STOMACH RESET COMBO (Fix Virtually All Gastrointestinal Problems) Featuring: PURGE/ PARASLAYER/ HELICO

Name: STOMACH RESET COMBO (Fix Virtually All Gastrointestinal Problems) Featuring: PURGE/ PARASLAYER/ HELICO
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DIRECTIONS: Mix 1/2 teaspoon HELICO and PARASLAYER morning and night in plain unsweetened kefir.

PURGE dosage is 1/8 – 1/4 tsp as needed and be sure to stay near a toilet!!!! Be careful it’s POTENT!!!

100g bag PARASLAYER, HELIC0 & PURGE

200:1 Concentration

HELICOBACTER PYLORI

1 out of 2 people has IT

Heartburn? Indigestion? Irritable bowel syndrome? Gas? Nutrient absorption issues? Ulcers? Stomach problems in general? There’s a high probability you have this resistant little bacteria camping out in your stomach wreaking havoc.

“Helicobacter pylori, previously known as Campylobacter pylori, is a gram-negative, helically-shaped, microaerophilic bacterium usually found in the stomach.^[6] Its helical shape (from which the genus name, helicobacter, derives) is thought to have evolved in order to penetrate the mucoid lining of the stomach and thereby establish infection.^[7]^[8] The bacterium was first identified in 1982 by Australian doctors Barry Marshall and Robin Warren, who found that it was present in a person with chronic gastritis and gastric ulcers, conditions not previously believed to have a microbial cause.^[9]^[10]^[11] H. pylori has also been linked to the development of duodenal ulcers, polyps, i. e. benign growths, in the small intestine, large intestine, and rectum, and malignancies of the stomach’s secretory glands (termed stomach adenocarcinoma),^[12] of the mucosa-associated lymphoid tissue in the stomach, esophagus, colon, rectum, or tissues around the eye (termed extranodal marginal zone B-cell lymphoma of the cited organ),^[13]^[14]^[15] and of lymphoid tissue in the stomach (termed diffuse large B-cell lymphoma).^[16]

Many investigators have proposed causal associations between H. pylori and a wide range of other diseases (e.g. idiopathic thrombocytopenic purpura, iron deficiency anemia, atherosclerosis, Alzheimer’s disease,^[17] multiple sclerosis, coronary artery disease, periodontitis,^[18] Parkinson’s disease, Guillain–Barré syndrome, rosacea, psoriasis, chronic urticaria, spot baldness, various autoimmune skin diseases, Henoch–Schönlein purpura, low blood levels of vitamin B12, autoimmune neutropenia, the antiphospholipid syndrome, plasma cell dyscrasias, central serous chorioretinitis, open angle glaucoma, blepharitis, diabetes mellitus, the metabolic syndrome, various types of allergies, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, hepatic fibrosis, and liver cancer^[19]). The bacterial infection has also been proposed to have protective effects for its hosts against infections by other pathogens, asthma, obesity,^[17] celiac disease, inflammatory bowel disease,^[18] rhinitis, atopic dermatitis,^[20] gastroesophageal reflux disease,^[21] and esophageal cancer.^[21] However, these deleterious and protective effects have frequently been based on correlative rather than direct relationship studies^[18] and have often been contradicted by other studies that show either the opposite or no effect on the cited disease.^[19] Consequently, many of these relationships are currently regarded as questionable and in need of more definitive studes.^[17] They are not considered further here.

Some studies suggest that H. pylori plays an important role in the natural stomach ecology, e.g. by influencing the type of bacteria that colonize the gastrointestinal tract.^[22]^[19] Other studies suggest that non-pathogenic strains of H. pylori may be beneficial, e.g., by normalizing stomach acid secretion,^[23] and may play a role in regulating appetite, since the bacterium’s presence in the stomach results in a persistent but reversible reduction in the level of ghrelin, an hormone that increases appetite.^[23]

In general, over 50% of the world’s population has H. pylori in their upper gastrointestinal tracts^[5] with this infection (or colonization) being more common in developing countries.^[4] In recent decades, however the prevalence of H. pylori colonization of the gastrointestinal tract has declined in many countries. This is attributed to improved socioeconomic conditions: in the United States of America, for example, the prevalence of H. pylori, as detected by endoscopy conducted on a referral population, fell from 65.8 to 6.8% over a recent 10 year period while over the same time period in some developing countries H. pylori colonization remained very common with prevalence levels as high as 80%.^[24] In all events, H. pylori infection is usually asymptomatic, being associated with overt disease (commonly gastritis or peptic ulcers rather than the relatively very rarely occurring cancers) in less than 20% of cases.^[25].” – WIKI

Inflammation, DNA Damage, Helicobacter pyloriand Gastric Tumorigenesis

Helicobacter pylori (H. pylori) is a Gram negative bacterium that colonizes the stomach of almost half human population. It has evolved to escape immune surveillance, establishes lifelong inflammation, predisposing to genomic instability and DNA damage, notably double strand breaks. The epithelial host cell responds by activation of DNA damage repair (DDR) machinery that seems to be compromised by the infection. It is therefore now accepted that genetic damage is a major mechanism operating in cases of H. pylori induced carcinogenesis. Here, we review the data on the molecular pathways involved in DNA damage and DDR activation during H. pylori infection.

Helicobacter pylori-induced premature senescence

Helicobacter pylori, one of the most frequently observed bacterium in the human intestinal flora, has been widely studied since Marshall and Warren documented a link between the presence of H. pylori in the gastrointestinal tract and gastritis and gastric ulcers. Interestingly, H. pylori has also been found in several other epithelial tissues, including the eyes, ears, nose and skin that may have direct or indirect effects on host physiology and may contribute to extragastric diseases, e.g. chronic skin diseases. More recently, it has been shown that H. pylori cytotoxin CagA expression induces cellular senescenceof human gastric nonpolarized epithelial cells that may lead to gastrointestinal disorders and systemic inflammation. Here, we hypothesize that also chronic skin diseases may be promoted by stress-induced premature senescence (SIPS) of skin cells, namely fibroblasts and keratinocytes, stimulated with H. pylori cytotoxins. Future studies involving cell culture models and clinical specimens are needed to verify the involvement of H. pylori in SIPS-based chronic skin diseases.

H. pylori infection leads to an increased rate of diabetes

CONCLUSIONS We demonstrated for the first time that H. pylori infection leads to an increased rate of incident diabetes in a prospective cohort study. Our findings implicate a potential role for antibiotic and gastrointestinal treatment in preventing diabetes.

Proton Pump Inhibitors Accelerate Endothelial Senescence

Rationale: Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, which are now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal, and neurological morbidity.

Objective: To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in PPI-induced vascular dysfunction.

Methods and Results: Chronic exposure to PPIs impaired endothelial function and accelerated human endothelial senescence by reducing telomere length.

Conclusions:Our data may provide a unifying mechanism for the association of PPI use with increased risk of cardiovascular, renal, and neurological morbidity and mortality.

A new paradigm for GERD pathogenesis. Not acid injury, but cytokine-mediated inflammation driven by HIF-2α: a potential role for targeting HIF-2α to prevent and treat reflux esophagitis.

Traditionally, reflux esophagitis was assumed to develop as a caustic, chemical injury inflicted by refluxed acid. Recently, however, studies in rats and humans suggest that reflux esophagitis develops as a cytokine-mediated inflammatory injury, with hypoxia inducible factor (HIF)-2α playing a major role. In response to the reflux of acid and bile, HIF-2α in esophageal epithelial cells becomes stabilized, thereby increasing production of pro-inflammatory cytokines that attract T lymphocytes and other inflammatory cells to damage the esophagus. Recent studies have identified small molecule inhibitors of HIF-2α that demonstrate exquisite isoform selectivity, and clinical trials for treatment of HIF-2α-driven kidney cancers are ongoing. It is conceivable that a HIF-2α-directed therapy might be a novel approach to prevention and treatment of reflux esophagitis.

The Helicobacter pylori Urease Virulence Factor Is Required for the Induction of Hypoxia-Induced Factor-1α in Gastric Cells

Chronic Helicobacter pylori infection increases the risk of gastric cancer and induction of hypoxia-induced factor (HIF), which is frequently associated with the development and progression of several types of cancer. We recently showed that H. pylori activation of the PI3K-AKT-mTOR pathway in gastric cells increased HIF-1α expression. Here, we identified the H. pylori virulence factor responsible for HIF-1α induction. A mutant of the H. pylori 84-183 strain was identified with reduced ability to induce HIF-1α. Coomassie blue staining of extracts from these bacteria separated by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) revealed poor expression of urease subunits that correlated with reduced urease activity. This finding was confirmed in the 26695 strain, where urease mutants were unable to induce HIF-1α expression. Of note, HIF-1α induction was also observed in the presence of the urease inhibitor acetohydroxamic acid at concentrations (of 20 mM) that abrogated urease activity in bacterial culture supernatants, suggesting that enzymatic activity of the urease is not required for HIF-1α induction. Finally, the pre-incubation of the human gastric adenocarcinoma cell line AGS with blocking antibodies against Toll-like receptor-2 (TLR2), but not TLR4, prevented HIF-1α induction. In summary, these results reveal a hitherto unexpected role for the urease protein in HIF-1α induction via TLR2 activation following H. pylori infection of gastric cells.

INGREDIENTS:

Abrus cantoniensis (Fabaceae)

Impact Of Abrus Cantoniensis Ethanolic Extract On The Growth Inhibition Of Helicobacter Pylori
In Vitro Anti-Helicobacter Pylori Action Of 30 Chinese Herbal Medicines Used To Treat Ulcer Diseases
Progress In Use Of Natural Products And Their Active Components Against Helicobacter Pylori
Pharmacological ins and outs of medicinal plants against Helicobacter pylori: A review

Chinese conducted the antibacterial action of thirty herbal medicines, which have been frequently used since ancient times for the treatment of gastritis-like disorders (Li et al., 2005). Among those thirty tested Chinese herbs, the ethanol extracts of Saussurea lappa (Asteraceae), Abrus cantoniensis (Fabaceae) and Eugenia caryophyllata (Myrtaceae) had the most strongly bacteriostatic effect (MICs: approximately 40 mg/ml).

Agaricus bisporus extract

Ageratum conyzoides extract

In-vitro antimicrobial activity of Ageratum conyzoides (Linn) on clinical isolates of Helicobacter pylori
Pharmacological ins and outs of medicinal plants against Helicobacter pylori: A review

Ndip et al screened ten medicinal plants from Cameron against 15 clinical isolates by disk diffusion method and determine MIC and minimum bactericidal concentration (MBC) values. All the tested plants showed anti-H.pylori activity with inhibition zone diameters of 0-30 mm. Out of these, Ageratum conyzoides, Scleria striatinux and Lycopodium cernua showed potent anti-H. pylori activity with the lowest MIC and MBC of 0.032 mg/mL and 0.098 mg/mL respectively (Ndip et al., 2007).

Allicin

Angelica sinensis extract

Artemisia annua Extract

Anti-Helicobacter pylori Potential of Artemisinin and Its Derivatives

Bifidobacterium bifidum

Bombax malabaricum DC. Extract

Screening of anti-Helicobacter pylori herbs deriving from Taiwanese folk medicinal plants

Broccoli sprouts (sulforaphane)

Capsaicin

Carthamus tinctorious extract

In vitro Inhibition of Helicobacter pylori by Some Spices and Medicinal Plants Used in Iran

Cassia twig extract

Cinnamomi Ramulus ethanolic extract showed the potent antioxidant activity and cytotoxicity of Helicobacter pylori (H. pylori) and acid-neutralizing capacity.
Comparison of the antibacterial activities according to the extracting methods of Cinnamomum cassia against Helicobacter pylori
These results demonstrate that it can be successfully cured against H. pylori infection and protected from H. pylori-induced pathology with Cinnamomum cassia.

Celery Seed (novel unnamed component)

Coptis chinensis extract

Cranberry (Vaccinium macrocarpon)

Dateplum persimmon extrat

Decursin

Decursin And Decursinol Angelate Selectively Inhibit Nadh-Fumarate Reductase Of Ascaris Suum
Decursin Inhibits Tumor Growth, Migration, And Invasion In Gastric Cancer By Down-Regulating Cxcr7 Expression
Pharmacological ins and outs of medicinal plants against Helicobacter pylori: A review

First study of screening medicinal plants against H. pylori was published by Korean researchers who screened several medicinal plants against H. pylori and found extracts of Eugenia caryophyllata (flower), Coptidis japonica (rhizoma), Magnolia officinalis (cortex), Rheum palmatum (rhizoma) and Rhus javanica (galla rhois) had bacteriostatic effect on H. pylori. On further isolation of active constituents, the effects of decursinol angelate and decursin on bacterial inhibition were the most potent with minimum inhibitory concentrations (MICs) values of 6-20 mg/ml (Bae et al., 1998).

