotective effects against kainic acid (KA)-induced excitotoxicity in vitro and in vivo. Intraperitoneal (i.p.) administration of apigenin (25, 50 mg/kg) decreased the seizure scores induced by KA injection (40 mg/kg, i.p.) in mice. In addition, the convulsion onset time was significantly delayed by apigenin administration.

Moreover, we found that apigenin blocked KA-induced seizure-form electroencephalogram (EEG) discharge activity in the brain cortex. In hippocampal cells, apigenin inhibited KA-induced excitotoxicity in a dose-dependent manner as measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.

To study the possible mechanisms underlying the in vitro neuroprotective effects of apigenin against KA-induced cytotoxicity, we also examined the effect of apigenin on intracellular reactive oxygen species (ROS) elevations in cultured hippocampal neurons and found that apigenin treatment dose-dependently inhibited intracellular ROS elevation.

The remarkable reduction of glutathione (GSH) levels induced by KA in hippocampal tissues was reversed by apigenin in a dose-dependent manner. In addition, similar results were obtained after pretreatment with free radical scavengers such as trolox and dimethylthiourea (DMTU). Finally, after confirming the protective effect of apigenin in hippocampal CA3 region, we found apigenin is an active compound in KA-induced neuroprotection. These results collectively indicate that apigenin alleviates KA-induced excitotoxicity by quenching ROS as well as inhibiting GSH depletion in hippocampal neurons.

 

Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease

“Androgen-inducible transforming growth factor β (TGF-β1) derived from dermal papilla cells (DPCs) is a catagen inducer that mediates hair growth suppression in androgenetic alopecia (AGA). In this study, a cell-based assay system was developed to monitor TGF-β1 promoter activity and then used to evaluate the effects of activated TGF-β1 promoter in human epidermal keratinocytes (HaCaT). To accomplish this, a pMetLuc-TGF-β1 promoter plasmid that expresses the luciferase reporter gene in response to TGF-β1 promoter activity was constructed. Treatment of HaCaT with dihydrotestosterone, which is known to be a primary factor of AGA, resulted in a concentration-dependent increase in TGF-β1 promoter activity.

 

However, treatment of HaCaT with the TGF-β1 inhibitor, curcumin, resulted in a concentration-dependant decrease in TGF-β1 expression. Subsequent use of this assay system to screen TGF-β1 revealed that HaCaT that were treated with apigenin showed decreased levels of TGF-β1 expression. In addition, treatment with apigenin also significantly increased the proliferation of both SV40T-DPCs (human DPCs) and HaCaT cells. Furthermore, apigenin stimulated the elongation of hair follicles in a rat vibrissa hair follicle organ culture. Taken together, these findings suggest that apigenin, which is known to have antioxidant, anti-inflammatory, and anti-tumor properties, stimulates hair growth through downregulation of the TGF-β1 gene.”

 

LONG HALF LIFE builds up over time. “Blood kinetics showed a high elimination half-time (91.8 hr), a distribution volume of 259 mL, and a plasmatic clearance of 1.95 mL/hr. All of the parameters calculated from these experiments suggested a slow metabolism of apigenin, with a slow absorption and a slow elimination phase. Thus, a possible accumulation of this flavonoid in the body can be hypothesized.”

 

ADDITIONAL SCIENTIFIC STUDIES ON APIGENIN

1. Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1beta and tumor necrosis factor-alpha genes in J774. 2 macrophages.
2. Topical apigenin improves epidermal permeability barrier homoeostasis in normal murine skin by divergent mechanisms
3. Apigenin and cancer chemoprevention: progress, potential and promise
4. An increase in the luteolin: apigenin ratio in Marchantia polymorpha on UV-B enhancement
5. Anti-inflammatory effects of apigenin on nicotine-and lipopolysaccharide-stimulated human periodontal ligament cells via heme oxygenase-1
6. Metabolism of apigenin by rat liver phase I and phase II enzymes and by isolated perfused rat liver
7. Apigenin: a promising molecule for cancer prevention
8. Dietary apigenin reduces LPS‐induced expression of miR‐155 restoring immune balance during inflammation
9. The Immune-modulatory and Anti-carcinogenic Mechanisms of the Flavonoid Apigenin
10. Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets
11. Inhibition of proteasome activity by the dietary flavonoid apigenin is associated with growth inhibition in cultured breast cancer cells and xenografts
12. Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways
13. Apigenin inhibits TGF-β1 induced fibroblast-to-myofibroblast transition in human lung fibroblast populations
14. Metabolism of flavonoids via enteric recycling: mechanistic studies of disposition of apigenin in the Caco-2 cell culture model
15. Apigenin inhibits the self-renewal capacity of human ovarian cancer SKOV3‑derived sphere-forming cells
16. Potential synergy of phytochemicals in cancer prevention: mechanism of action
17. Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer
18. Apigenin and its impact on gastrointestinal cancers
19. Targeting the PI3K/Akt/mTOR axis by apigenin for cancer prevention
20. Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-α-dependent and estrogen receptor-α-independent mechanisms
21. Apigenin suppresses cancer cell growth through ERβ
22. Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells
23. Protoapigenone, a natural derivative of apigenin, induces mitogen-activated protein kinase-dependent apoptosis in human breast cancer cells
24. Autophagy inhibition enhances apigenin-induced apoptosis in human breast cancer cells
25. Apigenin, a dietary flavonoid, inhibits proliferation of human bladder cancer T-24 cells via blocking cell cycle progression and inducing apoptosis
26. Phytoestrogens: potential benefits and implications for breast cancer survivors
27. Plant-derived flavone Apigenin: the small-molecule with promising activity against therapeutically resistant prostate cancer
28. Apigenin and breast cancers: from chemistry to medicine
29. Flavonoid apigenin modified gene expression associated with inflammation and cancer and induced apoptosis in human pancreatic cancer cells
30. Role of apigenin in cancer prevention via the induction of apoptosis and autophagy
31. Combined with Apigenin Synergistically Induced Apoptosis and Inhibited Migration in Human Breast and Liver Cancer
32. Apigenin and cancer chemoprevention
33. Protective effect of apigenin on radiation-induced chromosomal damage in human lymphocytes
34. Suppression of rat and human androgen biosynthetic enzymes by apigenin: possible use for the treatment of prostate cancer
35. Resveratrol, piperine and apigenin differ in their NADPH-oxidase inhibitory and reactive oxygen species-scavenging properties
36. Apigenin augments the growth inhibitory effects of doxorubicin in breast cancer cells derived from African American patients
37. Additive and synergistic effect of phytochemicals in prevention of oral cancer
38. Oxidative stress triggered by Apigenin induces apoptosis in a comprehensive panel of human cervical cancer-derived cell lines
39. Modulation of thyroidal radioiodide uptake by oncological pipeline inhibitors and Apigenin
40. Effect of dietary apigenin on colonic ornithine decarboxylase activity, aberrant crypt foci formation, and tumorigenesis in different experimental models
41. Dietary apigenin potentiates the inhibitory effect of interferon-α on cancer cell viability through inhibition of 26S proteasome-mediated interferon receptor
42. Anti-mutagenic and pro-apoptotic effects of apigenin on human chronic lymphocytic leukemia cells
43. Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest
44. Bioinformatics and in vitro experimental analyses identify the selective therapeutic potential of interferon gamma and apigenin against cervical squamous cell
45. Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention
46. Apigenin for chemoprevention, and chemotherapy combined with therapeutic reagents
47. Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats
48. Chlorpromazine and apigenin reduce adenovirus replication and decrease replication associated toxicity
49. Apigenin inhibits HeLa sphere‑forming cells through inactivation of casein kinase 2α
50. Synthesis, characterization and free radical scavenging activity of apigenin with or without magnesium (II)
51. Actions of the Dietary Flavone Apigenin in the Context of Human Colorectal Cancer
52. INHIBITORY EFFECTS OF APIGENIN ON MAMMALIAN DNAPOLYMERASE AND PROLIFERATION OF HUMAN CANCER CELLS
53. Apigenin stabilized gold nanoparticles increased radiation therapy efficiency in lung cancer cells
54. ROLE OF APIGENIN IN CANCER PREVENTION
55. The Flavonoid Apigenin Inhibits Inducible Programmed Death Ligand 1 Expression by Breast Cancer Cells
56. Apigenin-ask a busy flavone!
57. The flavonoids apigenin and luteolin suppress ultraviolet A-induced matrix metalloproteinase-1 expression via MAPKs and AP-1-dependent signaling in HaCaT cells
58. Citrus flavonoids luteolin, apigenin, and quercetin inhibit glycogen synthase kinase-3β enzymatic activity by lowering the interaction energy within the binding cavity
59. Apigenin: chemopreventive and chemotherapeutic potential for progestin-dependent breast cancer
60. Degradable poly (apigenin) polymer inhibits tumor cell adhesion to vascular endothelial cells
61. Apigenin in combination with Akt inhibition significantly enhances thyrotropin-stimulated radioiodide accumulation in thyroid cells
62. Effects of apigenin, lycopene and astaxanthin on 7β-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells
63. Apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of PKCδ-Y311
64. Apigenin prevents development of medroxyprogesterone acetate-accelerated 7, 12-dimethylbenz (a) anthracene-induced mammary tumors in Sprague-Dawley rats
65. The dietary flavones apigenin and luteolin impair smooth muscle cell migration and VEGF expression through inhibition of PDGFR-β phosphorylation
66. The natural flavonoid apigenin suppresses Th1-and Th2-related chemokine production by human monocyte THP-1 cells through mitogen-activated protein kinase
67. Apigenin (4 ‘, 5, 7‐trihydroxyflavone) regulates hyperglycaemia, thyroid dysfunction and lipid peroxidation in alloxan‐induced diabetic mice
68. The role of apigenin in an experimental model of acute pancreatitis
69. Protection by chrysin, apigenin, and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1 and glutamate cysteine
70. Specific role of oxidized species in the bioactivity of two antioxidants: apigenin and 20-hydroxyecdysone
71. Curcumin and Apigenin–novel and promising therapeutics against chronic neuroinflammation in Alzheimer’s disease
72. Mechanism of apoptosis induced by apigenin in HepG2 human hepatoma cells: involvement of reactive oxygen species generated by NADPH oxidase
73. Apigenin: The Anxiolytic Constituent of Turnera aphrodisiaca.
74. Anti-inflammatory effect of apigenin-7-neohesperidoside (rhoifolin) in carrageenin-induced rat oedema model
75. Apigenin inhibits TGF-β1-induced proliferation and migration of airway smooth muscle cells
76. Effects of the vegetable polyphenols epigallocatechin-3-gallate, luteolin, apigenin, myricetin, quercetin, and cyanidin in primary cultures of human retinal
77. Evaluation of hepatic clearance and drug-drug interactions of luteolin and apigenin by using primary cultured rat hepatocytes
78. Pharmacokinetic study of luteolin, apigenin, chrysoeriol and diosmetin after oral administration of Flos Chrysanthemi extract in rats
79. DNA adducts with antioxidant flavonoids: morin, apigenin, and naringin
80. Apigenin attenuates neointima formation via suppression of vascular smooth muscle cell phenotypic transformation
81. Neuroprotective and neurotrophic effects of Apigenin and Luteolin in MPTP induced parkinsonism in mice
82. Preparation of apigenin nanocrystals using supercritical antisolvent process for dissolution and bioavailability enhancement
83. Apigenin as neuroprotective agent: Of mice and men
84. The estrogenic effects of apigenin, phloretin and myricetin based on uterotrophic assay in immature Wistar albino rats
85. Apigenin inhibits C5a-induced proliferation of human nasopharyngeal carcinoma cells through down-regulation of C5aR
86. Antiadipogenic effect of dietary apigenin through activation of AMPK in 3T3-L1 cells
87. Apigenin in the regulation of cholesterol metabolism and protection of blood vessels
88. Efflux transport of chrysin and apigenin sulfates in HEK293 cells overexpressing SULT1A3: The role of multidrug resistance-associated protein 4 (MRP4/ABCC4)
89. Apigenin inhibits platelet adhesion and thrombus formation and synergizes with aspirin in the suppression of the arachidonic acid pathway
90. Synergistic activity and mechanism of action of ceftazidime and apigenin combination against ceftazidime-resistant Enterobacter cloacae
91. Inhibition of superoxide anion-mediated impairment of endothelium by treatment with luteolin and apigenin in rat mesenteric artery
92. Plant flavone apigenin binds to nucleic acid bases and reduces oxidative DNA damage in prostate epithelial cells
93. Anti-mutagenic and pro-apoptotic effects of apigenin on human chronic lymphocytic leukemia cells
94. Enhanced action of apigenin and naringenin combination on estrogen receptor activation in non-malignant colonocytes
95. Recovery of chicken growth plate by heat-shock protein 90 inhibitors epigallocatechin-3-gallate and apigenin in thiram-induced tibial dyschondroplasia
96. Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease
97. Effects of friedelin on the intestinal permeability and bioavailability of apigenin
98. Microencapsulation of plant extracts rich in apigenin to be used as chemopreventive agents in functional foods
99. 5‐Fluorouracil combined with apigenin enhances anticancer activity through mitochondrial membrane potential (ΔΨm)‐mediated apoptosis in hepatocellular
100. Calcium-and phosphatidylinositol 3-kinase/Akt-dependent activation of endothelial nitric oxide synthase by apigenin
101. Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome
102. APIGENIN CAUSES BIOCHEMICAL MODULATION, GLUT4 AND CD38 ALTERATIONS TO IMPROVE DIABETES AND  TO PROTECT DAMAGES OF SOME VITAL ORGANS IN  EXPERIMENTAL DIABETES
103. Inhibition of CK2α and PI3K/Akt synergistically induces apoptosis of CD34+ CD38− leukaemia cells while sparing haematopoietic stem cells
104. Flavonoid Apigenin Is an Inhibitor of the NAD+ ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome
105. Dysregulation of the Nadase CD38 impairs articular chondrocyte homeostasis
106. Role of CD38 expression in diagnosis and pathogenesis of chronic lymphocytic leukemia and its potential as therapeutic target
107. Effects of apigenin on steroidogenesis and steroidogenic acute regulatory gene expression in mouse Leydig cells
108. The Roles of Apigenin on Leydig Cells in Testes of Rats [J]
109. Investigation of testosterone, androstenone, and estradiol metabolism in HepG2 cells and primary culture pig hepatocytes and their effects on 17βHSD7 gene
110. Effects of apigenin on scrotal heat-induced damage in the mice testis
111. Natural Compounds to Counteract Testosterone Depletion in Aging
112. Apigenin inhibits rat neurosteroidogenic 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase
113. The Pharmacokinetics of Raloxifene and Its Interaction with Apigenin in Rat
114. Dietary supplements of soya flour lower serum testosterone concentrations and improve markers of oxidative stress in men
115. Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt
116. Signal pathways involved in apigenin inhibition of growth and induction of apoptosis of human anaplastic thyroid cancer cells (ARO)
117. Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin
118. Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer
119. Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human
120. Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells
121. Stimulatory effect of genistein and apigenin on the growth of breast cancer cells correlates with their ability to activate ER alpha
122. Degradation of HER2/neu by apigenin induces apoptosis through cytochrome c release and caspase‐3 activation in HER2/neu‐overexpressing breast cancer cells
123. Activation of PPARγ by a natural flavonoid modulator, apigenin ameliorates obesity-related inflammation via regulation of macrophage polarization
124. Apigenin ameliorates dyslipidemia, hepatic steatosis and insulin resistance by modulating metabolic and transcriptional profiles in the liver of high-fat diet
125. Apigenin isolated from Daphne genkwa Siebold et Zucc. inhibits 3T3-L1 preadipocyte differentiation through a modulation of mitotic clonal expansion
126. Apigenin isolated from the seeds of Perilla frutescens britton var crispa (Benth.) inhibits food intake in C57BL/6J mice
127. Synergistic interactions of apigenin, naringin, quercetin and emodin on inhibition of 3T3-L1 preadipocyte differentiation and pancreas lipase activity
128. Apigenin and quercetin ameliorate mitochondrial alterations by tunicamycin-induced ER stress in 3T3-L1 adipocytes
129. Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation
130. Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential
131. Inhibitory activity of phenolic compounds from extra virgin olive oils on the enzymes involved in diabetes, obesity and hypertension
132. Studies on mechanistic role of natural bioactive compounds in the management of obesity an overview
133. The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity
134. Comparative study of the binding of 3 flavonoids to the fat mass and obesity‐associated protein by spectroscopy and molecular modeling
135. Effect of Apigenin on the Proliferation and Differentiation of 3T3-L1 Preadipocytes [J]
136. Phenolic compounds apigenin, hesperidin and kaempferol reduce in vitro lipid accumulation in human adipocytes
137. Apigenin attenuates diabetes-associated cognitive decline in rats via suppressing oxidative stress and nitric oxide synthase pathway
138. Antioxidant and protective effects of major flavonoids from Teucrium polium on β-cell destruction in a model of streptozotocin-induced diabetes
139. Apigenin Attenuates 2-Deoxy-D-ribose-Induced Oxidative Cell Damage in HIT-T15 Pancreatic β-Cells
140. Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study
141. Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats
142. The protective effect of apigenin on myocardial injury in diabetic rats mediating activation of the PPAR-γ pathway
143. Mechanism of action of the stimulatory effect of apigenin-6-C-(2 ″-O-α-l-rhamnopyranosyl)-β-l-fucopyranoside on 14C-glucose uptake
144. The flavones apigenin and luteolin induce FOXO1 translocation but inhibit gluconeogenic and lipogenic gene expression in human cells
145. Comparative investigation of in vitro biotransformation of 14 components in Ginkgo biloba extract in normal, diabetes and diabetic nephropathy rat intestinal bacteria
146. Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet/streptozotocin-induced diabetes in mice
147. Stimulatory effect of apigenin-6-C-β-L-fucopyranoside on insulin secretion and glycogen synthesis
148. Apigenin restores normal vascular reactivity in diabetic rats via protein kinase C inhibition
149. Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways
150. Apigenin attenuates streptozotocin-induced pancreatic β cell damage by its protective effects on cellular antioxidant defense
151. Dietary flavonoid apigenin inhibits high glucose and tumor necrosis factor α-induced adhesion molecule expression in human endothelial cells
152. Apigenin alleviates STZ-induced diabetic cardiomyopathy
153. Anti-hyperglycemic action of apigenin-6-C-β-fucopyranoside from Averrhoa carambola
154. Effects of C-glycosylation on anti-diabetic, anti-Alzheimer’s disease and anti-inflammatory potential of apigenin
155. A study on the inhibitory potential of DPP-IV enzyme by apigenin through in silico and in vivo approaches
156. Pancreatic Β-cell protective effect of rutin and apigenin isolated from Teucrium polium
157. Saturin-effective vegetative remedy in treatment of type 2 diabetes mellitus
158. Role of various flavonoids: hypotheses on novel approach to treat diabetes
159. Apigenin: A methanol fraction component of Newbouldia laevis leaf, as a potential antidiabetic agent
160. Synthesis and α-glucosidase inhibitory activity of chrysin, diosmetin, apigenin, and luteolin derivatives
161. Synthesis, nitric oxide release, and α-glucosidase inhibition of nitric oxide donating apigenin and chrysin derivatives
162. Apigenin inhibits mTORC2 through down-regulation of RICTOR expression in colorectal cancer cells
163. Inhibitory effect of polyphenolic–rich extract from Cola nitida (Kolanut) seed on key enzyme linked to type 2 diabetes
164. Apigenin and naringenin ameliorate PKCβII-associated endothelial dysfunction via regulating ROS/caspase-3
165. GW27-e0367 Apigenin attenuates the cardiac remodeling in experimental diabetic cardiomyopathy
166. 39 Studies on the antidiabetic activity of apigenin in mice with streptozotocin-induced diabetes
167. Apigenin attenuates diabetes-associated cognitive decline in rats via suppressing oxidative stress, nitric oxide synthase and anti-apoptotic pathway
168. Anti-degenerative effect of Apigenin, Luteolin and Quercetin on human keratinocyte and chondrocyte cultures: SAR evaluation
169. Su1790 Apigenin Analogs Effectively Suppress Pancreatic Stellate Cell Proliferation and Induce Apoptosis
170. Apigenin inhibition on alpha glucosidase in mice intestinal
171. Apigenin inhibits tumor necrosis factor alpha plus high glucose-induced LOX-1 expression in human endothelial cells
172. Apigenin induces apoptosis in Hep G2 cells: possible role of TNF-α and IFN-γ
173. Apigenin: A current review on its beneficial biological activities
174. Improvement of Anti-Cancer Activity through the Structural Modification of Gamma-Irradiated Apigenin in H1975 Human Non-Small Lung Cell
175. Flavonoid apigenin inhibits lipopolysaccharide-induced inflammatory response through multiple mechanisms in macrophages
176. Apigenin inhibits endothelial‐cell proliferation in G2/M phase whereas it stimulates smooth‐muscle cells by inhibiting P21 and P27 expression
177. Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships.
178. Effects of apigenin on the serum-and platelet derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells
179. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects
180. Apigenin inhibits cell migration through MAPK pathways in human bladder smooth muscle cells
181. Endothelium-dependent vasorelaxant and antiproliferative effects of apigenin
182. Vasodilatory action mechanisms of apigenin isolated from Apium graveolens in rat thoracic aorta
183. Inhibition of guinea pig intestinal peristalsis by the flavonoids quercetin, naringenin, apigenin and genistein
184. Apigenin decreases expression of the myofibroblast phenotype
185. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages
186. Apigenin inhibits tumor angiogenesis through decreasing HIF-1α and VEGF expression
187. Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy
188. A cell-based system for screening hair growth-promoting agents
189. Taken together, these findings suggest that APIGENIN, which is known to have antioxidant, anti-inflammatory, and anti-tumor properties, stimulates hair growth through downregulation of the TGF-beta1 gene.
190. Effects of seven pure flavonoids from mosses on germination and growth of Tortula muralis HEDW.(Bryophyta) and Raphanus sativus L.(Magnoliophyta)
191. Apigenin, a chemopreventive bioflavonoid, induces AMP‐activated protein kinase activation in human keratinocytes
192. Enhancement of p53 expression in keratinocytes by the bioflavonoid apigenin is associated with RNA‐binding protein HuR
193. The flavone apigenin blocks nuclear translocation of sterol regulatory element-binding protein-2 in the hepatic cells WRL-68
194. AMPK-mTOR axis as key target for chemoprevention of UV-induced skin cancer by the bioflavonoid apigenin
195. Apigenin and luteolin display differential hypocholesterolemic mechanisms in mice fed a high-fat diet
196. Apigenin-7-O-β-d-(-6 ″-p-coumaroyl)-glucopyranoside pretreatment attenuates myocardial ischemia/reperfusion injury via activating AMPK signaling
197. The flavone apigenin blocks SREBP-2 activation in hepatic cells
198. Apigenin Ameliorates the Obesity‐Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice
199. Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells
200. Reversal of Warburg effect by Apigenin and 5-Fluorouracil loaded dual drug liposomes result in enhanced colorectal chemotherapy
201. APIGENIN: a promising molecule for cancer prevention
202. APIGENIN and cancer chemoprevention: progress, potential and promise
203. APIGENIN and its impact on gastrointestinal cancers
204. APIGENIN suppresses cancer cell growth through ERβ
205. Measurement and correlation of solubilities of APIGENIN and APIGENIN 7-O-rhamnosylglucoside in seven solvents at different temperatures
206. Behavioral characterisation of the flavonoids APIGENIN and chrysin
207. Evaluation of properties of APIGENIN and [G-3H] APIGENIN and analytic method development
208. Flavonoids APIGENIN and quercetin inhibit melanoma growth and metastatic potential
209. Cytotoxicity of APIGENIN on leukemia cell lines: implications for prevention and therapy
210. Pharmacological profile of APIGENIN, a flavonoid isolated from Matricaria chamomilla
211. Cell‐cycle arrest at G2/M and growth inhibition by APIGENIN in human colon carcinoma cell lines
212. Bioavailability of APIGENIN from apiin-rich parsley in humans
213. Influence of APIGENIN on gtf Gene Expression in Streptococcus mutans UA159
214. APIGENIN induced apoptosis through p53-dependent pathway in human cervical carcinoma cells
215. Anti-mutagenesis and anti-promotion by APIGENIN, robinetin and indole-3-carbinol
216. APIGENIN inhibits tumor angiogenesis through decreasing HIF-1α and VEGF expression
217. Protective role of APIGENIN on the status of lipid peroxidation and antioxidant defense against hepatocarcinogenesis in Wistar albino rats
218. Anti-proliferative effect of APIGENIN and its apoptotic induction in human Hep G2 cells
219. Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of APIGENIN in normal versus human prostate carcinoma cells
220. APIGENIN inhibits VEGF and HIF‐1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways
221. Synergistic effects of APIGENIN and paclitaxel on apoptosis of cancer cells
222. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by APIGENIN and related flavonoids in mouse macrophages
223. APIGENIN-induced-apoptosis is mediated by the activation of PKCδ and caspases in leukemia cells
224. Metabolism of APIGENIN and related compounds in the rat. Metabolite formation in vivo and by the intestinal microflora in vitro
225. Pharmacokinetics and metabolism of APIGENIN in female and male rats after a single oral administration
226. APIGENIN acts on the tumor cell invasion process and regulates protease production
227. Neuroprotective, anti-amyloidogenic and neurotrophic effects of APIGENIN in an Alzheimer’s disease mouse model
228. Metabolism of APIGENIN by rat liver phase I and phase II enzymes and by isolated perfused rat liver
229. Inhibitory effect of APIGENIN, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice
230. Induction of p21/WAF1 and G1 cell‐cycle arrest by the chemopreventive agent APIGENIN
231. Effects of the flavonoids quercetin and APIGENIN on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study
232. APIGENIN, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects
233. The chemopreventive flavonoid APIGENIN induces G2/M arrest in keratinocytes
234. APIGENIN induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo
235. Antiadipogenic effect of dietary APIGENIN through activation of AMPK in 3T3-L1 cells
236. Signal pathways involved in APIGENIN inhibition of growth and induction of apoptosis of human anaplastic thyroid cancer cells (ARO).
237. Vasodilatory action mechanisms of APIGENIN isolated from Apium graveolens in rat thoracic aorta
238. Anti-hyperglycemic action of APIGENIN-6-C-β-fucopyranoside from Averrhoa carambola
239. APIGENIN inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer
240. Biopharmaceutics classification and intestinal absorption study of APIGENIN
241. Enhanced anti-tumor effect of combination therapy with gemcitabine and APIGENIN in pancreatic cancer
242. APIGENIN-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation
243. Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of APIGENIN human targets
244. APIGENIN inhibits hepatoma cell growth through alteration of gene expression patterns
245. Molecular targets for APIGENIN-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft
246. Endothelium-dependent vasorelaxant and antiproliferative effects of APIGENIN
247. Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by APIGENIN and tt-farnesol
248. Preparation and in vitro evaluation of APIGENIN-loaded polymeric micelles
249. APIGENIN induces cell cycle arrest and p21/WAF1 expression in a p53-independent pathway
250. Study of antioxidant effect of APIGENIN, luteolin and quercetin by DNA protective method.
251. Skin anti-inflammatory activity of APIGENIN-7-glucoside in rats.
252. Increase in wild-type p53 stability and transactivational activity by the chemopreventive agent APIGENIN in keratinocytes
253. APIGENIN blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-κB through the suppression of p65 …
254. APIGENIN inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest
255. Design and evaluation of a self-microemulsifying drug delivery system for APIGENIN
256. Antidepressant-like behavioral and neurochemical effects of the citrus-associated chemical APIGENIN
257. Production and characterization of antioxidant APIGENIN nanocrystals as a novel UV skin protective formulation
258. Targeting the PI3K/Akt/mTOR axis by APIGENIN for cancer prevention
259. Anti-inflammatory activity of structurally related flavonoids, APIGENIN, Luteolin and Fisetin
260. Protective effect of APIGENIN on radiation-induced chromosomal damage in human lymphocytes
261. Autophagy inhibition enhances APIGENIN-induced apoptosis in human breast cancer cells
262. Induction of apoptosis by APIGENIN and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells
263. Attenuation of osteoclastogenesis and osteoclast function by APIGENIN
264. Protection of APIGENIN against kainate-induced excitotoxicity by anti-oxidative effects
265. Study on interaction between APIGENIN and human serum albumin by spectroscopy and molecular modeling
266. Molecular mechanisms for APIGENIN‐induced cell‐cycle arrest and apoptosis of hormone refractory human prostate carcinoma DU145 cells
267. Effect of APIGENIN, kaempferol and resveratrol on the expression of interleukin-1beta and tumor necrosis factor-alpha genes in J774. 2 macrophages.
