12P Individualized Breast Cancer Therapy Using Mcl-1 Inhibition Based Combination 155: Trem-1 Protects Monocyte From Apoptosis Via Mcl-1-Dependent Mechanism 1-Phenyl-1H-Indole Derivatives As A New Class Of Bcl-2/Mcl-1 Dual Inhibitors: Design, Synthesis, And Preliminary Biological Evaluation 2-Deoxyglucose Pretreatment Sensitizes Colon Cancer Cells To Cisplatin And Killer Trail Induced Apoptosis By Mcl-1 Downregulation 3656: Apoptosis In Human […]
Neuroprotective effects of flavonoids and polyphenols A berry thought-provoking idea: the potential role of plant polyphenols in the treatment of age-related cognitive disorders A bird’s-eye view of the multiple biochemical mechanisms that propel pathology of Alzheimer’s disease: recent advances and mechanistic perspectives on … A blueberry extract-supplemented diet rescues phenotypes in drosophila melanogaster models
ALZHEIMER’S, DEMENTIA, PARKINSON’S Read More »
’Inflammaging’ refers to the chronic, low-grade inflammation that characterizes aging. Inflammaging is macrophage centered, involves several tissues and organs, including the gut microbiota, and is characterized by a complex balance between pro- and anti-inflammatory responses. Based on literature data, we argue that the major source of inflammatory stimuli is represented by endogenous/self, misplaced, or altered molecules
Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models Abstract Studying long-lived animals provides novel insight into shared characteristics of aging and represents a unique model to elucidate approaches to prevent chronic disease. Oxidant stress underlies many chronic diseases and resistance to stress is a potential mechanism governing slowed aging. The transcription factor
… -biochemical profile, and organs histology of broiler chickens fed diets supplemented with a seasoning named Jumbo Cube as source of monosodium glutamate … -D-aspartate receptor-, glutamate-and aspartate-immunoreactive neurons in the mouse arcuate nucleus: effects of neonatal treatment with monosodium glutamate … -releasing hormone synthesizing neurons in the hypothalamic paraventricular nucleus of rats neonatally treated
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018 Hif2A/Nf-Kb Signal In Chondrocytes Controls Extensive Steps Of Osteoarthritis Development In Mice And Humans 061 The Nf-Kb Pathway Component A20 (Tnfaip3) Is Commonly Inactivated By Dna Mutations And Deletions In Extranodal … 1, 25-Dihydroxyvitamin D3 Preserves Intestinal Epithelial Barrier Function From Tnf-Α Induced Injury Via Suppression Of Nf-Kb P65 Mediated Mlck-P-Mlc Signaling … 1024.
… -apoptotic activity of whole extract and isolated indicaxanthin from Opuntia ficus-indica associated with re-activation of the onco-suppressor p16INK4a gene in human … … -associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type-and insult-dependent manner and follow expression of p16INK4a … -mediated overexpression of p15INK4B inhibits human glioma cell growth, induces
… -1 CONVEYS TEMOZOLOMIDE RESISTANCE BY THE INHIBITING DNA DAMAGE RESPONSE PATHWAY THROUGH THE POLYCOMB REPRESSOR Bmi-1 … and inhibitory effects on cancer stem cell-like properties of Adeno-associated virus (AAV)-mediated Bmi-1 interference driven by Bmi-1 promoter for gastric … … butyrate inhibits migration and induces AMPK‐mTOR pathway‐dependent autophagy and ROS‐mediated apoptosis via the miR‐139‐5p/Bmi‐1 axis
… -activated protein kinase kinase kinase 3 (MEKK3) is required for lysophosphatidic acid (LPA)-mediated optimal i [kappa] B kinase [beta](IKK [beta])/nuclear factor … … -induced expression of iNOS and COX-2 in BV2 murine microglial cells: possible involvement of reactive oxygen species, p38 MAPK, and IKK/NF-κB signaling … … -insufficiency improves cardiac function in early-stages of
… . Specifically, genetic programming automatically created metabolic pathways involved in the phospholipid cycle and the synthesis and degradation of ketone bodies. … 3-phosphate O-acyltransferase and the concentrations of malonyl-CoA, non-esterified and esterified carnitine, glycerol 3-phosphate, ketone bodies and long-chain … … and buformin and their combination on body weight and several metabolic parameters in