EGCG

Eugenia caryophyllata (CLOVES)

In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases
Pharmacological ins and outs of medicinal plants against Helicobacter pylori: A review.

Chinese conducted the antibacterial action of thirty herbal medicines, which have been frequently used since ancient times for the treatment of gastritis-like disorders (Li et al., 2005). Among those thirty tested Chinese herbs, the ethanol extracts of Saussurea lappa (Asteraceae), Abrus cantoniensis (Fabaceae) and Eugenia caryophyllata (Myrtaceae) had the most strongly bacteriostatic effect (MICs: approximately 40 mg/ml).
Eugenol: a potential phytochemical with multifaceted therapeutic activities

Fructus amomi extract

GALANGIN (Alpinia officinarum extract)

GENIPOSIDE (Fructus Gardeniae)

The Suppressive Effects of Geniposide and Genipin on Helicobacter pylori Infections In Vitro and In Vivo

Ganoderma lucidum extract

Golden cypress Cortex Phellodendri Chinensis) extract

Hawthorn (Crataegus pinnatifida) Extract

Juglans regia extract

Korean Red Ginseng extract

L. rhamnosus GG

Lactobacillus reuteri

Lions Mane Mushroom

Luteolin

Lycopodium cernua

In Vitro Anti-Helicobacter Pylori Activity Of Extracts Of Selected Medicinal Plants From North West Cameroon
In Vitro Anti-Helicobacter Pylori Activity Of Lycopodium Cernuum (Linn) Pic. Serm
Preliminary Phytochemical Screening And In Vitro Anti-Helicobacter Pylori Activity Of Extracts Of The Stem Bark Of Bridelia Micrantha (Hochst., Baill., Euphorbiaceae)
Role Of Phosphate Solubilizing Burkholderia Spp. For Successful Colonization And Growth Promotion Of Lycopodium Cernuum L.(Lycopodiaceae) In Lateritic Belt …
Pharmacological ins and outs of medicinal plants against Helicobacter pylori: A review

Ndip et al screened ten medicinal plants from Cameron against 15 clinical isolates by disk diffusion method and determine MIC and minimum bactericidal concentration (MBC) values. All the tested plants showed anti-H.pylori activity with inhibition zone diameters of 0-30 mm. Out of these, Ageratum conyzoides, Scleria striatinux and Lycopodium cernua showed potent anti-H. pylori activity with the lowest MIC and MBC of 0.032 mg/mL and 0.098 mg/mL respectively (Ndip et al., 2007).

Mangnolia officinalis extract

Anti-Helicobacter pylori activity and inhibition of gastritis by Magnolia officinalis extract

Mastic Gum extract

Oregano

Plumbago zeylanica L. extract

Anti-Helicobacter Pylori Activity Of Plumbago Zeylanica L.
Anti-Helicobacter Pylori And Cytotoxic Activity Of Detoxified Root Of Plumbago Auriculata, Plumbago Indica And Plumbago Zeylanica
High-Performance Liquid Chromatography For Quantification Of Plumbagin, An Anti-Helicobacter Pylori Compound Of Plumbago Zeylanica L.
Pharmacological ins and outs of medicinal plants against Helicobacter pylori: A review.

Researchers from Taiwan conducted a large scale study and employed fifty medicinal plants against H. pylori. While half of the employed plants showed bactericidal activity, five plants namely Anisomeles indica (L.) O. Kuntze, Bombax malabaricum DC., Paederia scandens (Lour.) Merr., Plumbago zeylanica L., and Alpinia speciosa (J. C. Wendl.) K. Schum demonstrated strong anti-H. pylori activities.

Polygonum cuspidatum extract

Anti-Helicobacter pylori compounds from Polygonum cuspidatum

Anti-Helicobacter pylori activity guided fractionation led to the isolation of five anthraquinones, two stilbenes and one naphthoquinone from the EtOAc fraction of Polygonum cuspidatum, using silica gel column chromatography, Sephadex-LH20, MPLC and recrystallization. The chemical structures were identified to be physcion (1), emodin (2), anthraglycoside B (3), trans-resveratrol (4), anthraglycoside A (5), polydatin (6), 2-methoxy-6-acetyl-7-methyljuglone (7) and citreorosein (8) by UV, ¹H-NMR, ¹³C-NMR and mass spectrometry. Anti-Helicobacter pylori activity including MIC values of each compound was evaluated. All of the isolates exhibited anti-H. pylori activity of which MIC values were lower than that of a positive control, quercetin. Compounds 2 and 7 showed potent growth inhibitory activity. Especially, a naphthoquinone, compound 7 displayed most potent antibacterial activity with MIC₅₀ value of 0.30 µM and MIC₉₀ value of 0.39 µM. Although anti–H. pylori activity of this plant was previously reported, this is the first report on that of compounds isolated from this species. From these findings, P. cuspidatum roots or its isolates may be useful for H. pylori infection and further study is needed to elucidate mechanism of action.

Punica granatum peel extract

Effects of Punica granatum pericarps and Quercus infectoria nutgalls on cell surface hydrophobicity and cell survival of Helicobacter pylori
Punica granatum is more effective to prevent gastric disorders induced by Helicobacter pylori or any other stimulator in humans
Study of In Vitro Inhibition Effect of Pomegranate Rind on H.pylori
In vitro Inhibition of Helicobacter pylori by Some Spices and Medicinal Plants Used in Iran

Helicobacter pylori is the most common cause of gastric infections worldwide. The antibacterial activity of methanol extracts of Satureja hortensis L. (Lamiaceae), Artemisia dracunculus L. (Asteraceae), Carthamus tinctorius L. (Asteraceae), Apium petroselinum L. (Apiaceae), Citrus sinensis L. (Rutaceae) and Punica granatum L. (Punicaceae) were evaluated against H. pylori. Inhibition tests were carried out using the disc diffusion method against 27 clinical isolates of H. pylori for initial screening and then agar dilution method to determine minimum inhibitory concentration (MIC). Among the crude extracts, P. granatum showed the highest inhibition (27.96±0.97mm) and the MICs of its butanol and aqueous fractions were 156 and 195.12 µg/mL, respectively. While its chloroform fraction had no activity against tested H. pylori isolates. All extracts except safflower preserved their anti-Helicobacter pylori activity at 121°C. All the extracts were capable of inhibiting the in in vitro growth of H. pylori and the butanol fraction of P. granatum, showed excellent anti-H. pylori activity

Resveratrol

Rheum officinale extract

Rhizoma coptidis extract

Comparison of Helicobacter pylori urease inhibition by Rhizoma Coptidis, Cortex Phellodendri and Berberine: mechanisms of interaction with the sulfhydryl group

Rottlerin (Mallotus philippinensis Muell. Arg (Euphorbiaceae)

Among the isolated compounds, rottlerin exhibited most potent bactericidal activity with minimum bactericidal concentration (MBC) value of 3.12-6.25 mg/l against several clinical H. pylori isolates including Japanese and Pakistani strains, nine clarithromycin resistant (CR), and seven metronidazole resistant (MR) strains.
Pharmacological ins and outs of medicinal plants against Helicobacter pylori: A review

We have conducted a study of fifty medicinal plants including twenty-five spices that are commonly prescribed for the treatment of gastrointestinal disorders in Unani medical practice in Pakistan (Zaidi et al., 2009a). MBC values determined were at the concentration range of 7.8 to 500 µg/ml using seven H. pylori clinical isolates and one ATCC reference H. pylori strain (ATCC 43504). It was interesting to note that >50% of herbs at the concentration of 500 µg/ml inhibited the growth of all H. pylori strains. Extracts of Mallotus phillipinesis (Lam) Muell., Curcuma amada Roxb., Psoralea corylifolia L. and Myrisctica fragrans Houtt showed strong anti-H. pylori activity (MBC: 15.6-62.5 µg/ml). The most potent extract (Mallotus phillipinesis (Lam) Muell) was further evaluated for active constituents and found rottlerin to possess strong MBC value range of 3.12-6.25 µg/ml even against geographically distinct Japanese strains and antibiotic resistant strains (Zaidi et al., 2009b).

Saccharomyces boulardii

Saussurea lappa (Asteraceae) Costus Root extract

Pharmacological ins and outs of medicinal plants against Helicobacter pylori: A review.

Chinese conducted the antibacterial action of thirty herbal medicines, which have been frequently used since ancient times for the treatment of gastritis-like disorders (Li et al., 2005). Among those thirty tested Chinese herbs, the ethanol extracts of Saussurea lappa (Asteraceae), Abrus cantoniensis (Fabaceae) and Eugenia caryophyllata (Myrtaceae) had the most strongly bacteriostatic effect (MICs: approximately 40 mg/ml).
Anti-microbial activity of Saussurea lappa CB Clarke Roots

Scutellaria baicalensis extract

Smilax glabra rhizome extract

Smoked plum (Fructus Pruni Mume) fruit extract

Tabebuia impetiginosa Martius ex DC dried inner bark (Menadione and plumbagin)

Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pylori.

The growth-inhibiting activity of Tabebuia impetiginosa Martius ex DC dried inner bark-derived constituents against Helicobacter pylori ATCC 43504 was examined using paper disc diffusion and minimum inhibitory concentration (MIC) bioassays. The activity of the isolated compounds was compared to that of the commercially available anti-Helicobacter pylori agents, amoxicillin, metronidazole, and tetracycline. The biologically active components of Tabebuia impetiginosa dried inner bark (taheebo) were characterized by spectroscopic analysis as 2-(hydroxymethyl)anthraquinone, anthraquinone-2-carboxylic acid, and 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol). With the paper disc diffusion assay 2-(hydroxymethyl)anthraquinone exhibited strong activity against Helicobacter pylori ATCC 43504 at 0.01 mg/disc. Anthraquinone-2-carboxylic acid, lapachol and metronidazole were less effective, exhibiting moderate anti-Helicobacter pylori activity at 0.1 mg/disc. Amoxicillin and tetracycline were the most potent compounds tested, displaying very strong activity at 0.005 mg/disc. 2-(Hydroxymethyl)anthraquinone exhibited moderate activity at this dose. Tetracycline still had strong activity at 0.001 mg/disc while amoxicillin had little activity at this dose. In the MIC bioassay, 2-(hydroxymethyl)anthraquinone (2 microg/mL), anthraquinone-2-carboxylic acid (8 microg/mL), and lapachol (4 microg/mL) were more active than metronidazole (32 microg/mL) but less effective than amoxicillin (0.063 microg/mL) and tetracycline (0.5 microg/mL). The anti-Helicobacter pylori activity of seven 1,4-naphthoquinone derivatives (structurally related to lapachol), 1,4-naphthoquinone, 5,8-dihydroxy-1,4-naphthoquinone (naphthazarin), 2-methyl-1,4-naphthoquinone (menadione), 2-hydroxy-1,4-naphthoquinone (lawsone), 5-hydroxy-2-methyl-1,4-naphthoquinone (plumbagin), 5-hydroxy-1,4-naphthoquinone (juglone), and 2,3-dichloro-1,4-naphthoquinone (dichlone) was also evaluated using the paper disc assay. Menadione and plumbagin were the most potent compounds tested with the later still exhibiting very strong activity at 0.001 mg/disc. Menadione, juglone and tetracycline had strong activity at this low dose while the latter two compounds and amoxicillin had very strong activity at 0.005 mg/disc. Lawsone was unusual in that it had very strong activity at 0.1 and 0.05 mg/disc but weak activity at doses of 0.01 mg/disc and lower. Naphthazalin, lapachol and dichlone had similar activities while metronidazole had the lowest activity of all compounds tested. These results may be an indication of at least one of the pharmacological actions of taheebo. The Tabebuia impetiginosa dried inner bark-derived materials, particularly 2-(hydroxymethyl)anthraquinone, merit further study as potential Helicobacter pylori eradicating agents or lead compounds.

tyrosol-elenolic acid dialdehyde (Ty-EDA or Ty-DEA) from Olive oil

In vitro activity of olive oil polyphenols against Helicobacter pylori.

Helicobacter pylori is linked to a majority of peptic ulcers and to some types of gastric cancer, and resistance of the microorganism to antibiotic treatment is now found worldwide. Virgin olive oil is an unrefined vegetable oil that contains a significant amount of phenolic compounds. Under simulated conditions, we have demonstrated that these substances can diffuse from the oil into the gastric juice and be stable for hours in this acidic environment. In vitro, they exerted a strong bactericidal activity against eight strains of H. pylori, three of them resistant to some antibiotics. Among the phenolic compounds, the dialdehydic form of decarboxymethyl ligstroside aglycon showed the strongest bactericidal effect at a concentration as low as 1.3 microg/mL. Although the experimental conditions are different from other reported works, this bactericidal concentration is much lower than those found for phenolic compounds from tea, wine, and plant extracts. These results open the possibility of considering virgin olive oil a chemopreventive agent for peptic ulcer or gastric cancer, but this bioactivity should be confirmed in vivo in the future.