268. APIGENIN induces morphological differentiation and G2-M arrest in rat neuronal cells
269. APIGENIN (4 ‘, 5, 7-trihydroxyflavone) regulates hyperglycaemia, thyroid dysfunction and lipid peroxidation in alloxan-induced diabetic mice
270. Flavonoid (myricetin, quercetin, kaempferol, luteolin, and APIGENIN) content of edible tropical plants
271. Antigenotoxic effect of APIGENIN against anti-cancerous drugs
272. Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by APIGENIN and curcumin
273. An increase in the luteolin: APIGENIN ratio in Marchantia polymorpha on UV-B enhancement
274. APIGENIN inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells.
275. Structure, conformation, and electronic properties of APIGENIN, luteolin, and taxifolin antioxidants. A first principle theoretical study
276. APIGENIN modulates GABAergic and glutamatergic transmission in cultured cortical neurons
277. APIGENIN induces apoptosis through a mitochondria/caspase-pathway in human breast cancer MDA-MB-453 cells
278. APIGENIN suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF-1α protein
279. Flavonoid APIGENIN inhibits motility and invasiveness of carcinoma cells in vitro
280. APIGENIN inhibited migration and invasion of human ovarian cancer A2780 cells through focal adhesion kinase
281. Individual and interactive effects of APIGENIN analogs on G2/M cell-cycle arrest in human colon carcinoma cell lines
282. Anti-inflammatory mechanisms of APIGENIN: inhibition of cyclooxygenase-2 expression, adhesion of monocytes to human umbilical vein endothelial cells, and …
283. Metabolism of flavonoids via enteric recycling: mechanistic studies of disposition of APIGENIN in the Caco-2 cell culture model
284. Induction of caspase-dependent, p53-mediated apoptosis by APIGENIN in human neuroblastoma
285. APIGENIN prevents UVB-induced cyclooxygenase 2 expression: coupled mRNA stabilization and translational inhibition
286. Stimulatory effect of genistein and APIGENIN on the growth of breast cancer cells correlates with their ability to activate ER alpha
287. Antidepressant-like effects of APIGENIN and 2, 4, 5-trimethoxycinnamic acid from Perilla frutescens in the forced swimming test
288. The role of APIGENIN in an experimental model of acute pancreatitis
289. Stimulatory effect of APIGENIN-6-C-β-L-fucopyranoside on insulin secretion and glycogen synthesis
290. Mechanisms of APIGENIN-7-glucoside as a hepatoprotective agent
291. Protective effect of APIGENIN on ovariectomy-induced bone loss in rats
292. Molecular targets of APIGENIN in colorectal cancer cells: involvement of p21, NAG-1 and p53
293. APIGENIN-induced apoptosis in A375 and A549 cells through selective action and dysfunction of mitochondria
294. APIGENIN: The Anxiolytic Constituent of Turnera aphrodisiaca.
295. APIGENIN sensitizes colon cancer cells to antitumor activity of ABT-263
296. Use of APIGENIN from Cordia dichotoma in the treatment of colitis
297. Involvement of catalase in the apoptotic mechanism induced by APIGENIN in HepG2 human hepatoma cells
298. Evaluation of APIGENIN using in vitro cytochalasin blocked micronucleus assay
299. Absorption and Excretion of Luteolin and APIGENIN in Rats after Oral Administration of Chrysanthemum morifolium Extract
300. The chemopreventive bioflavonoid APIGENIN modulates signal transduction pathways in keratinocyte and colon carcinoma cell lines
301. Mechanism of action of the stimulatory effect of APIGENIN-6-C-(2 ″-O-α-l-rhamnopyranosyl)-β-l-fucopyranoside on 14C-glucose uptake
302. D-Alanine: D-alanine ligase as a new target for the flavonoids quercetin and APIGENIN
303. Acidichromism and ionochromism of luteolin and APIGENIN, the main components of the naturally occurring yellow weld: a spectrophotometric and fluorimetric study
304. Enzyme assisted extraction of luteolin and APIGENIN from pigeonpea [Cajanuscajan (L.) Millsp.] leaves
305. The bioavailability of APIGENIN-7-glucoside is influenced by human intestinal microbiota in rats
306. Synthesis and biological evaluation of APIGENIN derivatives as antibacterial and antiproliferative agents
307. A new cytotoxic acylated APIGENIN glucoside from Phyllanthus emblica L.
308. Plant flavonoid APIGENIN inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study
309. Blockade of β-catenin signaling by plant flavonoid APIGENIN suppresses prostate carcinogenesis in TRAMP mice
310. APIGENIN protects endothelium-dependent relaxation of rat aorta against oxidative stress
311. Effects of APIGENIN and tt‐farnesol on glucosyltransferase activity, biofilm viability and caries development in rats
312. APIGENIN inhibits the GLUT-1 glucose transporter and the phosphoinositide 3-kinase/Akt pathway in human pancreatic cancer cells
313. Attenuation of oxidative damage and inflammatory responses by APIGENIN given to mice after irradiation
314. APIGENIN induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt …
315. Isolation, identification and stability of acylated derivatives of APIGENIN 7-O-glucoside from chamomile (Chamomilla recutita [L.] Rauschert)
316. Evidence for activation of mutated p53 by APIGENIN in human pancreatic cancer
317. APIGENIN and tt-Farnesol with Fluoride Effects on S. mutans Biofilms and Dental Caries
318. APIGENIN inhibits immunostimulatory function of dendritic cells: Implication of immunotherapeutic adjuvant
319. APIGENIN-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human …
320. APIGENIN shows synergistic anticancer activity with curcumin by binding at different sites of tubulin
321. Antigenotoxicity, cytotoxicity, and apoptosis induction by APIGENIN, bisabolol, and protocatechuic acid
322. Keratinocyte proliferation, differentiation, and apoptosis—differential mechanisms of regulation by curcumin, EGCG and APIGENIN
323. Preparation of APIGENIN nanocrystals using supercritical antisolvent process for dissolution and bioavailability enhancement
324. Preliminary enrichment and separation of genistein and APIGENIN from extracts of pigeon pea roots by macroporous resins
325. Dietary flavonoid APIGENIN is a potential inducer of intracellular oxidative stress: the role in the interruptive apoptotic signal
326. Simultaneous determination of luteolin and APIGENIN in dog plasma by RP-HPLC
327. Evaluation of the effects of the flavonoid APIGENIN on apoptotic pathway gene expression on the colon cancer cell line (HT29)
328. APIGENIN inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells
329. In vitro anti-inflammatory effect of APIGENIN in the Helicobacter pylori-infected gastric adenocarcinoma cells
330. Studies on a novel p-coumaroyl glucoside of APIGENIN and on other flavonoids isolated from patchouli (Labiatae)
331. APIGENIN down-regulates the hypoxia response genes: HIF-1α, GLUT-1, and VEGF in human pancreatic cancer cells
332. APIGENIN induces apoptosis in Hep G2 cells: possible role of TNF-α and IFN-γ
333. APIGENIN and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression
334. APIGENIN inhibits the production of NO and PGE2 in microglia and inhibits neuronal cell death in a middle cerebral artery occlusion-induced focal ischemia mice model
335. Interactions between sulforaphane and APIGENIN in the induction of UGT1A1 and GSTA1 in CaCo-2 cells
336. Absorption and emission of the APIGENIN and luteolin flavonoids: A TDDFT investigation
337. APIGENIN and related compounds stimulate adult neurogenesis: Mars, Inc., the Salk Institute for Biological Studies: WO2008147483
338. Quercetin, luteolin, APIGENIN and kaempferol contents of some foods
339. Influence of the flavonoids APIGENIN, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1
340. The dietary flavonoids APIGENIN and (−)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABAA …
341. APIGENIN suppresses insulin‐like growth factor I receptor signaling in human prostate cancer: An in vitro and in vivo study
342. The dietary flavonoid APIGENIN sensitizes malignant tumor cells to tumor necrosis factor–related apoptosis-inducing ligand
343. An APIGENIN-Derived Xanthine Oxidase Inhibitor from Palhinhaea cernua
344. APIGENIN attenuates copper-mediated β-amyloid neurotoxicity through antioxidation, mitochondrion protection and MAPK signal inactivation in an AD cell model
345. APIGENIN decreases cell viability and telomerase activity in human leukemia cell lines
346. APIGENIN inhibits release of inflammatory mediators by blocking the NF-κB activation pathways in the HMC-1 cells
347. APIGENIN inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-α-dependent and estrogen receptor-α-independent mechanisms
348. APIGENIN alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin
349. Src kinase is a direct target of APIGENIN against UVB-induced skin inflammation
350. Decreased pro-inflammatory cytokine production by LPS-stimulated PBMC upon in vitro incubation with the flavonoids APIGENIN, luteolin or chrysin, due to selective …
351. Plant flavone APIGENIN inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: in vitro and in vivo study
352. APIGENIN induces apoptosis in human lung cancer H460 cells through caspase-and mitochondria-dependent pathways
353. Raman and surface-enhanced Raman spectra of chrysin, APIGENIN and luteolin
354. APIGENIN inhibits proliferation of ovarian cancer A2780 cells through Id1
355. The flavonoid APIGENIN improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice
356. APIGENIN up-regulates transgelin and inhibits invasion and migration of colorectal cancer through decreased phosphorylation of AKT
357. APIGENIN induces caspase-dependent apoptosis in human lung cancer A549 cells through Bax-and Bcl-2-triggered mitochondrial pathway
358. Acute exposure of APIGENIN induces hepatotoxicity in Swiss mice
359. Peroxidative metabolism of APIGENIN and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation
360. Reinvestigation of the structural assignment of signals in the 1H and 13C NMR spectra of the flavone APIGENIN
361. APIGENIN and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats
362. Flavonoid APIGENIN is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome
363. Synergistic activity and mechanism of action of ceftazidime and APIGENIN combination against ceftazidime-resistant Enterobacter cloacae
364. APIGENIN inhibits oxidative stress‐induced macromolecular damage in N‐nitrosodiethylamine (NDEA)‐induced hepatocellular carcinogenesis in Wistar albino rats
365. Genotoxicities of nitropyrenes and their modulation by APIGENIN, tannic acid, ellagic acid and indole-3-carbinol in the Salmonella and CHO systems
366. Inhibition of proteasome activity by the dietary flavonoid APIGENIN is associated with growth inhibition in cultured breast cancer cells and xenografts
367. APIGENIN inhibits platelet adhesion and thrombus formation and synergizes with aspirin in the suppression of the arachidonic acid pathway
368. Enzymatic synthesis of APIGENIN glucosides by glucosyltransferase (YjiC) from Bacillus licheniformis DSM 13
369. APIGENIN causes G2/M arrest associated with the modulation of p21Cip1 and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 …
370. The chemopreventive bioflavonoid APIGENIN inhibits prostate cancer cell motility through the focal adhesion kinase/Src signaling mechanism
371. Acylated APIGENIN glycosides from alfalfa (Medicago sativa L.) var. Artal
372. Oral administration of APIGENIN inhibits metastasis through AKT/P70S6K1/MMP-9 pathway in orthotopic ovarian tumor model
373. APIGENIN-induced suicidal erythrocyte death
374. Mechanism of apoptosis induced by APIGENIN in HepG2 human hepatoma cells: involvement of reactive oxygen species generated by NADPH oxidase
375. APIGENIN inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90
376. Topical APIGENIN improves epidermal permeability barrier homoeostasis in normal murine skin by divergent mechanisms
377. Anti-inflammatory effects of APIGENIN on nicotine-and lipopolysaccharide-stimulated human periodontal ligament cells via heme oxygenase-1
378. DNA adducts with antioxidant flavonoids: morin, APIGENIN, and naringin
379. APIGENIN Inhibits Tumor Necrosis Factor-Induced Intercellular Adhesion Molecule-1 Upregulation In Vivo
380. Flavonoids such as Luteolin, Fisetin and APIGENIN Are Inhibitors of Interleukin-4 and Interleukin-13 Production by ActivatedHuman Basophils
381. APIGENIN, a chemopreventive bioflavonoid, induces AMP‐activated protein kinase activation in human keratinocytes
382. APIGENIN 7-glucoside and its 2 ″-and 6 ″-acetates from ligulate flowers of Matricaria chamomilla
383. A comparative DFT study on the antioxidant activity of APIGENIN and scutellarein flavonoid compounds
384. APIGENIN inhibits allergen-induced airway inflammation and switches immune response in a murine model of asthma
385. APIGENIN protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis
386. APIGENIN impairs oral squamous cell carcinoma growth in vitro inducing cell cycle arrest and apoptosis
387. A mechanism of APIGENIN-induced apoptosis is potentially related to anti-angiogenesis and anti-migration in human hepatocellular carcinoma cells
388. Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents APIGENIN (chamomile), ginsenoside Rb1 …
389. Combination of APIGENIN treatment with therapeutic HPV DNA vaccination generates enhanced therapeutic antitumor effects
390. Degradation of HER2/neu by APIGENIN induces apoptosis through cytochrome c release and caspase-3 activation in HER2/neu-overexpressing breast cancer …
391. APIGENIN, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells
392. The effects of APIGENIN‐7‐O‐β‐d‐glucuronopyranoside on reflux oesophagitis and gastritis in rats
393. The flavones luteolin and APIGENIN inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells
394. FTIR, 1H NMR and EPR spectroscopy studies on the interaction of flavone APIGENIN with dipalmitoylphosphatidylcholine liposomes
395. Chemoprotective effect of plant phenolics against anthracycline‐induced toxicity on rat cardiomyocytes. Part III. APIGENIN, baicalelin, kaempherol, luteolin and …
396. Ibuprofen and APIGENIN induce apoptosis and cell cycle arrest in activated microglia
397. Enhancement of UVB-induced apoptosis by APIGENIN in human keratinocytes and organotypic keratinocyte cultures
398. Effects of chrysin, APIGENIN, genistein and their homoleptic copper (II) complexes on the growth and metastatic potential of cancer cells
399. Cytotoxic APIGENIN Derivatives from Chrysopogon aciculatis
400. Inhibitions of protein kinase C and proto-oncogene expressions in NIH 3T3 cells by APIGENIN
401. Total synthesis of APIGENIN
402. Conformational Changes of APIGENIN 7‐O‐(6‐O‐malonylglucoside), a Vacuolar Pigment from Parsley, with Solvent Composition and Proton Concentration
403. Topical APIGENIN alleviates cutaneous inflammation in murine models
404. APIGENIN promotes apoptosis, inhibits invasion and induces cell cycle arrest of T24 human bladder cancer cells
405. The flavonoids APIGENIN and luteolin suppress ultraviolet A-induced matrix metalloproteinase-1 expression via MAPKs and AP-1-dependent signaling in HaCaT cells
406. APIGENIN sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway
407. APIGENIN induces apoptosis and blocks growth of medroxyprogesterone acetate-dependent BT-474 xenograft tumors
408. Suppression of constitutive and tumor necrosis factor α-induced nuclear factor (NF)-κB activation and induction of apoptosis by APIGENIN in human prostate carcinoma …
409. APIGENIN protects endothelial cells from lipopolysaccharide (LPS)-induced inflammation by decreasing caspase-3 activation and modulating mitochondrial function
410. APIGENIN induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells
411. APIGENIN sensitizes prostate cancer cells to Apo2L/TRAIL by targeting adenine nucleotide translocase-2
412. APIGENIN induces apoptosis via tumor necrosis factor receptor-and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to …
413. Synthesis, cytotoxic activity, and DNA binding properties of copper (II) complexes with hesperetin, naringenin, and APIGENIN
414. The flavonoid APIGENIN protects brain neurovascular coupling against amyloid-β 25-35-induced toxicity in mice
415. Interactions between dietary flavonoids APIGENIN or luteolin and chemotherapeutic drugs to potentiate anti-proliferative effect on human pancreatic cancer cells, in vitro
416. APIGENIN protects ovalbumin-induced asthma through the regulation of Th17 cells
417. APIGENIN inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cδ Tyr311
418. Characteristics of the isomeric flavonoids APIGENIN and genistein binding to hemoglobin by spectroscopic methods
419. APIGENIN, a dietary antioxidant, modulates gamma radiation-induced oxidative damages in human peripheral blood lymphocytes
420. Flavonoids, APIGENIN and icariin exert potent melanogenic activities in murine B16 melanoma cells
421. Protective effect of APIGENIN on mouse acute liver injury induced by acetaminophen is associated with increment of hepatic glutathione reductase activity
422. Protection by chrysin, APIGENIN, and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1 and glutamate cysteine …
423. APIGENIN, a plant‐derived flavone, activates transient receptor potential vanilloid 4 cation channel
424. Pharmacokinetic study of luteolin, APIGENIN, chrysoeriol and diosmetin after oral administration of Flos Chrysanthemi extract in rats
425. Structural determinants for activation and block of CFTR-mediated chloride currents by APIGENIN
426. Preparation and in vitro evaluation of APIGENIN loaded lipid nanocapsules
427. Differential modulation of cyclooxygenase-mediated prostaglandin production by the putative cancer chemopreventive flavonoids tricin, APIGENIN and quercetin
428. APIGENIN-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes
429. Inhibitory effects of APIGENIN on the growth of gastric carcinoma SGC-7901 cells
430. APIGENIN attenuates insulin-like growth factor-I signaling in an autochthonous mouse prostate cancer model
431. Apoptotic effects of genistein, biochanin-A and APIGENIN on LNCaP and PC-3 cells by p21 through transcriptional inhibition of polo-like kinase-1
432. Spectroscopic studies on the interaction of bovine serum albumin with surfactants and APIGENIN
433. Green, yellow and red emitting CdTe QDs decreased the affinities of APIGENIN and luteolin for human serum albumin in vitro
434. Tissue distribution in mice and metabolism in murine and human liver of APIGENIN and tricin, flavones with putative cancer chemopreventive properties
435. APIGENIN affects leptin/leptin receptor pathway and induces cell apoptosis in lung adenocarcinoma cell line
436. Overexpression of the Saussurea medusa chalcone isomerase gene in S. involucrata hairy root cultures enhances their biosynthesis of APIGENIN
437. Reversion of vH-ras-trasformed NIH 3T3 cells by APIGENIN through inhibiting mitogen-activated protein kinase and its downstream oncogenes
438. Prenylation enhances cytotoxicity of APIGENIN and liquiritigenin in rat H4IIE hepatoma and C6 glioma cells
439. In vivo and in vitro percutaneous absorption of cancer preventive flavonoid APIGENIN in different vehicles in mouse skin
440. Dietary phytophenols curcumin, naringenin and APIGENIN reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and …
441. APIGENIN-induced apoptosis of leukemia cells is mediated by a bimodal and differentially regulated residue-specific phosphorylation of heat-shock protein–27
442. Strategic formulation of APIGENIN-loaded PLGA nanoparticles for intracellular trafficking, DNA targeting and improved therapeutic effects in skin melanoma in vitro
443. Activation of p38 MAPK pathway contributes to the melanogenic property of APIGENIN in B16 cells
444. APIGENIN Attenuates 2-Deoxy-D-ribose-Induced Oxidative Cell Damage in HIT-T15 Pancreatic β-Cells
445. Dietary APIGENIN suppresses IgE and inflammatory cytokines production in C57BL/6N mice
446. Optimization of ultrasonic‐assisted enzymatic hydrolysis for the extraction of luteolin and APIGENIN from celery
447. Anticancer mechanism of APIGENIN and the implications of GLUT-1 expression in head and neck cancers
448. Determination of free radical scavenging activity of quercetin, rutin, luteolin and APIGENIN in H2O2-treated human ML cells K562.
449. Gastric relaxation induced by APIGENIN and quercetin: analysis of the mechanism of action
450. APIGENIN drives the production of reactive oxygen species and initiates a mitochondrial mediated cell death pathway in prostate epithelial cells
451. Determination and assay validation of luteolin and APIGENIN in human urine after oral administration of tablet of Chrysanthemum morifolium extract by HPLC
452. Cytotoxic effects of the dietary flavones chrysin and APIGENIN in a normal trout liver cell line
453. APIGENIN protects ovalbumin-induced asthma through the regulation of GATA-3 gene
454. Solubilities of APIGENIN in ethanol+ water at different temperatures
455. APIGENIN ameliorates gamma radiation-induced cytogenetic alterations in cultured human blood lymphocytes
456. Anti-mutagenic and pro-apoptotic effects of APIGENIN on human chronic lymphocytic leukemia cells
457. Determination of APIGENIN in rat plasma by high-performance liquid chromatography
458. Geminin is overexpressed in human pancreatic cancer and downregulated by the bioflavanoid APIGENIN in pancreatic cancer cell lines
459. APIGENIN and tangeretin enhance gap junctional intercellular communication in rat liver epithelial cells
460. APIGENIN induces apoptosis through mitochondrial dysfunction in U-2 OS human osteosarcoma cells and inhibits osteosarcoma xenograft tumor growth in vivo
461. Flavonoid APIGENIN modified gene expression associated with inflammation and cancer and induced apoptosis in human pancreatic cancer cells through inhibition of …
462. APIGENIN and cancer chemoprevention
463. APIGENIN Inhibits the Expression of IL-6, IL-8, and ICAM-1 in DEHP-Stimulated Human Umbilical Vein Endothelial Cells and In Vivo
464. Antigenotoxic effect of APIGENIN against mitomycin C induced genotoxic damage in mice bone marrow cells
465. Effects of genistein, APIGENIN, quercetin, rutin and astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice
466. Impact of adenomatous polyposis coli (APC) tumor supressor gene in human colon cancer cell lines on cell cycle arrest by APIGENIN
467. Labeling of APIGENIN with 131I and bioactivity of 131I-APIGENIN in male and female rats
468. The exposure of luteolin is much lower than APIGENIN when oral administration of Flos Chrysanthemi extract to rats
469. Functional activation of monoamine transporters by luteolin and APIGENIN isolated from the fruit of Perilla frutescens (L.) Britt
470. Antinociceptive effect of the Orbignya speciosa Mart.(Babassu) leaves: evidence for the involvement of APIGENIN
471. Synergistic anti-glioma effect of Hydroxygenkwanin and APIGENIN in vitro
472. Exploration of the wound healing potential of Helichrysum graveolens (Bieb.) Sweet: Isolation of APIGENIN as an active component
473. Chemopreventive potential of APIGENIN in 7, 12-dimethylbenz (a) anthracene induced experimental oral carcinogenesis
474. APIGENIN inhibits endothelial‐cell proliferation in G2/M phase whereas it stimulates smooth‐muscle cells by inhibiting P21 and P27 expression
475. APIGENIN protects gamma-radiation induced oxidative stress, hematological changes and animal survival in whole body irradiated Swiss albino mice
476. The dietary flavonoid APIGENIN enhances the activities of the anti-metastatic protein CD26 on human colon carcinoma cells
477. Variation of APIGENIN quantity in diploid and tetraploid Chamomilla recutita (L.) Rauschert
478. Flavonoids (APIGENIN, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells
479. Anti-inflammatory effect of APIGENIN-7-neohesperidoside (rhoifolin) in carrageenin-induced rat oedema model
480. APIGENIN suppresses the growth of colorectal cancer xenografts via phosphorylation and up-regulated FADD expression
481. Effects of APIGENIN on steroidogenesis and steroidogenic acute regulatory gene expression in mouse Leydig cells
482. Nitrogen-containing APIGENIN analogs: preparation and biological activity
483. Preparation of novel APIGENIN‐enriched, liposomal and non‐liposomal, antiinflammatory topical formulations as substitutes for corticosteroid therapy
484. Efficacy of PLGA-loaded APIGENIN nanoparticles in Benzo [a] pyrene and ultraviolet-B induced skin cancer of mice: Mitochondria mediated apoptotic signalling …
485. Citrus flavonoids luteolin, APIGENIN, and quercetin inhibit glycogen synthase kinase-3β enzymatic activity by lowering the interaction energy within the binding cavity
486. Inhibition of guinea pig intestinal peristalsis by the flavonoids quercetin, naringenin, APIGENIN and genistein
487. Anticlastogenic effect of APIGENIN in human lymphocytes treated with ethinylestradiol
488. Glycosidation of APIGENIN results in a loss of its activity on different growth parameters of arbuscular mycorrhizal fungi from the genus Glomus and Gigaspora
489. … of IGF-I production and proliferation of human leiomyomal smooth muscle cells by Scutellaria barbata D. Don in vitro: isolation of flavonoids of APIGENIN and luteolin as …
490. Total synthesis of APIGENIN 7, 4′-di-O-β-glucopyranoside, a component of blue flower pigment of Salvia patens, and seven chiral analogues
491. APIGENIN, a bioactive flavonoid from Lycopodium clavatum, stimulates nucleotide excision repair genes to protect skin keratinocytes from ultraviolet B-induced …
492. Oxidative coupling of APIGENIN
493. Suppression by APIGENIN of peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats
494. APIGENIN inhibits NNK-induced focal adhesion kinase activation in pancreatic cancer cells
495. APIGENIN chemotypes of Matricaria chamomilla L.
496. APIGENIN di-C-glycosylflavones of Angiopteris (Marattiales)
497. Quantitative determination of APIGENIN and its metabolism in rat plasma after intravenous bolus administration by HPLC coupled with tandem mass spectrometry
498. APIGENIN–strong cytostatic and anti-angiogenic action in vitro contrasted by lack of efficacy in vivo
499. Modulation of radiation-induced and mitomycin C-induced chromosome damage by APIGENIN in human lymphocytes in vitro
500. Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic APIGENIN homodimers linked with defined-length poly (ethylene …
501. Characterization of APIGENIN and Luteolin Derivatives from Oil Palm (Elaeis guineensis Jacq.) Leaf Using LC–ESI-MS/MS
502. Effect of APIGENIN on the reproductive system in male mice
503. Preparing APIGENIN from leaves of Adinandra nitida
504. Bioassay‐guided isolation of APIGENIN with GABA‐benzodiazepine activity from Tanacetum parthenium
505. Complexation of APIGENIN and luteolin in weld lake: a DFT/TDDFT investigation
506. Flavonoid quercetin, but not APIGENIN or luteolin, induced apoptosis in human myeloid leukemia cells and their resistant variants.
507. APIGENIN blocks induction of vascular endothelial growth factor mRNA and protein in progestin-treated human breast cancer cells
508. The flavonoid APIGENIN potentiates the growth inhibitory effects of gemcitabine and abrogates gemcitabine resistance in human pancreatic cancer cells
509. On the accumulation of APIGENIN in chamomile flowers
510. Dietary APIGENIN attenuates the development of atopic dermatitis-like skin lesions in NC/Nga mice
511. APIGENIN inhibits the TNFα-induced expression of eNOS and MMP-9 via modulating Akt signalling through oestrogen receptor engagement
512. Effect of dietary APIGENIN on colonic ornithine decarboxylase activity, aberrant crypt foci formation, and tumorigenesis in different experimental models
513. Alfalfa (Medicago sativa L.) APIGENIN glycosides and their effect on the pea aphid (Acyrthosiphon pisum)
514. Chlorpromazine and APIGENIN reduce adenovirus replication and decrease replication associated toxicity
515. APIGENIN inhibits laser-induced choroidal neovascularization and regulates endothelial cell function
516. New progress in the pharmacology of APIGENIN [J]
517. APIGENIN induces DNA damage through the PKCδ-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA …
518. APIGENIN inhibits TGF-β1 induced fibroblast-to-myofibroblast transition in human lung fibroblast populations
519. Protoapigenone, a natural derivative of APIGENIN, induces mitogen-activated protein kinase-dependent apoptosis in human breast cancer cells associated with …
520. APIGENIN decreases expression of the myofibroblast phenotype
521. Effects of APIGENIN on the expression of angiotensin-converting enzyme 2 in kidney in spontaneously hypertensive rats
522. Effect of emodin and APIGENIN on invasion of human ovarian carcinoma HO-8910PM cells in vitro
523. APIGENIN decreases hemin-mediated heme oxygenase-1 induction
524. APIGENIN induces c-Myc-mediated apoptosis in FRO anaplastic thyroid carcinoma cells
525. APIGENIN reduces human insulin fibrillation in vitro and protects SK-N-MC cells against insulin amyloids
526. APIGENIN, a dietary flavonoid, sensitizes human T cells for activation-induced cell death by inhibiting PKB/Akt and NF-κB activation pathway
527. Synthesis of a complete series of O-methyl analogues of naringenin and APIGENIN
528. The pharmacokinetics of raloxifene and its interaction with APIGENIN in rat
529. Effect of luteolin and APIGENIN on rosmarinic acid bioavailability in Caco-2 cell monolayers
530. APIGENIN: is it a pro-or anti-inflammatory agent?
531. Determination of luteolin and APIGENIN in celery using ultrasonic‐assisted extraction based on aqueous solution of ionic liquid coupled with HPLC quantification
532. Production of cell-associated polysaccharides of Rhizobium fredii USDA205 is modulated by APIGENIN and host root extract
533. Reversed-phase high-performance liquid chromatography analysis of APIGENIN and its glucosides in flowers of Matricaria chamomilla and chamomile extracts
534. Time course changes of anti-and pro-apoptotic proteins in APIGENIN-induced genotoxicity
535. Inhibition of superoxide anion-mediated impairment of endothelium by treatment with luteolin and APIGENIN in rat mesenteric artery
536. Effects of lycopene and APIGENIN on human umbilical vein endothelial cells in vitro under angiogenic stimulation
537. Inhibitory effect of APIGENIN on benzo (a) pyrene‐mediated genotoxicity in Swiss albino mice
538. The chemopreventive flavonoid APIGENIN confers radiosensitizing effect in human tumor cells grown as monolayers and spheroids
539. The spectroscopic properties of anticancer drug APIGENIN investigated by using DFT calculations, FT-IR, FT-Raman and NMR analysis
540. RP-HPLC-DAD detrmination of flavonoids: separation of quercetin, luteolin and APIGENIN in Marchantia convoluta
541. APIGENIN attenuates neointima formation via suppression of vascular smooth muscle cell phenotypic transformation
542. APIGENIN prevents development of medroxyprogesterone acetate-accelerated 7, 12-dimethylbenz (a) anthracene-induced mammary tumors in Sprague–Dawley rats
543. … ‐independent pathway for inhibitory phosphorylation of cyclin‐dependent kinase p34cdc2 and concomitant G2/M arrest by the chemopreventive flavonoid APIGENIN
544. Enhancement of p53 expression in keratinocytes by the bioflavonoid APIGENIN is associated with RNA‐binding protein HuR
545. Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by APIGENIN, a plant flavonoid.
