DISEASE & DISORDERS

SUGAR & AGING

  A Role For Somatostatin In The Impaired insulin Secretory Response To glucose By Islets From Aging Rats A Study Of The Effect Of Aging On insulin And Glueagon Release During Intravenous glucose Tolerance Test Ability Of insulin To Modulate Hepatic glucose Production In Aging Rats Is Impaired By Fat Accumulation Accumulation Of Advanced glycation […]

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ALZHEIMER’S, DEMENTIA, PARKINSON’S

Neuroprotective effects of flavonoids and polyphenols   A berry thought-provoking idea: the potential role of plant polyphenols in the treatment of age-related cognitive disorders A bird’s-eye view of the multiple biochemical mechanisms that propel pathology of Alzheimer’s disease: recent advances and mechanistic perspectives on … A blueberry extract-supplemented diet rescues phenotypes in drosophila melanogaster models

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INFLAMMAGING

’Inflammaging’ refers to the chronic, low-grade inflammation that characterizes aging. Inflammaging is macrophage centered, involves several tissues and organs, including the gut microbiota, and is characterized by a complex balance between pro- and anti-inflammatory responses. Based on literature data, we argue that the major source of inflammatory stimuli is represented by endogenous/self, misplaced, or altered molecules

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MSG (MONSOSODIUM GLUTAMATE)

… -biochemical profile, and organs histology of broiler chickens fed diets supplemented with a seasoning named Jumbo Cube as source of monosodium glutamate … -D-aspartate receptor-, glutamate-and aspartate-immunoreactive neurons in the mouse arcuate nucleus: effects of neonatal treatment with monosodium glutamate … -releasing hormone synthesizing neurons in the hypothalamic paraventricular nucleus of rats neonatally treated

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NF-KB

018 Hif2A/Nf-Kb Signal In Chondrocytes Controls Extensive Steps Of Osteoarthritis Development In Mice And Humans 061 The Nf-Kb Pathway Component A20 (Tnfaip3) Is Commonly Inactivated By Dna Mutations And Deletions In Extranodal … 1, 25-Dihydroxyvitamin D3 Preserves Intestinal Epithelial Barrier Function From Tnf-Α Induced Injury Via Suppression Of Nf-Kb P65 Mediated Mlck-P-Mlc Signaling … 1024.

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ADVANCED GLYCATION END PRODUCTS (AGES)

Advanced glycation end products Key players in skin aging? Abstract Aging is the progressive accumulation of damage to an organism over time leading to disease and death. Aging research has been very intensive in the last years aiming at characterizing the pathophysiology of aging and finding possibilities to fight age-related diseases. Various theories of aging

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IL-6/STAT3

A Central Role For Stat3 In Il‐6‐Induced Regulation Of Growth And Differentiation In M1 Leukemia Cells. A High-Affinity Protein Binder That Blocks The Il-6/Stat3 Signaling Pathway Effectively Suppresses Non–Small Cell Lung Cancer A Muscle Specific Protein “Myoferlin” Modulates Il-6/Stat3 Signaling By Chaperoning Activated Stat3 To Nucleus A Muscle-Specific Protein ‘Myoferlin’Modulates Il-6/Stat3 Signaling By Chaperoning Activated

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STAT3

A cell-permeable STAT3 SH2 domain mimetic inhibitor of STAT3 activation inhibits growth of human breast tumor xenografts A cell-permeable STAT3 SH2 domain mimetic inhibits STAT3 activation and induces antitumor cell effects in vitro A low-molecular-weight compound discovered through virtual database screening inhibits STAT3 function in breast cancer cells A membrane penetrating peptide aptamer inhibits STAT3

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INFLAMMATION & DEPRESSION

    A biological pathway linking inflammation and depression: activation of indoleamine 2, 3-dioxygenase A human in vitro model to investigate the effects of inflammation on adult hippocampal neurogenesis in the context of depression A new paradigm for depression in new mothers: the central role of inflammation and how breastfeeding and anti-inflammatory treatments protect maternal

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INFLAMMATION & ANXIETY

… Adolescent Patients with Juvenile Idiopathic Arthritis, Anxiety and Mood Predicts Function Whereas Life Event Stressors in the Older Adolescent Predicts inflammation … association of somatic and cognitive symptoms of depression and Anxiety with inflammation: findings from the Netherlands Study of Depression and Anxiety … … depression after percutaneous coronary intervention are associated with decreased

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