Wasabi (Wasabia japonica) extract

Improvement Effects of Wasabi (Wasabia japonica) Leaves and Allyl Isothiocyanate on Stomach Lesions of Mongolian Gerbils Infected with Helicobacter pylori
The antimicrobial effects of Wasabia japonica and Armoracia rusticana, J Marine Biology and Aquascape
Leaf extract of Wasabia japonica relieved oxidative stress induced by Helicobacter pylori infection

Infection with Helicobacter pylori (H. pylori) can induce gastric disorders, and though its presence cannot explain disease pathogenesis and does not have associations with other factors, it is well known that H. pylori infection causes stomach inflammation following oxidative stress. We examined the suppressive effects of a leaf extract of Wasabia japonica on H. pylori infection and on stress loading in Mongolian gerbils. Following oral administration of wasabi extract of 50 and 200 mg/kg B.W./d for 10 d, the animals were exposed to restraint stress for 90 and 270 min. As for the results, the level of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) in the stomach and oxidative DNA damage in peripheral erythrocytes at 270 min significantly increased. That elevation was significantly suppressed by the addition of the leaf extract. We concluded that the simultaneous loading of H. pylori infection and physical stress loading might induce oxidative DNA damage additively, while a leaf extract attenuated this DNA damage in the stomach as well as the peripheral erythrocytes.
Pharmacological ins and outs of medicinal plants against Helicobacter pylori: A review

Shin et al from Japan reported anti-H. pylori activity of wasabi (Wasabia japonica) and demonstrated higher bactericidal activity of leaves than root of wasabi (Shin et al., 2004).

Zinc Carnosine

A modified sequential regimen of Helicobacter pylori treatment enforced by Bacillus clausii and Zinc Carnosine complex yields high eradication rates

Introduction: Over the past decade a worldwide trend of decline in the cure rates of Helicobacter pylori is observed. Current eradication rates achieved by the standard triple therapy are below 70%. Sequential therapy had provided a potential alternative that would compensate for the unmet performance of triple therapy. Despite its superiority to triple therapy, the excellent results reported initially were not reproduced by other investigators work. Adding adjuvant agents was also found to improve further the success rate of eradication. Probiotics emerged as a useful adjunct in treatment and prophylaxis of Helicobacter pylori infection. The nutritional supplement Zinc carnosine complex is another adjuvant which is believed to add value to the treatment. Patients and method: an open label randomized observational clinical study designed to compare the efficacy of a modified sequential regimen enforced by two adjuvants the probiotic Bacillus clausii and the nutritional Zinc Carnosine supplement. Patients who fulfilled the inclusion and exclusion criteria were randomized to one of two groups who were given the same components of the regimen of treatment either with clarithromycin (group A, n=131) or levofloxacin replacing it (group B, n=137) and were compared against the current reported response to triple therapy in our area (67.9%). Results: This regimen of eradication had yielded a Per protocol cure rate of 96.4% and an ITT rate of 89.9% for the levofloxacin based therapy. The Per protocol eradication rate for the clarithromycin based treatments was 93.4% and the ITT rate was 90%. The response was not significantly affected by previous exposure to the antibiotics used. Patient satisfaction and compliance were remarkable with most patients having a significant feeling of wellbeing and improvement of their symptoms. Side effects to the components of the regimen were unremarkable. The addition of Bacillus clausii and the nutritional supplement Zinc Carnosine had added great value to the eradication response.

Scientific Studies:

“Helico works right away in killing Helicobater Pylori! I’ve been trying to get rid of this for years. The first side effects were not pleasant as the bacteria put up a fight. BUT after about 3 days I started getting better. I used to feel exhausted every time I ate. This no longer happens. I expect to see better and better health results now that the bacteria is gone. Thank you Gavin for your endless supply of info and support. You are much appreciated!”

⭐️⭐️⭐️⭐️⭐️

—Shelley McKone

Introducing

INTERSTELLAR PARASLAYER ANTIHELMINTIC!

200:1 Concentration

Anthelmintics are a group of antiparasitic agents that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host.

KILL THE WORMS!

Featuring: Acacia Catechu • Acacia Nilotica • Acalypha Rhomboidea • Achyranthes Aspera • Acorus Calamus • Ajania Nubigena • Akanda (Calotropis Gigantea L.) • Albendazole • Albizia Anthelmintica Maerua Edulis • Albizia Gummifera • Allophylus Serratus • Alocasia Indica • Alpinia Galanga • Alstonia Boonei De Wild • Amaranthus Caudatus • Amaranthus Spinosus • Amorphophallus Paeoniifolius Tuber • Anaphalis Lawii • Annona Reticulata • Anthocleista Djalonensis . • Argemone Mexicana • Arisaema Lobatum • Aristolochia Indica • Artemisia Maritima • Artemisia Parviflora • Artemisia Vestita Wall Ex Dc • Artocarpus Lakoocha • Asparagus Racemosus • Asuro (Justicia Adhatoda) • Asystasia Gangeticum • Averrhoea Carambola • Azadirachta Indica • Baccaurea Ramiflora • Bacillus Cereus • Balanites Aegyptiaca • Baliospermum Montanum Muell • Barleria Gibsoni Dalz • Bauhinia Purpurea • Berlina Grandiflora • Biophytum Petersianum • Bougainvillea Glabra • Bridelia Ferruginae • Bryophyllum Pinnatum • Bryophyte Pottia Lanceolata • Caesalpinia Crista • Caesalpinia Pulcherrima • Caesalpinia Sappan • Cajanus Cajan • Camellia Sinensis • Canarium Schweinfurthii • Cansjera Rheedii Root Extract • Capparis Spinosa • Cardanthera Difformis Druce • Carica Papaya • Carissa Carandas • Carum Copticum • Cassia Fistula • Cassia Siamea Lamk • Cassia Tora • Castor Oil And Mustard Oil • Chenopodium Album • Chlorophytum Borivilianum Santapau • Chromolaena Odorata • Cissampelos Pareira • Cissus Quadrangularis L. • Citrus Medica • Clerodendrum Viscosum • Cloris Barbata • Coleus Aromaticus Benth • Coriandrum Sativum • Curcuma Longa Cyperus Rotundus • Dioscorea Bulbifera • Diplazium Esculentum • Drosera Regia • Drynaria Quercifolia • Eclipta Prostrate • Eichhornia Crassipes Roots • Elytraria Acaulis • Emblliaribes • Enicostemma Littorale Blume • Equisetum Arvense • Eucalyptus Globulus • Eugenia Jambolana • Eupatorium Triplinerve • Euphorbia Helioscopia • Euphorbia Ligularia Roxb • Evolvulus Alsinoides L • Ficus Vasta • Garcinia Cambogia • Goniothalamus Sesquipedalis • Gossypium Herbaceum • Grape Pomace Extract • Guava • Hedychium Spichatum • Helicteres Isora • Hugonia Mystax • Indigofera Oblongifolia • Iris Hookeriana • Ixora Coccinea • Jasminum Sessiliflorum • Juglans Regia • Justicia Beddomei • Kyllinga Nemoralis • Lagenaria Siceraria • Lanata Camara • Lasia Spinosa • Macrotyloma Uniflorum • Majoon Sarakhs • Malabathricum Linn Leaves And Nigella Sativa • Mallow (Malva Sylvestris L.) • Marine Sponge Extracts • Melia Azedarach • Melothria Heterophylla Lour • Memecyclon Malabaricum • Mentha Longifolia • Microphyllus Leaves • Millettia Pachycarpa • Mitragyna Parvifolia • Molineria Recurvata • Momordica Charantia • Momordica Dioica • Morinda Citrifolia • Myristica Fragrans • Nauclea Diderrichii • Neolamarckia Cadamba • Nepeta Cataria Suhaib • Nerium Oleander • Nigella Sativa • Nymphaea Rubra • Ocimum Basilicum • Ocimum Sanctum • Olea Europaea • Oleandra Musifolia • Pajanelia Longifolia • Paris Polyphylla • Pavetta Indica • Pelletíerine And Isopelletierine • Pineapple Leaf • Piper Betle • Piper Longum L • Plumbago Zeylanica • Pongamia Glabra • Prosopis Cineraria • Raphanus Sativus • Rhizophora Apiculata • Ridge Gourd • Rotula Aquatica Lour Bark • Rumex Hastatus • Saba Florida • Saraca Indica • Sesamum Indicum • Shea (Vitellaria Paradoxa) • Solanum Nigrum • Solanum Surattense • Soymida Febrifuga • Sterculia Villosa • Syzygium Aromaticum • Tectona Grandis • Tephrosea Purpurea • Terminalia Citrina Leaves • Trapa Natans • Trianthema Portulacastrum And Musa Paradisiaca • Tridax Procumbens • Trigonella Foenum-Graecum • Trikatu Churna • Tulsi Leaves [Ocimum Sanctum] • Vepris Louisii Gilbert • Vidangadi Churna • Viscum Congolensis • Vitex Trifolia • Xanthium Indicum Leaves • Ximenia Americana • Zanthoxylum Armatum • Zizyphus Jujuba Mill •

INGREDIENTS & Science:

Acacia Catechu

Investigation of anthelmintic, anti-inflammatory activity of leaves extract of Acacia catechu Willd

From ancient time Acacia catechu Willd. (AC) is used as a potent medicinal. Preliminary phytochemical tests were conducted with the crude extract obtained from the leaves of AC reveals the presence of carbohydrates, steroids, alkaloids, glycosides, tannins, saponins, flavones, and phenolic. anthelmintic activity of petroleum ether, ethanolic and ethanol:water (1:1) extracts of leaves of AC was evaluated by adult Indian earthworm, (Pheretima posthuma). The anthelmintic activity of extract was compared with standard albendazole.

Ethanol:water (1:1) extract was found to possess potent anthelmintic activity and petroleum ether extract was found to be least active, while ethanol:water (1:1) extract playing an intermediate role. The anti-inflammatory activity of leaves extracts at the doses of 300mg/kg body weight was investigated in albino rats of wiester strain using carrageenan induced rat paw oedema. The ethanol extract of leaves showed significant anti-inflammatory activity (45%) when compared with the standard (54%). Further studies are suggested to isolate the active principles which are responsible for the anthelmintic and anti-inflammatory activity.

Acacia Nilotica

IN VITRO PHYTOCHEMICAL ANALYSIS AND anthelmintic ACTIVITY OF ACACIA NILOTICA WHOLE PLANT METHANOLIC AND AQUEOUS EXTRACT ON INDIAN ADULT earthworm

anthelmintic activity, Acacia nilotica, Pheretimaposthuma, methanol extract, aqueous extract, phytochemical analysis There are various beneficial effects of Acacia nilotica since the ancient time is being reported. But in the project work anthelmintic activity against Pheretimaposthuma (an Indian earthworms is being studied by applying two different concentrations of plant methanolic extract. The result is then compared with standard drug Albendazole and control group. The pharmaceutical constituent of Acacia nilotica is being also studied here.

Achyranthes Aspera

In-vitro anthelmintic Activity of Methanolic and Aqueous Extracts of Achyranthes aspera linn. (Amaranthaceae) Stems

The anthelmintic activities of methanolic and aqueous extracts of stems of Achyranthes aspera linn. were evaluated separately on Indian adult earthworms Pheretima posthuma (Annelida). For this work the stems were extracted separately with methanol and distilled water by following maceration method. Various concentrations (2.5, 5, 10, 20 mg/ml) of each extract were tested for anthelmintic activity which involved the determination of time of paralysis and time of death of the worms. The phytochemical screening of the crude extract showed the presence of saponins A and B, terpenoids, volatile oils. All extracts were able to show anthelmintic activity at all concentrations.

The activities are well comparable with the standard drug, Albendazole as positive control. All the methanolic extracts showed better anthelmintic activity than the standard drug as well as the aqueous extract. Tween 20 (1%) with saline was used as negative control, did not showed any anthelmintic activity.

Acorus Calamus

anthelmintic activity of a standardized extract from the rhizomes of Acorus calamus Linn. (Acoraceae) against experimentally induced cestodiasis in rats

The study revealed that b-asarone is the active principle of plant. The HPLC analysis of local variety of A. calamus revealed that active fraction contains 83.54% (w/w) of b-asarone. The in vivo study revealed that treatment of H. diminuta infected rats by a single 800 mg/kg dose of rhizome extract for 5 days results into 62.30% reduction in eggs per gram of feces counts and 83.25% reduction in Worm counts of animals. These findings compared well with the efficacy of a reference drug, praziquantel. The active principle b-asarone showed slightly better anthelmintic effects than crude extract. In acute toxicity assay, a single oral 2000 mg/kg dose of extract did not reveal any signs of toxicity or mortality in mice, and the LD50 of the extract was noted to be >2000 mg/kg.