546. Dietary flavonoid APIGENIN inhibits high glucose and tumor necrosis factor α-induced adhesion molecule expression in human endothelial cells
547. Column-switching high-performance liquid chromatographic assay for determination of APIGENIN and acacetin in human urine with ultraviolet absorbance detection
548. APIGENIN prevents deregulation in the expression pattern of cell-proliferative, apoptotic, inflammatory and angiogenic markers during 7, 12-dimethylbenz [a] …
549. A short and facile synthetic route to hydroxylated flavones. New syntheses of APIGENIN, tricin, and luteolin
550. APIGENIN isolated from the seeds of Perilla frutescens britton var crispa (Benth.) inhibits food intake in C57BL/6J mice
551. The effect of APIGENIN on pharmacokinetics of imatinib and its metabolite N-desmethyl imatinib in rats
552. APIGENIN induces apoptosis via downregulation of S‐phase kinase‐associated protein 2‐mediated induction of p27Kip1 in primary effusion lymphoma cells
553. Hexaconazole induces antioxidant protection and APIGENIN-7-glucoside accumulation in Matricaria chamomilla plants subjected to drought stress
554. Involvement of monoamine oxidase and noradrenaline uptake in the positive chronotropic effects of APIGENIN in rat atria
555. The flavonoid APIGENIN downregulates CDK1 by directly targeting ribosomal protein S9
556. APIGENIN-7-O-β-D-glucopyranoside, an anti-HIV principle from Kummerowia striata
557. Relationships between the larval growth inhibition of Caenorhabditis elegans by APIGENIN derivatives and their structures
558. APIGENIN inhibits larval growth of Caenorhabditis elegans through DAF-16 activation
559. Electrochemical behavior of APIGENIN at a glassy carbon electrode and its analytical application
560. Differential effects of quercetin, APIGENIN and genistein on signalling pathways of protease‐activated receptors PAR1 and PAR4 in platelets
561. Influence of vehicle, distant topical delivery, and biotransformation on the chemopreventive activity of APIGENIN, a plant flavonoid, in mouse skin
562. Antioxidant properties, superoxide dismutase and glutathione reductase activities in HepG2 cells with a fungal endophyte producing APIGENIN from pigeon pea …
563. APIGENIN inhibits cell migration through MAPK pathways in human bladder smooth muscle cells
564. The dietary flavones APIGENIN and luteolin impair smooth muscle cell migration and VEGF expression through inhibition of PDGFR-β phosphorylation
565. Synthesis of carpachromene and related isopentenylated derivatives of APIGENIN
566. 5-Fluorouracil combined with APIGENIN enhances anticancer activity through induction of apoptosis in human breast cancer MDA-MB-453 cells
567. Isolation and structure elucidation of ligustroflavone, a new APIGENIN triglycoside from the leaves of Ligustrum vulgare L.
568. An acylated flavone APIGENIN 7-O-β-D-(4 ″-cis-p-coumaroyl) glucoside from Echinops echinatus
569. Direct semi-synthesis of the anticancer lead-drug protoapigenone from APIGENIN, and synthesis of further new cytotoxic protoflavone derivatives
570. Micelles of TPGS modified APIGENIN phospholipid complex for oral administration: preparation, in vitro and in vivo evaluation
571. Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by APIGENIN in human prostate carcinoma cells
572. Inhibition of TPA‐induced cyclooxygenase‐2 (COX‐2) expression by APIGENIN through downregulation of Akt signal transduction in human keratinocytes
573. Akt inhibition enhances the cytotoxic effect of APIGENIN in combination with PLX4032 in anaplastic thyroid carcinoma cells harboring BRAF V600E
574. Estimation of APIGENIN, an anxiolytic constituent, in Turnera aphrodisiaca
575. APIGENIN di-and trirhamnoside from Asplenium normale in Malaysia
576. The effect of APIGENIN on cyclophosphamide and doxorubicin genotoxicity in vitro and in vivo
577. Pancreatic Β-cell protective effect of rutin and APIGENIN isolated from Teucrium polium
578. APIGENIN, chrysin, and luteolin selectively inhibit chymotrypsin-like and trypsin-like proteasome catalytic activities in tumor cells
579. APIGENIN inhibits tumor necrosis factor alpha plus high glucose-induced LOX-1 expression in human endothelial cells
580. Effects of APIGENIN, lycopene and astaxanthin on 7β-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells
581. Interspecies difference of luteolin and APIGENIN after oral administration of Chrysanthemum morifolium extract and prediction of human pharmacokinetics
582. Proteomic study of granulocytic differentiation induced by APIGENIN 7-glucoside in human promyelocytic leukemia HL-60 cells
583. Sub-toxic dose of APIGENIN sensitizes HepG2 cells to TRAIL through ERK-dependent up-regulation of TRAIL receptor DR5
584. APIGENIN 7-glucoside diacetates in ligulate flowers of Matricaria chamomilla
585. APIGENIN and LY294002 prolong EGF-stimulated ERK1/2 activation in PC12 cells but are unable to induce full differentiation
586. APIGENIN-induced apoptosis in cervical cancer cell lines
587. Spectrophotometric study of anthocyan copigmentation reactions. 4. Malvin and APIGENIN 7-glucoside
588. Effect of APIGENIN on proliferation and apoptosis of human lung cancer NCI-H460 cells
589. The flavonoid APIGENIN inhibits the proliferation of prostatic stromal cells via the MAPK-pathway and cell-cycle arrest in G1/S
590. Expression of transforming growth factor-and determination of apoptotic index in histopathological sections for assessment of the effects of APIGENIN (4′, 5′, 7′ …
591. APIGENIN isolated from the medicinal plant Elsholtzia rugulosa prevents β-amyloid 25–35-induces toxicity in rat cerebral microvascular endothelial cells
592. 5, 6-Dichloro-ribifuranosylbenzimidazole-and APIGENIN-induced sensitization of colon cancer cells to TNF-α-mediated apoptosis
593. Effect of the phenolic compounds APIGENIN and carnosic acid on oral carcinogenesis in hamster induced by DMBA
594. Semisynthesis of APIGENIN and acacetin-7-O-β-D-glycosides from naringin and their cytotoxic activities
595. Up‐regulation of insulin‐like growth factor binding protein‐3 by APIGENIN leads to growth inhibition and apoptosis of 22Rv1 xenograft in athymic nude mice
596. Activation of Cl− channel and Na+/K+/2Cl− cotransporter in renal epithelial A6 cells by flavonoids: genistein, daidzein, and APIGENIN
597. Neuroprotective effects of APIGENIN on acute transient focal cerebral ischemia-reperfusion injury in rats
598. Studies of the interaction between APIGENIN and bovine serum albumin by spectroscopic methods
599. Anti-proliferation and chemo-sensitization effects of APIGENIN on human lung cancer cells
600. APIGENIN glycosides from the flowers of Bellis perennis L.
601. The natural flavonoid APIGENIN suppresses Th1-and Th2-related chemokine production by human monocyte THP-1 cells through mitogen-activated protein kinase …
602. KLF4 overexpression and APIGENIN treatment down regulated anti-apoptotic Bcl-2 proteins and matrix metalloproteinases to control growth of human …
603. Differential mechanisms for the inhibition of human cytochrome P450 1A2 by APIGENIN and genistein
604. APIGENIN glycosides from Thunbergia fragrans and Ruellia t uberosa
605. (Delphinidin 3-gentiobiosyl)(APIGENIN 7-glucosyl) malonate from the flowers of Eichhornia crassipes
606. Alfalfa (Medicago sativa L.) Flavonoids. 1. APIGENIN and Luteolin Glycosides from Aerial Parts
607. Study on pro-apoptotic effect of APIGENIN on human gastric cancer cells and its underlying mechanisms [J]
608. Quinacrine and a novel APIGENIN dimer can synergistically increase the pentamidine susceptibility of the protozoan parasite Leishmania
609. The dietary flavonoid APIGENIN blocks phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in breast cell lines
610. APIGENIN‐induced nitric oxide production involves calcium‐activated potassium channels and is responsible for antiangiogenic effects
611. Use of hollow fiber liquid phase microextraction and HPLC for extraction and determination of APIGENIN in human urine after consumption of Satureja sahendica …
612. Evaluation of hepatic clearance and drug-drug interactions of luteolin and APIGENIN by using primary cultured rat hepatocytes
613. A novel APIGENIN modified glassy carbon sensor electrode for the determination of copper ions in soil samples
614. HPTLC densitometric quantification of glycyrrhizin, glycyrrhetinic acid, APIGENIN, kaempferol and quercetin from Glycyrrhiza glabra
615. Interactions of the monomeric and dimeric flavones APIGENIN and amentoflavone with the plasma membrane of L929 cells; a fluorescence study
616. APIGENIN enhances the cytotoxic effects of tumor necrosis factor-related apoptosis-inducing ligand in human rheumatoid arthritis fibroblast-like synoviocytes
617. APIGENIN inhibits tumor necrosis factor α–induced cell proliferation and prostaglandin E2 synthesis by inactivating NFκB in endometriotic stromal cells
618. Three Adducts of Butenolide and APIGENIN Glycoside from the Leaves of Machilus japonica
619. Silica‐based monolithic column with evaporative light scattering detector for HPLC analysis of bacosides and APIGENIN in Bacopa monnieri
620. Sequential hTERT knockdown and APIGENIN treatment inhibited invasion and proliferation and induced apoptosis in human malignant neuroblastoma SK-N-DZ and …
621. An investigation on the interaction of DNA with hesperetin/APIGENIN in the presence of CTAB by resonance Rayleigh light scattering technique and its analytical …
622. Determination of quercetin, luteolin, APIGENIN and acacetin in Flos Chrysanthemi Indici by RP-HPLC
623. Inhibition of HIF‐1 alpha and VEGF expression by the chemopreventive bioflavonoid APIGENIN is accompanied by Akt inhibition in human prostate carcinoma PC3‐M …
624. Validation of a capillary electrophoresis method for the quantitative determination of free and total APIGENIN in extracts of Chamomilla recutita
625. Unbalanced activation of ERK1/2 and MEK1/2 in APIGENIN-induced HeLa cell death
626. APIGENIN di-C-glycosides (ACG) content and composition in grains of bread wheat (Triticum aestivum) and related species
627. APIGENIN inhibits release and gene expression of monocyte chemoattractant protein 1 (MCP-1) in J774. 2 macrophages
628. APIGENIN sensitizes Huh-7 human hepatocellular carcinoma cells to TRAIL-induced apoptosis
629. APIGENIN increases osteoblastic differentiation and inhibits tumor necrosis factor-α-induced production of interleukin-6 and nitric oxide in osteoblastic MC3T3-E1 cells
630. Subtoxic levels of APIGENIN inhibit expression and secretion of VEGF by uveal melanoma cells via suppression of ERK1/2 and PI3K/Akt pathways
631. Effects of dietary APIGENIN on tumor latency, incidence and multiplicity in a medroxyprogesterone acetate-accelerated 7, 12-dimethylbenz (a) anthracene-induced …
632. Modulation of UVB‐induced and basal cyclooxygenase‐2 (COX‐2) expression by APIGENIN in mouse keratinocytes: Role of USF transcription factors
633. Theoretical investigation of the structural and electronic properties of luteolin, APIGENIN and their deprotonated species
634. Enhancement of pentobarbital-induced sleep by APIGENIN through chloride ion channel activation
635. APIGENIN and amentoflavone glycosides in the Psilotaceae and their phylogenetic significance
636. Biotransformations of quercetin and APIGENIN by a cell suspension culture of Cannabis sativa
637. Combination of N-(4-hydroxyphenyl) retinamide and APIGENIN suppressed starvation-induced autophagy and promoted apoptosis in malignant neuroblastoma cells
638. APIGENIN attenuates dopamine-induced apoptosis in melanocytes via oxidative stress-related p38, c-Jun NH2-terminal kinase and Akt signaling
639. The flavonoid APIGENIN suppresses vitamin D receptor expression and vitamin D responsiveness in normal human keratinocytes
640. Development and Validation of a RP-HPLC Method for The Simultaneous Determination of Luteolin and APIGENIN in Herb of Achillea millefolium L.
641. Determination of antimutagenic properties of APIGENIN-7-O-rutinoside, a flavonoid isolated from Mentha longifolia (L.) Huds. ssp. longifolia with yeast DEL assay
642. XLI.—Apiin and APIGENIN. Part II. Note on vitexin
643. Protective effect of APIGENIN against hydrogen peroxide induced genotoxic damage on cultured human peripheral blood lymphocytes.
644. The extraction of APIGENIN and luteolin from the sage Salvia officinalis L. from Jordan
645. Biotransformation of chrysin and APIGENIN by Cunninghamella elegans
646. Phorbol ester or epidermal growth‐factor‐induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by APIGENIN and wogonin
647. A Mew Acylated APIGENIN 4’–O–β–D–glucoside from the Leaves of Lycopodium clavatum L
648. APIGENIN accelerates lipopolysaccharide induced apoptosis in mesenchymal stem cells through suppressing vitamin D receptor expression
649. APIGENIN suppresses migration and invasion of transformed cells through down-regulation of CXC chemokine receptor 4 expression
650. UV spectrometric and DC polarographic studies on APIGENIN and luteolin
651. APIGENIN 4′-O-β-d-glucoside 7-O-β-d)-glucuronide: The copigment in the blue pigment of Centaurea cyanus
652. A simple HPLC method for the determination of APIGENIN in mouse tissues
653. An APIGENIN-induced decrease in K-antigen production by Sinorhizobium sp. NGR234 is y4gM-and nodD1-dependent
654. Identification and quantitative determination of Luteolin and APIGENIN in the aerial parts and an extract of Stachys lavandulifolia by HPLC
655. Über die Verbreitung von Flavonoiden bei pleurokarpen Laubmoosen II. APIGENIN and APIGENIN-7-rhamnoglucosid bei Pleurozium schreberi (Willd.) Mitt.
656. miR-138 overexpression is more powerful than hTERT knockdown to potentiate APIGENIN for apoptosis in neuroblastoma in vitro and in vivo
657. Effect and mechanism of APIGENIN on VEGF expression in human breast cancer cells
658. Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent APIGENIN homodimers and their derivatives
659. Analysis of APIGENIN in Blumea balsamifera Linn DC. and its inhibitory activity against aldose reductase in rat lens
660. APIGENIN inhibits growth and motility but increases gap junctional coupling intensity in rat prostate carcinoma (MAT-LyLu) cell populations
661. Determination of APIGENIN by LC with electrochemical detection
662. Biochemistry, Molecular Biology: APIGENIN, Tyrosinase Inhibitor Isolated from the Flowers of Hemisteptia lyrata Bunge
663. Inhibitory effects of naringenin, kaempherol, and APIGENIN on cholesterol biosynthesis in HepG2 and MCF-7 cells
664. Bcl-2 inhibitor and APIGENIN worked synergistically in human malignant neuroblastoma cell lines and increased apoptosis with activation of extrinsic and intrinsic …
665. WITHDRAWN: APIGENIN: A potent antigenotoxic and anticlastogenic agent
666. APIGENIN 7β-rutinoside, a new flavonoid from the leaves of Citrus paradisi
667. APIGENIN derivatives from Paulownia tomentosa Steud. var. tomentosa stem barks
668. The new flavone ester APIGENIN 7-Op-hydroxybenzoate and three di-C-glycosylflavones from Pteris vittata
669. … evoked adhesion molecule genetic alterations in astrocytes isolated from stroke-prone spontaneously hypertensive rats and the APIGENIN inhibition of their …
670. The efficient total synthesis of bis-glycosyl APIGENIN from naringenin: a greener way
671. High-performance liquid chromatographic determination and pharmacokinetic study of APIGENIN-7-O-β-D-glucoside in rat plasma after intravenous administration
672. Protective effects of APIGENIN and quercetin on aflatoxin B 1-induced immunotoxicity in mice
673. Investigation of APIGENIN-7-O-β-glucoside hydrolysis by β-glucosidase from almonds
674. Enzyme pretreatment and negative pressure cavitation extraction of genistein and APIGENIN from the roots of pigeon pea [Cajanus cajan (L.) Millsp.] and the evaluation …
675. APIGENIN reduces cyclosporine-A induced changes in lipid hydroperox-ides and total antioxidants in Sprague-Dawley rats.
676. N-Myc knockdown and APIGENIN treatment controlled growth of malignant neuroblastoma cells having N-Myc amplification
677. Response of soybean fungal and oomycete pathogens to APIGENIN and genistein
678. Total synthesis of three naturally occurring 6, 8-di-C-glycosylflavonoids: phloretin, naringenin, and APIGENIN bis-C-β-D-glucosides
679. XXVI.—A synthesis of pyrylium salts of anthocyanidin type. Part IV. Flavylium salts related to chrysin, APIGENIN, and luteolin
680. Effects of APIGENIN on cell proliferation of human pancreatic carcinoma cell line BxPC-3 in vitro
681. APIGENIN glycosides from Euphorbia humifusa Wild
682. The para-O-methylation of APIGENIN to acacetin by cell-free extracts of Robinia pseudoacacia L.
683. Effect of APIGENIN on the cardiomyocyte apoptosis in rats with ischemia and reperfusion and the expression of Bcl-2, Bax, Caspase-3
684. APIGENIN-7-methylglucuronide from Cynara cardunculus L.
685. Observation of APIGENIN anionic clusters in the gas phase
686. Inhibition of PKB/Akt activity involved in APIGENIN-induced apoptosis in human gastric carcinoma cells
687. The promising anticancer efficacy of parsley seeds flavonoid (APIGENIN) in induced mammary adenocarcinoma (AMN3) mice
688. Aluminium (III), Fe (II) Complexes and Dyeing Properties of APIGENIN (5, 7, 4′-trihydroxy flavone)
689. Studies on the anticancer effect of APIGENIN in KB cell xenograft nude mouse model
690. Two New APIGENIN Glycosides from Cephalotaxus Harringtonia Var. Harringtonia
691. HPTLC determination of APIGENIN in some Iranian liquid products of Matricaria chamomilla L.
692. Dietary APIGENIN regulates high glucose and hypoxic reoxygenation-induced reductions in apelin expression in human endothelial cells
693. Effects of APIGENIN on Glutamate-induced [Ca2+] i Increases in Cultured Rat Hippocampal Neurons
694. Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by APIGENIN via the inhibition of p38 mitogen-activated protein kinase-dependent matrix …
695. Calcium-and phosphatidylinositol 3-kinase/Akt-dependent activation of endothelial nitric oxide synthase by APIGENIN
696. Effect of salicylic acid on flavonoids, APIGENIN, anthocyanin and carbohydrate in Matricaria chamomilla L.
697. Caecal absorption of vitexin-2-O-xyloside and its aglycone APIGENIN, in the rat
698. On the adsorption and electrochemical oxidation of flavones APIGENIN and acacetin at a glassy carbon electrode
699. Hierarchy of carcinoma cell responses to APIGENIN: gap junctional coupling versus proliferation
700. Syntheses and crystal structures of two APIGENIN alkylation derivatives
701. Interaction of bovine serum albumin with luteolin and APIGENIN
702. HPLC determination of luteolin and APIGENIN in herba ecliptae
703. Influence of biotransformation of luteolin, luteolin 7-O-glucoside, 3′, 4′-dihydroxyflavone and APIGENIN by cultured rat hepatocytes on antioxidative capacity and …
704. Isolation, purification and identification of APIGENIN-7-O-# beta#-D-glucuronide in marchantia convoluta with silica column chromatography, RP-HPLC and LC-ESI-MS
705. In vitro effects of myricetin, morin, APIGENIN,(+)-taxifolin,(+)-catechin,(−)-epicatechin, naringenin and naringin on cytochrome b5 reduction by purified NADH …
706. Rutinosides and vicianosides of quercetin, APIGENIN and luteolin from Sympohoricarpus albus L. Blake (Caprifoliaeae)
707. The influence of APIGENIN on membrane and action potential in the liverwort Conocephalum conicum
708. The promotive effects of antioxidative APIGENIN on the bioavailability of paclitaxel for oral delivery in rats
709. Studies on the effects of anti-inflammatory and analgesic of APIGENIN [J]
710. … , and Other Constituents from the leaves of Ochroma pyramidale (Balsa Wood, Bombacaceae): Preferred Conformations of 8-C-β-D-Glucopyranosyl-APIGENIN …
711. LC-MS/MS simultaneous determination of scutellarin and APIGENIN of Herba Scutellariae barbatae produced in different districts
712. Size and branching effects on the fluorescence of benzylic dendrimers possessing one APIGENIN fluorophore at the core
713. APIGENIN modulates insulin-like growth factor axis: implications for prevention and therapy of prostate cancer
714. Chemosensitization effects of APIGENIN on cisplatin in human nasopharyngeal carcinoma CNE-2Z cells
715. Determination of hesperetin, luteolin and APIGENIN in flos buddlejae by capillary electrophoresis
716. Chromatographic and spectrophotometric evidence for the occurrence of luteolin and APIGENIN C-glycosides in the cotyledons of buckwheat seedlings
717. Effect of APIGENIN on proliferation, cell cycle and apoptosis of mouse T cells in vitro
718. 555. The flavonoid glycosides of Dahlia variabilis. Part I. General introduction. Cyanidin, APIGENIN, and luteolin glycosides from the variety “Dandy.”
719. Inhibition of interleukin-4 production in activated T cells via down-regulation of NF-AT DNA binding activity by APIGENIN, a flavonoid present in dietary plants
720. CLVI.—A synthesis of pyrylium salts of anthocyanidin type. Part VI. Polyhydroxyflavylium salts related to chrysin, APIGENIN, lotoflavin, luteolin, galangin, fisetin, and …
721. APIGENIN regulates lipopolysaccharides-induced activation of inflammasome
722. Simultaneously determined of quercetin, luteolin and APIGENIN in Rosa laevigata by HPLC
723. Dietary flavonoid APIGENIN inhibits endothelin-1-induced contraction of collagen gel
724. Studies on fluorescence quenching method for determination of APIGENIN with CdSe/CdS quantum dots
725. Flavanones and related compounds. III. The reduction of luteolin and APIGENIN trimethyl ether with sodium amalgam
726. Isolation of gram quantities of a rhamnoglucoside of APIGENIN from grapefruit
727. 97: APIGENIN inhibits pancreatic cancer cell proliferation via down-regulation of hypoxia inducible factor-1Α (HIF-1Α) and the glucose transporter (GLUT-1)
728. High performance liquid chromatographic method for the determination of APIGENIN and selected flavonoids in human plasma using electrochemical detection
729. Protective effect of APIGENIN on neurons against oxygen‐glucose deprivation/reperfusion induced injury
730. The effect of APIGENIN on proliferation and NO secretion and phagocytosis of RAW264. 7 cells
731. APIGENIN affects semen parameters in male mice
732. The determination of APIGENIN 7-0-beta-glucoside in the Matricaria chamomilla ligulate flowers
733. The protective effects of APIGENIN in myocardium of rats with ischemia reperfusion injury J
734. Optimal recovery of APIGENIN from Torreya grandis by extraction, fractionation and structure elucidation
735. Arbuscular mycorrhizal formation of crucifer leaf mustard induced by flavonoids APIGENIN and daidzein
736. Study on estrogenic effect of genistein and APIGENIN in vitro
737. Involvement of K+-Cl–Cotransport in the APIGENIN-Induced Generation of Reactive Oxygen Species in IMR-32 Human Neuroblastoma Cells
738. VEGF expression is inhibited by APIGENIN in human breast cancer cells
739. The Research on the Mechanism of the Effect of APIGENIN on the Leydig Cells of Rats [J]
740. Über die Verbreitung von Flavonoiden bei pleurokarpen Laubmoosen I. APIGENIN-7-rhamnoglucosid bei Hylocomium splendens (Hedw.) Br. eur.
741. The first total synthesis of 7-O-β-d-glucopyranosyl-4′-O-α-l-rhamnopyranosyl APIGENIN via a hexanoyl ester-based protection strategy
742. The variability of (Z)‐ and (E)‐2‐β‐D‐glucopyranosyloxy‐4‐methoxycinnamic acids and APIGENIN glucosides in diploid and tetraploid Chamomilla recutita
743. Total synthesis of APIGENIN-4′-yl 2-O-(p-coumaroyl)-β-d-glucopyranoside
744. Transfer of apiose from UDP-apiose to 7-O-(β-D-glucosyl)-APIGENIN and 7-O-(β-D-glucosyl)-chrysoeriol with an enzyme preparation from parsley
745. APIGENIN-induced apoptosis of bladder cancer cell BIU-87 and its mechanism [J]
746. Inhibitory effects of APIGENIN and kaempferol on the essential solute carrier transporters
747. HPTLC method for quantification of APIGENIN in the dried root powder of Gmelina arborea Linn.
748. Isolation and Purification of APIGENIN and Luteolin from Pteris multifida Poir. by High-speed Counter-current Chromatography.
749. Biological synthesis of 7-O-methyl APIGENIN from naringenin using Escherichia coli expressing two genes
750. Effect of APIGENIN on expression of VEGF in cerebral ischemia and reperfusion rats
751. Pharmacokinetics and tissue distribution of APIGENIN niosomes
752. Determination of Psoralen and APIGENIN in Radix Fici Hirtae by HPLC
753. Endothelium-dependent vasorelaxation effects induced by APIGENIN on the thoracic aorta of rats and its possible mechanism
754. Effects of APIGENIN on caveolin-1 expression of focal cerebral ischemia-reperfusion in rats.
755. Improvement of the antioxidant activity of APIGENIN in linoleic acid system by o-prenylation
756. An enzyme‐linked immunosorbent assay for the measurement of plasma flavonoids in mice fed APIGENIN‐C‐glycoside
757. Effect of high dose APIGENIN on antioxidase activity and DNA damage in rats
758. 17. Chalkones: a new synthesis of chrysin, APIGENIN, and luteolin
759. Preparation of APIGENIN niosomes and properties investigation
760. APIGENIN and kaempferol effects on oral cancer FADU cells
761. Quantitative Determination of APIGENIN in Pteris semipinnata L. by HPLC [J]
762. A New Flavone Glucoside, APIGENIN 7-O-glucoside 4′-acetate and a New Fern Constituent, Quercetin 3-O-rhamnoside-7-O-glucoside from Dryopteris villarii
763. Effects of APIGENIN, an antioxidant, on the bioavailability and pharmacokinetics of etoposide
764. Pre-formulation study on APIGENIN in solid lipid nanoparticles
765. Three new flavonoid glycosides, kaempferol 3-O-(caffeoylrhamnoside), APIGENIN 4′-O-(caffeoylglucoside) and 4′-O-(feruloylglucoside) from Dryopteris villarii
766. High-performance thin-layer chromatographic quantification of kaempferol and APIGENIN in the whole-plant powder of Sida spinosa Linn.
767. Acute toxicity, genetic toxicity and sub-chronic toxicity of APIGENIN
768. The research on the effect of APIGENIN injected to lateral brain ventricle on the reproductive axis of female rat
769. Recognition property and mechanism of molecularly imprinted polymers of APIGENIN
770. Sub-cellular distribution and antioxidant potential of plant flavonoid APIGENIN
771. Neuroprotective Effects of APIGENIN on Acute Transient Focal Cerebral Ischemia-reperfusion Injury in Rats [J]
772. APIGENIN augments the growth inhibitory effects of doxorubicin in breast cancer cells derived from African American patients
773. The Anti-Inflammatory Mechanisms of the Flavonoid APIGENIN In Vitro and In Vivo
774. Enhancement of TRAIL-induced apoptosis in human hepatocellular carcinoma cells by APIGENIN
775. CXVI.—Notes on luteolin and APIGENIN
776. Inhibitory effects of APIGENIN on the expression of GATA-3 and Th2 cytokines in asthmatic mice
777. Induction effects of APIGENIN, luteolin and vinpocetin on neutral endopeptidase (NEP) and angiotensin-converting enzyme activity (ACE) of SK-N-SH cells
778. HPLC investigation on the determination of APIGENIN and its interaction with human serum albumin
779. Development of RP-HPLC assay for determination of total luteolin and APIGENIN in plasma and its application to pharmacokinetics after single oral dose of …
780. 6, 8,-di-C-β-D-Arabinopyranosyl APIGENIN from Thea sinensis var. macrophylla
781. Protective Effect of APIGENIN against Ethinylestradiol induced Toxic Effects in the Third Instar Larvae of Transgenic Drosophila melanogaster (hsp70-lacZ) Bg 9
782. On the isolation of APIGENIN from manchurian kaoliang (andropogon sorghum, brot)
783. Determination of Quercetin, APIGENIN and Luteolin in Viola yedoensis Makino by RP-HPLC
784. The study on separation and purification of APIGENIN using collagen fiber adsorbent
785. Progress in the research of pharmacology of APIGENIN [J]
786. APIGENIN induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in athymic nude mice
787. APIGENIN causes growth arrest in pancreatic cancer cells through down-regulation of the replication inhibitor protein, Geminin via both transcription and ubiquitin …
788. APIGENIN induction of p53-independent apoptosis in MDA-MB-231 breast cancers
789. Anti cancer activity of APIGENIN isolated from Sorghum (Sorghum bicolor L. Moench)
790. The first total synthesis of APIGENIN 7-O-β-D-cellobiosyl-4′-O-β-D-glucopyranoside isolated from Salvia uliginosa
791. The Roles of APIGENIN on Leydig Cells in Testes of Rats [J]
792. Growth and telomerase inhibition of SK-MEL 28 melanoma cell line by a plant flavonoid, APIGENIN
793. Effect of APIGENIN on gap junctional intercellular communication in human Tenon’s capsule fibroblasts.
794. HPLC determination of parthenolide and APIGENIN contents versus label claims in Iranian products
795. Role of –cotransporter in the APIGENIN-induced Stimulation of Melanogenesis in B16 Melanoma Cells
796. Researches on the Structure and Antioxidant Activity of APIGENIN-La (III) Complex
797. Theoretical Study of the Structural and Electronic Properties of Luteolin and APIGENIN Dyes
798. APIGENIN induces pancreatic cancer cell apoptosis by a P53-mediated mechanism
799. The Process Research of Extraction of APIGENIN in Apium graveolens [J]
800. APIGENIN inhibits pancreatic cancer cell proliferation via down-regulation of the GLUT-1 glucose transporter through the phosphoinositide 3-kinase (PI3K)/Akt …
801. Thermospray liquid chromatography-mass spectrometry (TSP LC-MS) analysis of acetylated APIGENIN 7-glucosides from Chamomilla recutita
802. Synthesis of water-soluble APIGENIN
803. APIGENIN suppresses IKK activation and downstream signaling leading to prostate cancer inhibition.
804. Determination of Quercetin, Kaempferol, Luteolin, APIGENIN in Semen Plantaginis By RP-HPLC [J]
805. Study on Interaction between APIGENIN and Human Serum Albumin by Spectroscopy and Molecular Modeling [J]
806. Protective Effect and Mechanisms of APIGENIN against Free Radical-induced DNA Damage [J]
807. LC determination of luteolin-7-O-β-D-glucoside and APIGENIN-7-O-β-D-glucoside in rat plasma after administration of Humulus scandens extract and its application …
808. APIGENIN blocks tumor growth, invasion and metastasis by upregulation of maspin in TRAMP model
809. AMPK-mTOR axis as key target for chemoprevention of UV-induced skin cancer by the bioflavonoid APIGENIN
810. APIGENIN A Potent Anti-Inflammatory Flavonoid: Its Efficacy In Lung Inflammation And Target Identification Provides Novel Potential Alternative Therapeutic …
811. Plant flavonoid APIGENIN preferentially binds with GC-rich DNA sequences and inhibits DNA methylation
812. Transcriptional repression of androgen receptor in human prostate cancer cells by plant flavone APIGENIN
813. Research on joint anti-MRSA activity of APIGENIN in vitro
814. The Effect of APIGENIN on the Estrous Cycle in Female SD Mice [J]
815. Effects of Genistein, APIGENIN, Quercetin, Rutin and Astilbin on xanthine oxidase activities and serum uric acid levels in hyperuricemic mice
816. Content determination of luteolin and APIGENIN in Mongolian medicine Scabiosa tschilliensis by HPLC
817. Simultaneous determination of APIGENIN and kaempferol in the Wikstroemia indica (L.) CA Mey. by HPLC [J]
818. Preparation of APIGENIN solid lipid nanoparticles
819. Effect of APIGENIN from mallotus apelta on proliferation and apoptosis in nude mice bearing human gastric carcinoma
820. Antiinflammatory and Antinociceptive properties of luteolin diglucuronide and APIGENIN diglucuronide obtained from Perilla nankinensis
821. Dietary flavonoid APIGENIN is not effective in preventing development of a bleomycin-induced murine model of scleroderma
822. 3-C-(6 ″’-O-Acetyl-β-cellobiosyl) APIGENIN, a New Flavonoid from Pteris vittata
823. Effect of APIGENIN on the Proliferation and Differentiation of 3T3-L1 Preadipocytes [J]
824. Protective effect of APIGENIN in acute cerebral injury of rats [J]
825. Total synthesis of 8-(1, 1-dimethylallyl)-APIGENIN
826. Effect of Kaempferol, APIGENIN on injury of mitochondria in H_2O_2-induced cardiomyocyte apoptosis [J]
827. Behavioural responses of Lymnaea acuminata against APIGENIN, morusin and quercetin in bait pellets
828. DETERMINATION OF APIGENIN, LUTEOLIN AND ISOQUERCITRIN BYCAPILLARY ZONE ELECTROPHORESIS [J]
829. Pharmacokinetics of luteolin and APIGENIN in rats after single oral administration of Chrysanthemum morifolium extract at the dose of effectiveness and approximate to …
830. Preparation and spectral characterization of APIGENIN molecularly imprinted polymer
831. A rapid densitometric method for the quantification of APIGENIN-7-glucoside in Euphorbia prostrata herb using HPTLC.
832. Inhibitory effects of APIGENIN on human ovarian cancer cell strain SKOV3 growth [J]
833. Antioxidant action of APIGENIN, quercetin-3, 3′-dimethyl etherhe and quercetagetin-3, 6-dimethyl ether-7-o-glucoside in vitro
834. Pharmacokinetics of APIGENIN solid lipid nanoparticles in rats
835. RP-HPLC simultaneous determination of luteolin, APIGENIN and kaempferol in Verbena oficinalis L.
836. Determination of APIGENIN in Leaves of large leaf water dropwort by HPLC
837. Effect of APIGENIN on SBP of spontaneous hypertension rats and its mechanism.
838. Evaluation of induced apoptosis of APIGENIN in 3 lines of human B cell lymphoma in vitro
839. Effect of APIGENIN on hepatic fibrosis induced by carbon tetrachloride in mice
840. Study on intestinal absorption kinetics of APIGENIN in rats
841. APIGENIN inhibits TNFα-induced cell proliferation in endometriotic stromal cells
842. Effects of kaempferol, APIGENIN and daidzein on H_2O_2-induced apoptosis in neonatal rat cardiomyocytes [J]
843. Study on pro-apoptotic effect of APIGENIN on human ovarian cancer cells and its underlying mechanisms
844. Determination of the concentration of APIGENIN in rat plasma and bile by HPLC method
845. Induction of differentiation of Hep G2 cells by APIGENIN
846. Targeting TSP1 and inhibiting angiogenesis in UV-induced skin cancer by APIGENIN.
847. The Protection of APIGENIN on Autoimmune Hepatitis in Mice [J]
848. The Protective Effect of APIGENIN on Hepatic Ischemia Reperfusion Injury in Rats
849. APIGENIN enhances gemcitabine-induced pancreatic cancer cell apoptosis
850. Protective effects of APIGENIN against methyl methanesulfonate induced hsp70 expression in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ …
851. APIGENIN induces p53-dependent apoptosis and G 2/M arrest in breast cancer T47D cells
852. APIGENIN Delays the Senescence of Human Umbilical Vein Endothelial Cells in Vitro [J]
853. HPLC determination of luteolin and APIGENIN in rat bile and its application
854. Effect of APIGENIN on matrix metall-oproteinases and CD44v6 in human colon cancer cell SW480
855. Effects of APIGENIN on membrane potential in the liverwort Conocephalum conicum
856. Effect of Lateral Ventricle Injection of APIGENIN on Ovary Function of Female Rats during Estrus
857. APIGENIN augments the therapeutic efficacy in vitro in thymidine kinase gene system on prostate cancer
858. APIGENIN inhibits the expression of VEGF in human breast cancer cells named MDA-MB-231 [J]
859. APIGENIN Derivatives of Paulownia coreana Uyeki Leaves
860. EFFECT OF APIGENIN ON EXPRESSION OF NF-κB AND ICAM-1 IN RAT MYOCARDIUM WITH ISCHEMIA REPERFUSION [J]
861. HPLC determination of luteolin and APIGENIN in Siphonostegia chinensis
862. Effects of APIGENIN on the Proliferation and Cytokine Gene Expression of Murine T Lymphocytes [J]
863. Biokonverzija APIGENIN-7-O-β-glukozida u vodenom dvofaznom sistemu
864. In vivo radioprotective effect of curcumin, taurine, APIGENIN and kampferol on DNA damage in mouse
865. Effect of APIGENIN on Early Cognition of Rats with Ischemic Hypoxia Neonatal Brain Damage
866. Anti-inflammatory Effect of APIGENIN on Microglia after Oxygen Glucose Deprivation and Reperfusion
867. Studies on pharmacy characters and pharmacokinetics of oral APIGENIN loaded solid lipid nanoparticle
868. Induction of apoptosis through up-regulating PTEN in human hepatocellular carcinoma HepG2 cell line by APIGENIN
869. Plant flavonoid APIGENIN inhibits prostate carcinogenesis by suppressing β-catenin signaling pathways
870. Determination of Luteolin and APIGENIN in Chrysanthemum morifolium Extract by RP-HPLC [J]
871. APIGENIN-mediated modulations of PI3K-Akt and MAPK signaling pathways causes growth Inhibition and cell cycle arrest in human prostate cancer cells
872. Determination of the Contents of Lomefloxacin Hydrochloridum, Quercetin and APIGENIN in Propolis from Different Production Areas by HPLC
873. Enzymatic Synthesis of APIGENIN Glucosides by Glucosyltransferase (YjiC) from Bacillus licheniformis DSM 13
874. Suppression of early colon cancer lesions by APIGENIN and naringenin is in part due to their downregulation of p21, TLR‐4, and MCT‐1 expression
875. High-performance liquid chromatography for determination of psoralene, bergapten and APIGENIN in Ficus hirta Vahl
876. Effect of APIGENIN on the Expression of NF-κB and iNOS in Transient Focal Cerebral Ischemia and Reperfusion Model of Rats
877. Insight into the mechanisms by which APIGENIN, curcumin and sulfasalazine induce apoptosis in colon cancer cells
878. The Pattern of Accumulation of APIGENIN in the Ligulate Flowers of Chamomilla recutita in Extremely Varying Ecological Conditions
879. Optimization of mobile phase condition by using HCI program for extracting luteolin and APIGENIN from celery
880. Inhibition of Viability and Induction of Apoptosis by APIGENIN via Induction of Glutathione Depletion in Human Hepatocellular Carcinoma Hep G2 Cell Line [J]
881. Dietary flavonoid APIGENIN sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand
882. APIGENIN INHIBITS HUMAN PANCREATIC CANCER CELL PROLIFERATION THROUGH G2/M CELL CYCLE ARREST.
883. Cell apoptotic determination by Annexin V-FITC assay in APIGENIN and rutin-induced cell death in breast cancer cells
884. Selectively Inhibition of Cell Viability and Induction of Apoptosis in Human Gastric Cancer BGC-823 Cell Line by APIGENIN [J]
885. Identification of APIGENIN metabolites in rat liver perfusate by column switching high performance liquid chromatography/electrospray ionization mass spectrometry
886. Modulation of AKT, ERK and Mcl-1 by APIGENIN sensitizes colon cancer cells to anti-tumor activities of ABT263.
887. Role of NADPH oxidase-mediated generation of reactive oxygen species in the APIGENIN-induced melanogenesis in B16 melanoma cells
888. APIGENIN inhibits TGF-beta-induced VEGF expression in human prostate carcinoma cells via Smad2/3 and Src/FAK/Akt signaling pathways
889. APIGENIN inhibits constitutive and TNFalpha-mediated NF-kappaB activation and induces apoptosis in human prostate carcinoma PC-3 cells: Correlation with NF …
890. HPLC determination of APIGENIN-7-O-β-D-neospheroside and APIGENIN-7-O-β-D-glucopyranoside in the leaves of Exochorda serratifolia S. Moore
891. Research progress in antitumor effect and its mechanism of APIGENIN
892. HPTLC densitometric quantification of glycyrrhizin, glycyrrhetinic acid, APIGENIN, kaempferol and quercetin from Glycyrrhiza glabra.
893. Dietary APIGENIN and naringenin protect against colon carcinogenesis by lowering high multiplicity aberrant crypt foci and enhancing apoptosis in azoxymethane …
894. Efficient synthesis of APIGENIN
895. Hypnosedative activity of P. alata and its correlation with APIGENIN
896. Effect of APIGENIN on Reproduction and Reproductive Endocrinology
897. Progress in anti-tumor mechanisms of APIGENIN.
898. Effect of 3-methyladenine on APIGENIN-induced autophagy and apoptosis in the breast cancer T47D cell line
899. APIGENIN biotransformation using microorganism
900. APIGENIN Biotransformation Using Microorganism
901. Cytotoxic effects of APIGENIN on multiple myeloma cells
902. Protective effect of APIGENIN in acute cerebral injury of rats
903. The anti-tumour effects of APIGENIN in neuroblastoma.
904. APIGENIN 4′-O-methyltransferase
905. Determination of Nuezhenide and APIGENIN 7-O-neohesperidoside in Shanxiangyuan tablets by HPLC
906. Determination of APIGENIN in Herba Spirodrlae by HPLC
907. Determination of the protein binding rates of APIGENIN with different kinds of plasma by HPLC
908. Metabolism of APIGENIN by rat intestinal flora
909. New APIGENIN Triosides From The Seeds of Syzygium aromaticum
910. APIGENIN-ask a busy flavone!
911. Study on Optimization of Complexing Condition between APIGENIN and Zinc by Orthogonal Design
912. Effect of APIGENIN on Proliferation and Metastasis of Cell Line MDA-MB-231
913. APIGENIN INHIBITS TNF-INDUCED CELL PROLIFERATION IN
914. The influence of APIGENIN on growth and apoptosis in prostate cancer cells
915. Determination of APIGENIN in chamomile by HPLC
916. Odredjivanje APIGENINa i APIGENIN 7-0-beta-glukozida u jezicastim cvetovima kamilice [Matricaria chamomilla].
917. The inhibitory effects of APIGENIN in the in vitro activation and proliferation of mouse lymphocytes
918. Molecular mechanism of APIGENIN induced apoptosis in leukemia
919. Vasorelaxation and Antiproliferation of APIGENIN
920. Effects of APIGENIN on HeLa Cell Growth in Vitro [J]
921. The Effect of APIGENIN on Gram Positives and Negative Bacteria
922. Src kinase is a novel target for anti-skin inflammation of APIGENIN
923. Study on metabolism of APIGENIN from celery leaf in human
924. Effects of APIGENIN on H_2O_2-induced Apoptosis in Melanocytes
925. The inhibitory effects of APIGENIN in the in vitro activation and proliferation of mouse lymphocytes
926. Experimental research of the effect of APIGENIN on the biological activity of human colon cancer cell line Lovo and its mechanism in vitro
927. In-vitro glycosylation of APIGENIN by YjiC from Bacillus licheniformis
928. Effect of APIGENIN on cell cycle of spermatogenic cells of male mice.
929. Evaluation of induced apoptosis of APIGENIN in 3 lines of human B cell lymphoma in vitro
930. APIGENIN Induces Apoptosis in Primary Effusion Lymphoma.
931. The Therapeutic Efficacy of APIGENIN in a Murine Model of Scleroderma
932. Determination of Psoralen and APIGENIN in Radix Fici Hirtae by HPLC
933. Determination of APIGENIN in corn silk by HPLC
934. Determination of APIGENIN in Celery by Dansyl chloride Fluorescence Quenching Spectrophotometry
935. Effects of APIGENIN on the pharmacokinetics of nimodipine in rats
936. The inhibitory effect of APIGENIN associated with cytoxan on mice inoculated with cervical cancer cell (U14)
937. The effects of APIGENIN on the recovery of neurological function following focal cerebral ischemia and reperfusion
938. Labeling of APIGENIN with {sup 131} I and bioactivity of {sup 131} I-APIGENIN in male and female rats
939. Effect and mechanism of APIGENIN on in vitro maturation of Xenopus oocytes
940. APIGENIN-induced apoptosis of bladder cancer cell BIU-87 and its mechanism
941. Effect of APIGENIN on hippocampus neuron injury induced by A?-amyloid 25-35
942. APIGENIN Protects Normal Blood Cells Against Adriamycin-Induced Injury Depending on Antioxidative Action
943. Inhibitory effect of APIGENIN on human Tenon capsule fibroblasts
944. APIGENIN potassium: a promising molecule for radiation protection
945. Study on Inclusion Compound of APIGENIN with Hydroxypropyl-β-Cyclodextrin [J]
946. APIGENIN inactivates Akt to trigger apoptosis in human prostate cancer cells
947. Study on the APIGENIN of Antitumor Chinese Herbal Herb FLOS BUDDLEJAE [J]
948. THE GROWTH INHIBITION AND APOPTOSIS-INDUCING EFFECTS OF APIGENIN IN HUMAN GASTRIC CARCINOMA CELLS
949. Effect of APIGENIN on CIK Cells Killing Colonic Cancer SW1116 Cells
950. Determination of Quercetin and APIGENIN in Verbena officinals from different regions and different times
951. Roles for Flavonoid APIGENIN in Regulation of the Mammalian Stress Response
952. APIGENIN inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of Protein Kinase C δ Tyr311
953. Effects of APIGENIN, a Flavonoid, on the Bioavailability of Tamoxifen in Rats
954. APIGENIN inhibition on alpha glucosidase in mice intestinal
955. Protective Effect of APIGENIN on Human Umbiliacal Vein Cells Injuries Induced by Homocysteine
956. Preparation and Characterization of APIGENIN-loaded Lipid Nanocapsules
957. Preparation and in vitro release test of APIGENIN-loaded chitosan microspheres [J]
958. Involvement of early growth response gene 1 (EGR-1) in growth suppression of the human colonic tumor cells by APIGENIN and its derivative isovitexin
959. Evaluation of topical delivery properties of APIGENIN in different vehicles and the implications in skin cancer prevention
960. Synthesis and Anti-hepatoma Activities of APIGENIN etherified and brominated derivatives
961. Determination of APIGENIN content from celery by high performance liquid chromatography (HPLC)
962. Isolation of APIGENIN From Trigonella foenum Graecum Seed Extract Using Column Chromatograpy on Lab Scale
963. The molecular mechanism (s) of skin chemoprevention by the plant flavonoid APIGENIN
964. Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of APIGENIN human targets
965. Structural analysis of lipopolysaccharides from Sinorhizobium sp. NGR234 induced by APIGENIN
966. Mechanism for APIGENIN complexing with cellular phosphatidylcholine
967. APIGENIN glucosides in tetraploid bisabolol variety of camomile
968. APIGENIN enhances the proliferative inhibition effect of aspirin in colon cancer cells by inhibiting COX-2
969. APIGENIN intake regulates Fox ‘O’signaling in an autochthonous mouse model of prostate cancer
970. Effects of APIGENIN on H2O2-induced apoptosis in melanocytes.
971. Evaluating the Inhibitory Activity of APIGENIN Extracted from Salvia officinalis leaves on the Growth of L20B Cancer Cell Line
972. Effect of APIGENIN on Learning Ability of Senile Mice Induced by D-Galactose
973. Growth inhibitory effects of gemcitabine are augmented by the flavonoid APIGENIN in human pancreatic cancer cells
974. Radiolabeling of APIGENIN with 131I and biodistribution in rats
975. Effect of APIGENIN on P38MAPK in Partial Cerebral Tissues of Intermittent Hypoxia Weanling Rats
976. APIGENIN INHIBITS GLUTAMATE-INDUCED CALCIUM SIGNALING IN CULTURED RAT HIPPOCAMPAL NEURONS
977. Electrochemical research on the APIGENIN of antitumor Chinese medicinal herb FLOS BUDDLEJAE.
978. APIGENIN-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation
979. Effect of APIGENIN on SOD, GSH-Px, CAT Activities in Male Mice Liver
980. UVB-induced apoptosis in keratinocytes is enhanced by the chemopreventive bioflavonoid APIGENIN.
981. APIGENIN-induced cell cycle arrest at G2/M in human colon cancer cells
982. The killing effect and its mechanism about C6 lines transfected with TK gene after treated with APIGENIN/GCV after in vitro
983. Induction of caspase-dependent, p53-mediated apoptosis by APIGENIN in 22Rv1 athymic nude mice tumor xenograft
984. APIGENIN, a chemopreventive flavonoid, enhances p53 expression through RNA-binding protein HuR
985. APIGENIN regulates prostate cancer matrix composition and cell attachment through an integrin alpha 1 dependent pathway
986. APIGENIN intake suppresses IGF-I signaling in an autochthonous mouse model of prostate cancer
987. Impact of APIGENIN on ovarian granulosa cell apoptosis in female rats
988. Role of Membrane Ion Transporters in the APIGENIN-Induced Melanogenesis in B16 Melanoma Cells
989. Inhibition of prostate carcinogenesis in TRAMP mice by oral intake of plant flavonoid APIGENIN
990. Effect of glycogen synthase kinase‐3B inhibition by APIGENIN on markers of proliferation, inflammation and apoptosis in pancreatic cancer
991. Synthesis and anti-multidrug resistant Staphylococcuc aureus (MRSA) activity of alkylated APIGENIN
992. Combinatory effects of the bioflavonoid APIGENIN with chemotherapeutic drugs on prostate, colon, and lung cancer cell lines
993. The effects of APIGENIN on proteoglycan synthesis in the human lumbar discs under hydrostatic pressure
994. Role of glutathione depletion in APIGENIN-induced apoptosis of osteogenic sarcoma MG-63 cell line in vitro [J]
995. APIGENIN down-regulates constitutive activation of AKT and induces apoptosis in primary effusion lymphoma cells
996. Abstract C7: Inhibitory effects of flavonoid APIGENIN by oral administration on angiogenesis of ovarian cancer through decrease VEGF expression in mouse model.
997. APIGENIN: Chemopreventive and chemotherapeutic potential for progestin-dependent breast cancer
998. Mechanism study of APIGENIN inducing apoptosis of human ovarian cancer cells through inhibiting protein kinase B activity
999. Effect of the near UV radiation on the flavonoid content of APIGENIN and quercetol of the Ononis spinosa L.
1000. APIGENIN and quercetin promote ΔpH-dependent accumulation of IAA in membrane vesicles
1001. APIGENIN and naringenin favorably modulate aberrant crypt foci development and colonic cell cytokinetics
1002. The inhibitory effect of APIGENIN-O-7–D-glucuronopyranoside on esophagitis and gastritis in rats
1003. Inhibitory mechanism of rat aortic vascular smooth muscle cell proliferation by APIGENIN
1004. Complex effects of dietary APIGENIN on prevention of MPA-accelerated DMBA-induced mammary tumors in Sprague-Dawley rats.
1005. NANOSCALE MOLECULAR DYNAMICS SIMULATION OF ANTICANCER DRUGS, QUERCETIN AND APIGENIN IN A LIPID BILAYER MEMBRANE
1006. Sensitization of Human Ovarian Cancer CoC1 Cells to TRAIL-induced Apoptosis by APIGENIN
1007. Alfalfa (Medicugo sutiva L.) APIGENIN Glycosides and Their Effect on the Pea Aphid (Acyrthosiphon pisum)
1008. Determination of Vitexin and APIGENIN-7-O-β-D-Pyranglycu Ronide in Broussonetia papyrifera by HPLC
1009. Chromatographic analyses of matrine and APIGENIN for rodent tissue distribution studies
1010. HPLC [high pressure liquid chromatography] determination of APIGENIN and its glucosides in chamomile (Matricaria chamomilla L.)
1011. The Infusion of Intermittent Hypoxia on p38MAPK and UItrastructure Changes in Marginal Striatum of Weanling Rats and the Intervention Effects of APIGENIN
1012. Effect of APIGENIN on apoptotic rate and matrix metabolism of human nucleus pulposus cells cultured in vitro under hydrostatic pressure
1013. Study on Interaction between APIGENIN and Herring Sperm DNA by Acridine Orange as a Fluorescence Probe
1014. Inhibition of growth and induction of differentiation by APIGENIN, baicalein and quercetin in colon cancer cells
1015. APIGENIN Induces Alterations of Reactive Oxygen Species, Ca+2 and Mitochondria Membrane Potential in Human Lung Cancer H460 and A549 Cells
1016. Anti-Ulcer Effect of $ APIGENIN-7-O-{beta}-D-Glucuronide $ Isolated from Chrysanthemum morifolium Ramataelle
1017. APIGENIN prevents chemically-induced skin tumor formation and inhibits COX-2 expression and activity in SKH-1 mouse epidermis
1018. Potentiation of Human Cervical Cancer HeLa Cells to TRAIL-induced Apoptosis by APIGENIN
1019. Effects of APIGENIN on proteoglycan core protein’s gene expression in the human lumbar disc nucleus pulposus in response to hydrostatic pressure
1020. [61] UDP-apiose: 7-O-(β-d-glucosyl) APIGENIN apiosyltransferase from Parsley
1021. Protective effect of quercetin and APIGENIN on hydrogen peroxideinduced apoptosis in HeLa cells
1022. Chemopreventive Efficacy of APIGENIN against N-Nitrosodiethylamine-Induced and Phenobarbital-Promoted Experimental Hepatoma
1023. Differential modulation of cyclooxygenase (COX) enzymes by the two putative cancer chemopreventive flavones APIGENIN and tricin
1024. RP-HPLC-DAD determination of quercetin, luteolin and APIGENIN in Marchantia covoluta
1025. Content determination of vitexin and APIGENIN-7-O-β-D-pyranglycuronide in Broussonetia papyrifera leaves by HPLC.
1026. Effect of APIGENIN on Oxidative Stress Induced by Daidzein and Genistein in Hamster Ovary Cells
1027. APIGENIN and naringenin decrease cell number in a dose dependent manner in non‐transformed young adult mouse colonocytes (YAMC) but not in those expressing …
1028. APIGENIN blocks medroxyprogesterone acetate-dependent progression of BT-474 human breast tumor xenografts by inducing apoptosis
1029. APIGENIN, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansi…
1030. Flavones from marchantia convoluta: isolation of APIGENIN-7-O-Beta-D-glucuronide and 5-hydroxyl-7-methoxyl-2-methylchromone
1031. Antioxidant properties and five new phenylpropanoid esters of APIGENIN from Sideritis syriaca L
1032. Effect of parsley intake on urinary APIGENIN excretion, blood antioxidant enzymes and biomarkers for oxidative stress in humans.
1033. Thomas Jefferson University, Department of Pathology, Anatomy and Cell Biology, Oral Administration of APIGENIN Inhibits Metastasis through AKT/P70S6K1/MMP-9 …
1034. APIGENIN prevents development of progestin-accelerated 7, 12-dimethylbenz (a) anthracene (DMBA)-induced mammary tumors in Sprague-Dawley rats
1035. SIMULTANEOUS DETERMINATION OF LUTEOLIN AND QUERCETIN AND APIGENIN IN BIDENS TRIPARTITAA L. BY RP-HPLC
1036. APIGENIN induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt …
1037. Sensitization of Human Ovarian Cancer CoC1 Cells to TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis by APIGENIN [J]
1038. QS301. APIGENIN Potentiates Gemcitabine-Induced Growth Arrest of Pancreatic Cancer Cells Through Blocking of Gemcitabine-Induced Upregulation of Cell Cycle …
1039. Effect of APIGENIN, kaempferol and resveratrol on the expression of interleukin-1b and tumor necrosis factor-a genes in J774. 2 macrophages
1040. Fluorescence Spectroscopic Study on the Mechanism of Interaction of Bovine Serum Albumin with Luteolin, APIGENIN or Puerarin
1041. Bioassay-guided isolation of APIGENIN with GABA-benzodiazepine activity from Tanacetum parthenium
1042. APIGENIN and Kaempferol inhibit LPS‐induced inflammatory responses by regulating intracellular translocation of RNA‐binding protein HuR in macrophages
1043. Antiarthritic Activity of APIGENIN, Scutellarein and Pectinolinergenin Glycosides from Clerodendron inerme
1044. The changes in APIGENIN, luteolin and their-7-O-glucosides content during Herba millefolii (Achillea collina Becker ex. Rchb. var.’Alba’) onthogenesis.
1045. Effect of APIGENIN on the expression of microglia in penumbra and cerebral water content after focal cerebral ischemia-reperfusion injury in rats.
1046. Study on APIGENIN Quantitation Analysis from Celery Extractions by High-performance Liquid Chromatography (HPLC) and High-performance Lamina …
1047. Isolation of APIGENIN-7, 4′-Dimethylethers from Leaves of Aquilaria Sinensis (Lour.) Gilg by High-Speed Counter-Current Chromatography and Its Scavenging Effect …
1048. HPLC determination of quercetin, luteolin and APIGENIN inLamiophlomis rotata (Benth.) Kudo and its capsules
1049. Potent Suppressive Effect of Resveratrol and APIGENIN on Pro‐Inflammatory Responses in Lipopolysaccharide and IFN‐γ‐activated Microglia and Macrophages …
1050. KLF4 overexpression and APIGENIN treatment inhibited cell migration and induced apoptosis in human malignant neuroblastoma SK-N-DZ and IMR32 cells
1051. APIGENIN protects 7, 12-dimethylbenz (a) anthracene–induced chromosomal abnormalities and DNA damage in the bone marrow cells of golden Syrian hamsters
1052. GEMININ, A REPLICATION INHIBITOR PROTEIN, IS OVER-EXPRESSED IN PANCREATIC CANCER TISSUE AND APIGENIN AFFECTS REPLICATION BY DOWN …
1053. Knockdown of N-Myc and concurrent treatment with APIGENIN controlled growth of human malignant neuroblastoma cells having N-Myc amplification
1054. Genetic control of APIGENIN di-C-glycoside biosynthesis in bread wheat grain and their role as yellow pigments of Asian alkaline noodles.
1055. Abstract# 5116: 5-Fluorouracil combined with APIGENIN enhances anticancer activity through induction of apoptosis in human breast cancer MDA-MB-453 cells
1056. Abstract# 3089: APIGENIN Inhibits HGF-Promoted Invasive Growth and Metastasis in MDA-MB-231 Breast Cancer Cells
1057. Simultaneous isolation of catechin, epicatechin, rutin and APIGENIN from spearmint (Mentha spicata L.) leaves by supercritical carbon dioxide (SC-CO2) …
1058. … , and other constituents from the leaves of Ochroma pyramidale (balsa wood, Bombacaceae): preferred conformations of 8-CbD-glucopyranosyl-APIGENIN …
1059. Abstract# 2962: APIGENIN downregulates XIAP protein expression through HDAC1 in prostate cancer
1060. 1456: The Flavonoid APIGENIN Inhibits the Proliferation of Prostatic Stromal Cells by Cell Cycle Arrest in G1/S
1061. 270 APIGENIN DECREASES HEMIN-MEDIATED HEME OXYGENASE-1 INDUCTION
1062. 7-(3-benzyloxypropyl) APIGENIN, a novel cytotoxic flavone derivative
1063. Abstract# 2990: Inhibition of histone deacetylase by plant flavone APIGENIN: A novel mechanism of chemoprotection
1064. Abstract# 961: Anti-proliferative activity of APIGENIN in colorectal and breast cancer cells
1065. Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid APIGENIN is accompanied by Akt inhibition in human prostate carcinoma PC3-M …
1066. Suppression of neurotensin receptor type 1 expression and function by APIGENIN in human colorectal cancers involves protein kinase CK2/JNK pathway
1067. UVB-induced COX-2 transcription in mouse keratinocytes requires the Ebox, ATF/CRE and NF-IL6 responsive elements and is inhibited by the bioflavonoid APIGENIN.