Taken together, the results of this study indicate that rhizomes of A. calamus bear significant dose-dependent effects against intestinal helminths. Further, the Indian variety of A. calamus contains high b-asarone content. Therefore, there exists a great potential to develop some suitable anthelmintic herbal products from this plant.

Ajania Nubigena

Compounds Derived from the Bhutanese Daisy, Ajania nubigena, Demonstrate Dual anthelmintic Activity against Schistosoma mansoni and Trichuris muris

Background: whipworms and blood flukes combined infect almost one billion people in developing countries. Only a handful of anthelmintic drugs are currently available to treat these infections effectively; there is therefore an urgent need for new generations of anthelmintic compounds. Medicinal plants have presented as a viable source of new parasiticides Ajania nubigena, the Bhutanese daisy, has been used in Bhutanese traditional medicine for treating various diseases and our previous studies revealed that small molecules from this plant have antimalarial properties. Encouraged by these findings, we screened four major compounds isolated from A. nubigena for their anthelmintic properties.

Akanda (Calotropis Gigantea L.)

In-vitro anthelmintic activity of Akanda (Calotropis gigantea L.) whole plant methanolic extract in Indian adult earthworm

After done all observation it may conclude that of Calotropis gigantean did produce very anthelmintic activity against India earthworms. During study this plant showed very significant anthelmintic activity at 100 mg/dl Conc. measured by time taken for paralyse / death of the earth worms. The result of different conc. of methanolic extracts of plants can compared with the rules of standard drug, Albendazole and Carboxy Methyl Cellulose (CMC) acts as a control. Future details research work on this plant will open a new avenue of drug industries.

Albendazole

Albendazole: a review of anthelmintic efficacy and safety in humans

This comprehensive review briefly describes the history and pharmacology of albendazole as an anthelminthic drug and presents detailed summaries of the efficacy and safety of albendazole’s use as an anthelminthic in humans. Cure rates and 0% egg reduction rates are presented from studies published through March 1998 both for the recommended single dose of 400 mg for hookworm (separately for Necator americanus and Ancylostoma duodenale when possible), Ascaris lumbricoides, Trichuris trichiura, and Enterobius vermicularis and, in separate tables, for doses other than a single dose of 400 mg. Overall cure rates are also presented separately for studies involving only children 2-15 years. Similar tables are also provided for the recommended dose of 400 mg per day for 3 days in Strongyloides stercoralis, Taenia spp. and Hymenolepis nana infections and separately for other dose regimens. The remarkable safety record involving more than several hundred million patient exposures over a 20 year period is also documented, both with data on adverse experiences occurring in clinical trials and with those in the published literature and/or spontaneously reported to the company.

The incidence of side effects reported in the published literature is very low, with only gastrointestinal side effects occurring with an overall frequency of just >1% . Albendazole’s unique broad-spectrum activity is exemplified in the overall cure rates calculated from studies employing the recommended doses for hookworm (78% in 68 studies: 92%, for A. duodenale in 23 studies and 75% for N. americanus in 30 studies), A. lumbricoides (95% in 64 studies), T. trichiura (48% in 57 studies), E. vermicularis (98% in 27 studies), S. stercoralis (62% in 19 studies), H. nana (68% in 11 studies), and Taenia spp. (85% in 7 studies).

The facts that albendazole is safe and easy to administer, both in treatment of individuals and in treatment of whole communities where it has been given by paramedical and nonmedical personnel, have enabled its use to improve general community health, including the improved nutrition and development of children.

Albizia anthelmintica Maerua Edulis

Pharmacological and clinical evaluation anthelmintic activity of albizia anthelmintica maerua edulis de wolf and maerua subcordata plant extracts in sheep and mice

The use of medicinal plants for the control of helminthoses has been in practice for centuries and there are many plants claimed to have anthelmintic activity. However, it is only a few of these plants that have their anthelmintic activity scientifically evaluated. These studies were done to evaluate the anthelmintic activity of Albizia anthelmintica Brogn, Maerua edulis De Wolf and Maerua subcordata De Wolf in sheep and mice and to determine the bioactivity of these plants using brine shrimp lethality test. An attempt was also made to separate the pharmacological active ingredient in Albizia anthelmintica water extract. A questionnaire was used to obtain medicinal plants used by farmers and herbalists in Kibwezi Division of Makueni district and Tunyo division of Marakwet district as anthelmintic. Out of 51 useful plants identified in Kibwezi, Albizia anthelmintica (Kyoa in Kikamba) and Maerua edulis (Munatha in Kikamba) were singled out by herbalists as very potent anthelmintics. In Tunyo division Albizia anthelmintica (Kitwongwo in Marakwet) and Maerua subcordata (Liswa in Marakwet) were identified as potent anthelmintics.

For this reason, they were collected and botanically identified for further testing and analysis. The anthelmintic activity of the three plants was evaluated in the present study. Crude extraction of the plant samples was done as described by the herbalists. An aqueous extract from both unground and ground material of each plant material was prepared using boiling water. Twenty one clinically healthy sheep of mixed breeds and sexes were randomly allocated to four treatment groups of four animals each. The control group had three sheep. Faecal egg counts were done for all the sheep on day O. A single oral dose of 1.2 ml/kg body weight (Albizia anthelmintica ) and 0.8 ml/kg body weight (Maerua edulis) was administered to the sheep in the 4 treatment groups. The control was left untreated. Albizia anthelmintica extract was the only one which reduced faecal egg count. At double the dose, the percentage faecal egg count reduction was 55, 49, 38, 16 and 14 for powdered Albizia anthelmintica, powdered Maerua edulis, fresh Maerua subcordata, fresh Maerua edulis and fresh Albizia anthelmintica respectively.

Therefore, the crude product could control helminthoses to a reasonable extent and maintain the animal at clinically healthy state. Brine shrimp assay was used to detect bioactivity (LC50) in the vanous extracts of Albizia anthelminitica, Maerua subcordata and Maerua edulis. The various extracts were made using water, methanol and chloroform and immediately freeze dried. Brine shrimp eggs obtained from pet shops were hatched using marine salt solution as media and yielded a large number of larvae. Serial dilution of the plant extracts were put into tubes with 10 brine shrimps each. The number of live larvae was determined after 24 hours. Probit method of the Finney computer programme was used to determine the lethal concentration fifty (LC50) and 95% confidence intervals. It was evident that the chloroform extract of the three plant extracts was the most toxic to the brine shrimps compared to water and methanol extracts. Albizia anthelmintica extracts of all the solvents was the most potent compared with the two Maerua species. The anthelmintic efficacy of the three plants was studied in mice experimentally infected with Heligmosomoides polygyrus.

The results indicated a percentage faecal xv Heligmosomoides polygyrus egg count reduction of 72%, 69%, 50%, 42% using water extracts of Albizia anthelmintica at 10gm/kg bodyweight, Maerua edulis at 20gm/kg bodyweight, Albizia anthelmintica at 20gm/kg bodyweight and Albizia anthelmintica at 5gmlkg bodyweight respectively. Seven days after treatment there was a reduction in Worm counts at postmortem of 68%, 36%, 20%, 19%,16% and 14% for water extracts of Albizia anthelmintica at 5gmlkg bodyweight, Maerua edulis at 10gmlkg bodyweight, Albizia anthelmintica at 10gmlkg bodyweight, Albizia anthelmintica at 20gm/kg bodyweight, Maerua edulis at 20gm/kg bodyweight and Maerua edulis at 5gm/kg bodyweight respectively. Mice treated with Albizia anthelmintica at 5gm/kg bodyweight had a significantly lower mean Worm counts than the rest of the treatment groups and the control (p<0.05).There was insignificant reduction in Worm counts for other treatment groups compared with the control (p<0.05). The column and thin layer chromatography done on the aqueous extract of Albizia anthelmintica yielded only one fraction which was active and had a relative fraction (Rf) of 0.75.

The results therefore indicate that the plant have some anthelmintic activity though low with Albizia anthelmintica being most efficacious. The bioactive fraction in Albizia anthelmintica obtained through chromatographic techniques indicate that there is a rationale in the use of this plant as an anthelmintic by the pastoralists. There is therefore a need to identify the active ingredient in Albizia anthelmintica for future commercial use.

Albizia Gummifera

In vitro anthelmintic activity of Albizia gummifera, Crotalaria axillaris, Manilkara discolor, Teclea trichocarpa and Zanthoxylum usambarense using sheep nematodes

Albizia gummifera, Crotalaria axillaris, Manilkara discolor, Teclea trichocarpa and Zanthoxylum usambarense are used to treat different ailments in many parts of the world. For instance, A. gummifera is used to treat stomach pains, malaria, diarrhoea and sleeping sickness while C. axillaris treats ophthalmic disorders and kidney problems. Manilkara discolor stem bark infusion is used to treat stomach disorders and as an astringent while T. trichocarpa has been used to treat malaria, helminth infections and fever. Zanthoxylum usambarense is used to treat rheumatism, backache, painful joints, fever, sore throat, tonsillitis, chest pains, malaria, abscesses and wounds.

Objective : The aim was to determine whether the crude plant extracts have in vitro anthelmintic activity.

Materials and methods : Different parts of the plants were acquired from Ngong Hills forest, Kajiado County, Kenya in May 2012, dried and macerated to exhaustion with dichloromethane: methanol (1:1, v/v) solution. nematode eggs ( Haemonchus Spp, Trichostrongylus Spp and Oesophagostomum Spp) were obtained from infected sheep rectums at Department of Vet Farm, University of Nairobi based at Kabete. Varying concentrations of water solutions of the dry crude extracts were prepared. Egg hatch (EHA) and larvae development assays (LDA) were used to test the extracts’ effects on nematode egg hatching and larvae development, respectively Results : Albizia gummifera (root bark) and Zanthoxylum usambarense (stem bark) showed high activity (IC 50 below 300 μg / mL) in both tests. Albizia gummifera (root, stem bark and pods), Zanthoxylum usambarense root bark, Crotalaria axillaris twigs and Teclea trichocarpa root and stem bark showed high activity in LDAbut moderate activity (300 μg / mL 500 μg / mL) activity in EHA. Manilkara discolor extracts showed low activity in both tests.

Conclusion: Different extracts of the plants tested may inhibit nematode growth and development and hence warrant in vivo tests would support their ethnomedicinal application. Key words: anthelmintic activity, egg hatch, larval development, Haemonchus, Trichostrongylus, Oesophagostomum

Allophylus Serratus

SCREENING OF IN-VITRO anthelmintic ACTIVITY OF ALLOPHYLUS SERRATUS (ROXB.) KURTZ ON INDIAN earthworms

Aim: The study was aimedto evaluate the In-Vitro anthelmintic activity of Allophylus serratus on Indian earthworms.

Materials &Methods: Differentconcentrations like 100mg/ml, 200mg/ml and 400mg/ml of Allophylus serratus leaf extract with ethanol were taken and were tested for time of paralysis and time of death in the worms according to the method Ajaiyeoba et al.

Results: Itshowed that all the concentrations of Allophylus serratus had anthelmintic activity according to the dose dependant manner. Efficacy of the test samples were found to be decreased the time for paralysis & death of the worms with increased dose. The test samples were compared with the standard drug Albendazole (20mg/ml) showed that the test concentration of 400mg/ml had equalled potent with standard drug.

Conclusion: The extract of 400mg/ml dose had potent anthelmintic activity than other extracts like 100mg/ml, 200mg/ml. On phytochemical screening of Allophylus serratus extract with ethanol was found to be phenolic compounds, flavonoids, tri-terpenoids, steroids and Glycosides. The study concluded that Allophylus serratus used as an anthelmentic drug in future.

Alocasia Indica

anthelmintic activity of leaves of Alocasia indica Linn.

The study was designed to evaluate the anthelmintic activity of hydroalcoholic extract of leaves of Alocasia indica Linn. (Araceae) and its two different fractions namely petroleum ether and ethyl acetate using Pheretima posthuma as test Worms. Different concentrations (10, 25 and 50 mg/ml) of hydroalcoholic extract and its various fractions were tested in the bioassay, from which time of paralysis (P) and time of death (D) of the worms were determined. Piperazine citrate was used as standard reference and distilled water as control. All the extracts were found not only to paralyze (Vermifuge) but also to kill the earthworms (Vermicidal).

The hydroalcoholic extract was found to be more effective to execute the earthworm at higher concentration of 50 mg/ml, as compared to standard reference Piperazine citrate. Further, systematic scientific studies are essential for screening different activities.

Alpinia Galanga

Phytochemical and anthelmintic activity of Alpinia galanga Linn

Plants have been one of the important sources of medicines even since the damn of human civilization. Alpinia galanga L. (Family-Zingiberaceae). It is well known official drug thought the country as a holistic gift of nature for medicinal, culinary and cosmetic use. It has been found to possess various therapeutic activities, viz. anti-inflammatory, analgesic ant allergic, antifungal, ant diabetic, antibacterial, antiulcer, immunostimulating, anti-cancer, anti -oxidant, anti-amoebic, anti-dermatophytic and many more. For different concentrations (100, 60, 40, 20mg/ml) of each extract(aqueous extract) were studied in activity which involved the determination time of paralysis (vermifuge) and time death ( vermicidal) of the worms Piperazine adipate in the same concentration as the extract was included as standard reference and normal saline (0.9%NaCl) water with 1% CMC as control.

The extract exhibited significant anthelmintic activity at a concentration of 100mg/ml in this case it was found that aqueous extract gives better activity compared to the standard. Results showed that Alpinia galanga rhizome extract gives better anthelmintic activity at all the tested doses.

Alstonia Boonei De Wild

In vitroanthelmintic activity of stem and root barks of Alstonia boonei De Wild

Alstonia booneiDe Wild ethanol extracts of the stem bark (ABSB) and root bark (ABRB)were evaluated for possible anthelmintic activity. Three different concentrations of each extract (50, 100 and 150mg/ml) were evaluated for in vitroanthelmintic activity by determining the effects of the extracts on the paralysis and death times of Pheretima posthuma.Mebendazole(MBZ) 15 mg/mg was used as reference anthelmintic. ABSB and ABRBdemonstrated a concentration dependent anthelmintic activity with a reduction in paralytic anddeath times upon increase in theconcentrationof the extracts.

ABSB revealedbetteranthelmintic activity than ABRBat all concentrations tested. ABSB also revealeda significant paralytic time (p<0.01) at 150mg/mlwith reference to MBZ. Phytochemical screening revealed the presence ofalkaloids, tannins, flavonoids saponins and glycosides in ABSBand ABRB.

Amaranthus Caudatus

anthelmintic activity of methanol extract of Amaranthus caudatus Linn

Amaranthus caudatus Linn, traditionally used as vermifuge, so methanol extract of whole plant of A. caudatus was investigated for anthelmintic activity using earthworms (Pheretima posthuma). Various concentrations (10-100 mg/ml) of methanol extract were tested in the bioassay. Piperazine citrate (10 mg/ml) was used as reference standard drug whereas distilled water as control. Determination of paralysis time and death time of the Worms were recorded. Extract exhibited

significant dose dependent anthelmintic activity at 60, 80, 100 mg/ml. The result provides scientific validation for traditional use.

Amaranthus Spinosus

Evaluation of anthelmintic and anti-inflammatory activity of Amaranthus spinosus Linn

Water extracts of whole plant of Amaranthus spinosus Linn was evaluated for anthelmintic on adult Indian earthworms (Pheritima posthuma) and Tubifex tubifex ,using piperazine citrate as reference standard. Aqueous extract showed anthelmintic activity in dose‐dependent manner giving shortest time of paralysis(P) and death(D) with 50 mg/ml concentration, for both the worms. Extract shows more potent activity (15 mg/ml) against Tubifex tubifex. Extract shows more potent activity (15 mg/ml) against Tubifex tubifex.

The petroleum ether and ethanolic extracts of whole plant of Amaranthus spinosus Linn. were tested for anti‐inflammatory activity at the dosed of 250,500 and 750 mg/kg body weight.The extract produced dose dependent and significant inhibition of carrageenan induced paw oedema. The exhibited anti‐inflammatory activity of this plant was comparable with the standard drug Ibuprofen.The presence of steroids, alkaloids & flavonoids in the extracts may be contributory to its antiinflammatory activity.

Amorphophallus Paeoniifolius Tuber

Evaluation of anthemintic activity of the methanolic extract of Amorphophallus paeoniifolius tuber

Methanolic extracts of the tuber of Amorphophallus paeoniifolius were investigated for its antihelmintic activity against Pheretima posthuma and Tubifex tubifex. The extract with the concentrations of 25, 50 and 100 mg/ml were tested in the bioassay, which involved determination of time of paralysis and time of death of the worms. The extract exhibited significant antihelmintic activity at highest concentration of 100 mg/ml. Piperazine citrate (10 mg/ml) was included as standard reference and distilled water as control. The extracts were found not only to paralyze (Vermifuge) but also to kill the earthworms (Vermicidal).

Anaphalis Lawii

Elemental analysis, anticariogenic, insecticidal and anthelmintic activity of Anaphalis lawii (Hook.f.) Gamble

The present study aimed at determining elemental composition, anticariogenic, insecticidal and anthelmintic efficacy of Anaphalis lawii (Hook.f) Gamble (Asteraceae). Elemental composition of powdered leaf material was estimated by ICP-OES technique after microwave digestion. Anticariogenic activity of methanol extract was tested against 13 clinical isolates of Streptococcus mutans by Agar well diffusion method. insecticidal activity of methanol extract in terms of larvicidal efficacy was tested against second instar larvae of Aedes aegypti. anthelmintic activity of methanol extract was determined using adult Indian earthworm Pheretima posthuma. The contents of potassium and iron were high among macro and microelements respectively. The leaf extract showed dose dependent inhibition of all S. mutans. The larvicidal effect of the extract was found to be dose dependent and the mortality of larvae of A. aegypti was recorded as 100% at 1.5mg/ml and higher concentrations of extract. The leaf extract resulted in paralysis and death of worms in a dose dependent manner.

The A. lawii leaf can be used as a source of various elements which play key role in the normal physiology of an individual. The plant can be used to treat dental caries and Worm infections and to control insect vectors. The bioactivities of extract observed in this study might be related to the presence of phytochemicals. Further studies concerning fractionation of leaf extract and bioactivities of fractions are to be carried out.

Annona Reticulata

anthelmintic activity of Annona reticulata leaves

Leaves of Annona reticulata L. (Annonaceae) were dried, powdered and extracted using ethanol and further fractionated using petroleum ether, chloroform, ethyl acetate, and ethanol. anthelmintic activity of these various fractions was evaluated on adult Indian earthworms Pherentima posthuma. Results showed that ethanol extract took less time to cause paralysis of the earthworms. In order to pinpoint the active constituent the ethanol fraction was further fractionated using column chromatography to yield fraction 1, 2, and 3 and again screened for activity.

Results showed that the fraction 2 is most potent followed by fraction 3 and then fraction 1. It can be concluded that anthelmintic activity of the leaves of A. reticulata is due to compound present in fraction 2 of ethanol fraction of total ethanol extract.

Argemone Mexicana

Argemone mexicana: Chemical and pharmacological aspects

The Papaveraceae, informally known as the poppy family, are an ethnopharmacologically important family of 44 genera and approximately 760 species of flowering plants. The present work offers a review addressing the detailed chemistry and pharmacology of Argemone mexicana L. regarded as one of the most significant plant species in traditional system of medicine. The plant is used in different parts of the world for the treatment of several ailments including tumors, warts, skin diseases, inflammations, rheumatism, jaundice, leprosy, microbial infections, and malaria. Interestingly, the plant is the source of a diverse kind of chemical constituents although alkaloids are mostly abundant.

Beyond pharmaceutical efficacies, certain plant parts also show toxic effects as well. Hence, an up-to-date information on the chemical and pharmacological knowledge on this plant may be helpful to guide researchers anticipating to undertake further investigations in these directions. The present review covers literature up to 2012 and enlists 111 references.

Arisaema Lobatum

anthelmintic activity of Arisaema franchetianum and Arisaema lobatum essential oils against Haemonchus contortus

Arisaema franchetianum and Arisaema lobatum are two perennial plants native to China. Arisaema franchetianum is universally used to promote the subsidence of induration and swelling, quicken blood and relieve pains, and kill intestinal parasites in humans and animals. Arisaema lobatum is used to treat malaria, intestinal parasites, and snake and insect bites in humans and animals. The aim of this study was to determine the composition of the essential oils from Arisaema franchetianum and Arisaema lobatum and evaluate the anthelmintic effect against Haemonchus contortus.

Aristolochia Indica

In Vitro Study on anthelmintic Activity of Aristolochia indica and A. tagala Roots

The present study has been undertaken to screen the anthelmintic potential of aqueous root extracts of Aristolochia indica Linn. and A. tagala Cham. against adult Indian earthworm Pheritima posthuma and round worms Ascaridia galli. Different concentrations of the extracts ranging from 2-8 mg/mL were screened. Piperazine citrate was used as reference standard. Extract of A. tagala was found to be more potent and effective at the dose level of 2 mg/mL compared to the extract of A. indica. Extracts showed dose dependant activity. The study reports that the plants A. indica and A. tagala roots possess potent anthelmintic properties.

Artocarpus Lakoocha

IN VITRO anthelmintic ACTIVITY OF SEED EXTRACT OF ARTOCARPUS LAKOOCHA ROXB

The ethanol extract of seeds of Artocarpus lakoocha Roxb. (ESAL) was investigated for anthelmintic activity using earthworms (Pheretima posthuma), tapeworms (Raillietina spiralis) and roundworms (Ascaridia galli). Various concentrations (10-50 mg/ml) of seed extract was tested in the bioassay. Piperazine citrate (10 mg/ml) was used as reference standard drug whereas DMF (Di-methyl formamide) as control. Determination of paralysis time and death time of the worms were recorded. Extract exhibited significant anthelmintic activity at highest concentration of 50 mg/ml. The result shows that seed extract possesses vermicidal activity and found to be effective as an anthelmintic. The anthelmintic activity of ethanol extract of the seeds of Artocarpus lakoocha has therefore been demonstrated for the first time.

Asparagus Racemosus

Phytochemical Screening and In Vitro Comparative Study ofanthelmintic Activity of Asparagus racemosus and Cucurbita maxima

This study involves phytochemical screening and comparision of theIn-Vitro anthelmintic Activity of Asparagus racemosus and Cucurbitamaxima using adult Indian earthworm model.Methods : phytochemical investigation was done and anthelminthic assay was evaluated for both ethanolicand aqueous extracts of 100 and 200 mg /ml of both Asparagus racemosus and Cucurbita maxima by comparing parameters of time taken for paralysis andtime taken for death.Key findings : anthelminthic assay revealed that extracts of both plants showed significant anthelminthic activity .Dose dependentactivity was observed in Ethanolic and Aqueous extracts of both plants but Ethanolic root extract of Asparagus racemosus shows activity comparable withthat of standard Albendazole ( 20 mg / ml ) and better activity in comparision with cucurbita maxima.Conclusions : The results revealed that anthelminticactivity of Asparagus racemosus Ethanolic root extract was closely related to the Albendazole.

Asuro (Justicia Adhatoda)

anthelmintic ACTIVITY OF ASURO (Justicia adhatoda) AGAINST GASTROintestinal nematodes OF GOATS

The anthelmintic activity of Justicia adhatoda leaves was evaluated against the gastrointestinal nematodes (GINs) of goats through fecal egg count reduction test in vivo & egg hatch inhibition test in vitro from July 2013 to October 2013. For in vivo experiment, goats were randomly divided into five treatment groups. Among five treatment groups, positive and negative control group received Albendazole (ABZ) and No Treatment (NT) respectively; remaining three groups received different doses of methanol extract of J. adhatoda as T1 : 100 mg/kg body weight, T2 : 150 mg/kg body weight and T3 : 200 mg/kg body weight. Fecal egg count reduction (FECR) was calculated on day 0, 7, 14 & 21. Data were analyzed by using SPSS software, Least significant Difference (LSD), least square procedure using Harvey (1990) and DMRT. The in vivo result indicated that T2 and T3 reduced EPG significantly (p<0.01) compared to NT on day 14 and day 21 post treatment. The highest reduction rate on FEC of treated group was 58.6% on 21 day post treatment at dose rate 200mg/kg body weight. For in vitro test different doses of methanol extract (50 mg/ml, 25 mg/ml, 12 mg/ml and 6 mg/ml) was used. In vitro test result indicated that egg hatch inhibition at 50 mg/ml was highest among the different treatment of methanol extract of J. adhatoda. Methanol extract showed dose dependent inhibition in in vitro egg hatch assay.

The findings suggested that J. adhatoda leaf could be a promising alternative to commercially available synthetic anthelmintics. However further investigations to identify the biologically active compound to establish the dose rate and to understand the pharmacokinetics and level of toxicity are required to establish this plant as herbal anthelmintics.