1068. 3′-Hydroxylation of APIGENIN by a Membrane-Bound Enzyme of Primary Leaves of Secale cereale: Localization and Characterization
1069. 4-HPR and APIGENIN together suppressed autophagy and cell survival pathways to increase apoptosis in human malignant neuroblastoma SH-SY5Y cells
1070. The therapeutic potential of APIGENIN
1071. Health functionality of APIGENIN: A review
1072. APIGENIN in cancer therapy: anti-cancer effects and mechanisms of action
1073. APIGENIN: A current review on its beneficial biological activities
1074. APIGENIN as neuroprotective agent: Of mice and men
1075. APIGENIN: A dietary flavonoid with diverse anticancer properties
1076. APIGENIN and breast cancers: from chemistry to medicine
1077. Role of APIGENIN in cancer prevention via the induction of apoptosis and autophagy
1078. Potential role of flavonoids in treating chronic inflammatory diseases with a special focus on the anti-inflammatory activity of APIGENIN
1079. Enhanced in vitro and in vivo skin deposition of APIGENIN delivered using ethosomes
1080. Flavonoid APIGENIN inhibits lipopolysaccharide-induced inflammatory response through multiple mechanisms in macrophages
1081. Pharmacokinetic properties and drug interactions of APIGENIN, a natural flavone
1082. Inhibition of PI3K/Akt/mTOR pathway by APIGENIN induces apoptosis and autophagy in hepatocellular carcinoma cells
1083. Plant flavone APIGENIN: An emerging anticancer agent
1084. APIGENIN inhibits renal cell carcinoma cell proliferation
1085. The significant impact of APIGENIN on different aspects of autoimmune disease
1086. Anti-inflammatory effects of APIGENIN in lipopolysaccharide-induced inflammatory in acute lung injury by suppressing COX-2 and NF-kB pathway
1087. Isolation of APIGENIN from subcritical water extracts: Optimization of the process
1088. Antibacterial attributes of APIGENIN, isolated from Portulaca oleracea L.
1089. A review on flavonoid APIGENIN: Dietary intake, ADME, antimicrobial effects, and interactions with human gut microbiota
1090. Inhibitory mechanism of APIGENIN on α-glucosidase and synergy analysis of flavonoids
1091. Probing into therapeutic anti-cancer potential of APIGENIN: recent trends and future directions
1092. Neuroprotective effect of APIGENIN in rats after contusive spinal cord injury
1093. Protective effect of APIGENIN against oxidative stress-induced damage in osteoblastic cells
1094. Insights into novel anticancer applications for APIGENIN.
1095. APIGENIN induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells
1096. APIGENIN suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells
1097. APIGENIN in the regulation of cholesterol metabolism and protection of blood vessels
1098. The flavonoid APIGENIN inhibits hepatitis C virus replication by decreasing mature microRNA122 levels
1099. Inhibition of the STAT3 signaling pathway contributes to APIGENIN-mediated anti-metastatic effect in melanoma
1100. APIGENIN: A natural bioactive flavone-type molecule with promising therapeutic function
1101. APIGENIN-7-O-glucoside versus APIGENIN: Insight into the modes of anticandidal and cytotoxic actions
1102. APIGENIN-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells
1103. The effects of APIGENIN on lipopolysaccharide-induced depressive-like behavior in mice
1104. APIGENIN loaded nanoparticle delayed development of hepatocellular carcinoma in rats
1105. Curcumin and APIGENIN–novel and promising therapeutics against chronic neuroinflammation in Alzheimer’s disease
1106. APIGENIN attenuates doxorubicin induced cardiotoxicity via reducing oxidative stress and apoptosis in male rats
1107. APIGENIN induced MCF‐7 cell apoptosis‐associated reactive oxygen species
1108. APIGENIN induces cell shrinkage in Candida albicans by membrane perturbation
1109. Combination therapy of LysGH15 and APIGENIN as a new strategy for treating pneumonia caused by Staphylococcus aureus
1110. Resveratrol as a bioenhancer to improve anti-inflammatory activities of APIGENIN
1111. APIGENIN inhibits African swine fever virus infection in vitro
1112. APIGENIN sensitizes hepatocellular carcinoma cells to doxorubic through regulating miR-520b/ATG7 axis
1113. APIGENIN suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects
1114. APIGENIN pretreatment enhances growth and salinity tolerance of rice seedlings
1115. Protective effect of APIGENIN on ischemia/reperfusion injury of the isolated rat heart
1116. APIGENIN inhibits IL-6 transcription and suppresses esophageal carcinogenesis
1117. APIGENIN suppresses the stem cell-like properties of triple-negative breast cancer cells by inhibiting YAP/TAZ activity
1118. APIGENIN and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats
1119. Formulation and characterization of an APIGENIN-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential
1120. APIGENIN inhibits growth of breast cancer cells: the role of ERα and HER2/neu
1121. Protective effect of APIGENIN against N-nitrosodiethylamine (NDEA)-induced hepatotoxicity in albino rats
1122. Antitumor and anti-invasive effect of APIGENIN on human breast carcinoma through suppression of IL-6 expression
1123. Neuroprotective and neurotrophic effects of APIGENIN and Luteolin in MPTP induced parkinsonism in mice
1124. Protective role of APIGENIN in cisplatin-induced renal injury
1125. Deep eutectic solvent-based microwave-assisted extraction of genistin, genistein and APIGENIN from pigeon pea roots
1126. Dietary APIGENIN reduces LPS‐induced expression of miR‐155 restoring immune balance during inflammation
1127. Exposure of breast cancer cells to a subcytotoxic dose of APIGENIN causes growth inhibition, oxidative stress, and hypophosphorylation of Akt
1128. Neuroprotective effects of APIGENIN against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease
1129. Enhanced bioavailability of APIGENIN via preparation of a carbon nanopowder solid dispersion
1130. The flavonoid APIGENIN reduces prostate cancer CD44+ stem cell survival and migration through PI3K/Akt/NF-κB signaling
1131. Protective effects of APIGENIN and myricetin against cisplatin-induced nephrotoxicity in mice
1132. Modulation of thyroidal radioiodide uptake by oncological pipeline inhibitors and APIGENIN
1133. Anti-inflammatory effect of APIGENIN on LPS-induced pro-inflammatory mediators and AP-1 factors in human lung epithelial cells
1134. APIGENIN inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway
1135. APIGENIN blocks IKKα activation and suppresses prostate cancer progression
1136. Biosynthesis of two flavones, APIGENIN and genkwanin, in Escherichia coli
1137. APIGENIN potentiates the growth inhibitory effects by IKK-β-mediated NF-κB activation in pancreatic cancer cells
1138. Inhibition of mTOR by APIGENIN in UVB-irradiated keratinocytes: a new implication of skin cancer prevention
1139. APIGENIN suppresses colorectal cancer cell proliferation, migration and invasion via inhibition of the Wnt/β-catenin signaling pathway
1140. APIGENIN retards atherogenesis by promoting ABCA1-mediated cholesterol efflux and suppressing inflammation
1141. APIGENIN restricts FMDV infection and inhibits viral IRES driven translational activity
1142. Plant flavone APIGENIN binds to nucleic acid bases and reduces oxidative DNA damage in prostate epithelial cells
1143. Oxidative stress triggered by APIGENIN induces apoptosis in a comprehensive panel of human cervical cancer-derived cell lines
1144. Inhibition of glutamine utilization sensitizes lung cancer cells to APIGENIN-induced apoptosis resulting from metabolic and oxidative stress
1145. APIGENIN inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells
1146. Protective effects of APIGENIN against furan-induced toxicity in mice
1147. Analysis of the erythroid differentiation effect of flavonoid APIGENIN on K562 human chronic leukemia cells
1148. A comprehensive assessment of APIGENIN as an antiproliferative, proapoptotic, antiangiogenic and immunomodulatory phytocompound
1149. APIGENIN Inhibits Enterovirus-71 Infection by Disrupting Viral RNA Association with trans-Acting Factors
1150. The substituent effect on the radical scavenging activity of APIGENIN
1151. APIGENIN inhibits NF-κB and snail signaling, EMT and metastasis in human hepatocellular carcinoma
1152. APIGENIN reverses depression-like behavior induced by chronic corticosterone treatment in mice
1153. Sustainability and antimicrobial assessments of APIGENIN based polybenzoxazine film
1154. The effects of APIGENIN-biosynthesized ultra-small platinum nanoparticles on the human monocytic THP-1 cell line
1155. APIGENIN as an anti-quinolone-resistance antibiotic
1156. Activity of the dietary flavonoid, APIGENIN, against multidrug-resistant tumor cells as determined by pharmacogenomics and molecular docking
1157. APIGENIN, a natural flavonoid, attenuates EAE severity through the modulation of dendritic cell and other immune cell functions
1158. APIGENIN inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer
1159. APIGENIN ameliorates chronic mild stress-induced depressive behavior by inhibiting interleukin-1β production and NLRP3 inflammasome activation in the rat brain
1160. APIGENIN inhibits osteoblastogenesis and osteoclastogenesis and prevents bone loss in ovariectomized mice
1161. APIGENIN enhances the cisplatin cytotoxic effect through p53‑modulated apoptosis
1162. APIGENIN ameliorates HFD-induced NAFLD through regulation of the XO/NLRP3 pathways
1163. Effect of APIGENIN isolated from Aster yomena against Candida albicans: APIGENIN-triggered apoptotic pathway regulated by mitochondrial calcium signaling
1164. APIGENIN, a dietary flavonoid, inhibits proliferation of human bladder cancer T-24 cells via blocking cell cycle progression and inducing apoptosis
1165. Inhibition of Epstein-Barr virus reactivation by the flavonoid APIGENIN
1166. Antioxidative and protective actions of APIGENIN in a paracetamol-induced hepatotoxicity rat model
1167. The natural flavonoid APIGENIN sensitizes human CD44+ prostate cancer stem cells to cisplatin therapy
1168. APIGENIN alleviates STZ-induced diabetic cardiomyopathy
1169. Oxidative stress triggered by naturally occurring flavone APIGENIN results in senescence and chemotherapeutic effect in human colorectal cancer cells
1170. APIGENIN inhibits pancreatic stellate cell activity in pancreatitis
1171. Studies on the interaction of APIGENIN with calf thymus DNA by spectroscopic methods
1172. The flavonoid compound APIGENIN prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity
1173. APIGENIN reduces survival of choriocarcinoma cells by inducing apoptosis via the PI3K/AKT and ERK1/2 MAPK pathways
1174. APIGENIN induces ROS‐dependent apoptosis and ER stress in human endometriosis cells
1175. APIGENIN ameliorates dyslipidemia, hepatic steatosis and insulin resistance by modulating metabolic and transcriptional profiles in the liver of high-fat diet-induced …
1176. In vitro and in vivo anti-tumoral effects of the flavonoid APIGENIN in malignant mesothelioma
1177. APIGENIN inhibits colonic inflammation and tumorigenesis by suppressing STAT3-NF-κB signaling
1178. APIGENIN as an effective anticancer natural product: Spotlight on TRAIL, WNT/β‐catenin, JAK‐STAT pathways, and microRNAs
1179. Intraperitoneal administration of APIGENIN in liver ischemia/reperfusion injury protective effects
1180. Probing the potential of APIGENIN liposomes in enhancing bacterial membrane perturbation and integrity loss
1181. APIGENIN inhibits PMA-induced expression of pro-inflammatory cytokines and AP-1 factors in A549 cells
1182. APIGENIN induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70–Bax interaction in prostate cancer
1183. Anti-oxidant and anti-inflammatory effects of APIGENIN in a rat model of sepsis: an immunological, biochemical, and histopathological study
1184. Study on the pulmonary delivery system of APIGENIN-loaded albumin nanocarriers with antioxidant activity
1185. Effect of APIGENIN on Leishmania amazonensis Is Associated with Reactive Oxygen Species Production Followed by Mitochondrial Dysfunction
1186. Protective role of APIGENIN on rotenone induced rat model of Parkinson’s disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis
1187. APIGENIN impacts the growth of the gut microbiota and alters the gene expression of Enterococcus
1188. APIGENIN promotes osteogenic differentiation of human mesenchymal stem cells through JNK and p38 MAPK pathways
1189. APIGENIN inhibits the self-renewal capacity of human ovarian cancer SKOV3‑derived sphere-forming cells
1190. APIGENIN attenuates adriamycin-induced cardiomyocyte apoptosis via the PI3K/AKT/mTOR pathway
1191. Activation of PPARγ by a natural flavonoid modulator, APIGENIN ameliorates obesity-related inflammation via regulation of macrophage polarization
1192. APIGENIN attenuates oxidative injury in ARPE-19 cells thorough activation of Nrf2 pathway
1193. Protective effect of APIGENIN on Freund’s complete adjuvant-induced arthritis in rats via inhibiting P2X7/NF-κB pathway
1194. APIGENIN 7-glucoside from Stachys tibetica Vatke and its anxiolytic effect in rats
1195. Intestinal anti-inflammatory activity of APIGENIN K in two rat colitis models induced by trinitrobenzenesulfonic acid and dextran sulphate sodium
1196. Mushroom (Agaricus bisporus) polyphenoloxidase inhibited by APIGENIN: Multi-spectroscopic analyses and computational docking simulation
1197. Dual drug loaded liposome bearing APIGENIN and 5-Fluorouracil for synergistic therapeutic efficacy in colorectal cancer
1198. APIGENIN inhibits epithelial-mesenchymal transition of human colon cancer cells through NF-κB/Snail signaling pathway
1199. APIGENIN promotes TRAIL-mediated apoptosis regardless of ROS generation
1200. Solvent effects on the intramolecular hydrogen-bond and anti-oxidative properties of APIGENIN: A DFT approach
1201. APIGENIN alleviates endotoxin-induced myocardial toxicity by modulating inflammation, oxidative stress, and autophagy
1202. APIGENIN reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P+ cells through epigenetics modifications
1203. Induction of NRF2‐mediated gene expression by dietary phytochemical flavones APIGENIN and luteolin
1204. APIGENIN ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways
1205. Isolation and Identification of a Flavone APIGENIN from Marine Red Alga Acanthophora spicifera with Antinociceptive and Anti-Inflammatory Activities
1206. Downregulation of NEDD9 by APIGENIN suppresses migration, invasion, and metastasis of colorectal cancer cells
1207. APIGENIN exerts anti-inflammatory effects in an experimental model of acute pancreatitis by down-regulating TNF-α
1208. APIGENIN induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells
1209. The apoptotic effect of APIGENIN on human gastric carcinoma cells through mitochondrial signal pathway
1210. Development and optimization of APIGENIN-loaded transfersomal system for skin cancer delivery: in vitro evaluation
1211. APIGENIN, a dietary flavonoid, induces apoptosis, DNA damage, and oxidative stress in human breast cancer MCF-7 and MDA MB-231 cells
1212. Dissolution and bioavailability improvement of bioactive APIGENIN using solid dispersions prepared by different techniques
1213. APIGENIN-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling
1214. Comparative evaluation of the effect of cyclodextrins and pH on aqueous solubility of APIGENIN
1215. APIGENIN restrains colon cancer cell proliferation via targeted blocking of pyruvate kinase M2-dependent glycolysis
1216. APIGENIN and its methylglyoxal-adduct inhibit advanced glycation end products-induced oxidative stress and inflammation in endothelial cells
1217. Development and characterization of a green procedure for APIGENIN extraction from Scutellaria barbata D. Don
1218. APIGENIN, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death
1219. The protective effect of APIGENIN on myocardial injury in diabetic rats mediating activation of the PPAR-γ pathway
1220. Oral efficacy of APIGENIN against cutaneous leishmaniasis: involvement of reactive oxygen species and autophagy as a mechanism of action
1221. Dietary APIGENIN exerts immune-regulatory activity in vivo by reducing NF-κB activity, halting leukocyte infiltration and restoring normal metabolic function
1222. APIGENIN overcomes drug resistance by blocking the signal transducer and activator of transcription 3 signaling in breast cancer cells
1223. APIGENIN attenuates experimental autoimmune myocarditis by modulating Th1/Th2 cytokine balance in mice
1224. APIGENIN enhances skeletal muscle hypertrophy and myoblast differentiation by regulating Prmt7
1225. APIGENIN, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation
1226. APIGENIN inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line
1227. APIGENIN inhibits cancer stem cell‐like phenotypes in human glioblastoma cells via suppression of c‐met signaling
1228. APIGENIN accumulation and expression analysis of APIGENIN biosynthesis relative genes in celery
1229. Anti—chikungunya activity of luteolin and APIGENIN rich fraction from Cynodon dactylon
1230. APIGENIN induces the apoptosis and regulates MAPK signaling pathways in mouse macrophage ANA-1 cells
1231. APIGENIN mediated protection of OGD-evoked neuron-like injury in differentiated PC12 cells
1232. APIGENIN inhibits TGF‐β‐induced VEGF expression in human prostate carcinoma cells via a Smad2/3‐and Src‐dependent mechanism
1233. Effect of APIGENIN, kaempferol and resveratrol on the gene expression and protein secretion of tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) in RAW …
1234. Hydrogen-bonding interactions between APIGENIN and ethanol/water: a theoretical study
1235. APIGENIN and naringenin ameliorate PKCβII-associated endothelial dysfunction via regulating ROS/caspase-3 and NO pathway in endothelial cells exposed to high …
1236. APIGENIN potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependent manner
1237. Treatment of dermatophytosis by a new antifungal agent ‘APIGENIN‘
1238. Development and evaluation of injectable nanosized drug delivery systems for APIGENIN
1239. Induction of caspase-dependent apoptosis by APIGENIN by inhibiting STAT3 signaling in HER2-overexpressing MDA-MB-453 breast cancer cells
1240. APIGENIN inhibits TNFα/IL-1α-induced CCL2 release through IKBK-epsilon signaling in MDA-MB-231 human breast cancer cells
1241. APIGENIN and hesperidin augment the toxic effect of doxorubicin against HepG2 cells
1242. APIGENIN sensitizes BEL-7402/ADM cells to doxorubicin through inhibiting miR-101/Nrf2 pathway
1243. Effect of APIGENIN-7-glucoside, genkwanin and naringenin on tyrosinase activity and melanin synthesis in B16F10 melanoma cells
1244. APIGENIN protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene …
1245. APIGENIN inhibits the inducible expression of programmed death ligand 1 by human and mouse mammary carcinoma cells
1246. Plant-derived flavone APIGENIN: the small-molecule with promising activity against therapeutically resistant prostate cancer
1247. APIGENIN suppresses GLUT-1 and p-AKT expression to enhance the chemosensitivity to cisplatin of laryngeal carcinoma Hep-2 cells: an in vitro study
1248. APIGENIN attenuates oxidative stress and neuronal apoptosis in early brain injury following subarachnoid hemorrhage
1249. α-Mangostin and APIGENIN induced cell cycle arrest and programmed cell death in SKOV-3 ovarian cancer cells
1250. APIGENIN attenuates streptozotocin-induced pancreatic β cell damage by its protective effects on cellular antioxidant defense
1251. Shear rheology and in-vitro release kinetic study of APIGENIN from lyotropic liquid crystal
1252. Selective toxicity of APIGENIN on cancerous hepatocytes by directly targeting their mitochondria
1253. APIGENIN isolated from Daphne genkwa Siebold et Zucc. inhibits 3T3-L1 preadipocyte differentiation through a modulation of mitotic clonal expansion
1254. Targeted hyaluronic acid-based lipid nanoparticle for APIGENIN delivery to induce Nrf2-dependent apoptosis in lung cancer cells
1255. Utilizing spray drying technique to improve oral bioavailability of APIGENIN
1256. Anti-inflammatory effect of APIGENIN and hydroalcoholic extract of Dracocephalum kotschyi on acetic acid-induced colitis in rats
1257. APIGENIN mediated gold nanoparticle synthesis and their anti-cancer effect on human epidermoid carcinoma (A431) cells
1258. Mitigating effects of APIGENIN on edifenphos-induced oxidative stress, DNA damage and apoptotic cell death in human peripheral blood lymphocytes
1259. The effects of APIGENIN on the expression of Fas/FasL apoptotic pathway in warm liver ischemia-reperfusion injury in rats
1260. APIGENIN inhibits in vitro and in vivo tumorigenesis in cisplatin-resistant colon cancer cells by inducing autophagy, programmed cell death and targeting m-TOR …
1261. Fabrication of APIGENIN loaded gellan gum–chitosan hydrogels (GGCH-HGs) for effective diabetic wound healing
1262. APIGENIN and luteolin display differential hypocholesterolemic mechanisms in mice fed a high-fat diet
1263. Suppression of NF-κB and NF-κB-regulated gene expression by APIGENIN through IκBα and IKK pathway in TRAMP mice
1264. APIGENIN ameliorates hypertension-induced cardiac hypertrophy and down-regulates cardiac hypoxia inducible factor-lα in rats
1265. APIGENIN alleviates myocardial reperfusion injury in rats by downregulating miR-15b
1266. APIGENIN inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway
1267. APIGENIN produced by maize flavone synthase I and II protects plants against UV‐B‐induced damage
1268. The flavones APIGENIN and luteolin induce FOXO1 translocation but inhibit gluconeogenic and lipogenic gene expression in human cells
1269. APIGENIN suppresses the apoptosis of H9C2 rat cardiomyocytes subjected to myocardial ischemia‑reperfusion injury via upregulation of the PI3K/Akt pathway
1270. APIGENIN protects blood–brain barrier and ameliorates early brain injury by inhibiting TLR4-mediated inflammatory pathway in subarachnoid hemorrhage rats
1271. APIGENIN prevents metabolic syndrome in high-fructose diet-fed mice by Keap1-Nrf2 pathway
1272. Solubility and thermodynamic parameters of APIGENIN in different neat solvents at different temperatures
1273. Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by APIGENIN contributes to repression of prostate cancer metastasis
1274. APIGENIN inhibits TGF-β1-induced proliferation and migration of airway smooth muscle cells
1275. APIGENIN suppresses mouse peritoneal fibrosis by down-regulating miR34a expression
1276. APIGENIN inhibits d-galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPARγ expressions in mice
1277. The natural plant flavonoid APIGENIN is a strong antioxidant that effectively delays peripheral neurodegenerative processes
1278. Oxidation pathways underlying the pro-oxidant effects of APIGENIN
1279. … of neuronal differentiation of murine N2a cells by two polyphenols present in the mediterranean diet mimicking neurotrophins activities: resveratrol and APIGENIN
1280. Extraction, purification, and hydrolysis behavior of APIGENIN-7-O-glucoside from Chrysanthemum morifolium tea
1281. APIGENIN inhibits the proliferation of adenoid cystic carcinoma via suppression of glucose transporter-1
1282. Dietary APIGENIN promotes lipid catabolism, thermogenesis, and browning in adipose tissues of HFD-Fed mice
1283. APIGENIN attenuates heart injury in lipopolysaccharide-induced endotoxemic model by suppressing sphingosine kinase 1/sphingosine 1-phosphate signaling pathway
1284. Efficacy of APIGENIN and miltefosine combination therapy against experimental cutaneous leishmaniasis
1285. APIGENIN inhibits glioma cell growth through promoting microRNA-16 and suppression of BCL-2 and nuclear factor-κB/MMP‑9
1286. APIGENIN causes biochemical modulation, GLUT4 and Cd38 alterations to improve diabetes and to protect damages of some vital organs in experimental …
1287. The flavonoid APIGENIN ameliorates cisplatin-induced nephrotoxicity through reduction of p53 activation and promotion of PI3K/Akt pathway in human renal …
1288. Attenuation of oxidative stress of erythrocytes by the plant-derived flavonoids vitexin and APIGENIN
1289. APIGENIN has anti-atrophic gastritis and anti-gastric cancer progression effects in Helicobacter pylori-infected Mongolian gerbils
1290. APIGENIN C-glycosides of Microcos paniculata protects lipopolysaccharide induced apoptosis and inflammation in acute lung injury through TLR4 signaling pathway
1291. An improved synthesis of APIGENIN
1292. APIGENIN exhibits protective effects in a mouse model of d-galactose-induced aging via activating the Nrf2 pathway
1293. Direct comparison of metabolic health effects of the flavonoids quercetin, hesperetin, epicatechin, APIGENIN and anthocyanins in high-fat-diet-fed mice
1294. APIGENIN inhibited hypoxia induced stem cell marker expression in a head and neck squamous cell carcinoma cell line
1295. APIGENIN attenuates β-receptor-stimulated myocardial injury via safeguarding cardiac functions and escalation of antioxidant defence system
1296. Preparation of inclusion complex of APIGENIN-hydroxypropyl-β-cyclodextrin by using supercritical antisolvent process for dissolution and bioavailability enhancement
1297. APIGENIN attenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediated mitochondrial dysfunction and caspase signal pathway
1298. Isolation, identification and characterization of APIGENIN from Justicia gendarussa and its anti-inflammatory activity
1299. APIGENIN attenuates atherogenesis through inducing macrophage apoptosis via inhibition of AKT Ser473 phosphorylation and downregulation of …
1300. Synthesis, nitric oxide release, and α-glucosidase inhibition of nitric oxide donating APIGENIN and chrysin derivatives
1301. APIGENIN attenuates melanoma cell migration by inducing anoikis through integrin and focal adhesion kinase inhibition
1302. The flavonoid APIGENIN is a progesterone receptor modulator with in vivo activity in the uterus
1303. Induction of caspase-dependent extrinsic apoptosis by APIGENIN through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in …
1304. Downregulating CD26/DPPIV by APIGENIN modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple …
1305. APIGENIN reverses lung injury and immunotoxicity in paraquat-treated mice
1306. Protective effects of APIGENIN against paraquat-induced acute lung injury in mice
1307. APIGENIN inhibits growth and migration of fibroblasts by suppressing FAK signaling
1308. A pH-sensitive microemulsion-filled gellan gum hydrogel encapsulated APIGENIN: Characterization and in vitro release kinetics
1309. APIGENIN inhibits HeLa sphere‑forming cells through inactivation of casein kinase 2α
1310. APIGENIN inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo
1311. APIGENIN ameliorates the obesity‐induced skeletal muscle atrophy by attenuating mitochondrial dysfunction in the muscle of obese mice
1312. Synergistic apoptotic effects of APIGENIN TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer
1313. APIGENIN inhibits enterovirus 71 replication through suppressing viral IRES activity and modulating cellular JNK pathway
1314. Antioxidant and photoprotective activity of APIGENIN and its potassium salt derivative in human keratinocytes and absorption in Caco-2 cell monolayers
1315. The antidepressant effects of APIGENIN are associated with the promotion of autophagy via the mTOR/AMPK/ULK1 pathway
1316. APIGENIN, a potent suppressor of dendritic cell maturation and migration, protects against collagen‐induced arthritis
1317. APIGENIN manipulates the ubiquitin–proteasome system to rescue estrogen receptor-β from degradation and induce apoptosis in prostate cancer cells
1318. Enhanced action of APIGENIN and naringenin combination on estrogen receptor activation in non-malignant colonocytes: Implications on sorghum-derived …
1319. The roles of synovial hyperplasia, angiogenesis and osteoclastogenesis in the protective effect of APIGENIN on collagen-induced arthritis
1320. Bioinformatics and in vitro experimental analyses identify the selective therapeutic potential of interferon gamma and APIGENIN against cervical squamous cell …
1321. Solubility determination and thermodynamic data of APIGENIN in binary {Transcutol®+ water} mixtures
1322. Cocrystal of APIGENIN with higher solubility, enhanced oral bioavailability, and anti-inflammatory effect
1323. APIGENIN-7-O-β-D-(-6”-p-coumaroyl)-Glucopyranoside treatment elicits neuroprotective effect against experimental ischemic stroke
1324. Polymethoxyflavone APIGENIN-trimethylether suppresses LPS-induced inflammatory response in nontransformed porcine intestinal cell line IPEC-J2
1325. APIGENIN inhibits UVB-induced skin carcinogenesis: the role of thrombospondin-1 as an anti-inflammatory factor
1326. Phenolic compounds APIGENIN, hesperidin and kaempferol reduce in vitro lipid accumulation in human adipocytes
1327. Therapeutic potential of APIGENIN, a plant flavonoid, for imatinib-sensitive and resistant chronic myeloid leukemia cells
1328. APIGENIN induces apoptosis by suppressing Bcl-xl and Mcl-1 simultaneously via signal transducer and activator of transcription 3 signaling in colon cancer
1329. APIGENIN protects against bleomycin‑induced lung fibrosis in rats
1330. Inhibition of autophagy ameliorates atherogenic inflammation by augmenting APIGENIN-induced macrophage apoptosis
1331. APIGENIN induces caspase-dependent apoptosis by inhibiting signal transducer and activator of transcription 3 signaling in HER2-overexpressing SKBR3 …
1332. Luteolin and APIGENIN attenuate 4-hydroxy-2-nonenal-mediated cell death through modulation of UPR, Nrf2-ARE and MAPK pathways in PC12 cells
1333. APIGENIN prevents ultraviolet-B radiation induced cyclobutane pyrimidine dimers formation in human dermal fibroblasts
1334. APIGENIN regulates interleukin-1β-induced production of matrix metalloproteinase both in the knee joint of rat and in primary cultured articular chondrocytes
1335. Transcriptome-based repurposing of APIGENIN as a potential anti-fibrotic agent targeting hepatic stellate cells
1336. Preventive effect of APIGENIN against isoproterenol‐induced apoptosis in cardiomyoblasts
1337. In silico approaches for investigating the binding propensity of APIGENIN and luteolin against class I HDAC isoforms
1338. Enhancing oral bioavailability using preparations of APIGENIN-loaded W/O/W emulsions: In vitro and in vivo evaluations
1339. APIGENIN attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats
1340. APIGENIN attenuates acrylonitrile-induced neuro-inflammation in rats: Involved of inactivation of the TLR4/NF-κB signaling pathway