Averrhoea Carambola

antimicrobial activity of Averrhoa carambola L. leaf extract and its Phytochemical Analysis

Growing drug resistance of microorganisms and adverse result of antibiotic usage have led to the search for alternative medicines from nature. Many plants have been exploited to cure infectious diseases from time immemorial. The current investigation deals with the evaluation of the antimicrobial activity, preliminary phytochemical screening and Thin Layer Chromatography (TLC) analysis of Averrhoa carambola L. leaf extracts. The antimicrobial activity was done by agar well diffusion method. Preliminary phytochemical screening was done by standard method. Plant extracts were found active against all the bacteria. Aqueous extract of A. carambola leaves showed higher antibacterial activity as compared with methanol and petroleum ether extract at the concentration of 25 mg/ml. Highest antibacterial activity was exhibited by the aqueous extract against Salmonella typhi (29.23±0.02 mm). The highest antifungal potential was exhibited by the methanol extract against Candida krusei (21.09±0.08 mm). Plant extracts were observed to be active against all the fungal pathogens except Aspergillus niger.

Minimum inhibitory concentration (MIC) was determined using serial dilution method. The preliminary phytochemical analysis revealed the presence of alkaloids, tannins and polyphenolic compounds, flavonoids, phytosterol, proteins and amino acids, carbohydrates, glycosides etc. while saponins was absent in both the extract. The petroleum ether and methanolic extracts were subjected to TLC study and the Rf value of different spots was observed in various solvent systems. The outcomes of the present study indicate that A. carambola leaf is endowed with potential antimicrobial activity and hold promise for development of pharmaceuticals and antimicrobial agents in future.

Baccaurea Ramiflora

STUDY OF anthelmintic AND insecticidal ACTIVITY OF BACCAUREARAMIFLORAPLANT IN DIFFERENT EXTRACTS

Baccaurea ramiflora Lour., syn. Baccaurea sapida (Roxb.) Muell. Arg. known as Burmese grapes belongs to the family Euphorbiaceae and is native to Southeast Asia. The observance on Baccaurea ramiflora leads that this plant is utilized as an antichloristic and anodyne against rheumatoid arthritis, abscesses, cellulitis and treat injuries. This plant also has anti-diarrheal, analgesic, anti-inflammatory, neuro-pharmacological, antioxidant and cytotoxic activities. Therefore, the present study was conducted to evaluate anthelmintic and insecticidal activities of different extract of Baccaurea ramiflora. For anthelmintic activity, Pheretima posthuma was selected as test animal while 25, 50, 100 mg/ml concentrations of samples weretested in the bioassay, from which time of paralysis and time of death of worms were estimated.

Evaluation of insecticidal activity was performed against Sitophilus oryzae to calculate the mortality rate. Extracts of MEE, EE, ACE, CHE, PEE, and NHE were for the activity determination. In the anthelmintic study, extract exhibited its activity in a dose-dependent manner showing higher the concentration, faster the effect. Extract of EE, PEE, CHE and MEE in case of 100 mg/ml concentration exhibited its paralytic effect followed by death within a short period among which ACE extract gave the best result which only took approx. 22.33 min to show paralytic effect and 33 min for death occurrence. In the insecticidal activity, all extracts showed potent activity with 100% mortality of rice insects Sitophilus oryzae at 80 mg/ml concentration in 24 h, proving the activity also followed a dose-dependent pattern. 80% mortality rate observed in case of 80 mg/ml concentration of ACE extract in 12 h whereas MEE, CHE, and NHE extracts showed 60% and PEE showed 70% mortality rate in treated rice insects.

The present study shows that all the extracts of Baccaurea ramiflora are found to possess anthelmintic and insecticidal activities.

Baliospermum Montanum Muell

In Vitro anthelmintic Activity of Baliospermum montanum Muell. Arg roots

Alcohol and aqueous extracts from the roots of Baliospermum montanum Muell. Arg were investigated for their anthelmintic activity against Pheretima posthuma and Ascardia galli. Various concentrations (10-100 mg/ml) of each extract were tested in the bioassay, which involved determination of time of paralysis and time of death of the worms. Both the extracts exhibited significant anthelmintic activity at highest concentration of 100 mg/ml. Piperazine citrate (10 mg/ml) was included as standard reference and distilled water as control.

Biophytum Petersianum

In vitro potential anthelmintic activity of Biophytum petersianum on Haemonchus contortus

Haemonchus contortus is a major problem in small ruminants in Indonesia. The frequent use of the anthelmintic drugs has given rise to drug-resistant populations which increase the need for new anthelminthic compounds, particularly from endemic plants. This study evaluated the in vitro effects of Biophytum petersianum crude aqueous extract (BAE) as an anthelmintic compound against H. contortus adult Worm isolated from goats.

Bougainvillea Glabra

Evaluation of anthelmintic Activity of bougainvillea glabra Leaves

The present study was designed to explore the anthelmintic activity of different extracts of leaves of Bougainvillea glabra using petroleum ether, ethyl acetate methanol and water as solvents. Various concentrations (25 and 50mg/ml) of all the extracts were tested, which involved determination of time of paralysis and time of death of the worms. It was compared with Albendazole as standard reference and normal saline as control. The study indicated the potential usefulness of Manihot esculenta against earthworm infections.

Bridelia Ferruginae

Evaluation of anthelmintic activity of the stem bark extract and chemical constituents of Bridelia ferruginae (Benth) Euphorbiaceae

anthelmintic properties of the stem bark extract and compounds isolated from Bridelia ferruginae were investigated. In relation to the traditional use of B. ferruginae against gastro-intestinal infections, bioactivity-guided fractionations of the CHCl3- and CH2Cl2- soluble fractions of the 80% MeOH extract from the stem barks of B. ferruginae yielded two known triterpenoids: betuline (1), glucoside of betulinic acid (2) and other two known flavonoids: quercetin (3) and kaempferol (4). Structures of compounds 1 to 4 were elucidated by spectroscopic studies and comparison with related compounds in literature. The time of paralysis and death of the parasitic worms: Fasciola gigantical (liver fluke), Taenia solium (tape Worm) and Pheritima posthuma (earthworm, Annelid) were determined at 25, 50, 80 and 100 mg/ml. The stem barks extract of B. ferruginae and isolated compounds demonstrated concentration-dependent anthelmintic potencies against parasitic worms assayed. Structural-activity relationship is explained.

Caesalpinia Pulcherrima

INVESTIGATION OFIN VITROanthelmintic ACTIVITY OFCAESALPINIA PULCHERRIMALEAVES

The crude Pet. Ether, dichloromethane, ethyl acetate and ethanol extracts ofCaesalpinia pulcherrima (Caesalpiniaceae) leafwere investigated for in-vitro anthelmintic activity on the Indian adult earthworms Eisenia foetida. The various concentrations(20, 40, 60mg/ml) of extracts were tested in-vitro for anthelmintic potency by determination of time of paralysis and time ofdeath of Worm. The leaf extracts of Caesalpinia pulcherrima exhibited a dose dependant inhibition of spontaneous motility(Paralysis) of earthworms. Piperazine citrate (10mg/ml) was used as standard drug and distilled water containing 2% tween 80was as control. All the extracts were found to be exhibited dose dependent anthelmintic activity.The decreasing order ofactivity of extracts was ethyl acetate, ethanol, dichloromethane and petroleum ether extracts. Thus the present studydemonstrates that the leaf of Caesalpinia pulcherrima could be categorized under anthelmintic herbal drugs and could beused as a potent key ingredient of herbal formulation.

Cajanus Cajan

anthelmintic activity of leaves of Cajanus cajan Linn. on Indian earthworm

Modern synthetic medicines are very effective in curing diseases but also cause a number of side effects. parasites are of concern to the medical field for centuries and the helminthes considered causing considerable problems for human beings and animals. To investigate the anthelmintic activity of Cajanus cajan. Dried powder was taken and subjected to successive extraction with petroleum ether, ethyl acetate, ethanol and water in soxhlet apparatus. The anthelmintic activity was evaluated on adult Indian earthworm pheritima posthuma due to its anatomical and physiological resemblance with the intestinal roundWorm parasites of human beings. The earthworms were divided in nine groups, each group consisting of six earthworms of approximately equal size were released into 50 ml of the extract. Albendazole using as a standard drug, both alcoholic and aqueous extracts has shown significant anthelmintic activity compared to standard drug albendazole.

The data reveals that the aqueous extract shown anthelmintic activity for paralyzing as well as death of Indian earthworm pheritima posthuma at 5mg concentration is of long duration of time, whereas the ethanolic extract showed paralysis and death at similar concentration in short time duration. The leaves of Cajanus Cajan Linn. Ethanolic extract has given potent anthelmintic activity as compared to standard drug, thus it is evident that leaves of this plant of daily use is useful for anthelmintic activity and it is concluded that further research is possible for finding active compound responsible for this activity.

Camellia Sinensis

In vitro anthelmintic Activity of Ethanolic Extracts of Camellia sinensis L. and Albizia lebbeck L. against Haemonchus contortus

helminths are familiar as a major problem to livestock production. helminths cause multiple infections in animals of significant economic importance. Haemonchus contortus, (helminths Worm), is highly infectious parasite of small ruminants, and is a major cause of diseases and significant mortality in various cattle, sheep, deer, buﬀalo and goat, etc. Various synthetic anthelmintics have been used, on wide scale, to control the helminths infections.But the parasite worms have developed multiple resistances against the synthetic anthelmintics. Hence, various biological controls, vaccines and local medicinal plants are being explored to control the parasitic worms.

The aim of this study was to evaluate the anthelmintic potential of two local plants, Albizia lebbeck L. and Camellia sinensis L against H. contortus using Adult Motility Assay (AMA). Crude Ethanolic Extracts (CEE)of dried leaves of A. lebbeck L. and whole plant of C. sinensis L. were prepared by cold maceration method. The anthelmintic activity was analyzed by adult motility assay (AMA). Levamisole was used as positive control to compare the eﬃcacy of CEE of both plants. Adult worms were treated with diﬀerent concentrations i.e., 2, 4, 6 and 8 mg/ml of ethanolic extract and motility of the worms was examined after every two to eight hours. Both A. lebbeck and C. sinensis exhibited 88% and 95% mortality at 6 & 8 mg/ml after 8 hrs of treatment. In conclusion, the ethanolic extracts of A. lebbeck L. and C. sinensis L. showed in vitro anthelmintic activity against H. contortus at concentrations tested.

Canarium Schweinfurthii

In Vitro anthelmintic Activity of Mucuna pruriens (DC) and Canarium schweinfurthii (Engl) on Ascaris suum

The in vitro anthelmintic evaluation of the crude extracts and solvent partitions on Pheretima post-huma and Ascarissuum (eggs and L2 stage) respectively showed significant results at the same concentration (10, 20, 40 and 80 mg/ml). This study provides a clear evidence for usage of Mucuna pruriens and Canarium schweinfurthii as an anthelmintic.

The most potent ovicidal partition of C. schweinfurthii (Engl) leaves and bark and leaves of M. pruriens (DC) is hexane (100.00 ± 0.33), chloroform (98.20 ± 0.12) and chloroform (98.70 ± 0.88) partitioned crude respectively at 80 mg/ml while the most potent larvicidal partition is hexane (0.06%), chloroform (0.1%) and chloroform (0.2%). The active compounds are predominantly in the non-polar solvent which supports the te-gumental diffusing activity of the compounds.

Capparis Spinosa

potential anthelmintic effect of Capparis spinosa (Capparidaceae) as related to its polyphenolic content and antioxidant activity

Capparis spinosa is cultivated for several proprieties and the different parts of the plant (flower buds, fruits, leaf and seeds) have been employed in drugs, foods and cosmetics. This study aimed to explore the antioxidant potential effect and to assess the anthelmintic efficacy of an aqueous extract of Capparis spinosa. In vitro antioxidant activity of aqueous extracts from the fresh leaves and flower buds of C. spinosa was measured by determining free radical-scavenging activity against DPPH and ABTS radical cations. In vitro anthelmintic activities against eggs and adult worms of Haemonchus contortus from sheep were investigated in comparison to albendazole. DPPH and ABTS activities of both aqueous extracts increased in a dose dependent manner. The IC50 values of aqueous extracts from fresh leaves, flowers buds and ascorbic acid in the DPPH radical scavenging assay were 101.40; 70.40 and 57.56 μg/ml, respectively.

The IC50 values of aqueous extracts fresh leaves, flowers buds and ascorbic acid in the ABTS radical scavenging assay were 110; 87.89 and 58.17 μg/ml, respectively. Both plant extracts showed ovicidal activity at all tested concentrations. The aqueous extract from flower buds (IC50 = 2.76 mg/ml) showed higher inhibitory effects (P < 0.05) than aqueous extract from leaves (IC50 = 8.54 mg/ml) in the egg hatching assay. The aqueous extract from flower buds inhibited more worms than the aqueous extract from leaves at all tested concentrations. After 6 h of exposure, the highest tested concentrations of aqueous extracts from flower buds and leaves induced 100 and 41.66% inhibition of motility, respectively.

These results show for the first time that C. spinosa possesses in vitro anthelmintic properties which may be related to its high content of phenolic compounds such as flavonoids and tannins.

Carica Papaya

Evaluation of anthelmintic activity of ethanolic extracts of Carica papaya leaves using Paramphistomum cervi and Haemonchus contortus

The aim of this present study is to evaluate the anthelmintic activity of leaves extracts of Carica papaya using Paramphistomum cervi and Haemonchus contortus as the test worms. A range of concentrations (100, 50 and 25%) of ethanolic extracts of C. papaya were tested to assay the procedure. This is mainly applied for the determination of time of death (D) and time of paralysis (P) of the tested worms. After the analysis, it was shown that for the H. contortus at 100% concentration, the paralysis occurred within the shortest time (P=24.5 min) and death came at the lowest possible time (D=56 min). The time of death and paralysis increased at 50% (D=64 min and P=28 min) and 25% concentration (D=74 min and P=34 min), respectively compared to the Piperazine citrate (P= 24 min and D= 54) at concentration of 10 mg/ml. Here, distilled water is as a control solution.

The results of this study revealed that the ethanolic extracts of the leaves of the C. papaya expressed a demonstrated paralysis significantly, and also responsible for the death of P. cervi and H. contortus especially at the higher concentration (100%) compared to the standard reference of Piperazine citrate. Therefore, from the results it is declared that the ethanolic extracts of the leaves of C. papaya showed a great anthelmintic activity against P. cervi and H. contortus worms. Hence, the present research work signifies that the leaf of C. papaya has a major anthelmintic activity and also can be used as a potent drug for its low cost and availability.

Carum Copticum

anthelmintic activity of Carum copticum seeds against gastro-intestinal nematodes of sheep. J Animal Plant Sci 16(1-2):34-37

This paper describes in-vivo anthelmintic activity of Carum copticum in comparison with levamisole. For in-vivo studies, the seeds of Carum copticum was administered as crude poweder (CP), Crude equeous extract (CAE) and crude methanol extract (CME) at graded doses (1,2 and 3 g kg -1 body weight (b.w.) to sheep naturally infected with mixed species of gastrointestinal nematodes. Maximum reduction (79.1%) in eggs per gram (EPG) of faeces was recorded on day 14 post treatment in sheep treated with Carum copticum CP at 3g kg -1 b.w.

It was found that although, carum copticum seeds possesses anthelmintic activity against nematodes, it is not comparable with levamisole (99.2% reduction in EPG) at any of the doses tried in this study. However, increase in EPG reduction was noted with an increase in the dose of Carum copticum administered as CP, CAE and CME. The graded dose response suggested further studies on a larger number of animals on higher doses than those used in the current study.

Cassia Fistula

Assessment of anthelmintic Activity of Cassia fistula L

There is increasing demand of herbal medicine worldwide, a great majority of medicinal plant were assessing for their efficacy. World health organization estimated that two billion of people harbor parasitic Worm infection. In view of this, attempts have been mad to study anthelmintic activity of Cassia fistula L fruit pulp and seeds. Both extracts were found not only paralyzed also killed the Pheritoma posthuma. The concentration of 100 mg/ml of extracts caused more significant paralysis as well as death of worms as compared to reference drug Piperazine citrate at dose of 10 mg/ml

Cassia Siamea Lamk

Exploration of anthelmintic activity of Cassia spp. extracts on gastrointestinal nematodes of sheep

This study aimed to explore the phytochemical constituents and anthelmintic activities of four Cassia spp. leaves against Haemonchus contortus. Materials and methods: The extracts were prepared from four species of Cassia spp. (C. siamea, C. fistula, C. surattensis, and C. spectabilis). Phytochemical screening of the extract was done based on the Harborne method. Evaluation of the anthelmintic activities against H. contortus was done in vitro using infective larvae (L3) migration inhibition assay (LMIA). Measurement of larvae migrating was conducted through a nylon filter with a pore size of 20 μm. The doses of Cassia spp. extract implemented were 25, 50, 100, and 200 mg/ml. Results: tannins, alkaloids, phenol hydroquinone, flavonoids, steroids, triterpenoids, and saponins were present in all the extracts, whereas alkaloids were absent in C. fistula.

size	100g, 200g, 800g
concentration	200:1, 20:1

14 reviews for STOMACH RESET COMBO (Fix Virtually All Gastrointestinal Problems) Featuring: PURGE/ PARASLAYER/ HELICO

Rated 5 out of 5

Joyce Modie (verified owner) – May 16, 2021

I have been Gavin’s silent Facebook follower for sometime. I was not really following his blends reviews much much until recently when our family health started declining. Over 2 months ago my husband started having really bad smell from his mouth. He couldn’t smell it first but those around him could. Eventually it got worse and he had to put on a mask all the time. He tried brushing and cleansing often. Taking mint, flossing and mouth washes were his close friends but still no improvement. This took his confidence and affected his everyday life. My good morning kiss stopped. When purge was released I spoke to Gavin about my husband’s condition and he lovingly advised us to get Stomach Reset Combo. We ordered same night and 6 days later we received our beautiful packaged life changing combo. Mind you we are all the way in Southern Africa, Botswana and to receive within 6 days as Gavin promised was a miracle. Less than 2 weeks ago my husband took the combo on a day he was not working. The purge was intense for him. He was in so much pain throughout. He was purging one end for hours then later he started vomiting. Mind you he is one man who never tries anything to cleanse his system. I was shocked he jumped in and paid for the combo immediately. The stomach cramps would intensify and get better after each vomit. A lot of mucus was coming out through his mouth. He stayed up all night still at it until early morning when he got a chance to rest. Pains had vanished completely by then. Smell was gone immediately, just like that. We were shocked and decided to keep checking daily for a couple more days and the smell is completely gone with just one cleanse. Just one, nothing more. I now get my morning kiss without any “morning breath” challenge. We are forever grateful to Gavin and the team. Thank you for saving us the shame and worry. We’re new to blends and still trying many more. Currently on Vital Force and we are looking forward to the results because we are already feeling it. We recommend Stomach Reset Combo for any gastrointestinal issue for healing and normal life. Once again thank you Gavin for saving lives and loving people selflessly.
Rated 5 out of 5

lewis (verified owner) – May 19, 2021

this combo set completely fixed my IBS. without even having any purge I started taking helico and paraslayer in kefir morning and night within a week all of my IBS symptoms had disappeared. sorry to be graphic but I hadn’t had a solid stool in over a year and doctors would just fod me off with IBS medication. these herbs along side the kefir have really sorted all of my symptoms and within a week!!

I then felt I was ready to purge… I took 1/4 teaspoon in grapefruit juice and quickly found out I wasn’t ready. that stuff is so powerful I was on the toilet for over and hour.

I have purchased other combo sets before and can hanoestly say they are life changing. trinity, nebula and thermo completely eradicated my anxiety last year (alongside fasting and excercise). I am I the best shape I have been in my life!
Rated 5 out of 5

Ndiri – July 17, 2021

Omg , big shoutout to the amazing Gavin who took his time out answering questions ,hes a kind man.i lost 15 pounds on purge less than 3 days.I love that i embrace this journey, and this purge taught me how to eat right,no more midnight snacks ,no more fatigue in the middle of day.

This the Benefit of Purge for me
help to boost my immune system,
– Keeps me focused
– Improves my mood
– Gives me better overall energy
– supports me weight loss etc
Purge is my life.
Rated 5 out of 5

mkendell (verified owner) – July 20, 2021

I have using Interstellar Blends for two years now. I have almost every blend, plus the Pine Pollen and Matcha, and my husband and I take (we rotate them) them daily. We use them as preventative medicine, We use them AS medicine. We use them for cellular health, anti-aging, energy and vitality. We have pretty much dived into the studies and literature on these amazing blends, and we are so grateful to Gavin for providing a healing path for literally any ailment or condition. My husband is a doctor, and he is all-in on the science and results we have experienced. I’m 50. I don’t look 50. I have energy, I’m never sick, and it’s due to the blends, and some time-restricted eating. I also try to stay on a pretty healthy, low-sugar, active lifestyle eating, but trust me, that doesn’t always happen. My vitality is not due to food and exercise alone. We have so many blend favorites but if I have to call out a few, Trinity, Nebula, Peel, Spice and Shilajit are in constant rotation. The newest blends are pretty much blowing my mind. The Stomach Reset Combo… wow.. Paraslayer and Helico have completely rid me of stomach ailments, and along with Purge (!!!!! this stuff is NEXT LEVEL) without getting too TMI, let’s just say that Purge does what the name states. The detoxing purge is real. Treat the Purge with respect and follow the dosing guidelines! We are forever customers and have started our kids on the some of the blends, as well. Do yourself and your health a favor and get yourself a sample pack. Or whatever you are able to start out with. Do some research, (Interstellar is always happy to answer questions and guide you to best blend choice), and get these blends.
Rated 5 out of 5

Katharina FInkmann (verified owner) – July 20, 2021

Dear Gavin,
First Thank you so much. I have been taking the blends for a few years in the hopes of healing my Eczema. It was relieved, not completely healed. I have been on the Paraslayer and Helico for the past couple of weeks. The Eczema is completely healed. Gone. Also I am highly allergic to Wasp Stings (and many other things) A couple of days ago I arrived home, grabbed the storm door and got stung by a wasp on my pointer finger. Besides it hurting, I thought for sure I would have to go to the Hospital. I went in, put alcohol on it and a band aide and waited. No sickness, no throwing up, no swelling. I give credit to the blends. Trying Purge on my next week off in August. Thank you so much.xoxo
Rated 5 out of 5

Tracy McCulloch – August 19, 2021

Over the past few years, I made a decision to heal myself from the inside. I basically felt I was just existing. Everyone else around me saw the sports coach, holistic therapist and all I saw was the broken woman from childhood abuse. I set goals and have always been a high achiever, but it always took a dip due to emotional stress, anxiety and eventually weight gain. So I was on a rollercoaster. I had been following Gavin on Facebook for a few years and finally plucked up the courage to find out more about Interstellar Blends. Firstly as always, my first goal was to lose weight quickly as it was prohibiting me from doing all the things I love. My self-esteem was low and I was perimenopausal so after reading the testimonials and being directed to the support group, I was sold. So many amazing results, advice, guidance and support. It was a no-brainer. and PURGE was ordered. I have tried many things in my time to lose weight quickly and always thought dry fasting was the only answer, which is amazing but very difficult to adhere to regularly. Purge had me dropping over 2kg the first day and not only that, it highlighted major stomach issues. To enable continuing with purge without feeling like vomiting, I was advised if I still felt like this after a week to use the stomach reset protocol i.e., Helico and Paraslayer (to rid me of the parasites that were in my gut, which most people have and don’t realise). So here I am 2 weeks down the line taking PURGE with no adverse side effects and happy as can be seeing the weight fall off (even whilst having a light meal yesterday I lost 1.5kg). Nothing compares to ‘PURGE’.

With my orders, Gavin generously gives samples for free and my first one was Supernova. This blend gives you energy (all day) without the feeling of irritation or worry that your heart is popping out of your chest. I love this blend and will never be without it. I am hooked on the blends because they are ‘life-changing. This being the case I ordered the July Special with 19 samples. Life was becoming so much more fun. In particular, one blend that stood out for me was ‘Trinity’., another blend I will not do without, ever. It gave me back my life with more confidence, completely eradicated my anxiety and just gave me that happy, glowing feeling every single day. Furthermore, the samples allowed me to experiment with my families ailments. Firstly, my daughter’s eczema which after only 2 days is less noticeable, with less itching and my partner’s legs and hands aches and pains from heart surgery also eased in such a short space of time with ‘PEEL and SPICE’. I am so grateful for the impact these blends have had on our well-being as a family.

In conclusion, these products enhance every aspect of your life and provide what we are all looking for in life, Happy Days. Thank you, Gavin.

Tracy McCulloch
Rated 5 out of 5

Jennifer Parra – August 27, 2021

This amazing combo (thank you Gavin!) has giving me my life back! I’ve been suffering from a very stubborn IBS flare up for probably over a year and nothing was helping. Everything I ate hurt me which was frustrating and exhausting to say the least. I always had to plan my meals very carefully especially when they revolved around a social event which was also very annoying and not always easy. Needless to say, I was miserable! Then, my sister told about this combo and how it was helping a lot of people with similar issues and decided to give it a shot! I’m SOOO glad I did! I’m beyond grateful for these blends, Gavin and my sister for suggesting that I try them! I decided to do two rounds with this combo (minus purge both times) and now I just keep feeling better and better and back to normal as I can now eat and enjoy food again without having to constantly worry if I’ll have to spend all night in the bathroom (sorry TMI) or spend days at a time in pain.