1341. Chrysin, Abundant in Morinda citrifolia Fruit Water–EtOAc Extracts, Combined with APIGENIN Synergistically Induced Apoptosis and Inhibited Migration in Human …
1342. Anti-inflammatory and neuroprotective effect of APIGENIN: studies in the GFAP-IL6 mouse model of chronic neuroinflammation
1343. APIGENIN attenuates diabetes-associated cognitive decline in rats via suppressing oxidative stress and nitric oxide synthase pathway
1344. APIGENIN and luteolin attenuate the breaching of MDA-MB231 breast cancer spheroids through the lymph endothelial barrier in vitro
1345. APIGENIN attenuates edifenphos-induced toxicity by modulating ROS-mediated oxidative stress, mitochondrial dysfunction and caspase signal pathway in rat liver and …
1346. APIGENIN induced apoptosis in esophageal carcinoma cells by destruction membrane structures
1347. APIGENIN attenuates acute myocardial infarction of rats via the inhibitions of matrix metalloprotease-9 and inflammatory reactions
1348. Protective effects of APIGENIN against acrylonitrile-induced subchronic sperm injury in rats
1349. Improved solubility and oral bioavailability of APIGENIN via Soluplus/Pluronic F127 binary mixed micelles system
1350. APIGENIN protects the brain against ischemia/reperfusion injury via caveolin-1/VEGF in vitro and in vivo
1351. APIGENIN inhibits COX-2, PGE2, and EP1 and also initiates terminal differentiation in the epidermis of tumor bearing mice
1352. APIGENIN protects against renal tubular epithelial cell injury and oxidative stress by high glucose via regulation of NF-E2-related factor 2 (Nrf2) pathway
1353. Identification and Characterization of APIGENIN 6-C-Glucosyltransferase Involved in Biosynthesis of Isosaponarin in Wasabi (Eutrema japonicum)
1354. Development and validation of an HPTLC method for APIGENIN 7-O-glucoside in chamomile flowers and its application for fingerprint discrimination of chamomile-like …
1355. APIGENIN supplementation protects the development of dextran sulfate sodium-induced murine experimental colitis by inhibiting canonical and non-canonical …
1356. APIGENIN inhibits fibroblast proliferation and reduces epidural fibrosis by regulating Wnt3a/β-catenin signaling pathway
1357. APIGENIN attenuates PM2. 5-induced airway hyperresponsiveness and inflammation by down-regulating NF-κB in murine model of asthma
1358. APIGENIN attenuates hippocampal oxidative events, inflammation and pathological alterations in rats fed high fat, fructose diet
1359. … p53, stabilized by its interplay with HSP90, activates a positive feed-back loop between NRF2 and p62 that induces chemo-resistance to APIGENIN in pancreatic cancer …
1360. APIGENIN protects mice from pneumococcal pneumonia by inhibiting the cytolytic activity of pneumolysin
1361. Cirsium japonicum var. maackii and APIGENIN block Hif‐2α‐induced osteoarthritic cartilage destruction
1362. An ointment consisting of the phage lysin LysGH15 and APIGENIN for decolonization of methicillin-resistant Staphylococcus aureus from skin wounds
1363. APIGENIN potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms
1364. Fabrication, in-vitro characterization, and enhanced in-vivo evaluation of carbopol-based nanoemulsion gel of APIGENIN for UV-induced skin carcinoma
1365. Whole transcriptomic analysis of APIGENIN on TNFα immuno-activated MDA-MB-231 breast cancer cells
1366. The antiproliferative and apoptotic effects of APIGENIN on glioblastoma cells
1367. Dietary APIGENIN reduces induction of LOX-1 and NLRP3 expression, leukocyte adhesion, and acetylated low-density lipoprotein uptake in human endothelial cells …
1368. Comprehensive assessment of antioxidant activities of APIGENIN isomers: vitexin and isovitexin
1369. APIGENIN attenuates inflammation in experimentally induced acute pancreatitis-associated lung injury
1370. De novo biosynthesis of APIGENIN, luteolin, and eriodictyol in the actinomycete Streptomyces albus and production improvement by feeding and spore …
1371. Combined effect of APIGENIN and ferulic acid on frozen‐thawed boar sperm quality
1372. Resveratrol, piperine and APIGENIN differ in their NADPH-oxidase inhibitory and reactive oxygen species-scavenging properties
1373. Cytotoxicity and Anti-inflammatory Properties of APIGENIN-Derived Isolaxifolin
1374. APIGENIN: Selective CK2 inhibitor increases Ikaros expression and improves T cell homeostasis and function in murine pancreatic cancer
1375. Synergistic interactions of APIGENIN, naringin, quercetin and emodin on inhibition of 3T3-L1 preadipocyte differentiation and pancreas lipase activity
1376. Effect of APIGENIN on apoptosis induced by renal ischemia/reperfusion injury in vivo and in vitro
1377. Effects of APIGENIN pretreatment against renal ischemia/reperfusion injury via activation of the JAK2/STAT3 pathway
1378. APIGENIN, a natural flavonoid, inhibits glutamate release in the rat hippocampus
1379. APIGENIN-7-O-β-D-glucuronide inhibits LPS-induced inflammation through the inactivation of AP-1 and MAPK signaling pathways in RAW 264.7 macrophages and …
1380. Protective effects of APIGENIN against 3-MCPD-induced renal injury in rat
1381. Anti-inflammatory effect of an APIGENIN-Maillard reaction product in macrophages and macrophage-endothelial cocultures
1382. Mutual Interaction of Phenolic Compounds and Microbiota: Metabolism of Complex Phenolic APIGENIN-C- and Kaempferol-O-Derivatives by Human Fecal Samples
1383. Aptamer-conjugated APIGENIN nanoparticles to target colorectal carcinoma: a promising safe alternative of colorectal cancer chemotherapy
1384. The flavonoid APIGENIN delays forgetting of passive avoidance conditioning in rats
1385. Protective effects of APIGENIN against 1-methyl-4-phenylpyridinium ion‑induced neurotoxicity in PC12 cells
1386. APIGENIN inhibits ethanol-induced oxidative stress and LPS-induced inflammatory cytokine production in cultured rat hepatocytes
1387. Effects of the vegetable polyphenols epigallocatechin-3-gallate, luteolin, APIGENIN, myricetin, quercetin, and cyanidin in primary cultures of human retinal …
1388. APIGENIN induces dermal collagen synthesis via smad2/3 signaling pathway
1389. Chemopreventive APIGENIN controls UVB-induced cutaneous proliferation and angiogenesis through HuR and thrombospondin-1
1390. Nutritional preconditioning of APIGENIN alleviates myocardial ischemia/reperfusion injury via the mitochondrial pathway mediated by notch1/hes1
1391. APIGENIN-7-glycoside prevents LPS-induced acute lung injury via downregulation of oxidative enzyme expression and protein activation through inhibition of MAPK …
1392. Enhanced solubility and bioavailability of APIGENIN via preparation of solid dispersions of mesoporous silica nanoparticles
1393. Validation of a RP-HPLC-DAD method for chamomile (Matricaria recutita) preparations and assessment of the marker, APIGENIN-7-glucoside, safety and anti …
1394. Design, synthesis, and characterization of novel APIGENIN analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in …
1395. Protective effects of APIGENIN on LPS-induced endometritis via activating Nrf2 signaling pathway
1396. Protective effect of APIGENIN on acrylonitrile-induced inflammation and apoptosis in testicular cells via the NF-κB pathway in rats
1397. APIGENIN ameliorates post-stroke cognitive deficits in rats through histone acetylation-mediated neurochemical alterations
1398. Activation of TRPV4 by dietary APIGENIN antagonizes renal fibrosis in deoxycorticosterone acetate (DOCA)–salt-induced hypertension
1399. Effects of APIGENIN on experimental ischemia/reperfusion injury in the rat ovary
1400. Antitumor and radiosensitizing synergistic effects of APIGENIN and cryptotanshinone against solid Ehrlich carcinoma in female mice
1401. In Vitro Effect of APIGENIN and Danshen in Tibial Dyschondroplasia Through Inhibition of Heat-Shock Protein 90 and Vascular Endothelial Growth Factor Expressions …
1402. Pharmacokinetic drug interactions between APIGENIN, rutin and paclitaxel mediated by P-glycoprotein in rats
1403. Synergistic antibacterial effect of APIGENIN with β-lactam antibiotics and modulation of bacterial resistance by a possible membrane effect against methicillin resistant …
1404. APIGENIN in combination with Akt inhibition significantly enhances thyrotropin-stimulated radioiodide accumulation in thyroid cells
1405. APIGENIN combined with gefitinib blocks autophagy flux and induces apoptotic cell death through inhibition of HIF-1α, c-Myc, p-EGFR, and glucose metabolism …
1406. APIGENIN and quercetin ameliorate mitochondrial alterations by tunicamycin-induced ER stress in 3T3-L1 adipocytes
1407. Novel APIGENIN based small molecule that targets snake venom metalloproteases
1408. Involvement of GABAergic pathway in the sedative activity of APIGENIN, the main flavonoid from Passiflora quadrangularis pericarp
1409. The flavonoid APIGENIN from Croton betulaster Mull inhibits proliferation, induces differentiation and regulates the inflammatory profile of glioma cells
1410. APIGENIN inhibits IL-31 cytokine in human mast cell and mouse skin tissues
1411. APIGENIN, a plant flavone playing Noble roles in Cancer prevention via modulation of key cell signaling networks
1412. Clerodendrum petasites S. Moore: The therapeutic potential of phytochemicals, hispidulin, vanillic acid, verbascoside, and APIGENIN
1413. Eriocitrin and APIGENIN as new carbonic anhydrase VA inhibitors from a virtual screening of calabrian natural products
1414. Deciphering the molecular mechanisms sustaining the estrogenic activity of the two major dietary compounds zearalenone and APIGENIN in ER-positive breast cancer …
1415. APIGENIN enhances the antitumor effects of cetuximab in nasopharyngeal carcinoma by inhibiting EGFR signaling
1416. APIGENIN attenuates myocardial ischemia/reperfusion injury via the inactivation of p38 mitogen‑activated protein kinase
1417. APIGENIN suppresses the IL-1β-induced expression of the urokinase-type plasminogen activator receptor by inhibiting MAPK-mediated AP-1 and NF-κB signaling in …
1418. APIGENIN reduce lipoteichoic acid-induced inflammatory response in rat cardiomyoblast cells
1419. APIGENIN from Croton betulaster Müll restores the immune profile of microglia against glioma cells
1420. Angiogenic effects of APIGENIN on endothelial cells after hypoxia-reoxygenation via the caveolin-1 pathway
1421. Preparation, characterization and antitumor activity evaluation of APIGENIN nanoparticles by the liquid antisolvent precipitation technique
1422. The estrogenic effects of APIGENIN, phloretin and myricetin based on uterotrophic assay in immature Wistar albino rats
1423. Enhanced chemotherapeutic efficacy of APIGENIN liposomes in colorectal cancer based on flavone-membrane interactions
1424. Recovery of chicken growth plate by heat-shock protein 90 inhibitors epigallocatechin-3-gallate and APIGENIN in thiram-induced tibial dyschondroplasia
1425. Antispasmodic activity of APIGENIN and luteolin, two components of Dracocephalum kotschyi extract, on rat ileum contractions
1426. Natural plant flavonoid APIGENIN directly disrupts Hsp90/Cdc37 complex and inhibits pancreatic cancer cell growth and migration
1427. Expression pattern of NMDA receptors reveals antiepileptic potential of APIGENIN 8-C-glucoside and chlorogenic acid in pilocarpine induced epileptic mice
1428. AgFNS overexpression increase APIGENIN and decrease anthocyanins in petioles of transgenic celery
1429. Microwave-assisted simultaneous extraction of luteolin and APIGENIN from tree peony pod and evaluation of its antioxidant activity
1430. Ultrasonically enhanced extraction of luteolin and APIGENIN from the leaves of Perilla frutescens (L.) Britt. using liquid carbon dioxide and ethanol
1431. The stability and activity changes of APIGENIN and luteolin in human cervical cancer Hela cells in response to heat treatment and Fe2+/Cu2+ addition
1432. A System-Level Investigation into the Mechanisms of APIGENIN against Inflammation
1433. Discovery of xanthine oxidase inhibitors and/or α-glucosidase inhibitors by carboxyalkyl derivatization based on the flavonoid of APIGENIN
1434. APIGENIN alleviates TGF-β1-induced nasal mucosa remodeling by inhibiting MAPK/NF-kB signaling pathways in chronic rhinosinusitis
1435. Suppression of AKT potentiates synergistic cytotoxicity of APIGENIN with TRAIL in anaplastic thyroid carcinoma cells
1436. One-step phosphorylated poly (amide-amine) dendrimer loaded with APIGENIN for simultaneous remineralization and antibacterial of dentine
1437. Effects of potassium APIGENIN and verbena extract on the wound healing process of SKH‐1 mouse skin
1438. APIGENIN inhibits growth and induces apoptosis in human cholangiocarcinoma cells
1439. APIGENIN inhibits growth of the Plasmodium berghei and disrupts some metabolic pathways in mice
1440. APIGENIN reduces the excessive accumulation of lipids induced by palmitic acid via the AMPK signaling pathway in HepG2 cells
1441. Ethyl oleate food-grade O/W emulsions loaded with APIGENIN: Insights to their formulation characteristics and physico-chemical stability
1442. Synthesis and anti-cancer activities of APIGENIN derivatives
1443. Axl receptor tyrosine kinase is a novel target of APIGENIN for the inhibition of cell proliferation
1444. Novel APIGENIN-loaded sodium hyaluronate nano-assemblies for targeting tumor cells
1445. Photoprotective and antigenotoxic effects of the flavonoids APIGENIN, naringenin and pinocembrin
1446. Simultaneous determination of oleanolic acid, ursolic acid, quercetin and APIGENIN in Swertia mussotii Franch by capillary zone electrophoresis with running buffer …
1447. 5‐Fluorouracil combined with APIGENIN enhances anticancer activity through mitochondrial membrane potential (ΔΨm)‐mediated apoptosis in hepatocellular …
1448. Anti-inflammation and anti-fibrosis with PEGylated, APIGENIN loaded PLGA nanoparticles in chronic pancreatitis disease
1449. Simultaneous determination and pharmacokinetic study of quercetin, luteolin, and APIGENIN in rat plasma after oral administration of matricaria chamomilla l …
1450. Storage stability of sorghum phenolic extracts’ flavones luteolin and APIGENIN
1451. Suppression of rat and human androgen biosynthetic enzymes by APIGENIN: possible use for the treatment of prostate cancer
1452. Degradable poly (APIGENIN) polymer inhibits tumor cell adhesion to vascular endothelial cells
1453. Inhibitory effect of hydroalcoholic and flavonoids extracts of Dracocephalum kotschyi, and its components luteolin, APIGENIN and APIGENIN-4′-galactoside on intestinal …
1454. Food polyphenol APIGENIN inhibits the cytochrome P450 monoxygenase branch of the arachidonic acid cascade
1455. Inhibitory effect of APIGENIN on pharmacokinetics of venlafaxine in vivo and in vitro
1456. Impact of APIGENIN and kaempferol on human head and neck squamous cell carcinoma
1457. Isolation of a flavonoid, APIGENIN 7-O-glucoside, from Mentha longifolia (L.) Hudson subspecies longifolia and its genotoxic potency
1458. Olive leaf components APIGENIN 7-glucoside and luteolin 7-glucoside direct human hematopoietic stem cell differentiation towards erythroid lineage
1459. Evaluation of the neuroprotective, anticonvulsant, and cognition-improvement effects of APIGENIN in temporal lobe epilepsy: Involvement of the mitochondrial …
1460. Effect of saponins and APIGENIN mixtures on feeding behavior of the pea aphid, Acyrthosiphon pisum Harris
1461. Effects of C-glycosylation on anti-diabetic, anti-Alzheimer’s disease and anti-inflammatory potential of APIGENIN
1462. APIGENIN rich-Limonium duriusculum (de Girard) Kuntze promotes apoptosis in HCT116 cancer cells
1463. Anti-degenerative effect of APIGENIN, Luteolin and Quercetin on human keratinocyte and chondrocyte cultures: SAR evaluation
1464. Inhibiting GLUT-1 expression and PI3K/Akt signaling using APIGENIN improves the radiosensitivity of laryngeal carcinoma in vivo
1465. APIGENIN reduces the Toll-like receptor-4-dependent activation of NF-κB by suppressing the Akt, mTOR, JNK, and p38-MAPK
1466. P53 AND CYCLIN B1 MEDIATE APOPTOTIC EFFECTS OF APIGENIN AND RUTIN IN ERï¡+-BREAST CANCER MCF-7 CELLS
1467. APIGENIN naturally occurring flavonoids: occurrence and bioactivity
1468. Adsorption/desorption characteristics and enrichment of quercetin, luteolin and APIGENIN from Flos populi using macroporous resin
1469. Controlled release oral delivery of APIGENIN containing pellets with antioxidant activity
1470. APIGENIN, an Anticancer Active Compound Isolated from Macaranga gigantifolia Leaves
1471. β3-Adrenoreceptor activity limits APIGENIN efficacy in Ewing sarcoma cells: a dual approach to prevent cell survival
1472. The role of APIGENIN in testicular damage in experimental ischemia-reperfusion injury in rats
1473. APIGENIN-7-O-β-d-(-6 ″-p-coumaroyl)-glucopyranoside pretreatment attenuates myocardial ischemia/reperfusion injury via activating AMPK signaling
1474. LC-MS/MS method for the simultaneous quantification of luteolin, wedelolactone and APIGENIN in mice plasma using hansen solubility parameters for liquid-liquid …
1475. Antidiarrhoeal assessment of hydroalcoholic and hexane extracts of Dracocephalum kotschyi Boiss. and APIGENIN in mice
1476. APIGENIN-induced ABCC1-mediated efflux of glutathione from mature erythrocytes inhibits the proliferation of Plasmodium falciparum
1477. Synergistic antimicrobial activity of APIGENIN against oral pathogens
1478. In vitro photosafety and efficacy screening of APIGENIN, chrysin and beta-carotene for UVA and VIS protection
1479. Inhibition of MDA‐MB‐231 breast cancer cell proliferation and tumor growth by APIGENIN through induction of G2/M arrest and histone H3 acetylation‐mediated …
1480. A novel, highly-water-soluble APIGENIN derivative provides neuroprotection following ischemia in male rats by regulating the ERK/Nrf2/HO-1 pathway
1481. Luteolin and APIGENIN activate the Oct‐4/Sox2 signal via NFATc1 in human periodontal ligament cells
1482. Determination of luteolin and APIGENIN in herbs by capillary electrophoresis with diode array detection
1483. Application of molecular imaging technology in evaluating the inhibiting effect of APIGENIN in vivo on subcutaneous hepatocellular carcinoma
1484. APIGENIN inhibits sciatic nerve denervation–induced muscle atrophy
1485. In vitro and in vivo activities of flavonoids-APIGENIN, baicalin, chrysin, scutellarin-in regulation of hypertension-a review for their possible effects in pregnancy-induced …
1486. Synthetic investigation toward APIGENIN 5-O-glycoside camellianin B as well as the chemical structure revision
1487. Chrysin, APIGENIN and Acacetin Inhibit Tumor Necrosis Factor-Related Apoptosis—Inducing Ligand Receptor-1 (TRAIL-R1) on Activated RAW264. 7 Macrophages
1488. A cytotoxic C-glycosylated derivative of APIGENIN from the leaves of Ocimum basilicum var. thyrsiflorum
1489. Levels of APIGENIN and immunostimulatory activity of leaf extracts of bangunbangun (Plectranthus amboinicus Lour)
1490. APIGENIN inhibits tumor necrosis factor-α-induced production and gene expression of mucin through regulating nuclear factor-kappa B signaling pathway in …
1491. Dose-and time-dependent pharmacokinetics of APIGENIN trimethyl ether
1492. Protective effects of the APIGENIN-O/C-diglucoside saponarin from Gypsophila trichotoma on carbone tetrachloride-induced hepatotoxicity in vitro/in vivo in rats
1493. Food-derived compounds APIGENIN and luteolin modulate mRNA splicing of introns with weak splice sites
1494. The potential application of strategic released APIGENIN from polymeric carrier in pulmonary fibrosis
1495. Effects of friedelin on the intestinal permeability and bioavailability of APIGENIN
1496. New APIGENIN glycoside, polyphenolic constituents, anti-inflammatory and hepatoprotective activities of Gaillardia grandiflora and Gaillardia pulchella aerial …
1497. The therapeutic effects of APIGENIN and dexamethasone on 5‐fluorouracil‐induced oral mucositis–a pilot study using a Syrian hamster model
1498. APIGENIN and APIGENINidin isolates from the Sorghum bicolor leaf targets inflammation via cyclo‐oxygenase‐2 and prostaglandin‐E2 blockade
1499. Absorption Properties of Luteolin and APIGENIN in Genkwa Flos Using In Situ Single-Pass Intestinal Perfusion System in the Rat
1500. New cytotoxic APIGENIN derivatives from Selaginella doederleinii
1501. Synthesis and α-glucosidase inhibitory activity of chrysin, diosmetin, APIGENIN, and luteolin derivatives
1502. Synergistic effect of graphene oxide coated nanotised APIGENIN with paclitaxel (GO-NA/PTX): a ROS dependent mitochondrial mediated apoptosis in ovarian cancer
1503. APIGENIN oxidovanadium (IV) cation interactions. Synthesis, spectral, bovine serum albumin binding, antioxidant and anticancer studies
1504. Effect of APIGENIN on dendritic cells maturation and function in murine splenocytes
1505. Effect on oxidative stress, glucose uptake level and lipid droplet content by APIGENIN 7, 4′-dimethyl ether isolated from Piper longum L
1506. Effect of APIGENIN on protein expressions of PPARs in liver tissues of rats with nonalcoholic steatohepatitis
1507. Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by APIGENIN circumvent taxol resistance in ovarian cancer cells
1508. APIGENIN-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation
1509. APIGENIN-induced HIF-1α inhibitory effect improves abnormal glucolipid metabolism in AngⅡ/hypoxia-stimulated or HIF-1α-overexpressed H9c2 cells
1510. The functional characterization of a site-specific APIGENIN 4′-O-methyltransferase synthesized by the liverwort species Plagiochasma appendiculatum
1511. Molecular docking analysis of APIGENIN and quercetin from ethylacetate fraction of Adansonia digitata with malaria-associated calcium transport protein: An in …
1512. APIGENIN prevents TNF-α induced apoptosis of primary rat retinal ganglion cells
1513. The effect of Fusarium inoculation and fungicide application on concentrations of flavonoids (APIGENIN, kaempferol, luteolin, naringenin, quercetin, rutin …
1514. Anticalculi activity of APIGENIN and celery (Apium graveolens L.) extract in rats induced by ethylene glycol–ammonium chloride
1515. The inhibitory effect of APIGENIN on the agonist-induced regulation of vascular contractility via calcium desensitization-related pathways
1516. Comparative transcriptome analysis of celery leaf Blades identified an R2R3-MYB transcription factor that regulates APIGENIN metabolism
1517. Anti-diabetic activity of Egyptian celery APIGENIN
1518. Total synthesis of scutellarin and APIGENIN 7-O-β-d-glucuronide
1519. Efflux transport of chrysin and APIGENIN sulfates in HEK293 cells overexpressing SULT1A3: The role of multidrug resistance-associated protein 4 (MRP4/ABCC4)
1520. Effects of APIGENIN and APIGENIN-loaded nanogel on induction of apoptosis in human chronic myeloid leukemia cells
1521. Synthesis, characterization and free radical scavenging activity of APIGENIN with or without magnesium (II)
1522. Adsorption and inhibitive properties of APIGENIN derivatives as eco-Friendly corrosion inhibitors for brass in nitric acid solution
1523. Effects of APIGENIN on the expression levels of B‑cell lymphoma‑2, Fas and Fas ligand in renal ischemia‑reperfusion injury in rats
1524. Protective Role of APIGENIN Against Aβ 25–35 Toxicity Via Inhibition of Mitochondrial Cytochrome c Release
1525. Effect of luteolin and APIGENIN on the expression of Oct-4, Sox2, and c-Myc in dental pulp cells with in vitro culture
1526. Efficacy of Concanavalin-A conjugated nanotransfersomal gel of APIGENIN for enhanced targeted delivery of UV induced skin malignant melanoma
1527. Simultaneous quantification of glycyrrhetinic acid and APIGENIN using HPTLC from Glycyrrhiza glabra Linn
1528. Plant flavone APIGENIN protects against cyclosporine-induced histological and biochemical changes in the kidney in rats
1529. Preparation, in-vitro release and antioxidant potential of formulation of APIGENIN with hydroxypropyl-β-cyclodextrin modified microemulsion
1530. APIGENIN reduces NF-κB and subsequent cytokine production as protective effect in a rodent animal model of lung ischemia-reperfusion injury
1531. Simultaneously improving the physicochemical properties, dissolution performance, and bioavailability of APIGENIN and daidzein by co-crystallization with theophylline
1532. APIGENIN relaxes rat intrarenal arteries, depresses Ca2+-activated Cl− currents and augments voltage-dependent K+ currents of the arterial smooth muscle …
1533. Synergistic protective effect of chlorogenic acid, APIGENIN and caffeic acid against carbon tetrachloride-induced hepatotoxicity in male mice
1534. APIGENIN decreases acinar cell damage in pancreatitis
1535. Simultaneous ultra performance liquid chromatography determination and antioxidant activity of linarin, luteolin, chlorogenic acid and APIGENIN in different parts of …
1536. Anti-oxidative and anti-apoptotic effects of APIGENIN on number of viable and apoptotic blastomeres, zona pellucida thickness and hatching rate of mouse …
1537. Tuning phospholipid bilayer permeability by flavonoid APIGENIN: Electrochemical and atomic force microscopy study
1538. Comparative pharmacokinetic profiles of selected irreversible tyrosine kinase inhibitors, neratinib and pelitinib, with APIGENIN in rat plasma by UPLC–MS/MS
1539. Identification and analysis of APIGENIN metabolites in rats
1540. Dietary APIGENIN potentiates the inhibitory effect of interferon-α on cancer cell viability through inhibition of 26S proteasome-mediated interferon receptor degradation
1541. Determination of total APIGENIN in herbs by micellar electrokinetic chromatography with UV detection
1542. Quantification of APIGENIN trimethyl ether in rat plasma by liquid chromatography–tandem mass spectrometry: application to a pre-clinical pharmacokinetic study
1543. Commitment of human pluripotent stem cells to a neural lineage is induced by the pro-estrogenic flavonoid APIGENIN
1544. APIGENIN inhibits C5a-induced proliferation of human nasopharyngeal carcinoma cells through down-regulation of C5aR
1545. APIGENIN-mediated Alterations in Viability and Senescence of SW480 Colorectal Cancer Cells Persist in The Presence of L-thyroxine
1546. APIGENIN-7-O-glucoside oxidation catalyzed by P450-bioinspired systems
1547. The effects of APIGENIN and curcumin on autophagy related cell death and apoptosis
1548. APIGENIN and Quercetin: Potential Therapeutic Challenging Effective Against in Alzheimer’s Disease
1549. Construction, in vitro release and rheological behavior of APIGENIN-encapsulated hexagonal liquid crystal
1550. Comparative bio-accessibility, bioavailability and bioequivalence of quercetin, APIGENIN, glucoraphanin and carotenoids from freeze-dried vegetables …
1551. APIGENIN inhibits human SW620 cell growth by targeting polyamine catabolism
1552. APIGENIN isolated from A. americana encodes human and Aspergillus oryzae S2 α-amylase inhibitions: credible approach for antifungal and antidiabetic therapies
1553. APIGENIN, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1)
1554. Protective effect of APIGENIN on bleomycin-induced pulmonary fibrosis in mice by increments of lung antioxidant ability and PPARγ expression
1555. APIGENIN-7-O-β-D-glucuronide inhibits modified low-density lipoprotein uptake and foam cell formation in macrophages
1556. Involvement of Bcl-2 signal pathway in the protective effects of APIGENIN on anoxia/reoxygenation-induced myocardium injury
1557. Dietary APIGENIN in the prevention of endothelial cell dysfunction
1558. Four in vitro activities of APIGENIN to human colorectal carcinoma cells susceptible to air-oxidative and heating treatments
1559. APIGENIN and wogonin regulate epidermal growth factor receptor signaling pathway involved in MUC5AC mucin gene expression and production from …
1560. Study on extraction and purification of APIGENIN and the physical and chemical properties of its complex with lecithin
1561. RNA-seq analysis of the Rhizobium tropici CIAT 899 transcriptome shows similarities in the activation patterns of symbiotic genes in the presence of APIGENIN …
1562. Novel triazole analogs of APIGENIN‑7‑methyl ether exhibit potent antitumor activity against ovarian carcinoma cells via the induction of mitochondrial‑mediated …
1563. QM/MM–PB/SA scoring of the interaction strength between Akt kinase and APIGENIN analogues
1564. APIGENIN-7-O-β-D-glycoside isolation from the highly copper-tolerant plant Elsholtzia splendens
1565. Phytochemical investigation of Sonchus oleraceus (Family: Asteraceae) cultivated in Iraq, isolation and identification of quercetin and APIGENIN
1566. APIGENIN reduces proteasome inhibition-induced neuronal apoptosis by suppressing the cell death process
1567. UHPLC assisted simultaneous separation of APIGENIN and prednisolone and its application in the pharmacokinetics of APIGENIN
1568. Inhibitory effect of APIGENIN on losartan metabolism and CYP2C9 activity in vitro
1569. Prediction of C-glycosylated APIGENIN (vitexin) biosynthesis in Ficus deltoidea based on plant proteins identified by LC-MS/MS
1570. Anti-inflammatory and anti-apoptotic potentials of APIGENIN against liver injury induced by ischemia-reperfusion in rats
1571. APIGENIN from daily vegetable celery can accelerate bone defects healing
1572. Antibacterial activity of APIGENIN, luteolin, and their C-glucosides
1573. APIGENIN inhibits indoxyl sulfate-induced endoplasmic reticulum stress and anti-proliferative pathways, CHOP and IL-6/p21, in human renal proximal tubular …
1574. Bioactivity guided isolation of APIGENIN from Stachys lavandulifolia Vahl. in mice with anxiolytic effects
1575. Preparation and characterization of novel pseudo ceramide-based nanostructured lipid carriers for transdermal delivery of APIGENIN
1576. Relaxation of isolated guinea-pig trachea by APIGENIN, a constituent of celery, via inhibition of phosphodiesterase
1577. Development and validation of a novel high-performance thin-layer chromatography method for the simultaneous determination of APIGENIN and luteolin in Hygrophila …
1578. Simultaneous separation of APIGENIN, luteolin and rosmarinic acid from the aerial parts of the copper-tolerant plant Elsholtzia splendens
1579. Extraction of luteolin and APIGENIN from leaves of perilla frutescens (L.) Britt. with liquid carbon dioxide
1580. α-Mangostin and APIGENIN induced the necrotic death of BT474 breast cancer cells with autophagy and inflammation
1581. Retracted-miR-423-5p knockdown enhances the sensitivity of glioma stem cells to APIGENIN through the mitochondrial pathway
1582. Healing of Growth Plate Cartilage by Hypoxia Inducible Factor-1a Inhibitor APIGENIN on Thiram Induced Tibial Dyschondroplasia.