So in conclusion, if you are like me and are suffering from stomach issues please don’t hesitate to try these blends and reset your stomach ASAP!! You will NOT be disappointed and, like me, you can start to enjoy life again!!

Thanks again Gavin!

~ Jennifer Parra
Rated 5 out of 5

India Houston – December 29, 2021

The Stomach Reset combo is unlike any other! Purge specifically has been a lifechanger for me. My mother claims my intestinal issues may have derived from being premature and the medicines given at birth…I say it’s from the SAD diet given growing up (McDonald’s and other crap); nevertheless, I suffered chronic constipation all my life. Never able to “go” without some type of laxative. Had barium treatments but no issue was ever seen. (Of course not!) Sluggish insides…and I felt sluggish.

Now when Gavin mentioned the release of Purge earlier this year, I knew for a FACT that this product was designed for me and opted for the Stomach Reset combo because I knew I needed an entire gastric reset! Paraslayer and Helico were much needed added bonuses. Especially since without a doubt I knew that I was infested with Parasites. Let me say that my first time trying PURGE is an experience. Do not underestimate it! Follow Gavin’s instructions. Keep a fresh, wet, warm rag (that you are willing to part with) or some Dude Wipes because your butt will need it!!! Stay by the toilet & do not have any plans especially if you are doing a Challenge.

Since taking all three, specifically PURGE, the brain fog that has plagued me for so long is lifted. My stomach pudge has minimized. The focus and clarity is amazing. Being able to go #2 and feeling clean internally, it’s indescribable. I cannot see myself not having these products. Name a better trio?! I can’t!
Rated 5 out of 5

Valerie Cade (verified owner) – January 9, 2022

Imagine a lady, fairly healthy, age 82 who all of a sudden had diarrhea and was losing weight like crazy due to eating a bad steak; for six weeks ~ just shy of going to the hospital when she then tried Gavin’s Stomach Re-Set Combo. After one week of taking everything as directed, even upping purge near the end, she turned the corner and was able to rid herself of the pain and diarrhea. To quote her: “I don’t think I’d have made it to my 83rd without this Stomach Re-Set!” We are so thankful that we could quickly get this to her and in fact, I’ve made the decision to have this on hand should anyone else be in the same boat (or is that toilet bowl :)! Thank you Gavin!
Rated 5 out of 5

Amber Wippel (verified owner) – February 1, 2022

This one is a long story that I’ll try to keep short. About two years ago my husband starting complaining of pains in his stomach. Around the same time I thought I had a UTI. My husband went to the doctor and they told him his back was hurt and he needed PT. I was told that I needed antibiotics, which obviously never cleared up my issue. Our health kept declining and I struggled to keep myself above water. Trying to keep myself on a schedule, along with a hard headed man wasn’t there easiest of tasks. Looking back, we made mistakes.
Fast forward to about a month ago. I had done a lot of research to nail down our issues and began to think that we had the same issue, but it manifested differently. I knew it was either yeast or parasites. 🥴 I had helico from a previous order and stated my case to my husband. He was tired, so he gave in quickly and got on board. Within two days I noticed white specs in my feces. (I know. TMI) I was low key excited to see that because it meant I was on to something. 🤷🏼‍♀️ Two years of pain, this girl was exhausted. I immediately ordered the entire bundle because I only had two weeks for each of us left in the first batch.
We are on week 3 now. Eating within a 3-4 hour window, helico, paraslayer and purging every few days to once a week.
I swear to everyone, our pain is completely gone. If you’ve been diagnosed with IC, fatty liver, or whatever else they think sounds fun to say, do your own research. Clean your gut. I will literally do 2-3 cleanses a year, along with take this daily. This will NEVER EVER happen again. Cheers everyone and good luck on your healing journeys.
Rated 5 out of 5

Geraldine (verified owner) – April 24, 2022

I’d been suffering with severe pain in my left side, lower ribs, for about two years sporadically.
I had also developed gastritis and then inflammation along my hypochondrium area.

I was in severe pain and I lost 21lbs due to my stomach hurting if I ate too much. My appetite diminished dramatically and I began to feel weak and I didn’t want to move very much.
I have to admit that I was in a state of fear at this time.. I was definitely thinking the worst case scenario and of course that doesn’t help.

Although I am a life long ‘avoider’ of Doctors, I opted to go for a diagnosis.
The Doctor decided it was probably a ‘peptic ulcer’ which had also traveled down into the duodenum. She took bloods and also requested a hospital appointment to check stomach, spleen, pancreas and liver. This was because I have no other symptoms like heartburn or coughing.

Anyway, I decided on my own treatment. I contacted Gavin who suggested the stomach combo along with the ‘liver sample.’ This was about two months ago.

I was so relieved to receive the package and start on the treatment.
I started with Hyliobactor, paraslayer and the liver sample. I admit, I was apprehensive about taking Purge after reading the comments!! Lol!

Within four days the pain in my stomach subsided significantly. Over the following two weeks or so, I started to feel more grounded in my body and take an interest in life again. My energy improved a hundredfold as did my sociability.
Now I have no pain!!
What I noticed in this healing! If it was a peptic ulcer(s) they have gone completely. There is no pain or tenderness in my stomach or duodenum, which I could feel in the mid abdomen. (Hyliobactor)
I started to notice lots of little white specks in my stool – probably parasitic eggs! Still taking paraslayer until this is gone completely.
The liver blend. Amazing! I developed a fungal nail last year and most of my finger nail peeled off. Liver blend has almost cured this! Liver governs nails, tendons, bone, teeth. The nail is almost fully grown back.
Purge.. Well I decided to try it. It does it’s job! So I’m taking that every couple of night’s now, just one little spoonful. It keeps everything moving..

As regards the hospital, I received a date for late May! Good job I don’t rely on those services to keep me healthy!
Massive thanks for the unending support of Gavin and his team.
Rated 5 out of 5

Tina (verified owner) – August 23, 2022

Wow where do I start. I started taking interstellar blends at the end of 2021 and nothing in words can describe how they have levelled up my mind, body, spirit and changed my life more in more ways than I could ever imagine. Life is just amazing & I am thankful for Gavin everyday. I am completely off all medication & I just love life so much. Before blends, I was pretty much a walking zombie; constantly getting sick , health issues, on and off medication, I yearned to feel ‘normal’ and I can finally say I am at that point right now and more. Let me give you a summary of some of my favourite blends:

TRINITY : Before meeting Trinity I was a complete daily mess of anxiety & depression. I would have several panic / anxiety attacks a day & I still remember waking up with my heart feeling like it was off the charts and completely dreading the day. I didn’t want to do anything, I had such a negative outlook on life & was in constant victim mode. I’ve done a complete 180 on Trinity, she’s made the biggest impact on me & I could never live without it again. I don’t have anxiety anymore & I wake up so excited to welcome what the day holds for me. I am so full of gratitude for being alive, I love life so much! Everyone around me constantly describes me as a ray of sunshine. Trinity has helped me fix my relationship with myself, and of course that trickles into my relationships and daily life.

PLUSH : I am so thankful for Plush as the last medication for me to get off was the contraceptive pill. Like many girls , I was put on it when I was a teenager for acne, supposedly caused by ‘hormone issues’ and had been struggling to get off it for the better part of 10 years. Whenever I tried to get off it, the acne would come back full force , mood swings, my periods super irregular. In May this year, I started on Plush and that was the last time I was on the pill. My acne has NOT come back at all, my periods are regular now, I don’t have any PMS symptoms and I finally feel like my body is a part of me. In a sense I finally feel like myself , I love my body and self now and that’s the best I can describe it. ALSO, I have always looked younger all my life , I am currently 27 and would get mistaken for 20 – 23 all the time. But now new people I meet are shocked I am even over the age of 17- 18! I believe this is because Plush has cleared up old acne scars & sun damage/ pigmentation has also lightened up over the last few months. My face also seems more lifted then it did before Plush as if my skin is producing a lot of collagen again – before Plush I noticed my jowls had began to start drooping, in which I assumed the normal ageing process was starting , but now that’s gone too!

SPICE & PEEL : All my life I struggled with allergies, I felt like my body was allergic to everything that was part of the earth. I was constantly on a cycle of having hay fever, eczema and hives & one day I realised I had none of these… for months which had never happened before. I don’t remember the last time I touched an anti-histamine pill nor be covering myself in steroid cream. I don’t wake up sneezing or with a blocked nose, I don’t come back with rashes anymore when I go hiking or bush walking. Any cuts I get or bruises heals FAST within days. It’s also eliminated all inflammation I would experience from allergies as well.

REWIRE : This has to be my favourite blend on par with Trinity for eliminating distractions. Although never being professionally diagnosed due to my refusal to be on medication, I know I have what they call “ADHD”. Rewire, just shuts down the constant chatter in my mind and makes me get things done! I don’t procrastinate nor zone out anymore, and tasks don’t feel like heavy chores. It has stopped me from thinking about food all the time, kept me on strict 22/2 sometimes even longer, eliminated my shopping and nicotine addiction & I have even become the best performer in my team at work. People are sometimes baffled at how I am so efficient, whilst producing top quality work & how great my attention to detail is sometimes. Anything from time management to money management is great now. I understand new concepts so so easy now – currently undertaking a couple courses & it baffles me how I feel like I’m on the ‘limitless’ pill at times. Things just click!

STOMACH RESET COMBO : And lastly, a homage to Helico , Paraslayer & Purge. To sum it up before introducing this trio, for as long as I could remember, I was struggling with constant food intolerances, insane bloating , gut and digestion issues. Sometimes I would eat & I would automatically throw up, or be in digestion pain for the whole day / night. This trio cured it all. It did take 2 – 3 months or so to clear everything up as my issues were very much in the deep end , but just like my other past health issues, I can’t believe how i am ‘normal’ now. Food makes me so happy now & I am just so grateful I have a beautifully working digestive system now.
Rated 5 out of 5

Kristen King – October 29, 2022

Let’s just start by saying if you’re not ready to be your best version in this life stay away. I’ve been on blends for over a year now and I am currently taking 21 different blends but I do have some favorites. They include trinity, nebula, rewire, paraslayer (forever), helico, victorious and now the spaceborn. My whole family takes these blends including my 3 dogs. The clarity, sharpness, balance, and overall happiness we feel on these blends is out of this world.
Let’s talk about the stomach reset which was the first combo I bought. I had no idea at the time but hellooooo parasites, I didn’t realize I had so many! Wow! It took me down lots of parasite rabbit holes. I’m convinced now they are the root of all disease. I’ve also read ingredients on other companies that sell parasite meds (cellcore) and Interstellars matched plus many more. It’s a win-win!!
I tell anyone who wants to listen about the blends. It’s become our families Healthcare policy as I’m not interested in our shitty so called Health system in the US, it lies, steals, and kills! My morning coffee is now my favorite time of the day, it’s like I’m putting on my armor for the day!! Thank you Gavin, your blends are truly amazing and life changing. You have a customer for life! ❤️
Rated 5 out of 5

Antunes (verified owner) – May 23, 2023

So, it took me quite a while to get around to writing this review because I really wanted to give these herbs a proper test before sharing my thoughts here. Let me tell you, I’ve been dealing with this annoying cough for years now. I’ve seen countless doctors who all told me it was my stomach acid causing the coughing after meals and at bedtime. Their solution? Pop some pills to “manage” it. But honestly, I wasn’t too thrilled about going down that route.

So, I decided to give this combo a shot instead. And let me tell you, within just two weeks, I started noticing some serious improvements! My coughing reduced by a solid 50%. I kept following Gavin’s advice and took it with some Kefir. Fast forward a couple of months, and guess what? No coughing at all! I was seriously blown away.

Then I got a bit careless as I was running out of the supply, so I stopped taking the herbs. And you know what happened? Yep, my cough gradually crept back in. That’s when I realized that these herbs were really doing wonders for my GI issues and reflux.

Oh, and let me tell you about the “purge”. I read in the reviews that it’s better to start slow, so I waited two weeks after taking Helico and Paraslayer before giving Purge a shot. I took 1/4 of a teaspoon as I felt that lower amounts wasnt working. And boy, did it work! After a few trips to the toilet, I saw some seriously nasty parasites coming out. The other times I tried the purge, nothing quite as horrifying came out, so I guess it had cleaned myself out pretty well the first time around!

Honestly, if you’re struggling with stomach problems, I totally recommend giving this combo a go. It’s been a game-changer for me in terms of tackling my cough and getting my GI health back on track.

Thanks Gavin for everything!