1583. BH3 mimetic ABT-263 enhances the anticancer effects of APIGENIN in tumor cells with activating EGFR mutation
1584. Bronchodilator effect of APIGENIN and luteolin, two components of Dracocephalum kotschyi on isolated rabbit trachea
1585. Validated HPTLC method for quantification of luteolin and APIGENIN in Premna mucronata Roxb., Verbenaceae
1586. Features of APIGENIN, luteolin, hesperetin and naringenin in crop and body
1587. Quercetin and APIGENIN of Cymbopogon citratus mediate inhibition of HCT-116 and PC-3 cell cycle progression and ameliorate Doxorubicin-induced testicular …
1588. Non-clinical studies for evaluation of 8-C-rhamnosyl APIGENIN purified from Peperomia obtusifolia against acute edema
1589. Alteration in biochemical parameters in the brain of transgenic Drosophila melanogaster model of Parkinson’s disease exposed to APIGENIN
1590. Determining the contents of rupestonic acid, vitexicarpin, APIGENIN, and luteolin in Artemisia rupestris L. in different growth stages by thin-layer chromatographic …
1591. APIGENIN ameliorates vascular injury in rats with high fructose-induced metabolic disturbance by inhibiting PI3K/AKT/GLUT1
1592. APIGENIN modulates the expression levels of pro-inflammatory mediators to reduce the human insulin amyloid-induced oxidant damages in SK-N-MC cells
1593. Competitive inhibition of quercetin and APIGENIN at the ATP binding site of D-alanine-D-alanine ligase of Helicobacter pylori–A molecular modeling approach
1594. The non-additive contribution of hydroxyl substituents to Akt kinase–APIGENIN affinity
1595. The effects of experimental conditions of fluorescence quenching on the binding parameters of APIGENIN to bovine serum albumin by response surface methods
1596. APIGENIN protects myocardium by inhibiting the TGF-β1-mediated Smad signaling transduction pathway in acute myocardial infarcted rats
1597. APIGENIN exerts anticancer effects on human cervical cancer cells via induction of apoptosis and regulation of Raf/MEK/ERK signalling pathway
1598. Microbial metabolism of prenylated APIGENIN derivatives by Mucor hiemalis
1599. APIGENIN restores impairment of autophagy and downregulation of unfolded protein response regulatory proteins in keratinocytes exposed to ultraviolet B …
1600. Intestinal permeability and transport of APIGENIN across caco-2 cell monolayers
1601. Identification of the vibrational spectra of APIGENIN and luteolin
1602. The flavone APIGENIN blocks nuclear translocation of sterol regulatory element-binding protein-2 in the hepatic cells WRL-68
1603. Solubility and dissolution rate improvement of the inclusion complex of APIGENIN with 2-hydroxypropyl-β-cyclodextrin prepared using the liquid antisolvent precipitation …
1604. Traversal of the Blood–Brain Barrier by Cleavable l-Lysine Conjugates of APIGENIN
1605. Larvicidal activity and Biochemical effects of APIGENIN against filarial vector Culex quinquefasciatus
1606. APIGENIN increases maspin expression and suppresses invasiveness in prostate cancer cells
1607. APIGENIN improves myocardial function and attenuates cardiotoxicity induced by doxorubicin in male rats
1608. Identification of APIGENIN and luteolin in Artemisia annua L. for the quality control
1609. Induction of apoptosis by gamma-irradiated APIGENIN in H1975 human non-small lung cells
1610. Anti-inflammatory Activity of Bioactive Flavonoid APIGENIN-7-O-β-D-Glucuronide Methyl Ester from Ethyl Acetate Leaf Extract of Manilkara zapota on …
1611. GW27-e0367 APIGENIN attenuates the cardiac remodeling in experimental diabetic cardiomyopathy
1612. APIGENIN restores normal vascular reactivity in diabetic rats via protein kinase C inhibition
1613. 39 Studies on the antidiabetic activity of APIGENIN in mice with streptozotocin-induced diabetes
1614. Analysis of anthocyanin and APIGENIN contents and the expression profiles of biosynthesis-related genes in the purple and non-purple varieties of celery.
1615. The antagonism between APIGENIN and protoapigenone to the PDK-1 target in Macrothelypteris torresiana
1616. Simultaneous estimation of luteolin and APIGENIN in methanol leaf extract of Bacopa monnieri Linn by HPLC
1617. New acylated APIGENIN glycosides from edge flowers of Matricaria chamomilla
1618. In Vitro Anti Cancer Activity and detection of Quercetin, APIGENIN in Methanol extract of Euphorbia nivulia Buch.-Ham. By HPTLC Technique
1619. Total synthesis of 8-(6 ″-umbelliferyl)-APIGENIN and its analogs as anti-diabetic reagents
1620. Vasodilation Effect of Oleanolic Acid and APIGENIN as a Metabolite compound of Anredera cordifolia (Ten) V Steenis on isolated rabbit aortic and frog heart
1621. Effects of APIGENIN on lipopolysaccharide induced proliferation of rat aortic vascular smooth muscle cells
1622. APIGENIN inhibits rat neurosteroidogenic 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase
1623. Reversal of Warburg effect by APIGENIN and 5-Fluorouracil loaded dual drug liposomes result in enhanced colorectal chemotherapy
1624. Protective role of APIGENIN against rotenone induced model of parkinson’s disease: behavioral study
1625. Development and validation of a high-performance thin-layer chromatographic—densitometric method for the quantification of APIGENIN in Ocimum basilicum L. seed …
1626. Determination of captopril in rat plasma by LC-MS/MS in presence of APIGENIN
1627. Electrochemical determination of APIGENIN as an anti-gastric cancer drug in Lobelia chinensis using modified screen-printed electrode
1628. A18239 APIGENIN ameliorates streptozotocin induced diabetic nephropathy in rats by modulation of oxidative stress, apoptosis and inflammation through MAPK …
1629. Molecular mechanism of APIGENIN on inhibition of LPS-induced inflammatory mediators in murine macrophages
1630. Probing the influence of carboxyalkyl groups on the molecular flexibility and the charge density of APIGENIN derivatives
1631. Isolation of APIGENIN-7-O-(6”-OE-caffeoyl)-β-D-glucopyranoside from Leucas aspera L. with anti-inflammatory and wound healing activities
1632. Anti-Tumor Potential of APIGENIN and Luteolin in Cervical Cancer
1633. Extraction of APIGENIN and luteolin from leaves of alfalfa (Medicago sativa L.) using mixtures of liquid carbon dioxide and ethanol
1634. APIGENIN suppresses angiogenesis by inhibiting tube formation and inducing apoptosis
1635. Effects of APIGENIN on self-renewal and uPAR expression in NCI-H446 cell line
1636. The Effects of APIGENIN on Cell Proliferation and Apoptosis in Glioblastoma Multiforme
1637. Adsorption properties for separation of APIGENIN from Viola yedoensis on LSA-10 resin
1638. Isolation and molecular recognization of 6-prenyl APIGENIN towards MAO-A as the active principle of seeds of Achyranthes aspera
1639. A highly selective and sensitive fluorescence sensor for the detection of APIGENIN based on nitrogen doped carbon dots and its application in cell imaging
1640. Subchronic Exposure of APIGENIN Induces Hepatic Oxidative Stress in Male Rats
1641. Insight into the novel inhibition mechanism of APIGENIN to Pneumolysin by molecular modeling
1642. Scale-up of one-step synthesis of acacetin and APIGENIN using 915 MHz microwaves
1643. Contribution of APIGENIN di-C-glycosides and lutein to the colour of yellow alkaline noodles
1644. Supercritical carbon dioxide extraction of APIGENIN from parsley leaves pre-treated to maximize yield
1645. Bioaccessibility of APIGENIN from Mangifera indica (Water Lily Var.) during in vitro gastrointestinal digestion.
1646. Antiproliferative effect of APIGENIN: A flavonoid in sarcoma 180 cell line
1647. Effect of APIGENIN on acrylontrile-induced lipid peroxidation and DNA damage in sperm of male rats
1648. Ex vivo and in silico Molecular Docking Studies of Aldose Reductase Inhibitory Activity of APIGENIN from Morus indica L.
1649. The polyphenolic compound APIGENIN and applications to cervical cancer
1650. Effects of APIGENIN on marked enzymes and oxidation-reduction balance in testicular of male rats
1651. Hypolipidemic Effect of APIGENIN Extracted From Parsley (Petroselinum sativum L.) Leaves In Cadmium Chloride Treated Rats (Part II)
1652. Identification of APIGENIN-7-Glucoside and Luteolin-7-Glucoside in Pleurotus porrigens and Schizophyllum commune Mushrooms by Liquid Chromatography–Ion Trap …
1653. Is Mitochondria Biogenesis and Neuronal Loss Prevention in Rat Hippocampus Promoted by APIGENIN?
1654. Evaluation of the in vitro and in vivo inhibitory effects of APIGENIN and gallic acid on the growth of Babesia and Theileria parasites
1655. Validation and Development of HPTLC Method for Simultaneous Estimation of APIGENIN and Luteolin in Selected Marketed Ayurvedic Formulations of ‘ …
1656. Synthesis of APIGENIN-samarium Complex and Its Anti-hyperuricemia in Mice
1657. APIGENIN increases cisplatin inhibitory effects on the telomerase activity of triple negative breast cancer cells
1658. Molecular Docking and Toxicity Test of APIGENIN Derivative Compounds as an Anti-Aging Agent
1659. APIGENIN-7-O-?-D-Glucuronide Methyl Ester Isolated from Manilkara zapota Leaves
1660. Optimization of ultrasound-assisted extraction of quercetin, luteolin, APIGENIN, pinocembrin and chrysin from Flos populi by Plackett-Burman design combined …
1661. Antiangiogenic potential of yogurts added with extracts rich in APIGENIN derivatives
1662. APIGENIN suppresses inhibitor of apoptosis family protein expression and disrupts Ku70-bax interaction in prostate cancer cells in culture and in vivo
1663. Evaluation of in-vitro and in-vivo anti-inflammatory activities of APIGENIN and vitexin
1664. APIGENIN an Naringenin
1665. Purification of luteolin and APIGENIN from celery leaves using hybrid organic–inorganic monolithic cartridge
1666. Synthesis and DNA Cleavage Activity of Pyrazinedimethylformamide Bridged APIGENIN Copper (Ⅱ) Complex
1667. A new strategy for treating Staphylococcus aureus pneumonia: combination therapy of LysGH15 and APIGENIN
1668. Protective effect of APIGENIN in a rat model of lung ischemia-reperfusion
1669. Flavonoid APIGENIN Is an Inhibitor of the NAD+ ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome …
1670. Molecular docking studies on APIGENIN as a target with MAPK p38 for cardiovascular diseases
1671. APIGENIN nanoparticle suppresses sphere formation in CD133+/ALDH1high prostate cancer stem cells through downregulation of stem cell markers
1672. Nutraceutical APIGENIN: Mechanism of action associated with its anti-inflammatory activity and regulation of dendritic cell metabolism
1673. The effect of APIGENIN on lipopolysaccharide-induced acute lung injury and its mechanism in mice
1674. The role of Quercetin and APIGENIN for attenuating hypercholesterolemia
1675. Anti-cancer Effect of APIGENIN on Human Breast Carcinoma MDA-MB-231 through Cell Cycle Arrest and Apoptosis
1676. Retracted Article: Identifying the inhibitory mechanism of APIGENIN on the insulin ligand–receptor binding
1677. Apoptotic mechanism of APIGENIN and rutin in ER+-breast cancer cells, MCF-7
1678. Nutraceutical APIGENIN regulates DC function in a RelB-dependent manner during neuroinflammation
1679. Spectroscopic Properties of APIGENIN in Various Bulk Solutions and Aerosol‐OT Reverse Micelles
1680. Simultaneous Determination of APIGENIN and Quercetin in External Application Liquid of Potentilla kleiniana Wight et Arn by HPLC
1681. OPTIMIZATION OF APIGENIN LIGAND IN THE 99M TC-APIGENIN COMPOUND SYNTHESIS PROCESS AS A POTENTIAL RADICAL SCAVENGER AGENT
1682. APIGENIN Attenuates Pulmonary Hypertension by Inducing PASMCs Mitochondria-Dependent Apoptosis Via Inhibiting Hypoxia Inducible Factor 1α-KV1. 5 Channel …
1683. Development of Drug Delivery System for APIGENIN against Inflammatory Disease-Approach for Clinical Application of Natural Products
1684. Liquid chromatography-mass spectrometric method for simultaneous estimation of APIGENIN and luteolin from Achillea millefolium Linn.
1685. Determination of luteolin-7-O-β-D-glucopyranoside, luteolin-7-O-β-D-glucuronopyranoside, and APIGENIN-7-O-β-D-glucuronopyranoside in Ixeris sonchifolia by HPLC …
1686. APIGENIN inhibits proliferation and migratory properties of Barrett’s esophageal adenocarcinoma cells by targeting PI3K/Akt/mTOR pathway
1687. Structural basis and energy landscape of APIGENIN-induced cancer cell apoptosis mechanism in PI3K/Akt pathway
1688. Evaluation of Anti-oxidant and Anti-cancer Properties of Silver Nanoparticles Synthesized by APIGENIN toward Breast Cancer MCF-7 Cell Line
1689. Research progress on prevention and treatment of T2DM with APIGENIN
1690. Local orbital locator analysis of isomeric compounds of luteolin and APIGENIN
1691. Research Progress on Structure Modification and Activity of APIGENIN
1692. APIGENIN ameliorates ocular surface lesions in a rat model of dry eye disease
1693. Comparing the Effects of Kaempferol, Galangin and APIGENIN Flavanoids on Basis of its Structural Differences in Increasing of Paraoxonase 1 Activity and Attenuating …
1694. Neuroprotective effects of APIGENIN in Human Neuroblastoma SH-SY5Y cells Against Rotenone toxicity: a pilot study.
1695. Potential ABTS Reducing and Anti-collagenase Activity of Scutellarein and APIGENIN
1696. Co-administrating APIGENIN in a high-cholesterol diet prevents hypercholesterolaemia in golden hamsters
1697. Role of Bcl-2 signal pathway in APIGENIN preconditioning against cardiomyocytes anoxia/reoxygenation injury
1698. Simple and sensitive high performance liquid chromatographic (HPLC) method for the determination of the APIGENIN from dried powder of Cosmos bipinnatus, Apium …
1699. Prediction of potential drug interactions of APIGENIN based on molecular docking and in vitro inhibition experiments
1700. Anti-adipogenic activity of Carduus crispus and its constituent APIGENIN in 3T3-L1 adipocytes by downregulating PPARγ and C/EBPα
1701. … and Antioxidant Activity of the Cu (II) Metal Complex with 2-p-Hydroxy Benzoic-4-p-Tolyl Imino-5, 7-two Hydroxy Benzopyran as a Ligand Derived from APIGENIN
1702. Chemoprevention by APIGENIN
1703. Red betel APIGENIN compound (Piper crocatum Ruiz & Pav.) as an anti-inflammatory rheumatoid arthritis agent through virtual screening
1704. Study on kinectics characteristics of the sulfation of APIGENIN by SULTIA3
1705. A1935 Modulation of TRPV4 by APIGENIN ameliorates renal fibrosis in DOCA salt hypertensive rats
1706. The role of APIGENIN loaded Nano structured Lipid Carriers in increasing docetaxel efficiency in lung cancer chemotherapy
1707. Uptake Study on APIGENIN in Caco-2 Cells
1708. APIGENIN oxidovanadium (IV) cation interactions
1709. Influence of APIGENIN on the cariogenicity of Streptococcus mutans
1710. Study on the Electrochemical Behaviour of APIGENIN and its Interaction with DNA
1711. Evaluation of immunochemotherapy effects of APIGENIN in female balb/c mice with breast cancer
1712. Efficacy and safety of a new topical hair loss-lotion containing oleanolic acid, APIGENIN, biotinyl tripeptide-1, diaminopyrimidine oxide, adenosine, biotin and …
1713. APIGENIN and Baicalin, Each Alone or in Low Dose Combination, Attenuated Chloroquine Induced Male Infertility in Adult Rats
1714. Antioxidant and Inhibition of Elastase Effect of Scutellarein and APIGENIN
1715. Papatya içeren kozmetiklerde APIGENIN miktar tayini/Determination of APIGENIN in cosmetics formulations containing chamomile
1716. Analysis of efficacy of L-APIGENIN A in the treatment of Alzheimer’s disease
1717. Drug delivery approaches for APIGENIN: A review
1718. Interactions between Dietary Flavonoid APIGENIN and Human Gut Microbiota in vitro
1719. Effect of APIGENIN on 3T3-L1 Cells
1720. Effects of APIGENIN on Experimental Ischemia/Reperfusion Injury in the Rat Ovary.
1721. Toxcity Assessment of the Pesticide, Edifenphos and its Amelioration by APIGENIN.
1722. Corrigendum to “APIGENIN protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis”(APIGENIN protects HT22 murine …
1723. Preparation process of APIGENIN particles by supercritical CO_2 anti-solvent method
1724. THE EFFECT OF APIGENIN ON THE DEVELOPMENT OF MOUSE EMBRYOS IN VITRO
1725. CAPILLARY ELECTROPHORESIS OF APIGENIN
1726. Formulation of APIGENIN containing multiparticular drug delivery systems
1727. APIGENIN produced by maize flavone synthase I and II protects plants against UV-B-induced damage
1728. … OF THE OPTIMUM CONCENTRATION OF SNCL2. 2H2O AS A REDUCING AGENT IN THE LABELING OF APIGENIN COMPOUNDS WITH RADIONUCLIDE …
1729. Antiapoptotic effect of APIGENIN and vitamin E against deltamethrin induced toxicity in rats
1730. Resveratrol as a bioenhancer to improve anti-inflammatory activities of APIGENIN
1731. Nuclear overhauser effect in APIGENIN molecule
1732. APIGENIN Inducing Different Cells Apoptosis through Increasing ROS
1733. NUCLEAR OVERHAUSER EFFECT IN APIGENIN MOLECULE
1734. Development and characterization of APIGENIN transfersomal system for skin cancer
1735. Structure and Biological Activity of the La (Ⅲ) Complex with APIGENIN
1736. Potential targets prediction of APIGENIN via virtual screening
1737. APIGENIN relaxes rat intrarenal arteries: involvement of Cl− channels and K+ channels
1738. Effects of APIGENIN on in vivo pharmacokinetics of doxorubicin in rats
1739. Potential of the Flavonoid APIGENIN in Regulating Immune Cell Functions During Neuroinflammation in a RelB-dependent Manner
1740. Effect of APIGENIN on Inhibiting Proliferation and Apoptosis of Human NCI-H1650 Cell Line
1741. APIGENIN inhibits inflammation and T cell activation from murine lymphocytes
1742. Study on the stability of scavenging DPPH free radical by Viola philippica APIGENIN.
1743. The Flavonoid APIGENIN Inhibits Inducible Programmed Death Ligand 1 Expression by Breast Cancer Cells
1744. Isolation of APIGENIN from Antirrhinum majas
1745. The Immune-modulatory and Anti-carcinogenic Mechanisms of the Flavonoid APIGENIN
1746. Analysis of the erythroid differentiation effect of flavonoid APIGENIN
1747. Study on The PK-PD Model of APIGENIN-7-O-glucronide Based on The Cerebral Ischemia-Reperfusion Injury Model Rats
1748. Optimization of Extraction Process of APIGENIN in Celery Leaves and Its Antioxidant Activity in Vitro
1749. In Vivo Evaluation of “Meriva” Curcumin, and APIGENIN as Anti-inflammatory Drugs in a Mouse Model of Chronic Neuroinflammation
1750. Some of the APIGENIN Derivatives’ Impact on Polyphenol Oxidase Enzyme
1751. Study on the liver injury induced by APIGENIN in male mice
1752. APIGENIN and its Nano-Liposomal Formulation for Colorectal Cancer and Bacterial Chemotherapy
1753. APIGENIN ameliorates streptozotocin induced diabetic nephropathy in rats
1754. Interaction of APIGENIN and Hesperetin on Xanthine Oxidase Inhibition and Their Inhibitory Mechanism
1755. APIGENIN extraction from fresh Elsholtzia ciliata herb
1756. Effect of APIGENIN on the multidrug resistant breast cancer cell line MCF-7/ADR
1757. … of chronic neuroinflammation on cognition and behaviour in the GFAP-IL6 transgenic mouse and investigation of the flavonoid APIGENIN as a neuroprotective …
1758. FURTHER EVALUATION OF EUCALIPTOL, CARVACROL, APIGETRIN AND APIGENIN FOR THEIR IN VITRO ANTICANCER POTENTIAL
1759. The Protective Effects of APIGENIN on LPS-induced Acute Lung Injury in Mice
1760. Optimal extraction process of APIGENIN in Chromolaena odorata L by orthogonal experiment.
1761. Effect of APIGENIN on streptozotocin-induced diabetic liver injury in rats
1762. Pharmacokinetics of APIGENIN-7-O-glucronide in Normal and Middle Cerebral Artery Occlusion Rats
1763. Themes: Title: APIGENIN protects SK-N-MC cells against human insulin amyloid toxicity
1764. Effects of APIGENIN and luteolin on p53-dependent apoptosis and autophagy in colon cancer cells
1765. Synthesis and Recognition of APIGENIN Monodispersed Molecularly Imprinted Polymer
1766. Effects of APIGENIN on Platelet Derived Growth Factor-induced Migration of Vascular Smooth Muscle Cells
1767. Effects of APIGENIN on Renal Ischemia/reperfusion Injury Apoptosis in Rats by Fas/FasL
1768. Antiangiogenic Effects of the APIGENIN and/or Selenium on Ehrlish Bearing Mice
1769. Synthesis of Schiff Base Metal Derivatives of APIGENIN and Their Antioxidant Activity
1770. Retraction: Identifying the inhibitory mechanism of APIGENIN on the insulin ligand–receptor binding
1771. Plant-based product APIGENIN attenuates EAE severity through the modulation of immune cell function (THER7P. 948)
1772. Pleiotropic Molecular Effects of Dietary Polyphenols Resveratrol and APIGENIN in Leukemia
1773. Combination Therapy of LysGH15 and APIGENIN as a New Strategy for Treating Pneumonia Caused by Staphylococcus aureus
1774. APIGENIN (4’5, 7 Trihydroxyflavone) Inhibition of TNF-Alpha-Induced GRO Release in Triple Negative Breast MDA-MB-468 Cells
1775. Microbial metabolism of prenylated APIGENIN derivatives
1776. Formulation and Characterization of the Improved Solubility, In Vivo Bioavailability and Antioxidant Activity of APIGENIN-Phospholipid Complex (APLC)
1777. APIGENIN Inhibits LPS-induced Microglia Activation by Modulating MicroRNA Expression
1778. APIGENIN induces apoptosis through inhibit of MAPK signaling in A375SM and A375P melanoma cells
1779. Histopathological study in Lungs of mice implanted with mammary adenocarcinoma (AM3) and treated with flavonoids (APIGENIN)
1780. Histopathological study in Lungs of mice implanted with mammary adenocarcinoma (AM3) and treated with flavonoids (APIGENIN)
1781. Inhibitory effect of APIGENIN on proliferation and invasion of human malignant melanoma cells.
1782. APIGENIN reduces cell viability of Human epidermoid cancer cells (Hep-2)
1783. Activity of APIGENIN and quercetin on rat hepatic mitochondrial permeability transition pore.
1784. Effect of APIGENIN-induced autophagy on apoptosis in human gastric cancer cells SGC-7901
1785. HPLC determination of luteolin and APIGENIN in Herba Scutellariae barbatae
1786. APIGENIN and Naringenin Increase Apoptosis and Decrease Proliferation via Transcriptional Regulation
1787. The flavone APIGENIN blocks SREBP-2 activation in hepatic cells
1788. Spectroscopic Studies on the Interaction of Naringenin, APIGENIN with FTO
1789. Determination of luteolin and APIGENIN in Apium graveolen L. by HPLC.
1790. Determination of Naringenin and APIGENIN in Premna fulva Craib. by HPLC
1791. Determination of quercetin, luteolin and APIGENIN in Matricaria Chamomila L. by PR-HPLC
1792. Effects of APIGENIN on the Expressions of TGF-β1R II, NF-κB and VEGF Genes in Tumor Tissues of Mice with H29 Colon Cancer
1793. APIGENIN overcomes drug resistance by blocking signal transducer and activator of transcription 3 (STAT3) signaling in breast cancer
1794. Anti-cancer effects of APIGENIN by enhancing tumor necrosis factor-related apotosis-inducing ligand-mediated death receptor 5 expression and inhibition of telomerase …
1795. APIGENIN Modulation of Whole Transcriptome Patterns of TNFα‐Induced Changes in Triple Negative Breast Cancer Cells, MDA‐MB‐231
1796. Refining the methods of extraction and purification of APIGENIN from Viola yedoensis makino
1797. Effect of APIGENIN and cisplatin on telomerase activity and expression of its structural proteins in triple negative breast cancer/Noorfaiza A. Aziz
1798. Total synthesis of APIGENIN glycosides and the effect of these compounds on polyphenol oxidase enzyme activity
1799. Oral Efficacy of APIGENIN against Cutaneous Leishmaniasis: Involvement of Reactive Oxygen Species and Autophagy as a Mechanism of Action
1800. Effect of APIGENIN on Leishmania amazonensis Is Associated with Reactive Oxygen Species Production Followed by Mitochondrial Dysfunction
1801. Simultaneous Determination of Luteolin and APIGENIN in Mongolian Medicine Scabiosa atropurea by RP-HPLC
1802. Specific role of oxidized species in the bioactivity of two antioxidants: APIGENIN and 20-hydroxyecdysone
1803. APIGENIN has anti-atrophic gastritis and anti-gastric cancer progression effects in Helicobacter pylori-infected Mongolian gerbils
1804. Simultaneous Determination of Scutellarin, Protopine, APIGENIN and Tetrahydropalmatine in Dengyan Granules by HPLC
1805. The flavonoid APIGENIN upregulates CD26/DPPIV on human colorectal carcinoma cells
1806. Plant Flavone APIGENIN Binds to Nucleic Acid Bases and Reduces Oxidative DNA Damage in Prostate
1807. Inhibitory Effect of Self-made Jiawei Weijing Decoction and APIGENIN on Proliferation, Cell-cycle and Apoptosis of Lung Adenocarcinoma A549 Cell
1808. Microencapsulation of plant extracts rich in APIGENIN to be used as chemopreventive agents in functional foods
1809. APIGENIN inhibit UV-induced melanogenesis through activation of MIF and PAR-2 expression in keratinocytes
1810. Determination of verbascoside, luteolin and APIGENIN in siphonostegia chinensis by HPLC.
1811. Synergistic effects of cisplatin and APIGENIN on telomerase expression and telomerase activity in TNBC cells/Associate Professor Dr Gabriele Ruth Anisah Froemming …
1812. PS 13-22 APIGENIN ATTENUATES ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN DIABETIC RATS VIA MODULATION OF PPAR-γ PATHWAY: A PRE …
1813. Fabrication of Tamarind Gum Based Nanoemulsion Gel of APIGENIN for UV Induced Skin Carcinoma
1814. Study and ch aracterization of the antioxidant activity of the inclusion complex of APIGENIN with?-cyclodextrin and 2-hydroxylpropyl?-cyclodextrin in solution
1815. APIGENIN attenuates CCL2 release from TNFα and IL‐1a stimulated MDA‐MB‐231 triple negative breast cancer cells
1816. Antimicrobial evaluation and quantification of APIGENIN content by HPTLC in methanol stem extract of Cardiospermum halicacabum L
1817. High-yield production of APIGENIN from celery with ultrasonic-assisted β-glucosidase hydrolysis.
1818. Determination of scutellarin, baicalein, luteolin and APIGENIN in Herba Scutellariae barbatae by HPLC
1819. Inhibition of APIGENIN on lipopolysaccharide-induced bone-marrow-derived macrophages inflammation through NF-κB and MAPK.
1820. Simultaneous Determination of Chlorogenic Acid, Luteolin, APIGENIN and Acacetin in Medicinal Chrysanthemum morifolium by HPLC
1821. Hypolipidemic Effect of APIGENIN Extracted From Parsley (Petroselinum sativum L.) Leaves In Cadmium Chloride Treated Rats (Part II)
1822. Effect on oxidative stress, glucose uptake level and lipid droplet content by APIGENIN 7, 4′-dimethyl ether isolated from Piper longum L
1823. APIGENIN induces apoptosis by suppressing Bcl-xL and Mcl-1 simultaneously through signal transducer and activator of transcription 3 (STAT3) signaling in colon …
1824. Induction of NRF2-mediated gene expression by dietary phytochemical flavones APIGENIN and luteolin
1825. Comparison of the molecular interactions of 7′-carboxyalkyl APIGENIN derivatives with S. cerevisiae α-glucosidase
1826. APIGENIN 7-O-β-D-(6 ″-p-coumaroyl)-glucoside protects against myocardial ischemia/reperfusion injury through inhibition of NF-κB activation
1827. Haematological and histopathological effects of APIGENIN, phloretin and myricetin based on uterotrophic assay in immature Wistar female albino rats
1828. … -drying: effect of different encapsulating agents for spray-dried microcapsulesquality and encapsulation efficiency of rosmarinic acid, chlorogenic acid, and APIGENIN
1829. Simultaneous determination of isoquercetin, morin, quercetin, luteolin and APIGENIN in Limonium sinense (Girard) Kuntze by RP-HPLC
1830. Inhibiting glucose transporter-1 and the PI3K/Akt pathway with APIGENIN, siRNA, LY294002 or wortmannin affects the radiosensitivity of laryngeal squamous cell …
1831. 514 Efficacy of APIGENIN on UV-induced melanogenesis through activation of MIF and PAR-2 expression in keratinocytes
1832. miR-138 overexpression most effectively enhanced efficacy of APIGENIN to impair cell cycle progression and induce apoptosis in human malignant neuroblastoma SK …
1833. APIGENIN as an anticancer agent
1834. Rationalizing the therapeutic potential of APIGENIN against cancer
1835. Antiviral activity of APIGENIN against buffalopox: Novel mechanistic insights and drug-resistance considerations
1836. Recent insights into the biological functions of APIGENIN
1837. The anticancer potential of APIGENIN via immunoregulation
1838. APIGENIN induced autophagy and stimulated autophagic lipid degradation
1839. Comparative study on the biological effects of sodium citrate-based and APIGENIN-based synthesized silver nanoparticles
1840. An APIGENIN-based bio-benzoxazine with three polymerizable functionalities: sustainable synthesis, thermal latent polymerization, and excellent thermal properties of …
1841. APIGENIN-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer’s disease
1842. Multi-spectroscopic, conformational, and computational atomic-level insights into the interaction of β-lactoglobulin with APIGENIN at different pH levels
1843. APIGENIN as tumor suppressor in cancers: biotherapeutic activity, nanodelivery, and mechanisms with emphasis on pancreatic cancer
1844. Hepatoprotective Effect of APIGENIN Against Liver Injury via the Non-canonical NF-κB Pathway In Vivo and In Vitro
1845. Neuroimmunomodulatory and neuroprotective effects of the flavonoid APIGENIN in in vitro models of neuroinflammation associated with Alzheimer’s disease
1846. The genome sequence of celery (Apium graveolens L.), an important leaf vegetable crop rich in APIGENIN in the Apiaceae family
1847. APIGENIN inhibits STAT3/CD36 signaling axis and reduces visceral obesity
1848. APIGENIN role as cell-signaling pathways modulator: implications in cancer prevention and treatment
1849. Cytotoxicity of APIGENIN toward multiple myeloma cell lines and suppression of iNOS and COX-2 expression in STAT1-transfected HEK293 cells
1850. Therapeutic potentials of the natural plant flavonoid APIGENIN in polycystic ovary syndrome in rat model: via modulation of pro-inflammatory cytokines and antioxidant …
1851. APIGENIN suppresses influenza A virus‐induced RIG‐I activation and viral replication
1852. APIGENIN 7-O-glucoside promotes cell apoptosis through the PTEN/PI3K/AKT pathway and inhibits cell migration in cervical cancer Hela cells
1853. Investigation of the anti-inflammatory and antioxidant activities of luteolin, kaempferol, APIGENIN and quercetin
1854. Investigation of possible effects of APIGENIN, sorafenib and combined applications on apoptosis and cell cycle in hepatocellular cancer cells
1855. Establishment and assessment of cell suspension cultures of Matricaria chamomilla as a possible source of APIGENIN under static magnetic field
1856. APIGENIN protects human melanocytes against oxidative damage by activation of the Nrf2 pathway
1857. APIGENIN inhibits histamine-induced cervical cancer tumor growth by regulating estrogen receptor expression
1858. APIGENIN induces apoptosis by regulating Akt and MAPK pathways in human melanoma cell A375SM
1859. APIGENIN prevents acetaminophen-induced liver injury by activating the SIRT1 pathway
1860. APIGENIN, a flavonoid constituent derived from P. villosa, inhibits hepatocellular carcinoma cell growth by CyclinD1/CDK4 regulation via p38 MAPK-p21 signaling
1861. Enhancing oral bioavailability of APIGENIN using a bioactive self-nanoemulsifying drug delivery system (Bio-SNEDDS): in vitro, in vivo and stability evaluations
1862. APIGENIN ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation
1863. APIGENIN attenuates the allergic reactions by competitively binding to ER with estradiol
1864. Effect of luteolin and APIGENIN on the production of IL-31 and IL-33 in lipopolysaccharides-activated microglia cells and their mechanism of action
1865. Neuroprotective effect of APIGENIN against cerebral ischemia/reperfusion injury
1866. Epileptic brain fluorescent imaging reveals APIGENIN can relieve the myeloperoxidase-mediated oxidative stress and inhibit ferroptosis
1867. Prevention by dietary polyphenols (resveratrol, quercetin, APIGENIN) against 7-ketocholesterol-induced oxiapoptophagy in neuronal N2a cells: potential interest for the …
1868. APIGENIN promotes antibacterial activity via regulation of nitric oxide and superoxide anion production
1869. A comparison of the effects of APIGENIN and seven of its derivatives on selected biomarkers of oxidative stress and coagulation in vitro
1870. APIGENIN attenuates pulmonary hypertension by inducing mitochondria-dependent apoptosis of PASMCs via inhibiting the hypoxia inducible factor 1α–KV1. 5 channel …
1871. Delivery of APIGENIN-loaded magnetic Fe2O3/Fe3O4@ mSiO2 nanocomposites to A549 cells and their antitumor mechanism
1872. APIGENIN attenuates TGF-β1-stimulated cardiac fibroblast differentiation and extracellular matrix production by targeting miR-155-5p/c-Ski/Smad pathway
1873. APIGENIN and Abivertinib, a novel BTK inhibitor synergize to inhibit diffuse large B-cell lymphoma in vivo and vitro
1874. APIGENIN Increases SHIP-1 Expression, Promotes Tumoricidal Macrophages and Anti-Tumor Immune Responses in Murine Pancreatic Cancer
1875. APIGENIN alleviates renal fibroblast activation through AMPK and ERK signaling pathways in vitro
1876. APIGENIN-Loaded PLGA-DMSA Nanoparticles: A Novel Strategy to Treat Melanoma Lung Metastasis
1877. Efficiency comparison of APIGENIN-7-O-glucoside and trolox in antioxidative stress and anti-inflammatory properties
1878. APIGENIN protects mouse retina against oxidative damage by regulating the Nrf2 pathway and autophagy
1879. APIGENIN and Structurally Related Flavonoids Allosterically Potentiate the Function of Human α7-Nicotinic Acetylcholine Receptors Expressed in SH-EP1 Cells
1880. APIGENIN exhibits anti-inflammatory effects in Lps-stimulated Bv2 microglia through activating Gsk3β/Nrf2 signaling pathway
1881. APIGENIN reverses behavioural impairments and cognitive decline in kindled mice via CREB-BDNF upregulation in the hippocampus
1882. APIGENIN Modulates Dendritic Cell Activities and Curbs Inflammation Via RelB Inhibition in the Context of Neuroinflammatory Diseases
1883. Metformin-induced ROS upregulation as amplified by APIGENIN causes profound anticancer activity while sparing normal cells
1884. Luteolin and APIGENIN attenuate LPS-induced astrocyte activation and cytokine production by targeting MAPK, STAT3, and NF-κB signaling pathways
1885. A natural flavonoid, APIGENIN isolated from Clerodendrum viscosum leaves, induces G2/M phase cell cycle arrest and apoptosis in MCF-7 cells through the regulation …
1886. Does Oral APIGENIN Have Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?
1887. Co-folding of hydrophobic rice proteins and shellac in hydrophilic binary microstructures for cellular uptake of APIGENIN
1888. APIGENIN alleviated acetaminophen‐induced hepatotoxicity in low protein‐fed rats: Targeting oxidative stress, STAT3, and apoptosis signals
1889. APIGENIN attenuates Aluminum phosphide-induced cytotoxicity via reducing mitochondrial/Lysosomal damages and oxidative stress in rat Cardiomyocytes
1890. The natural flavones, acacetin and APIGENIN, induce Cdk-Cyclin mediated G2/M phase arrest and trigger ROS-mediated apoptosis in glioblastoma cells
1891. APIGENIN upregulation of CD26/DPPIV on colon epithelial cells requires inhibition of casein kinase 2
1892. Transcriptomics and proteomics analysis of system-level mechanisms in the liver of APIGENIN-treated fibrotic rats
1893. Effects of APIGENIN on RBL-2H3, RAW264. 7, and HaCaT Cells: Anti-Allergic, Anti-Inflammatory, and Skin-Protective Activities
1894. Melatonin and calcium modulate the production of rosmarinic acid, luteolin, and APIGENIN in Dracocephalum kotschyi under salinity stress
1895. The effect of kaempferol and APIGENIN on allogenic synovial membrane-derived stem cells therapy in knee osteoarthritic male rats
1896. APIGENIN enhanced antitumor effect of cisplatin in lung cancer via inhibition of cancer stem cells
1897. Protective effects of APIGENIN, APIGENIN-8-sulfonate, and APIGENIN-3′, 8-disulfonate on d-galactosamine-induced acute liver damage in mice
1898. Protective effect of APIGENIN magnesium complex on H2O2-induced oxidative stress and inflammatory responses in rat hepatic stellate cells
1899. Novel quercetin and APIGENIN-acetamide derivatives: design, synthesis, characterization, biological evaluation and molecular docking studies
1900. APIGENIN-loaded solid lipid nanoparticle attenuates diabetic nephropathy induced by streptozotocin nicotinamide through Nrf2/HO-1/NF-kB signalling pathway
1901. Transcriptome analysis of two structurally related flavonoids; APIGENIN and Chrysin revealed hypocholesterolemic and ketogenic effects in mouse embryonic …
1902. H19-Wnt/β-catenin regulatory axis mediates the suppressive effects of APIGENIN on tumor growth in hepatocellular carcinoma
1903. APIGENIN ameliorates oxidative stress and mitochondrial damage induced by multiwall carbon nanotubes in rat kidney mitochondria
1904. Midkine silencing enhances the anti–prostate cancer stem cell activity of the flavone APIGENIN: cooperation on signaling pathways regulated by ERK, p38, PTEN …
1905. Investigation of C-glycosylated APIGENIN and luteolin derivatives’ effects on protein tyrosine phosphatase 1B inhibition with molecular and cellular approaches
1906. Antioxidant APIGENIN relieves age-related muscle atrophy by inhibiting oxidative stress and hyperactive mitophagy and apoptosis in skeletal muscle of mice
1907. Protective effects of APIGENIN on altered lipid peroxidation, inflammation, and antioxidant factors in methotrexate-induced hepatotoxicity
1908. APIGENIN promotes osteogenic differentiation of mesenchymal stem cells and accelerates bone fracture healing via activating Wnt/β-catenin signaling
1909. Bioactive flavonoid APIGENIN and its nanoformulations: a promising hope for diabetes and cancer
1910. APIGENIN modulates hippocampal CREB-BDNF signaling in high fat, high fructose diet-fed rats
1911. Comparative study on the extraction of APIGENIN from parsley leaves (Petroselinum crispum L.) by ultrasonic and microwave methods
1912. CD38 inhibition by APIGENIN ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD+/NADH ratio and Sirt3 activity in renal …
1913. APIGENIN regulates activation of microglia and counteracts retinal degeneration
1914. APIGENIN protects mice against 3, 5-diethoxycarbonyl-1, 4-dihydrocollidine-induced cholestasis
1915. APIGENIN as a candidate prenatal treatment for trisomy 21: effects in human amniocytes and the Ts1Cje mouse model
1916. APIGENIN and Temozolomide Synergistically Inhibit Glioma Growth Through the PI3K/AKT Pathway
1917. APIGENIN Prevent Abdominal Aortic Aneurysms Formation by Inhibiting the NF-κB Signaling Pathway
1918. Impact of coadministration of APIGENIN and bone marrow stromal cells on damaged ovaries due to chemotherapy in rat: An experimental study
1919. APIGENIN-7-O-β-D-(-6”-p-coumaroyl)-glucopyranoside treatment elicits a neuroprotective effect through GSK-3β phosphorylation-mediated Nrf2 activation
1920. UHPLC-UV/PDA method validation for simultaneous quantification of luteolin and APIGENIN derivatives from Elaeis guineensis leaf extracts: An application for …
1921. Overcoming the hypoxia-induced drug resistance in liver tumor by the concurrent use of APIGENIN and paclitaxel
1922. APIGENIN by targeting hnRNPA2 sensitizes triple-negative breast cancer spheroids to doxorubicin-induced apoptosis and regulates expression of ABCC4 and ABCG2 …
1923. Salinity stress alters ion homeostasis, antioxidant activities and the production of rosmarinic acid, luteolin and APIGENIN in Dracocephalum kotschyi Boiss
1924. APIGENIN suppresses TGF-β1-induced cardiac fibroblast differentiation and collagen synthesis through the downregulation of HIF-1α expression by miR-122-5p
1925. Effects of APIGENIN treatment on random skin flap survival in rats
1926. APIGENIN, flavonoid component isolated from Gentiana veitchiorum flower suppresses the oxidative stress through LDLR-LCAT signaling pathway
1927. APIGENIN attenuates allergic responses of ovalbumin-induced allergic rhinitis through modulation of Th1/Th2 responses in experimental mice
1928. Targeting renal OATs to develop renal protective agent from traditional Chinese medicines: Protective effect of APIGENIN against Imipenem‐induced nephrotoxicity
1929. Mechanistic insights into the inhibition of pancreatic lipase by APIGENIN: Inhibitory interaction, conformational change and molecular docking studies
1930. APIGENIN restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging
1931. The neuroprotective effect of APIGENIN against OGD/R injury in rat hippocampal neurons.
1932. Luteolin and its derivative APIGENIN suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer
1933. Development and Characterization of Calcium-Alginate Beads of APIGENIN: In Vitro Antitumor, Antibacterial, and Antioxidant Activities
1934. The kinetic and thermodynamic studies of solid-liquid extraction of APIGENIN-glycosides from parsley (Petroselinum crispum)
1935. Effect of APIGENIN on whole transcriptome profile of TNFα‑activated MDA‑MB‑468 triple negative breast cancer cells
1936. Synergistic Effect of APIGENIN and Curcumin on Apoptosis, Paraptosis and Autophagy-related Cell Death in HeLa Cells
1937. Kolaviron (Kolaflavanone), APIGENIN, fisetin as potential Coronavirus inhibitors: In silico investigation
1938. Bioactive APIGENIN loaded oral nano bilosomes: Formulation optimization to preclinical assessment
1939. Discovery of Novel APIGENIN–Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer
1940. Production of isoorientin and isovitexin from luteolin and APIGENIN using coupled catalysis of glycosyltransferase and sucrose synthase
1941. APIGENIN induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells
1942. Critical roles of Rad54 in tolerance to APIGENIN‑induced Top1‑mediated DNA damage
1943. APIGENIN ameliorates D-galactose-induced lifespan shortening effects via antioxidative activity and inhibition of mitochondrial-dependent apoptosis in …
1944. Inhibitory Effects of APIGENIN on Tumor Carcinogenesis by Altering the Gut Microbiota
1945. APIGENIN enhances viability of random skin flaps by activating autophagy
1946. APIGENIN-7-O-β-d-(6″-p-coumaroyl)-glucopyranoside reduces myocardial ischaemia/reperfusion injury in an experimental model via regulating the inflammation …
1947. Efficient Production of Orientin and Vitexin from Luteolin and APIGENIN Using Coupled Catalysis of Glycosyltransferase and Sucrose Synthase
1948. Mechanism of Interactions of dsDNA Binding with APIGENIN and Its Sulfamate Derivatives Using Multispectroscopic, Voltammetric, and Molecular Docking Studies
1949. A novel APIGENIN derivative suppresses renal cell carcinoma via directly inhibiting wild-type and mutant MET
1950. Modulation of Th17 proliferation and IL-17A gene expression by acetylated form of APIGENIN in patients with multiple sclerosis
1951. Loading of APIGENIN extracted from parsley leaves on colloidal core-shell nanocomposite for bioavailability enhancement
1952. Bioengineering of Genetically Encoded Gene Promoter Repressed by the Flavonoid APIGENIN for Constructing Intracellular Sensor for Molecular Events
1953. APIGENIN Attenuates Acetaminophen-Induced Hepatotoxicity by Activating AMP-Activated Protein Kinase/Carnitine Palmitoyltransferase I Pathway
1954. APIGENIN and Luteolin Regulate Autophagy by Targeting NRH-Quinone Oxidoreductase 2 in Liver Cells
1955. Protective effect of APIGENIN on d-galactosamine/LPS-induced hepatocellular injury by increment of Nrf-2 nucleus translocation
1956. Ethanol-assisted kneading of APIGENIN with arginine for enhanced dissolution rate of APIGENIN: development of rapidly disintegrating tablets
1957. Improvement of Antioxidative Activity of APIGENIN by B12N12 Nanocluster: Antioxidative Mechanism Analysis
1958. APIGENIN and Ampicillin as Combined Strategy to Treat Severe Streptococcus suis Infection
1959. Incorporation of APIGENIN and tt-Farnesol into dental composites to modulate the Streptococcus mutans virulence
1960. Optimization of Pre-Inoculum, Fermentation Process Parameters and Precursor Supplementation Conditions to Enhance APIGENIN Production by a Recombinant …
1961. APIGENIN and ethaverine hydrochloride enhance retinal vascular barrier in vitro and in vivo
1962. Effect of APIGENIN on surface-associated characteristics and adherence of Streptococcus mutans
1963. APIGENIN and Hesperidin Downregulate DNA Repair Genes in MCF-7 Breast Cancer Cells and Augment Doxorubicin Toxicity
1964. Data-Independent Acquisition-Based Quantitative Proteomic Analysis Reveals the Protective Effect of APIGENIN on Palmitate-Induced Lipotoxicity in Human Aortic …
1965. APIGENIN effect against Leishmania tropica amastigotes in vitro
1966. Protective effect of APIGENIN on ethylene glycol-induced urolithiasis via attenuating oxidative stress and inflammatory parameters in adult male Wistar rats
1967. APIGENIN attenuated ethylene glycol induced urolithiasis in uninephrectomized hypertensive rats: A possible role of bikunin, BMP-2/4, and osteopontin
1968. Protective effects of APIGENIN against edifenphos-induced genotoxicity and cytotoxicity in rat hepatocytes
1969. APIGENIN Ameliorates Scopolamine-Induced Cognitive Dysfunction and Neuronal Damage in Mice
1970. IV curves of an APIGENIN dye and their analysis by a new parabolic function
1971. APIGENIN-loaded galactose tailored PLGA nanoparticles: A possible strategy for liver targeting to treat hepatocellular carcinoma
1972. Comparative biotransformation of luteolin and APIGENIN from the flower extract and the stem‐and‐leaf extract of Dendranthema morifolium Ramat. Tzvel. in rats
1973. Neuroprotective effect of APIGENIN against hypoxic-ischemic brain injury in neonatal rats via activation of the PI3K/Akt/Nrf2 signaling pathway
1974. Differential effects of cisplatin combined with the flavonoid APIGENIN on HepG2, Hep3B, and Huh7 liver cancer cell lines
1975. Luteolin and APIGENIN derived glycosides from Alphonsea elliptica abrogate LPS-induced inflammatory responses in human plasma
1976. Prophylactic effect of myricetin and APIGENIN against lipopolysaccharide-induced acute liver injury
1977. APIGENIN inhibits the growth of hepatocellular carcinoma cells by affecting the expression of microRNA transcriptome
1978. APIGENIN Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways
1979. APIGENIN protects against ischemia-/hypoxia-induced myocardial injury by mediating pyroptosis and apoptosis
1980. Interaction between APIGENIN and sodium deoxycholate with raloxifene: A potential risk for clinical practice
1981. APIGENIN acts as a partial agonist action at estrogen receptors in vivo
1982. Chemopreventive Role of APIGENIN against the Synergistic Carcinogenesis of Human Papillomavirus and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
1983. An In Vitro-In Vivo Evaluation of the Antiproliferative and Antiangiogenic Effect of Flavone APIGENIN against SK-MEL-24 Human Melanoma Cell Line
1984. APIGENIN Improves Hypertension and Cardiac Hypertrophy Through Modulating NADPH Oxidase-Dependent ROS Generation and Cytokines in Hypothalamic …
1985. APIGENIN, a Partial Antagonist of the Estrogen Receptor (ER), Inhibits ER-Positive Breast Cancer Cell Proliferation through Akt/FOXM1 Signaling
1986. The effect of luteolin 7-glucoside, APIGENIN 7-glucoside and Succisa pratensis extracts on NF-κB activation and α-amylase activity in HepG2 cells
1987. APIGENIN Attenuates Mesoporous Silica Nanoparticles-Induced Nephrotoxicity by Activating FOXO3a
1988. Interaction of APIGENIN-7-O-glucoside with pyrimethamine against Toxoplasma gondii growth
1989. APIGENIN Reverses Interleukin‐1β‐Induced Suppression of Adipocyte Browning via COX2/PGE2 Signaling Pathway in Human Adipocytes
1990. Ecophysiological, anatomical, and APIGENIN changes due to uptake and accumulation of cadmium in Matricaria chamomilla L. flowers in hydroponics
1991. APIGENIN alleviates methotrexate-induced liver and kidney injury in mice
1992. Effects of APIGENIN and Astragalus Polysaccharide on the Cryopreservation of Bull Semen
1993. APIGENIN ameliorates hyperuricemic nephropathy by inhibiting URAT1 and GLUT9 and relieving renal fibrosis via the Wnt/β-catenin pathway
1994. APIGENIN ameliorates hepatic lipid accumulation by activating the autophagy-mitochondria pathway.
1995. APIGENIN inhibits the growth of colorectal cancer through down-regulation of E2F1/3 by miRNA-215-5p
1996. The potential protective role of APIGENIN against oxidative damage induced by nickel oxide nanoparticles in liver and kidney of male Wistar rat, Rattus norvegicus
1997. β-Amyloid Formation, Memory, and Learning Decline Following Long-term Ovariectomy and Its Inhibition by Systemic Administration of APIGENIN and β-Estradiol
1998. Combined effect of chrysin and APIGENIN on inhibiting the development and progression of colorectal cancer by suppressing the activity of P38‐MAPK/AKT pathway
1999. Protective mechanism of APIGENIN in diabetic nephropathy is related to its regulation of miR-423-5P-USF2 axis
2000. miR-34a-5p might have an important role for inducing apoptosis by down-regulation of SNAI1 in APIGENIN-treated lung cancer cells
2001. Investigation of oxidant/antioxidant and anti‐inflammatory effects of APIGENIN on apoptosis in sepsis‐induced rat lung
2002. APIGENIN/furfurylamine-based bio-polyamide derivative: Benzoxazine-isocyanide mechanochemistry preparation and application in Pb (II) electrochemical probing
2003. Effects of APIGENIN on the Expression of LOX‐1, Bcl‐2, and Bax in Hyperlipidemia Rats
2004. Inhibitory Effect of Acacetin, APIGENIN, Chrysin and Pinocembrin on Human Cytochrome P450 3A4.
2005. Comparison of diclofenac with APIGENIN-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in …
2006. Encapsulation and Characterization of Nanoemulsions Based on an Anti-oxidative Polymeric Amphiphile for Topical APIGENIN Delivery
2007. APIGENIN Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NAD-CD38 Axis
2008. APIGENIN attenuates myocardial infarction-induced cardiomyocyte injury by modulating Parkin-mediated mitochondrial autophagy
2009. … and Antiproliferative Activity of the Ethanolic Extract of Equisetum myriochaetum and Molecular Docking of Its Main Metabolites (APIGENIN, Kaempferol, and Quercetin) …
2010. Protective effect of myricetin, APIGENIN, and hesperidin pretreatments on cyclophosphamide-induced immunosuppression
2011. Evaluation of cholinesterase inhibitory and antioxidant activity of Wedelia chinensis and isolation of APIGENIN as an active compound
2012. Protection of APIGENIN against acrylonitrile-induced sperm and testis injury in rats: involvement of activation of ASK1-JNK/p38 signaling pathway
2013. Synergistic effect of Betulinic acid, APIGENIN and Skimmianine (BASk) in high cholesterol diet rabbit: Involvement of CD36-TLR2 signaling pathway
2014. APIGENIN Nanoparticle Attenuates Renal Ischemia/Reperfusion Inflammatory Injury by Regulation of miR-140-5p/CXCL12/NF-κB Signaling Pathway
2015. APIGENIN exerts chemopreventive effects on lung injury induced by SiO2 nanoparticles through the activation of Nrf2
2016. Flavones (APIGENIN, Luteolin, Chrysin) and Their Importance for Health
2017. Experimental Study on the Influence of APIGENIN K and Melatonin in Socket Preservation as Bone Stimulators: An Experimental Study in Beagle Dogs
2018. A single robust stability-indicating RP-HPLC analytical tool for APIGENIN quantification in bulk powder and in nanoliposomes: a novel approach
2019. LC-MS/MS Determination of APIGENIN in Rat Plasma and Application to Pharmacokinetic Study
2020. APIGENIN
2021. APIGENIN prevents gamma radiation-induced gastrointestinal damages by modulating inflammatory and apoptotic signalling mediators
2022. Tyrosinase and cholinesterase inhibitory activities and molecular docking studies on APIGENIN and vitexin.
2023. A comparative study of APIGENIN content and antioxidant potential of Cosmos bipinnatus transgenic root culture
2024. Investigating the in vitro photothermal effect of green synthesized APIGENIN‐coated gold nanoparticle on colorectal carcinoma
2025. Development and validation of an LC-MS/MS method for the quantification of flavonoid glucuronides (wogonoside, baicalin, and APIGENIN-glucuronide) in the bile and …
2026. APIGENIN suppresses proliferation, invasion, and epithelial–mesenchymal transition of cervical carcinoma cells by regulation of miR‐152/BRD4 axis
2027. An in vitro evaluation of APIGENIN and APIGENIN-7-o-glucoside against hela human cervical cancer cell line
2028. APIGENIN-7-Glucuronide from Urera aurantiaca Inhibits Tumor Necrosis Factor Alpha and Total Nitrite Release in Lipopolysaccharide-Activated Macrophages
2029. Sulfation of hesperetin, naringenin and APIGENIN by the human cytosolic sulfotransferases: a comprehensive analysis
2030. Comparative effects of quercetin, luteolin, APIGENIN and their related polyphenols on uric acid production in cultured hepatocytes and suppression of purine bodies …
2031. APIGENIN causes necroptosis by inducing ROS accumulation, mitochondrial dysfunction, and ATP depletion in malignant mesothelioma cells
2032. Co-administration of APIGENIN with doxorubicin enhances anti-migration and antiproliferative effects via PI3K/PTEN/AKT pathway in prostate cancer cells
2033. Protective effects of APIGENIN against Bisphenol A-induced testis toxicity in Wistar rats through modulating hepatic biochemical biomarkers and histological changes
2034. Novel Reverse-Phase High-Performance Liquid Chromatography (RPHPLC) Method for the Quantification of APIGENIN in Ocimum Basilicum Linn Seeds (Tukmaria)
2035. Proteome responses of Rhizobium tropici CIAT 899 upon APIGENIN and salt stress induction
2036. DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF APIGENIN AND LUTEOLIN IN COMMERCIAL …
2037. APIGENIN restores endothelial function by ameliorating oxidative stress, prevents foam cell formation, reverses aortic stiffening, and mitigates vascular inflammation …
2038. … Amyloid Formation, Memory, and Learning Decline Following Long-term Ovariectomy and Its Inhibition by Systemic Administration of APIGENIN and β-Estradiol
2039. Qualitative and quantitative analyses of labiatenic acid, APIGENIN and buddleoside in Hyssopus officinalis by high-performance thin-layer chromatography
2040. Evidence for 5‐HT1A receptor‐mediated antiallodynic and antihyperalgesic effects of APIGENIN in mice suffering from mononeuropathy
2041. APIGENIN Ameliorates Insulin Resistance and Lipid Accumulation by Endoplasmic Reticulum Stress and SREBP-1c/SREBP-2 Pathway in Palmitate-Induced HepG2 …
2042. H2O2-Scavenging Activity and Hyaluronidase Inhibition Scutellarein and APIGENIN in Ocimum basilicum Extract
2043. APIGENIN neutralizes the inhibitory effect of inflammation on the osteogenic differentiation of human mesenchymal stem cells
2044. Effects of APIGENIN, Luteolin, and Quercetin on the Natural Killer (NK-92) Cells Proliferation: A Potential Role as Immunomodulator
2045. Oleanolic Acid, Ursolic Acid and APIGENIN from Ocimum basilicum as Potential Inhibitors of the SARS-CoV-2 Main Protease: A Molecular Docking Study
2046. Identification of 3, 3′-O-dimethylellagic acid and APIGENIN as the main antiplasmodial constituents of Endodesmia calophylloides Benth and Hymenostegia …
2047. Anticalculi activities of APIGENIN hot melt extrusion results with soluplus® and kollidon® va 64 polymers on wistar rats
2048. Inhibition of CD38 by APIGENIN limits injury-induced osteoarthritis development and associated pain in mice
2049. Efficacy of Combination Therapy with APIGENIN and Synovial Membrane-Derived Mesenchymal Stem Cells on Knee Joint Osteoarthritis in a Rat Model
2050. APIGENIN Ameliorates Lead Acetate induced Hyperlipidemia, Hypothyroidism and Hypogonadism in Male Rats
2051. Hypoglycemic Effects of APIGENIN from Morus Indica in Streptozotocin Induced Diabetic Rats
2052. The Potential Role of APIGENIN in Diabetes Mellitus
2053. Development and Validation of UV-Visible Spectrophotometric Method for Estimation of APIGENIN in Parsley Leaves Extract
2054. Reactivation of maspin by plant flavone APIGENIN through inhibition of class I HDACs and increase in p53 transcriptional activity in prostate cancer cells
2055. Effect of APIGENIN on H2O2-induced oxidative injury in human hepatocytes L02
2056. FLAVONOID APIGENIN DARI EKSTRAK DAUN TUMBUHAN RUKAM (Flacourtia rukam) SERTA UJI AKTIVITAS ANTIOKSIDAN DAN ANTIBAKTERI
2057. A Study on the Interaction Between Kaempferol, APIGENIN and 4-Hydroxybenzoic Acid in Xanthine Oxidase Inhibition
2058. Study on Tissue Distribution of APIGENIN Nanosuspension in Mice
2059. Study on RAD51 Gene Regulatory Mechanism of APIGENIN Affecting Cisplatin Sensitivity to NSCLC A 549 Cells
2060. Effects of APIGENIN on the expression of antioxidant enzymes in Soleus and FDB muscle in animal model
2061. Synthesis of Silver Nano particles Using Catechin and APIGENIN and Study their Anti-oxidant Effect on the Laboratory Rats
2062. Corrigendum to” APIGENIN Prevents Deregulation in the Expression Pattern of Cell-Proliferative, Apoptotic, Inflammatory and Angiogenic Markers During 7, 12 …
2063. Extraction of APIGENIN from Parsley by Combined Treatments of Subcritical Water Extraction (SWE) with Pulsed Electric Fields (PEF) and Intense Pulsed Light (IPL)
2064. APIGENIN modulates immune checkpoint molecules in pancreatic cancer enhancing anti-tumor immunity
2065. The protective and Antioxidant Effect of Catechin and APIGENIN on Some Biochemical Parameters in Blood Serum of Rats Exposed to Oxidative Stress Induced by …
2066. APIGENIN Inhibits the Histamine-Induced Proliferation of Ovarian Cancer Cells by Downregulating ERα/ERβ Expression
2067. Spatial memory and microglia activation in a mouse model of chronic neuroinflammation and the anti-inflammatory effects of APIGENIN
2068. Synthesis of 7-O-alkyl or 7-O-acyl Derivatives of Naringenin and APIGENIN
2069. Preparation of radioiodine-131 labeled APIGENIN anti cancer compound for bioactivity study